WO2023119624A1 - Capsule sans soudure - Google Patents

Capsule sans soudure Download PDF

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Publication number
WO2023119624A1
WO2023119624A1 PCT/JP2021/048197 JP2021048197W WO2023119624A1 WO 2023119624 A1 WO2023119624 A1 WO 2023119624A1 JP 2021048197 W JP2021048197 W JP 2021048197W WO 2023119624 A1 WO2023119624 A1 WO 2023119624A1
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WO
WIPO (PCT)
Prior art keywords
seamless capsule
seamless
contents
base material
sheet
Prior art date
Application number
PCT/JP2021/048197
Other languages
English (en)
Japanese (ja)
Inventor
達士 吉野
修 齋藤
理気 江夏
哲平 鎌田
Original Assignee
株式会社カマタ
株式会社アジア合同
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社カマタ, 株式会社アジア合同 filed Critical 株式会社カマタ
Priority to JP2022566451A priority Critical patent/JP7231796B1/ja
Priority to PCT/JP2021/048197 priority patent/WO2023119624A1/fr
Publication of WO2023119624A1 publication Critical patent/WO2023119624A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate

Definitions

  • the present invention relates to seamless capsules.
  • An object of one embodiment of the present invention is to provide a seamless capsule that releases a desired amount of contents within a predetermined period of time without applying an external factor such as crushing with fingers or teeth to the coating.
  • the present invention includes the following embodiment.
  • a coating containing a base material and a secondary material A seamless capsule having a content enclosed in the shell, The base material has a gelling function, The secondary material is a seamless capsule having a function of weakening gelation of the base material.
  • a seamless capsule that releases a desired amount of content within a predetermined period of time without applying an external factor such as crushing with fingers or teeth to the coating. can do.
  • Photographs showing how contents are released over time from the seamless capsules of Examples 1 and 2, and how the contents are not released over time from the seamless capsules of Comparative Example 1. is.
  • FIG. 1A a photograph taken immediately after removal from the storage container, a photograph taken 30 minutes after removal from the storage container, and a photograph taken 60 minutes after removal from the storage container. It is a figure which expands and shows the photograph image
  • 1 is a graph showing the time course of the total amount of contents released from seamless capsules according to Example 1, Example 2, and Comparative Example 1 (total amount of contents released).
  • a seamless capsule according to an embodiment is a seamless capsule having a coating containing a base material and a secondary material, and a content enclosed in the coating, wherein the base material has a gelling function and the secondary material is a seamless capsule that has the function of weakening the gelation of the base material.
  • a seamless capsule refers to a seamless capsule, ie, a seamless capsule.
  • the coating and the contents contained in the coating are collectively referred to as "capsule".
  • the seamless capsule according to this embodiment does not include rotary soft capsules, hard capsules, and tablet products.
  • the diameter of the seamless capsule is 0.5 mm or more and less than 20.0 mm, preferably 1.0 mm or more and less than 8.0 mm. not to be
  • the coating is a member that encloses the contents. By wrapping the contents in the film, it becomes possible to carry or store the contents in a state of being enclosed in the film.
  • the coating has a base material and a secondary material.
  • Base material A member having a gelling function is used as the base material.
  • the base material is gelled by containing moisture.
  • a gelled base encloses the contents.
  • a gelled substrate can also be referred to as a coating.
  • the film made of the gelled base material contains a secondary material that weakens the gelation of the base material.
  • the base material preferably contains, for example, at least one of agar, carrageenan, gelatin, sodium alginate, calcium lactate and pectin. According to these, the base material can be easily gelled by allowing the base material to contain moisture.
  • the base material may be composed of only agar, may be composed of only carrageenan, may be composed of only gelatin, or may be composed of only sodium alginate.
  • the base material may be composed of calcium lactate alone, the base material may be composed of pectin alone, or two or more of these may be used to constitute the base material. You may comprise a base material using the thing enumerated by and other members. In addition, even materials other than these can be used as materials for the base material, as long as they can be gelled by adding water to the base material and can achieve the purpose of the present embodiment. can be used.
  • a member having a function of weakening the gelation of the base material is used as the secondary material.
  • the present embodiment is characterized in that a member having a function of weakening the gelation of the base material is included in the gelled base material (that is, the film) as a secondary material.
  • the gelation of the base material is maintained so that the seamless capsule does not disintegrate due to the function of weakening the gelation of the secondary material, that is, the contents are not released from the seamless capsule.
  • Examples of storage in a state in which the gelation of the base material is maintained include storage in a storage solution in which the seamless capsule is placed in a container such as a bottle, wrapping in a damp cloth, etc., and storage in which the osmotic pressure is maintained. This includes storing it in a pristine condition.
  • An example of a preservative liquid includes water.
  • the secondary material preferably contains, for example, at least one of amino acids and polysaccharide thickeners. These materials can be preferably used because they have a function of weakening the gelation of the base material with respect to the base material using the above materials.
  • the secondary material may be composed of amino acids alone, the secondary material may be composed of polysaccharide thickener alone, or two or more of these may be used to configure the secondary material.
  • Sub-materials may be constructed using the listed materials and other materials. In addition, even materials other than these have not been used as a secondary material for a gelled base material (that is, a film), and have a function of weakening the gelation of the base material. Any material that can achieve the purpose of the embodiment can be used as a material for the secondary material.
  • amino acid is an organic compound that has both carboxyl and amino functional groups.
  • amino acids include glycine, glutamylvalylglycine, betaine, proline, hydroxyproline, glutamic acid, methionine, tryptophan, leucine, valine, phenylalanine, lysine, threonine (threonine), isoleucine, histidine, asparagine, aspartic acid, alanine, arginine. , glutamine, cysteine, serine, tyrosine, polyglutamic acid, cystine, and combinations of one or more of these.
  • thickening polysaccharides examples include acetylated adipic acid cross-linked starch, acetylated oxidized starch, acetylated phosphate cross-linked starch, sodium starch octenyl succinate, gati gum, curdlan, carboxymethylcellulose, carboxymethylcellulose calcium, carboxymethylcellulose sodium, xanthan gum.
  • guar gum glucono delta lactone, starch acetate, oxidized starch, gellan gum, ⁇ -cyclodextrin, ⁇ -cyclodextrin, ⁇ -cyclodextrin, tamarind seed gum, tara gum, dextrin, hydroxypropylated phosphate cross-linked starch, hydroxypropylcellulose , hydroxypropyl starch, hydroxypropyl methylcellulose, pullulan, methylcellulose, phosphoric acid cross-linked starch, phosphorylated starch, phosphoric acid monoesterified phosphoric acid cross-linked starch, locust bean gum, glucomannan, chitosan, inulin, and one or two of these Any combination of the above is included.
  • the seamless capsule according to the present embodiment can also be used for food if materials that can be added to food are used as the base material and secondary materials.
  • the content is a member enclosed in the coating.
  • the contents may be liquid, powder, solid, or a combination thereof.
  • the contents particularly preferably contain fats and oil-soluble substances.
  • the content may be composed only of fat and oil-soluble substance, or may contain other members in addition to fat and oil and oil-soluble substance.
  • fats and oils include coconut oil, vegetable oil, animal oil, and combinations thereof.
  • oil-soluble substances include fragrances, aromatic oils, menthol, and combinations thereof.
  • a seamless capsule that releases a desired amount of content within a predetermined period of time without applying an external factor such as crushing with fingers or teeth to the coating. can do.
  • the seamless capsule of the present embodiment can achieve a desired release amount within a predetermined period without applying an external factor such as crushing with fingers or teeth to the coating. It is configured to release its contents.
  • the seamless capsule of the present embodiment is completely different from conventional seamless capsules in the technical idea of how to release the contents from the seamless capsule.
  • the seamless capsule of the present embodiment can also be called a seamless capsule that disintegrates when exposed to the open air, or a seamless capsule that releases its contents when exposed to the open air. If the outside air is also regarded as one factor of external factors, the seamless capsule of the present embodiment can be said to be a seamless capsule that releases the contents without the addition of external factors other than the outside air.
  • the temperature of the outside air suitable for using the seamless capsule according to the present embodiment is, for example, a temperature higher than minus 20 degrees Celsius and lower than plus 60 degrees Celsius. is not particularly limited.
  • “Within a predetermined period” means, for example, within the expiration date of the seamless capsule. As shown in Examples 1 and 2 below, the predetermined period can be changed as appropriate by changing the weight ratio of the base material, moisture contained in the base material, secondary materials, contents, and the like. be.
  • the desired release amount may vary depending on the use of the seamless capsule. However, it is believed that the total amount of contents that a conventional seamless capsule releases within its expiration date is, at most, less than 1% of the total amount of contents. On the other hand, according to the present embodiment, it is possible to provide a seamless capsule in which the total amount of contents released within the expiration date of the seamless capsule is at least 1% or more of the total amount of the contents. .
  • the seamless capsule according to the embodiment differs from known production methods in that a secondary material is used in producing the shell.
  • the seamless capsules according to the embodiments can be produced in the same manner as known methods, except that secondary materials are used in producing the shell.
  • An example is as follows.
  • Step 1 First, the base material, secondary material, and water are mixed.
  • Step 2 Next, the mixture prepared in step 1 is heated. As a result, the base material and the secondary material are dissolved in water to prepare a coating liquid.
  • Step 3 using a concentric double nozzle, the film liquid prepared in step 2 is dropped together with the contents into the cooling oil, and the contents are encapsulated with the film.
  • Step 4 the seamless capsules produced in step 3 are stored while the gelation of the base material is maintained.
  • seamless capsules are stored in a storage container or the like containing a storage solution.
  • Example 1 has a shell weight of 35 mg (base material: 0.574 mg, water content: 28.686 mg, secondary material: 5.740 mg), and a liquid content weight: 30 mg.
  • the seamless capsule according to Example 2 has a shell weight of 35 mg (base material: 0.92 mg, water content: 27.63 mg, auxiliary material: 6.45 mg) and a liquid content weight of 30 mg.
  • the seamless capsule according to Comparative Example 1 has a shell weight of 35 mg (base material: 0.92 mg, water content: 34.08 mg) and a liquid content weight of 30 mg.
  • Example 1 In both Example 1, Example 2, and Comparative Example 1, agar is used as the base material, and medium-chain fatty acid triglyceride (MCT) is used as the content. However, in Examples 1 and 2, glycine is used as the secondary material, but in Comparative Example 1, no secondary material is used. In other words, Examples 1 and 2 differ from Comparative Example 1, which does not use secondary materials, in that secondary materials are used. Moreover, Examples 1 and 2 differ in the weight of the base material and the secondary material, but otherwise have the same configuration.
  • the seamless capsules produced in both Example 1, Example 2, and Comparative Example 1 are stored in a storage container containing water (an example of a preservative solution) immediately after production so that the gelation of the base material is maintained.
  • water an example of a preservative solution
  • Example 1 A plurality of seamless capsules according to Example 1, Example 2, and Comparative Example 1 were produced, and photographs and measurements were taken using these, which will be described below.
  • FIG. 1A shows how the contents are released over time from the seamless capsules according to Examples 1 and 2, and the contents are not released over time from the seamless capsule according to Comparative Example 1. It is a photograph showing a state.
  • the left column in FIG. 1A is a row of photographs taken of the seamless capsules according to Example 1
  • the central row in FIG. 1A is a row of photographs taken of the seamless capsules according to Example 2.
  • the row on the right side in FIG. 1A is a row of photographs of the seamless capsules according to Comparative Example 1.
  • the storage solution that adheres to the surface of the seamless capsules is applied.
  • FIG. 1B shows, among the photographs shown in FIG. 1A, a photograph taken immediately after removal from the storage container, a photograph taken 30 minutes after removal from the storage container, and a photograph taken 60 minutes after removal from the storage container.
  • FIG. 10 is a diagram showing an enlarged view of each of the photographs taken when the minutes have elapsed;
  • the seamless capsule according to Comparative Example 1 in which the coating does not contain secondary materials, does not release the contents over time, whereas the capsules of Examples in which the coating contains secondary materials.
  • the contents of the seamless capsules according to 1 and 2 are released over time.
  • the seamless capsule according to Example 2 releases more content over time than the seamless capsule according to Example 1.
  • a seamless capsule is prepared and placed in a storage container containing a storage solution.
  • 31 sheets are prepared and the weight of each sheet itself is weighed.
  • Kimwipe registered trademark manufactured by Kimberly-Clark is used as the sheet.
  • the size of each individual sheet is approximately 12.0 cm long by 10.75 cm wide.
  • a total of 31 sheets are obtained from the above.
  • the first sheet absorbs the contents released within 1 minute after the seamless capsule is placed on the first sheet.
  • the second sheet absorbs the contents released within 9 minutes after transferring the seamless capsule onto the second sheet.
  • the third and subsequent sheets absorb the contents released within 10 minutes after the seamless capsule is moved onto each sheet.
  • Table 1 shows the results for the seamless capsules according to Example 1
  • Table 2 shows the results for the seamless capsules according to Example 2
  • Table 3 shows the results for the seamless capsules according to Comparative Example 1.
  • the line "Weight of sheet (before weighing)” describes the weight of the sheet itself weighed in (2).
  • the weight of the sheet after absorbing the contents weighed in (9) is described in the row of "weight of sheet (after weighing)". All units are milligrams (mg).
  • the "1m” column corresponds to the first sheet, and the subsequent columns correspond to the second and subsequent sheets.
  • the "Sheet Weight (Before Weighing)” and “Sheet Weight (After Weighing)” rows respectively show the weight and contents of the fourth sheet itself.
  • the weight of the fourth sheet after absorption of is entered in the column "Weight of sheet (before weighing)" in the column "Immediately after”.
  • the weight of the first sheet after absorbing the contents is considered to be equal to the weight of the first sheet itself, and Entry of numerical values in is omitted.
  • the "release amount” row describes the difference between “sheet weight (after weighing)” and “sheet weight (before weighing)”.
  • the unit is milligram (mg).
  • “Amount Released” in column “1H” describes the difference between the weight of the 7th sheet after absorbing the contents and the weight of the 7th sheet itself.
  • the weight of the first sheet after absorbing the contents is considered to be equal to the weight of the first sheet itself, and the entry of the numerical value in the column "Amount released” in the column "Immediately after” is omitted.
  • the “total amount released” row in a certain column describes the sum of the “total amount released” in the previous column and the “released amount” in the corresponding column.
  • the unit is milligram (mg).
  • the "Total Emitted” in the “10m” column is the sum of the “Total Emitted” in the 1m column and the “Emitted” in the 10m column.
  • the total amount released is the total weight of the contents released from the 5 seamless capsules during the period from the removal of the storage solution from the surface of the seamless capsule in (3) until the time described in the first line ( In other words, it means the total value of the released amount).
  • the release amount in the column “20m” in Table 1 means the total amount of the contents released from the seamless capsule during 20 minutes after removing the preservative solution from the surface of the seamless capsule.
  • the weight of the first sheet after absorption of the contents is considered to be equal to the weight of the first sheet itself, and 0.00 mg is entered in the "total release amount" column in the "immediately after” column. entered.
  • FIG. 2 is a graph showing the time course of the total amount of contents released from seamless capsules according to Example 1, Example 2, and Comparative Example 1 (total amount of contents released).
  • the horizontal axis of FIG. 2 indicates the time that has elapsed since the preservative solution adhering to the surface of the seamless capsule was removed in step (3) above, and corresponds to the time described in the first row of Tables 1 to 3.
  • the vertical axis indicates the total amount of released contents, which corresponds to the numerical value described in the row of "Total Released Amount" in Tables 1 to 3.
  • the seamless capsule according to Comparative Example 1 in which the coating does not contain secondary materials, does not release the contents over time, whereas Examples 1 and 2 in which the coating contains secondary materials. Contents are released from the seamless capsule according to the present invention over time. In addition, the seamless capsule according to Example 2 releases more content over time than the seamless capsule according to Example 1.
  • Example 1 Example 1, Example 2, and Comparative Example 1 reveal the following.
  • the seamless capsule By including a secondary material having a function of weakening the gelation of the base material in the film, the seamless capsule can be released from the seamless capsule within a predetermined period without applying an external factor such as crushing with fingers or teeth to the film. It is possible to release a release amount of the contents. In other words, it is possible to naturally disintegrate the seamless capsule.
  • the predetermined period The period during which the contents are released from the seamless capsule
  • the amount of the contents released from the seamless capsule within the predetermined period referred to herein as the “desired "The amount of”.
  • the “total release amount” in Examples 1 and 2 above is an example of the “desired amount”.) can be controlled by adjusting the amount of the base material and / or secondary material can do. By controlling these periods and amounts, it becomes possible to release the contents from the seamless capsule in various modes depending on the use of the seamless capsule.
  • the capsules of the present embodiments and examples disintegrate when exposed to the outside air. No factor required.
  • the capsules of the present embodiments and examples disintegrate naturally or disintegrate autonomously.
  • the capsules of the present embodiment and examples are insoluble or difficult to dissolve in water or oil.
  • a capsule is, as seen in pharmaceuticals and health foods, the purpose of enclosing the liquid content for ingestion in a film (outer film) and releasing the contents when the film breaks down in the stomach and intestines when ingested. It is made as The method of disintegration of this film is caused by external factors such as body temperature, body moisture, and intestinal motility. In addition, there are also those that aim to disintegrate capsules in the oral cavity by increasing the disintegrating properties of the coating. Similarly, body temperature and body moisture cause capsule collapse. In addition, there are capsules that form a fragile film like those used in cigarettes and that disintegrate using external pressure, such as crushing the capsule with a finger to release the contents during use.
  • capsules The purpose of capsules is to make them easy to drink, easy to carry, and easy to use. Forms a film. Then, the contents are wrapped in a film when the capsule is molded, and then the moisture in the film is dried.
  • soft capsules By using soft capsules, it is possible to count the number of liquids that are originally difficult to weigh, and the portability is improved.
  • Some soft capsules are made by mixing oil and powder with an emulsifier. This also applies to orally disintegrating capsules. In the case of taking powder, there are so-called hard capsules, in which the powder is packed in an originally formed sheath. As with soft capsules, powders that are difficult to measure can be counted by the number of grains, improving portability.
  • capsules used for cigarettes, etc. use menthol and other refreshing substances and various flavored oils in the content liquid, and this capsule is built into the filter, so when smoking cigarettes, this capsule can be smoked by crushing it with your fingers. You can enjoy the refreshing feeling and different flavors in the smoke. Capsules also have anti-oxidant effects and envelop aromas and odors.
  • capsules have various purposes, but the capsules of the present embodiment and examples can be collapsed by external factors other than outside air (e.g. body temperature, body moisture, application of force, etc.). It is a capsule that does not need to dissolve in aqueous or oily liquids, or does not dissolve easily in water.
  • outside air e.g. body temperature, body moisture, application of force, etc.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)

Abstract

Capsule sans soudure ayant un revêtement contenant un substrat et un matériau secondaire, et des contenus qui sont enfermés par le revêtement, le substrat ayant une fonction de gélification, et le matériau secondaire ayant une fonction pour affaiblir la gélification du substrat.
PCT/JP2021/048197 2021-12-24 2021-12-24 Capsule sans soudure WO2023119624A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022566451A JP7231796B1 (ja) 2021-12-24 2021-12-24 シームレスカプセル及びその製法方法
PCT/JP2021/048197 WO2023119624A1 (fr) 2021-12-24 2021-12-24 Capsule sans soudure

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2021/048197 WO2023119624A1 (fr) 2021-12-24 2021-12-24 Capsule sans soudure

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WO2023119624A1 true WO2023119624A1 (fr) 2023-06-29

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PCT/JP2021/048197 WO2023119624A1 (fr) 2021-12-24 2021-12-24 Capsule sans soudure

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Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0925228A (ja) * 1995-07-13 1997-01-28 Eisai Co Ltd シームレスソフトカプセル
WO2000074720A1 (fr) * 1999-06-09 2000-12-14 Mochida Pharmaceutical Co., Ltd. Systeme de liberation dans les voies digestives inferieures
WO2003043609A1 (fr) * 2001-11-22 2003-05-30 Morishita Jintan Co., Ltd. Compositions de film pour capsules non gelatineuses et capsules utilisant celles-ci
JP2003299714A (ja) * 2002-04-10 2003-10-21 Fuji Capsule Kk 軟カプセル剤皮膜組成物
JP2004250369A (ja) * 2003-02-19 2004-09-09 Fuji Capsule Kk 軟カプセル剤皮膜組成物
WO2014170947A1 (fr) * 2013-04-15 2014-10-23 三生医薬株式会社 Capsule pouvant être écrasée, procédé de fabrication pour celle-ci et accessoire à fumer
WO2015052969A1 (fr) * 2013-10-07 2015-04-16 フロイント産業株式会社 Capsule sans soudure à base de plantes et son utilisation
JP2018108958A (ja) * 2016-12-28 2018-07-12 三生医薬株式会社 シームレスカプセル
JP2020115848A (ja) * 2019-10-11 2020-08-06 三生医薬株式会社 シ−ムレスカプセルならびにこれを含むフィルターおよび喫煙器具
WO2021210683A1 (fr) * 2020-04-17 2021-10-21 三生医薬株式会社 Capsule résistante à la chaleur et aliment/boisson la comprenant

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4249816B2 (ja) * 1997-02-24 2009-04-08 富士カプセル株式会社 ソフトカプセル

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0925228A (ja) * 1995-07-13 1997-01-28 Eisai Co Ltd シームレスソフトカプセル
WO2000074720A1 (fr) * 1999-06-09 2000-12-14 Mochida Pharmaceutical Co., Ltd. Systeme de liberation dans les voies digestives inferieures
WO2003043609A1 (fr) * 2001-11-22 2003-05-30 Morishita Jintan Co., Ltd. Compositions de film pour capsules non gelatineuses et capsules utilisant celles-ci
JP2003299714A (ja) * 2002-04-10 2003-10-21 Fuji Capsule Kk 軟カプセル剤皮膜組成物
JP2004250369A (ja) * 2003-02-19 2004-09-09 Fuji Capsule Kk 軟カプセル剤皮膜組成物
WO2014170947A1 (fr) * 2013-04-15 2014-10-23 三生医薬株式会社 Capsule pouvant être écrasée, procédé de fabrication pour celle-ci et accessoire à fumer
WO2015052969A1 (fr) * 2013-10-07 2015-04-16 フロイント産業株式会社 Capsule sans soudure à base de plantes et son utilisation
JP2018108958A (ja) * 2016-12-28 2018-07-12 三生医薬株式会社 シームレスカプセル
JP2020115848A (ja) * 2019-10-11 2020-08-06 三生医薬株式会社 シ−ムレスカプセルならびにこれを含むフィルターおよび喫煙器具
WO2021210683A1 (fr) * 2020-04-17 2021-10-21 三生医薬株式会社 Capsule résistante à la chaleur et aliment/boisson la comprenant

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