WO2023158134A1 - 연속혈당측정 바이오센서용 글루코즈 확산 제어막 용액, 이를 포함하는 연속혈당측정 바이오센서용 글루코즈 확산 제어막 및 이를 포함하는 연속혈당측정용 바이오센서 - Google Patents

연속혈당측정 바이오센서용 글루코즈 확산 제어막 용액, 이를 포함하는 연속혈당측정 바이오센서용 글루코즈 확산 제어막 및 이를 포함하는 연속혈당측정용 바이오센서 Download PDF

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Publication number
WO2023158134A1
WO2023158134A1 PCT/KR2023/001456 KR2023001456W WO2023158134A1 WO 2023158134 A1 WO2023158134 A1 WO 2023158134A1 KR 2023001456 W KR2023001456 W KR 2023001456W WO 2023158134 A1 WO2023158134 A1 WO 2023158134A1
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WIPO (PCT)
Prior art keywords
glucose
diffusion control
biosensor
continuous blood
blood glucose
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Ceased
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PCT/KR2023/001456
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English (en)
French (fr)
Korean (ko)
Inventor
백재욱
유경완
오인돈
김근회
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SD Biosensor Inc
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SD Biosensor Inc
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Publication date
Application filed by SD Biosensor Inc filed Critical SD Biosensor Inc
Priority to EP23756547.8A priority Critical patent/EP4481002A4/en
Priority to CA3244172A priority patent/CA3244172A1/en
Priority to CN202380022083.1A priority patent/CN119365540A/zh
Priority to US18/838,531 priority patent/US20250152049A1/en
Priority to JP2024548711A priority patent/JP7753563B2/ja
Publication of WO2023158134A1 publication Critical patent/WO2023158134A1/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L75/00—Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
    • C08L75/04—Polyurethanes
    • C08L75/06—Polyurethanes from polyesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material

Definitions

  • blood glucose management through CGM was more effective when programs such as education training and follow-up were provided, helping to correct blood glucose patterns and improve glycated hemoglobin in glycemic patients.
  • the oxidoreductase usable in the present invention may be one or more selected from the group consisting of various dehydrogenases, oxidases, esterases, etc.
  • an enzyme having a target substance as a substrate may be selected and used.
  • the electrode it may include two types of electrodes, such as a working electrode and a counter electrode, or may include three types of electrodes, such as a working electrode, a counter electrode, and a reference electrode.
  • an enzyme solution including an enzyme that can oxidize and reduce glucose, a crosslinking agent, and an electron transfer mediator is applied to a substrate equipped with at least two, preferably two or three electrodes. It may be an electrochemical biosensor manufactured by coating and then drying.
  • the counter electrode also serves as the reference electrode
  • gold, platinum, silver, or silver/silver chloride electrodes can be used as the counter electrode, and the three-electrode including the reference electrode can be used.
  • a silver/silver chloride electrode may be used as a reference electrode and a carbon electrode may be used as a counter electrode.
  • the glucose sensing sensitivity can be selectively controlled by controlling the ratio of the hydrophobic material included in the glucose diffusion control film.
  • glucose diffusion control membrane solution prepared in Examples 1 to 3 3mL of the glucose diffusion control membrane solution prepared in Examples 1 to 3, the hydrophilic solution prepared in Preparation Example 1, and the hydrophobic solution prepared in Preparation Example 2 were each dispensed into a glass petri dish, and incubated at room temperature (25 ° C) for 24 hours.
  • Glucose diffusion control membranes were prepared by drying, and their initial weights were measured.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medical Informatics (AREA)
  • Optics & Photonics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
PCT/KR2023/001456 2022-02-16 2023-02-01 연속혈당측정 바이오센서용 글루코즈 확산 제어막 용액, 이를 포함하는 연속혈당측정 바이오센서용 글루코즈 확산 제어막 및 이를 포함하는 연속혈당측정용 바이오센서 Ceased WO2023158134A1 (ko)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP23756547.8A EP4481002A4 (en) 2022-02-16 2023-02-01 Glucose diffusion control layer solution for continuous glucose monitoring biosensor, glucose diffusion control layer for continuous glucose monitoring biosensor including it and continuous glucose monitoring biosensor including it
CA3244172A CA3244172A1 (en) 2022-02-16 2023-02-01 Glucose diffusion layer for continuous blood glucose-measuring biosensor
CN202380022083.1A CN119365540A (zh) 2022-02-16 2023-02-01 连续血糖测定生物传感器用葡萄糖扩散控制膜溶液、包含其的连续血糖测定生物传感器用葡萄糖扩散控制膜及包含其的连续血糖测定用生物传感器
US18/838,531 US20250152049A1 (en) 2022-02-16 2023-02-01 Glucose diffusion control layer solution for continuous blood glucose-measuring biosensor, glucose diffusion control layer for continuous blood glucose-measuring biosensor comprising same, and continuous blood glucose-measuring biosensor comprising same
JP2024548711A JP7753563B2 (ja) 2022-02-16 2023-02-01 連続血糖測定バイオセンサー用グルコース拡散制御膜溶液、これを含む連続血糖測定バイオセンサー用グルコース拡散制御膜およびこれを含む連続血糖測定用バイオセンサー

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KR10-2022-0020018 2022-02-16
KR1020220020018A KR102389269B1 (ko) 2022-02-16 2022-02-16 연속혈당측정 바이오센서용 글루코즈 확산 제어막 용액, 이를 포함하는 연속혈당측정 바이오센서용 글루코즈 확산 제어막 및 이를 포함하는 연속혈당측정용 바이오센서

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WO2023158134A1 true WO2023158134A1 (ko) 2023-08-24

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US (1) US20250152049A1 (cg-RX-API-DMAC7.html)
EP (1) EP4481002A4 (cg-RX-API-DMAC7.html)
JP (1) JP7753563B2 (cg-RX-API-DMAC7.html)
KR (1) KR102389269B1 (cg-RX-API-DMAC7.html)
CN (1) CN119365540A (cg-RX-API-DMAC7.html)
CA (1) CA3244172A1 (cg-RX-API-DMAC7.html)
WO (1) WO2023158134A1 (cg-RX-API-DMAC7.html)

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Publication number Priority date Publication date Assignee Title
KR102389269B1 (ko) * 2022-02-16 2022-04-21 네메시스 주식회사 연속혈당측정 바이오센서용 글루코즈 확산 제어막 용액, 이를 포함하는 연속혈당측정 바이오센서용 글루코즈 확산 제어막 및 이를 포함하는 연속혈당측정용 바이오센서
KR102790925B1 (ko) 2022-11-02 2025-04-07 재단법인 대구경북첨단의료산업진흥재단 향상된 젖음성을 가지는 적층체, 이를 포함하는 액체 시료 분석용 디바이스 및 이를 이용한 액체 시료 분석방법
EP4648680A2 (en) 2023-01-13 2025-11-19 Abbott Diabetes Care Inc. Biosensors with hydrophilic polyurethane membranes

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KR20210042686A (ko) * 2019-10-10 2021-04-20 주식회사 아이센스 바이오센서용 다기능성 고분자 코팅막 조성물 및 이를 포함하는 바이오센서
KR102389269B1 (ko) * 2022-02-16 2022-04-21 네메시스 주식회사 연속혈당측정 바이오센서용 글루코즈 확산 제어막 용액, 이를 포함하는 연속혈당측정 바이오센서용 글루코즈 확산 제어막 및 이를 포함하는 연속혈당측정용 바이오센서

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See also references of EP4481002A4

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JP2025508751A (ja) 2025-04-10
KR102389269B1 (ko) 2022-04-21
US20250152049A1 (en) 2025-05-15
EP4481002A4 (en) 2026-01-07
EP4481002A1 (en) 2024-12-25
CN119365540A (zh) 2025-01-24
JP7753563B2 (ja) 2025-10-14
CA3244172A1 (en) 2025-01-17

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