WO2023152727A1 - Composition dermatologique comprenant des protéines de soie et ses utilisations dans le domaine cosmétique et dans le traitement de maladies dermatologiques - Google Patents
Composition dermatologique comprenant des protéines de soie et ses utilisations dans le domaine cosmétique et dans le traitement de maladies dermatologiques Download PDFInfo
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- WO2023152727A1 WO2023152727A1 PCT/IB2023/051331 IB2023051331W WO2023152727A1 WO 2023152727 A1 WO2023152727 A1 WO 2023152727A1 IB 2023051331 W IB2023051331 W IB 2023051331W WO 2023152727 A1 WO2023152727 A1 WO 2023152727A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
Definitions
- the present invention relates to a dermatological composition and its uses in the cosmetic field and in the treatment of dermatological diseases.
- the skin is an organ having fundamental importance to the human organism, as it protects from the external environment, is responsible for each person’s aesthetic appearance and tactile sensations.
- the skin structure functions as an essential barrier to maintain skin hydration within physiological values.
- the main factors in this barrier that preside over the maintenance of hydration are: the stratum corneum, epidermal lipids, the Natural Moisturizing Factor (NMF) and the surface hydrolipidic film. These components undergo a continuous renewal process related to the ability of keratinocytes in the epidermis to continuously reproduce and differentiate, thus shaping the various layers that make up the epidermis.
- NMF Natural Moisturizing Factor
- the main factors of dehydration are of the chemical type (e.g., the solvent and delipidizing action related to the repeated application of surfactants) or related to unfavorable climatic and environmental conditions: wind, cold and humidity of environments, when intervening separately or jointly, cause dehydration of the stratum corneum with the formation of dry, rough, flaky, cracked skin, redness, itching and other irritative phenomena.
- dry skin can be caused by endogenous factors of hormonal, dietary and pharmacological origin.
- endogenous factors of a pharmacological origin The management of the adverse effects related to endogenous factors of a pharmacological origin, is considerably complicated since, the occurrence of skin disorders, often turns out to be a secondary aspect to the patient’s main clinical picture.
- compositions suitable for the treatment of dry, reddened and cracked skin that are alcohol-based but comprising additives of synthetic origin that do not meet the requirements of tolerability, safety and efficacy needed for the skin of oncology patients.
- compositions specifically formulated for the prevention and treatment of dermatitis caused by anti-cancer therapies such as chemotherapy and radiation therapy.
- the main aim of the present invention is to devise a dermatological composition that meets the requirements of tolerability, safety and efficacy needed for dry and cracked skin, particularly but not limited to oncology patients.
- Another object of the present invention is to devise a dermatological composition free of synthetic substances and entirely consisting of natural components.
- Another object of the present invention is to devise a dermatological composition which is easily applicable and rapidly absorbed.
- Another object of the present invention is to devise a dermatological composition which allows the aforementioned drawbacks of the prior art to be overcome within the framework of a simple, rational, easy and efficient to use as well as cost-effective solution.
- the present invention relates to a dermatological composition.
- the composition in accordance with the present invention comprises: water present in a concentration by weight, evaluated with respect to the total weight of the composition, greater than 30%; at least one hydrolyzed extract of silk proteins present in a concentration by weight, evaluated with respect to the total weight of the composition, greater than 15%; at least one antioxidant agent; at least one preservative agent present in a concentration by weight, evaluated with respect to the total weight of the composition, less than 5%.
- the hydrolyzed extract of silk proteins consists of a fibroin hydrolyzed extract.
- the fibroin hydrolyzed extract is present in a concentration by weight, evaluated with respect to the total weight of the composition, greater than 25%.
- thermal water refers to water obtained from thermal sources.
- Thermal water consists of thermal water comprising at least two of: calcium, magnesium, iron, manganese, silicon, copper and zinc.
- thermal water in accordance with the present invention comprises: calcium, magnesium, iron, manganese, silicon, copper and zinc.
- thermal water greatly increases the functional value of the invention, as the synergistic presence of the aforementioned elements allows the skin to be hydrated and purified, thus accelerating the healing processes thereof from dermatitis.
- the presence of silicon increases the antioxidant power of the composition in accordance with the present invention, thus stimulating cell regeneration.
- thermal water is present in a concentration by weight, evaluated with respect to the total weight of the composition, greater than 35%.
- the hydrolyzed extract comprises fibroin in a concentration by weight, evaluated with respect to the total weight of the extract, comprised between 2% and 15%.
- the hydrolyzed extract comprises fibroin in a concentration by weight, evaluated with respect to the total weight of the extract, comprised between 4% and 12%.
- fibroin in the composition in accordance with the present invention allows oxygen exchanges with the outside world, thus ensuring optimal skin homeostasis.
- a fibroin hydrolyzed extract allows sterilization of the composition in accordance with the present invention, thus preventing degradation of the components contained therein.
- a fibroin hydrolyzed extract allows the stimulation of collagen production and thus the reproduction of fibroblasts so it performs a regenerative activity on the skin, synergistically with antibacterial, antifungal and antiviral activity by attacking and destroying the membrane of the pathogenic microorganisms on the skin.
- a fibroin hydrolyzed extract fights against skin redness and erythema, performs a reparative function on scars and keloids, deeply moisturizing the tissues and allowing its use even in the presence of viral and herpetic infections.
- the antioxidant agent comprises tocopherols.
- the antioxidant agent is Vitamin E or, alternatively, tocopheryl acetate.
- the preservative agent comprises at least one of citric acid, benzyl alcohol, benzoic acid, capryloyl glycol, or mixtures thereof, present in a concentration by weight, evaluated with respect to the total weight of the composition, of less than 1%.
- composition according to the invention comprises at least one emollient agent selected from the list comprising: ethylhexyl palmitate, glycerin, ethylhexyl stearate, undecane, tridecane, ethylhexyl palmitate, caprylic/capric triglyceride, ethylhexylglycerin or mixtures thereof.
- emollient agent selected from the list comprising: ethylhexyl palmitate, glycerin, ethylhexyl stearate, undecane, tridecane, ethylhexyl palmitate, caprylic/capric triglyceride, ethylhexylglycerin or mixtures thereof.
- the at least one emollient agent is present in a concentration by weight, evaluated with respect to the total weight of the composition, of less than 8%.
- composition comprises at least one emulsifying agent selected from the list comprising: cetyl alcohol, cetylstearyl alcohol, glyceryl stearate citrate, shea butter or mixtures thereof.
- the composition comprises at least one thickening agent present in a concentration by weight, evaluated with respect to the total weight of the composition, of less than 3%.
- the at least one thickening agent comprises: xanthan gum, propylene glycol or mixtures thereof.
- composition according to the invention comprises at least one chelating agent present in a concentration by weight, evaluated with respect to the total weight of the composition, of less than 5%.
- the chelating agent comprises tetrasodium glutamate diacetate.
- composition comprises at least one antimicrobial agent comprising, in turn, at least one of: phenoxyethanol and lactic acid.
- composition in accordance with the present invention comprises at least one of freeze-dried annone pulp extract, beeswax, alba wax, turmeric essential oil, rice starch and vitamin A.
- the composition is in creamy form and comprises: freeze-dried annone extract, one of either beeswax or Alba wax, Turmeric essential oil and rice starch.
- freeze-dried annone extract has the following properties: anti- aging; antioxidant due to the presence of polyphenols having anti-cancer action; healing and cell regeneration; antiviral.
- freeze-dried annone extract comprises folic acid and vitamins C and B.
- beeswax or Alba wax has the following properties: hydrophobic and protective on the stratum corneum by preventing excessive water loss from the skin; emollient; emulsifier between water and oil; soothing to the skin; antibacterial.
- beeswax or Alba wax is present in a concentration by weight, evaluated with respect to the total weight of the composition, of less than 10%, preferably less than 5%.
- Turmeric essential oil has the following properties: preservative, antioxidant, sebum regulator, antibacterial, antiviral, antifungal, anti-cancer, anti-allergic and anti-aging.
- the rice starch powder has the following properties: refreshing, soothing and anti-itching.
- rice starch makes it possible to increase the density of the cream, acting as a natural thickener and avoiding the use of synthetic thickening agents.
- the composition is in liquid form and comprises vitamin A.
- both embodiments of the composition according to the invention comprise thermal water, fibroin hydrolyzed extract, vitamin E and citric acid.
- the dermatological composition in creamy form and that in liquid form differ from each other, the former, by the characteristic presence of annone pulp, beeswax or Alba wax, Turmeric essential oil and rice starch, while the latter by the presence of Vitamin A.
- composition in accordance with this invention fibroin hydrolysate: 20%. water: 50%-75%; fibroin hydrolysate: 20%; ethylhexyl palmitate: l%-5%; glycerin: 3%; ethylhexyl stearate: l%-5%; undecane and tridecane: 0.1 %- 1 %; caprylic/capric triglyceride: l%-5%; cetyl alcohol: l%-5%; cetylstearyl alcohol: l%-5%; glyceryl stearate citrate: l%-5%; shea butter: 1%; xanthan gum:0.1%-l%; benzyl alcohol, benzoic acid, caprylic glycol: 0.1%-1%; tetrasodium glutamate diacetate: 0.1 %- 1 % .
- EXAMPLE 1 dermatological composition in creamy form. thermal water: 35%; fibroin hydrolyzed extract titrated to 4%: 30%; freeze-dried annone pulp extract: 10%; beeswax or Alba wax 2.5%;
- Turmeric essential oil 10%;
- Vitamin E 6% rice starch: 6% citric acid: 0.5%.
- EXAMPLE 2 dermatological composition in liquid form. thermal water: 35%; fibroin hydrolyzed extract titrated to 6%: 40%; vitamin A: 15%; vitamin E: 9.2%; citric acid: 0.8%.
- the present invention relates to the use of the composition in the prevention and treatment of dermatitis caused by anti-cancer drugs.
- the present invention relates to the use of the composition in the cosmetic field.
- the present invention relates to a dermatological kit comprising the dermatological composition in creamy form and the dermatological composition in liquid form.
- compositions surprisingly allows the drawbacks of known compositions to be overcome, namely the unsuitability for the treatment of sensitive and dehydrated skin characteristic of patients undergoing cancer therapies.
- composition in accordance with the present invention gives high degree of hydration and oxygenation of the skin tissues that undergo biochemical and structural changes as a result of cancer therapies.
- composition according to the invention in creamy form has a particularly fluid texture compared to creams currently on the market, allowing it to be applied not only to the face but also to other areas such as, e.g., chest, legs, arms or back.
- composition according to the invention in liquid form has improved absorption, allowing its application even on sensitive skin altered by cancer treatments.
- this composition has a high antibacterial and antifungal activity since the tissues are subjected to not only environmental but also therapeutic stresses, the skin of oncology patients being characterized by altered vascularization, fragility and having an altered pH due to the homeostatic skin alteration caused by anti-cancer therapies.
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Abstract
Composition dermatologique comprenant : de l'eau présente à une concentration en poids, évaluée par rapport au poids total de la composition, supérieure à 30 % ; au moins un extrait hydrolysé de protéines de soie présent à une concentration en poids, évaluée par rapport au poids total de la composition, supérieure à 15 % ; au moins un agent antioxydant ; au moins un agent conservateur présent à une concentration en poids, évaluée par rapport au poids total de la composition, inférieure à 5 %. Ladite composition est destinée à être utilisée dans la prévention et le traitement de la dermatite provoquée par des médicaments anticancéreux.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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IT102022000002684A IT202200002684A1 (it) | 2022-02-14 | 2022-02-14 | Composizione dermatologica e suoi usi in campo cosmetico e nel trattamento di patologie dermatologiche |
IT102022000002684 | 2022-02-14 |
Publications (1)
Publication Number | Publication Date |
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WO2023152727A1 true WO2023152727A1 (fr) | 2023-08-17 |
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PCT/IB2023/051331 WO2023152727A1 (fr) | 2022-02-14 | 2023-02-14 | Composition dermatologique comprenant des protéines de soie et ses utilisations dans le domaine cosmétique et dans le traitement de maladies dermatologiques |
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IT (1) | IT202200002684A1 (fr) |
WO (1) | WO2023152727A1 (fr) |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001081021A (ja) * | 1999-09-09 | 2001-03-27 | Ichimaru Pharcos Co Ltd | 化粧料組成物 |
US20090042846A1 (en) * | 2005-08-19 | 2009-02-12 | Bioderm Research | Topical Delivery System for Phytosterols |
WO2013159101A1 (fr) * | 2012-04-20 | 2013-10-24 | Trustees Of Tufts College | Compositions de soins personnels à base de fibroïne de soie |
US20170216171A1 (en) * | 2006-02-10 | 2017-08-03 | Dupont Tate & Lyle Bio Products Company, Llc | Biodegradable compositions comprising renewably-based, biodegradable 1,3-propanediol |
US9732071B2 (en) * | 2015-10-01 | 2017-08-15 | Senomyx, Inc. | Compounds useful as modulators of TRPM8 |
CN107072916A (zh) * | 2014-11-10 | 2017-08-18 | 昭和电工株式会社 | 保湿剂 |
WO2021035087A1 (fr) * | 2019-08-20 | 2021-02-25 | Evolved By Nature, Inc. | Compositions de soins personnels à base de soie |
-
2022
- 2022-02-14 IT IT102022000002684A patent/IT202200002684A1/it unknown
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2023
- 2023-02-14 WO PCT/IB2023/051331 patent/WO2023152727A1/fr unknown
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JP2001081021A (ja) * | 1999-09-09 | 2001-03-27 | Ichimaru Pharcos Co Ltd | 化粧料組成物 |
US20090042846A1 (en) * | 2005-08-19 | 2009-02-12 | Bioderm Research | Topical Delivery System for Phytosterols |
US20170216171A1 (en) * | 2006-02-10 | 2017-08-03 | Dupont Tate & Lyle Bio Products Company, Llc | Biodegradable compositions comprising renewably-based, biodegradable 1,3-propanediol |
WO2013159101A1 (fr) * | 2012-04-20 | 2013-10-24 | Trustees Of Tufts College | Compositions de soins personnels à base de fibroïne de soie |
CN107072916A (zh) * | 2014-11-10 | 2017-08-18 | 昭和电工株式会社 | 保湿剂 |
US9732071B2 (en) * | 2015-10-01 | 2017-08-15 | Senomyx, Inc. | Compounds useful as modulators of TRPM8 |
WO2021035087A1 (fr) * | 2019-08-20 | 2021-02-25 | Evolved By Nature, Inc. | Compositions de soins personnels à base de soie |
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