WO2023128883A1 - Composition containing microalgae extract for use in the treatment of seborrheic dermatitis - Google Patents
Composition containing microalgae extract for use in the treatment of seborrheic dermatitis Download PDFInfo
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- WO2023128883A1 WO2023128883A1 PCT/TR2021/051525 TR2021051525W WO2023128883A1 WO 2023128883 A1 WO2023128883 A1 WO 2023128883A1 TR 2021051525 W TR2021051525 W TR 2021051525W WO 2023128883 A1 WO2023128883 A1 WO 2023128883A1
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- WIPO (PCT)
- Prior art keywords
- weight
- oil
- edta
- extract
- ethylenediamine tetraacetic
- Prior art date
Links
- 239000000284 extract Substances 0.000 title claims abstract description 32
- 239000000203 mixture Substances 0.000 title claims abstract description 29
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 title claims abstract description 16
- 208000008742 seborrheic dermatitis Diseases 0.000 title claims abstract description 16
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- 230000000845 anti-microbial effect Effects 0.000 claims abstract description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 39
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 36
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 30
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 24
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 24
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 229910001868 water Inorganic materials 0.000 claims description 16
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 14
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- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 claims description 9
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- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 8
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- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 7
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 7
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- 150000004676 glycans Chemical class 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
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- 239000005017 polysaccharide Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 241001467606 Bacillariophyceae Species 0.000 description 1
- 241000206761 Bacillariophyta Species 0.000 description 1
- 239000002028 Biomass Substances 0.000 description 1
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- 241001312951 Corallina pilulifera Species 0.000 description 1
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- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
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- 241000911022 Symphyocladia latiuscula Species 0.000 description 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 description 1
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- 239000000419 plant extract Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 208000004223 riboflavin deficiency Diseases 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- VIDTVPHHDGRGAF-UHFFFAOYSA-N selenium sulfide Chemical compound [Se]=S VIDTVPHHDGRGAF-UHFFFAOYSA-N 0.000 description 1
- 229960005265 selenium sulfide Drugs 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 229960002668 sodium chloride Drugs 0.000 description 1
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- 150000003431 steroids Chemical class 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229960001967 tacrolimus Drugs 0.000 description 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 description 1
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- 239000003643 water by type Substances 0.000 description 1
- 229940043810 zinc pyrithione Drugs 0.000 description 1
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/382—Vegetable products, e.g. soya meal, wood flour, sawdust
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/38—Products in which the composition is not well defined
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
Definitions
- the invention relates to a composition containing microalgae extract with antimicrobial and scalp moisturizing properties for use in the treatment of seborrheic dermatitis.
- Seborrheic dermatitis is a chronic and recurrent inflammatory skin disease that appears as erythematous and dandruff form. The exact cause is unknown and it is a multifactorial disorder caused by many factors. Depression, stress, exhaustion, seasonal and weather changes, dietary patterns, various allergies, riboflavin and biotin deficiencies and weak immunity are examples of these factors. Also, Maias sezia furfur is the type of microorganism that causes this disorder. Treatment of the disease is usually directed towards controlling the symptoms. Antifungals, retinoids, corticosteroids and phototherapy are currently used in the treatment. Another type of treatment is topical methods.
- Combination treatments containing salicylic acid, coal tar, juniper tar, selenium sulfide, zinc pyrithione, benzylamines, tacrolimus, dandruff shampoos, antifungal agents and topical steroids, lithium compounds, corticosteroids, tea tree oil, aloe vera extract and PEG are examples of topical methods (Aksoy and Aksu- Arica 2016).
- Seborrheic dermatitis disease causes a serious negative impact on people's quality of life, and even after successful treatment, the disease tends to recur. Its formation appears to be related to the proliferation of commensal Malassezia species (Garry 2013).
- Microalgae are monocellular organisms that live in seas and fresh waters and are capable of photosynthesis. Microalgae produce about half of the oxygen in the atmosphere. Common types of microalgae are diatoms (Bacillariophyceae), green algae (Chlorophyceae) and golden algae (Chry sophy ceae).
- Microalgae produce organic substances such as carbohydrates, proteins and fatty acids by using sunlight and inorganic substances (for example, carbon dioxide, water, nitrogen, phosphorus). Recently, the interest in sustainable world and green technology has been increasing. With this approach, bioactive substances produced by microalgae are used for different purposes in sectors such as cosmetics, food and medicine. In addition to the high nutritional value of microalgae, bioactive substances such as chlorophyll and carotenoids produced by microalgae are used as natural colorants in the food industry and in the cosmetics industry because of their antioxidant properties.
- the cosmetic industry is committed to developing and finding natural, sustainable, economic and organic ingredients to provide new and innovative products that meet the needs and demands of customers. Therefore, algae are used as a reliable natural and organic active component in various cosmetic products to increase the value of these products.
- the bioactive substances used for this purpose are components such as polysaccharides, proteins and pigments produced by microalgae. These components act as antioxidant, anti-inflammatory, anti-aging, anti-wrinkle, moisturizer, photo-protective, thinning, anti-melanin and collagen- boosting agent and improve the health, condition and appearance of the skin.
- the patent document numbered CN111388375A relates to a skin care product containing plant extract, which tightens the skin and provides resistance against aging.
- microalgal extract contains microalgal extract.
- cosmetic product formulation containing microalgal extract against this disease.
- national patents it has been observed that there is no shampoo and/or cosmetic product containing microalgae specific to seborrheic dermatitis.
- microalgae The most important advantages of microalgae are that they are easy to produce (accessible to obtain raw materials), their nutritional needs are low, they grow rapidly, and they do not cause any harm to the environment and living things.
- anti- seborrheic dermatitis shampoos dry the hair, create odor problems, they are expensive, and contain sulfate and paraben, and the primary purpose of this invention is to produce shampoos and soaps with relatively cleaner content compared to these shampoos.
- microalgae species Chlorella, Dunaliella, Hematococcus, Nannochloropsis, Tetraselmis, Spirulina, Isochrysis, Scenedesmus, Chaetoceros, Skeletonema, Schizochytrium, Botryococcus, Prymnesium, Porphyridium, Pavlova, Thalassiosira, Chlamydomonas, Nitzschia species
- the developed product contains extracts of different types of microalgae (Chlorella, Dunaliella, Hematococcus, Nannochloropsis, Tetraselmis, Spirulina, Isochrysis, Scenedesmus, Chaetoceros, Skeletonema, Schizochytrium, Botryococcus, Prymnesium, Porphyridium, Pavlova, Thalassiosira, Chlamydomonas, Nitzschia species) with antimicrobial properties during the growth phase.
- microalgae Chlorella, Dunaliella, Hematococcus, Nannochloropsis, Tetraselmis, Spirulina, Isochrysis, Scenedesmus, Chaetoceros, Skeletonema, Schizochytrium, Botryococcus, Prymnesium, Porphyridium, Pavlova, Thalassiosira, Chlamydomonas, Nitzschia species
- the shampoo composition containing microalgae extract which is antimicrobial and moisturizing for the scalp and hairless skin, to be used in the treatment of seborrheic dermatitis, comprises lauryl glycoside, water, glycerin, benzophenone, ethylenediamine tetraacetic acid (EDTA), coconut oil, glycol distearate, tea tree oil, jojoba oil, vitamin E, betaine, hydrogenated castor oil polyethylene glycol (PEG 40), cocamide diethanol amine, citric acid (the amount will vary according to pH), sodium chloride and microalgal oil extract.
- EDTA ethylenediamine tetraacetic acid
- coconut oil glycol distearate
- tea tree oil jojoba oil
- vitamin E betaine
- PEG 40 hydrogenated castor oil polyethylene glycol
- cocamide diethanol amine citric acid (the amount will vary according to pH), sodium chloride and microalgal oil extract.
- This composition comprises 8-12% by weight of lauryl glycoside, 2-5% by weight of betaine, 2-3% by weight of hydrogenated castor oil polyethylene glycol (PEG 40), 0.1-1% by weight of cocamide diethanolamine (Cocamide DEA), 0.1-1% by weight of coconut oil, 0.1- 1% by weight of sodium chloride (NaCl), 1-2% by weight of glycol distearate, 0.1-0.5% by weight of jojoba oil, 01-0.5% by weight of vitamin E, 0.1-0.3% by weight of benzophenone, 1-3% by weight of glycerine, 0.05-0.15% by weight of ethylenediamine tetraacetic acid (EDTA), 0.05-0.2% by weight of tea tree oil and 0.1-1.5% by weight of a microalgal oil extract.
- PEG 40 hydrogenated castor oil polyethylene glycol
- Cocamide DEA cocamide diethanolamine
- NaCl sodium chloride
- jojoba oil 01-0.5% by weight of vitamin E
- Benzophenone acts as a color protectant and helps to increase the resistance of the cosmetic product against airborne molecules; foaming agent as lauryl glycoside surfactant; cocamide diethanolamine as hair conditioner; coconut oil as emollient; glycol distearate as a psoriasis agent; jojoba oil and vitamin E as preservatives; glycerin as enhancer of moisturizing effect; ethylenediamine tetraacetic acid (EDTA) as water softener and chelating agent; hydrogenated castor oil polyethylene glycol (PEG40) as emulsifier odorant; tea tree oil as an odorizer and antimicrobial agent; citric acid as pH adjuster and removal of dead skin cells; betaine as a foaming agent and sodium chloride as a stabilizer and soothing agent on the skin.
- Algal oil extract exhibits antifungal, antibacterial, moisturizing, anti-aging and soothing effects.
- EDTA Ethylenediamine tetraacetic acid
- coconut oil tea tree oil
- jojoba oil microalgal oil extract
- betaine vitamin E
- cocamide di ethanol amine glycol distearate
- benzophenone sodium chloride (NaCl) solution dissolved in water
- Solid materials such as ethylenediamine tetraacetic acid (EDTA), sodium chloride, citric acid and benzophenone should be added by dissolving in pure water.
- hydrogenated castor oil polyethylene glycol (PEG 40) is added to the mixture. While preparing the shampoo, it should be stirred at 150 rpm continuously.
- the soap composition containing microalgae extract which is antimicrobial and moisturizing for the scalp and hairless skin, to be used in the treatment of seborrheic dermatitis, comprises sodium hydroxide (NaOH), tea tree oil, lavender oil, glycerin, ethylenediamine tetraacetic acid (EDTA), fragrance, water and microalgal extract.
- NaOH sodium hydroxide
- tea tree oil lavender oil
- glycerin ethylenediamine tetraacetic acid
- fragrance water and microalgal extract.
- This composition comprises 20-70% by weight of microalgal oil extract, 10-30% by weight of sodium hydroxide (NaOH), 0.05-0.2% by weight of tea tree oil, 0.05-0.2% by weight of lavender oil, 1-20% by weight of glycerin, 1-5% by weight of ethylenediamine tetraacetic acid (EDTA), and 0.5-2.5% by weight of fragrance.
- NaOH sodium hydroxide
- EDTA ethylenediamine tetraacetic acid
- microalgal oil which has been heated to 35°C, is poured into the beaker. Then, lavender oil and tea tree oil are added to the microalgal oil. Then, ethylenediamine tetraacetic acid (EDTA) dissolved in water is added as a deodorizer and glycerine is added to increase the moisturizing.
- EDTA ethylenediamine tetraacetic acid
- sodium hydroxide (NaOH) solution is added to the mixture and the mixture is mixed until it reaches a homogeneous appearance. Then, sodium chloride (NaCl) solution is slowly added to the soap, which is cooled to room temperature (25°C), and excess NaOH solution is removed. Then, the soap is washed by pouring cold water (+4°C).
- Microalgae extract in the composition of the invention comprises the extract of one or more species selected from Chlorella, Dunaliella, Hematococcus, Nannochloropsis, Tetraselmis, Spirulina, Isochrysis, Scenedesmus, Chaetoceros, Skeletonema, Schizochytrium, Botryococcus, Prymnesium, Porphyridium, Pavlova, Thalassiosira, Chlamydomonas, Nitzschia species.
- the invention consists of a shampoo and soap formulation containing the microalgae extract mentioned above.
- Microalgae extract offers antimicrobial and moisturizing effects to the cosmetic product.
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Abstract
The invention relates to a composition containing microalgae extract with antimicrobial and scalp moisturizing properties for use in the treatment of seborrheic dermatitis.
Description
COMPOSITION CONTAINING MICROALGAE EXTRACT FOR USE IN THE TREATMENT OF SEBORRHEIC DERMATITIS
Technical Field of the Invention
The invention relates to a composition containing microalgae extract with antimicrobial and scalp moisturizing properties for use in the treatment of seborrheic dermatitis.
State of the Art of the Invention (Prior Art)
It is seen that people who have problems with hair health experience loss of self-confidence, and if the symptoms of these hair disorders are not treated, the quality of life of the people is negatively affected. Although the literature on the prevalence and spectrum of scalp disease is limited, in a study conducted by Ogrum et al. (2019) by including 1857 female patients over the age of 18 who applied to the dermatological and venereal diseases outpatient clinic between February 2015 and February 2018, it is determined that the ratio of hair and scalp disease in the reasons for applying to the dermatology outpatient clinic, especially in women, is 11.09%. Seborrheic dermatitis problem is observed with the highest rate of 43.5% among the people who apply for hair and scalp disease.
Seborrheic dermatitis is a chronic and recurrent inflammatory skin disease that appears as erythematous and dandruff form. The exact cause is unknown and it is a multifactorial disorder caused by many factors. Depression, stress, exhaustion, seasonal and weather changes, dietary patterns, various allergies, riboflavin and biotin deficiencies and weak immunity are examples of these factors. Also, Maias sezia furfur is the type of microorganism that causes this disorder. Treatment of the disease is usually directed towards controlling the symptoms. Antifungals, retinoids, corticosteroids and phototherapy are currently used in the treatment. Another type of treatment is topical methods. Combination treatments containing salicylic acid, coal tar, juniper tar, selenium sulfide, zinc pyrithione, benzylamines, tacrolimus, dandruff shampoos, antifungal agents and topical steroids, lithium compounds,
corticosteroids, tea tree oil, aloe vera extract and PEG are examples of topical methods (Aksoy and Aksu- Arica 2016).
Seborrheic dermatitis disease causes a serious negative impact on people's quality of life, and even after successful treatment, the disease tends to recur. Its formation appears to be related to the proliferation of commensal Malassezia species (Garry 2013).
In a study conducted by Choi et al. (2009), 57 different seaweed species were screened for antifungal activity against Malassezia species. The antifungal effects against M. furfur and M. restta were examined and screened 17 (29.8%) of the 57 seaweed species exhibited inhibitory activity. Species showing strong antifungal activity in the study are Corallina pilulifera, Enteromorpha linza, Laminaria japonica, Symphyocladia latiuscula and Ulva species. In this study, it was concluded that seaweed extracts are valuable for the development of therapeutic agents in the treatment of dandruff and seborrheic dermatitis. Regarding toxicity, it has been observed that the experiments did not show any toxic effects in mice, since seaweed extracts contain fatty acid content, and studies on the subject are still in progress (Choi et al., 2009).
Microalgae are monocellular organisms that live in seas and fresh waters and are capable of photosynthesis. Microalgae produce about half of the oxygen in the atmosphere. Common types of microalgae are diatoms (Bacillariophyceae), green algae (Chlorophyceae) and golden algae (Chry sophy ceae).
Microalgae produce organic substances such as carbohydrates, proteins and fatty acids by using sunlight and inorganic substances (for example, carbon dioxide, water, nitrogen, phosphorus). Recently, the interest in sustainable world and green technology has been increasing. With this approach, bioactive substances produced by microalgae are used for different purposes in sectors such as cosmetics, food and medicine. In addition to the high nutritional value of microalgae, bioactive substances such as chlorophyll and carotenoids produced by microalgae are used as natural colorants in the food industry and in the cosmetics industry because of their antioxidant properties. In the studies, it has been determined that fatty acids, proteins, polysaccharides, lipids, vitamins, enzymes and other biologically active compounds in the structure of some microalgae species are effective against bacteria, viruses,
fungi and cancer. For example, blue-green algae (Cyanobacteria) has been found to be effective against viruses (Morais M. et al. 2014).
The cosmetic industry is committed to developing and finding natural, sustainable, economic and organic ingredients to provide new and innovative products that meet the needs and demands of customers. Therefore, algae are used as a reliable natural and organic active component in various cosmetic products to increase the value of these products. The bioactive substances used for this purpose are components such as polysaccharides, proteins and pigments produced by microalgae. These components act as antioxidant, anti-inflammatory, anti-aging, anti-wrinkle, moisturizer, photo-protective, thinning, anti-melanin and collagen- boosting agent and improve the health, condition and appearance of the skin.
With this invention, it is aimed to produce cosmetic products with bioactive component microalgae extract, which have both natural content and antibacterial, antifungal, anti-aging and moisturizing effects. Shampoo containing microalgae, which is the invention, will be an alternative to antifungal shampoos against seborrheic dermatitis.
The patent document numbered US9205040B2 found in the literature relates to cosmetic compositions containing microalgae biomass and microalgae oil. The content of the formulation and the products and proportions used therein differ from the invention.
The patent document numbered CN111388375A relates to a skin care product containing plant extract, which tightens the skin and provides resistance against aging.
In the documents available as a result of the researches, there is no cleaning composition containing microalgae extract, which is antimicrobial and moisturizing for the scalp.
Brief Description and Objects of the Invention
The main difference of the invention from the solutions in the state of the art is that it contains microalgal extract. According to the researches, it has been observed that there is no product containing microalgal extract for use in the treatment of seborrheic dermatitis. When academic publications are examined, there is no cosmetic product formulation containing
microalgal extract against this disease. However, when national patents are scanned, it has been observed that there is no shampoo and/or cosmetic product containing microalgae specific to seborrheic dermatitis.
The most important advantages of microalgae are that they are easy to produce (accessible to obtain raw materials), their nutritional needs are low, they grow rapidly, and they do not cause any harm to the environment and living things. Currently, there are disadvantages that anti- seborrheic dermatitis shampoos dry the hair, create odor problems, they are expensive, and contain sulfate and paraben, and the primary purpose of this invention is to produce shampoos and soaps with relatively cleaner content compared to these shampoos.
Although there is a microalgae contribution in the content of cosmetic products in the sector, different types of microalgae species (Chlorella, Dunaliella, Hematococcus, Nannochloropsis, Tetraselmis, Spirulina, Isochrysis, Scenedesmus, Chaetoceros, Skeletonema, Schizochytrium, Botryococcus, Prymnesium, Porphyridium, Pavlova, Thalassiosira, Chlamydomonas, Nitzschia species) with improved properties are used in the developed product.
In addition to the classical shampoo and soap formulation, the developed product contains extracts of different types of microalgae (Chlorella, Dunaliella, Hematococcus, Nannochloropsis, Tetraselmis, Spirulina, Isochrysis, Scenedesmus, Chaetoceros, Skeletonema, Schizochytrium, Botryococcus, Prymnesium, Porphyridium, Pavlova, Thalassiosira, Chlamydomonas, Nitzschia species) with antimicrobial properties during the growth phase.
Definitions of Figures Illustrating the Invention
Figure 1: Measurement of inhibition against E. coli and S. aeurus bacteria by disk diffusion method of oil extract
Detailed Description of the Invention
As shown in Table 1, the shampoo composition containing microalgae extract, which is antimicrobial and moisturizing for the scalp and hairless skin, to be used in the treatment of seborrheic dermatitis, comprises lauryl glycoside, water, glycerin, benzophenone, ethylenediamine tetraacetic acid (EDTA), coconut oil, glycol distearate, tea tree oil, jojoba oil, vitamin E, betaine, hydrogenated castor oil polyethylene glycol (PEG 40), cocamide diethanol amine, citric acid (the amount will vary according to pH), sodium chloride and microalgal oil extract. This composition comprises 8-12% by weight of lauryl glycoside, 2-5% by weight of betaine, 2-3% by weight of hydrogenated castor oil polyethylene glycol (PEG 40), 0.1-1% by weight of cocamide diethanolamine (Cocamide DEA), 0.1-1% by weight of coconut oil, 0.1- 1% by weight of sodium chloride (NaCl), 1-2% by weight of glycol distearate, 0.1-0.5% by weight of jojoba oil, 01-0.5% by weight of vitamin E, 0.1-0.3% by weight of benzophenone, 1-3% by weight of glycerine, 0.05-0.15% by weight of ethylenediamine tetraacetic acid (EDTA), 0.05-0.2% by weight of tea tree oil and 0.1-1.5% by weight of a microalgal oil extract.
Benzophenone acts as a color protectant and helps to increase the resistance of the cosmetic product against airborne molecules; foaming agent as lauryl glycoside surfactant; cocamide diethanolamine as hair conditioner; coconut oil as emollient; glycol distearate as a psoriasis agent; jojoba oil and vitamin E as preservatives; glycerin as enhancer of moisturizing effect; ethylenediamine tetraacetic acid (EDTA) as water softener and chelating agent; hydrogenated castor oil polyethylene glycol (PEG40) as emulsifier odorant; tea tree oil as an odorizer and antimicrobial agent; citric acid as pH adjuster and removal of dead skin cells; betaine as a foaming agent and sodium chloride as a stabilizer and soothing agent on the skin. Algal oil extract exhibits antifungal, antibacterial, moisturizing, anti-aging and soothing effects.
In the production of shampoo, water, Ethylenediamine tetraacetic acid (EDTA), coconut oil, tea tree oil, jojoba oil, microalgal oil extract, betaine, vitamin E, cocamide di ethanol amine, glycol distearate, benzophenone, sodium chloride (NaCl) solution dissolved in water are added to the mixture sequentially. Solid materials such as ethylenediamine tetraacetic acid (EDTA), sodium chloride, citric acid and benzophenone should be added by dissolving in pure water. Finally, hydrogenated castor oil polyethylene glycol (PEG 40) is added to the
mixture. While preparing the shampoo, it should be stirred at 150 rpm continuously. Lower speeds are not suitable for obtaining a homogeneous mixture. Higher speeds cause the mixture to stick to the walls of the container. It is prepared by calculating the raw materials and pure water by weight. The pH is buffered (to stabilize the pH), first lowered to 4 and then increased to 7.5. The pH is adjusted to 5.5 by using citric acid before the final step. Finally, the shampoo is cooled and bottled and made ready for analysis and stability tests.
As shown in Table 2, the soap composition containing microalgae extract, which is antimicrobial and moisturizing for the scalp and hairless skin, to be used in the treatment of seborrheic dermatitis, comprises sodium hydroxide (NaOH), tea tree oil, lavender oil, glycerin, ethylenediamine tetraacetic acid (EDTA), fragrance, water and microalgal extract. This composition comprises 20-70% by weight of microalgal oil extract, 10-30% by weight of sodium hydroxide (NaOH), 0.05-0.2% by weight of tea tree oil, 0.05-0.2% by weight of lavender oil, 1-20% by weight of glycerin, 1-5% by weight of ethylenediamine tetraacetic acid (EDTA), and 0.5-2.5% by weight of fragrance.
For producing soap, microalgal oil, which has been heated to 35°C, is poured into the beaker. Then, lavender oil and tea tree oil are added to the microalgal oil. Then, ethylenediamine tetraacetic acid (EDTA) dissolved in water is added as a deodorizer and glycerine is added to increase the moisturizing. After these processes, sodium hydroxide (NaOH) solution is added to the mixture and the mixture is mixed until it reaches a homogeneous appearance. Then, sodium chloride (NaCl) solution is slowly added to the soap, which is cooled to room temperature (25°C), and excess NaOH solution is removed. Then, the soap is washed by pouring cold water (+4°C).
Table 1: Inventive shampoo content and percentage components
Table 2: Inventive soap content and percentage components
Microalgae extract in the composition of the invention comprises the extract of one or more species selected from Chlorella, Dunaliella, Hematococcus, Nannochloropsis, Tetraselmis, Spirulina, Isochrysis, Scenedesmus, Chaetoceros, Skeletonema, Schizochytrium, Botryococcus, Prymnesium, Porphyridium, Pavlova, Thalassiosira, Chlamydomonas, Nitzschia species.
Unlike existing algae-containing cosmetic products, there is no anti-seborrheic dermatitis shampoo/soap cosmetic product formulation containing microalgae.
The invention consists of a shampoo and soap formulation containing the microalgae extract mentioned above. Microalgae extract offers antimicrobial and moisturizing effects to the cosmetic product.
It is seen that the algal extract Chlorella species was used) used in Figure 1 has antibacterial effects on E. coli and S. aeurus. As the amount of algal extract increases, its effect also increases.
Claims
CLAIMS A composition comprising microalgae extract, which has antimicrobial properties and moisturizing properties for the scalp and hairless skin, to be used in the treatment of seborrheic dermatitis, characterized in that it comprises microalgae oil extract prepared with one or more microalgae selected from the microalgae species of Chlor ella, Dunaliella, Hematococcus, Nannochloropsis, Tetraselmis, Spirulina, Isochrysis, Scenedesmus, Chaetoceros, Skeletonema, Schizochytrium, Botryococcus, Prymnesium, Porphyridium, Pavlova, Thalassiosira, Chlamydomonas, Nitzschia . A composition according to claim 1, characterized in that it comprises lauryl glycoside, water, betaine, cocamide diethanolamine, tea tree oil, jojoba oil, coconut oil, vitamin E, glycerine, benzophenone, Ethylenediamine tetraacetic acid (EDTA), hydrogenated castor oil polyethylene glycol (PEG 40), glycol distearate, citric acid, sodium chloride (NaCl). A composition according to claim 2, characterized in that it comprises 8-12% by weight of lauryl glycoside, 2-5% by weight of betaine, 2-3% by weight of hydrogenated castor oil polyethylene glycol (PEG 40), 0.1-1% by weight of cocamide diethanolamine (Cocamide DEA), 0.1-1% by weight of coconut oil, 0.1-1% by weight of sodium chloride (NaCl), 1-2% by weight of glycol distearate, 0.1-0.5% by weight of jojoba oil, 01-0.5% by weight of vitamin E, 0.1-0.3% by weight of benzophenone, 1-3% by weight of glycerine, 0.05-0.15% by weight of ethylenediamine tetraacetic acid (EDTA), 0.05-0.2% by weight of tea tree oil and 0.1-1.5% by weight of a microalgal oil extract. A shampoo comprising the composition according to claim 2 or 3. A composition according to claim 1, characterized in that it comprises sodium hydroxide (NaOH), tea tree oil, lavender oil, glycerin, ethylenediamine tetraacetic acid (EDTA), fragrance and water.
9
6. A composition according to claim 5, characterized in that it comprises 20-70% by weight of microalgal oil extract, 10-30% by weight of sodium hydroxide (NaOH), 0.05-0.2% by weight of tea tree oil, 0.05-0.2% by weight of lavender oil, 1-20% by weight of glycerin, 1-5% by weight of ethylenediamine tetraacetic acid (EDTA), and 0.5-2.5% by weight of fragrance.
7. The soap comprising the composition according to claim 5 or 6.
8. A method for preparing the shampoo according to claim 4, characterized in that it includes the steps of
• Adding 8-12% by weight of lauryl glycoside first, then to round up to 100 by weight, adding pure water, 2-5% of betaine, 0.1-1% of cocamide diethanol amine, 0.1-1.5% of microalgal oil extract, 0.05-0.2% of tea tree oil, 0.1-05% of jojoba oil, 0.1-1% of coconut oil, 0.1-0.5% of vitamin E, 1-3% of glycerin, 0.1-0.3% of benzophenone, 0.05-0.15% of Ethylenediamine tetraacetic acid (EDTA), 2-3% of hydrogenated castor oil polyethylene glycol (PEG 40), 1-2% of glycol distearate, (the amount will change depending on the pH) citric acid, 1-2% of sodium chloride (NaCl) and other substances,
• Dissolving solid materials such as ethylenediamine tetraacetic acid (EDTA) and benzophenone, sodium chloride, citric acid in pure water and adding.
• Finally, adding hydrogenated castor oil polyethylene glycol PEG 40,
• Continuous mixing of all ingredients at 150 rpm while preparing the shampoo
• buffering the pH (to stabilize the pH), firstly lowering to 4, then increasing to 7.5,
• Adjusting the pH before the final step
• Adjusting the pH to 5.5 using citric acid
• Finally, cooling and bottling the shampoo and making it ready for analysis and stability tests.
9. A method of soap according to claim 7, characterized in that it includes the steps of;
Heating microalgal oil to 35°C,
• Then adding lavender oil and tea tree oil,
• Adding ethylenediamine tetraacetic acid (EDTA) as a deodoriser, Adding glycerine to increase its moisturizing properties,
• Then, adding NaOH solution and stirring the mixture until it becomes smooth, • Then, slowly adding sodium chloride (NaCl) solution to the soap, which is cooled to room temperature (25°C), and removing excess NaOH solution,
• Washing the soap with cold water by pouring cold water at +4°C into soap.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016026723A2 (en) * | 2014-08-19 | 2016-02-25 | Cutech Srl | Extracts of nannochloropsis sp. and their applications |
| EP3177305A2 (en) * | 2014-08-05 | 2017-06-14 | Cutech S.R.L. | Extracts of microalgae and plants for regulating sebum production |
| CN110812268A (en) * | 2020-01-02 | 2020-02-21 | 周博 | Liquid shampoo for treating seborrheic dermatitis |
-
2021
- 2021-12-27 WO PCT/TR2021/051525 patent/WO2023128883A1/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3177305A2 (en) * | 2014-08-05 | 2017-06-14 | Cutech S.R.L. | Extracts of microalgae and plants for regulating sebum production |
| WO2016026723A2 (en) * | 2014-08-19 | 2016-02-25 | Cutech Srl | Extracts of nannochloropsis sp. and their applications |
| CN110812268A (en) * | 2020-01-02 | 2020-02-21 | 周博 | Liquid shampoo for treating seborrheic dermatitis |
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