WO2023161008A1 - Composition d'hygiène - Google Patents
Composition d'hygiène Download PDFInfo
- Publication number
- WO2023161008A1 WO2023161008A1 PCT/EP2023/052918 EP2023052918W WO2023161008A1 WO 2023161008 A1 WO2023161008 A1 WO 2023161008A1 EP 2023052918 W EP2023052918 W EP 2023052918W WO 2023161008 A1 WO2023161008 A1 WO 2023161008A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- bacillus
- chloride
- bacterial spores
- combination
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 116
- 210000004666 bacterial spore Anatomy 0.000 claims abstract description 29
- 239000003093 cationic surfactant Substances 0.000 claims abstract description 16
- 244000052616 bacterial pathogen Species 0.000 claims abstract description 11
- 239000004744 fabric Substances 0.000 claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000002736 nonionic surfactant Substances 0.000 claims description 11
- 238000004140 cleaning Methods 0.000 claims description 10
- 230000003750 conditioning effect Effects 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 241000193744 Bacillus amyloliquefaciens Species 0.000 claims description 9
- 241000194107 Bacillus megaterium Species 0.000 claims description 9
- 241000194103 Bacillus pumilus Species 0.000 claims description 9
- 244000063299 Bacillus subtilis Species 0.000 claims description 9
- 235000014469 Bacillus subtilis Nutrition 0.000 claims description 9
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 claims description 9
- -1 alkyl dimethyl benzylammonium chloride Chemical compound 0.000 claims description 9
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 claims description 9
- 229960004670 didecyldimethylammonium chloride Drugs 0.000 claims description 9
- 241000193388 Bacillus thuringiensis Species 0.000 claims description 7
- 229940097012 bacillus thuringiensis Drugs 0.000 claims description 7
- 229960001950 benzethonium chloride Drugs 0.000 claims description 6
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 6
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 6
- WOWHHFRSBJGXCM-UHFFFAOYSA-M cetyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C WOWHHFRSBJGXCM-UHFFFAOYSA-M 0.000 claims description 6
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 239000000919 ceramic Substances 0.000 claims description 3
- 229960000800 cetrimonium bromide Drugs 0.000 claims description 3
- REZZEXDLIUJMMS-UHFFFAOYSA-M dimethyldioctadecylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC REZZEXDLIUJMMS-UHFFFAOYSA-M 0.000 claims description 3
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 14
- 210000004215 spore Anatomy 0.000 description 12
- 150000004665 fatty acids Chemical class 0.000 description 11
- 229960000686 benzalkonium chloride Drugs 0.000 description 9
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- 239000002979 fabric softener Substances 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 235000014113 dietary fatty acids Nutrition 0.000 description 6
- 229930195729 fatty acid Natural products 0.000 description 6
- 239000000194 fatty acid Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 238000005406 washing Methods 0.000 description 6
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 5
- 239000002304 perfume Substances 0.000 description 5
- 239000003352 sequestering agent Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 4
- 230000000845 anti-microbial effect Effects 0.000 description 4
- 239000004599 antimicrobial Substances 0.000 description 4
- 239000000460 chlorine Substances 0.000 description 4
- 229910052801 chlorine Inorganic materials 0.000 description 4
- 150000002191 fatty alcohols Chemical class 0.000 description 4
- 230000000813 microbial effect Effects 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- 239000007844 bleaching agent Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000000645 desinfectant Substances 0.000 description 3
- 230000000249 desinfective effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 150000002194 fatty esters Chemical class 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical group OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 239000008139 complexing agent Substances 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 238000004900 laundering Methods 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 230000005923 long-lasting effect Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 229920005573 silicon-containing polymer Polymers 0.000 description 2
- 239000008247 solid mixture Substances 0.000 description 2
- 230000003019 stabilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- QIVUCLWGARAQIO-OLIXTKCUSA-N (3s)-n-[(3s,5s,6r)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2-oxospiro[1h-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide Chemical compound C1([C@H]2[C@H](N(C(=O)[C@@H](NC(=O)C=3C=C4C[C@]5(CC4=NC=3)C3=CC=CN=C3NC5=O)C2)CC(F)(F)F)C)=C(F)C=CC(F)=C1F QIVUCLWGARAQIO-OLIXTKCUSA-N 0.000 description 1
- 241000194108 Bacillus licheniformis Species 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 102100026816 DNA-dependent metalloprotease SPRTN Human genes 0.000 description 1
- 101710175461 DNA-dependent metalloprotease SPRTN Proteins 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 150000001204 N-oxides Chemical class 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000011358 absorbing material Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 230000003214 anti-biofilm Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000032770 biofilm formation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 150000005690 diesters Chemical class 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000004851 dishwashing Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
- 239000003752 hydrotrope Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 230000000529 probiotic effect Effects 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005201 scrubbing Methods 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/38—Cationic compounds
- C11D1/62—Quaternary ammonium compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/835—Mixtures of non-ionic with cationic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
- C11D17/0008—Detergent materials or soaps characterised by their shape or physical properties aqueous liquid non soap compositions
- C11D17/0013—Liquid compositions with insoluble particles in suspension
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/001—Softening compositions
- C11D3/0015—Softening compositions liquid
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/381—Microorganisms
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
Definitions
- the present invention relates to a composition that is used to deliver hygiene on surfaces.
- the present invention relates to a composition that delivers immediate kill of germs as well as over extended period of time which is evident from being able to solve the really difficult problem of biofilm removal.
- Making hard surfaces hygienic is important for people inhabiting homes and using other common spaces like offices, restaurants, hotels and public places like bus and train stations and airports. This generally involves using a disinfectant composition that is diluted with water before use. Horizontal surfaces are disinfected by applying the diluted composition. They may then be left to air dry or are wiped dry with a clean cloth or mop. Vertical surfaces may be similarly disinfected by spraying the composition on to the surface followed optionally by wiping. Hard surfaces in such places include utensils which may be made of steel, ceramic, glass etc. Other important hard surfaces in such places include floors, walls, windows, kitchen platforms, and furniture among others. Such places also, many a time, remain with an unpleasant stain after the step of cleaning, in spite of use of products having very good cleaning and disinfecting agents included therein.
- Toilets and bathrooms are places which especially require very frequent cleaning and disinfection as they are places for excrement and personal cleansing.
- Toilet cleaners include harsher chemicals like bleaches and strong antimicrobial actives which are not often liked by many consumers.
- Washing fabrics which have soft surfaces, also known as laundering or simply as laundry is a daily chore for most people.
- a fabric is washed by contacting it with a detergent composition either in neat or diluted form, rinsing the fabric one or more times with water; and finally, drying it.
- the fabric is rinsed free of the composition using copious amounts of water, two or three time.
- fabric conditioning compositions may be added in the rinse stage, usually during the last rinse stage.
- Biofilms are microbial aggregates which include heterogeneous populations of bacteria, fungi, and algae. They are ubiquitous in nature and represent populations of cells that have functional interdependencies upon one another which collectively offer microbial activities that are not possible by any of the individual component species.
- the biofilm matrix surrounding bacteria and fungi makes them tolerant to harsh conditions and resistant to antimicrobial treatments.
- the formation of microbial biofilm presents a challenge to the establishment and maintenance of hygienic conditions in public health, the home and in industry.
- biofilms are formed on surfaces which include kitchen surfaces, drainages and sinks, dishwash sponges, refrigerators, washing machines, toilets, damp surfaces and ceilings and poses a threat to human health. Biofilms can thus form on hard as well as on soft surfaces.
- the occurrence of many biofilm-based infections and their multiple antimicrobial resistance is a major concern to human health. It is critically important to design or screen anti-biofilm molecules or compositions that can effectively minimize and eradicate biofilm related infections.
- US6165965 (2000, Spartan) discloses an aqueous disinfectant and hard surface cleaning composition comprising an effective disinfecting amount of a quaternary ammonium compound; an effective amount of a spore forming microbial composition; and an effective water dispersing amount of a surfactant.
- the first aspect of the present invention relates to a hygiene composition
- a hygiene composition comprising
- cationic surfactant is selected from one or more of alkyl dimethyl benzylammonium chloride (ADBAC), bis (C8-C18) alkyl di methyl quaternary ammonium chloride preferably didecyl dimethyl ammonium chloride (DDAC), cetyl trimethyl ammonium chloride (CTAC), cetyl pyridinium chloride (CPC), cetrimonium bromide, benzethonium chloride (BZE); and dimethyldioctadecylammonium chloride.
- ADBAC alkyl dimethyl benzylammonium chloride
- DDAC didecyl dimethyl ammonium chloride
- CTC cetyl trimethyl ammonium chloride
- CPC cetyl pyridinium chloride
- BZE cetrimonium bromide, benzethonium chloride
- a method of ensuring immediate kill of germs as well as biofilm disruption comprising the step of contacting the desired surface with a composition of the first aspect preferably diluted with water.
- any feature of one aspect of the present invention may be utilised in any other aspect of the invention.
- the word “comprising” is intended to mean “including” but not necessarily “consisting of” or “composed of”.
- the term “comprising” is meant not to be limiting to any subsequently stated elements, but rather to optionally also encompass nonspecified elements of major or minor functional importance. In other words, the listed steps or options need not be exhaustive. Whenever the words “including” or “having” are used, these terms are meant to be equivalent to “comprising” as defined above. It is noted that the examples given in the description below are intended to clarify the invention and are not intended to limit the invention to those examples per se.
- composition of the invention includes a cationic surfactant selected from one or more of alkyl dimethyl benzylammonium chloride (ADBAC) which is also known as benzalkonium chloride (BKC), bis (C8-C18) alkyl di methyl quaternary ammonium chloride preferably didecyl dimethyl ammonium chloride (DDAC), cetyl trimethyl ammonium chloride (CTAC), cetyl pyridinium chloride (CPC), cetrimonium bromide, benzethonium chloride (BZE); and dimethyldioctadecylammonium chloride.
- ADBAC alkyl dimethyl benzylammonium chloride
- BKC benzalkonium chloride
- CTC cetyl trimethyl ammonium chloride
- CPC cetyl pyridinium chloride
- BZE cetrimonium bromide, benzethonium chloride
- the cationic surfactant to be chosen from one or more of BKC or DDAC, preferably BKC. They are available as a single quaternary ammonium compound, as well as mixtures of two or more different quaternary ammonium compounds e.g. under trademarks BARDACTM, BARQUAT® and HYAMINE® (all by Lonza); and BTC® (by Stepan).
- Quaternary ammonium compounds available as a single quaternary ammonium compound include didecyl dimethyl ammonium chloride (available as BARDACTM 2250 R and BTC® 1010, both 50% active; and BARDACTM 2280 R and BTC® 1010-80, both 80% active), alkyl dimethyl benzyl ammonium chloride (available as BARQUAT® MB-50, BARQUAT® MX-50, BARQUAT® QJ-50, HYAMINE® 3500, BTC® 50, BTC® 50E, BTC® 65, BTC® 776, BTC® 824, BTC® 835; each 50% active; and the same is available as BARQUAT® MB-80, BARQUAT® MX-80, HYAMINE® 3500-80, BTC® 8248, BTC® 8358; each 80% active
- the cationic surfactant is included in at least 0.005%, preferably at least 0.01%, more preferably at least 0.05% and most preferably at least 0.1% by weight of the composition.
- the cationic surfactant is included in at most 0.5%, more preferably at most 0.4% by weight of the composition.
- Useful weight% ranges of the cationic surfactant for inclusion in the composition of the invention are 0.01 to 0.5%, preferably 0.05 to 0.5%, and most preferably 0.1 to 0.4% by weight of the composition. It is observed that using concentrations of the cationic surfactant higher than the claimed range adversely affects the viability of the bacterial spores which are included in the composition of the invention
- the composition of the invention includes a combination of bacterial spores which is selected from a combination of Bacillus amyloliquefaciens, Bacillus megaterium, and Bacillus subtilis and one or both of Bacillus pumilus and Bacillus thuringiensis.
- a combination of bacterial spores as per this invention, is meant that the spores of the bacteria may be included in the composition.
- a preferred aspect of the invention comprises a combination of bacterial spores which includes Bacillus amyloliquefaciens, Bacillus megaterium, Bacillus subtilis and Bacillus pumilus.
- a further preferred aspect of the invention comprises a combination of bacterial spores which includes Bacillus amyloliquefaciens, Bacillus megaterium, Bacillus subtilis, Bacillus pumilus and Bacillus thuringiensis.
- each of the bacterial spores are present in 1 to 70%, more preferably in 5 to 40% of the total number of the the bacterial spores.
- An even more preferred aspect of the invention relates to the bacterial spores Bacillus amyloliquefaciens, Bacillus megaterium, and Bacillus subtilis being included in 5 to 40% of the total number of the bacterial spores.
- An especially preferred aspect of the invention relates to the bacterial spores Bacillus pumilus and Bacillus thuringiensis each being included in 1 to 30%, preferably 5 to 20%, most preferably 5 to 15% of the total number of the bacterial spores.
- the combination of bacterial spores is included in 0.00005 to 1%, preferably 0.0001 to 1 %, more preferably 0.0005 to 1 %, further more preferably 0.005 to 1% by weight of the composition.
- the bacterial spores for inclusion in the composition of the invention can be in powder form having a count of around 10 11 cfu/g, but there could be other methods of growing and introducing the spores in the composition which are well known to a person skilled in the art.
- composition of the invention is preferably applied through use of diluents.
- Most preferred diluent is an aqueous base which preferably comprises 1 to 99% water. It is particularly prefererd that the pH of the composition is in the range of 5 to 7, preferably in the range of 5 to 6.
- composition of the invention may be formulated as a general purpose cleaner which is usually used to clean floors (in which case it may be known as a floor cleaner) or used to clean toilets (in which case it may be known as a toilet cleaner). It may also be used to clean other hard surfaces like furniture, table tops, kitchen platforms and other surfaces in homes, offices, restaurants and other public places.
- composition of the invention delivered as general purpose cleaner may further comprise a nonionic surfactant.
- a nonionic surfactant typically these can be included for the purpose of stabilising the compositions.
- Suitable nonionic surfactants include addition products of ethylene oxide and/or propylene oxide with fatty alcohols, fatty acids and fatty amines.
- the nonionic surfactant has an HLB of from about 7 to about 20, more preferably from 10 to 18, e.g. 12 to 16.
- GenapolTM C200 (Clariant) based on coco chain and 20 EG groups is an example of a suitable nonionic surfactant.
- the nonionic surfactant is present in an amount from 0.05 to 20%, more preferably 0.1 to 15 % based on the total weight of the composition.
- Ingredients like amphoteric surfactant and sequestrant may be included in the floor cleaner and toilet cleaner composition of the present invention.
- General purpose cleaners and toilet cleaners may be diluted before use. When diluted, they may be diluted with water in a weight ratio in the range of 1 :10 to 1 :1000.
- the general purpose or toilet cleaners are usually delivered in liquid, gel, foam or cream format.
- composition of the invention may also be delivered to provide the benefits of the invention to clothes or fabric that are laundered. It is preferably delivered through a fabric conditioning composition which additionally comprises 1 to 50% of a fabric softening active. Delivery through a fabric conditioning composition is preferred since it is included in the rinse stage (preferably the last rinse stage) of the laundering process. At this stage the fabric softening active ensures high levels of deposition of the bacteria on the fabric thereby ensuring long lasting hygiene benefit.
- the fabric conditioner composition is also referred to as a fabric softener.
- Fabric conditioners comprise active materials which soften or condition fabric.
- suitable fabric softening actives include: quaternary ammonium compounds, silicone polymers, polysaccharides, clays, amines, fatty esters, dispersible polyolefins, polymer latexes and mixtures thereof.
- the fabric softening active is preferably selected from a quaternary ammonium compound, or silicone polymer and mixtures thereof, more preferably a quaternary ammonium compound.
- the fabric softening compounds may preferably be cationic or non-ionic.
- the fabric softening compounds of the present invention are cationic.
- Fabric conditioning compositions for use in accordance with the invention may be dilute or concentrated.
- Dilute products typically contain up to about 6 wt.% of the composition softening compounds, generally about 1 to 5 wt.%
- concentrated products may contain up to about 50 wt. % of the composition softening compounds, preferably from about 5 to about 50 wt.%, more preferably from 6 to 25 wt.%.
- the products of the invention may contain from 1 to 50 wt. %, preferably from 2 to 25 wt. % of the composition softening compounds, more preferably 2 to 20 wt. % of softening compounds.
- the preferred softening compounds for use in fabric conditioner compositions of the invention are quaternary ammonium compounds (QAC).
- the QAC preferably comprises at least one chain derived from fatty acids, more preferably at least two chains derived from a fatty acids.
- fatty acids are defined as aliphatic monocarboxylic acids having a chain of 4 to 28 carbons.
- the fatty acid chains are palm or tallow fatty acids.
- the fatty acid chains of the QAC comprise from 10 to 50 wt. % of saturated C18 chains and from 5 to 40 wt. % of monounsaturated C18 chains by weight of total fatty acid chains.
- the fatty acid chains of the QAC comprise from 20 to 40 wt. %, preferably from 25 to 35 wt. % of saturated C18 chains and from 10 to 35 wt. %, preferably from 15 to 30 wt. % of monounsaturated C18 chains, by weight of total fatty acid chains.
- the preferred quaternary ammonium fabric softening compounds for use in compositions of the present invention are so called "ester quats".
- Particularly preferred materials are the ester-linked triethanolamine (TEA) quaternary ammonium compounds comprising a mixture of mono-, di- and tri-ester linked components.
- TAA ester-linked triethanolamine
- composition of the invention delivered as fabric conditioning composition may further comprise a nonionic surfactant. Typically these can be included for the purpose of stabilising the compositions. Suitable nonionic surfactants are those described above as suitable for use in general purpose or toilet cleaning compositions. If present, the nonionic surfactant is present in an amount from 0.01 to 10 wt.%, more preferably 0.1 to 5 wt.%, based on the total weight of the composition.
- the fabric conditioning composition of the invention preferably comprises 0.1 to 5 wt% of a non-ionic surfactant preferably an fatty alcohol ethoxylate.
- Co-softeners may be used in the fabric conditioning composition. When employed, they are typically present at from 0.1 to 20 wt.% and particularly at from 0.5 to 10 wt.%, based on the total weight of the composition.
- Preferred co-softeners include fatty esters, and fatty N-oxides.
- Fatty esters that may be employed include fatty monoesters, such as glycerol monostearate, fatty sugar esters, such as those disclosed WO 01/46361 (Unilever).
- compositions of the present invention may comprise a fatty complexing agent.
- suitable fatty complexing agents include fatty alcohols and fatty acids. Of these, fatty alcohols are most preferred.
- the composition of the present invention comprises 0.5 to 20 wt.% perfume materials by weight of the composition, more preferably 1 to 15 wt.% perfume materials, most preferably 2 to 10 wt. % perfume materials.
- the fabric conditioner composition is preferably in an aqueous form.
- the compositions preferably comprise from 75 to 95 wt.% water
- the fabric conditioning composition may be used to treat fabrics either in a hand washing or a machine washing process.
- the fabric conditioner is used in the rinse stage of the washing process.
- the clothes are treated with a 10 to 100 ml dose of fabric conditioner for a 4 to 7 kg load of clothes. More preferably, 10 to 80 ml for a 4 to 7 kg load of clothes.
- the composition of the invention may also be delivered as a rim block.
- a rim block is meant a shaped solid composition that is hung on to the rim of the toilet usually in a plastic cage like container so that every time the toilet is flushed, a quantity of water passes over the solid composition, eroding a part thereof before flushing into the toilet bowl.
- the toilet rim block preferably additionally includes a perfume to provide a lingering pleasant odour after every toilet flush.
- the composition of the invention may be useful for upkeep of kitchen items e.g.. utensils and dishes which may be cleaned using a liquid dishwash compositions.
- the composition is also useful for cleaning and disinfecting filters in dishwashing machines.
- the various ingredients other than the essential ingredients claimed in the present invention which may be included are anionic surfactants, non-ionic surfactants, and hydrotropes. Additionally, other ingredients like amphoteric surfactants and organic acids, may be included.
- liquid dishwash composition further comprises water in an amount ranging from 5 to 99 wt%, more preferably from 15 to 80 wt%, further more preferably from 30 to 65 wt%, by weight of the composition.
- liquid dishwash composition further comprises one or more sequestrants which may be included in 0.1 to 5 w% by weight of the composition.
- a preferred sequestrant is a phosphonic acid or a salt thereof.
- the most preferred sequestrant is 1 -Hydroxyethylidene-1 ,1 - diphosphonic acid (HEDP). It is preferable that the sequestrant is added to the formulation in acid form.
- liquid dishwash composition further comprises an enzyme with or without a suitable enzyme stabilizer.
- viscosity of the composition may suitably range from about 200 to about 10,000 mPa.s at 25°C at a shear rate of 21 sec 1 .
- the liquid dishwash composition preferably has pH in the range from 2.0 to 8.0, more preferably from 3.5 to 7.0.
- the liquid dishwash composition may further comprise one or more polymers which may be included in 0.001 to 10 wt%, more preferably from 0.1 to 6 wt%, still further more preferably from 1 to 3 wt%.
- the composition may be used as is, i.e. neat, or it may be diluted before use.
- the extent of dilution is generally dependent on market choice. In some markets a more concentrated product is desired while in others a more dilute product is preferred.
- the composition is a liquid dishwash compositions it is typically diluted with water in a weight ratio in the range of 1 :1 to 1 :10.
- the liquid dishwash composition may optionally comprise ingredients, such as fragrance, colorant, foam boosting agents, and odor absorbing materials.
- the composition of the invention is substantially free of an antimicrobial agent other than the cationic surfactant.
- substantially free of an antimicrobial agent is meant that the agent is not intentionally included in the composition at a concentration to provide a functional benefit.
- an agent may at most be present in less than 0.1%, more preferably less than 0.05%, furthermore preferably present in less than 0.01% by weight of the composition, and ideally absent from the composition.
- the composition is substantially free of a bleach like an oxygen-based bleach or a chlorine-based bleach.
- Another aspect of the present method relates to a method of disrupting biofilm on a surface comprising the step of contacting the desired surface with a composition of the invention preferably diluted with water.
- Yet another aspect of the present invention relates to a method of removing stains on a surface comprising the step of contacting the desired surface preferably made of ceramic, with a composition of the invention preferably diluted with water.
- Examples A, 1-3 Effect of combination of bacterial spores on biofilm disruption:
- a suspension of Pseudomonas strain (PA-01) culture is prepared in media. 1ml of this suspension is pipetted into the multi-well plate. This plate is incubated for 48 hours for the development of biofilm. After the incubation time, choice of formulation (1 ml) is added onto the pre-formed biofilms. Plate is incubated again for 48-72 hours. After incubation period, each well is treated with crystal violet dye (0.1 %) and is washed with distilled water 3-4 times. Plate is dried for a few hours and observed for the intensity of violet stain. The biofilm is extracted by adding 0.1 ml of 30% acetic acid to the wells, transferred to microplates and the absorbance read at 550 nm. Water is used as blank. The percentage of biofilm disruption is calculated over the control.
- Bl Bacillus licheniformis
- Bp Bacillus pumilus
- Bt Bacillus thuringiensis
- spores included in the following amounts Ba, Bm, and Bs at 5 to 40%, and Bp and Bt at 5 to 15% of the total number of the bacterial spores included.
- Examples A, 3, 4 Experiments were conducted for understanding biofilm disruption better using various combination of bacterial spores. Several experiments on the following combination of bacterial spores as shown in Table - 2 below were conducted and the general observation on quantity and quality of biofilm disruption is summarized in the table.
- Table - 3A Storage in the presence of 0.1 % BKC. All spore count is in log scale. Initial spore count is 8 log.
- Table - 3B Storage in the presence of 0.5% BKC. All spore count is in log scale. Initial spore count is 8 log.
- Table - 3C Storage in the presence of 0.75% BKC. All spore count is in log scale. Initial spore count is 8 log.
- the data in the tables 3A to 3C above indicates that the spores are stable at a BKC concentration of up to 0.5 wt% while it is not viable above that concentration.
- Examples B,C, 5-7 Effect of various compositions on immediate hygiene and biofilm disruption: Various compositions as shown in Table -4 were prepared and immediate hygiene as described below was measured as well as the biofilm disruption. All the compositions comprised a mixture of bacterial spores as per example -3. In addition, a certain amount of cationic surfactant benzalkonium chloride was included at a concentration as shown in Table -4 . Additionally, a second surfactant was included at the concentration given in the table. The results are summarized in Table - 4:
- 1.0 ml of the interfering substance Bovine Serum albumin
- 1.0 ml of the test suspension of 1.5 x 10 7 cfu/ml to 5.0 x 10 7 cfu/ml was added to the starting culture inoculum.
- 8.0 ml of one of the product test solutions/formulation was added.
- a stopwatch was started at the beginning of the addition till the required contact time.
- the tube was mixed and placed in a temperature controlled water bath at 20 °C for the chosen contact time. Just before the end of contact time, it was mixed again.
- 1.0 ml sample of the test mixture was taken and transferred into a tube containing 9.0 ml neutralizer. It was mixed and placed in a water bath controlled at (20 ⁇ 1)°C. After a neutralization time of 5 min ⁇ 10 s, the sample was mixed and immediately 1.0 ml of the neutralized test mixture was taken (containing neutralizer, product test solution, interfering substance, and test suspension) in duplicate and inoculated using the pour plate or spread plate technique.
- Table - 4 The data in the table above indicates that compositions as per the invention (Examples 5 -7) provide both immediate hygiene as was as biofilm disruption while compositions outside the invention (Examples B and C) do not.
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Abstract
La présente invention concerne une composition qui est utilisée pour améliorer l'hygiène sur des surfaces, notamment la destruction immédiate de germes, sur une période de temps prolongée telle que mise en évidence par désintégration d'un biofilm. Ceci est obtenu par l'intermédiaire d'une nouvelle composition d'un tensioactif cationique et d'une combinaison de spores bactériennes.
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IN202221010898 | 2022-02-25 | ||
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EP22171267.2 | 2022-05-03 |
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
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US6165965A (en) | 1999-04-16 | 2000-12-26 | Spartan Chemical Company, Inc. | Aqueous disinfectant and hard surface cleaning composition and method of use |
WO2001046361A1 (fr) | 1999-12-22 | 2001-06-28 | Unilever Plc | Compositions d'assouplissement de tissu |
US6387874B1 (en) * | 2001-06-27 | 2002-05-14 | Spartan Chemical Company, Inc. | Cleaning composition containing an organic acid and a spore forming microbial composition |
US20080233093A1 (en) * | 2007-03-23 | 2008-09-25 | Novozymes Biologicals, Inc. | Preventing and Reducing Biofilm Formation and Planktonic Proliferation |
WO2020008053A1 (fr) * | 2018-07-06 | 2020-01-09 | Reckitt Benckiser Vanish B.V. | Composition |
WO2021243324A1 (fr) * | 2020-05-29 | 2021-12-02 | Novozymes A/S | Compositions de nettoyage microbiennes |
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- 2023-02-07 WO PCT/EP2023/052918 patent/WO2023161008A1/fr active Search and Examination
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6165965A (en) | 1999-04-16 | 2000-12-26 | Spartan Chemical Company, Inc. | Aqueous disinfectant and hard surface cleaning composition and method of use |
WO2001046361A1 (fr) | 1999-12-22 | 2001-06-28 | Unilever Plc | Compositions d'assouplissement de tissu |
US6387874B1 (en) * | 2001-06-27 | 2002-05-14 | Spartan Chemical Company, Inc. | Cleaning composition containing an organic acid and a spore forming microbial composition |
US20080233093A1 (en) * | 2007-03-23 | 2008-09-25 | Novozymes Biologicals, Inc. | Preventing and Reducing Biofilm Formation and Planktonic Proliferation |
WO2020008053A1 (fr) * | 2018-07-06 | 2020-01-09 | Reckitt Benckiser Vanish B.V. | Composition |
WO2021243324A1 (fr) * | 2020-05-29 | 2021-12-02 | Novozymes A/S | Compositions de nettoyage microbiennes |
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