WO2023125471A1 - Nébuliseur et élément de guidage d'écoulement de gaz associé - Google Patents

Nébuliseur et élément de guidage d'écoulement de gaz associé Download PDF

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Publication number
WO2023125471A1
WO2023125471A1 PCT/CN2022/142149 CN2022142149W WO2023125471A1 WO 2023125471 A1 WO2023125471 A1 WO 2023125471A1 CN 2022142149 W CN2022142149 W CN 2022142149W WO 2023125471 A1 WO2023125471 A1 WO 2023125471A1
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WIPO (PCT)
Prior art keywords
pharmaceutically acceptable
outlet
acceptable salt
inlet
spray
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PCT/CN2022/142149
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English (en)
Chinese (zh)
Inventor
贺素敏
林旭其
曹立
游劲松
黄芳芳
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广东东阳光药业有限公司
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Publication of WO2023125471A1 publication Critical patent/WO2023125471A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes

Definitions

  • the invention belongs to the technical field of medical devices, and in particular relates to an airflow guide, an atomizer, a spray assembly and uses thereof.
  • Nebulization inhalation for chronic obstructive pulmonary disease and asthma is the preferred method of administration recommended by relevant treatment guidelines.
  • the nebulizer nebulizes the liquid medicine into an inhalable liquid with the aerodynamic particle size of most of the droplets being 1-5um. Drops, after oral inhalation, the drug can directly reach the lung lesion, so that the drug can fully produce local effects. The effect provided by this method is more efficient and direct than the general oral drug.
  • the spray port is located at the end of the airflow auxiliary guide, and the lower auxiliary drainage opening is located on the side wall of the gas auxiliary guidance, and then the external air passes through the lower auxiliary drainage opening.
  • the spray is introduced into the auxiliary guiding channel of the auxiliary air flow guide and pushes up the spray that enters the auxiliary guiding channel of the auxiliary air flow guide through the spray opening.
  • the lower auxiliary drainage opening is located in the middle of the auxiliary guiding channel, not all the external air introduced into the auxiliary guiding channel due to negative pressure flows in the predetermined direction, and a small part of the external air will flow in the auxiliary guiding channel.
  • the spray diffuses in the channel and collides with the spray, so that the spray accumulates in a large amount on the inner wall of the auxiliary guiding channel and forms residues, which makes it impossible to accurately control the atomized dosage of the nebulizer.
  • the purpose of the present invention is to provide an airflow guide, an atomizer, a spray assembly and its application, so as to solve the problem that the airflow guide of the nebulizer in the prior art cannot accurately control the nebulizer’s atomized dosage.
  • the problem is to provide an airflow guide, an atomizer, a spray assembly and its application, so as to solve the problem that the airflow guide of the nebulizer in the prior art cannot accurately control the nebulizer’s atomized dosage. The problem.
  • the atomizer airflow guide provided by the present invention includes: a first pipe body, on which a first inlet, a first outlet, and a first guide connecting the first inlet and the first outlet are arranged. Guide passage; second pipe body, the second pipe body is provided with a second inlet, a second outlet and a second guide passage communicating with the second inlet and second outlet; the end of the second pipe body The part is located in the first pipe body, and the second outlet is located between the first inlet and the first outlet.
  • the area ratio of the first inlet and the first outlet is 1:(1-10).
  • the area ratio of the first inlet and the first outlet is 1:(2-5). In some embodiments, the area ratio of the first inlet and the first outlet is 1:(1.8-2.3). In some embodiments, the area ratio of the first inlet and the first outlet is 1:(1.5-3). In some embodiments, the area ratio of the first inlet and the first outlet is 1:1.8. In some embodiments, the area ratio of the first inlet and the first outlet is 1:2.3. In some embodiments, the area ratio of the first inlet and the first outlet is 1:1, or 1:2, or 1:3, or 1:4, or 1:5, or 1:6, Or 1:7, or 1:8, or 1:9, or 1:10, or 1:11, or 1:12.
  • the second outlet end surface is located between the second interface of the first inlet and the first outlet end surface.
  • the first inlet is one or more, and is provided on the side wall of the first pipe body, or is provided at the end of the first guide passage and located in the opposite direction of the first outlet, the first inlet is a standard round, square or other special shape, the angle of the inlet is perpendicular to the side wall of the first pipe body, or other various inclined angles; the first outlet It is arranged at the end of the first pipe body.
  • the first inlet is multiple and surrounds the outer wall of the first tube body, or is located at the end of the first guide channel. The opposite reverse of the first exit.
  • the second inlet is provided with a first installation part, and the installation part is suitable for installing a medicine bottle; the second outlet is provided with a second installation part. part, the second installation part is suitable for installing the atomization module.
  • the second outlet is provided with a second mounting portion which is a stepped hole, and the stepped hole is suitable for placing an atomizing component.
  • the mounting part of the second inlet is provided with a screw hole to facilitate the installation of a medicine bottle
  • the second outlet is provided with a stepped hole to facilitate the installation of an atomizing sheet.
  • the area of the second inlet is 50mm 2 -300mm 2
  • the area of the second outlet is 100mm 2 -300mm 2 .
  • the second pipe body is an elbow, and is suitable for making the angle between the central axis of the second inlet and the central axis of the second outlet 90°-150°.
  • the present invention also discloses an atomizer, which includes the airflow guide described in any one of the above.
  • the above-mentioned atomizer further preferably, further includes: a housing, the housing is detachably connected to the outside of the airflow guide; an atomization module, including an atomization sheet, and the atomization sheet is installed on the The second outlet is suitable for contacting and connecting with the medicine bottle to vibrate and atomize the medicine liquid.
  • the atomizer as described above further preferably, further includes a first gasket, a second gasket and a nozzle pressing plate, and the first gasket, the second gasket and the nozzle pressing plate are sequentially installed at the second outlet from the inside to the outside ; The atomizing sheet is clamped between the first gasket and the second gasket.
  • the present invention also provides a spray assembly, including spray and the aforementioned atomizer, the active ingredients in the spray are ⁇ 2 receptor agonist, glucocorticoid, muscarinic receptor antagonist and phosphodiesterase At least one of the 4 inhibitors.
  • the spray kit comprises a ⁇ 2-receptor agonist single spray.
  • the spray kit comprises a glucocorticoid single spray.
  • the spray kit comprises a muscarinic receptor antagonist single spray.
  • the spray kit comprises a phosphodiesterase 4 inhibitor single spray.
  • the spray assembly comprises a combined spray of a ⁇ 2 receptor agonist and a glucocorticoid.
  • the spray component comprises a combination spray of a ⁇ 2 receptor agonist and a muscarinic receptor antagonist.
  • the spray kit comprises a combined spray of a muscarinic receptor antagonist and a glucocorticoid.
  • the spray kit comprises a tripartite spray of ⁇ 2 receptor agonist, muscarinic receptor antagonist and glucocorticoid.
  • the ⁇ 2 receptor agonists include albuterol or a pharmaceutically acceptable salt thereof, fenoterol or a pharmaceutically acceptable salt thereof, terbutaline or a pharmaceutically acceptable salt thereof, formoste rol or its pharmaceutically acceptable salt, olodaterol or its pharmaceutically acceptable salt, arformoterol or its pharmaceutically acceptable salt, indacaterol or its pharmaceutically acceptable salt, vilanterol or its at least one of the pharmaceutically acceptable salts.
  • the pharmaceutically acceptable salt of salbutamol can be salbutamol sulfate and salbutamol hydrochloride.
  • the pharmaceutically acceptable salt of formoterol may be formoterol fumarate.
  • the pharmaceutically acceptable salt of olodaterol may be olodaterol hydrochloride.
  • the pharmaceutically acceptable salt of arformoterol may be arformoterol tartrate.
  • the pharmaceutically acceptable salt of indacaterol may be indacaterol maleate.
  • the pharmaceutically acceptable salt of vilanterol may be vilanterol triphenylacetate.
  • the glucocorticoids include fluticasone or a pharmaceutically acceptable salt or ester thereof, mometasone or a pharmaceutically acceptable salt or ester thereof, ciclesonide or a pharmaceutically acceptable salt or ester thereof, Clomethasone or a pharmaceutically acceptable salt or ester thereof, flunisolide or a pharmaceutically acceptable salt or ester thereof, budesonide or a pharmaceutically acceptable salt or ester thereof, triamcinolone acetonide or a pharmaceutically acceptable salt thereof or At least one of ester, dexamethasone, or a pharmaceutically acceptable salt or ester thereof.
  • the pharmaceutically acceptable salt of fluticasone may be fluticasone furoate or fluticasone propionate.
  • the pharmaceutically acceptable salt of mometasone may be mometasone furoate.
  • the pharmaceutically acceptable salt of beclomethasone can be beclomethasone dipropionate and beclomethasone dipropionate.
  • the pharmaceutically acceptable salt of dexamethasone can be dexamethasone sodium phosphate.
  • the muscarinic receptor antagonists include tiotropium or a pharmaceutically acceptable salt thereof, glycopyrronium or a pharmaceutically acceptable salt thereof, umeclidinium or a pharmaceutically acceptable salt thereof, uridine At least one of benzinium or a pharmaceutically acceptable salt thereof, ipratropium or a pharmaceutically acceptable salt thereof, oxitropium or a pharmaceutically acceptable salt thereof, revefenacin or a pharmaceutically acceptable salt thereof.
  • the pharmaceutically acceptable salt of tiotropium can be tiotropium bromide.
  • the pharmaceutically acceptable salt of glycopyrronium may be glycopyrronium bromide.
  • the pharmaceutically acceptable salt of umeclidinium can be umeclidinium bromide.
  • the pharmaceutically acceptable salt of umeclidinium can be umeclidinium bromide.
  • the pharmaceutically acceptable salt of ipratropium ammonium can be ipratropium bromide.
  • the pharmaceutically acceptable salt of oxitropium can be oxitropium bromide.
  • the phosphodiesterase 4 inhibitor comprises at least one of roflumilast or a pharmaceutically acceptable derivative thereof, apremilast or a pharmaceutically acceptable derivative thereof.
  • the pharmaceutically acceptable derivative of roflumilast can be roflumilast N-oxide.
  • the present invention also provides a spray assembly, including a spray and the aforementioned atomizer, and the active ingredient in the spray includes at least one of prostacyclin, treprostinil, and iloprost.
  • the present invention also provides a spray assembly, including a spray and the aforementioned atomizer, and the active ingredients in the spray include antibiotics or antiviral drugs.
  • the antibiotics include at least one of aztreonam, tobramycin, amikacin, and ciprofloxacin
  • the antiviral drugs include at least one of zanamivir, laninamivir, and ribavirin.
  • the present invention also provides a spray assembly, including a spray and the aforementioned atomizer, and the active ingredient in the spray includes at least one of pirfenidone and nintedanib.
  • the present invention also provides a spray assembly, including a spray and the aforementioned atomizer, and the active ingredients in the spray include small molecule cytotoxic drugs or biological agents.
  • the small molecule cytotoxic drugs include at least one of cisplatin, cyclophosphamide, etoposide, vinorelbine, and paclitaxel
  • the biological preparations include at least one of ipilimumab monoclonal antibody, nivolumab monoclonal antibody, and durvalumab monoclonal antibody. A sort of.
  • the present invention proposes the use of the aforementioned spray assembly in the preparation of a medicament for treating COPD (chronic obstructive pulmonary disease) and/or asthma.
  • COPD chronic obstructive pulmonary disease
  • the present invention proposes the use of the aforementioned spray assembly in the preparation of medicines for treating pulmonary hypertension.
  • the present invention proposes the use of the aforementioned spray assembly in the preparation of medicine for treating pulmonary infection.
  • the present invention proposes the use of the aforementioned spray assembly in the preparation of a drug for treating idiopathic pulmonary fibrosis.
  • the present invention proposes the use of the aforementioned spray assembly in the preparation of a drug for treating lung cancer.
  • the aforementioned spray assembly can be applied to the systemic administration of small molecule drugs such as levodopa and loxapine; it can also be used for the administration of biological agents such as insulin and insulin analogs, etc. Pulmonary systemic administration.
  • the present invention has the following advantages:
  • the atomizer airflow guide disclosed by the present invention includes a first pipe body and a second pipe body, wherein the first pipe body is provided with a first inlet, a first outlet and a connection between the first inlet and the first outlet.
  • the first guide passage, the second pipe body is provided with a second inlet, a second outlet, and a second guide passage communicating with the second inlet and the second outlet; and the end of the second pipe body is located at the first guide passage In a pipe body, the second outlet is located between the first inlet and the first outlet.
  • the second guiding channel is suitable for guiding the atomized particles into the first guiding channel
  • the first guiding channel is suitable for introducing external air, and using the external air to send the atomized particles into the oral cavity of the human body; and Because the flow path of the external air is to enter the first guide channel through the first inlet and flow out through the first outlet, the second outlet is located between the second interface of the first inlet and the first outlet, so that it enters the first guide channel through the second outlet.
  • the atomized particles in the guide channel are located on the circulation path of the external air, so that the atomized particles entering the first guide channel can be directly entrained by the external air and brought into the oral cavity of the human body.
  • the first inlet on the side wall of the first pipe body, it can also be located at the end of the first guide channel and opposite to the first outlet, combining the positional relationship between the first pipe body and the second pipe body , so that part of the external air forms a backflow due to collision with the side wall of the first pipe body and/or the second pipe body when flowing, and then the forward direction is adjusted so that the forward direction is close to parallel with the inner wall of the first pipe body to avoid fog
  • the retention of atomized particles is reduced, the residue of atomized particles is reduced, and the efficiency of drug administration is improved.
  • the present invention not only satisfies the assembly problem of the first pipe body, the second pipe body and the installation ring, but also makes the first pipe body and the second pipe body
  • the seal at the connection position of the body ensures the original characteristics of the airflow, thereby increasing the content of gas in the direction of deviation during advancement, improving the efficiency of drug delivery, and at the same time making the airflow guide have the functions of anti-fall and anti-disassembly.
  • the present invention also controls the entrance and exit area of the airflow guide and the height of the spray port to ensure that when spraying, at different inhalation volume flow rates, the deposition at the nozzle and the throat of the human body is less and the deposition amount is consistent.
  • Fig. 1 is a three-dimensional structural schematic diagram of an airflow guide of an atomizer in the present invention
  • Fig. 2 is the front view of Fig. 1;
  • Fig. 3 is the cross-sectional structure schematic diagram of Fig. 2;
  • Fig. 4 is a schematic cross-sectional structure diagram of an airflow guide
  • Fig. 5 is an exploded view of the structure of the atomizer in which the first pipe body and the second pipe body are integral parts in the present invention
  • Fig. 6 is a schematic diagram of the opening size of the first inlet 4.
  • Fig. 7 is a schematic cross-sectional structure diagram of a dimension of 4.6 mm from the end face position of the second outlet 7 to the reference plane of the mounting ring;
  • Fig. 8 is a schematic cross-sectional structure diagram of a dimension of 15.7mm from the position of the end face of the second outlet 7 to the reference plane of the mounting ring;
  • Fig. 9 is a schematic cross-sectional structure diagram of a dimension of 20.7 mm from the end face position of the second outlet 7 to the reference plane of the mounting ring;
  • Fig. 10 is a structural schematic diagram of the first inlet 4 at the end (opposite direction of the first inlet) and a mounting ring;
  • Fig. 11 is a structural schematic diagram of the first inlet 4 at the end (opposite direction of the first inlet), and no mounting ring;
  • Fig. 12 is a structural schematic diagram of the first inlet 4 on the side wall and the inlet angle of the inlet hole is inclined;
  • Fig. 13 is an exploded view of the structure of the first pipe body and the second pipe body in different separate parts according to the present invention. Explanation of reference signs:
  • connection should be understood in a broad sense, for example, it can be a fixed connection or a detachable connection, Or integrally connected; it may be mechanically connected or electrically connected; it may be directly connected or indirectly connected through an intermediary, and it may be the internal communication of two components.
  • installation should be understood in a broad sense, for example, it can be a fixed connection or a detachable connection, Or integrally connected; it may be mechanically connected or electrically connected; it may be directly connected or indirectly connected through an intermediary, and it may be the internal communication of two components.
  • the nebulizer flow guide provided in this embodiment includes a first tube body 1 , which is a straight tube and is mainly used for guiding water and communicating with the oral cavity of a human body.
  • the inner cavity of the first pipe body 1 is the first guide channel 6, the port at one end is the first outlet 5, and the side wall of the outer periphery of the other end is provided with a through hole for the first inlet 4.
  • the first pipe body 1 is suitable for guiding external air to flow into the first guide channel 6 from the first inlet 4 at the side wall of the straight tube, and flow out from the first outlet 5 at the end after being guided by the first guide channel 6 into the human mouth.
  • the first tube body 1 is generally used by mouth to realize communication with the oral cavity of the human body, and in order to match the natural opening shape of the oral cavity, the cross section of the first tube body 1 is generally oval.
  • the first tube body 1 is also provided with a raised portion 10 on the outer wall between the first inlet 4 and the first outlet 5 for indicating the maximum oral intake position.
  • the protruding part 10 may be point-shaped or arc-shaped, and in this embodiment it is an annular protrusion.
  • the atomizer flow guide provided in this embodiment also includes a second pipe body 2, which is an elbow with two ends open, and the inner cavity of the elbow is the second guide channel 8, and the two ports are respectively It is the second inlet 11 and the second outlet 7.
  • the curved shape of the second tube body 2 is suitable for adjusting the positional relationship between the medicine bottle and the oral cavity of the human body, so that when the nebulizer deflector is in a normal bite state, the medicine bottle body is in an upright state, which is preferred in this embodiment , the angle between the central axis of the second inlet 11 and the central axis of the second outlet 7 is 130°, of course, the angle can also be other values between 90°-150°.
  • the second inlet 11 is the inlet of the liquid medicine, with an area of 50mm 2 -300mm 2 .
  • the second inlet 11 is provided with an internal thread, and the internal thread is an adaptive connection between the second installation part 9 and the external thread at the mouth of the medicine bottle.
  • the second outlet 7 is an atomized particle outlet with an area of 100mm 2 -300mm 2 , specifically, the second outlet 7 is provided with a first installation part 12 suitable for installation with the atomization sheet, and passes through the first installation part 12 The atomizing sheet is installed, and then through the atomizing sheet, the liquid medicine is sprayed out through the second guiding channel 8 through the second outlet 7 and enters the first guiding channel 6 .
  • the first pipe body 1 and the second pipe body 2 are assembled and connected through the installation ring 3 , preferably, the first pipe body 1 , the second pipe body 2 and the installation ring 3 are integrally formed. Specifically, one side of the mounting ring 3 is connected to the end of the first pipe body 1, and the central hole is set on the outside of the second outlet 7 of the second pipe body 2, forming a connection between the second pipe body 2 and the first pipe body 1.
  • the connection relationship is such that the second outlet 7 is located in the first guide channel 6 and between the first inlet 4 and the first outlet 5 .
  • the height of the second outlet 7 The range is between the second interface and the third interface. Specifically, taking the boundary surface of the installation ring 3 close to the first inlet as the reference plane, the height from the second outlet 7 to the reference plane is greater than the height from the second interface of the first inlet 4 to the reference plane, and less than the height from the end surface of the first outlet 5 to the reference plane. The height of the datum.
  • the height range of the end face of the second outlet 7 is 4.6 mm to 20.7 mm, preferably, the height range of the second outlet 7 to the reference plane is 15.7 mm.
  • the second outlet 7 is located between the first inlet 4 and the first outlet 5, so that the second outlet 7
  • the atomized particles entering the first guiding channel 6 are located on the circulation path of the external air, so that the atomized particles entering the first guiding channel 6 can be directly entrained by the external air and brought into the oral cavity of the human body. It prevents the atomized particles from staying in the first guide channel 6 and then agglomerates, which improves the drug delivery efficiency.
  • the external gas pushes the atomized particles forward, so that the atomized particles are directed in the direction of the external gas, thereby realizing Precise control of the airflow direction of the atomized particles.
  • the airflow guide also has the following functions.
  • the connection position of the first pipe body 1 and the second pipe body 2 is realized.
  • the seal at the position allows external air to enter the first guide passage 6 only from the first inlet 4, so that the airflow guide has the functions of anti-drop damage and anti-demolition.
  • the deposition at the nozzle and the throat of the human body can be achieved under different suction volume flow rates during spraying few.
  • the first pipe body 1 and the second pipe body 2 are split structures, and the assembly connection is realized by optimizing the structures of the first pipe body 1 and the second pipe body 2 .
  • the inner wall of the first inlet 4 in the first pipe body 1 extends inwardly from the inner wall of the other end of the first outlet 5, and the installation platform and the inner wall of the first pipe body 1 form an annular assembly groove;
  • the first pipe body 1 and the second pipe body 2 can be connected by welding, snap-fit structure, screw locking structure or other methods. Fixed connection.
  • the present invention also provides an atomizer.
  • the atomizer also includes a housing 19 , a medicine bottle 20 and an atomization module.
  • the casing 19 is detachably connected to the outside of the airflow guide, not only serving as an installation platform to provide installation space, but also serving as a protective shell to protect the internal structure.
  • the detachable connection method is convenient for separating the airflow guide and the housing 19.
  • the housing 19 and the airflow guide are respectively provided with connection structures that can be detachably connected.
  • the connecting structure on the top can be set on the outside of the first pipe body 1 or the end of the installation ring 3. In this embodiment, it is preferable to set the connection between the installation ring 3 and the shell for fitting and detachment on the other side of the first pipe body 1 relative to the first pipe body 1. Section 13.
  • the medicine bottle 20 can be a medicine bottle that can be connected to the first installation part 12 when it leaves the factory, and can also be a medicine liquid packaging device that can be connected to the first installation part 12 with other bottle mouth specifications. Specifically, the medicine bottle 20 can be connected to the first installation part 12.
  • the sealing ring 18 is in detachable and sealing connection with the second inlet 11 .
  • the atomization module is a mesh atomization module, including an atomization sheet 16 .
  • the atomizing sheet 16 is installed in the second installation part 9 of the second outlet 7 through the first gasket 17, the second gasket 15 and the nozzle pressure plate 14, wherein the first gasket 17, the second gasket 15 and the nozzle pressure plate 14 are from the inside to the The outside is sequentially installed at the second outlet 7, the atomizing sheet 16 is clamped between the first gasket 17 and the second gasket 15; the nozzle pressure plate 14 is fixedly connected with the second pipe body 2 by welding.
  • the atomizing sheet is electrically connected with the drive structure, and is suitable for vibrating under the drive to atomize the liquid medicine;
  • the control switch of the drive structure is arranged on the housing, and is suitable for starting the drive structure through the switch.
  • this embodiment also discloses the use of the above atomizer:
  • the actual test results show that when the area ratio of the first inlet 4 and the first outlet 5 is 1:2.3, the liquid medicine in the nebulizer is in the nebulizer and simulates the suction port of the oropharynx of the human body. , The residue in the tapered mouth and the adapter is small, that is, the amount of atomized particles remaining in the nebulizer and the oropharynx of the human body is small.
  • the delivery efficiency is not affected by the flow rate of the atomized medicinal liquid, that is, it is not affected by the human lung capacity, thereby achieving an excellent inhalation effect; and the area ratio of the first inlet 4 and the first outlet 5 is 1:10, which is obviously 1:2.3 The data is slightly worse.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
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Abstract

Élément de guidage d'écoulement de gaz, nébuliseur, ensemble de pulvérisation et utilisation de l'ensemble de pulvérisation. L'élément de guidage d'écoulement de gaz comprend : un premier tube (1), le premier tube (1) étant pourvu d'une première entrée (4), d'une première sortie (5) et d'un premier canal de guidage (6), qui amène la première entrée (4) et la première sortie (5) à communiquer l'une avec l'autre ; et un second tube (2), le second tube (2) étant pourvu d'une seconde entrée (11), d'une seconde sortie (7) et d'un second canal de guidage (8), qui amène la seconde entrée (11) et la seconde sortie (7) à communiquer l'une avec l'autre, une extrémité du second tube (2) étant située dans le premier tube (1) et la seconde sortie (7) étant située entre la première entrée (4) et la première sortie (5). Le premier tube (1) et le second tube (2) peuvent être deux parties différentes et peuvent également être combinés en une partie intégrée. Au moyen d'une telle structure, il est possible d'empêcher des particules nébulisées de rester sur une paroi interne du premier canal de guidage (6) et ainsi de s'agglutiner, ce qui permet d'améliorer l'efficience de l'administration de médicament ; en outre, les particules nébulisées se trouvent dans la même direction qu'une direction d'avancement du gaz externe, ce qui permet de réguler avec précision la direction d'écoulement de gaz des particules nébulisées.
PCT/CN2022/142149 2021-12-28 2022-12-27 Nébuliseur et élément de guidage d'écoulement de gaz associé WO2023125471A1 (fr)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4484577A (en) * 1981-07-23 1984-11-27 Key Pharmaceuticals, Inc. Drug delivery method and inhalation device therefor
CN103041480A (zh) * 2011-10-12 2013-04-17 泰博科技股份有限公司 雾化装置及其喷头
CN105597200A (zh) * 2016-02-04 2016-05-25 深圳金亿帝医疗设备股份有限公司 雾化杯套件及压缩式雾化器
CN108295345A (zh) * 2018-03-22 2018-07-20 何德学 一种医疗雾化器
CN108472459A (zh) * 2016-08-31 2018-08-31 广东东阳光药业有限公司 一种倾斜流道式雾化器
CN213609045U (zh) * 2020-07-06 2021-07-06 深圳来福士雾化医学有限公司 一种多功能灵活便携式雾化装置

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4484577A (en) * 1981-07-23 1984-11-27 Key Pharmaceuticals, Inc. Drug delivery method and inhalation device therefor
CN103041480A (zh) * 2011-10-12 2013-04-17 泰博科技股份有限公司 雾化装置及其喷头
CN105597200A (zh) * 2016-02-04 2016-05-25 深圳金亿帝医疗设备股份有限公司 雾化杯套件及压缩式雾化器
CN108472459A (zh) * 2016-08-31 2018-08-31 广东东阳光药业有限公司 一种倾斜流道式雾化器
CN108295345A (zh) * 2018-03-22 2018-07-20 何德学 一种医疗雾化器
CN213609045U (zh) * 2020-07-06 2021-07-06 深圳来福士雾化医学有限公司 一种多功能灵活便携式雾化装置

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