WO2023131356A3 - 四氧化三锰颗粒在制备疫苗佐剂中的应用 - Google Patents

四氧化三锰颗粒在制备疫苗佐剂中的应用 Download PDF

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Publication number
WO2023131356A3
WO2023131356A3 PCT/CN2023/079905 CN2023079905W WO2023131356A3 WO 2023131356 A3 WO2023131356 A3 WO 2023131356A3 CN 2023079905 W CN2023079905 W CN 2023079905W WO 2023131356 A3 WO2023131356 A3 WO 2023131356A3
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adjuvant
trimanganese tetraoxide
particle
preparation
tetraoxide particles
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PCT/CN2023/079905
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English (en)
French (fr)
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WO2023131356A2 (zh
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王亚玲
陈春英
赵宇亮
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广东粤港澳大湾区国家纳米科技创新研究院
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Publication of WO2023131356A2 publication Critical patent/WO2023131356A2/zh
Publication of WO2023131356A3 publication Critical patent/WO2023131356A3/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

本发明公开了四氧化三锰颗粒在制备疫苗佐剂中的应用，所述佐剂为颗粒佐剂，所述颗粒佐剂为外部包裹有或没有赋形剂的四氧化三锰颗粒，所述颗粒佐剂粒径为5～3000nm。本发明所提供的四氧化三锰颗粒佐剂能够有效结合单链核苷酸佐剂并能有效载带免疫抗原，能够在较少的抗原剂量和较低的注射使用量时，获得更加优异的免疫治疗效果；高效的激活免疫细胞，实现平衡的体液和细胞免疫。
PCT/CN2023/079905 2022-01-07 2023-03-06 四氧化三锰颗粒在制备疫苗佐剂中的应用 WO2023131356A2 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202210018495.5 2022-01-07
CN202210018495.5A CN114432437A (zh) 2022-01-07 2022-01-07 四氧化三锰颗粒在制备疫苗佐剂中的应用

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WO2023131356A2 WO2023131356A2 (zh) 2023-07-13
WO2023131356A3 true WO2023131356A3 (zh) 2023-08-24

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Publication number Priority date Publication date Assignee Title
CN114432437A (zh) * 2022-01-07 2022-05-06 广东粤港澳大湾区国家纳米科技创新研究院 四氧化三锰颗粒在制备疫苗佐剂中的应用
CN114848810B (zh) * 2022-05-11 2023-10-10 江南大学 一种手性纳米疫苗及其制备方法与应用

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CN114432437A (zh) 2022-05-06

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