WO2023185839A1 - Système de détection microfluidique et procédé de commande associé, et réfrigérateur - Google Patents

Système de détection microfluidique et procédé de commande associé, et réfrigérateur Download PDF

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Publication number
WO2023185839A1
WO2023185839A1 PCT/CN2023/084383 CN2023084383W WO2023185839A1 WO 2023185839 A1 WO2023185839 A1 WO 2023185839A1 CN 2023084383 W CN2023084383 W CN 2023084383W WO 2023185839 A1 WO2023185839 A1 WO 2023185839A1
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WIPO (PCT)
Prior art keywords
temperature
microfluidic
preset
microfluidic biochip
biochip
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PCT/CN2023/084383
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English (en)
Chinese (zh)
Inventor
赵斌堂
费斌
朱小兵
Original Assignee
青岛海尔电冰箱有限公司
海尔智家股份有限公司
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Publication of WO2023185839A1 publication Critical patent/WO2023185839A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D23/00—General constructional features
    • F25D23/02—Doors; Covers
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D23/00—General constructional features
    • F25D23/06—Walls
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D29/00—Arrangement or mounting of control or safety devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D23/00—Control of temperature
    • G05D23/19—Control of temperature characterised by the use of electric means
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D23/00—Control of temperature
    • G05D23/19—Control of temperature characterised by the use of electric means
    • G05D23/30—Automatic controllers with an auxiliary heating device affecting the sensing element, e.g. for anticipating change of temperature
    • G05D23/32—Automatic controllers with an auxiliary heating device affecting the sensing element, e.g. for anticipating change of temperature with provision for adjustment of the effect of the auxiliary heating device, e.g. a function of time
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K7/00—Constructional details common to different types of electric apparatus
    • H05K7/20—Modifications to facilitate cooling, ventilating, or heating
    • H05K7/2089—Modifications to facilitate cooling, ventilating, or heating for power electronics, e.g. for inverters for controlling motor
    • H05K7/20945—Thermal management, e.g. inverter temperature control

Definitions

  • the invention relates to refrigeration and freezing technology, in particular to a microfluidic detection system and its control method, and a refrigerator.
  • the fruits, vegetables and agricultural and sideline products we buy daily may contain excessive pesticide residues. If the excessive pesticide residues in these foods are not discovered in time, it will cause great harm to the human body after ingestion.
  • the breastfeeding currently advocated is the best feeding for the baby only if the breast milk has normal nutritional value. However, if the wet nurse is sick, takes medicine, has surgery or other circumstances, the nutrients in the milk secreted by the wet nurse may be compromised. The element content is reduced and even viruses are produced, thus affecting the growth, development and health of the baby.
  • the detection reagents especially enzymes, only have good activity or performance at a specific temperature and can fully react with the sample liquid. If the temperature is too high or too low, it will affect the activity or performance of the detection reagent, thereby affecting the accuracy of the detection results.
  • An object of the first aspect of the present invention is to overcome at least one defect of the prior art and provide a control method for a microfluidic detection system that can avoid the temperature of a microfluidic biochip from being too high or too low.
  • a further object of the first aspect of the present invention is to improve the detection efficiency and the stability of temperature control of the microfluidic biochip.
  • the second object of the present invention is to provide a microfluidic detection system that can prevent the temperature of the microfluidic biochip from being too high or too low.
  • the third aspect of the present invention aims to provide a refrigerator with the above-mentioned microfluidic detection system.
  • the present invention provides a control method for a microfluidic detection system, which is used to conduct qualitative and/or quantitative detection of preset detection parameters of a sample, and the microfluidic detection system
  • the fluidic detection system includes a microfluidic biochip for allowing sample liquid and detection reagents to react within it, and the control method includes:
  • the first indication signal When the first indication signal is obtained, a prompt for indicating that the temperature of the microfluidic biochip is too high is issued. Wake up information, the first indication signal is used to indicate that the temperature of the microfluidic biochip is too high;
  • the microfluidic biochip When a second indication signal is obtained, the microfluidic biochip is heated, and the second indication signal is used to indicate that the temperature of the microfluidic biochip is too low.
  • the first indication signal and the second indication signal are generated in the following manner:
  • the first indication signal is generated when the temperature of the microfluidic biochip is higher than the maximum endpoint value of the first preset temperature range
  • the second indication signal is generated when the temperature of the microfluidic biochip is lower than the minimum endpoint value of the first preset temperature range.
  • the microfluidic detection system further includes a heating device for heating the microfluidic biochip;
  • the step of heating the microfluidic biochip includes:
  • the operation of the heating device is controlled according to the target duty cycle.
  • the target duty cycle of the heating device is the first preset duty cycle
  • the target duty cycle of the heating device is the second preset duty cycle
  • the target duty cycle of the heating device is the third preset duty cycle
  • the first preset temperature value is less than the second preset temperature value
  • the second preset temperature value is less than the minimum endpoint value of the first preset temperature range
  • the first preset duty cycle The second preset duty cycle and the third preset duty cycle decrease in sequence.
  • control method further includes:
  • the step of continuing to heat the microfluidic biochip includes:
  • the step of restarting the heating device to reheat the microfluidic biochip includes:
  • the fourth preset duty cycle is less than or equal to the third preset duty cycle.
  • the maximum endpoint value of the first preset temperature range is the sum of the preset temperature threshold and the first temperature difference value
  • the minimum endpoint value of the first preset temperature range is the difference between the preset temperature threshold and the first temperature difference value
  • the maximum endpoint value of the second preset temperature range is the sum of the preset temperature threshold and the second temperature difference value
  • the minimum endpoint value of the second preset temperature range is the difference between the preset temperature threshold and the second temperature difference value
  • the first temperature difference value is greater than the second temperature difference value.
  • control method before obtaining the first indication signal or the second indication signal, the control method further includes:
  • the present invention also provides a microfluidic detection system for qualitative and/or quantitative detection of preset detection parameters of samples, and the microfluidic detection system includes:
  • Microfluidic biochips are used for sample fluids and detection reagents to react within them;
  • a heating device for heating the microfluidic biochip
  • the control device includes a processor and a memory.
  • a machine executable program is stored in the memory, and when the machine executable program is executed by the processor, it is used to implement the control method according to any of the above solutions.
  • the present invention also provides a refrigerator, including:
  • a box defining a storage compartment for storing items
  • a door body connected to the box body to open and/or close the storage compartment;
  • microfluidic detection system according to any of the above embodiments is provided on the box or the door.
  • the control method of the microfluidic detection system of the present invention not only heats the microfluidic biochip when the second indication signal indicating that the temperature of the microfluidic biochip is too low is obtained, but also obtains the second indication signal indicating that the temperature of the microfluidic biochip is too low.
  • the first indication signal is sent out in time to facilitate the user to take action.
  • Using corresponding measures to cool down the microfluidic biochip not only avoids the adverse effects of the microfluidic biochip's temperature being too low on the test results, but also avoids the adverse effects of the microfluidic biochip's temperature being too high on the test results. , ensuring that the microfluidic detection system can obtain more accurate detection results in various usage environments.
  • the control method of the present invention also selects different target duty cycles of the heating device according to the temperature of the microfluidic biochip.
  • the temperature of the microfluidic biochip is When the temperature is too low, a larger target duty cycle can be used to increase the heating speed, thereby shortening the time consumed by the entire detection and improving detection efficiency; on the other hand, when the temperature of the microfluidic biochip is slightly lower , a smaller target duty cycle can be used to avoid excessive increase in the temperature of the microfluidic biochip caused by excessive heating speed, thereby avoiding large fluctuations in the temperature of the microfluidic biochip and improving the efficiency of the microfluidic biochip. Stability of biochip temperature control.
  • Figure 1 is a schematic flow chart of a control method of a microfluidic detection system according to one embodiment of the present invention
  • Figure 2 is a schematic flow chart of a control method of a microfluidic detection system according to another embodiment of the present invention.
  • Figure 3 is a schematic flow chart of a control method of a microfluidic detection system according to another embodiment of the present invention.
  • Figure 4 is a schematic flow chart of a control method of a microfluidic detection system according to yet another embodiment of the present invention.
  • Figure 5 is a schematic flow chart of a control method of a microfluidic detection system according to yet another embodiment of the present invention.
  • Figure 6 is a schematic structural block diagram of a microfluidic detection system according to one embodiment of the present invention.
  • Figure 7 is a schematic structural diagram of a microfluidic detection system according to one embodiment of the present invention.
  • Figure 8 is a schematic structural diagram of a refrigerator according to an embodiment of the present invention.
  • the present invention first provides a control method for a microfluidic detection system.
  • the microfluidic detection system of the present invention is used to conduct qualitative and/or quantitative detection of preset detection parameters of samples.
  • the preset detection parameters can be, for example, Pesticide residue parameters are used to indicate whether the pesticide residue amount exceeds the standard and/or the specific value of the pesticide residue amount; nutritional parameters are used to indicate whether the nutrient element reaches the standard and/or the specific content of the nutrient element; used to indicate specific harmful substances (such as specific virus) exceeds the standard and/or specific substance parameters of specific content, etc.
  • microfluidic detection system may include a microfluidic biochip for reacting sample liquid and detection reagents therein.
  • the microfluidic biochip usually only pays attention to the need to heat the microfluidic biochip when the temperature is too low, ignoring that in some special application environments, the microfluidic biochip may also have a temperature that is too high. question. Moreover, the temperature of the microfluidic biochip is too high or too low relative to the optimal reaction temperature of the detection reagent used. For example, if the optimal reaction temperature of the detection reagent is 20°C, any time the temperature of the microfluidic biochip exceeds 25°C is considered to be too high. However, in summer, microfluidic biochips placed in a room temperature environment will The temperature of the chip can easily reach 25°C. Therefore, whether the temperature of the microfluidic biochip is too high is also a matter of concern.
  • Figure 1 is a schematic flow chart of a control method for a microfluidic detection system according to an embodiment of the present invention.
  • the control method of the present invention includes:
  • Step S10 determine whether the first indication signal is obtained; the first indication signal is used to indicate that the temperature of the microfluidic biochip is too high; if yes, go to step S20; if not, go to step S30;
  • Step S20 sending a reminder message indicating that the temperature of the microfluidic biochip is too high
  • Step S30 determine whether a second indication signal is obtained; the second indication signal is used to indicate that the temperature of the microfluidic biochip is too low;
  • Step S40 heat the microfluidic biochip.
  • the reminder information can be, for example, voice information containing specific semantics, simple sound information such as beeps, etc., or light information, such as emitting light of a specific color, flashing light, etc.
  • the reminder information can also be other means of expressing to the user that the temperature of the microfluidic biochip is too high.
  • step S10 and S30 there is no strict sequence limit on the above steps S10 and S30, that is, they can be executed first Step S10 and then step S30 may be executed, or step S30 may be executed first and then step S10.
  • the control method of the microfluidic detection system of the present invention not only heats the microfluidic biochip when the second indication signal indicating that the temperature of the microfluidic biochip is too low is obtained, but also obtains the second indication signal indicating that the temperature of the microfluidic biochip is too low.
  • the first indication signal that the temperature of the microfluidic biochip is too high is detected, a reminder message is sent out in time, so that the user can take corresponding measures to cool down the microfluidic biochip, which not only avoids the detection of excessively low temperature of the microfluidic biochip. It also avoids the adverse effects of excessive temperature of the microfluidic biochip on the detection results, ensuring that the microfluidic detection system can obtain more accurate detection results in various usage environments.
  • the first indication signal and the second indication signal may be generated by:
  • the second indication signal is generated when the temperature of the microfluidic biochip is lower than the minimum endpoint value of the first preset temperature range.
  • the temperature of the microfluidic biochip can be directly obtained, and based on the obtained temperature value, it can be determined whether the temperature of the microfluidic biochip is too high or too low.
  • the obtained temperature value is higher than the maximum endpoint value of the first preset temperature range, it means that the temperature of the microfluidic biochip is too high; when the obtained temperature value is lower than the minimum endpoint value of the first preset temperature range , indicating that the temperature of the microfluidic biochip is too low.
  • FIG. 2 is a schematic flow chart of a control method of a microfluidic detection system according to another embodiment of the present invention.
  • the control method of the present invention includes:
  • Step S11 obtain the temperature of the microfluidic biochip
  • Step S12 determine whether the temperature of the microfluidic biochip is higher than the maximum endpoint value of the first preset temperature range; if so, go to step S20; if not, go to step S31;
  • Step S20 sending a reminder message indicating that the temperature of the microfluidic biochip is too high
  • Step S31 determine whether the temperature of the microfluidic biochip is lower than the minimum endpoint value of the first preset temperature range; if so, go to step S40; if not, return to step S11; and
  • Step S40 heat the microfluidic biochip.
  • the temperature of the buffer solution when the temperature of the buffer solution is within the first preset temperature range, it means that the temperature of the microfluidic biochip is appropriate, and there is no need to cool it or heat it.
  • the first indication signal and the second indication signal can also be obtained indirectly through other indirect methods, such as through the ambient temperature.
  • the first indication signal is generated when the ambient temperature is too high, and the first indication signal is generated when the ambient temperature is too low. Generate a second indication signal.
  • the microfluidic detection system further includes a heating device for heating the microfluidic biochip.
  • a heating device for heating the microfluidic biochip.
  • the inventor realized that the existing testing equipment is relatively large, and accordingly, the sample testing area is also relatively large. Temperature control is easier.
  • the microfluidic detection system is suitable for integration on refrigerators for home use because of its fast detection speed and small size. For smaller microfluidic detection systems, the size of the microfluidic biochip used is even smaller. Using ordinary heating control schemes, it is impossible to control its temperature stably, which will lead to serious temperature fluctuations and easily affect the accuracy of test results.
  • the step S40 of heating the microfluidic biochip may be include:
  • Step S41 determine the target duty cycle after the heating device is started based on the temperature of the microfluidic biochip.
  • Step S42 Control the operation of the heating device according to the target duty cycle.
  • the target duty cycle of the heating device can be expressed in percentage. For example, when the target duty cycle of the heating device is 40%, it means that within the preset time period, the heating device starts heating for 40% of the time and stops heating for 60% of the time.
  • the control method of the present invention selects different target duty cycles of the heating device according to the temperature of the microfluidic biochip.
  • the temperature of the microfluidic biochip is too low, When the temperature of the microfluidic biochip is slightly lower, a larger target duty cycle can be used to increase the heating speed, thereby shortening the time consumed by the entire detection and improving the detection efficiency.
  • the temperature of the microfluidic biochip when the temperature of the microfluidic biochip is slightly lower, it can be used
  • the smaller target duty cycle prevents the temperature of the microfluidic biochip from excessively increasing due to excessive heating speed, thereby avoiding large fluctuations in the temperature of the microfluidic biochip and increasing the temperature of the microfluidic biochip. Control stability.
  • a correspondence table between the temperature of the microfluidic biochip and the duty cycle of the heating device can be pre-stored in the microfluidic detection system, and it only needs to be matched to the corresponding target duty cycle based on the obtained temperature value.
  • the target duty cycle of the heating device when the temperature of the microfluidic biochip is less than the first preset temperature value, the target duty cycle of the heating device is the first preset duty cycle; when the temperature of the microfluidic biochip is greater than or equal to the th When a preset temperature value is less than or equal to the second preset temperature value, the target duty cycle of the heating device is the second preset duty cycle; when the temperature of the microfluidic biochip is greater than the second preset temperature value, the heating device The target duty cycle of the device is the third preset duty cycle.
  • the first preset temperature value is less than the second preset temperature value
  • the second preset temperature value is less than the minimum endpoint value of the first preset temperature range
  • the third preset duty cycle decreases sequentially.
  • FIG. 4 is a schematic diagram of a control method of a microfluidic detection system according to yet another embodiment of the present invention.
  • sexual flow chart In some embodiments, the control method of the present invention includes:
  • Step S11 obtain the temperature of the microfluidic biochip
  • Step S12 determine whether the temperature of the microfluidic biochip is higher than the maximum endpoint value of the first preset temperature range; if so, go to step S20; if not, go to step S31;
  • Step S20 sending a reminder message indicating that the temperature of the microfluidic biochip is too high
  • Step S31 determine whether the temperature of the microfluidic biochip is lower than the minimum endpoint value of the first preset temperature range; if so, go to step S40; if not, return to step S11; and
  • Step S411 determine whether the temperature of the microfluidic biochip is less than the first preset temperature value; if so, go to step S421; if not, go to step S412;
  • Step S421 control the operation of the heating device according to the first preset duty cycle
  • Step S412 determine whether the temperature of the microfluidic biochip is lower than the second preset temperature value; if yes, go to step S422; if not, go to step S423;
  • Step S422 control the operation of the heating device according to the second preset duty cycle
  • Step S423 Control the operation of the heating device according to the third preset duty cycle.
  • control method of the present invention after heating the microfluidic biochip, the control method of the present invention further includes:
  • the step of continuing to heat the microfluidic biochip may include:
  • the operation of the heating device is controlled according to the fourth preset duty cycle.
  • the step of restarting the heating device to reheat the microfluidic biochip may include:
  • the fourth preset duty cycle is less than or equal to the third preset duty cycle.
  • the temperature of the microfluidic biochip is close to the required First preset temperature range. If you need to continue heating the microfluidic biochip, you need to use a smaller third preset duty cycle or a fourth preset duty cycle smaller than the third preset duty cycle to control the operation of the heating device to avoid heating.
  • the faster speed causes the temperature of the microfluidic biochip to increase uncontrollably and excessively, thus further preventing undesired fluctuations in the temperature of the microfluidic biochip.
  • the temperature of the microfluidic biochip is already at or closer to the required first preset temperature range. If the temperature of the microfluidic biochip is slightly lowered and the microfluidic biochip needs to be heated again, it is also necessary to use a smaller third preset duty cycle or a fourth preset duty cycle smaller than the third preset duty cycle.
  • the air ratio controls the operation of the heating device to prevent the temperature of the microfluidic biochip from uncontrollably rising too much due to a fast heating speed, thereby further avoiding undesired fluctuations in the temperature of the microfluidic biochip.
  • Figure 5 is a schematic flow chart of a control method of a microfluidic detection system according to yet another embodiment of the present invention.
  • the control method of the present invention includes:
  • Step S11 obtain the temperature of the microfluidic biochip
  • Step S12 determine whether the temperature of the microfluidic biochip is higher than the maximum endpoint value of the first preset temperature range; if so, go to step S20; if not, go to step S31;
  • Step S20 sending a reminder message indicating that the temperature of the microfluidic biochip is too high
  • Step S31 determine whether the temperature of the microfluidic biochip is lower than the minimum endpoint value of the first preset temperature range; if so, go to step S40; if not, return to step S11; and
  • Step S411 determine whether the temperature of the microfluidic biochip is less than the first preset temperature value; if so, go to step S421; if not, go to step S412;
  • Step S421 control the operation of the heating device according to the first preset duty cycle
  • Step S412 determine whether the temperature of the microfluidic biochip is lower than the second preset temperature value; if yes, go to step S422; if not, go to step S423;
  • Step S422 control the operation of the heating device according to the second preset duty cycle
  • Step S423 Control the operation of the heating device according to the third preset duty cycle.
  • Step S51 continue to obtain the temperature of the microfluidic biochip
  • Step S52 determine whether the obtained temperature of the microfluidic biochip is greater than the maximum endpoint value of the second preset temperature range; if so, go to step S54; if not, go to step S53;
  • Step S53 control the operation of the heating device according to the fourth preset duty cycle, and return to step S51;
  • Step S54 stop the heating device
  • Step S55 obtain the temperature of the microfluidic biochip again
  • Step S56 determine whether the obtained temperature of the microfluidic biochip is less than the minimum endpoint value of the second preset temperature range; if so, go to step S57; if not, return to step S55;
  • Step S57 Start the heating device, control the operation of the heating device according to the fourth preset duty cycle, and return to step S51.
  • the maximum endpoint value of the first preset temperature range is the sum of the preset temperature threshold and the first temperature difference value
  • the minimum endpoint value of the first preset temperature range is the sum of the preset temperature threshold and the first temperature difference value. difference
  • the maximum endpoint value of the second preset temperature range is the sum of the preset temperature threshold and the second temperature difference value
  • the minimum endpoint value of the second preset temperature range is the difference between the preset temperature threshold and the second temperature difference value.
  • the first temperature difference value is greater than the second temperature difference value. That is to say, the first preset temperature range has a larger range. This is because when the microfluidic biochip is not heated at the beginning, the microfluidic biochip does not have any heat source and its temperature is stable.
  • the heating device After heating the microfluidic biochip, the heating device will generate a certain amount of heat. Even if the heating device stops, a certain amount of residual heat will be transferred to the microfluidic biochip. Therefore, the second preset temperature range prompts the heating device to stop.
  • the maximum endpoint value is slightly smaller than the maximum endpoint value of the first preset temperature range. In this way, after the heating device is stopped, the microfluidic biochip can be prevented from absorbing the waste heat of the heating device and causing the temperature to rise excessively.
  • the above-mentioned preset temperature threshold can be the optimal reaction temperature of the detection reagent used in the microfluidic detection system.
  • the values of the above-mentioned preset temperature thresholds are also different.
  • control method of the present invention before acquiring the first indication signal or the second indication signal, the control method of the present invention further includes:
  • the temperature of the microfluidic biochip should be monitored only after the microfluidic biochip is installed to avoid incomplete or completely inadequate installation of the microfluidic biochip from affecting the accuracy of temperature acquisition.
  • the temperature detection of the microfluidic biochip can run through the entire detection process of the microfluidic detection system, that is, from the insertion of the microfluidic biochip to the completion of detection.
  • FIG. 6 is a schematic structural block diagram of a microfluidic detection system according to an embodiment of the present invention
  • FIG. 7 is a schematic structural diagram of a microfluidic detection system according to an embodiment of the present invention.
  • the microfluidic detection system 10 of the present invention may specifically include a microfluidic biochip 12 , a prompting device 16 and a heating device 17 .
  • the microfluidic biochip 12 is used for sample liquid and detection reagents to react within it.
  • the prompting device 16 is used to send reminder information.
  • the heating device 17 is used to heat the microfluidic biochip 12 .
  • the microfluidic detection system 10 also includes a control device 18, and the prompting device 16 and the heating device 17 are both connected to the control device 18.
  • the control device 18 includes a processor 181 and a memory 182, which stores There is a machine executable program 183, and when executed by the processor 181, the machine executable program 183 is used to implement the control method described in any of the above embodiments.
  • the processor 181 may be a central processing unit (CPU for short), or a digital processing unit, or the like.
  • the processor 181 sends and receives data through the communication interface.
  • the memory 182 is used to store programs executed by the processor 181 .
  • Memory 182 is any medium that can be used to carry or store desired program code in the form of instructions or data structures and that can be accessed by a computer, or can be a combination of multiple memories.
  • the above-mentioned machine executable program 183 can be downloaded from a computer-readable storage medium to a corresponding computing/processing device or to a computer or external storage device via a network (such as the Internet, a local area network, a wide area network and/or a wireless network).
  • the microfluidic detection system 10 also includes a temperature sensor 19 , which is disposed at the microfluidic biochip 12 and used to obtain the temperature of the microfluidic biochip 12 .
  • the heating device 17 and the temperature sensor 19 are both arranged outside the microfluidic biochip 12 and fixed on the mounting mechanism of the microfluidic biochip 12 .
  • the microfluidic detection system 10 may also optionally include a buffer storage tank 11 for storing detection buffer, a sample stage 13 for placing the sample cup 2, and a buffer storage tank for driving the buffer storage tank.
  • the buffer in 11 flows to the buffer driving device 14 of the sample cup, the sample liquid driving device 15 for driving the sample liquid into the microfluidic biochip 12, and so on.
  • the sample cup 2 is used for users to place samples, receive buffer driven by the buffer driving device, etc.
  • the buffer driving device 14 drives the buffer in the buffer storage tank 11 to flow to the sample cup 2.
  • a sample liquid is formed, and the sample liquid driving device 15 drives the sample liquid into the microfluidic biochip 12 and then completes reactions, detection, etc. in the microfluidic biochip 12 .
  • the present invention also provides a refrigerator.
  • Figure 8 is a schematic structural diagram of the refrigerator according to an embodiment of the present invention.
  • the refrigerator 1 of the present invention includes a box body 20 and a door body 30 .
  • the box 20 defines a storage compartment for storing items.
  • the door 30 is connected to the box 20 to open and/or close the storage compartment.
  • the refrigerator 1 also includes the microfluidic detection system 10 described in any of the above embodiments, and the microfluidic detection system 10 is provided on the box 20 or the door 30 .
  • microfluidic detection system 10 can be electrically connected to the electrical control device of the refrigerator 1 to provide power for the microfluidic detection system 1 through the electrical control device and/or allow communication between the electrical control device and the microfluidic detection system 1 Transmission signal.
  • the microfluidic detection system 10 is preferably arranged on the door body 30, which is not only more convenient to operate, but also Moreover, the original storage space in the box 20 will not be occupied, and the storage capacity of the refrigerator 1 itself will not be affected.
  • the refrigerator 1 of the present invention is integrated with a microfluidic detection system 10, which facilitates the popularization of food detection into ordinary family life, and facilitates the use of the environment in the refrigerator 1 to cool down the microfluidic biochip 12, thereby improving user convenience.
  • connection should be understood in a broad sense.
  • connection or integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, an indirect connection through an intermediate medium, or an internal connection between two components.
  • connection or integral connection
  • connection or integral connection
  • connection can be a mechanical connection or an electrical connection
  • it can be a direct connection, an indirect connection through an intermediate medium, or an internal connection between two components.
  • first”, “second” and “third” are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

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  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Thermal Sciences (AREA)
  • Combustion & Propulsion (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Automation & Control Theory (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Plasma & Fusion (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

La présente invention concerne un système de détection microfluidique et son procédé de commande, ainsi qu'un réfrigérateur. Le système de détection microfluidique comprend une biopuce microfluidique dans laquelle une solution d'échantillon et un réactif de détection réagissent. Le procédé de commande de la présente invention comprend les étapes suivantes : lorsqu'un premier signal d'indication est acquis, envoyer des informations d'avertissement utilisées pour indiquer que la température d'une biopuce microfluidique est excessivement élevée, le premier signal d'indication étant utilisé pour indiquer que la température de la biopuce microfluidique est excessivement élevée ; et lorsqu'un second signal d'indication est acquis, chauffer la biopuce microfluidique, le second signal d'indication étant utilisé pour indiquer que la température de la biopuce microfluidique est excessivement faible.
PCT/CN2023/084383 2022-04-02 2023-03-28 Système de détection microfluidique et procédé de commande associé, et réfrigérateur WO2023185839A1 (fr)

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CN202210350940.8 2022-04-02
CN202210350940.8A CN116928972A (zh) 2022-04-02 2022-04-02 微流控检测系统及其控制方法、冰箱

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1995319A (zh) * 2007-01-12 2007-07-11 北京工业大学 面向聚合酶链式反应微流控芯片的多通道智能温控装置
CN102886280A (zh) * 2012-08-28 2013-01-23 博奥生物有限公司 一种微流控芯片及其应用
CN102937363A (zh) * 2012-10-30 2013-02-20 合肥美菱股份有限公司 一种冰箱翻转梁的防凝露加热控制装置及其控制方法
US20180178217A1 (en) * 2015-06-05 2018-06-28 Miroculus Inc. Evaporation management in digital microfluidic devices
CN214039110U (zh) * 2020-09-27 2021-08-24 青岛海尔电冰箱有限公司 冰箱

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1995319A (zh) * 2007-01-12 2007-07-11 北京工业大学 面向聚合酶链式反应微流控芯片的多通道智能温控装置
CN102886280A (zh) * 2012-08-28 2013-01-23 博奥生物有限公司 一种微流控芯片及其应用
US20150217290A1 (en) * 2012-08-28 2015-08-06 Capitalbio Corporation Microfluidic chip and application thereof
CN102937363A (zh) * 2012-10-30 2013-02-20 合肥美菱股份有限公司 一种冰箱翻转梁的防凝露加热控制装置及其控制方法
US20180178217A1 (en) * 2015-06-05 2018-06-28 Miroculus Inc. Evaporation management in digital microfluidic devices
CN214039110U (zh) * 2020-09-27 2021-08-24 青岛海尔电冰箱有限公司 冰箱

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