WO2023142534A1 - 程控设备和植入式神经刺激系统 - Google Patents

程控设备和植入式神经刺激系统 Download PDF

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Publication number
WO2023142534A1
WO2023142534A1 PCT/CN2022/125083 CN2022125083W WO2023142534A1 WO 2023142534 A1 WO2023142534 A1 WO 2023142534A1 CN 2022125083 W CN2022125083 W CN 2022125083W WO 2023142534 A1 WO2023142534 A1 WO 2023142534A1
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WIPO (PCT)
Prior art keywords
program
sliding
timing information
stimulation
target
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PCT/CN2022/125083
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English (en)
French (fr)
Inventor
马艳
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苏州景昱医疗器械有限公司
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Publication of WO2023142534A1 publication Critical patent/WO2023142534A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation

Definitions

  • the present application relates to the technical field of implantable medical devices, in particular to a program-controlled device and an implanted nerve stimulation system.
  • the implantable neurostimulation system mainly includes a stimulator implanted in the body and a program-controlled device outside the body.
  • Neuromodulation technology mainly uses stereotaxic surgery to implant electrodes in specific structures (i.e., target points) in the body, and the stimulator implanted in the patient sends electrical pulses to the target points through the electrodes to regulate the electrical activity of the corresponding neural structures and networks. Its function can improve symptoms and relieve pain.
  • the existing program-controlled equipment is not humane enough in terms of timing stimulation.
  • the stimulation time corresponding to the stimulation program is set by the manufacturer and cannot be adjusted. For example: 8:00 am to 8:00 pm corresponds to a stimulation program with a larger stimulus pulse amplitude, and automatically switches to a stimulation program with a smaller stimulus pulse amplitude for the rest of the time.
  • the defect of this program-controlled device is that the user cannot independently set the stimulation time corresponding to the stimulation program, cannot meet the different stimulation needs of different patients, is inflexible in use, and has poor user experience.
  • the purpose of this application is to provide a program-controlled device and an implanted nerve stimulation system to meet the different stimulation needs of different patients, with a wide range of applications and better user experience.
  • the present application provides a program-controlled device, which is applied to an implantable nerve stimulation system, and the implantable nerve stimulation system includes the program-controlled device arranged outside the patient's body and the stimulation device implanted in the patient's body. device;
  • the programmed device is communicatively connected to the stimulator, the programmed device comprising a controller;
  • the controller is configured to:
  • the touch screen Utilize the touch screen to receive a sliding operation, and in response to the sliding operation, obtain the timing information of the stimulation program, the stimulation program is used to indicate the identification and parameter value of the stimulation parameter of the stimulator, and the timing information is used to indicate the start time and end time;
  • control instructions are generated and sent to the stimulator, so that the stimulator generates electrical stimulation according to the control instructions and applies the electrical stimulation to the target tissue of the patient.
  • the beneficial effects of this technical solution are: on the one hand, the user can flexibly set the timing information corresponding to the stimulation program. Compared with the program-controlled equipment whose timing information cannot be adjusted, the program-controlled equipment of the present application can meet the different stimulation needs of different patients. Wide, user experience is better; on the other hand, users can set the timing information through sliding operation, compared with the method of step-by-step adjustment through button operation and the method of directly inputting specific values, the user's operation steps are greatly reduced, making the timing information The settings are faster and more convenient, further improving the user experience.
  • the controller is configured to obtain timing information of the stimulation program in the following manner:
  • the target programming mode is used to indicate at least one of the stimulation programs
  • Timing information for each of the stimulation programs is determined based on the target programming pattern and its timing information.
  • the target programming mode can indicate one or more stimulation programs
  • the user can set the timing information of the target programming mode to synchronize the timing information of multiple stimulation programs to meet the needs of different patients in practical applications .
  • the controller is further configured to obtain timing information of each stimulation program in the following manner:
  • the target programming mode indicates a single stimulation program
  • the target programming mode indicates a plurality of stimulation programs
  • determining the timing of each of the stimulation programs based on the timing information of the target programming mode, the duration of each of the stimulation programs, and the ordering of the plurality of stimulation programs timing information.
  • the beneficial effect of this technical solution is that: when the target programming mode indicates a single stimulation program, the form of electrical stimulation provided is single within the time period corresponding to the timing information of the target programming mode; when the target programming mode indicates multiple stimulation programs When programming, electrical stimulation using multiple stimulation programs can be provided sequentially within the time period corresponding to the timing information of the target programming mode.
  • the controller is further configured to:
  • the remaining time period is obtained by removing the overlapping time period from the second time period, and the existing programmed control is updated using the remaining time period Timing information for the mode.
  • the beneficial effect of this technical solution is: when the timing information of the target program control mode conflicts with the timing information of the existing program control mode that has been set before, the timing information of the target program control mode shall prevail, and the timing information of the existing program control mode The corresponding second time period is deduplicated, the timing information of the existing program control mode is updated, and the timing information of the target program control mode does not change, which can reflect the adjustment intention of the user and conform to the user's preference.
  • the controller is further configured to:
  • the timing information of the existing programmed mode is removed.
  • the beneficial effect of this technical solution is that: when the overlapping time period is the whole of the second time period, the timing information of the existing program control mode can be removed, and the program control mode corresponding to the second time period changes from the existing program control mode to the target program control mode.
  • the controller is further configured to:
  • the positions of the two sliders are respectively used to indicate the start time and end time corresponding to the target program control mode
  • the sliding operation is an operation of sliding one slider or an operation of sliding two sliders.
  • the beneficial effect of the technical solution is that: by setting the dial and the slider, the start time and the end time can be clearly and intuitively reflected by the position of the slider on the dial, which is convenient for the user to set timing information.
  • the controller is further configured to obtain the timing information of the target program control mode in the following manner:
  • Timing information for the target programmed mode is obtained based on the valid operation.
  • the sliding operation can be the operation of sliding one slider, or the operation of sliding two sliders.
  • timing information of the target program control mode can be obtained, which reduces the operation difficulty of the user's timing setting.
  • timing information can be set, which can give users positive feedback and greatly reduce the user's psychological Burden, improve user experience.
  • the controller is further configured to obtain the timing information of the target program control mode in the following manner:
  • the beneficial effect of this technical solution is: when the user slides a slider and the operation of sliding the slider is determined to be valid, the timing information of the target program control mode is obtained according to the position of the slider; when the user slides two sliders , only the operation of sliding the two sliders is judged to be valid, and the timing information of the target program control mode is obtained according to the positions of the two sliders.
  • Timing information cannot be set when the operation of a slider is judged to be valid.
  • the program-controlled equipment of this application has a certain threshold in the setting of timing information. Only the user can operate stably in a rational and calm state. The timing information can be set to ensure the safety of the user.
  • the timing information of the target program-controlled mode can be obtained only when the operations corresponding to all the sliders that are slid are valid, which can further avoid Misuse.
  • a sliding slider is used as a target slider, and the process of detecting whether the operation of sliding the target slider is valid is as follows:
  • the beneficial effect of this technical solution is: by detecting the position of each track point of the sliding path to determine whether the operation of the sliding target slider is valid, only when the positions of each track point are in the preset sliding area, it is determined to slide the target slider. The operation of the block is effective, and then the timing information is obtained, so that the user's misoperation can be avoided.
  • the controller is further configured to detect whether the operation of sliding the target slider is valid in the following manner:
  • the reference path corresponding to the sliding path is obtained, and the reference path is a preset Assuming a part of the circular path and the path direction of the reference path is determined by the path direction of the sliding path, the preset circular path is in the preset sliding area;
  • the beneficial effect of this technical solution is: use two-stage detection process to judge whether the sliding operation is valid, only when it is judged that the sliding operation is valid, can the timing information of the target program control mode be obtained, when the first stage detects the timing information of each track point of the sliding path When the positions are all in the preset sliding area, it does not directly determine that the sliding operation is valid, but enters the second stage of detection. When the detected similarity is not less than the preset similarity threshold, it is determined that the sliding operation is valid, and then the timing information is obtained.
  • the two-stage detection process can play the role of double insurance, preventing users from setting unreasonable timing information due to misoperation, and ensuring the safety of patients.
  • the first stage it is detected whether the positions of the track points of the sliding path are all in the preset sliding area, and when it is detected that the positions of the track points of the sliding path are all in the preset sliding area, it indicates that The user may have the intention to set timing information, and enter the second stage at this time; in the second stage, based on the starting point, end point and path direction of the sliding path, the reference path corresponding to the sliding path is obtained, and the similarity between the sliding path and the reference path is obtained. It is detected whether the similarity is not less than the preset similarity threshold, and when the similarity is not smaller than the preset similarity threshold, it can be determined that the sliding operation is not a wrong operation, and the sliding operation is valid.
  • the ultimate goal is to judge the real intention of the user's operation based on the validity judgment result, so that the set timing information meets the user's psychological expectations, thereby improving the user experience.
  • the controller is further configured to obtain the reference path in the following manner:
  • the path between the starting point and the end point of the reference path is taken as the reference path from the preset circular path.
  • the beneficial effect of this technical solution is: the point on the preset circular path closest to the starting point of the sliding path is used as the starting point of the reference path, and the point on the preset circular path closest to the end point of the sliding path is used as the end point of the reference path, Intercept the path from the start point to the end point of the reference path along the sliding path in the preset circular path as the reference path.
  • the reference path thus obtained is more suitable for the sliding path, and it is more reasonable to obtain the corresponding timing information based on the reference path. , which can truly reflect the user's intention when setting the timing information.
  • the two sliders include a start slider for indicating a start time and an end slider for indicating an end time;
  • the vector pointing to the start slider from the center of the dial is taken as the first vector
  • the vector pointing to the end slider from the center of the dial is taken as the second vector
  • the first vector is along the direction of the dial
  • the included angle from the clockwise direction to the second vector does not exceed 180 degrees.
  • the clockwise direction of the dial is selected as the extension direction from the start time to the end time, and the time period corresponding to the start time to the end time does not exceed the time period corresponding to half of the dial.
  • the period of time around the dial is 24 hours.
  • the positions of the two sliders correspond to 23:00 and 1:00 in turn, determine the slider corresponding to 23:00 as the start slider, and 1:00 The corresponding slider is the end slider, and the time period determined by this is from 23:00 of the current day to 1:00 of the next day (the duration is 2 hours), not from 1:00 of the current day to 23:00 of the current day ( The duration is 22 hours), this method is more in line with the user's operating habits.
  • the controller is further configured to:
  • the touch screen is used to receive a synchronous operation, and in response to the synchronous operation, the clock information of the stimulator and the clock information of the program-controlled device are synchronously processed.
  • the beneficial effect of the technical solution is that by synchronizing the clock information of the stimulator and the clock information of the program-controlled device, it is possible to avoid the timing information setting deviation of the stimulator and the program-controlled device due to asynchronous clock information.
  • the controller is further configured to:
  • the user When it is detected that the duration corresponding to the timing information of the target program control mode is longer than the preset duration corresponding to the patient, the user is prompted to re-operate.
  • the beneficial effect of this technical solution is that: patients with different disease types are allowed to receive stimulation for different durations, and the corresponding preset duration is determined according to the patient's disease type, so that the timing information can only be set within the range allowed by the corresponding preset duration , to protect the life safety of patients.
  • the controller is further configured to:
  • a preset tissue corresponding to the patient's disease type is acquired as a target tissue corresponding to the patient.
  • the beneficial effect of the technical solution is that patients with different disease types have different body tissues to be stimulated, and the corresponding target tissue is determined according to the disease type of the patient, so as to apply electrical stimulation to the target tissue of the patient in a targeted manner to meet the needs of practical applications.
  • the stimulation parameter is one or more of a voltage pulse width parameter, an amplitude parameter, and a frequency parameter.
  • the target parameter can be any one of the pulse width parameter, amplitude parameter and frequency parameter of the voltage, so that the program-controlled device can control the stimulator to apply corresponding electrical stimulation to the patient based on the configuration parameter value of the target parameter , to meet the needs of practical applications.
  • the patient's disease type includes one or more of epilepsy, tremor, Parkinson's disease, depression, obsessive-compulsive disorder, Alzheimer's disease, and drug addiction.
  • the beneficial effect of the technical solution is that the stimulators in patients with different types of diseases can be controlled by using the program-controlled equipment, and the scope of application is wide.
  • the program-controlled device further includes the touch screen and a communication module, and the controller is electrically connected to the touch screen and the communication module, respectively;
  • the touch screen is configured to receive user operations, and the communication module is configured to realize data interaction between the program-controlled device and the stimulator.
  • the beneficial effect of the technical solution is that the touch screen and the communication module can be arranged on the program-controlled equipment, so that the program-controlled equipment has the function of man-machine interaction and communication.
  • the implantable neurostimulation system includes the programmable device arranged outside the patient's body and a stimulator implanted in the patient's body;
  • the stimulator is configured to generate electrical stimulation and apply the electrical stimulation to target tissue of the patient;
  • the programmed device is communicatively connected to the stimulator, the programmed device comprising a controller:
  • the controller is configured to:
  • the touch screen Utilize the touch screen to receive a sliding operation, and in response to the sliding operation, obtain the timing information of the stimulation program, the stimulation program is used to indicate the identification and parameter value of the stimulation parameter of the stimulator, and the timing information is used to indicate the start time and end time;
  • control commands are generated and sent to the stimulator.
  • the implantable neurostimulation system can meet the different stimulation needs of different patients, has a wide range of applications, and has a better user experience; moreover, the user can set timing information through sliding operations, which is better than pressing buttons.
  • the method of step-by-step operation adjustment and the method of directly inputting specific values greatly reduce the user's operation steps, making the setting of timing information faster and more convenient, and further improving the user's experience.
  • FIG. 1 is a schematic flowchart of a method for controlling a program-controlled device provided in an embodiment of the present application
  • Fig. 2 is a schematic flow chart of obtaining timing information of a stimulation program provided by an embodiment of the present application
  • FIG. 3 is a schematic flowchart of a part of a method for controlling a program-controlled device provided in an embodiment of the present application
  • FIG. 4 is a partial flow diagram of another method for controlling a program-controlled device provided in an embodiment of the present application.
  • Fig. 5 is a schematic diagram of a display interface of a touch screen provided by an embodiment of the present application.
  • FIG. 6 is a schematic flow diagram of obtaining timing information of a target program control mode provided by an embodiment of the present application.
  • FIG. 7 is a schematic flow diagram for detecting whether a sliding operation is valid provided by an embodiment of the present application.
  • Fig. 8 is another schematic flow diagram for detecting whether the sliding operation is valid provided by the embodiment of the present application.
  • FIG. 9 is a schematic flowchart of obtaining a reference path provided by an embodiment of the present application.
  • FIG. 10 is a schematic flowchart of another method for obtaining configuration parameter values of target parameters provided by the embodiment of the present application.
  • Fig. 11 is a structural block diagram of a program-controlled device provided by an embodiment of the present application.
  • Fig. 12 is a structural block diagram of an implantable nerve stimulation system provided by an embodiment of the present application.
  • At least one means one or more, and “multiple” means two or more.
  • “And/or” describes the association relationship of associated objects, indicating that there may be three types of relationships, for example, A and/or B, which can mean: A exists alone, A and B exist at the same time, and B exists alone, where A, B can be singular or plural.
  • the character “/” generally indicates that the contextual objects are an “or” relationship.
  • “At least one of the following" or similar expressions refer to any combination of these items, including any combination of single or plural items.
  • At least one item (piece) of a, b or c can represent: a, b, c, a and b, a and c, b and c or a and b and c, wherein a, b and c can be It can be single or multiple. It should be noted that "at least one item (item)” can also be interpreted as “one item (item) or multiple items (item)”.
  • words such as “exemplary” or “for example” are used to mean an example, illustration or description. Any embodiment or design described herein as “exemplary” or “for example” is not to be construed as preferred or advantageous over other embodiments or designs. Rather, the use of words such as “exemplary” or “such as” is intended to present related concepts in a concrete manner.
  • An implantable neurostimulator system (an implanted medical system) mainly includes a stimulator implanted in a patient (ie, an implanted neurostimulator) and a program-controlled device placed outside the patient's body.
  • the program-controlled device may include an in vitro controller, and the program-controlled device may also be an in vitro controller.
  • the existing neuromodulation technology mainly uses stereotaxic surgery to implant electrodes in specific structures (i.e., targets) in the body, and the stimulator implanted in the patient sends electrical pulses to the targets through the electrodes to regulate the corresponding neural structures and networks. Electrical activity and its function, thereby improving symptoms and relieving pain.
  • the stimulator can be an implantable electrical nerve stimulation device, an implantable cardiac electrical stimulation system (also known as a cardiac pacemaker), an implantable drug infusion device (Implantable Drug Delivery System, referred to as IDDS) and a wire switch. Any one of the connected devices.
  • Implantable electrical nerve stimulation devices are, for example, Deep Brain Stimulation (DBS), Implantable Cortical Nerve Stimulation (CNS), Implantable Spinal Cord Stimulation , referred to as SCS), implanted sacral nerve stimulation system (Sacral Nerve Stimulation, referred to as SNS), implanted vagus nerve stimulation system (Vagus Nerve Stimulation, referred to as VNS) and so on.
  • DBS Deep Brain Stimulation
  • CNS Implantable Cortical Nerve Stimulation
  • SCS Implantable Spinal Cord Stimulation
  • SNS implanted sacral nerve stimulation system
  • Vagus Nerve Stimulation referred to as VNS
  • VNS vagus Nerve Stimulation
  • the stimulator can include IPG, extension wires and electrode wires.
  • IPG implantable pulse generator, implantable pulse generator
  • IPG is set in the patient's body, receives the program control instructions sent by the program control device, and provides controllable stimulation to the tissues in the body relying on sealed batteries and circuits.
  • Electrical stimulation energy through implanted extension leads and electrode leads, delivers one or two controlled, specific electrical stimuli to specific areas of tissue in the body.
  • the extension wire is used in conjunction with the IPG as a transmission medium for the electrical stimulation signal, and transmits the electrical stimulation signal generated by the IPG to the electrode wire.
  • Electrode leads deliver electrical stimulation to specific areas of tissue in the body through multiple electrode contacts.
  • the stimulator is provided with one or more electrode wires on one side or both sides, and a plurality of electrode contacts are arranged on the electrode wires, and the electrode contacts can be arranged uniformly or non-uniformly in the circumferential direction of the electrode wires.
  • the electrode contacts may be arranged in an array of 4 rows and 3 columns (a total of 12 electrode contacts) in the circumferential direction of the electrode wire.
  • Electrode contacts may include stimulation electrode contacts and/or collection electrode contacts.
  • the electrode contacts can be in the shape of, for example, a sheet, a ring, or a dot.
  • the stimulated body tissue may be the patient's brain tissue, and the stimulated site may be a specific part of the brain tissue.
  • the stimulated site is generally different, the number of stimulation contacts (single source or multi-source) used, one or more channels (single-channel or multi-channel) specific electrical stimulation signals
  • the application and stimulus parameter data are also different.
  • the embodiment of the present application does not limit the applicable disease types, which may be the applicable disease types for deep brain stimulation (DBS), spinal cord stimulation (SCS), pelvic stimulation, gastric stimulation, peripheral nerve stimulation, and functional electrical stimulation.
  • DBS disorders that DBS can be used to treat or manage include, but are not limited to: spasticity disorders (e.g., epilepsy), pain, migraine, psychiatric disorders (e.g., major depressive disorder (MDD)), bipolar disorder, anxiety disorders, Post-traumatic stress disorder, hypodepression, obsessive-compulsive disorder (OCD), conduct disorder, mood disorder, memory disorder, mental status disorder, mobility disorder (eg, essential tremor or Parkinson's disease), Huntington's disease, Al Alzheimer's disease, drug addiction, autism, or other neurological or psychiatric conditions and impairments.
  • spasticity disorders e.g., epilepsy
  • pain migraine
  • psychiatric disorders e.g., major depressive disorder (MDD)
  • bipolar disorder e.g., anxiety disorders, Post-traumatic stress disorder, hypodepression, obsessive-compulsive disorder (OCD)
  • OCD obsessive-compulsive disorder
  • conduct disorder mood disorder
  • the program-controlled device when the program-controlled device and the stimulator establish a program-controlled connection, can be used to adjust the stimulation parameters of the stimulator (different stimulation parameters correspond to different electrical stimulation signals), and the stimulator can also be used to sense the deep brain of the patient.
  • the bioelectric activity of the stimulator can be used to collect the electrophysiological signal, and the stimulation parameters of the electrical stimulation signal of the stimulator can be adjusted continuously through the collected electrophysiological signal.
  • Stimulation parameters can include: frequency (for example, the number of electrical stimulation pulse signals per unit time 1s, unit is Hz), pulse width (duration of each pulse, unit is ⁇ s), amplitude (generally expressed by voltage, that is, The intensity of each pulse, the unit is V), timing (for example, it can be continuous or triggered), stimulation mode (including one or more of current mode, voltage mode, timed stimulation mode and cycle stimulation mode), doctor's control upper limit One or more of upper and lower limits (range adjustable by doctors) and upper and lower limits of patient control (range adjustable by patients).
  • frequency for example, the number of electrical stimulation pulse signals per unit time 1s, unit is Hz
  • pulse width duration of each pulse, unit is ⁇ s
  • amplitude generally expressed by voltage, that is, The intensity of each pulse, the unit is V
  • timing for example, it can be continuous or triggered
  • stimulation mode including one or more of current mode, voltage mode, timed stimulation mode and cycle stimulation mode
  • doctor's control upper limit One or more of upper and lower limits (range adjustable
  • various stimulation parameters of the stimulator can be adjusted in current mode or voltage mode.
  • the program-controlled device may be a doctor-programmed device (ie, a program-controlled device used by a doctor) or a patient-programmed device (ie, a program-controlled device used by a patient).
  • the doctor's program-controlled device can be, for example, a tablet computer, a notebook computer, a desktop computer, a mobile phone and other smart terminal devices equipped with program-controlled software.
  • the patient program-controlled device can be, for example, smart terminal devices such as tablet computers, notebook computers, desktop computers, and mobile phones equipped with program-controlled software, and the patient program-controlled device can also be other electronic devices with program-controlled functions (such as chargers with program-controlled functions, data collection device).
  • the embodiment of the present application does not limit the data interaction between the doctor's program-controlled device and the stimulator.
  • the doctor's program-controlled device can perform data interaction with the stimulator through the server and the patient's program-controlled device.
  • the doctor’s program-controlled device can interact with the stimulator through the patient’s program-controlled device, and the doctor’s program-controlled device can also directly interact with the stimulator.
  • the patient programmable device may include a host (communicating with the server) and a slave (communicating with the stimulator), the host and slave being communicatively connected.
  • the doctor's program-controlled equipment can exchange data with the server through the 3G/4G/5G network
  • the server can exchange data with the host through the 3G/4G/5G network
  • the host can exchange data with the slave through the Bluetooth protocol/WIFI protocol/USB protocol.
  • the sub-machine can exchange data with the stimulator through the 401MHz-406MHz working frequency band/2.4GHz-2.48GHz working frequency band, and the doctor's program-controlled equipment can directly exchange data with the stimulator through the 401MHz-406MHz working frequency band/2.4GHz-2.48GHz working frequency band interact.
  • an embodiment of the present application provides a control method for a program-controlled device, which is applied to an implantable neurostimulation system, and the implanted neurostimulation system includes the program-controlled device arranged outside the patient's the stimulator in the patient;
  • the programmable device is communicatively connected to the stimulator.
  • the method includes steps S101 to S102.
  • Step S101 Use the touch screen to receive a sliding operation, and in response to the sliding operation, obtain timing information of a stimulation program, the stimulation program is used to indicate the identification and parameter value of the stimulation parameter of the stimulator, and the timing information is used to indicate start time and end time;
  • Step S102 Based on the stimulation program and its timing information, generate a control instruction and send it to the stimulator, so that the stimulator generates electrical stimulation according to the control instruction and applies the electrical stimulation to the target tissue of the patient. electrical stimulation.
  • acquiring the timing information of a stimulation program may be setting timing information for a stimulation program that has not been set with timing information (for example, a newly added stimulation program).
  • acquiring the timing information of the stimulation program may be to modify the timing information of the stimulation program for which the timing information has been set.
  • the stimulation parameters of the stimulation program can be adjusted at any time, and the parameter values of the stimulation parameters corresponding to the stimulation program can be set or modified (using the touch screen).
  • the user can flexibly set the timing information corresponding to the stimulation program.
  • the program-controlled equipment of the present application can meet the different stimulation needs of different patients, and has a wide range of applications.
  • the user can set the timing information through the sliding operation.
  • the user's operation steps are greatly reduced, and the timing information is set faster. Convenience and further enhance the user experience.
  • the stimulator can be an implantable electrical nerve stimulation device, an implantable cardiac electrical stimulation system (also known as a cardiac pacemaker), an implantable drug infusion device (Implantable Drug Delivery System, referred to as IDDS) and a lead transfer device any of the.
  • Implantable electrical nerve stimulation devices are, for example, Deep Brain Stimulation (DBS), Implantable Cortical Nerve Stimulation (CNS), Implantable Spinal Cord Stimulation , referred to as SCS), implanted sacral nerve stimulation system (Sacral Nerve Stimulation, referred to as SNS), implanted vagus nerve stimulation system (Vagus Nerve Stimulation, referred to as VNS) and so on.
  • DBS Deep Brain Stimulation
  • CNS Implantable Cortical Nerve Stimulation
  • SCS Implantable Spinal Cord Stimulation
  • SNS implanted sacral nerve stimulation system
  • Vagus Nerve Stimulation referred to as VNS
  • the stimulator is set in the patient's body for providing electrical stimulation
  • Program-controlled devices may include, but are not limited to: smart phones (such as Android phones, iOS phones, etc.), tablet computers, portable personal computers, mobile Internet devices (Mobile Internet Devices, MID) and other devices, which are not limited in the embodiments of this application.
  • the program-controlled device may further include the touch screen and a communication module.
  • the touch screen is configured to receive user operations, and the communication module is configured to realize data interaction between the program-controlled device and the stimulator.
  • the touch screen and the communication module can be set on the program-controlled device, so that the program-controlled device has human-computer interaction function and communication function.
  • a programmable device may include a physician-programmed device and/or a patient-programmed device.
  • the patient program control device is equipped for the patient, and the patient can use the patient program control device to adjust the stimulation parameters of the corresponding stimulator by himself.
  • the corresponding preset adjustment range can be set based on the patient's disease information, and the patient can only adjust the stimulation parameters of the corresponding stimulator within the corresponding preset adjustment range.
  • the doctor's program-controlled device is equipped for doctors.
  • a doctor's program-controlled device can use the communication module to perform data interaction with the stimulators of multiple patients.
  • the communication module may include a wired communication module and/or a wireless communication module.
  • the wired communication module may include one or more of an optical fiber communication unit, a coaxial cable communication unit, an open wire communication unit, a waveguide communication unit, and a photoelectric communication unit; the wireless communication module may include a 4G communication unit, a 5G communication unit, a WIFI communication unit, One or more of near field communication unit, WiGig communication unit, Bluetooth communication unit, ZigBee communication unit, microwave communication unit, satellite communication unit and atmospheric laser communication unit.
  • the wired communication module is relatively stable, with high reliability and high transmission rate; the wireless communication module has a longer communication distance and is not limited by wires, and has certain mobility. It can communicate through a wireless connection in a mobile state, and the cost is relatively low. Low.
  • the touch screen may include any one of a resistive touch screen, a capacitive touch screen, and a surface acoustic wave screen.
  • the stimulation parameter may be one or more of a voltage pulse width parameter, an amplitude parameter, and a frequency parameter.
  • the target parameter can be any one of the pulse width parameter, amplitude parameter and frequency parameter of the voltage, so that the program-controlled device can control the stimulator to apply corresponding electrical stimulation to the patient based on the configuration parameter value of the target parameter, which meets the requirements of practical applications. need.
  • the stimulation parameters may also include one or more of stimulation mode and energy output mode.
  • the stimulation mode is used to indicate monopolar stimulation or multipolar stimulation
  • the energy output mode is used to indicate constant voltage stimulation or constant current stimulation.
  • Constant voltage stimulation means that the output voltage is fixed, and the current changes with the change of resistance
  • constant current stimulation means that the output current is fixed, and the voltage changes with the change of resistance
  • the step S101 may include steps S201 to S202.
  • Step S201 using the touch screen to receive the sliding operation, and in response to the sliding operation, acquiring timing information of a target programming mode, the target programming mode being used to indicate at least one of the stimulation programs;
  • Step S202 Determine the timing information of each stimulation program based on the target programming mode and its timing information.
  • the present application does not limit the number of stimulation programs indicated by the target programming mode, which may be 1, 3, 6 or 8.
  • the target programming mode can indicate one or more stimulation programs, and the user can synchronously set the timing information of multiple stimulation programs by setting the timing information of the target programming mode to meet the needs of different patients in practical applications.
  • the target programming mode indicates stimulation program a
  • the stimulation program a indicates: pulse width 60 ⁇ s, amplitude 0.2 V, frequency 80 Hz
  • the timing information of the target programming mode is, for example: 12:00 to 15:00, so it can be
  • the timing information of the stimulation program a is determined to be from 12:00 to 15:00, and then the electrical stimulation corresponding to the stimulation program a is applied to the patient from 12:00 to 15:00.
  • the timing information of the target programming mode is distributed equally or according to a preset ratio to determine the timing information of each stimulation program.
  • the target programming mode sequentially indicates stimulation program b, stimulation program c and stimulation program d.
  • the timing information of the target programming mode is from 15:00 to 16:00
  • the timing information of stimulation program b is from 15:00 to 15:20
  • the timing information of stimulation program c is from 15:20 to 15:40
  • the timing information of stimulation program d is from 15:00 to 15:40
  • Timing information is from 15:40 to 16:00.
  • the step S202 may include:
  • the target programming mode indicates a single stimulation program
  • the target programming mode indicates a plurality of stimulation programs
  • determining the timing of each of the stimulation programs based on the timing information of the target programming mode, the duration of each of the stimulation programs, and the ordering of the plurality of stimulation programs timing information.
  • the target programming mode indicates a single stimulation program
  • the form of electrical stimulation provided is single within the time period corresponding to the timing information of the target programming mode; when the target programming mode indicates multiple stimulation programs, it can be During the time period corresponding to the timing information of the target programming mode, electrical stimulation is provided sequentially using multiple stimulation programs.
  • the target programming pattern sequentially indicates stimulation program e, stimulation program f and stimulation program g.
  • the duration of stimulation program e is 120s
  • the duration of stimulation program f is 90s
  • the duration of stimulation program g is 150s
  • the timing information of the target program control mode is from 15:00 to 16:00, then from 15:00 to 16:00, electrical stimulation can be applied to the patient for 10 stimulation cycles, and within each stimulation cycle (0 to 360s),
  • the timing information of stimulation program e is from 0 to 120s
  • the timing information of stimulation program f is from 120 to 210s
  • the timing information of stimulation program g is from 210 to 360s.
  • no stimulation that is, the parameter value of the stimulation parameter is zero
  • its form is, for example, a stimulation program bye.
  • the target programming mode sequentially indicates stimulus program h, stimulus program j and stimulus program bye in sequence.
  • the method may further include step S301 to step S302.
  • Step S301 When the first time period corresponding to the timing information of the target program control mode overlaps with the second time period corresponding to the preset timing information of the existing program control mode, determine the overlapping time period;
  • Step S302 When it is detected that the overlapping time period is part of the second time period, remove the overlapping time period from the second time period to obtain a remaining time period, and use the remaining time period to update the Timing information for programmed mode is available.
  • the timing information of the target program control mode shall prevail, and the second corresponding to the timing information of the existing program control mode
  • the time period is deduplicated, and the timing information of the existing program control mode is updated.
  • the timing information of the target program control mode does not change (maintain the user's setting result), which can reflect the user's adjustment intention and meet the user's preference.
  • the first time period corresponding to the timing information of the target program control mode is 2:00 to 5:00
  • the second time period corresponding to the timing information of the existing program control mode is 4:00 to 7:00
  • the overlapping time period is from 4:00 to 5:00
  • the overlapping time period is part of the second time period.
  • the remaining time period 5:00 to 7:00 is obtained, and the remaining time period is used to update
  • the timing information of the existing program control mode is such that the timing information of the existing program control mode indicates 5:00 to 7:00.
  • the method may further include step S303.
  • Step S303 When it is detected that the overlapping time period is the whole of the second time period, remove the timing information of the existing programmed mode.
  • the timing information of the existing program control mode can be removed, and the program control mode corresponding to the second time period changes from the existing program control mode to the target program control mode.
  • the first time period corresponding to the timing information of the target program control mode is 2:00 to 5:00
  • the second time period corresponding to the timing information of the existing program control mode is 4:00 to 5:00
  • the overlapping time period is from 4:00 to 5:00
  • the overlapping time period is the whole of the second time period, and the timing information of the existing program-controlled mode is removed.
  • the timing information of the existing programmed mode may be adjusted (in the form of a delay, etc.) so that the first time period is consistent with the adjusted The second time periods do not coincide. In this case, the timing duration of the existing programmed mode does not change.
  • the first time period corresponding to the timing information of the target program control mode is 2:00 to 5:00
  • the second time period corresponding to the timing information of the existing program control mode is 4:00 to 5:00
  • the overlapping time period is from 4:00 to 5:00
  • the overlapping time period is the whole of the second time period, then adjust the timing information of the existing program control mode.
  • the second time period is from 5:00 to 7:00.
  • the method may also include:
  • the positions of the two sliders are respectively used to indicate the start time and end time corresponding to the target program control mode
  • the sliding operation is an operation of sliding one slider or an operation of sliding two sliders.
  • the start time and the end time can be clearly and intuitively reflected by the position of the slider on the dial, which is convenient for the user to set timing information.
  • the present application does not limit the shape of the slider, and the shape of the slider may be any one of circle, triangle, rectangle, and polygon.
  • the time span represented by one week of the dial can be 6 hours, 8 hours, 12 hours or 24 hours.
  • the dial is sequentially provided with N scales in the clockwise direction, and the difference between the time corresponding to the kth scale and the time corresponding to the k-1th scale corresponds to the k+1th scale The difference between the moment of and the moment corresponding to the kth tick is different.
  • N is an integer greater than 2
  • k is an integer greater than 1 and less than N.
  • the dial is provided with 6 scales in the clockwise direction, and the times represented by these 6 scales are 0:00, 8:00, 14:00, 19:00, 21:00 and 23:00.
  • the two sliders may include a start slider for indicating the start time and an end slider for indicating the end time, wherein the setting range of the start time and the end time is 0 on the same day :00 to 23:59 (or 0:00:00 to 23:59:59), and the sliders corresponding to the start slider and the end slider are constant and will not change due to the user's sliding operation.
  • start slider and the end slider may be displayed in the same color and/or in the same shape.
  • start slider and the end slider may be displayed in different colors and/or different shapes, respectively.
  • the start slider is displayed as blue slider a on the touch screen
  • the end slider is displayed as yellow slider b on the touch screen.
  • the time corresponding to the position of slider a is 8:00, and the time corresponding to slider b is 22:00, the start time is 8:00 of the day, and the end time is 22:00 of the day.
  • green can be used to display the circular arc area corresponding to the timing information of the target program control mode (there is a certain width in the radial direction).
  • the position corresponding to the end moment of the program is the end point, from the start point to the end point, thus intuitively displaying the time period corresponding to the timing information of the target program control mode.
  • the timing information of the program control mode is the preset timing information of an existing program control mode.
  • red can be used to display the circular arc area corresponding to the timing information of the existing program control mode (there is a certain width in the radial direction).
  • the position corresponding to the end time of the program-controlled mode is the end point, pointing from the starting point to the end point, thus intuitively displaying the time period corresponding to the timing information of the existing program-controlled mode, and reminding the user that there is a corresponding time period corresponding to the arc area.
  • the step S201 may include steps S401 to S402.
  • Step S401 respectively detecting whether the operation of sliding each slider is valid, so as to obtain valid operations in the sliding operations;
  • Step S402 Obtain timing information of the target program control mode based on the effective operation.
  • the sliding operation can be the operation of sliding one slider, or the operation of sliding two sliders.
  • the operation of sliding the slider is determined to be valid, according to the slider's position to obtain the timing information of the target program-controlled mode;
  • the position of the target program-controlled mode is obtained according to the position of the slider corresponding to the valid operation. timing information.
  • timing information of the target program control mode can be obtained, which reduces the operation difficulty of the user's timing setting.
  • timing information can be set, which can give users positive feedback and greatly reduce the user's psychological Burden, improve user experience.
  • the step S201 may include:
  • the timing information of the target programming mode is obtained according to the position of the slider; when the user slides two sliders, only two The operations of the sliders are all judged to be valid, and the timing information of the target program control mode is obtained according to the positions of the two sliders.
  • Timing information cannot be set when the operation of a slider is judged to be valid.
  • the program-controlled equipment of this application has a certain operating threshold in the setting of timing information. Only when the user is in a rational and calm state can he Operation can set the timing information, so as to ensure the safety of the user's life.
  • the timing information of the target program-controlled mode can be obtained, which can further Avoid misuse.
  • the program-controlled device of this application can set the timing information through a simple sliding operation. As far as the doctor who uses the program-controlled device is concerned, the setting efficiency is improved. At the same time, the patient who uses the program-controlled device is also considered. This setting timing information, thereby achieving people-oriented, embodies humanized care.
  • a sliding slider is used as a target slider, and the process of detecting whether the operation of sliding the target slider is valid may include steps S501 to S503.
  • Step S501 Obtain the sliding path corresponding to the target slider based on the operation of sliding the target slider, and detect whether the positions of the track points of the sliding path are all in the preset sliding area;
  • Step S502 When the position of at least one track point of the sliding path is not in the preset sliding area, determine that the operation of sliding the target slider is invalid;
  • Step S503 When the position of each track point of the sliding path is within the preset sliding area, determine that the operation of sliding the target slider is valid.
  • the process of detecting whether the operation of sliding the target slider is valid may include steps S601 to S604.
  • Step S601 When the position of each track point of the sliding path is in the preset sliding area, based on the starting point, the ending point and the path direction of the sliding path, obtain a reference path corresponding to the sliding path, the reference The path is a part of a preset circular path and the path direction of the reference path is determined by the path direction of the sliding path, the preset circular path is in the preset sliding area;
  • Step S602 Detect whether the similarity between the sliding path and the reference path is not less than a preset similarity threshold
  • Step S603 When the similarity is less than the preset similarity threshold, determine that the operation of sliding the target slider is invalid;
  • Step S604 When the similarity is not less than the preset similarity threshold, determine that the operation of sliding the target slider is valid.
  • the shape of the predetermined sliding area may be a ring concentric with the predetermined circular path.
  • a two-stage detection process is used to determine whether the sliding operation is valid, and only when it is judged that the sliding operation is valid can the timing information of the target program control mode be obtained.
  • the first stage detects that the positions of each track point of the sliding path are in the preset When sliding the area, it does not directly determine that the sliding operation is valid, but enters the second stage of detection.
  • the detected similarity is not less than the preset similarity threshold, it is determined that the sliding operation is valid, and then the timing information is obtained.
  • Two-stage detection The process can play the role of double insurance, preventing users from setting unreasonable timing information due to misoperation, and ensuring the safety of patients.
  • the first stage it is detected whether the positions of the track points of the sliding path are all in the preset sliding area, and when it is detected that the positions of the track points of the sliding path are all in the preset sliding area, it indicates that The user may have the intention to set timing information, and enter the second stage at this time; in the second stage, based on the starting point, end point and path direction of the sliding path, the reference path corresponding to the sliding path is obtained, and the similarity between the sliding path and the reference path is obtained. It is detected whether the similarity is not less than the preset similarity threshold, and when the similarity is not smaller than the preset similarity threshold, it can be determined that the sliding operation is not a wrong operation, and the sliding operation is valid.
  • the ultimate goal is to judge the real intention of the user's operation based on the validity judgment result, so that the set timing information meets the user's psychological expectations, thereby improving the user experience.
  • the similarity between the sliding path and the reference path can be obtained in the following manner:
  • the preset deep learning model can be trained according to the similarity training data to obtain the similarity model. Just input the sliding path and the reference path into the similarity model, and the corresponding similarity can be automatically generated in real time, and the degree of intelligence is relatively high. high.
  • a preset deep learning model can be obtained. Through the learning and tuning of the preset deep learning model, Establish the functional relationship from input to output. Although the functional relationship between input and output cannot be found 100%, it can approach the actual correlation as much as possible.
  • the similarity model trained by this can output the corresponding similarity in real time. And the reliability of the output result is high.
  • the preset similarity threshold can be obtained in the following manner:
  • a similarity threshold corresponding to the patient's disease type is acquired as the preset similarity threshold.
  • the ability of hand control of patients with different disease types may be different.
  • Parkinson's patients with poor hand control can deviate from the preset circular path when sliding It may be larger, but the similarity may be lower.
  • different preset similarity thresholds are adopted, so that the program-controlled equipment can support patients with poor hand control to perform sliding operations, which greatly reduces the patient's use of program-controlled devices. Difficulty in operating the device.
  • the similarity threshold corresponding to Parkinson's disease is 60%
  • the similarity threshold corresponding to depression is 80%
  • the similarity threshold corresponding to drug addiction is 85%.
  • the patient Zhang San is a Parkinson's patient
  • the preset similarity threshold of Zhang San is 60%.
  • the lowest one of the similarity thresholds corresponding to all disease types of the patient can be used as the preset similarity threshold of the patient, or can be used among the similarity thresholds corresponding to all disease types of the patient The highest one is used as the preset similarity threshold for this patient.
  • steps S701 to S703 may be used to obtain the reference path:
  • Step S701 Find a point on the preset circular path that is closest to the starting point of the sliding path as the starting point of the reference path;
  • Step S702 Find a point on the preset circular path that is closest to the end point of the sliding path as the end point of the reference path;
  • Step S703 Based on the path direction of the sliding path, take the path between the start point and the end point of the reference path from the preset circular path as the reference path.
  • the point on the preset circular path closest to the starting point of the sliding path is used as the starting point of the reference path
  • the point on the preset circular path closest to the end point of the sliding path is used as the end point of the reference path to intercept the preset circular path
  • the path direction along the sliding path from the start point to the end point of the reference path is used as the reference path.
  • the reference path thus obtained is more suitable for the sliding path. It is more reasonable to obtain the corresponding timing information according to the reference path, which can truly reflect the user. Intent when setting timing information.
  • the two sliders include a start slider for indicating a start time and an end slider for indicating an end time;
  • the vector pointing to the start slider from the center of the dial is taken as the first vector
  • the vector pointing to the end slider from the center of the dial is taken as the second vector
  • the first vector is along the direction of the dial
  • the included angle from the clockwise direction to the second vector does not exceed 180 degrees.
  • the clockwise direction of the dial is selected as the extension direction from the start time to the end time, and the time period corresponding to the start time to the end time does not exceed the time period corresponding to half of the dial.
  • the time period around the dial is 24 hours (that is, the 24-hour system is used), and when the positions of the two sliders correspond to 23:00 and 1:00 in sequence, the slider corresponding to 23:00 is determined to be The start slider, the slider corresponding to 1:00 is the end slider, and the time period determined by this is from 23:00 of the current day to 1:00 of the next day (the duration is 2 hours), not 1:00 of the current day Until 23:00 of the day (the duration is 22 hours), this method is more in line with the user's operating habits.
  • the times corresponding to the positions of the two sliders are 5:00 and 15:00 in turn, and the slider corresponding to 5:00 is determined to be the start slider, and the slider corresponding to 15:00 is the end slider.
  • the time period thus determined is from 5:00 to 15:00 of the current day (the duration is 10 hours).
  • the sliders corresponding to the start slider and the end slider are not constant, and the specific allocation of the two sliders is determined by the user's sliding operation.
  • the two sliders are slider c and slider d respectively.
  • slider c is the start of sliding.
  • slider d is the end slider;
  • slider c is the end slider, and slider d for the start slider.
  • the method may further include step S801 to step S802.
  • Step S801 using the touch screen to display the clock information of the stimulator and the clock information of the program-controlled device;
  • Step S802 using the touch screen to receive a synchronous operation, and in response to the synchronous operation, synchronizing the clock information of the stimulator and the clock information of the program-controlled device.
  • the clock information of the stimulator indicates 16:47:20
  • the clock information of the program-controlled device indicates 16:40:20. Synchronize the clock information of the stimulator and the clock information of the program-controlled device, so that the stimulator The clock information is synchronized with the clock information of the program-controlled device, which is 16:40:20.
  • the method may also include:
  • the user When it is detected that the duration corresponding to the timing information of the target program control mode is longer than the preset duration corresponding to the patient, the user is prompted to re-operate.
  • the preset duration corresponding to Parkinson's disease is 8 hours
  • the preset duration corresponding to depression is 3 hours
  • the preset duration corresponding to drug addiction is 7 hours.
  • patient Zhang San is a Parkinson's patient
  • Zhang San's preset duration is 8 hours.
  • the shortest one of the preset time lengths corresponding to all disease types of the patient may be used as the patient's preset time length.
  • the method may also include:
  • a preset tissue corresponding to the patient's disease type is acquired as a target tissue corresponding to the patient.
  • the preset tissue may be brain tissue, and the preset tissue may include one or more of the subthalamic nucleus, medial globus pallidus, ventromedial nucleus of the thalamus, left anterior limb of the internal capsule, left nucleus accumbens, right anterior limb of the internal capsule, and right nucleus accumbens indivual.
  • the preset tissue may be brain tissue formed by multiple brain cells. In other specific applications, the preset tissue can also be a single brain cell.
  • patients with different disease types have different body tissues that receive stimulation, and the corresponding target tissue is determined according to the disease type of the patient, so as to apply electrical stimulation to the target tissue of the patient in a targeted manner to meet the needs of practical applications.
  • the program-controlled device of this application is not limited to the applicable disease types, and the disease types include but are not limited to: spasticity disease (for example, epilepsy), pain, migraine, mental illness (for example, major depressive disorder (MDD)), bipolar disorder , anxiety disorders, post-traumatic stress disorder, hypodepression, obsessive-compulsive disorder (OCD), behavioral disorders, mood disorders, memory disorders, mental status disorders, mobility disorders (eg, tremors or Parkinson's disease), Huntington's disease, Al Alzheimer's disease, drug addiction disorder, or other neurological or psychiatric conditions and impairments.
  • spasticity disease for example, epilepsy
  • pain migraine
  • mental illness for example, major depressive disorder (MDD)
  • bipolar disorder e.g., anxiety disorders, post-traumatic stress disorder, hypodepression, obsessive-compulsive disorder (OCD)
  • OCD obsessive-compulsive disorder
  • behavioral disorders eg, tremors or Parkinson's disease
  • the patient's disease type includes one or more of epilepsy, tremor, Parkinson's disease, depression, obsessive-compulsive disorder, Alzheimer's disease, and drug addiction.
  • the stimulators in patients with different disease types can be controlled by using the program-controlled equipment, and the scope of application is wide.
  • the present application also provides a program-controlled device 100 , whose specific implementation mode is consistent with the implementation mode and achieved technical effect described in the above-mentioned control method embodiment, and part of the content will not be repeated here.
  • the program-controlled device 100 is applied to an implantable neurostimulation system, and the implanted neurostimulation system includes the program-controlled device 100 arranged outside the patient's body and a stimulator implanted in the patient's body;
  • the program-controlled device 100 is communicably connected to the stimulator, and the program-controlled device 100 includes a controller 103;
  • the controller 103 is configured to:
  • the touch screen 101 Utilize the touch screen 101 to receive a sliding operation, and in response to the sliding operation, obtain the timing information of the stimulation program, the stimulation program is used to indicate the identification and parameter value of the stimulation parameter of the stimulator, and the timing information is used to indicate the start time and end time;
  • control instructions are generated and sent to the stimulator, so that the stimulator generates electrical stimulation according to the control instructions and applies the electrical stimulation to the target tissue of the patient.
  • the controller 103 may include at least one memory, at least one processor, and a bus connecting different platform systems.
  • the memory may include one or more of random access memory (RAM), read only memory (ROM) and cache memory.
  • RAM random access memory
  • ROM read only memory
  • cache memory stores a computer program executable by the processor.
  • a bus may represent one or more of several types of bus structures, including a memory bus, a peripheral bus, an accelerated graphics port, or a local bus using any of a variety of bus structures.
  • the controller 103 is configured to obtain timing information of the stimulation program in the following manner:
  • the touch screen 101 uses the touch screen 101 to receive the sliding operation, in response to the sliding operation, acquire timing information of a target programming mode, the target programming mode is used to indicate at least one of the stimulation programs;
  • Timing information for each of the stimulation programs is determined based on the target programming pattern and its timing information.
  • controller 103 is further configured to acquire timing information of each stimulation program in the following manner:
  • the target programming mode indicates a single stimulation program
  • the target programming mode indicates a plurality of stimulation programs
  • determining the timing of each of the stimulation programs based on the timing information of the target programming mode, the duration of each of the stimulation programs, and the ordering of the plurality of stimulation programs timing information.
  • controller 103 is further configured to:
  • the remaining time period is obtained by removing the overlapping time period from the second time period, and the existing programmed control is updated using the remaining time period Timing information for the mode.
  • controller 103 is further configured to:
  • the timing information of the existing programmed mode is removed.
  • controller 103 is further configured to:
  • touch screen 101 uses the touch screen 101 to display a dial, and display two slidable sliders in the circumferential direction of the dial, the positions of the two sliders are respectively used to indicate the start time and end time corresponding to the target program control mode;
  • the sliding operation is an operation of sliding one slider or an operation of sliding two sliders.
  • the controller 103 is further configured to obtain the timing information of the target program control mode in the following manner:
  • Timing information for the target programmed mode is obtained based on the valid operation.
  • the controller 103 is further configured to obtain the timing information of the target program control mode in the following manner:
  • a sliding slider is used as a target slider, and the process of detecting whether the operation of sliding the target slider is valid is as follows:
  • controller 103 is further configured to detect whether the operation of sliding the target slider is valid in the following manner:
  • the reference path corresponding to the sliding path is obtained, and the reference path is a preset Assuming a part of the circular path and the path direction of the reference path is determined by the path direction of the sliding path, the preset circular path is in the preset sliding area;
  • controller 103 is further configured to obtain the reference path in the following manner:
  • the path between the start point and the end point of the reference path is taken from the preset circular path as the reference path.
  • the two sliders include a start slider for indicating a start time and an end slider for indicating an end time;
  • the vector pointing to the start slider from the center of the dial is taken as the first vector
  • the vector pointing to the end slider from the center of the dial is taken as the second vector
  • the first vector is along the direction of the dial
  • the included angle from the clockwise direction to the second vector does not exceed 180 degrees.
  • controller 103 is further configured to:
  • the touch screen 101 is used to receive a synchronous operation, and in response to the synchronous operation, the clock information of the stimulator and the clock information of the program-controlled device 100 are synchronously processed.
  • controller 103 is further configured to:
  • the user When it is detected that the duration corresponding to the timing information of the target program control mode is longer than the preset duration corresponding to the patient, the user is prompted to re-operate.
  • controller 103 is further configured to:
  • a preset tissue corresponding to the patient's disease type is acquired as a target tissue corresponding to the patient.
  • the stimulation parameter is one or more of a voltage pulse width parameter, an amplitude parameter, and a frequency parameter.
  • the patient's disease type includes one or more of epilepsy, tremor, Parkinson's disease, depression, obsessive-compulsive disorder, Alzheimer's disease, and drug addiction.
  • the program-controlled device 100 further includes the touch screen 101 and a communication module 102, and the controller 103 is electrically connected to the touch screen 101 and the communication module 102, respectively;
  • the touch screen 101 is configured to receive user operations, and the communication module 102 is configured to realize data interaction between the program-controlled device 100 and the stimulator.
  • the present application also provides an implantable nerve stimulation system 300, its specific implementation mode is consistent with the implementation mode and achieved technical effect described in the above-mentioned control method embodiment, and part of the content will not be repeated.
  • the implantable nerve stimulation system 300 includes the programmable device 100 arranged outside the patient's body and the stimulator 200 implanted in the patient's body;
  • the stimulator 200 is configured to generate electrical stimulation and apply the electrical stimulation to target tissue of the patient;
  • the program-controlled device 100 is communicably connected with the stimulator 200, and the program-controlled device 100 includes a controller 103:
  • the controller 103 is configured to:
  • the stimulation program is used to indicate the identification and parameter value of the stimulation parameter of the stimulator 200, and the timing information is used to indicate the start time and end time;
  • control commands are generated and sent to the stimulator 200 .
  • the implantable neurostimulation system 300 can meet the different stimulation needs of different patients, has a wide range of applications, and provides better user experience; moreover, the user can set timing information through sliding operations, compared to step-by-step adjustments through button operations.
  • the method and the method of directly inputting specific values greatly reduce the user's operation steps, making the setting of timing information faster and more convenient, and further improving the user's experience.

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Abstract

本申请提供了一种程控设备和植入式神经刺激系统，所述植入式神经刺激系统包括设置于患者体外的所述程控设备和植入于所述患者体内的刺激器；所述程控设备与所述刺激器可通信地连接，所述程控设备包括控制器；所述控制器被配置成：利用触摸屏接收滑动操作，响应于所述滑动操作，获取刺激程序的定时信息，所述刺激程序用于指示所述刺激器的刺激参数的标识和参数值，所述定时信息用于指示开始时刻和结束时刻；基于所述刺激程序及其的定时信息，生成控制指令并发送至所述刺激器，以使所述刺激器根据所述控制指令生成电刺激并向所述患者的目标组织施加所述电刺激。程控设备可以满足不同患者不同的剌激需求，适用范围广，用户使用体验较佳。

Description

程控设备和植入式神经刺激系统
本申请要求于2022年1月25日提交的申请号为202210089774.0的中国专利的优先权，上述中国专利通过全文引用的形式并入。
技术领域
本申请涉及植入式医疗设备技术领域，尤其涉及程控设备和植入式神经刺激系统。
背景技术
植入式神经刺激系统主要包括植入体内的刺激器以及体外的程控设备。神经调控技术主要是通过立体定向手术在体内特定结构(即靶点)植入电极，并由植入患者体内的刺激器经电极向靶点发放电脉冲，调控相应神经结构和网络的电活动及其功能，从而改善症状、缓解病痛。
现有的程控设备在定时剌激方面不够人性化，通常而言，刺激程序对应的刺激时间是由生产厂家设置好的，不可调整。例如：早上8点至晚上8点对应剌激脉冲幅值较大的刺激程序，其余时间自动切换至刺激脉冲幅值较小的刺激程序。
这种程控设备的缺陷是用户不能自主设置刺激程序所对应的刺激时间，不能满足不同患者不同的剌激需求，使用不灵活，用户体验较差。
发明内容
本申请的目的在于提供程控设备和植入式神经刺激系统，满足不同患者不同的剌激需求，适用范围广，用户使用体验较佳。
本申请的目的采用以下技术方案实现：
第一方面，本申请提供了一种程控设备，应用于植入式神经刺激系统，所述植入式神经刺激系统包括设置于患者体外的所述程控设备和植入于所述患者体内的刺激器；
所述程控设备与所述刺激器可通信地连接，所述程控设备包括控制器；
所述控制器被配置成：
利用触摸屏接收滑动操作，响应于所述滑动操作，获取刺激程序的定时信息，所述刺激程序用于指示所述刺激器的刺激参数的标识和参数值，所述定时信息用于指示开始时刻和结束时刻；
基于所述刺激程序及其的定时信息，生成控制指令并发送至所述刺激器，以 使所述刺激器根据所述控制指令生成电刺激并向所述患者的目标组织施加所述电刺激。
该技术方案的有益效果在于：一方面，用户可以灵活设置刺激程序对应的定时信息，相比于定时信息不可调节的程控设备，本申请的程控设备可以满足不同患者不同的剌激需求，适用范围广，用户使用体验较佳；另一方面，用户可以通过滑动操作设置定时信息，相比于通过按键操作逐步调节的方式和直接输入具体数值的方式，大大减少了用户的操作步骤，使得定时信息的设置更为快速便捷，进一步提升用户的使用体验。
在一种可能的实现方式中，所述控制器被配置成采用如下方式获取所述刺激程序的定时信息：
利用所述触摸屏接收所述滑动操作，响应于所述滑动操作，获取目标程控模式的定时信息，所述目标程控模式用于指示至少一个所述刺激程序；
基于所述目标程控模式及其定时信息，确定每个所述刺激程序的定时信息。
该技术方案的有益效果在于：目标程控模式可以指示一个或多个刺激程序，用户可以通过设置目标程控模式的定时信息以对多个刺激程序的定时信息同步设置，满足实际应用中不同患者的需要。
在一种可能的实现方式中，所述控制器被进一步配置成采用如下方式获取每个所述刺激程序的定时信息：
当所述目标程控模式指示单一的刺激程序时，确定所述目标程控模式的定时信息作为所述单一的刺激程序的定时信息；
当所述目标程控模式指示多个刺激程序时，基于所述目标程控模式的定时信息、每个所述刺激程序的持续时长和所述多个刺激程序的排序，确定每个所述刺激程序的定时信息。
该技术方案的有益效果在于：当目标程控模式指示单一的刺激程序时，在目标程控模式的定时信息对应的时间段内，提供的电刺激的形式是单一的；当目标程控模式指示多个刺激程序时，可以在目标程控模式的定时信息对应的时间段内，提供采用多个刺激程序按顺序进行的电刺激。
在一种可能的实现方式中，所述控制器还被配置成：
当所述目标程控模式的定时信息所对应的第一时间段和预先设置的已有程控模式的定时信息所对应的第二时间段有重合时，确定重合时间段；
当检测到所述重合时间段是所述第二时间段的部分时，从所述第二时间段中 去除所述重合时间段得到剩余时间段，利用所述剩余时间段更新所述已有程控模式的定时信息。
该技术方案的有益效果在于：当目标程控模式的定时信息和之前已经设置好的已有程控模式的定时信息有冲突时，以目标程控模式的定时信息为准，对已有程控模式的定时信息所对应的第二时间段进行去重，更新已有程控模式的定时信息，目标程控模式的定时信息不发生改变，能反映用户的调整意图，符合用户的使用偏好。
在一种可能的实现方式中，所述控制器还被配置成：
当检测到所述重合时间段是所述第二时间段的全部时，去除所述已有程控模式的定时信息。
该技术方案的有益效果在于：当重合时间段是第二时间段的全部时，可以去除已有程控模式的定时信息，第二时间段对应的程控模式从已有程控模式变为目标程控模式。
在一种可能的实现方式中，所述控制器还被配置成：
利用所述触摸屏显示表盘，并在所述表盘的周向显示可滑动的两个滑块，所述两个滑块的位置分别用于指示所述目标程控模式对应的开始时刻和结束时刻；
所述滑动操作是滑动一个滑块的操作或者滑动两个滑块的操作。
该技术方案的有益效果在于：通过设置表盘和滑块，开始时刻和结束时刻可以通过滑块在表盘上的位置清晰直观地反映出来，便于用户设置定时信息。
在一种可能的实现方式中，所述控制器被进一步配置成采用如下方式获取所述目标程控模式的定时信息：
分别检测滑动每个滑块的操作是否有效，以获取所述滑动操作中的有效操作；
基于所述有效操作，获取所述目标程控模式的定时信息。
该技术方案的有益效果在于：滑动操作可以是滑动一个滑块的操作，也可以是滑动两个滑块的操作，当用户滑动一个滑块，且滑动该滑块的操作被判定为有效时，根据该滑块的位置获取目标程控模式的定时信息；当用户滑动两个滑块时，只要滑动其中一个滑块或者两个滑块的操作被判定为有效，根据有效操作对应的滑块的位置获取目标程控模式的定时信息。
也就是说，不管滑动一个滑块还是滑动两个滑块，只要存在有效操作，就可以获取目标程控模式的定时信息，降低了用户定时设置的操作难度，对于手部控制能力较差的用户，尤其是帕金森患者，在滑动两个滑块时，即使只有滑动其中 一个滑块的操作被判定有效，也能设置定时信息，由此可以给到用户积极正面的反馈，大大减轻了用户的心理负担，提升用户的使用体验。
在一种可能的实现方式中，所述控制器被进一步配置成采用如下方式获取所述目标程控模式的定时信息：
分别检测滑动每个滑块的操作是否有效，当滑动每个滑块的操作均有效时，获取所述目标程控模式的定时信息。
该技术方案的有益效果在于：当用户滑动一个滑块，且滑动该滑块的操作被判定为有效时，根据该滑块的位置获取目标程控模式的定时信息；当用户滑动两个滑块时，只有滑动两个滑块的操作均被判定为有效，根据两个滑块的位置获取目标程控模式的定时信息。
也就是说，不管滑动一个滑块还是滑动两个滑块，只有被滑动的所有滑块对应的操作都有效时，才获取目标程控模式的定时信息，当用户滑动两个滑块，只有滑动其中一个滑块的操作被判定有效时，无法设置定时信息。对于抑郁症、躁郁症等患者而言，容易做出冲动、不理智的行为，本申请的程控设备在定时信息的设置上有一定的门槛，只有用户在理智、冷静的状态下的稳定操作才能设置定时信息，从而保障用户的生命安全，同时，对于儿童等无意使用程控设备的人员，只有被滑动的所有滑块对应的操作都有效时，才获取目标程控模式的定时信息，可以进一步避免误操作。
在一种可能的实现方式中，以被滑动的一个滑块作为目标滑块，检测滑动所述目标滑块的操作是否有效的过程如下：
基于滑动所述目标滑块的操作，获取所述目标滑块对应的滑动路径，检测所述滑动路径的各轨迹点的位置是否均处于预设滑动区域；
当所述滑动路径的至少一个轨迹点的位置不处于所述预设滑动区域时，确定滑动所述目标滑块的操作无效；
当所述滑动路径的各轨迹点的位置均处于所述预设滑动区域时，确定滑动所述目标滑块的操作有效。
该技术方案的有益效果在于：通过检测滑动路径的各轨迹点的位置来判断滑动目标滑块的操作是否有效，只有各轨迹点的位置均处于预设滑动区域时，才确定滑动所述目标滑块的操作有效，进而获取定时信息，由此可以避免用户误操作。
在一种可能的实现方式中，所述控制器被进一步配置成采用如下方式检测滑动所述目标滑块的操作是否有效：
当所述滑动路径的各轨迹点的位置均处于所述预设滑动区域时，基于所述滑动路径的起点、终点和路径方向，获取所述滑动路径对应的参考路径，所述参考路径是预设圆周路径的一部分且所述参考路径的路径方向由所述滑动路径的路径方向确定，所述预设圆周路径处于所述预设滑动区域；
检测所述滑动路径和所述参考路径的相似度是否不小于预设相似度阈值；
当所述相似度小于所述预设相似度阈值时，确定滑动所述目标滑块的操作无效；
当所述相似度不小于所述预设相似度阈值时，确定滑动所述目标滑块的操作有效。
该技术方案的有益效果在于：使用两个阶段的检测过程来判断滑动操作是否有效，只有判断滑动操作有效时才获取目标程控模式的定时信息，当第一阶段检测到滑动路径的各轨迹点的位置均处于预设滑动区域时，并非直接确定滑动操作有效，而是进入第二阶段的检测，当检测到相似度不小于预设相似度阈值时，才确定滑动操作有效，进而获取定时信息，两个阶段的检测过程可以起到双重保险的作用，避免用户因为误操作而设置不合理的定时信息，保障患者的生命安全。
具体而言，在第一阶段，检测所述滑动路径的各轨迹点的位置是否均处于预设滑动区域，当检测到所述滑动路径的各轨迹点的位置均处于预设滑动区域时，表明用户可能有设置定时信息的意图，这时进入第二阶段；在第二阶段，基于滑动路径的起点、终点和路径方向，获取滑动路径对应的参考路径，获取滑动路径和参考路径的相似度，检测相似度是否不小于预设相似度阈值，当相似度不小于预设相似度阈值时，可以确定滑动操作并非误操作，滑动操作有效。
通过两个阶段的检测过程得到有效性判断结果不是最终目的，其最终目的是根据有效性判断结果判断用户操作的真实意图，使得设置的定时信息符合用户心理预期，从而提升用户的使用体验。
在一种可能的实现方式中，所述控制器被进一步配置成采用如下方式获取所述参考路径：
在所述预设圆周路径上找到与所述滑动路径的起点距离最近的点，作为所述参考路径的起点；
在所述预设圆周路径上找到与所述滑动路径的终点距离最近的点，作为所述参考路径的终点；
基于所述滑动路径的路径方向，从所述预设圆周路径中取所述参考路径的起 点到终点之间的路径作为所述参考路径。
该技术方案的有益效果在于：以预设圆周路径上与滑动路径的起点距离最近的点作为参考路径的起点，以预设圆周路径上与滑动路径的终点距离最近的点作为参考路径的终点，截取预设圆周路径中沿滑动路径的路径方向从参考路径的起点到终点之间的路径作为参考路径，由此得到的参考路径较为贴合滑动路径，根据该参考路径获取对应的定时信息较为合理，能够真实反应用户在设置定时信息时的意图。
在一种可能的实现方式中，所述两个滑块包括用于指示开始时刻的开始滑块和用于指示结束时刻的结束滑块；
其中，以所述表盘的中心指向所述开始滑块的向量作为第一向量，以所述表盘的中心指向所述结束滑块的向量作为第二向量，所述第一向量沿所述表盘的顺时针方向到所述第二向量的夹角不超过180度。
该技术方案的有益效果在于：选取表盘的顺时针方向作为开始时刻到结束时刻的延伸方向，并且开始时刻到结束时刻对应的时间段不超过半个表盘对应的时间段。
例如：规定绕表盘一周的时间段为24小时，当两个滑块的位置对应的时刻依次为23：00和1：00时，确定23：00对应的滑块为开始滑块，1：00对应的滑块为结束滑块，由此确定的时间段为当天的23：00到次日的1：00(时长为2个小时)，而非当天的1：00到当天的23：00(时长为22个小时)，这种方式更符合用户的操作习惯。
在一种可能的实现方式中，所述控制器还被配置成：
利用所述触摸屏显示所述刺激器的时钟信息和所述程控设备的时钟信息；
利用所述触摸屏接收同步操作，响应于所述同步操作，对所述刺激器的时钟信息和所述程控设备的时钟信息进行同步处理。
该技术方案的有益效果在于：通过对刺激器的时钟信息和程控设备的时钟信息进行同步处理，可以避免刺激器和程控设备因为时钟信息不同步导致定时信息设置出现偏差。
在一种可能的实现方式中，所述控制器还被配置成：
获取疾病类型和预设时长之间的第一对应关系；
基于所述患者的疾病类型和所述第一对应关系，确定所述患者对应的预设时长；
当检测到所述目标程控模式的定时信息所对应的时长大于所述患者对应的预设时长时，提示用户重新操作。
该技术方案的有益效果在于：不同疾病类型的患者接受刺激所允许的时长不同，根据患者的疾病类型确定对应的预设时长，使定时信息时只能在对应的预设时长允许的范围内设置，保障患者的生命安全。
在一种可能的实现方式中，所述控制器还被配置成：
获取疾病类型和预设组织之间的第二对应关系；
基于所述患者的疾病类型和所述第二对应关系，获取所述患者的疾病类型对应的预设组织作为所述患者对应的目标组织。
该技术方案的有益效果在于：不同疾病类型的患者接受刺激的身体组织不同，根据患者的疾病类型确定对应的目标组织，从而针对性地向患者的目标组织施加电刺激，满足实际应用的需要。
在一种可能的实现方式中，所述刺激参数为电压的脉宽参数、幅值参数和频率参数中的一个或多个。
该技术方案的有益效果在于：目标参数可以是电压的脉宽参数、幅值参数和频率参数中的任意一个，使得程控设备可以基于目标参数的配置参数值控制刺激器向患者施加相应的电刺激，满足实际应用的需求。
在一种可能的实现方式中，所述患者的疾病类型包括癫痫、震颤、帕金森病、抑郁症、强迫症、阿尔茨海默症和药物成瘾症中的一个或多个。
该技术方案的有益效果在于：利用程控设备可以对疾病类型不同的患者体内的刺激器进行控制，适用范围较广。
在一种可能的实现方式中，所述程控设备还包括所述触摸屏和通信模块，所述控制器分别与所述触摸屏和所述通信模块电连接；
所述触摸屏被配置成接收用户的操作，所述通信模块被配置成实现所述程控设备与所述刺激器之间的数据交互。
该技术方案的有益效果在于：触摸屏和通信模块可以设置于程控设备上，使得程控设备具备人机交互功能和通信功能。
在一种可能的实现方式中，所述植入式神经刺激系统包括设置于患者体外的所述程控设备和植入于所述患者体内的刺激器；
所述刺激器被配置成生成电刺激并向所述患者的目标组织施加所述电刺激；
所述程控设备与所述刺激器可通信地连接，所述程控设备包括控制器：
所述控制器被配置成：
利用触摸屏接收滑动操作，响应于所述滑动操作，获取刺激程序的定时信息，所述刺激程序用于指示所述刺激器的刺激参数的标识和参数值，所述定时信息用于指示开始时刻和结束时刻；
基于所述刺激程序及其的定时信息，生成控制指令并发送至所述刺激器。
该技术方案的有益效果在于：植入式神经刺激系统可以满足不同患者不同的剌激需求，适用范围广，用户使用体验较佳；并且，用户可以通过滑动操作设置定时信息，相比于通过按键操作逐步调节的方式和直接输入具体数值的方式，大大减少了用户的操作步骤，使得定时信息的设置更为快速便捷，进一步提升用户的使用体验。
附图说明
下面结合附图和实施例对本申请进一步说明。
图1是本申请实施例提供的一种程控设备的控制方法的流程示意图；
图2是本申请实施例提供的一种获取刺激程序的定时信息的流程示意图；
图3是本申请实施例提供的一种程控设备的控制方法的部分流程示意图；
图4是本申请实施例提供的另一种程控设备的控制方法的部分流程示意图；
图5是本申请实施例提供的一种触摸屏的显示界面的示意图；
图6是本申请实施例提供的一种获取目标程控模式的定时信息的流程示意图；
图7是本申请实施例提供的一种检测滑动操作是否有效的流程示意图；
图8是本申请实施例提供的另一种检测滑动操作是否有效的流程示意图；
图9是本申请实施例提供的一种获取参考路径的流程示意图；
图10是本申请实施例提供的又一种获取目标参数的配置参数值的流程示意图；
图11是本申请实施例提供的一种程控设备的结构框图；
图12是本申请实施例提供的一种植入式神经刺激系统的结构框图。
具体实施方式
下面，结合附图以及具体实施方式，对本申请做进一步描述，需要说明的是，在不相冲突的前提下，以下描述的各实施例之间或各技术特征之间可以任意组合形成新的实施例。
在本申请中，“至少一个”是指一个或者多个，“多个”是指两个或两个以上。“和/或”，描述关联对象的关联关系，表示可以存在三种关系，例如，A和/或B，可以表示：单独存在A，同时存在A和B，单独存在B的情况，其中A，B可以是单数或者复数。字符“/”一般表示前后关联对象是一种“或”的关系。“以下至少一项(个)”或其类似表达，是指的这些项中的任意组合，包括单项(个)或复数项(个)的任意组合。例如，a，b或c中的至少一项(个)，可以表示：a，b，c，a和b，a和c，b和c或a和b和c，其中a、b和c可以是单个，也可以是多个。值得注意的是，“至少一项(个)”还可以解释成“一项(个)或多项(个)”。
本申请中，“示例性的”或者“例如”等词用于表示作例子、例证或说明。本申请中被描述为“示例性的”或者“例如”的任何实施例或设计方案不应被解释为比其他实施例或设计方案更优选或更具优势。确切而言，使用“示例性的”或者“例如”等词旨在以具体方式呈现相关概念。
下面，首先对本申请实施例的其中一个应用领域(即植入式神经刺激器)进行简单说明。
植入式神经刺激系统(一种植入式医疗系统)主要包括植入患者体内的刺激器(即植入式神经刺激器)以及设置于患者体外的程控设备。程控设备可以包括体外控制器，程控设备也可以就是体外控制器。现有的神经调控技术主要是通过立体定向手术在体内特定结构(即靶点)植入电极，并由植入患者体内的刺激器经电极向靶点发放电脉冲，调控相应神经结构和网络的电活动及其功能，从而改善症状、缓解病痛。其中，刺激器可以是植入式神经电刺激装置、植入式心脏电刺激系统(又称心脏起搏器)、植入式药物输注装置(Implantable Drug Delivery System，简称I DDS)和导线转接装置中的任意一种。植入式神经电刺激装置例如是脑深部电刺激系统(Deep Brain Stimulation，简称DBS)、植入式脑皮层刺激系统(Cortical Nerve Stimulation，简称CNS)、植入式脊髓电刺激系统(Spinal Cord Stimulation，简称SCS)、植入式骶神经电刺激系统(Sacral Nerve Stimulation，简称SNS)、植入式迷走神经电刺激系统(Vagus Nerve Stimulation，简称VNS)等。
刺激器可以包括IPG、延伸导线和电极导线，IPG(implantable pulse generator，植入式脉冲发生器)设置于患者体内，接收程控设备发送的程控指令，依 靠密封电池和电路向体内组织提供可控制的电刺激能量，通过植入的延伸导线和电极导线，为体内组织的特定区域递送一路或两路可控制的特定电刺激。延伸导线配合IPG使用，作为电刺激信号的传递媒体，将IPG产生的电刺激信号，传递给电极导线。电极导线通过多个电极触点，向体内组织的特定区域递送电刺激。刺激器设置有单侧或双侧的一路或多路电极导线，电极导线上设置有多个电极触点，电极触点可以均匀排列或者非均匀排列在电极导线的周向上。作为一个示例，电极触点可以以4行3列的阵列(共计12个电极触点)排列在电极导线的周向上。电极触点可以包括刺激电极触点和/或采集电极触点。电极触点例如可以采用片状、环状、点状等形状。
在一些可能的实施方式中，受刺激的体内组织可以是患者的脑组织，受刺激的部位可以是脑组织的特定部位。当患者的疾病类型不同时，受刺激的部位一般来说是不同的，所使用的刺激触点(单源或多源)的数量、一路或多路(单通道或多通道)特定电刺激信号的运用以及刺激参数数据也是不同的。本申请实施例对适用的疾病类型不做限定，其可以是脑深部刺激(DBS)、脊髓刺激(SCS)、骨盆刺激、胃刺激、外周神经刺激、功能性电刺激所适用的疾病类型。其中，DBS可以用于治疗或管理的疾病类型包括但不限于：痉挛疾病(例如，癫痫)、疼痛、偏头痛、精神疾病(例如，重度抑郁症(MDD))、躁郁症、焦虑症、创伤后压力心理障碍症、轻郁症、强迫症(OCD)、行为障碍、情绪障碍、记忆障碍、心理状态障碍、移动障碍(例如，特发性震颤或帕金森氏病)、亨廷顿病、阿尔茨海默症、药物成瘾症、孤独症或其他神经学或精神科疾病和损害。
本申请实施例中，程控设备和刺激器建立程控连接时，可以利用程控设备调整刺激器的刺激参数(不同的刺激参数所对应的电刺激信号不同)，也可以通过刺激器感测患者脑深部的生物电活动以采集得到电生理信号，并可以通过所采集到的电生理信号来继续调节刺激器的电刺激信号的刺激参数。
刺激参数可以包括：频率(例如是单位时间1s内的电刺激脉冲信号个数，单位为Hz)、脉宽(每个脉冲的持续时间，单位为μs)、幅值(一般用电压表述，即每个脉冲的强度，单位为V)、时序(例如可以是连续或者触发)、刺激模式(包括电流模式、电压模式、定时刺激模式和循环刺激模式中的一种或多种)、医生控制上限及下限(医生可调节的范围)和患者控制上限及下限(患者可自主调节 的范围)中的一种或多种。
在一个具体应用场景中，可以在电流模式或者电压模式下对刺激器的各刺激参数进行调节。
程控设备可以是医生程控设备(即医生使用的程控设备)或者患者程控设备(即患者使用的程控设备)。医生程控设备例如可以是搭载有程控软件的平板电脑、笔记本电脑、台式计算机、手机等智能终端设备。患者程控设备例如可以是搭载有程控软件的平板电脑、笔记本电脑、台式计算机、手机等智能终端设备，患者程控设备还可以是其他具有程控功能的电子设备(例如是具有程控功能的充电器、数据采集设备)。
本申请实施例对医生程控设备和刺激器的数据交互不进行限制，当医生远程程控时，医生程控设备可以通过服务器、患者程控设备与刺激器进行数据交互。当医生线下和患者面对面进行程控时，医生程控设备可以通过患者程控设备与刺激器进行数据交互，医生程控设备还可以直接与刺激器进行数据交互。
在一些可选的实施方式中，患者程控设备可以包括(与服务器通信的)主机和(与刺激器通信的)子机，主机和子机可通信的连接。其中，医生程控设备可以通过3G/4G/5G网络与服务器进行数据交互，服务器可以通过3G/4G/5G网络与主机进行数据交互，主机可以通过蓝牙协议/WIFI协议/USB协议与子机进行数据交互，子机可以通过401MHz-406MHz工作频段/2.4GHz-2.48GHz工作频段与刺激器进行数据交互，医生程控设备可以通过401MHz-406MHz工作频段/2.4GHz-2.48GHz工作频段与刺激器直接进行数据交互。
参见图1，本申请实施例提供了一种程控设备的控制方法，应用于植入式神经刺激系统，所述植入式神经刺激系统包括设置于患者体外的所述程控设备和植入于所述患者体内的刺激器；
所述程控设备与所述刺激器可通信地连接。
所述方法包括步骤S101～步骤S102。
步骤S101：利用触摸屏接收滑动操作，响应于所述滑动操作，获取刺激程序的定时信息，所述刺激程序用于指示所述刺激器的刺激参数的标识和参数值，所述定时信息用于指示开始时刻和结束时刻；
步骤S102：基于所述刺激程序及其的定时信息，生成控制指令并发送至所述刺激器，以使所述刺激器根据所述控制指令生成电刺激并向所述患者的目标组 织施加所述电刺激。
在一些实施方式中，获取刺激程序的定时信息可以是对没有设置过定时信息的刺激程序(例如新增的刺激程序)进行定时信息的设置。
在另一些实施方式中，获取刺激程序的定时信息可以是对已经设置过定时信息的刺激程序进行定时信息的修改。在一些实施方式中，刺激程序的刺激参数可以随时进行调节，可以(利用触摸屏)设置或者修改刺激程序对应的刺激参数的参数值。
由此，一方面，用户可以灵活设置刺激程序对应的定时信息，相比于定时信息不可调节的程控设备，本申请的程控设备可以满足不同患者不同的剌激需求，适用范围广，用户使用体验较佳；另一方面，用户可以通过滑动操作设置定时信息，相比于通过按键操作逐步调节的方式和直接输入具体数值的方式，大大减少了用户的操作步骤，使得定时信息的设置更为快速便捷，进一步提升用户的使用体验。
刺激器可以是植入式神经电刺激装置、植入式心脏电刺激系统(又称心脏起搏器)、植入式药物输注装置(Implantable Drug Delivery System，简称I DDS)和导线转接装置中的任意一种。植入式神经电刺激装置例如是脑深部电刺激系统(Deep Brain Stimulation，简称DBS)，植入式脑皮层刺激系统(Cortical Nerve Stimulation，简称CNS)，植入式脊髓电刺激系统(Spinal Cord Stimulation，简称SCS)，植入式骶神经电刺激系统(Sacral Nerve Stimulation，简称SNS)，植入式迷走神经电刺激系统(Vagus Nerve Stimulation，简称VNS)等。刺激器设置于患者体内，用于提供电刺激。
程控设备可以包括但不限于：智能手机(如Android手机、iOS手机等)、平板电脑、便携式个人计算机、移动互联网设备(Mobile Internet Devices，MID)等设备，本申请实施例不做限定。
在一种可能的实现方式中，所述程控设备还可以包括所述触摸屏和通信模块。
所述触摸屏被配置成接收用户的操作，所述通信模块被配置成实现所述程控设备与所述刺激器之间的数据交互。
由此，触摸屏和通信模块可以设置于程控设备上，使得程控设备具备人机交互功能和通信功能。
在一些实施方式中，程控设备可以包括医生程控设备和/或患者程控设备。
患者程控设备是为患者配备的，患者可以利用患者程控设备自行调节对应的 刺激器的刺激参数。具体地，可以基于患者的疾病信息设置对应的预设调节范围，患者只能在对应的预设调节范围内调节对应的刺激器的刺激参数。
医生程控设备是为医生配备的，一个医生程控设备可以利用通信模块分别与多个患者的刺激器进行数据交互。
在一些实施方式中，通信模块可以包括有线通信模块和/或无线通信模块。
有线通信模块可以包括光纤通信单元、同轴电缆通信单元、明线通信单元、波导通信单元和光电通信单元中的一个或多个；无线通信模块可以包括4G通信单元、5G通信单元、WIFI通信单元、近场通信单元、WiGig通信单元、蓝牙通信单元、ZigBee通信单元、微波通信单元、卫星通信单元和大气激光通信单元中的一个或多个。
有线通信模块较为稳定，且可靠性高、传输速率高；无线通信模块的通信距离更长，且不受线的限制，具有一定的移动性，可以在移动状态下通过无线连接进行通信，成本较低。
在一些实施方式中，触摸屏可以包括电阻式触摸屏、电容式触摸屏和表面声波屏中的任意一个。
在一种可能的实现方式中，所述刺激参数可以为电压的脉宽参数、幅值参数和频率参数中的一个或多个。
由此，目标参数可以是电压的脉宽参数、幅值参数和频率参数中的任意一个，使得程控设备可以基于目标参数的配置参数值控制刺激器向患者施加相应的电刺激，满足实际应用的需求。
在一些实施方式中，刺激参数还可以包括刺激模式、能量输出方式中的一个或多个。
刺激模式用于指示单极刺激或者多极刺激，能量输出方式用于指示恒压刺激或者恒流刺激。
恒压刺激即输出的电压固定不变，电流随电阻的变化而变化；恒流刺激即输出的电流固定不变，电压随电阻的变化而变化。
参见图2，在一种可能的实现方式中，所述步骤S101可以包括步骤S201～步骤S202。
步骤S201：利用所述触摸屏接收所述滑动操作，响应于所述滑动操作，获取目标程控模式的定时信息，所述目标程控模式用于指示至少一个所述刺激程序；
步骤S202：基于所述目标程控模式及其定时信息，确定每个所述刺激程序 的定时信息。
本申请对目标程控模式所指示的刺激程序的数量不做限定，其可以是1个、3个、6个或者8个。
由此，目标程控模式可以指示一个或多个刺激程序，用户可以通过设置目标程控模式的定时信息以对多个刺激程序的定时信息同步设置，满足实际应用中不同患者的需要。
在一具体应用中，目标程控模式指示刺激程序a，刺激程序a指示：脉宽60μs、幅值0.2V、频率80Hz，目标程控模式的定时信息例如是：12：00至15：00，因此可以确定刺激程序a的定时信息为12：00至15：00，则在12：00至15：00，为患者施加刺激程序a对应的电刺激。
在另一具体应用中，当目标程控模式指示多个刺激程序时，对目标程控模式的定时信息采用平均分配或者按预设比例分配的方式，确定每个刺激程序的定时信息。
例如：目标程控模式按顺序依次指示刺激程序b、刺激程序c和刺激程序d。目标程控模式的定时信息为15：00至16：00，则刺激程序b的定时信息为15：00至15：20，刺激程序c的定时信息为15：20至15：40；刺激程序d的定时信息为15：40至16：00。
在一种可能的实现方式中，所述步骤S202可以包括：
当所述目标程控模式指示单一的刺激程序时，确定所述目标程控模式的定时信息作为所述单一的刺激程序的定时信息；
当所述目标程控模式指示多个刺激程序时，基于所述目标程控模式的定时信息、每个所述刺激程序的持续时长和所述多个刺激程序的排序，确定每个所述刺激程序的定时信息。
由此，当目标程控模式指示单一的刺激程序时，在目标程控模式的定时信息对应的时间段内，提供的电刺激的形式是单一的；当目标程控模式指示多个刺激程序时，可以在目标程控模式的定时信息对应的时间段内，提供采用多个刺激程序按顺序进行的电刺激。
在一具体应用中，目标程控模式按顺序依次指示刺激程序e、刺激程序f和刺激程序g。刺激程序e的持续时长为120s，刺激程序f的持续时长为90s，刺激程序g的持续时长为150s，目标程控模式的刺激周期为120s+90s+150s＝360s。
目标程控模式的定时信息为15：00至16：00，则在15：00至16：00，可 以为患者施加循环10个刺激周期的电刺激，在每个刺激周期内(0至360s)，刺激程序e的定时信息为0至120s，刺激程序f的定时信息为120至210s，刺激程序g的定时信息为210至360s。
在一具体应用中，无刺激(即刺激参数的参数值为零)也可以作为一种刺激方式，其形式例如是刺激程序轮空。
例如：目标程控模式按顺序依次指示刺激程序h、刺激程序j和刺激程序轮空。
参见图3，在一种可能的实现方式中，所述方法还可以包括步骤S301～步骤S302。
步骤S301：当所述目标程控模式的定时信息所对应的第一时间段和预先设置的已有程控模式的定时信息所对应的第二时间段有重合时，确定重合时间段；
步骤S302：当检测到所述重合时间段是所述第二时间段的部分时，从所述第二时间段中去除所述重合时间段得到剩余时间段，利用所述剩余时间段更新所述已有程控模式的定时信息。
由此，当目标程控模式的定时信息和之前已经设置好的已有程控模式的定时信息有冲突时，以目标程控模式的定时信息为准，对已有程控模式的定时信息所对应的第二时间段进行去重，更新已有程控模式的定时信息，目标程控模式的定时信息不发生改变(维持用户的设置结果)，能反映用户的调整意图，符合用户的使用偏好。
在一具体应用中，目标程控模式的定时信息对应的第一时间段为2：00至5：00，已有程控模式的定时信息所对应的第二时间段为4：00至7：00，重合时间段为4：00至5：00，重合时间段是第二时间段的部分，第二时间段去除重合时间段后，得到剩余时间段5：00至7：00，利用剩余时间段更新已有程控模式的定时信息，使得已有程控模式的定时信息指示5：00至7：00。
参见图4，在一种可能的实现方式中，所述方法还可以包括步骤S303。
步骤S303：当检测到所述重合时间段是所述第二时间段的全部时，去除所述已有程控模式的定时信息。
由此，当重合时间段是第二时间段的全部时，可以去除已有程控模式的定时信息，第二时间段对应的程控模式从已有程控模式变为目标程控模式。
在一具体应用中，目标程控模式的定时信息对应的第一时间段为2：00至5：00，已有程控模式的定时信息所对应的第二时间段为4：00至5：00，重合时间 段为4：00至5：00，重合时间段是第二时间段的全部，去除已有程控模式的定时信息。
在一些实施方式中，当检测到重合时间段是第二时间段的全部时，可以(以延后等形式)调整已有程控模式的定时信息，以使所述第一时间段与调整后的第二时间段不重合。在这种情况中，已有程控模式的定时时长不变。
在一具体应用中，目标程控模式的定时信息对应的第一时间段为2：00至5：00，已有程控模式的定时信息所对应的第二时间段为4：00至5：00，重合时间段为4：00至5：00，重合时间段是第二时间段的全部，则调整已有程控模式的定时信息，调整后，第二时间段为5：00至7：00。
在一种可能的实现方式中，所述方法还可以包括：
利用所述触摸屏显示表盘，并在所述表盘的周向显示可滑动的两个滑块，所述两个滑块的位置分别用于指示所述目标程控模式对应的开始时刻和结束时刻；
所述滑动操作是滑动一个滑块的操作或者滑动两个滑块的操作。
由此，通过设置表盘和滑块，开始时刻和结束时刻可以通过滑块在表盘上的位置清晰直观地反映出来，便于用户设置定时信息。
本申请对滑块的形状不作限定，滑块的形状可以是圆形、三角形、矩形、多边形中的任意一种。
参见图5，在一具体应用中，表盘一周表示的时间跨度可以是6小时、8小时、12小时或者24小时。
表盘的周向可以设置有多个刻度，例如：沿表盘的顺时针方向可以设置有4个刻度，这4个刻度表示的时刻依次为0：00(24：00)、6：00、12：00和18：00。
在一些实施方式中，所述表盘沿顺时针方向依次设置有N个刻度，第k个刻度对应的时刻和第k-1个刻度对应的时刻之间的差值与第k+1个刻度对应的时刻和第k个刻度对应的时刻之间的差值不同。N为大于2的整数，k为大于1小于N的整数。
例如：表盘沿顺时针方向依次设置有6个刻度，这6个刻度表示的时刻依次为0：00、8：00、14：00、19：00、21：00和23：00。
在一些实施方式中，所述两个滑块可以包括用于指示开始时刻的开始滑块和用于指示结束时刻的结束滑块，其中，开始时刻与结束时刻的设定范围为同一天的0：00至23：59(或者0：00：00至23：59：59)，并且开始滑块与结束滑 块所对应的滑块是恒定的，不会因为用户的滑动操作变化。
在一具体应用中，开始滑块和结束滑块可以采用同种颜色和/或同种形状进行显示。
在另一具体应用中，开始滑块和结束滑块可以分别采用不同的颜色和/或不同的形状进行显示。
例如，开始滑块在触摸屏上显示为蓝色的滑块a，结束滑块在触摸屏上显示为黄色的滑块b，滑块a的位置对应的时刻为8：00，滑块b对应的时刻为22：00，则开始时刻为当天的8：00，结束时刻为当天的22：00。
例如可以采用绿色显示目标程控模式的定时信息对应的(径向上有一定宽度的)圆弧区域，该圆弧区域的一端以目标程控模式的开始时刻对应的位置为起点，另一端以目标程控模式的结束时刻对应的位置为终点，由起点指向终点，由此直观地显示目标程控模式的定时信息所对应的时间段。
在一些实施方式中，当一个程控模式的定时信息设置完成后，该程控模式的定时信息即为预先设置的已有程控模式的定时信息。
例如可以采用红色显示已有程控模式的定时信息对应的(径向上有一定宽度的)圆弧区域，该圆弧区域的一端以已有程控模式的开始时刻对应的位置为起点，另一端以已有程控模式的结束时刻对应的位置为终点，由起点指向终点，由此直观地显示已有程控模式的定时信息所对应的时间段，提示用户该圆弧区域对应的时间段有相对应的已有程控模式。
参见图6，在一种可能的实现方式中，所述步骤S201可以包括步骤S401～步骤S402。
步骤S401：分别检测滑动每个滑块的操作是否有效，以获取所述滑动操作中的有效操作；
步骤S402：基于所述有效操作，获取所述目标程控模式的定时信息。
由此，滑动操作可以是滑动一个滑块的操作，也可以是滑动两个滑块的操作，当用户滑动一个滑块，且滑动该滑块的操作被判定为有效时，根据该滑块的位置获取目标程控模式的定时信息；当用户滑动两个滑块时，只要滑动其中一个滑块或者两个滑块的操作被判定为有效，根据有效操作对应的滑块的位置获取目标程控模式的定时信息。
也就是说，不管滑动一个滑块还是滑动两个滑块，只要存在有效操作，就可以获取目标程控模式的定时信息，降低了用户定时设置的操作难度，对于手部控 制能力较差的用户，尤其是帕金森患者，在滑动两个滑块时，即使只有滑动其中一个滑块的操作被判定有效，也能设置定时信息，由此可以给到用户积极正面的反馈，大大减轻了用户的心理负担，提升用户的使用体验。
在一种可能的实现方式中，所述步骤S201可以包括：
分别检测滑动每个滑块的操作是否有效，当滑动每个滑块的操作均有效时，获取所述目标程控模式的定时信息。
由此，当用户滑动一个滑块，且滑动该滑块的操作被判定为有效时，根据该滑块的位置获取目标程控模式的定时信息；当用户滑动两个滑块时，只有滑动两个滑块的操作均被判定为有效，根据两个滑块的位置获取目标程控模式的定时信息。
也就是说，不管滑动一个滑块还是滑动两个滑块，只有被滑动的所有滑块对应的操作都有效时，才获取目标程控模式的定时信息，当用户滑动两个滑块，只有滑动其中一个滑块的操作被判定有效时，无法设置定时信息。对于抑郁症、躁郁症等患者而言，容易做出冲动、不理智的行为，本申请的程控设备在定时信息的设置上有一定的操作门槛，只有用户在理智、冷静的状态下的稳定操作才能设置定时信息，从而保障用户的生命安全，同时，对于儿童等无意使用程控设备的人员，只有被滑动的所有滑块对应的操作都有效时，才获取目标程控模式的定时信息，可以进一步避免误操作。
本申请的程控设备通过简单的滑动操作即可设置定时信息，就使用程控设备的医生而言，提升了设置效率，同时，还考虑到了使用该程控设备的患者，先判断操作是否有效，再据此设置定时信息，由此做到了以人为本，体现了人性化关怀。
参见图7，在一种可能的实现方式中，以被滑动的一个滑块作为目标滑块，检测滑动所述目标滑块的操作是否有效的过程可以包括步骤S501～步骤S503。
步骤S501：基于滑动所述目标滑块的操作，获取所述目标滑块对应的滑动路径，检测所述滑动路径的各轨迹点的位置是否均处于预设滑动区域；
步骤S502：当所述滑动路径的至少一个轨迹点的位置不处于所述预设滑动区域时，确定滑动所述目标滑块的操作无效；
步骤S503：当所述滑动路径的各轨迹点的位置均处于所述预设滑动区域时，确定滑动所述目标滑块的操作有效。
由此，通过检测滑动路径的各轨迹点的位置来判断滑动目标滑块的操作是否 有效，只有各轨迹点的位置均处于预设滑动区域时，才确定滑动所述目标滑块的操作有效，进而获取定时信息，由此可以避免用户误操作。
参见图8，在一种可能的实现方式中，检测滑动所述目标滑块的操作是否有效的过程可以包括步骤S601～步骤S604。
步骤S601：当所述滑动路径的各轨迹点的位置均处于所述预设滑动区域时，基于所述滑动路径的起点、终点和路径方向，获取所述滑动路径对应的参考路径，所述参考路径是预设圆周路径的一部分且所述参考路径的路径方向由所述滑动路径的路径方向确定，所述预设圆周路径处于所述预设滑动区域；
步骤S602：检测所述滑动路径和所述参考路径的相似度是否不小于预设相似度阈值；
步骤S603：当所述相似度小于所述预设相似度阈值时，确定滑动所述目标滑块的操作无效；
步骤S604：当所述相似度不小于所述预设相似度阈值时，确定滑动所述目标滑块的操作有效。
在一些实施方式中，预设滑动区域的形状可以是与预设圆周路径同心的圆环。
由此，使用两个阶段的检测过程来判断滑动操作是否有效，只有判断滑动操作有效时才获取目标程控模式的定时信息，当第一阶段检测到滑动路径的各轨迹点的位置均处于预设滑动区域时，并非直接确定滑动操作有效，而是进入第二阶段的检测，当检测到相似度不小于预设相似度阈值时，才确定滑动操作有效，进而获取定时信息，两个阶段的检测过程可以起到双重保险的作用，避免用户因为误操作而设置不合理的定时信息，保障患者的生命安全。
具体而言，在第一阶段，检测所述滑动路径的各轨迹点的位置是否均处于预设滑动区域，当检测到所述滑动路径的各轨迹点的位置均处于预设滑动区域时，表明用户可能有设置定时信息的意图，这时进入第二阶段；在第二阶段，基于滑动路径的起点、终点和路径方向，获取滑动路径对应的参考路径，获取滑动路径和参考路径的相似度，检测相似度是否不小于预设相似度阈值，当相似度不小于预设相似度阈值时，可以确定滑动操作并非误操作，滑动操作有效。
通过两个阶段的检测过程得到有效性判断结果不是最终目的，其最终目的是根据有效性判断结果判断用户操作的真实意图，使得设置的定时信息符合用户心理预期，从而提升用户的使用体验。
在一些实施方式中，所述滑动路径和所述参考路径的相似度可以采用如下方 式获取：
获取多个相似度训练数据，每个所述相似度训练数据包括用于训练的样本滑动路径、样本参考路径以及二者的标注相似度；
利用多个所述相似度训练数据训练预设的深度学习模型，得到相似度模型；
将所述滑动路径和所述参考路径输入所述相似度模型，得到所述相似度。
由此，可以根据相似度训练数据训练预设的深度学习模型，得到相似度模型，只需将滑动路径和参考路径输入相似度模型，即可实时地自动生成对应的相似度，智能化程度较高。通过设计，建立适量的神经元计算节点和多层运算层次结构，选择合适的输入层和输出层，就可以得到预设的深度学习模型，通过该预设的深度学习模型的学习和调优，建立起从输入到输出的函数关系，虽然不能100％找到输入与输出的函数关系，但是可以尽可能地逼近现实的关联关系，由此训练得到的相似度模型，可以实时输出对应的相似度，且输出结果可靠性高。
在一些实施方式中，所述预设相似度阈值可以采用如下方式获取：
获取疾病类型和相似度阈值之间的第三对应关系；
基于所述患者的疾病类型和所述第三对应关系，获取所述患者的疾病类型对应的相似度阈值作为所述预设相似度阈值。
由此，疾病类型不同的患者的手部控制的能力可能不同，相比于手部控制力强的患者，手部控制力较差的帕金森患者在滑动时滑动路径与预设圆周路径的偏差可能较大，相似度可能较低，针对不同疾病类型的患者，采用不同的预设相似度阈值，使得程控设备可以支持手部控制力较差的患者进行滑动操作，大大降低了患者在使用程控设备时的操作难度。
在一具体应用中，帕金森病对应的相似度阈值为60％，抑郁症对应的相似度阈值为80％，药物成瘾症对应的相似度阈值为85％。
例如患者张三为帕金森患者，则张三的预设相似度阈值为60％。当患者的疾病类型大于一种时，可以以该患者所有疾病类型对应的相似度阈值中最低的一个作为该患者的预设相似度阈值，或者可以以该患者所有疾病类型对应的相似度阈值中最高的一个作为该患者的预设相似度阈值。
参见图9，在一种可能的实现方式中，可以采用步骤S701～步骤S703获取所述参考路径：
步骤S701：在所述预设圆周路径上找到与所述滑动路径的起点距离最近的点，作为所述参考路径的起点；
步骤S702：在所述预设圆周路径上找到与所述滑动路径的终点距离最近的点，作为所述参考路径的终点；
步骤S703：基于所述滑动路径的路径方向，从所述预设圆周路径中取所述参考路径的起点到终点之间的路径作为所述参考路径。
由此，以预设圆周路径上与滑动路径的起点距离最近的点作为参考路径的起点，以预设圆周路径上与滑动路径的终点距离最近的点作为参考路径的终点，截取预设圆周路径中沿滑动路径的路径方向从参考路径的起点到终点之间的路径作为参考路径，由此得到的参考路径较为贴合滑动路径，根据该参考路径获取对应的定时信息较为合理，能够真实反应用户在设置定时信息时的意图。
在一种可能的实现方式中，所述两个滑块包括用于指示开始时刻的开始滑块和用于指示结束时刻的结束滑块；
其中，以所述表盘的中心指向所述开始滑块的向量作为第一向量，以所述表盘的中心指向所述结束滑块的向量作为第二向量，所述第一向量沿所述表盘的顺时针方向到所述第二向量的夹角不超过180度。
由此，选取表盘的顺时针方向作为开始时刻到结束时刻的延伸方向，并且开始时刻到结束时刻对应的时间段不超过半个表盘对应的时间段。
例如：规定绕表盘一周的时间段为24小时(即采用24小时制)，当两个滑块的位置对应的时刻依次为23：00和1：00时，确定23：00对应的滑块为开始滑块，1：00对应的滑块为结束滑块，由此确定的时间段为当天的23：00到次日的1：00(时长为2个小时)，而非当天的1：00到当天的23：00(时长为22个小时)，这种方式更符合用户的操作习惯。
在一具体应用中，两个滑块的位置对应的时刻依次为5：00和15：00，确定5：00对应的滑块为开始滑块，15：00对应的滑块为结束滑块，由此确定的时间段为当天的5：00到15：00(时长为10个小时)。
这种方式下，开始滑块与结束滑块所对应的滑块不是恒定的，两个滑块的具体分配情况由用户的滑动操作确定。
例如，两个滑块分别为滑块c和滑块d，当滑块c的位置对应的时刻为23：00，滑块d的位置对应的时刻为1：00时，滑块c为开始滑块，滑块d为结束滑块；而当滑块c的位置对应的时刻为15：00，滑块d的位置对应的时刻为5：00时，滑块c为结束滑块，滑块d为开始滑块。
参见图10，在一种可能的实现方式中，所述方法还可以包括步骤S801～步骤 S802。
步骤S801：利用所述触摸屏显示所述刺激器的时钟信息和所述程控设备的时钟信息；
步骤S802：利用所述触摸屏接收同步操作，响应于所述同步操作，对所述刺激器的时钟信息和所述程控设备的时钟信息进行同步处理。
由此，通过对刺激器的时钟信息和程控设备的时钟信息进行同步处理，可以避免刺激器和程控设备因为时钟信息不同步导致定时信息设置出现偏差。
在一具体应用中，刺激器的时钟信息指示16：47：20，程控设备的时钟信息指示16：40：20，对刺激器的时钟信息和程控设备的时钟信息进行同步处理，使得刺激器的时钟信息和程控设备的时钟信息同步，为16：40：20。
在一种可能的实现方式中，所述方法还可以包括：
获取疾病类型和预设时长之间的第一对应关系；
基于所述患者的疾病类型和所述第一对应关系，确定所述患者对应的预设时长；
当检测到所述目标程控模式的定时信息所对应的时长大于所述患者对应的预设时长时，提示用户重新操作。
由此，不同疾病类型的患者接受刺激所允许的时长不同，根据患者的疾病类型确定对应的预设时长，使定时信息时只能在对应的预设时长允许的范围内设置，保障患者的生命安全。
在一具体应用中，帕金森病对应的预设时长为8小时，抑郁症对应的预设时长为3小时，药物成瘾症对应的预设时长为7小时。
例如患者张三为帕金森患者，则张三的预设时长为8小时。当患者的疾病类型大于一种时，可以以该患者所有疾病类型对应的预设时长中最短的一个作为该患者的预设时长。
在一种可能的实现方式中，所述方法还可以包括：
获取疾病类型和预设组织之间的第二对应关系；
基于所述患者的疾病类型和所述第二对应关系，获取所述患者的疾病类型对应的预设组织作为所述患者对应的目标组织。
预设组织可以是脑组织，预设组织可以包括丘脑底核、内侧苍白球、丘脑腹中间核、左内囊前肢、左伏隔核、右内囊前肢和右伏隔核中的一个或多个。在一些具体应用中，预设组织可以是多个脑细胞形成的脑组织。在另一些具体应用中， 预设组织也可以是单个脑细胞。
由此，不同疾病类型的患者接受刺激的身体组织不同，根据患者的疾病类型确定对应的目标组织，从而针对性地向患者的目标组织施加电刺激，满足实际应用的需要。
本申请的程控设备对适用的疾病类型不做限定，疾病类型包括但不限于：痉挛疾病(例如，癫痫)、疼痛、偏头痛、精神疾病(例如，重度抑郁症(MDD))、躁郁症、焦虑症、创伤后压力心理障碍症、轻郁症、强迫症(OCD)、行为障碍、情绪障碍、记忆障碍、心理状态障碍、移动障碍(例如，震颤或帕金森病)、亨廷顿病、阿尔茨海默症、药物成瘾症或其他神经学或精神科疾病和损害。当程控设备用于治疗药物成瘾症患者时，可以帮助吸毒人员戒毒，提升他们的幸福感和生命质量。
在一种可能的实现方式中，所述患者的疾病类型包括癫痫、震颤、帕金森病、抑郁症、强迫症、阿尔茨海默症和药物成瘾症中的一个或多个。
由此，利用程控设备可以对疾病类型不同的患者体内的刺激器进行控制，适用范围较广。
参见图11，本申请还提供了一种程控设备100，其具体实现方式与上述控制方法的实施例中记载的实施方式、所达到的技术效果一致，部分内容不再赘述。
所述程控设备100应用于植入式神经刺激系统，所述植入式神经刺激系统包括设置于患者体外的所述程控设备100和植入于所述患者体内的刺激器；
所述程控设备100与所述刺激器可通信地连接，所述程控设备100包括控制器103；
所述控制器103被配置成：
利用触摸屏101接收滑动操作，响应于所述滑动操作，获取刺激程序的定时信息，所述刺激程序用于指示所述刺激器的刺激参数的标识和参数值，所述定时信息用于指示开始时刻和结束时刻；
基于所述刺激程序及其的定时信息，生成控制指令并发送至所述刺激器，以使所述刺激器根据所述控制指令生成电刺激并向所述患者的目标组织施加所述电刺激。
在一些实施方式中，控制器103可以包括至少一个存储器、至少一个处理器以及连接不同平台系统的总线。其中，存储器可以包括随机存取存储器(RAM)、只读存储器(ROM)和高速缓存存储器中的一个或多个。存储器存储有计算机程序， 该计算机程序可以被处理器执行。总线可以为表示几类总线结构中的一种或多种，包括存储器总线、外围总线、图形加速端口或者使用多种总线结构中的任意总线结构的局域总线。
在一种可能的实现方式中，所述控制器103被配置成采用如下方式获取所述刺激程序的定时信息：
利用所述触摸屏101接收所述滑动操作，响应于所述滑动操作，获取目标程控模式的定时信息，所述目标程控模式用于指示至少一个所述刺激程序；
基于所述目标程控模式及其定时信息，确定每个所述刺激程序的定时信息。
在一种可能的实现方式中，所述控制器103被进一步配置成采用如下方式获取每个所述刺激程序的定时信息：
当所述目标程控模式指示单一的刺激程序时，确定所述目标程控模式的定时信息作为所述单一的刺激程序的定时信息；
当所述目标程控模式指示多个刺激程序时，基于所述目标程控模式的定时信息、每个所述刺激程序的持续时长和所述多个刺激程序的排序，确定每个所述刺激程序的定时信息。
在一种可能的实现方式中，所述控制器103还被配置成：
当所述目标程控模式的定时信息所对应的第一时间段和预先设置的已有程控模式的定时信息所对应的第二时间段有重合时，确定重合时间段；
当检测到所述重合时间段是所述第二时间段的部分时，从所述第二时间段中去除所述重合时间段得到剩余时间段，利用所述剩余时间段更新所述已有程控模式的定时信息。
在一种可能的实现方式中，所述控制器103还被配置成：
当检测到所述重合时间段是所述第二时间段的全部时，去除所述已有程控模式的定时信息。
在一种可能的实现方式中，所述控制器103还被配置成：
利用所述触摸屏101显示表盘，并在所述表盘的周向显示可滑动的两个滑块，所述两个滑块的位置分别用于指示所述目标程控模式对应的开始时刻和结束时刻；
所述滑动操作是滑动一个滑块的操作或者滑动两个滑块的操作。
在一种可能的实现方式中，所述控制器103被进一步配置成采用如下方式获取所述目标程控模式的定时信息：
分别检测滑动每个滑块的操作是否有效，以获取所述滑动操作中的有效操作；
基于所述有效操作，获取所述目标程控模式的定时信息。
在一种可能的实现方式中，所述控制器103被进一步配置成采用如下方式获取所述目标程控模式的定时信息：
分别检测滑动每个滑块的操作是否有效，当滑动每个滑块的操作均有效时，获取所述目标程控模式的定时信息。
在一种可能的实现方式中，以被滑动的一个滑块作为目标滑块，检测滑动所述目标滑块的操作是否有效的过程如下：
基于滑动所述目标滑块的操作，获取所述目标滑块对应的滑动路径，检测所述滑动路径的各轨迹点的位置是否均处于预设滑动区域；
当所述滑动路径的至少一个轨迹点的位置不处于所述预设滑动区域时，确定滑动所述目标滑块的操作无效；
当所述滑动路径的各轨迹点的位置均处于所述预设滑动区域时，确定滑动所述目标滑块的操作有效。
在一种可能的实现方式中，所述控制器103被进一步配置成采用如下方式检测滑动所述目标滑块的操作是否有效：
当所述滑动路径的各轨迹点的位置均处于所述预设滑动区域时，基于所述滑动路径的起点、终点和路径方向，获取所述滑动路径对应的参考路径，所述参考路径是预设圆周路径的一部分且所述参考路径的路径方向由所述滑动路径的路径方向确定，所述预设圆周路径处于所述预设滑动区域；
检测所述滑动路径和所述参考路径的相似度是否不小于预设相似度阈值；
当所述相似度小于所述预设相似度阈值时，确定滑动所述目标滑块的操作无效；
当所述相似度不小于所述预设相似度阈值时，确定滑动所述目标滑块的操作有效。
在一种可能的实现方式中，所述控制器103被进一步配置成采用如下方式获取所述参考路径：
在所述预设圆周路径上找到与所述滑动路径的起点距离最近的点，作为所述参考路径的起点；
在所述预设圆周路径上找到与所述滑动路径的终点距离最近的点，作为所述参考路径的终点；
基于所述滑动路径的路径方向，从所述预设圆周路径中取所述参考路径的起点到终点之间的路径作为所述参考路径。
在一种可能的实现方式中，所述两个滑块包括用于指示开始时刻的开始滑块和用于指示结束时刻的结束滑块；
其中，以所述表盘的中心指向所述开始滑块的向量作为第一向量，以所述表盘的中心指向所述结束滑块的向量作为第二向量，所述第一向量沿所述表盘的顺时针方向到所述第二向量的夹角不超过180度。
在一种可能的实现方式中，所述控制器103还被配置成：
利用所述触摸屏101显示所述刺激器的时钟信息和所述程控设备100的时钟信息；
利用所述触摸屏101接收同步操作，响应于所述同步操作，对所述刺激器的时钟信息和所述程控设备100的时钟信息进行同步处理。
在一种可能的实现方式中，所述控制器103还被配置成：
获取疾病类型和预设时长之间的第一对应关系；
基于所述患者的疾病类型和所述第一对应关系，确定所述患者对应的预设时长；
当检测到所述目标程控模式的定时信息所对应的时长大于所述患者对应的预设时长时，提示用户重新操作。
在一种可能的实现方式中，所述控制器103还被配置成：
获取疾病类型和预设组织之间的第二对应关系；
基于所述患者的疾病类型和所述第二对应关系，获取所述患者的疾病类型对应的预设组织作为所述患者对应的目标组织。
在一种可能的实现方式中，所述刺激参数为电压的脉宽参数、幅值参数和频率参数中的一个或多个。
在一种可能的实现方式中，所述患者的疾病类型包括癫痫、震颤、帕金森病、抑郁症、强迫症、阿尔茨海默症和药物成瘾症中的一个或多个。
在一种可能的实现方式中，所述程控设备100还包括所述触摸屏101和通信模块102，所述控制器103分别与所述触摸屏101和所述通信模块102电连接；
所述触摸屏101被配置成接收用户的操作，所述通信模块102被配置成实现所述程控设备100与所述刺激器之间的数据交互。
参见图12，本申请还提供了一种植入式神经刺激系统300，其具体实现方式 与上述控制方法的实施例中记载的实施方式、所达到的技术效果一致，部分内容不再赘述。
在一种可能的实现方式中，所述植入式神经刺激系统300包括设置于患者体外的所述程控设备100和植入于所述患者体内的刺激器200；
所述刺激器200被配置成生成电刺激并向所述患者的目标组织施加所述电刺激；
所述程控设备100与所述刺激器200可通信地连接，所述程控设备100包括控制器103：
所述控制器103被配置成：
利用触摸屏101接收滑动操作，响应于所述滑动操作，获取刺激程序的定时信息，所述刺激程序用于指示所述刺激器200的刺激参数的标识和参数值，所述定时信息用于指示开始时刻和结束时刻；
基于所述刺激程序及其的定时信息，生成控制指令并发送至所述刺激器200。
由此，植入式神经刺激系统300可以满足不同患者不同的剌激需求，适用范围广，用户使用体验较佳；并且，用户可以通过滑动操作设置定时信息，相比于通过按键操作逐步调节的方式和直接输入具体数值的方式，大大减少了用户的操作步骤，使得定时信息的设置更为快速便捷，进一步提升用户的使用体验。
需要说明的是，本申请的说明书和权利要求书及上述附图中的术语“第一”、“第二”等是用于区别类似的对象，而不必用于描述特定的顺序或先后次序。应该理解这样使用的数据在适当情况下可以互换，以便这里描述的本申请的实施例能够以除了在这里图示或描述的那些以外的顺序实施。此外，术语“包括”和“具有”以及他们的任何变形，意图在于覆盖不排他的包含，例如，包含了一系列步骤或单元的过程、方法、系统、产品或设备不必限于清楚地列出的那些步骤或单元，而是可包括没有清楚地列出的或对于这些过程、方法、产品或设备固有的其它步骤或单元。
当一个部件被称作“在”另一部件“上”或“之上”、“连接到”或“结合到”另一部件时，该部件可以直接在所述另一部件上、直接连接到或直接结合到所述另一部件，或者可以存在中间部件。然而，当部件被称作“直接在”另一部件“上”、“直接连接到”或“直接结合到”另一部件时，不存在中间部件。为此，术语“连接”可以指物理连接、电气连接等，并且具有或不具有中间部件。本申请从使用目的上，效能上，进步及新颖性等观点进行阐述，本申请以上的说明书及说明书附图，仅 为本申请的较佳实施例而已，并非以此局限本申请，因此，凡一切与本申请构造，装置，特征等近似、雷同的，即凡依本申请专利申请范围所作的等同替换或修饰等，皆应属本申请的专利申请保护的范围之内。

Claims (19)

  1. 一种程控设备，应用于植入式神经刺激系统，所述植入式神经刺激系统包括设置于患者体外的所述程控设备和植入于所述患者体内的刺激器；
    所述程控设备与所述刺激器可通信地连接，所述程控设备包括控制器；
    所述控制器被配置成：
    利用触摸屏接收滑动操作，响应于所述滑动操作，获取刺激程序的定时信息，所述刺激程序用于指示所述刺激器的刺激参数的标识和参数值，所述定时信息用于指示开始时刻和结束时刻；
    基于所述刺激程序及其的定时信息，生成控制指令并发送至所述刺激器，以使所述刺激器根据所述控制指令生成电刺激并向所述患者的目标组织施加所述电刺激。
  2. 根据权利要求1所述的程控设备，其中，所述控制器被配置成采用如下方式获取所述刺激程序的定时信息：
    利用所述触摸屏接收所述滑动操作，响应于所述滑动操作，获取目标程控模式的定时信息，所述目标程控模式用于指示至少一个所述刺激程序；
    基于所述目标程控模式及其定时信息，确定每个所述刺激程序的定时信息。
  3. 根据权利要求2所述的程控设备，其中，所述控制器被进一步配置成采用如下方式获取每个所述刺激程序的定时信息：
    当所述目标程控模式指示单一的刺激程序时，确定所述目标程控模式的定时信息作为所述单一的刺激程序的定时信息；
    当所述目标程控模式指示多个刺激程序时，基于所述目标程控模式的定时信息、每个所述刺激程序的持续时长和所述多个刺激程序的排序，确定每个所述刺激程序的定时信息。
  4. 根据权利要求2所述的程控设备，其中，所述控制器还被配置成：
    当所述目标程控模式的定时信息所对应的第一时间段和预先设置的已有程控模式的定时信息所对应的第二时间段有重合时，确定重合时间段；
    当检测到所述重合时间段是所述第二时间段的部分时，从所述第二时间段中 去除所述重合时间段得到剩余时间段，利用所述剩余时间段更新所述已有程控模式的定时信息。
  5. 根据权利要求4所述的程控设备，其中，所述控制器还被配置成：
    当检测到所述重合时间段是所述第二时间段的全部时，去除所述已有程控模式的定时信息。
  6. 根据权利要求2所述的程控设备，其中，所述控制器还被配置成：
    利用所述触摸屏显示表盘，并在所述表盘的周向显示可滑动的两个滑块，所述两个滑块的位置分别用于指示所述目标程控模式对应的开始时刻和结束时刻；
    所述滑动操作是滑动一个滑块的操作或者滑动两个滑块的操作。
  7. 根据权利要求6所述的程控设备，其中，所述控制器被进一步配置成采用如下方式获取所述目标程控模式的定时信息：
    分别检测滑动每个滑块的操作是否有效，以获取所述滑动操作中的有效操作；
    基于所述有效操作，获取所述目标程控模式的定时信息。
  8. 根据权利要求6所述的程控设备，其中，所述控制器被进一步配置成采用如下方式获取所述目标程控模式的定时信息：
    分别检测滑动每个滑块的操作是否有效，当滑动每个滑块的操作均有效时，获取所述目标程控模式的定时信息。
  9. 根据权利要求7或8所述的程控设备，其中，以被滑动的一个滑块作为目标滑块，检测滑动所述目标滑块的操作是否有效的过程如下：
    基于滑动所述目标滑块的操作，获取所述目标滑块对应的滑动路径，检测所述滑动路径的各轨迹点的位置是否均处于预设滑动区域；
    当所述滑动路径的至少一个轨迹点的位置不处于所述预设滑动区域时，确定滑动所述目标滑块的操作无效；
    当所述滑动路径的各轨迹点的位置均处于所述预设滑动区域时，确定滑动所述目标滑块的操作有效。
  10. 根据权利要求9所述的程控设备，其中，所述控制器被进一步配置成采用如下方式检测滑动所述目标滑块的操作是否有效：
    当所述滑动路径的各轨迹点的位置均处于所述预设滑动区域时，基于所述滑 动路径的起点、终点和路径方向，获取所述滑动路径对应的参考路径，所述参考路径是预设圆周路径的一部分且所述参考路径的路径方向由所述滑动路径的路径方向确定，所述预设圆周路径处于所述预设滑动区域；
    检测所述滑动路径和所述参考路径的相似度是否不小于预设相似度阈值；
    当所述相似度小于所述预设相似度阈值时，确定滑动所述目标滑块的操作无效；
    当所述相似度不小于所述预设相似度阈值时，确定滑动所述目标滑块的操作有效。
  11. 根据权利要求10所述的程控设备，其中，所述控制器被进一步配置成采用如下方式获取所述参考路径：
    在所述预设圆周路径上找到与所述滑动路径的起点距离最近的点，作为所述参考路径的起点；
    在所述预设圆周路径上找到与所述滑动路径的终点距离最近的点，作为所述参考路径的终点；
    基于所述滑动路径的路径方向，从所述预设圆周路径中取所述参考路径的起点到终点之间的路径作为所述参考路径。
  12. 根据权利要求6所述的程控设备，其中，所述两个滑块包括用于指示开始时刻的开始滑块和用于指示结束时刻的结束滑块；
    其中，以所述表盘的中心指向所述开始滑块的向量作为第一向量，以所述表盘的中心指向所述结束滑块的向量作为第二向量，所述第一向量沿所述表盘的顺时针方向到所述第二向量的夹角不超过180度。
  13. 根据权利要求1所述的程控设备，其中，所述控制器还被配置成：
    利用所述触摸屏显示所述刺激器的时钟信息和所述程控设备的时钟信息；
    利用所述触摸屏接收同步操作，响应于所述同步操作，对所述刺激器的时钟信息和所述程控设备的时钟信息进行同步处理。
  14. 根据权利要求2所述的程控设备，其中，所述控制器还被配置成：
    获取疾病类型和预设时长之间的第一对应关系；
    基于所述患者的疾病类型和所述第一对应关系，确定所述患者对应的预设时 长；
    当检测到所述目标程控模式的定时信息所对应的时长大于所述患者对应的预设时长时，提示用户重新操作。
  15. 根据权利要求1所述的程控设备，其中，所述控制器还被配置成：
    获取疾病类型和预设组织之间的第二对应关系；
    基于所述患者的疾病类型和所述第二对应关系，获取所述患者的疾病类型对应的预设组织作为所述患者对应的目标组织。
  16. 根据权利要求1所述的程控设备，其中，所述刺激参数为电压的脉宽参数、幅值参数和频率参数中的一个或多个。
  17. 根据权利要求1所述的程控设备，其中，所述患者的疾病类型包括癫痫、震颤、帕金森病、抑郁症、强迫症、阿尔茨海默症和药物成瘾症中的一个或多个。
  18. 根据权利要求1所述的程控设备，其中，所述程控设备还包括所述触摸屏和通信模块，所述控制器分别与所述触摸屏和所述通信模块电连接；
    所述触摸屏被配置成接收用户的操作，所述通信模块被配置成实现所述程控设备与所述刺激器之间的数据交互。
  19. 一种植入式神经刺激系统，所述植入式神经刺激系统包括设置于患者体外的所述程控设备和植入于所述患者体内的刺激器；
    所述刺激器被配置成生成电刺激并向所述患者的目标组织施加所述电刺激；
    所述程控设备与所述刺激器可通信地连接，所述程控设备包括控制器：
    所述控制器被配置成：
    利用触摸屏接收滑动操作，响应于所述滑动操作，获取刺激程序的定时信息，所述刺激程序用于指示所述刺激器的刺激参数的标识和参数值，所述定时信息用于指示开始时刻和结束时刻；
    基于所述刺激程序及其的定时信息，生成控制指令并发送至所述刺激器。
PCT/CN2022/125083 2022-01-25 2022-10-13 程控设备和植入式神经刺激系统 WO2023142534A1 (zh)

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