WO2023125471A1

WO2023125471A1 - Nebulizer and gasflow guide member thereof

Info

Publication number: WO2023125471A1
Application number: PCT/CN2022/142149
Authority: WO
Inventors: 贺素敏; 林旭其; 曹立; 游劲松; 黄芳芳
Original assignee: 广东东阳光药业有限公司
Priority date: 2021-12-28
Filing date: 2022-12-27
Publication date: 2023-07-06

Abstract

A gasflow guide member, a nebulizer, a spraying assembly and the use of the spraying assembly. The gasflow guide member comprises: a first tube (1), the first tube (1) being provided with a first inlet (4), a first outlet (5), and a first guide channel (6), which makes the first inlet (4) and the first outlet (5) communicate with each other; and a second tube (2), the second tube (2) being provided with a second inlet (11), a second outlet (7), and a second guide channel (8), which makes the second inlet (11) and the second outlet (7) communicate with each other, wherein an end of the second tube (2) is located in the first tube (1), and the second outlet (7) is located between the first inlet (4) and the first outlet (5). The first tube (1) and the second tube (2) may be two different parts, and may also be combined into an integrated part. By means of such a structure, nebulized particles are prevented from staying on an inner wall of the first guide channel (6) and thus agglutinating, thereby improving the efficiency of medication delivery; in addition, the nebulized particles are in the same direction as an advancing direction of external gas, thereby accurately controlling the gasflow direction of the nebulized particles.

Description

An atomizer and its airflow guide

technical field

The invention belongs to the technical field of medical devices, and in particular relates to an airflow guide, an atomizer, a spray assembly and uses thereof.

Background technique

Nebulization inhalation for chronic obstructive pulmonary disease and asthma is the preferred method of administration recommended by relevant treatment guidelines. The nebulizer nebulizes the liquid medicine into an inhalable liquid with the aerodynamic particle size of most of the droplets being 1-5um. Drops, after oral inhalation, the drug can directly reach the lung lesion, so that the drug can fully produce local effects. The effect provided by this method is more efficient and direct than the general oral drug.

In the airflow guide of the existing nebulizer, the spray port is located at the end of the airflow auxiliary guide, and the lower auxiliary drainage opening is located on the side wall of the gas auxiliary guidance, and then the external air passes through the lower auxiliary drainage opening. The spray is introduced into the auxiliary guiding channel of the auxiliary air flow guide and pushes up the spray that enters the auxiliary guiding channel of the auxiliary air flow guide through the spray opening.

However, in the above structure, because the lower auxiliary drainage opening is located in the middle of the auxiliary guiding channel, not all the external air introduced into the auxiliary guiding channel due to negative pressure flows in the predetermined direction, and a small part of the external air will flow in the auxiliary guiding channel. The spray diffuses in the channel and collides with the spray, so that the spray accumulates in a large amount on the inner wall of the auxiliary guiding channel and forms residues, which makes it impossible to accurately control the atomized dosage of the nebulizer.

Contents of the invention

The purpose of the present invention is to provide an airflow guide, an atomizer, a spray assembly and its application, so as to solve the problem that the airflow guide of the nebulizer in the prior art cannot accurately control the nebulizer’s atomized dosage. The problem.

The atomizer airflow guide provided by the present invention includes: a first pipe body, on which a first inlet, a first outlet, and a first guide connecting the first inlet and the first outlet are arranged. Guide passage; second pipe body, the second pipe body is provided with a second inlet, a second outlet and a second guide passage communicating with the second inlet and second outlet; the end of the second pipe body The part is located in the first pipe body, and the second outlet is located between the first inlet and the first outlet.

According to the airflow guide of the atomizer mentioned above, the area ratio of the first inlet and the first outlet is 1:(1-10).

For the airflow guide of the atomizer mentioned above, it is further preferred that the area ratio of the first inlet and the first outlet is 1:(2-5). In some embodiments, the area ratio of the first inlet and the first outlet is 1:(1.8-2.3). In some embodiments, the area ratio of the first inlet and the first outlet is 1:(1.5-3). In some embodiments, the area ratio of the first inlet and the first outlet is 1:1.8. In some embodiments, the area ratio of the first inlet and the first outlet is 1:2.3. In some embodiments, the area ratio of the first inlet and the first outlet is 1:1, or 1:2, or 1:3, or 1:4, or 1:5, or 1:6, Or 1:7, or 1:8, or 1:9, or 1:10, or 1:11, or 1:12.

As mentioned above in the atomizer airflow guide, the second outlet end surface is located between the second interface of the first inlet and the first outlet end surface.

As for the airflow guide of the nebulizer as described above, it is further preferred that the first inlet is one or more, and is provided on the side wall of the first pipe body, or is provided at the end of the first guide passage and located in the opposite direction of the first outlet, the first inlet is a standard round, square or other special shape, the angle of the inlet is perpendicular to the side wall of the first pipe body, or other various inclined angles; the first outlet It is arranged at the end of the first pipe body.

For the airflow guide of the atomizer as described above, it is further preferred that the first inlet is multiple and surrounds the outer wall of the first tube body, or is located at the end of the first guide channel. The opposite reverse of the first exit.

For the airflow guide of the atomizer as described above, it is further preferred that the second inlet is provided with a first installation part, and the installation part is suitable for installing a medicine bottle; the second outlet is provided with a second installation part. part, the second installation part is suitable for installing the atomization module.

In the airflow guide for the nebulizer mentioned above, it is further preferred that the second outlet is provided with a second mounting portion which is a stepped hole, and the stepped hole is suitable for placing an atomizing component.

As for the airflow guide of the nebulizer as described above, it is further preferred that the mounting part of the second inlet is provided with a screw hole to facilitate the installation of a medicine bottle, and the second outlet is provided with a stepped hole to facilitate the installation of an atomizing sheet.

For the airflow guide of the atomizer mentioned above, it is further preferred that the area of the second inlet is 50mm ² -300mm ² , and the area of the second outlet is 100mm ² -300mm ² .

In the airflow guide for the atomizer described above, it is further preferred that the second pipe body is an elbow, and is suitable for making the angle between the central axis of the second inlet and the central axis of the second outlet 90°-150°.

The present invention also discloses an atomizer, which includes the airflow guide described in any one of the above.

The above-mentioned atomizer, further preferably, further includes: a housing, the housing is detachably connected to the outside of the airflow guide; an atomization module, including an atomization sheet, and the atomization sheet is installed on the The second outlet is suitable for contacting and connecting with the medicine bottle to vibrate and atomize the medicine liquid.

The atomizer as described above, further preferably, further includes a first gasket, a second gasket and a nozzle pressing plate, and the first gasket, the second gasket and the nozzle pressing plate are sequentially installed at the second outlet from the inside to the outside ; The atomizing sheet is clamped between the first gasket and the second gasket.

The present invention also provides a spray assembly, including spray and the aforementioned atomizer, the active ingredients in the spray are β2 receptor agonist, glucocorticoid, muscarinic receptor antagonist and phosphodiesterase At least one of the 4 inhibitors. In some embodiments, the spray kit comprises a β2-receptor agonist single spray. In some embodiments, the spray kit comprises a glucocorticoid single spray. In some embodiments, the spray kit comprises a muscarinic receptor antagonist single spray. In some embodiments, the spray kit comprises a phosphodiesterase 4 inhibitor single spray. In some embodiments, the spray assembly comprises a combined spray of a β2 receptor agonist and a glucocorticoid. In some embodiments, the spray component comprises a combination spray of a β2 receptor agonist and a muscarinic receptor antagonist. In some embodiments, the spray kit comprises a combined spray of a muscarinic receptor antagonist and a glucocorticoid. In some embodiments, the spray kit comprises a tripartite spray of β2 receptor agonist, muscarinic receptor antagonist and glucocorticoid.

In some embodiments, the β2 receptor agonists include albuterol or a pharmaceutically acceptable salt thereof, fenoterol or a pharmaceutically acceptable salt thereof, terbutaline or a pharmaceutically acceptable salt thereof, formoste rol or its pharmaceutically acceptable salt, olodaterol or its pharmaceutically acceptable salt, arformoterol or its pharmaceutically acceptable salt, indacaterol or its pharmaceutically acceptable salt, vilanterol or its at least one of the pharmaceutically acceptable salts. The pharmaceutically acceptable salt of salbutamol can be salbutamol sulfate and salbutamol hydrochloride. The pharmaceutically acceptable salt of formoterol may be formoterol fumarate. The pharmaceutically acceptable salt of olodaterol may be olodaterol hydrochloride. The pharmaceutically acceptable salt of arformoterol may be arformoterol tartrate. The pharmaceutically acceptable salt of indacaterol may be indacaterol maleate. The pharmaceutically acceptable salt of vilanterol may be vilanterol triphenylacetate.

In some embodiments, the glucocorticoids include fluticasone or a pharmaceutically acceptable salt or ester thereof, mometasone or a pharmaceutically acceptable salt or ester thereof, ciclesonide or a pharmaceutically acceptable salt or ester thereof, Clomethasone or a pharmaceutically acceptable salt or ester thereof, flunisolide or a pharmaceutically acceptable salt or ester thereof, budesonide or a pharmaceutically acceptable salt or ester thereof, triamcinolone acetonide or a pharmaceutically acceptable salt thereof or At least one of ester, dexamethasone, or a pharmaceutically acceptable salt or ester thereof. The pharmaceutically acceptable salt of fluticasone may be fluticasone furoate or fluticasone propionate. The pharmaceutically acceptable salt of mometasone may be mometasone furoate. The pharmaceutically acceptable salt of beclomethasone can be beclomethasone dipropionate and beclomethasone dipropionate. The pharmaceutically acceptable salt of dexamethasone can be dexamethasone sodium phosphate.

In some embodiments, the muscarinic receptor antagonists include tiotropium or a pharmaceutically acceptable salt thereof, glycopyrronium or a pharmaceutically acceptable salt thereof, umeclidinium or a pharmaceutically acceptable salt thereof, uridine At least one of benzinium or a pharmaceutically acceptable salt thereof, ipratropium or a pharmaceutically acceptable salt thereof, oxitropium or a pharmaceutically acceptable salt thereof, revefenacin or a pharmaceutically acceptable salt thereof. The pharmaceutically acceptable salt of tiotropium can be tiotropium bromide. The pharmaceutically acceptable salt of glycopyrronium may be glycopyrronium bromide. The pharmaceutically acceptable salt of umeclidinium can be umeclidinium bromide. The pharmaceutically acceptable salt of umeclidinium can be umeclidinium bromide. The pharmaceutically acceptable salt of ipratropium ammonium can be ipratropium bromide. The pharmaceutically acceptable salt of oxitropium can be oxitropium bromide.

In some embodiments, the phosphodiesterase 4 inhibitor comprises at least one of roflumilast or a pharmaceutically acceptable derivative thereof, apremilast or a pharmaceutically acceptable derivative thereof. The pharmaceutically acceptable derivative of roflumilast can be roflumilast N-oxide.

The present invention also provides a spray assembly, including a spray and the aforementioned atomizer, and the active ingredient in the spray includes at least one of prostacyclin, treprostinil, and iloprost.

The present invention also provides a spray assembly, including a spray and the aforementioned atomizer, and the active ingredients in the spray include antibiotics or antiviral drugs. The antibiotics include at least one of aztreonam, tobramycin, amikacin, and ciprofloxacin, and the antiviral drugs include at least one of zanamivir, laninamivir, and ribavirin.

The present invention also provides a spray assembly, including a spray and the aforementioned atomizer, and the active ingredient in the spray includes at least one of pirfenidone and nintedanib.

The present invention also provides a spray assembly, including a spray and the aforementioned atomizer, and the active ingredients in the spray include small molecule cytotoxic drugs or biological agents. The small molecule cytotoxic drugs include at least one of cisplatin, cyclophosphamide, etoposide, vinorelbine, and paclitaxel, and the biological preparations include at least one of ipilimumab monoclonal antibody, nivolumab monoclonal antibody, and durvalumab monoclonal antibody. A sort of.

According to one aspect of the present invention, the present invention proposes the use of the aforementioned spray assembly in the preparation of a medicament for treating COPD (chronic obstructive pulmonary disease) and/or asthma.

In some embodiments, the present invention proposes the use of the aforementioned spray assembly in the preparation of medicines for treating pulmonary hypertension.

In some embodiments, the present invention proposes the use of the aforementioned spray assembly in the preparation of medicine for treating pulmonary infection.

In some embodiments, the present invention proposes the use of the aforementioned spray assembly in the preparation of a drug for treating idiopathic pulmonary fibrosis.

In some embodiments, the present invention proposes the use of the aforementioned spray assembly in the preparation of a drug for treating lung cancer.

According to another aspect of the present invention, the aforementioned spray assembly can be applied to the systemic administration of small molecule drugs such as levodopa and loxapine; it can also be used for the administration of biological agents such as insulin and insulin analogs, etc. Pulmonary systemic administration.

Compared with the prior art, the present invention has the following advantages:

The atomizer airflow guide disclosed by the present invention includes a first pipe body and a second pipe body, wherein the first pipe body is provided with a first inlet, a first outlet and a connection between the first inlet and the first outlet. The first guide passage, the second pipe body is provided with a second inlet, a second outlet, and a second guide passage communicating with the second inlet and the second outlet; and the end of the second pipe body is located at the first guide passage In a pipe body, the second outlet is located between the first inlet and the first outlet. In the above structure, the second guiding channel is suitable for guiding the atomized particles into the first guiding channel, and the first guiding channel is suitable for introducing external air, and using the external air to send the atomized particles into the oral cavity of the human body; and Because the flow path of the external air is to enter the first guide channel through the first inlet and flow out through the first outlet, the second outlet is located between the second interface of the first inlet and the first outlet, so that it enters the first guide channel through the second outlet. The atomized particles in the guide channel are located on the circulation path of the external air, so that the atomized particles entering the first guide channel can be directly entrained by the external air and brought into the oral cavity of the human body. Staying in the first guide channel and agglomerating improves the efficiency of drug administration. On the other hand, the external air pushes the atomized particles forward, making the atomized particles take the direction of the external gas as the direction, thereby realizing the adjustment of the airflow direction of the atomized particles. precise control.

In the present invention, by arranging the first inlet on the side wall of the first pipe body, it can also be located at the end of the first guide channel and opposite to the first outlet, combining the positional relationship between the first pipe body and the second pipe body , so that part of the external air forms a backflow due to collision with the side wall of the first pipe body and/or the second pipe body when flowing, and then the forward direction is adjusted so that the forward direction is close to parallel with the inner wall of the first pipe body to avoid fog The retention of atomized particles is reduced, the residue of atomized particles is reduced, and the efficiency of drug administration is improved.

The present invention not only satisfies the assembly problem of the first pipe body, the second pipe body and the installation ring, but also makes the first pipe body and the second pipe body The seal at the connection position of the body ensures the original characteristics of the airflow, thereby increasing the content of gas in the direction of deviation during advancement, improving the efficiency of drug delivery, and at the same time making the airflow guide have the functions of anti-fall and anti-disassembly.

The present invention also controls the entrance and exit area of the airflow guide and the height of the spray port to ensure that when spraying, at different inhalation volume flow rates, the deposition at the nozzle and the throat of the human body is less and the deposition amount is consistent.

Description of drawings

In order to more clearly illustrate the specific implementation methods or technical solutions of the present invention, the accompanying drawings that need to be used in the specific implementation methods will be briefly introduced below. Obviously, the accompanying drawings in the following description are some implementation methods of the present invention. For Those of ordinary skill in the art can also obtain other drawings based on these drawings without making creative efforts.

Fig. 1 is a three-dimensional structural schematic diagram of an airflow guide of an atomizer in the present invention;

Fig. 2 is the front view of Fig. 1;

Fig. 3 is the cross-sectional structure schematic diagram of Fig. 2;

Fig. 4 is a schematic cross-sectional structure diagram of an airflow guide;

Fig. 5 is an exploded view of the structure of the atomizer in which the first pipe body and the second pipe body are integral parts in the present invention;

Fig. 6 is a schematic diagram of the opening size of the first inlet 4;

Fig. 7 is a schematic cross-sectional structure diagram of a dimension of 4.6 mm from the end face position of the second outlet 7 to the reference plane of the mounting ring;

Fig. 8 is a schematic cross-sectional structure diagram of a dimension of 15.7mm from the position of the end face of the second outlet 7 to the reference plane of the mounting ring;

Fig. 9 is a schematic cross-sectional structure diagram of a dimension of 20.7 mm from the end face position of the second outlet 7 to the reference plane of the mounting ring;

Fig. 10 is a structural schematic diagram of the first inlet 4 at the end (opposite direction of the first inlet) and a mounting ring;

Fig. 11 is a structural schematic diagram of the first inlet 4 at the end (opposite direction of the first inlet), and no mounting ring;

Fig. 12 is a structural schematic diagram of the first inlet 4 on the side wall and the inlet angle of the inlet hole is inclined;

Fig. 13 is an exploded view of the structure of the first pipe body and the second pipe body in different separate parts according to the present invention. Explanation of reference signs:

1-First pipe body, 2-Second pipe body, 3-Installation ring, 4-First inlet, 5-First outlet, 6-First guide channel, 7-Second outlet, 8-Second guide Guide channel, 9-second installation part, 10-protruding part, 11-second inlet, 12-first installation part, 13-connection part, 14-nozzle pressure plate, 15-second gasket, 16-atomizing sheet , 17-first gasket, 18-sealing ring, 19-housing, 20-medicine bottle.

Detailed ways

The technical solutions of the present invention will be clearly and completely described below in conjunction with the accompanying drawings. Apparently, the described embodiments are some of the embodiments of the present invention, rather than all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer" etc. The indicated orientation or positional relationship is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the referred device or element must have a specific orientation, or in a specific orientation. construction and operation, therefore, should not be construed as limiting the invention. In addition, the terms "first", "second", and "third" are used for descriptive purposes only, and should not be construed as indicating or implying relative importance.

In this description, it should be noted that, unless otherwise specified and limited, the terms "installation", "connection" and "connection" should be understood in a broad sense, for example, it can be a fixed connection or a detachable connection, Or integrally connected; it may be mechanically connected or electrically connected; it may be directly connected or indirectly connected through an intermediary, and it may be the internal communication of two components. Those of ordinary skill in the art can understand the specific meanings of the terms herein in specific situations.

As shown in FIGS. 1 to 4 , the nebulizer flow guide provided in this embodiment includes a first tube body 1 , which is a straight tube and is mainly used for guiding water and communicating with the oral cavity of a human body.

Specifically, the inner cavity of the first pipe body 1 is the first guide channel 6, the port at one end is the first outlet 5, and the side wall of the outer periphery of the other end is provided with a through hole for the first inlet 4. Further, the first There are multiple inlets 4, and the multiple first inlets 4 are arranged on the side wall of the straight pipe at circumferential intervals in an annular shape. The first pipe body 1 is suitable for guiding external air to flow into the first guide channel 6 from the first inlet 4 at the side wall of the straight tube, and flow out from the first outlet 5 at the end after being guided by the first guide channel 6 into the human mouth.

The first tube body 1 is generally used by mouth to realize communication with the oral cavity of the human body, and in order to match the natural opening shape of the oral cavity, the cross section of the first tube body 1 is generally oval. In addition, in order to avoid blocking the first inlet 4 during oral intake, the first tube body 1 is also provided with a raised portion 10 on the outer wall between the first inlet 4 and the first outlet 5 for indicating the maximum oral intake position. The protruding part 10 may be point-shaped or arc-shaped, and in this embodiment it is an annular protrusion.

The atomizer flow guide provided in this embodiment also includes a second pipe body 2, which is an elbow with two ends open, and the inner cavity of the elbow is the second guide channel 8, and the two ports are respectively It is the second inlet 11 and the second outlet 7. Specifically, the curved shape of the second tube body 2 is suitable for adjusting the positional relationship between the medicine bottle and the oral cavity of the human body, so that when the nebulizer deflector is in a normal bite state, the medicine bottle body is in an upright state, which is preferred in this embodiment , the angle between the central axis of the second inlet 11 and the central axis of the second outlet 7 is 130°, of course, the angle can also be other values between 90°-150°. The second inlet 11 is the inlet of the liquid medicine, with an area of 50mm ² -300mm ² . Specifically, the second inlet 11 is provided with an internal thread, and the internal thread is an adaptive connection between the second installation part 9 and the external thread at the mouth of the medicine bottle. , the second outlet 7 is an atomized particle outlet with an area of 100mm ² -300mm ² , specifically, the second outlet 7 is provided with a first installation part 12 suitable for installation with the atomization sheet, and passes through the first installation part 12 The atomizing sheet is installed, and then through the atomizing sheet, the liquid medicine is sprayed out through the second guiding channel 8 through the second outlet 7 and enters the first guiding channel 6 .

The first pipe body 1 and the second pipe body 2 are assembled and connected through the installation ring 3 , preferably, the first pipe body 1 , the second pipe body 2 and the installation ring 3 are integrally formed. Specifically, one side of the mounting ring 3 is connected to the end of the first pipe body 1, and the central hole is set on the outside of the second outlet 7 of the second pipe body 2, forming a connection between the second pipe body 2 and the first pipe body 1. The connection relationship is such that the second outlet 7 is located in the first guide channel 6 and between the first inlet 4 and the first outlet 5 . Taking the lowermost end of the first inlet 4 as the first interface, taking the edge of the first inlet 4 close to the first outlet 5 as the second interface, and taking the end face of the first outlet 5 as the third interface, the height of the second outlet 7 The range is between the second interface and the third interface. Specifically, taking the boundary surface of the installation ring 3 close to the first inlet as the reference plane, the height from the second outlet 7 to the reference plane is greater than the height from the second interface of the first inlet 4 to the reference plane, and less than the height from the end surface of the first outlet 5 to the reference plane. The height of the datum. Correspondingly, in this embodiment, the height range of the end face of the second outlet 7 is 4.6 mm to 20.7 mm, preferably, the height range of the second outlet 7 to the reference plane is 15.7 mm.

Because the flow direction of the external air is to enter the first guide channel 6 through the first inlet 4 and flow out through the first outlet 5, the second outlet 7 is located between the first inlet 4 and the first outlet 5, so that the second outlet 7 The atomized particles entering the first guiding channel 6 are located on the circulation path of the external air, so that the atomized particles entering the first guiding channel 6 can be directly entrained by the external air and brought into the oral cavity of the human body. It prevents the atomized particles from staying in the first guide channel 6 and then agglomerates, which improves the drug delivery efficiency. On the other hand, the external gas pushes the atomized particles forward, so that the atomized particles are directed in the direction of the external gas, thereby realizing Precise control of the airflow direction of the atomized particles.

At the same time, external air enters the first guide channel 6 from the first inlet 4 provided on the side wall of the first pipe body 1, and the second outlet 7 is located between the first inlet 4 and the first outlet 5, so that part of the The external air entering the first guide channel 6 from the first inlet 4 will collide with the side wall of the second pipe body 2, and then the direction of advancement will be adjusted. 7. The sprayed atomized particles meet and engulf the atomized particles in the area to advance, thereby reducing the residue of atomized particles and improving the drug delivery efficiency.

And because the first pipe body 1, the second pipe body 2 and the mounting ring 3 are integrally formed, the airflow guide also has the following functions. On the one hand, the connection position of the first pipe body 1 and the second pipe body 2 is realized. The seal at the position allows external air to enter the first guide passage 6 only from the first inlet 4, so that the airflow guide has the functions of anti-drop damage and anti-demolition.

By optimizing the height of the second outlet 7 in the airflow guide relative to the installation ring 3 and the area ratio of the first inlet 4 and the first outlet 5, the deposition at the nozzle and the throat of the human body can be achieved under different suction volume flow rates during spraying few.

In another embodiment of the present application, the first pipe body 1 and the second pipe body 2 are split structures, and the assembly connection is realized by optimizing the structures of the first pipe body 1 and the second pipe body 2 . Specifically, the inner wall of the first inlet 4 in the first pipe body 1 extends inwardly from the inner wall of the other end of the first outlet 5, and the installation platform and the inner wall of the first pipe body 1 form an annular assembly groove; There is an assembly ring extending outward from the outer wall of the second pipe body 2, and the assembly ring is adapted to connect with the assembly groove. The first pipe body 1 and the second pipe body 2 can be connected by welding, snap-fit structure, screw locking structure or other methods. Fixed connection.

Further, as shown in FIG. 5 , the present invention also provides an atomizer. In addition to the airflow guide mentioned above, the atomizer also includes a housing 19 , a medicine bottle 20 and an atomization module.

The casing 19 is detachably connected to the outside of the airflow guide, not only serving as an installation platform to provide installation space, but also serving as a protective shell to protect the internal structure. The detachable connection method is convenient for separating the airflow guide and the housing 19. In order to realize the detachable connection, the housing 19 and the airflow guide are respectively provided with connection structures that can be detachably connected. Specifically, the airflow guide The connecting structure on the top can be set on the outside of the first pipe body 1 or the end of the installation ring 3. In this embodiment, it is preferable to set the connection between the installation ring 3 and the shell for fitting and detachment on the other side of the first pipe body 1 relative to the first pipe body 1. Section 13.

The medicine bottle 20 can be a medicine bottle that can be connected to the first installation part 12 when it leaves the factory, and can also be a medicine liquid packaging device that can be connected to the first installation part 12 with other bottle mouth specifications. Specifically, the medicine bottle 20 can be connected to the first installation part 12. The sealing ring 18 is in detachable and sealing connection with the second inlet 11 .

The atomization module is a mesh atomization module, including an atomization sheet 16 . The atomizing sheet 16 is installed in the second installation part 9 of the second outlet 7 through the first gasket 17, the second gasket 15 and the nozzle pressure plate 14, wherein the first gasket 17, the second gasket 15 and the nozzle pressure plate 14 are from the inside to the The outside is sequentially installed at the second outlet 7, the atomizing sheet 16 is clamped between the first gasket 17 and the second gasket 15; the nozzle pressure plate 14 is fixedly connected with the second pipe body 2 by welding.

The atomizing sheet is electrically connected with the drive structure, and is suitable for vibrating under the drive to atomize the liquid medicine; the control switch of the drive structure is arranged on the housing, and is suitable for starting the drive structure through the switch.

Specifically, this embodiment also discloses the use of the above atomizer:

Install the medicine bottle containing the medicine solution on the second tube body 2, and install the shell on the outside of the first tube body 1; the medicine solution is drained into the second drainage channel through the second inlet 11, and reaches the second outlet 7 , start the atomization module through the control switch to atomize the liquid medicine in the second drainage channel, and the atomized particles through the atomization sheet at the second outlet 7 enter the middle of the first guiding channel 6; at the same time, the external air is The negative pressure enters the first guide channel 6 through the first inlet 4 and meets the atomized particles, thereby driving the atomized particles into the oral cavity.

1. Embodiments such as Fig. 1 and Fig. 8, based on the airflow guide of the above-mentioned mesh atomizer, the distance from the end face of the second outlet 7 to the reference plane of the mounting ring is 15.7mm, and the area of the first inlet 4 and the area of the first outlet 5 The ratios were 1:12; 1:5; 1:1.8. The following inhalation tests were carried out, and the specific data are as follows:

According to the test results of the above examples, it is known that when the volumetric flow rate is 28.3 L/min, when the area ratio of the first inlet 4 and the first outlet 5 changes from small to large, the liquid medicine in the nebulizer and the simulated The residues in the suction port, tapered mouth and adapter of the oropharynx of the human body are small, that is, the residual amount of atomized particles in the nebulizer and the oropharynx of the human body is small.

2. Embodiment As shown in Figure 13, when the area ratios of the first inlet 4 and the first outlet 5 are 1:2.3 and 1:10, the results of the suction test at different volume flow rates are shown in the table:

According to Figure 13 of the embodiment, the actual test results show that when the area ratio of the first inlet 4 and the first outlet 5 is 1:2.3, the liquid medicine in the nebulizer is in the nebulizer and simulates the suction port of the oropharynx of the human body. , The residue in the tapered mouth and the adapter is small, that is, the amount of atomized particles remaining in the nebulizer and the oropharynx of the human body is small. At the same time, the delivery efficiency is not affected by the flow rate of the atomized medicinal liquid, that is, it is not affected by the human lung capacity, thereby achieving an excellent inhalation effect; and the area ratio of the first inlet 4 and the first outlet 5 is 1:10, which is obviously 1:2.3 The data is slightly worse.

3. In addition, we also made a group of experimental tests on the ratio of the area of the first inlet to the surface of the first outlet of 1:2.3, and investigated the different values from the position of the end face of the second outlet 7 to the reference plane of the installation ring:

According to the above actual test results, it can be seen that when the distance from the end face of the second outlet 7 to the reference plane of the mounting ring is 4.6mm, the residual amount of atomization is more than that at 15.7mm and 20.7mm; when the end face of the second outlet 7 reaches When the distance value of the reference plane of the installation ring is in the range of 4.6mm (at this time, the end face of the second outlet 7 is flush with the second interface of the first inlet 4) to 20.7mm (the end face of the second outlet 7 is flush with the end face of the first outlet), (suction port + conical port + adapter) Residual % is decreasing.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the present invention, rather than limiting them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: It is still possible to modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the technical solutions of the various embodiments of the present invention. scope.

Claims

An atomizer airflow guide, characterized in that it comprises:

The first pipe body is provided with a first inlet, a first outlet, and a first guide channel communicating with the first inlet and the first outlet; the area of the first inlet 4 and the first outlet 5 The ratio is 1: (1-10);

The second pipe body is provided with a second inlet, a second outlet, and a second guide channel communicating with the second inlet and the second outlet; the second outlet end of the second pipe body The part is located in the first tube body.
The airflow guide for the atomizer according to claim 1, wherein the area ratio of the first inlet 4 and the first outlet 5 is 1:(2-5).
The airflow guide for the atomizer according to claim 1, wherein the second outlet end surface is located between the second interface of the first inlet and the first outlet end surface.
The airflow guide for the nebulizer according to claim 1, characterized in that, there are one or more first inlets, which are arranged on the side wall of the first pipe body, or on the first guide The end of the passage is located in the opposite direction of the first outlet, the first inlet is a standard circular, square or other special shape, and the angle of the inlet is perpendicular to the side wall of the first pipe body, or other various inclined angles; The first outlet is arranged at the end of the first pipe body.
The airflow guide for the atomizer according to claim 1, wherein there are multiple first inlets, which surround the outer wall of the first pipe body, or are located in the first guide channel. The end is located on the opposite side of the first outlet.
The airflow guide for the atomizer according to claim 1, wherein a first installation part is provided at the second inlet, and the installation part is suitable for installing a medicine bottle; The second installation part is suitable for installing the atomization module.
The airflow guide for the nebulizer according to claim 6, wherein the mounting part of the second inlet is provided with a screw hole for easy installation of a medicine bottle, and the second outlet is provided with a stepped hole for easy installation of an atomizer piece.
The airflow guide for the nebulizer according to claim 1, wherein the second pipe body is an elbow, which is suitable for making the center axis of the second inlet and the center axis of the second outlet The angle between them is 90°-150°.
An atomizer, characterized in that it comprises the atomizer airflow guide according to any one of claims 1-8.
The atomizer according to claim 9, further comprising:

a casing, the casing is detachably connected to the outside of the airflow guide;

The atomization module includes an atomization sheet installed at the second outlet, and is suitable for contacting the liquid medicine and vibrating to atomize the liquid medicine.
The atomizer according to claim 10, further comprising a first gasket, a second gasket and a nozzle pressure plate, the first gasket, the second gasket and the nozzle pressure plate are sequentially installed on the first gasket from inside to outside. Two outlets: the atomizing sheet is clamped between the first gasket and the second gasket.
A spray assembly, comprising spray and the atomizer according to claim 9, the active ingredients in the spray are β2 receptor agonist, glucocorticoid, muscarinic receptor antagonist and phosphodiesterase At least one of the 4 inhibitors.
The spray assembly according to claim 12, the β2 receptor agonist comprises albuterol or a pharmaceutically acceptable salt thereof, fenoterol or a pharmaceutically acceptable salt thereof, terbutaline or a pharmaceutically acceptable salt thereof , formoterol or a pharmaceutically acceptable salt thereof, olodaterol or a pharmaceutically acceptable salt thereof, arformoterol or a pharmaceutically acceptable salt thereof, indacaterol or a pharmaceutically acceptable salt thereof, vilan At least one of terol or a pharmaceutically acceptable salt thereof.
The spray assembly according to claim 12, the glucocorticoids include fluticasone or a pharmaceutically acceptable salt or ester thereof, mometasone or a pharmaceutically acceptable salt or ester thereof, ciclesonide or a pharmaceutically acceptable salt thereof or ester, beclomethasone or its pharmaceutically acceptable salt or ester, flunisolide or its pharmaceutically acceptable salt or ester, budesonide or its pharmaceutically acceptable salt or ester, triamcinolone acetonide or its pharmaceutically acceptable salt or ester At least one of acceptable salts or esters, dexamethasone or pharmaceutically acceptable salts or esters thereof.
The spray assembly according to claim 12, said muscarinic receptor antagonist comprises tiotropium or a pharmaceutically acceptable salt thereof, glycopyrronium or a pharmaceutically acceptable salt thereof, umeclidinium or a pharmaceutically acceptable salt thereof At least one of the salt of umeclidinium or a pharmaceutically acceptable salt thereof, ipratropium or a pharmaceutically acceptable salt thereof, oxygentropium or a pharmaceutically acceptable salt thereof, revefenacin or a pharmaceutically acceptable salt thereof .
The spray assembly according to claim 12, said phosphodiesterase 4 inhibitor comprising at least one of roflumilast or a pharmaceutically acceptable derivative thereof, apremilast or a pharmaceutically acceptable derivative thereof .
A use of the spray assembly described in any one of claims 12-16 in the preparation of a medicament for treating COPD and/or asthma.
A spray assembly, comprising a spray and the atomizer according to claim 9, wherein the active ingredient in the spray comprises at least one of prostacyclin, treprostinil and iloprost.
A use of the spray assembly according to claim 18 in the preparation of medicines for treating pulmonary arterial hypertension.
A spray assembly, comprising a spray and the atomizer according to claim 9, the active ingredients in the spray include antibiotics or antiviral drugs, and the antibiotics include aztreonam, tobramycin, amika At least one of star and ciprofloxacin, and the antiviral drug includes at least one of zanamivir, laninamivir and ribavirin.
A use of the spray assembly according to claim 20 in preparing medicine for treating pulmonary infection.
A spray assembly, comprising a spray and the atomizer according to claim 9, the active ingredient in the spray comprises at least one of pirfenidone and nintedanib.
A use of the spray assembly according to claim 22 in the preparation of medicines for treating idiopathic pulmonary fibrosis.
A spray assembly, comprising a spray and the nebulizer according to claim 9, the active ingredient in the spray is a small molecule cytotoxic drug or a biological agent.
A use of the spray assembly according to claim 24 in the preparation of medicines for treating lung cancer.