Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
  • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
  • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
  • C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
  • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
  • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
  • C07C49/385—Saturated compounds containing a keto group being part of a ring
  • C07C49/395—Saturated compounds containing a keto group being part of a ring of a five-membered ring
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
  • C11B9/00—Essential oils; Perfumes
  • C11B9/0026—Essential oils; Perfumes compounds containing an alicyclic ring not condensed with another ring
  • C11B9/003—Essential oils; Perfumes compounds containing an alicyclic ring not condensed with another ring the ring containing less than six carbon atoms
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C2601/00—Systems containing only non-condensed rings
  • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
  • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Definitions

• the present invention relates to a bio-based methyl dihydrojasmonate, a bio-based cyclopentanone, a process for their preparation and use thereof.
• Methyl dihydrojasmonate (CAS 24851-98-7) is an aroma compound whose odor is floral and citrus in racemic mixtures. The compound is used in perfumery and in the food industry. Methyl dihydrojasmonate is utilized as synthetic equivalent to methyl jasmonate, a component of naturally occurring jasmine. Industrially, methyl dihydrojasmonate may be produced from adipic acid as precursor for the preparation of cyclopentanone. Cyclopentanone can then be functionalized by aldol condensation with pentanal followed by a Michael addition of dimethyl malonate.
• Synthetic flavourings tend to be less well liked by consumers than flavourings of natural origin. There is thus a growing interest in other sources of methyl dihydrojasmonate and in particular routes using natural raw material that can be labelled either natural or bio-sourced according to existing legislations.
• the present invention relates to methyl dihydrojasmonate having a bio-based carbon content higher or equal to 30%, or wherein the number of carbon atoms from bio-based origin is higher or equal to 5.
• the present invention relates to a process for the preparation of methyl dihydrojasmonate from bio-based furfuryl alcohol whose bio-based carbon content is higher or equal to 50%.
• the present invention further relates to a bio-based cyclopentanone having a bio-based carbon content higher or equal to 50%.
• the present invention relates to a bio-based cyclopentanone having at least 2 bio-based carbon atoms.
• the present invention relates to a process for the preparation of cyclopentanone from bio-based furfuryl alcohol whose bio-based carbon content is higher or equal to 50%.
• the present invention further refers to the use of a cyclopentanone or a methyl dihydrojasmonate according to the present invention as flavor or fragrance, in particular its use in perfumery, cosmetics, pharmacy.
• the invention also relates to a composition
• a composition comprising a methyl dihydrojasmonate and/or cyclopentanone according to the invention, preferably selected from the group consisting of food products, beverages, cosmetic formulations, pharmaceutical formulations, fragrances.
• any particular upper limit can be associated with any particular lower limit.
• bio-based material designate a product that is composed, in whole or in significant part, of biological products or renewable agricultural materials (including plant, animal, and marine materials) or forestry materials.
• bio-based carbon refers to carbon of renewable origin like agricultural, plant, animal, fungi, microorganisms, marine, or forestry materials living in a natural environment in equilibrium with the atmosphere.
• the bio-based carbon content is typically evaluated by the means of the carbon- 14 dating (also referred to as carbon dating or radiocarbon dating).
• carbon dating or radiocarbon dating also referred to as carbon dating or radiocarbon dating.
• bio-based carbon content refers to the molar ratio of bio-based carbon to the total carbon of the compound or the product.
• the bio-based carbon content can preferably be measured by a method consisting in measuring decay process of 14C (carbon- 14), in disintegrations per minute per gram carbon (or dpm/gC), through liquid scintillation counting, preferably according to the Standard Test Method ASTM D6866-16.
• ASTM D6866 is said to be equivalent to the ISO standard 16620-2.
• the testing method may preferably utilize AMS (Accelerator Mass Spectrometry) along with IRMS (Isotope Ratio Mass Spectrometry) techniques to quantify the bio-based content of a given product.
• the expression “5 13 C” refers to the mean isotopic deviation of carbon- 13.
• the mean isotopic deviation of 13C is measured by Isotope Ratio Mass Spectrometry using PDB as international standard.
• the isotopic fingerprint of a compound provides information on the origin of said compound in particular natural or fossil.
• the invention relates to methyl dihydroj asmonate having a bio-based carbon content higher or equal to 30%, preferably higher or equal to 35%, more preferably higher or equal to 38%.
• methyl dihydroj asmonate according to the present invention has a bio-based carbon content lower or equal to 105%, preferably equal to lower to 100%, more preferably lower than 100%.
• the number of carbon atoms from bio-based origin of methyl dihydroj asmonate according to the present invention is higher or equal to 2, preferably higher or equal to 5, more preferably higher or equal to 7.
• all carbon atoms of methyl dihydroj asmonate according to the present invention are from bio-based origin.
• the present invention further relates to a composition
• a composition comprising, or consisting essentially of methyl dihydroj asmonate, whose bio-based carbon content is higher or equal to 30%, preferably higher or equal to 35%, more preferably higher or equal to 38.
• Said methyl dihydroj asmonate may represent the major compound of the composition according to the present invention. Accordingly said methyl dihydroj asmonate may represent more than 50%, preferably more than 70%, more preferably more than 80% regarding the total weight of the composition. In a more preferred aspect of the present invention the said methyl dihydroj asmonate may represent more than 90%, preferably more than 95%, more preferably more than 96%, more preferably more than 99%, most preferably more than 99.5% regarding the total weight of the composition.
• the impurity may represent from 1 ppm to 5000 ppm, preferably from 1 ppm to 500 ppm, more preferably from 1 ppm to 50 ppm, most preferably from 1 ppm to 20 ppm, regarding the total weight of the composition.
• the impurity may represent from 1 ppm to 100 ppm, preferably from 1 ppm to 50 ppm, and more preferably from 1 ppm to 10 ppm regarding the total weight of methyl dihydroj asmonate.
• the methyl dihydroj asmonate of the present invention has a purity higher than 90%, preferably higher than 95%, more preferably higher than 96%, even more preferably higher than 99%, even more preferably higher than 99.5%, most preferably higher than 99.9%. It is well-known by the person skilled in the art that the organoleptic properties of a flavoring substance may depend from the presence and the quantity of some impurities. That is why the manufacturing method is critical for the flavor of the final compound.
• the methyl dihydrojasmonate of the present invention displays satisfactory organoleptic properties.
• the organoleptic profile of the methyl dihydrojasmonate of the present invention is equivalent to the organoleptic profile of methyl dihydrojasmonate from fossil origin in particular synthetically prepared from adipic acid, cyclopentene or dicylopentadiene.
• the invention relates to cyclopentanone having a bio-based carbon content higher or equal to 50%, preferably higher or equal to 70%.
• cyclopentanone according to the present invention has a bio-based carbon content lower or equal to 105%, preferably equal to lower to 100%, more preferably lower than 100%.
• the number of carbon atoms from bio-based origin of cyclopentanone according to the present invention is higher or equal to 2, preferably higher or equal to 3, more preferably higher or equal to 4.
• all carbon atoms of cyclopentanone according to the present invention are from bio-based origin.
• the present invention further relates to a composition
• a composition comprising, or consisting essentially of cyclopentanone, whose bio-based carbon content is higher or equal to 50%, preferably higher or equal to 70%.
• the bio-based cyclopentanone of the present invention may preferably display a mean isotopic 13 C deviation of from -25 to -8%o, preferably from -24 %o to -9%o, more preferably from -15%o to -9%o.
• Said cyclopentanone may represent the major compound of the composition according to the present invention. Accordingly said cyclopentanone may represent more than 50%, preferably more than 70%, more preferably more than 80% regarding the total weight of the composition. In a more preferred aspect of the present invention the said cyclopentanone may represent more than 90%, preferably more than 95%, more preferably more than 96%, more preferably more than 99%, most preferably more than 99.5% regarding the total weight of the composition.
• the impurity may represent from 1 ppm to 5000 ppm, preferably from 1 ppm to 500 ppm, more preferably from 1 ppm to 50 ppm, most preferably from 1 ppm to 20 ppm, regarding the total weight of the composition.
• the impurity may represent from 1 ppm to 100 ppm, preferably from 1 ppm to 50 ppm, and more preferably from 1 ppm to 10 ppm regarding the total weight of cyclopentanone.
• the cyclopentanone of the present invention has a purity higher than 90%, preferably higher than 95%, more preferably higher than 96%, even more preferably higher than 99%, even more preferably higher than 99.5%, most preferably higher than 99.9%.
• the cyclopentanone has a purity comprised between 90% and 99.5% and comprises at least one compound selected from cyclopentanol and tetrahydrofurfuryl alcohol.
• the invention further relates to a composition
• a composition comprising:
• the composition of the present invention comprises cyclopentanone wherein the cyclopentanone has a bio-based carbon content higher or equal to 50% or wherein the number of carbon atoms from bio-based origin is higher or equal to 2.
• the composition of the present invention comprises cyclopentanone wherein the cyclopentanone has a bio-based carbon content higher or equal to 70%, and/or wherein the number of carbon atoms from bio-based origin is higher or equal to 3, preferably higher or equal to 4.
• the composition of the present invention comprises cyclopentanone wherein the cyclopentanone displays a mean isotopic 13 C deviation of from -25 to -8%o, more preferably from -24 to -9%o, more preferably from -15%o to -9%o.
• the organoleptic properties of a flavoring substance may depend from the presence and the quantity of some impurities. That is why the manufacturing method is critical for the flavor of the final compound.
• the cyclopentanone of the present invention displays satisfactory properties in particular for its use in the preparation flavor and/or fragrances, in particular methyl dihydrojasmonate and for its use in electronics, in particular as a solvent for the manufacturing of semiconductors.
• the present invention relates to a process for the preparation of a methyl dihydrojasmonate and/or a cyclopentanone and/or a composition according to the present invention from furfuryl alcohol whose bio-based carbon content is higher or equal to 50%.
• the furfuryl alcohol used for the preparation of the methyl dihydrojasmonate and/or a cyclopentanone according to the present invention is a bio-based furfuryl alcohol.
• Bio-based furfuryl alcohol having a bio-based carbon content above 50% is hereafter also called “bio-based furfuryl alcohol”.
• Bio-based furfuryl alcohol according to the invention may have a bio-based carbon content above 70%, preferably above 85%, more preferably above 90%, more preferably above 95%, more preferably above 98%, and more preferably above 99%.
• Bio-based furfuryl alcohol is a commercial product.
• the bio-based furfuryl alcohol according to the invention may have a bio-based carbon content lower or equal to 105%, preferably lower or equal to 103%, more preferably lower or equal to 100%.
• the raw furfuryl alcohol may contain some impurities. Said impurities may be specific to the origin of the compound.
• the content of each impurity in the bio-based furfuryl alcohol may be comprised between 0.005 and 0.1%, more preferably between 0.01 and 0.08%.
• furfural may be obtained from wood hemicellulose by degradation into xylose and then dehydration of xylose into furfural.
• Current commercial processes are usually starting from wood or biomass wastes like com stovers.
• the raw furfural may contain some impurities. Said impurities may be specific to the origin of the compound.
• the content of each impurity in the bio-based furfural may be comprised between 0.005 and 0.1%, more preferably between 0.01 and 0.08%.
• the bio-based furfuryl alcohol used in the present invention may preferably display a mean isotopic 13 C deviation of from -25 to -12%o, more preferably from -24 to -14%o.
• the bio-based furfuryl alcohol used in the present invention may display a mean isotopic deviation of from -15%o to -8%o, preferably from -13%o to -9%o.
• Pentanal may be bio-based pentanal or non-bio-based pentanal.
• bio-based pentanal has a bio-based carbon content above 50% is hereafter also called “bio-based pentanal”.
• Bio-based pentanal according to the invention may have a bio-based carbon content above 60%, preferably between 75% and 105%, more preferably between 90% and 103%, more preferably between 95% and 100%, more preferably between 98% and 100%, and more preferably between 99% and 100%.
• the pentanal may be from fossil origin. According to a particular embodiment, the pentanal may be upcycled, for example the pentanal may be obtained from wastes or by-products of plastic production.
• the raw pentanal may contain some impurities. Said impurities may be specific to the origin of the compound. Typically, the content of each impurity in the biobased pentanal may be comprised between 0.005 and 0.1%, more preferably between 0.01 and 0.08%.
• Dimethyl malonate may be bio-based dimethyl malonate or non-bio-based dimethyl malonate.
• dimethyl malonate has a bio-based carbon content above 50% is hereafter also called “bio-based dimethyl malonate”.
• Bio-based dimethyl malonate according to the invention may have a bio-based carbon content above 60%, preferably between 75% and 105%, more preferably between 90% and 103%, more preferably between 95% and 100%, more preferably between 98% and 100%, and more preferably between 99% and 100%.
• Dimethyl malonate may be obtained from malonic acid, preferably malonic acid displays a mean isotopic 13 C deviation of from -22 to -17%o.
• the bio-based dimethyl malonate may be obtained by fermentation of glucose to produce malonic acid, see for example WO 2021/042058, followed by esterification with methanol, preferably biobased methanol.
• the process for the preparation of cyclopentanone or a composition of the present invention comprises: a step (a) wherein bio-based furfuryl alcohol is hydrogenated.
• the process for the preparation of methyl dihydrojasmonate comprises: a step (a) wherein bio-based furfuryl alcohol is hydrogenated.
• step (a) a bio-based cyclopentanone or composition comprising bio-based cyclopentanone is obtained.
• Step (a) is a hydrogenation step.
• Step (a) may be conducted according to the conditions described in Appl. Catal. B: Environ. 2014, 154-155, 294.
• Step (a) may give rise to some impurities, namely cyclopentanol and/or tetrahydrofurfuryl alcohol.
• Step (a) is generally conducted in aqueous solvent, preferably step (a) is conducted in water.
• the aqueous solvent may be a mixture of water and a water soluble organic solvent, preferably selected from alcohol, ethyl acetate, more preferably selected from the group consisting of ethanol, isopropanol, and ethyl acetate.
• step (a) is conducted at a pH comprised between 2 and 6, preferably comprised between 3 and 5.
• step (a) is conducted under an H2 atmosphere, preferably at a pressure comprised between 5 and 50 bar, more preferably comprised between 10 and 40 bar, still more preferably comprised between 20 and 30 bar.
• step (a) is conducted at a temperature comprised between 120°C and 200°C, preferably at a temperature comprised between 150°C and 180°C.
• the hydrogenation reaction (step (a)) is generally catalysed, preferably the catalyst is a metal catalyst, wherein the metal is preferably selected from Cu, Pd, Pt, Ni, Au, Rh, Ru.
• the catalyst may preferably be a nickel based catalyst, preferably Raney-nickel.
• the amount of catalyst is lower or equal to 20 wt%, preferably lower or equal to 10 wt%, still more preferably lower or equal to 1 wt%. Generally the amount of catalyst is higher or equal to 0.001 wt%, preferably lower or equal to 0.01 wt%, still more preferably lower or equal to 0.1 wt%.
• the furfuryl alcohol is hydrogenated to form a compound of formula (I) which is then hydrolysed to form a compound of formula (II).
• the compound of formula (II) is then under the same reaction condition hydrogenated to form cyclopentanone. This one-pot process is shown in the scheme below:
• the bio-based cyclopentanone obtained may be separated from the reaction mixture via standard separation techniques.
• an aqueous composition comprising: from 1 % to 10 % by weight, preferably from 1.5% to 5%, more preferably from 2% to 4% of cyclopentanone, from 0.01% to 1% by weight, preferably from 0.05% to 0.5% of cyclopentanol, and from 0.001% to 0.5% by weight, preferably from 0.01% to 0.1% of tetrahydrofurfuryl alcohol.
• the composition obtained after step (a) may be purified by azeotropic distillation of a composition comprising water, cyclopentanone and cyclopentanol.
• the distilled azeotrope is then further purified by decantation.
• the organic phase is then further distiller in order to obtain a purified cyclopentanone.
• the distillation may be performed at atmospheric pressure or under reduced pressure, preferably the distillation is performed under reduced pressure.
• reduce pressure prevents degradation of the cyclopentanone.
• the reaction mixture obtained after the hydrogenation step (a) may be used in its existing form, for example in step (b).
• the process for the preparation of methyl dihydrojasmonate further comprises: a step (b) wherein bio-based cyclopentanone is reacted with pentanal.
• step (b) is conducted after step (a).
• the pentanal may be a bio-based pentanal or a pentanal of fossil origin, for example upcycled.
• the pentanal may be obtained from a fatty acid, for example mystiric acid or lauric acid.
• Step (b) is an aldol condensation. Step (b) may be conducted according to the conditions described in US 4260830 or US 3158644.
• Step (b) is generally conducted in the presence of a base, preferably NaOH.
• the amount of pentanal is generally comprised between 0.5 and 1.2 equivalents.
• Step (b) is generally conducted in water.
• Step (b) may be conducted at ambient temperature.
• the compound of formula (III) may have a bio-based carbon content higher or equal to 50%, preferably higher or equal to 70%.
• the compound of formula (III) according to the present invention has a bio-based carbon content lower or equal to 105%, preferably equal to lower to 100%, more preferably lower than 100%.
• the number of carbon atoms from bio-based origin of the compound of formula (III) according to the present invention is higher or equal to 2, preferably higher or equal to 3, more preferably higher or equal to 4, preferably higher or equal to 5.
• all carbon atoms of the compound of formula (III) according to the present invention are from bio-based origin.
• the process for the preparation of methyl dihydrojasmonate further comprises: a step (c) wherein the compound of formula (III) is reacted with dimethyl malonate.
• step (c) is conducted after step (b), preferably conducted after step (a) and (b).
• the dimethyl malonate may be a bio-based dimethyl malonate or a dimethyl malonate of fossil origin.
• the bio-based dimethyl malonate may be obtained by fermentation of glucose, see for example WO 2021/042058, followed by esterification with bio-based methanol.
• Step (c) is a Michael addition. Step (c) may be conducted according to the conditions described in US 4260830.
• Step (c) is generally conducted in the presence of a base, preferably NaOH.
• the amount of dimethyl malonate is generally comprised between 1.0 and 1.5 equivalents.
• Step (c) is generally conducted in a solvent comprising an alcohol, preferably methanol.
• Step (c) may be conducted at a temperature comprised between -10°C and ambient temperature. After decarboxylation, methyl dihydrojasmonate is obtained.
• the methyl dihydrojasmonate obtained may have a bio-based carbon content higher or equal to 30%, preferably higher or equal to 35%, more preferably higher or equal to 38%.
• the methyl dihydrojasmonate according to the present invention has a bio-based carbon content lower or equal to 105%, preferably equal to lower to 100%, more preferably lower than 100%.
• the number of carbon atoms from bio -based origin of the methyl dihydrojasmonate according to the present invention is higher or equal to 2, preferably higher or equal to 3, more preferably higher or equal to 4, preferably higher or equal to 5.
• all carbon atoms of methyl dihydrojasmonate according to the present invention are from bio-based origin.
• the methyl dihydrojasmonate and/or cyclopentanone and/or composition obtainable by the process as disclosed above is a subject-matter of the present invention.
• These compounds differ from the compounds already known in the art by the fact that they are partly or wholly prepared from raw materials originating from natural or renewable sources.
• This specificity of the methyl dihydrojasmonate and/or cyclopentanone and/or composition can be determined by a bio-based carbon content measure and/or a mean isotopic 13 C deviation.
• the methyl dihydrojasmonate and/or cyclopentanone and/or composition of the present invention may advantageously be used as a flavour or a fragrance or as a solvent for the manufacture of semiconductors.
• the methyl dihydrojasmonate and/or cyclopentanone and/or composition of the present invention may be used in industry, for instance in the food, pharmaceutical or cosmetics industry, in particular for example for manufacturing fragrances.
• Another object of the present invention relates to a composition
• a composition comprising a methyl dihydrojasmonate and/or cyclopentanone and/or composition of the present invention preferably selected from the group consisting of food products, beverages, cosmetic formulations, pharmaceutical formulations and fragrances.
• Bio-based furfuryl alcohol (100% of bio-based carbon content) was hydrogenated in 60 mb water in the presence of a nickel catalyst (30 mg).
• the hydrogen pressure is of 30 bar and the temperature of 160°C.
• Example 2 Preparation of bio-based methyl dihydrojasmonate.
• Bio-based cyclopentanone (100% bio-based carbon content) of example 1 is reacted with pentanal to produce a compound of formula (III).
• the compound of formula (III) is then reacted with 100% bio-based dimethyl malonate having a bio-based carbon content of 100%.
• Methyl dihydrojasmonate is obtained and displays a bio-based carbon content of 62%.

Landscapes

• Chemical & Material Sciences (AREA)
• Organic Chemistry (AREA)
• Life Sciences & Earth Sciences (AREA)
• Engineering & Computer Science (AREA)
• Polymers & Plastics (AREA)
• Wood Science & Technology (AREA)
• Health & Medical Sciences (AREA)
• Food Science & Technology (AREA)
• Mycology (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Oil, Petroleum & Natural Gas (AREA)
• Nutrition Science (AREA)
• Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
• Seasonings (AREA)
• Medicinal Preparation (AREA)
• Cosmetics (AREA)
• Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
• Fats And Perfumes (AREA)

Priority Applications (4)

Applications Claiming Priority (2)

Publications (1)

Family

ID=85158660

Family Applications (1)

Country Status (5)

Citations (9)

• 2023
  • 2023-01-31 CN CN202380027070.3A patent/CN118871415A/zh active Pending
  • 2023-01-31 EP EP23703007.7A patent/EP4472943A1/en active Pending
  • 2023-01-31 US US18/833,783 patent/US20240383839A1/en active Pending
  • 2023-01-31 WO PCT/EP2023/052268 patent/WO2023144408A1/en not_active Ceased
  • 2023-01-31 JP JP2024544944A patent/JP2025503257A/ja active Pending

Patent Citations (9)

Non-Patent Citations (12)

Also Published As

Similar Documents

Legal Events