WO2023163312A1 - Module, dispositif et système de surveillance de perfusion de médicament - Google Patents

Module, dispositif et système de surveillance de perfusion de médicament Download PDF

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Publication number
WO2023163312A1
WO2023163312A1 PCT/KR2022/016653 KR2022016653W WO2023163312A1 WO 2023163312 A1 WO2023163312 A1 WO 2023163312A1 KR 2022016653 W KR2022016653 W KR 2022016653W WO 2023163312 A1 WO2023163312 A1 WO 2023163312A1
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Prior art keywords
flow
drug injection
thin plate
temperature
pressure
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PCT/KR2022/016653
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English (en)
Korean (ko)
Inventor
도일
조주형
최병문
Original Assignee
한국표준과학연구원
울산대학교 산학협력단
재단법인 아산사회복지재단
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Application filed by 한국표준과학연구원, 울산대학교 산학협력단, 재단법인 아산사회복지재단 filed Critical 한국표준과학연구원
Publication of WO2023163312A1 publication Critical patent/WO2023163312A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16877—Adjusting flow; Devices for setting a flow rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16886—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body for measuring fluid flow rate, i.e. flowmeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/36—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/36—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body
    • A61M5/365—Air detectors
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A61M2205/3334—Measuring or controlling the flow rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3368—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient

Definitions

  • the present invention relates to a module, device, and system for monitoring the injection status of a drug in a drug infusion pump, and more particularly, to a drug injection monitoring module, device, and system for measuring a flow rate of drug injection.
  • a technology for measuring and monitoring the flow rate of a fluid in real time and controlling the flow rate accordingly is widely used throughout industries such as medical, semiconductor, 3D printing, mold, and bio fields.
  • MEMS microminiature precision machines
  • drug injection monitoring means checking the physical state of the drug in the tube delivered to the human body through the drug injection pump, such as flow rate, pressure, bubble detection, and the like.
  • the deviation of the measured value is very large, more than 20%, depending on the friction between the syringe plunger and the syringe pump and the physical properties of the tube of the volumetric injection pump.
  • each individual sensor for flow rate, pressure, and bubble detection can be developed and applied to develop a drug injection monitoring module, but the reliability of the module due to the complexity of electrical and fluid connections in each sensor as well as the increase in manufacturing cost this will fall
  • Patent Document 2 Patent Publication No. 10-1824866 (2018.02.05.)
  • An object of the present invention to solve the above problems is to measure the flow rate by the temperature change on both sides of the heater according to the flow of the drug, measure the strain of the thin film due to the pressure of the drug, and measure the conductivity of the drug by bubbles and to provide a drug injection monitoring module, device, and system capable of detecting a change in permittivity to detect flow rate and air bubbles, lowering manufacturing cost, and sufficiently securing reliability.
  • the thin plate body provided with the flow passage of the fluid; a heating unit located in the flow passage of the thin plate body; a plurality of temperature sensing units located in the flow passage and spaced apart from the heating unit in the thin plate body; and a deformation sensor disposed on the thin plate body and detecting deformation of the thin plate body.
  • the thin plate body, the heating unit and a plurality of temperature sensing units are provided in a pattern shape, the thin plate sensor provided with the flow passage; And doedoe coupled to the thin plate sensor, it may include a circuit board to which the heating unit and the temperature sensing unit are connected.
  • the plurality of temperature sensing units may include a first temperature resistance pattern spaced apart from one side of the heating unit; and a second temperature resistance pattern spaced apart from the other side of the heating unit.
  • the deformation sensor may be provided as a piezoresistive sensor.
  • the deformation sensor may be located on the corner side of the thin plate. At this time, in order to prevent heat transfer from the heating unit, it may be located at a corner in a fluid flow direction.
  • the drug injection monitoring module described above a flow controller connected to the flow passage of the drug injection monitoring module and controlling the flow rate of the fluid; a power supply unit connected to a heating unit and a plurality of temperature sensing units of the drug injection monitoring module; and measuring a current passing through the plurality of temperature sensing units, calculating a flow rate passing through the flow passage based on a current difference between the plurality of temperature sensing units, and being connected to the deformation sensor to determine the flow rate of the fluid passing through the flow passage.
  • a flow and pressure measurement unit for calculating a flow pressure based on a current change of the strain sensor; It is possible to provide a drug injection monitoring device comprising a.
  • the power supply unit may include a first power supply unit that is connected to the heating unit to supply current; and a second power supply unit connected to the plurality of temperature sensing units to supply current.
  • the flow rate and pressure measuring unit a current meter provided with a plurality of measuring ports corresponding to the plurality of temperature sensing units and strain sensors; and a microcontroller connected to the current meter to receive current change values corresponding to the plurality of temperature sensors and strain sensors, calculate flow rate and pressure, and output the calculated value; can include
  • the drug injection monitoring device a server communicatively connected to the microcontroller; a flow and pressure monitoring platform mounted on the server, displaying the flow rate and pressure output from the microcontroller, alerting an abnormal change in the flow rate and pressure, and controlling the flow controller; And a terminal equipped with a flow and pressure monitoring app that is communicatively connected to the server, accesses the flow and pressure monitoring platform to receive flow and pressure information, and is provided to control the flow regulator;
  • a drug injection monitoring device including a may be provided.
  • the effect of the present invention according to the configuration as described above is to measure the flow rate by the temperature change on both sides of the heater according to the flow of the drug, measure the strain of the thin film due to the pressure of the drug, and measure the conductivity and permittivity of the drug by bubbles. It is possible to provide a drug injection monitoring module, device, and system capable of detecting a change in flow rate and bubble detection, reducing manufacturing cost, and sufficiently securing reliability.
  • FIG. 1 is a conceptual diagram of a drug injection monitoring module according to an embodiment of the present invention.
  • FIG. 2 is a cross-sectional view A-A of FIG. 1 .
  • FIG. 3 is an enlarged view of a heating unit and a temperature sensing unit of FIG. 1 .
  • FIG. 4 is a conceptual diagram of a drug injection monitoring device according to an embodiment of the present invention.
  • FIG. 5 is a conceptual diagram of a drug injection monitoring system according to an embodiment of the present invention.
  • FIG. 6 is a graph showing a change in temperature of the temperature sensor according to the flow of fluid and bubbles in the drug injection monitoring device according to an embodiment of the present invention.
  • the thin plate body provided with the flow passage of the fluid; a heating unit located in the flow passage of the thin plate body; a plurality of temperature sensing units located in the flow passage and spaced apart from the heating unit in the thin plate body; and a deformation sensor disposed on the thin plate body and detecting deformation of the thin plate body.
  • FIG. 1 is a conceptual diagram of a drug injection monitoring module according to an embodiment of the present invention
  • FIG. 2 is an A-A cross-sectional view of FIG. 1
  • FIG. 3 is an enlarged view of a heating unit and a temperature sensing unit of FIG. 1 .
  • the drug injection monitoring module 100 includes a thin plate body 101 provided with a fluid flow passage 102, a flow passage of the thin plate body 101 ( 102), a plurality of temperature sensing units 120 located in the flow passage 102 and spaced apart from the heating unit 110 in the thin plate body 101, and located in the thin plate body 101 and a deformation sensor 130 for detecting deformation of the thin plate body 101.
  • a heating unit 110 and a plurality of temperature sensing units 120 are provided in a pattern shape and coupled to the thin plate sensor 105 provided with a flow passage 102 and the thin plate sensor 105, and the heating unit It may include a circuit board 106 to which 110 and temperature sensor 120 are connected.
  • the thin plate sensor 105 is made of an insulating plate made of an insulating material having a flow passage 102 provided to sense the mass flow rate and pressure of the fluid, and the flow passage 102 penetrates the lower part from the upper surface of one side and connects to the upper surface of the other side. formed so that
  • the flow passage 102 is a passage through which a fluid such as a drug passes, and may have a square or circular cross-sectional shape corresponding to the heating unit 110 and the plurality of temperature sensing units 120, but is not limited thereto.
  • a heating unit 110 for heating the fluid and a plurality of temperature sensing units for measuring the temperature difference between the upstream side and the downstream side of the fluid passing through the heating unit 110 120: 121, 122 is located.
  • the heating unit 110 generates heat by a specific resistance while conducting electricity, and is disposed in the shape of a membrane heater pattern, and preferably, a current between 1 mA and 5 mA can pass therethrough.
  • the plurality of temperature sensing units 120 include a first temperature resistance pattern 121 spaced apart from one side of the heating unit 110 and a second temperature resistance pattern located spaced apart from the other side of the heating unit 110 ( 122) is provided.
  • the first temperature resistance pattern 121 and the second temperature resistance pattern 122 are positioned with the heating unit 110 interposed therebetween to sense the temperature of the fluid passing through the flow passage 102 at each position.
  • the first temperature resistance pattern 121 and the second temperature resistance pattern 122 have a resistance change according to temperature, and when resistance is measured after providing a constant current, a corresponding temperature is measured.
  • the plurality of temperature sensing units 120 pass a current between 0.001 mA and 1 mA, and self-heat (self-heating) by supplying a low current (less than 1 mA) for resistance measurement using the principle that the resistance of metal is proportional to the temperature. -heating) does not occur.
  • the heat generated by the heating unit 110 is transferred to the fluid passing through the flow passage 102, a temperature difference is generated in the two temperature sensing units 121 and 122.
  • the two temperature sensing units The flow rate may be calculated based on the degree of temperature rise of the passing fluid based on the temperature difference measured in the units 121 and 122 .
  • the fluid does not flow through the flow passage 102 while current is supplied to the heating unit 110, there is no temperature difference due to symmetrical heat transfer.
  • the temperature of the first temperature resistance pattern 121 decreases and the second temperature resistance pattern 122
  • the temperature difference due to the temperature rise of - a value obtained by subtracting the temperature of the first temperature resistance pattern 121 from the temperature of the second temperature resistance pattern 122 - has a positive value.
  • a temperature difference between the first temperature resistance pattern 121 and the second temperature resistance pattern 122 appears as a negative value.
  • the temperature of the heating unit 110 rises rapidly and the temperature of the temperature sensing unit on one side of the passage rapidly changes instantaneously.
  • the heating unit 110 and the temperature sensing unit detect a temperature change equal to or greater than a threshold value to determine whether there are bubbles, and measure the duration of the abnormal state to predict the volume of bubbles.
  • the volume of the bubbles located in the flow passage 102 is measured using the time difference of the signal at which the rapid temperature change occurs in the temperature sensor as described above. It can be done, and a more detailed process of measuring the volume of bubbles is as follows.
  • the temperature change according to the passage of the bubbles is relatively In the second temperature resistance pattern 122, which is not large and is located behind the flow passage 102, that is, behind the heating unit 110, the temperature not only rises at a later time as bubbles pass through, but also the temperature rises. The amount of change is also relatively large.
  • the section (time change amount) in which the temperature of the first temperature resistance pattern 121 and the second temperature resistance pattern 122 rises according to the time change in which the fluid and bubbles flow may be formed in the same manner.
  • the drug injection pump supplies the fluid at a constant flow rate, so the flow rate of the fluid flowing in the flow passage 102 does not change, so each temperature resistance pattern (temperature detection) After detecting whether or not there are bubbles according to the rapid temperature rise in part), the volume of bubbles present in the fluid can be measured through (temperature rise section time) ⁇ (cross-sectional area of the flow path) ⁇ (flow rate immediately before bubble detection) .
  • the heating unit 110 controls the fluid temperature higher than a certain temperature detected by the ambient temperature sensing unit, and the difference in resistance between the upstream and downstream temperature sensing units of the flow passage 102 at that time is made of a resistance bridge.
  • the voltage difference of the sensor output circuit can be captured.
  • the temperature distribution on the upstream and downstream sides of the heating unit 110 is uniform, and when there is flow, the symmetry of the temperature distribution is broken.
  • the temperature difference (resistance difference) between the plurality of temperature sensing units 120 on the upstream side and the downstream side becomes a function of the mass flow rate (defined as flow rate U ⁇ density ⁇ ) of the gas flowing on the upper surface of the sensor.
  • the deformation sensor 130 may be provided as a piezoresistive sensor, and may be located at a corner side of the thin plate body 101 of the heating unit 110 or the temperature sensing unit 120 .
  • the deformation sensor 130 provided as a resistor at the edge of the thin plate is piezoresistive, so the change in resistance is sensed. do.
  • the deformation sensor 130 may detect the deformation of the thin plate near the upstream and downstream sides of the flow passage 102, and the fluid
  • the strain sensor 130 uses the temperature sensing unit 120, that is, the first temperature resistance pattern 121 and the second It may be positioned adjacent to the temperature resistance pattern 122 .
  • the drug injection monitoring module 100 measures the flow rate according to the temperature difference between the plurality of temperature detectors 120 by the temperature change on both sides of the heating unit 110, which is a heater according to the flow of the drug.
  • the strain of the thin plate due to the pressure of the drug can be measured by the resistance value of the strain sensor 130, and the change in conductivity and permittivity of the drug due to the bubble can be detected to make it possible to detect the bubble.
  • FIG. 4 is a conceptual diagram of a drug injection monitoring device according to an embodiment of the present invention.
  • the drug injection monitoring device 200 according to another embodiment of the present invention is provided in the drug injection monitoring module 100 and the flow passage 102 of the drug injection monitoring module 100.
  • a flow controller 210 that is connected and controls the flow rate of fluid, a power supply unit 220 connected to the heating unit 110 of the drug injection monitoring module 100 and a plurality of temperature sensing units 120, respectively, and a plurality of temperature sensing units It is connected to the unit 120 and the strain sensor 130 and includes a flow rate and pressure measuring unit 230 for calculating the flow rate and pressure.
  • the flow controller 210 is disposed in the injection line of the drug injected into the human body through the drug injection motoring module 100 in the drug infusion pump to control the flow rate.
  • the power supply unit 220 is provided to supply current corresponding to the heating unit 110 and the plurality of temperature sensing units 120, and to supply current corresponding to the heating unit 110 and the plurality of temperature sensing units 120. It is provided with a plurality of power supply lines for
  • the power supply unit 220 is connected to the first power supply unit 220 that is connected to the heating unit 110 to supply a current of 1 mA to 5 mA, and to the plurality of temperature sensing units 120 to supply a current of 0.001 mA to 1 mA. It may include a second power supply unit 220 that supplies.
  • the flow and pressure measuring unit 230 measures one or more of current and voltage passing through the plurality of temperature sensing units 120 or resistance, and measures one or more of the current and voltage or resistance of the plurality of temperature sensing units 120. Calculate the flow rate passing through the flow passage 102 based on the difference of , and is connected to the deformation sensor 130 and is connected to one or more of current and voltage or resistance of the deformation sensor 130 according to the passage of the fluid in the flow passage 102 Arranged to calculate the flow pressure based on the change.
  • the flow and pressure measuring unit 230 is connected to a plurality of temperature sensing units 120 and a plurality of measuring ports corresponding to the deformation sensor 130, and a current measuring instrument 231, and a current measuring instrument 231. It may include a microcontroller 235 that receives a current change value corresponding to the temperature sensor 120 and the strain sensor 130 of the input, and calculates and outputs the flow rate and pressure.
  • the current meter 231 may be provided to measure both voltage and resistance changes, and the microcontroller 235 measures current, resistance, and voltage changes according to changes in temperature and pressure of the fluid passing through the flow passage 102. A function program that can be calculated is loaded.
  • microcontroller 235 may be connected to the flow controller 210 to control the flow controller 210 .
  • the drug injection monitoring device 200 includes the above-described drug injection monitoring module 100 installed in the drug injection line, the flow controller 210, and the flow and pressure measuring unit 230 so that the drug is injected through the drug injection line. This makes it a constant injection.
  • the microcontroller 235 is connected to the drug injection monitoring module 100 to monitor in real time the mass flow rate and pressure of the drug passing through the flow passage 102 connected to the drug injection line, and detects the injection of an abnormal state.
  • the flow controller 210 may be controlled to block drug injection or maintain and/or restore a constant drug injection amount.
  • FIG. 5 is a conceptual diagram of a drug injection monitoring system 300 according to an embodiment of the present invention.
  • the drug injection monitoring system 300 includes the above-described drug injection monitoring device 200, a server 310 communicatively connected to the microcontroller 235, It may include a flow and pressure monitoring platform 320 mounted on the server 310 and a terminal 330 communicatively connected to the server 310 .
  • the flow and pressure monitoring platform 320 displays the flow rate and pressure output from the microcontroller 235, alerts abnormal changes in the flow rate and pressure, and uses the microcontroller 235 to control the flow regulator 210. Equipped with software controllable monitoring management control and communication programs.
  • the flow and pressure monitoring platform 320 may configure a network in which several drug injection monitoring devices 200 are connected, and monitor the environment according to the drug injection state of each flow and pressure monitoring device 200.
  • the drug corresponding to the patient's condition is adaptively injected.
  • This flow and pressure monitoring platform 320 is not only implemented to enable direct management through which a nurse or doctor can properly intervene through an interface, but also is equipped with an automatic monitoring program or artificial intelligence to enable fine adjustment of drug injection in real time. It can be.
  • Artificial intelligence can be prepared to create a database by monitoring the appropriate drug injection amount and condition according to the condition of various patients, and to perform machine learning that can be combined with machine learning that can derive the optimal drug injection based on the database. there is.
  • the terminal 330 is communicatively connected to the server 310, accesses the flow and pressure monitoring platform 320, receives flow and pressure information, and has a flow and pressure monitoring app 340 provided to control the flow regulator 210. It may include a built-in patient management computer or a smart phone dedicated to patient management equipped by a nurse or doctor.
  • the drug injection monitoring module which is a single sensor, to detect the mass flow rate and pressure of the drug, thereby reducing the manufacturing cost. It is possible to increase the reliability of the sensor module, and by expanding and implementing it into a drug injection monitoring device and system that connects it to a device such as a drug infusion pump, it is possible to inject drugs in a fixed amount and manage abnormal conditions. It provides the advantage of increasing the efficiency of remote monitoring management.

Abstract

Un mode de réalisation de la présente invention concerne un module de surveillance de perfusion de médicament, un dispositif de surveillance de perfusion de médicament et un système de surveillance de perfusion de médicament. Le module de surveillance de perfusion de médicament selon un mode de réalisation de la présente invention comprend : un corps de plaque mince présentant un passage d'écoulement de fluide ; une unité de chauffage disposée dans le passage d'écoulement du corps de plaque mince ; une pluralité d'unités de détection de température disposées dans le passage d'écoulement tout en étant espacées de l'unité de chauffage dans le corps de plaque mince ; et un capteur de contrainte disposé dans le corps de plaque mince et détectant la contrainte du corps de plaque mince.
PCT/KR2022/016653 2022-02-25 2022-10-28 Module, dispositif et système de surveillance de perfusion de médicament WO2023163312A1 (fr)

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KR1020220025054A KR20230127579A (ko) 2022-02-25 2022-02-25 약물 주입 모니터링 모듈, 장치 및 시스템
KR10-2022-0025054 2022-02-25

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US20110066108A1 (en) * 2009-09-11 2011-03-17 Roche Diagnostics International Ag Micro-fluidic chambers for use in liquid medicament delivery systems
WO2016137826A1 (fr) * 2015-02-23 2016-09-01 Memsic, Inc. Capteur de flux thermique de mems à compensation de composition de fluide
KR20190061318A (ko) * 2017-11-27 2019-06-05 재단법인 대구경북첨단의료산업진흥재단 약물 주입 장치

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