WO2023088400A1 - Liquid sample collection bottle, liquid sample collection device, and detection device - Google Patents
Liquid sample collection bottle, liquid sample collection device, and detection device Download PDFInfo
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- WO2023088400A1 WO2023088400A1 PCT/CN2022/132719 CN2022132719W WO2023088400A1 WO 2023088400 A1 WO2023088400 A1 WO 2023088400A1 CN 2022132719 W CN2022132719 W CN 2022132719W WO 2023088400 A1 WO2023088400 A1 WO 2023088400A1
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- Prior art keywords
- liquid sample
- sample collection
- bottle
- sampler
- wall
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- 238000001514 detection method Methods 0.000 title claims abstract description 75
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Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/52—Containers specially adapted for storing or dispensing a reagent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
- G01N2001/1472—Devices not actuated by pressure difference
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
- G01N2001/1472—Devices not actuated by pressure difference
- G01N2001/149—Capillaries; Sponges
Definitions
- the invention belongs to the technical field of medical devices, and further belongs to the field of medical testing, and in particular relates to a liquid sample collection bottle, a liquid sample collection device and a detection device.
- lateral flow immunoassay devices that can be used to detect the presence of analytes in samples, such as hormones, sugars, adulterants, drugs of abuse (including injecting or smoking drugs), etc.
- a liquid sample is collected and added to a lateral flow immunoassay device to detect a certain or certain components in the liquid sample.
- the liquid sample can be any volume of liquid for testing, inspection or research.
- the liquid sample can come from any liquid, such as body fluid, such as saliva or blood or urine or other liquids to be tested, such as water samples from pollution sources, liquid samples from beverages, etc.
- Liquid samples are typically collected and absorbed using a sampling stick having a collecting element formed of absorbent material such as a pad or sponge, which is attached to one end of a plunger.
- the collection element allows a sufficient volume of sample liquid to be absorbed from the liquid source, the presence of sample liquid in the collection element causing the interior of the collection element to expand.
- the collection element typically retains the sample until operation of the collection element releases the sample.
- the prior art usually squeezes the liquid sample out of the collection element of the sampling stick, and then adds it to the detection device (such as a lateral flow immunoassay device) for detection; or in some detections , It is also necessary to pretreat the extruded liquid sample with a buffer solution such as mixing/lysing, and then add it to the detection device for detection.
- the detection device such as a lateral flow immunoassay device
- the collection bottle is used to collect the liquid sample on the collection element, that is, the collection element end of the sampling rod is inserted into the collection bottle, and the collection element is pressed against the side wall or bottom of the collection bottle to make the liquid sample flow out into a collection bottle for sample collection.
- One of the objectives of the present invention is to provide a liquid sample collection bottle for collecting liquid samples of people or animals in view of the deficiencies in the prior art.
- a liquid sample collection bottle includes a bottle body, the bottle body includes an inner wall and an outer wall, and the inner wall includes a cylindrical part, wherein: the cylindrical part of the inner wall of the bottle is provided with guide rails that incline and spirally descend from top to bottom.
- the slope of the smooth curve decreases sequentially from top to bottom.
- the present invention also includes a backing plate placed in the bottle, and the backing plate is provided with through holes for the passage of liquid samples.
- the guide rail spirally descends one-sixth to one week of the inner wall of the bottle.
- a liquid sample collection device comprising a liquid sample collection bottle and a sampler
- the liquid sample collection bottle includes a bottle body
- the bottle body includes an inner wall and an outer wall
- the inner wall includes a cylindrical part
- the sampler includes a rod part and a liquid extraction part
- the liquid-absorbing part is connected to the lower end of the rod part
- the cylindrical part of the inner wall of the bottle is provided with a guide rail inclined from top to bottom and spirally descending
- the lower end of the rod part is provided with a guide groove
- the lower end of the rod part of the sampler is inserted into the liquid sample
- the guide groove at the lower end of the rod cooperates with the guide rail on the inner wall of the bottle to guide the lower end of the rod of the sampler to descend spirally in the liquid sample collection bottle.
- the cross-section of the guide rail on the inner wall of the bottle is rectangular, triangular, trapezoidal or arc-shaped, and the larger part of the guide rail cross-section is located on the inner wall of the bottle body.
- the guide rail is a smooth curve inclined from top to bottom.
- the backing plate and the dipping part of the sampler are provided with protrusions and depressions that cooperate with each other.
- the bottom of the dipping part is hardened so that it has a higher hardness compared to other parts of the dipping part, which is more conducive to reducing the bottom of the dipping part and the upper surface of the backing plate. slippage between.
- the guide rail spirally descends one-sixth to one week of the inner wall of the liquid sample collection bottle.
- the cooperating guide rails and guide grooves are a pair, or two, three, four, five or six pairs evenly distributed.
- the distance between the bottom of the guide rail and the upper surface of the backing plate is greater than or equal to 2.5 mm and less than or equal to 35.0 mm, and the lower end of the rod portion of the sampler can be snapped on the bottom of the guide rail.
- the lower surface of the bottom of the guide rail and the upper surface of the lower end of the rod of the sampler each include a slope parallel to each other. During the process of rotating the sampler in the forward direction, the pair of slopes further guides the The bottom presses down on the lower end of the stem of the sampler.
- the third object of the present invention is to provide a method for collecting liquid samples for collecting human or animal liquid samples in view of the deficiencies in the prior art.
- the sampler is reversely spiraled up, the sampler is taken out, and the liquid sample collection part is sealed.
- the liquid sample collection device is as disclosed in the second invention.
- the distance between the bottom of the guide rail on the inner wall of the liquid sample collecting part and the upper surface of the backing plate is greater than or equal to 2.5 mm and less than or equal to 35.0 mm; between the above steps C and D, when After the upper surface of the lower end of the rod portion of the sampler is lower than the bottom of the guide rail, the step of further rotating the sampler forwardly until the lower end of the rod portion of the sampler is buckled on the bottom of the guide rail is also included.
- the fourth object of the present invention is to provide a detection device for collecting liquid samples of humans or animals in view of the deficiencies of the prior art.
- a detection device comprising a liquid sample collection device and a detection plate
- the liquid sample collection device includes a liquid sample collection part and a sampler
- the liquid sample collection part includes a cylindrical inner wall
- the sampler includes a rod part and a liquid suction part
- the liquid-absorbing part is connected to the lower end of the rod part, wherein: the inner wall of the cylinder is provided with a guide rail inclined and spirally descending from top to bottom, and the lower end of the rod part is provided with a guide groove, and the lower end of the rod part of the sampler is inserted into the liquid sample collecting part
- the guide groove at the lower end of the rod cooperates with the guide rail on the cylindrical inner wall to guide the lower end of the rod of the sampler to spirally descend in the liquid sample collection part, and then twist or squeeze the liquid-absorbing part of the sampler.
- the detection board includes a detection plate. Component, the detection component is used to give the detection result information.
- the liquid sample collection component is mounted on the detection board or a component of the detection board.
- a guide rail inclined from top to bottom and spirally descending is arranged on the inner wall of the liquid sample collection bottle, and a guide groove is arranged at the lower end of the rod part of the sample.
- the lower end of the rod part of the guide sampler drives the liquid extraction part to perform a spiral downward movement in the sampling bottle, and then produces a squeezing effect similar to wringing a wet towel on the liquid absorption part, thereby fully Squeeze out the liquid sample drawn by the liquid absorbing part.
- the present invention has a higher liquid sample extrusion rate, and can squeeze out more liquid samples for detection when the same liquid sample is drawn by the suction part, so that it is easier to meet the detection requirements.
- the minimum amount of liquid samples thereby improving the success rate of detection and the accuracy of detection results.
- Fig. 1 is a schematic plan view of a liquid sample collection bottle of the present invention.
- FIG. 2 is a schematic cross-sectional view along line A-A of FIG. 1 .
- Fig. 3 is a schematic plan view of the backing plate in the liquid sample collection bottle of the present invention.
- FIG. 4 is a top view of FIG. 1 .
- FIG. 6 is a schematic partial cross-sectional view along the line A-A of FIG. 5 .
- Figure 7 is similar to Figure 5, but with the sampler inserted into the liquid sample collection bottle in its initial position (the dip has not been squeezed).
- FIG. 8 is a schematic cross-sectional view along line A-A of FIG. 7 .
- FIG. 9 is a partially enlarged view of part "A" in FIG. 8 .
- 10-12 are schematic diagrams of modified designs of FIG. 9 .
- Fig. 13 is a partially developed plan view of the cylindrical part of the inner wall of the liquid sample collection bottle of the present invention.
- FIG. 14 is a schematic diagram of a modified design of FIG. 13 .
- Figure 15 is similar to Figure 7, but with the sampler inserted into the final position in the liquid sample collection bottle (with the dip fully squeezed).
- Fig. 16 is a schematic cross-sectional view along the line A-A of Fig. 15 .
- FIG. 17 is a schematic diagram of a modified design of FIG. 16 .
- FIG. 18 is an enlarged schematic view of part “B” in FIG. 17 .
- Fig. 19 is another partial angular sectional view of the cooperation between the guide rail on the liquid sample collection bottle and the lower part of the sampler.
- Fig. 21 is similar to Fig. 8, showing another modified design of the present invention.
- FIG. 22 is an enlarged schematic view of part “C” in FIG. 21 .
- FIG. 23 is a modified design diagram of FIG. 22 .
- 24-29 are six specific embodiments of the cooperation between the guide rail and the guide groove of the liquid sample collection device of the present invention.
- Fig. 30 is a schematic diagram of the use state of the detection device of the present invention.
- FIG. 31 is a schematic diagram of the detection results of the detection board shown in FIG. 30 .
- FIG. 33 is a schematic diagram of the detection results of the detection board shown in FIG. 32 .
- the cylinder of the present invention refers to a hollow cylinder or hollow barrel whose cross-section is circular or approximately circular, and the areas of each cross-section are equal or approximately equal; the cylinder of the present invention also includes cut Hollow cone with truncated apex, that is, the longitudinal section through its axis is an isosceles trapezoid or approximately isosceles trapezoid, but the angle between the hypotenuse and the height of the trapezoid is preferably not more than fifteen degrees, but Nor is it limited to fifteen degrees.
- the hollow column or hollow cone that achieves the beneficial effects of the present invention are all included in the cylinder of the present invention. In the range.
- Liquid sample collection bottle also known as a liquid sample collection part, refers to a bottle-shaped object, a cup-shaped object, a cylindrical object, and any shape or part of an object with a cylindrical inner wall for collecting liquid samples.
- Spiral descent also known as spiral descent, that is, on the inner wall of the cylinder, it gradually descends in the form of a spiral from a high place to a low place, forming a three-dimensional smooth curve trajectory.
- the spiral can be from a fraction of a turn to a turn or several turns.
- Rectangle, triangle, trapezoid including not only the rectangle, triangle, and trapezoid in mathematical concepts, but also the approximate rectangle, triangle, and trapezoid.
- Forward refers to the direction opposite to the reverse, but forward does not specifically refer to the clockwise direction, but refers to one of the clockwise or counterclockwise directions.
- the reverse direction refers to the counterclockwise direction; otherwise, when the forward direction refers to the counterclockwise direction, the reverse direction refers to the clockwise direction.
- Squeeze Squeeze while twisting, that is, the two ends of the object rotate in opposite directions when they are close to each other, producing an effect similar to wringing a wet towel.
- the present invention provides a liquid sample collection bottle 10, which is used to collect liquid samples such as saliva, blood, urine, sweat, etc. (including immunological detection methods and non-immunological detection methods) to detect the content of a certain substance or substances in these liquid samples, so as to obtain the physiological parameter indicators of the tested human body or animal.
- liquid samples such as saliva, blood, urine, sweat, etc.
- immunological detection methods and non-immunological detection methods to detect the content of a certain substance or substances in these liquid samples, so as to obtain the physiological parameter indicators of the tested human body or animal.
- coronavirus pneumonia Taking the detection of new coronavirus pneumonia as an example, scientists have developed products and detection methods that use human or animal saliva (including processed) as samples to determine whether the human body or animal that provided the saliva sample is infected with the new coronavirus. Coronavirus pneumonia.
- One of the important links of the detection method is how to collect the saliva of the human body or animal to be tested.
- the object of the present invention is to provide a novel liquid sample collection bottle for collecting human or animal saliva, a liquid sample collection device, a detection device, and a method for collecting liquid samples using the liquid sample collection device.
- the invention can be used for the detection of novel coronavirus pneumonia.
- Invention 1 Liquid sample collection bottle
- the liquid sample collection bottle 10 of the present invention comprises a bottle body 12, and the bottle body 12 includes an inner wall 14 and an outer wall 16, and the inner wall 14 includes a cylindrical portion 18 (that is, at least a part of the inner wall 14 is a cylinder) structure), the cylindrical part 18 is provided with a guide rail 20 that inclines and descends spirally from top to bottom.
- the guide rail 20 protrudes from the inner wall 14 to the centerline of the cylinder for an appropriate distance, and is attached to the inner wall 14 as a helical disc. Please refer to Fig.
- the cross-section of the guide rail 20 is rectangular (including square), triangular, trapezoidal or arc-shaped (including part circular or part oval), and the larger part of the cross-section of the guide rail 20 (As shown by the dotted lines in FIGS. 9-12 ) located on the inner wall 14 of the bottle body 12 (that is, in the direction from the inner wall 14 to the centerline of the cylinder, the cross-sectional dimensions of the guide rails 20 are equal or gradually smaller).
- the guide rail 20 on the inner wall 14 is in an inclined straight line from top to bottom.
- the included angle "A" between the inclined straight line and the horizontal plane is greater than or equal to 30 degrees and less than or equal to 75 degrees, and the preferred included angle "A” is 60 degrees and 45 degrees.
- the guide rail 20 on the inner wall 14 is in the shape of an inclined smooth curve from top to bottom. The slope of the smooth curve decreases successively (that is, the angle between the tangent of the smooth curve and the horizontal plane decreases gradually).
- the liquid sample collection bottle 10 further includes a backing plate 22 placed in the bottle body 12 .
- the backing plate 22 is provided with several through holes 24 to facilitate the flow of liquid samples.
- the backing plate 22 is in the shape of a disc with a thickness of about 2.0-5.0 mm and is usually made of hard plastic.
- the bottle body 12 includes an upper part and a lower part. The size of the upper part is obviously larger than that of the lower part.
- a shoulder 26 is formed at the junction of the two parts. The backing plate 22 is placed on and supported by the shoulder 26 .
- FIG. 3 is a top plan view of the backing plate 22
- FIG. 4 is a top plan view of the backing plate 22 after being placed in the bottle body 12 .
- a depression 30 (as shown in FIG. 22 , the depression may also be a through hole 24 as shown in FIG. 3 ) or a protrusion 28 (as shown in FIG. 23 ) is provided on the upper surface of the backing plate 22 .
- the present invention also provides a liquid sample collection device 100, which includes the liquid sample collection bottle 10 as described in the first invention (in order to avoid repetition, the content in the first invention All are incorporated into the second invention, and the specific structure of the liquid sample collection bottle 10) and the sampler 50 will not be described in detail in the second invention.
- the sampler 50 includes a stem 52 and a dip 56 connected to a lower end 54 of the stem.
- the liquid-absorbing part 56 is made of a material with excellent water absorption and drainage properties, such as sponge, absorbent cotton, gauze, special fiber and the like.
- Rod 52 is made of hard material, and the lower end 54 of the rod is disc-shaped, and its periphery is provided with guide groove 58, and the shape and size of this guide groove 58 are corresponding to guide rail 20 on the bottle inner wall 14 (Fig. 5 and The guide groove 58 shown in Figure 6 is inclined, and the direction of inclination is consistent with the guide rail 20), the size of the bar lower end 54 is adapted to the space surrounded by the bottle inner wall 14, so that even the guide rail 20 can move in the guide groove 58, the guide rail 20 and the guide groove 58 can cooperate with each other to play the role of guiding the lower end 54 of the rod portion to spiral down.
- the guide groove 58 of the rod lower end 54 cooperates with the guide rail 20 on the bottle inner wall 14, and the rod lower end 54 of the guide sampler 50 is in the Spiral descending inside liquid sample collection bottle.
- the surface friction between the two reduces the relative sliding of the bottom of the dipping portion 56 relative to the pad portion 22, while the guide rail 20 guides the lower end 54 of the stem portion.
- the liquid sample is discharged from the drawing part 56 into the liquid sample collection bottle 10, and mixed with the lysate 60 in the collection bottle (as shown in FIG. 8 ) to form a mixed solution 62 of the lysate and the liquid sample (as shown in FIG. 16 ).
- the guide rail 20 on the inner wall 14 is in the shape of an inclined straight line or a smooth curve from top to bottom.
- the smooth curved guide rail is beneficial to the guide rail 20 and the guide groove 58 to guide the lower end 54 of the rod part to accelerate the descending speed at the beginning of the descending stage, thereby exerting a stronger downward extrusion on the liquid extraction part, while in the When approaching the end of the descent, the guide rail 20 and the guide groove 58 guide the lower end 54 of the rod part to produce a stronger twist, thereby producing a better wringing effect on the liquid drawing part 56, and squeezing out more liquid samples from the liquid drawing part 56 .
- the upper surface of the backing plate 22 and the bottom of the liquid absorbing portion 56 of the sampler are provided with mutual cooperation.
- the protrusions 28 and the depressions 30 cooperate with each other to reduce the relative slippage between the bottom of the dipping part 56 and the upper surface of the backing plate 22, and enhance the wringing effect on the dipping part 56.
- the distance "L” between the bottom of the guide rail 20 and the upper surface of the backing plate 22 is greater than or equal to 2.5 millimeters and less than or equal to 35.0 millimeters, and this distance “L” can make the rod portion of the sampler 50
- the lower end 54 is buckled on the bottom of the guide rail 20 (as shown in FIGS. 17 and 18 ).
- the advantage of such a design is that the liquid-absorbing part 56 can still be kept in a twisted and compressed state after the operator lets go.
- the lower surface of the bottom of the guide rail 20 and the upper surface of part of the lower end 56 of the rod portion of the sampler 50 are a pair of inclined surfaces 32 and 34 that cooperate with each other.
- the pair of inclined surfaces have a guiding effect, and make the bottom of the guide rail 20 further press the lower end 54 of the rod portion of the sampler 50 downward. , still make the lower end of the rod portion of the sampler be squeezed by the bottom of the guide rail 20 after the operator lets go.
- Invention 3 A method for collecting liquid samples
- the present invention also provides a method for collecting a liquid sample.
- the method provides the liquid sample collecting part 10 and the sampler 50 as disclosed in the first and second inventions above.
- the guide mechanism for spiral descent is used to guide the sampler 50 to descend spirally in the liquid sample collection part 10 .
- the method comprises the steps of:
- the sampler 50 is spiraled upward in reverse, the sampler 50 is taken out, and the liquid sample collection bottle 10 is sealed.
- FIG. 30 and 31 show the use status and detection results of a detection device of the present invention.
- the detection device 200 includes a liquid sample collection device 100 (the structure is as described in "Invention 2", the difference is that a cap 11 is added) and a detection plate 210 .
- the liquid sample collection device 100 comprises a liquid sample collection part 10 and a sampler 50 (the sampler 50 is omitted in FIG. , the dipping portion 56 is connected to the lower end 54 of the rod portion.
- the cylindrical inner wall 14 is provided with a guide rail 20 inclined from top to bottom and spirally descending, and the lower end 54 of the rod part is provided with a guide groove 58 inclined in the same direction as the guide rail 20 .
- the liquid sample collecting part 10 is mounted on the detection board 210 or a certain part of the detection board 210 .
- the liquid sample collection part 10 and the detection board 210 or a certain part of the detection board 210 can be manufactured separately and then assembled together, or can be integrally formed with the detection board 210 or a certain part of the detection board 210 and then assembled together , forming a whole.
- the cylindrical inner wall 14 of the liquid sample collecting part 10 is provided with a guide rail 20 inclined and spirally descending from top to bottom.
- the lower end 54 of the rod portion is provided with a guide groove 58 inclined in the same direction as the guide rail 20 .
- the guide groove 58 at the lower end of the rod part cooperates with the guide rail 20 on the inner wall of the cylinder to guide the lower end 54 of the rod part of the sampler to descend spirally in the liquid sample collecting part 10. , and then wring or extrude the dipping portion 56 of the sampler.
- the basic principle and specific structure are as disclosed in "Invention 2".
- the present invention uses a sponge stick as an example of the sampler 50 to collect human saliva, and uses the method of comparative experiment to check the beneficial effects of the present invention.
- Step 1 Use the sponge sticks of the 10 fundamental inventions to be numbered 1-10 in sequence, and use an electronic scale accurate to one-thousandth of a gram to weigh the weight of each sponge stick before drawing liquid, and record it in "A” in the table below " column (the unit of weight is grams, the same below);
- Step 3 Insert the above 10 sponge sticks into the existing liquid sample collection bottles, squeeze the sponge head vertically, fully squeeze out the saliva on the sponge head, and weigh the sponge head respectively , recorded in column "C" in the table below;
- Step 5 use the formula in the following table to calculate respectively the amount of liquid drawn (E) of these 10 sponge sticks, the sample extrusion amount (F) using the existing method, and the sample extrusion amount (G) using the method of the present invention. ), adopt the sample extrusion percentage (H) of existing method, adopt the sample extrusion percentage (I) of the method of the present invention and the present invention improve percentage (J) relative to present method.
- the sampling amount of the sampling method of the present invention is improved by 31.30% on average compared with the current sampling method. This experiment shows that the beneficial effects of the sampling device and sampling method of the present invention are very prominent.
- the sample collection bottle of the present invention cooperates with the sampling stick to fully collect the samples in the sampling stick, and can simultaneously complete the pretreatment steps such as sample cracking.
- pretreatment steps such as sample cracking.
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Abstract
A liquid sample collection bottle (10), a liquid sample collection device (100), and a detection device (200). The liquid sample collection device (100) comprises the liquid sample collection bottle (10) and a sampler (50), wherein an inner wall (14) of the liquid sample collection bottle (10) is provided with a guide rail (20) inclined from top to bottom and descending spirally, and a rod part lower end (54) of the sampler (50) is provided with a guide groove (58). After the rod part lower end (54) of the sampler (50) is inserted into the liquid sample collection bottle (10), the guide groove (58) at the rod part lower end (54) and the guide rail (20) on the inner wall (14) of the bottle body work in conjunction to guide the rod part lower end (54) of the sampler (50) to spirally descend in the liquid sample collection bottle (10), and then a liquid drawing part (56) of the sampler (50) is squeezed.
Description
本发明属于医疗器械技术领域,进一步属于医学检验领域,尤其是涉及一种液体样本收集瓶、液体样本收集装置及检测装置。The invention belongs to the technical field of medical devices, and further belongs to the field of medical testing, and in particular relates to a liquid sample collection bottle, a liquid sample collection device and a detection device.
有多种临床侧流免疫分析装置可用于检测样本中分析物的存在,如激素、糖、掺杂物、滥用药物(包括注射或者吸食毒品)等。通常采集液体样本并将其添加到侧流免疫分析装置后对液体样本中的某种或者某些成份进行检测。There are a variety of clinical lateral flow immunoassay devices that can be used to detect the presence of analytes in samples, such as hormones, sugars, adulterants, drugs of abuse (including injecting or smoking drugs), etc. Usually, a liquid sample is collected and added to a lateral flow immunoassay device to detect a certain or certain components in the liquid sample.
其中,液体样本可以是进行测试、检查或研究的任何体积的液体。液体样本可以来源于任何液体,例如体液,如唾液或血液或尿液或其他待测液体,如来自污染源的水样、来自饮料的液体样本等。Wherein, the liquid sample can be any volume of liquid for testing, inspection or research. The liquid sample can come from any liquid, such as body fluid, such as saliva or blood or urine or other liquids to be tested, such as water samples from pollution sources, liquid samples from beverages, etc.
通常采用采样棒对液体样本进行收集吸收,该采样棒具有由吸收材料如垫或海绵形成的收集元件,收集元件连接到柱塞的一端。收集元件使得可以从液体源吸收足够体积的样本液体,收集元件中样本液体的存在导致收集元件内部膨胀。收集元件通常保持样本,直到操作收集元件释放样本。检测时,现有技术通常是采用挤压的方式将液体样本从采样棒的收集元件上挤脱出来,然后再添加到检测装置(例如侧流免疫分析装置)上进行检测;或者在有些检测中,还需要将挤脱出来的液体样本先与缓冲溶液进行混合/裂解等预处理,然后再添加到检测装置上进行检测。Liquid samples are typically collected and absorbed using a sampling stick having a collecting element formed of absorbent material such as a pad or sponge, which is attached to one end of a plunger. The collection element allows a sufficient volume of sample liquid to be absorbed from the liquid source, the presence of sample liquid in the collection element causing the interior of the collection element to expand. The collection element typically retains the sample until operation of the collection element releases the sample. During detection, the prior art usually squeezes the liquid sample out of the collection element of the sampling stick, and then adds it to the detection device (such as a lateral flow immunoassay device) for detection; or in some detections , It is also necessary to pretreat the extruded liquid sample with a buffer solution such as mixing/lysing, and then add it to the detection device for detection.
现有的操作中,使用收集瓶对收集元件上的液体样本进行收集,即将采样棒的收集元件端插入收集瓶中,将收集元件接触收集瓶体的侧壁或底部进行挤压使液体样本流出到收集瓶中进行样本收集。现有的收集瓶和采样棒存在的问题是,不能将采样棒之收集元件上的液体样本充分地挤压出来,即在挤压后,收集元件上仍然残留着较多的液体样本,从而仅有较少的液体样本用于后续的检测,因而很容易造成用于检测的液体样本量不够,从而造成检测失败或者检测结果不准确(尤其是当液体样本是唾液时,一般情况下,人或者动物在短时间内所能释放出的唾液的量是非常有限的,很容易导致液体样本量不足)。此外,当收集瓶中有缓冲液时,收集元件还会吸收和带走部分缓冲液或者液体样本与缓冲液的混合液,从而影响到检测结果的准确性。In the existing operation, the collection bottle is used to collect the liquid sample on the collection element, that is, the collection element end of the sampling rod is inserted into the collection bottle, and the collection element is pressed against the side wall or bottom of the collection bottle to make the liquid sample flow out into a collection bottle for sample collection. The problem with existing collection bottles and sampling sticks is that the liquid sample on the collection element of the sampling stick cannot be fully squeezed out, that is, after extrusion, there are still more liquid samples remaining on the collection element, so only There are fewer liquid samples for subsequent detection, so it is easy to cause insufficient liquid sample volume for detection, resulting in test failure or inaccurate test results (especially when the liquid sample is saliva, generally, people or The amount of saliva an animal can release in a short period of time is very limited, which can easily lead to insufficient fluid sample volume). In addition, when there is a buffer in the collection bottle, the collection element will also absorb and take away part of the buffer or the mixture of the liquid sample and the buffer, thereby affecting the accuracy of the detection result.
发明内容Contents of the invention
本发明的目的之一是:针对现有技术的不足,提供一种液体样本收集瓶,用于收集人或者 动物的液体样本。One of the objectives of the present invention is to provide a liquid sample collection bottle for collecting liquid samples of people or animals in view of the deficiencies in the prior art.
本发明的上述目的是通过以下技术方案来实现的:Above-mentioned purpose of the present invention is achieved through the following technical solutions:
一种液体样本收集瓶,包括瓶体,瓶体包括内壁与外壁,内壁包括圆柱体部,其中:瓶体内壁的圆柱体部设有自上而下倾斜和螺旋下降的导轨。A liquid sample collection bottle includes a bottle body, the bottle body includes an inner wall and an outer wall, and the inner wall includes a cylindrical part, wherein: the cylindrical part of the inner wall of the bottle is provided with guide rails that incline and spirally descend from top to bottom.
作为本发明的进一步改进,所述导轨的横截面为矩形、三角形、梯形或者圆弧形,并且导轨横截面尺寸较大的部分位于瓶体的内壁上。As a further improvement of the present invention, the cross-section of the guide rail is rectangular, triangular, trapezoidal or arc-shaped, and the part with a larger cross-sectional size of the guide rail is located on the inner wall of the bottle body.
作为本发明的进一步改进,所述瓶体的内壁展开后,所述导轨为自上而下倾斜的直线。As a further improvement of the present invention, after the inner wall of the bottle body is unfolded, the guide rail is a straight line inclined from top to bottom.
作为本发明的进一步改进,所述瓶体的内壁展开后,所述导轨为自上而下倾斜的平滑曲线。As a further improvement of the present invention, after the inner wall of the bottle body is unfolded, the guide rail is a smooth curve inclined from top to bottom.
作为本发明的进一步改进,所述平滑曲线的斜率自上而下依次降低。As a further improvement of the present invention, the slope of the smooth curve decreases sequentially from top to bottom.
作为本发明的进一步改进,还包括放置在瓶体内的垫板,所述垫板设有便于液体样本通过的通孔。As a further improvement of the present invention, it also includes a backing plate placed in the bottle, and the backing plate is provided with through holes for the passage of liquid samples.
作为本发明的进一步改进,所述垫板之上表面设有凸起或者凹陷。As a further improvement of the present invention, the upper surface of the backing plate is provided with protrusions or depressions.
作为本发明的进一步改进,所述导轨螺旋下降瓶体内壁的六分之一周到一周。As a further improvement of the present invention, the guide rail spirally descends one-sixth to one week of the inner wall of the bottle.
本发明的目的之二是:针对现有技术的不足,提供一种液体样本收集装置,用于收集人或者动物的液体样本。The second object of the present invention is to provide a liquid sample collection device for collecting human or animal liquid samples in view of the deficiencies in the prior art.
本发明的上述目的是通过以下技术方案来实现的:Above-mentioned purpose of the present invention is achieved through the following technical solutions:
一种液体样本收集装置,包括液体样本收集瓶和取样器,其中液体样本收集瓶包括瓶体,瓶体包括内壁与外壁,内壁包括圆柱体部,取样器包括杆部和汲液部,所述汲液部连接至杆部的下端,其中:瓶体内壁的圆柱体部设有自上而下倾斜和螺旋下降的导轨,杆部的下端设有导槽,取样器的杆部下端插入液体样本收集瓶内后,杆部下端的导槽与瓶体内壁之导轨相互配合,引导取样器的杆部下端在液体样本收集瓶内螺旋下降。A liquid sample collection device, comprising a liquid sample collection bottle and a sampler, wherein the liquid sample collection bottle includes a bottle body, the bottle body includes an inner wall and an outer wall, the inner wall includes a cylindrical part, the sampler includes a rod part and a liquid extraction part, the The liquid-absorbing part is connected to the lower end of the rod part, wherein: the cylindrical part of the inner wall of the bottle is provided with a guide rail inclined from top to bottom and spirally descending, and the lower end of the rod part is provided with a guide groove, and the lower end of the rod part of the sampler is inserted into the liquid sample After collecting in the bottle, the guide groove at the lower end of the rod cooperates with the guide rail on the inner wall of the bottle to guide the lower end of the rod of the sampler to descend spirally in the liquid sample collection bottle.
作为本发明的进一步改进,所述瓶体内壁之导轨的横截面为矩形、三角形、梯形或者圆弧形,并且导轨横截面尺寸较大的部分位于瓶体的内壁上。As a further improvement of the present invention, the cross-section of the guide rail on the inner wall of the bottle is rectangular, triangular, trapezoidal or arc-shaped, and the larger part of the guide rail cross-section is located on the inner wall of the bottle body.
作为本发明的进一步改进,所述液体样本收集瓶之瓶体的内壁展开后,所述导轨为自上而下倾斜的直线。As a further improvement of the present invention, after the inner wall of the bottle body of the liquid sample collection bottle is unfolded, the guide rail is a straight line inclined from top to bottom.
作为本发明的进一步改进,所述液体样本收集瓶之瓶体的内壁展开后,所述导轨为自上而下倾斜的平滑曲线。As a further improvement of the present invention, after the inner wall of the bottle body of the liquid sample collection bottle is expanded, the guide rail is a smooth curve inclined from top to bottom.
作为本发明的进一步改进,所述平滑曲线的斜率自上而下依次降低。As a further improvement of the present invention, the slope of the smooth curve decreases sequentially from top to bottom.
作为本发明的进一步改进,还包括放置在液体样本收集瓶内的垫板,所述垫板设有便于液体样本通过的通孔,在取样器的杆部下端在液体样本收集瓶内螺旋下降的过程中,垫板拧挤或 者挤压取样器的汲液部。As a further improvement of the present invention, it also includes a backing plate placed in the liquid sample collection bottle, the backing plate is provided with a through hole to facilitate the passage of the liquid sample, and the lower end of the rod portion of the sampler spirally descends in the liquid sample collection bottle During the process, the backing plate wrings or squeezes the suction part of the sampler.
作为本发明的进一步改进,所述垫板和取样器的汲液部设有相互配合的凸起和凹陷。As a further improvement of the present invention, the backing plate and the dipping part of the sampler are provided with protrusions and depressions that cooperate with each other.
作为本发明的进一步改进,对汲液部的底部进行硬化处理,使其相对于汲液部的其他部分来说具有更高的硬度,从而更加有利于减少汲液部的底部与垫板上表面之间的滑移。As a further improvement of the present invention, the bottom of the dipping part is hardened so that it has a higher hardness compared to other parts of the dipping part, which is more conducive to reducing the bottom of the dipping part and the upper surface of the backing plate. slippage between.
作为本发明的进一步改进,所述导轨螺旋下降液体样本收集瓶之瓶体内壁的六分之一周到一周。As a further improvement of the present invention, the guide rail spirally descends one-sixth to one week of the inner wall of the liquid sample collection bottle.
作为本发明的进一步改进,所述相互配合的导轨与导槽为一对,或者为均匀分布的两对、三对、四对、五对或者六对。As a further improvement of the present invention, the cooperating guide rails and guide grooves are a pair, or two, three, four, five or six pairs evenly distributed.
作为本发明的进一步改进,所述导轨的底部与垫板之上表面之间的距离大于等于2.5毫米并且小于等于35.0毫米,取样器的杆部下端可以被卡扣在导轨的底部。As a further improvement of the present invention, the distance between the bottom of the guide rail and the upper surface of the backing plate is greater than or equal to 2.5 mm and less than or equal to 35.0 mm, and the lower end of the rod portion of the sampler can be snapped on the bottom of the guide rail.
作为本发明的进一步改进,所述导轨之底部的下表面与取样器之杆部下端的上表面各包括一个相互平行的斜面,在顺向旋转取样器的过程中,该一对斜面进一步引导导轨之底部向下挤压取样器的杆部下端。As a further improvement of the present invention, the lower surface of the bottom of the guide rail and the upper surface of the lower end of the rod of the sampler each include a slope parallel to each other. During the process of rotating the sampler in the forward direction, the pair of slopes further guides the The bottom presses down on the lower end of the stem of the sampler.
本发明的目的之三是:针对现有技术的不足,提供一种收集液体样本的方法,用于收集人或者动物的液体样本。The third object of the present invention is to provide a method for collecting liquid samples for collecting human or animal liquid samples in view of the deficiencies in the prior art.
本发明的上述目的是通过以下技术方案来实现的:Above-mentioned purpose of the present invention is achieved through the following technical solutions:
一种收集液体样本的方法,提供一种液体样本收集装置,该液体样本收集装置包括取样器和液体样本收集部件,取样器和液体样本收集部件之间设有倾斜和螺旋下降的导引机构用于引导取样器在液体样本收集部件内螺旋下降,该方法包括如下步骤:A method for collecting a liquid sample. A liquid sample collecting device is provided. The liquid sample collecting device includes a sampler and a liquid sample collecting part. An inclined and spirally descending guide mechanism is provided between the sampler and the liquid sample collecting part. In order to guide the sampler to descend spirally in the liquid sample collecting part, the method includes the following steps:
A、使取样器的汲液部汲取预定数量的液体样本;A. Make the liquid sampling part of the sampler draw a predetermined amount of liquid samples;
B、将取样器的汲液部插入液体样本收集部件内,使取样器的倾斜导槽与液体样本收集部件之内壁上的倾斜和螺旋下降的导轨相对应;B. Insert the suction part of the sampler into the liquid sample collection part, so that the inclined guide groove of the sampler corresponds to the inclined and spiral descending guide rail on the inner wall of the liquid sample collection part;
C、推动取样器下行,在导槽与导轨相互配合的引导下,使取样器在液体样本收集部件内螺旋下降,从而拧挤或者挤压取样器之汲液部,直至汲液部被充分拧挤或者挤压;C. Push the sampler down, and under the guidance of the mutual cooperation between the guide groove and the guide rail, the sampler is spirally descended in the liquid sample collection part, so as to wring or squeeze the liquid-absorbing part of the sampler until the liquid-absorbing part is fully twisted squeeze or squeeze
D、使取样器逆向盘旋上升,取出取样器,密封液体样本收集部件。D. The sampler is reversely spiraled up, the sampler is taken out, and the liquid sample collection part is sealed.
作为本发明的进一步改进,所述液体样本收集装置如本发明二所披露。As a further improvement of the present invention, the liquid sample collection device is as disclosed in the second invention.
作为本发明的进一步改进,所述液体样本收集部件之内壁上的导轨的底部与垫板之上表面之间的距离大于等于2.5毫米并且小于等于35.0毫米;在上述步骤C和D之间,当取样器的杆部下端的上表面低于导轨的底部后,还包括进一步顺向旋转取样器,直至取样器的杆部下端被卡扣在导轨的底部的步骤。As a further improvement of the present invention, the distance between the bottom of the guide rail on the inner wall of the liquid sample collecting part and the upper surface of the backing plate is greater than or equal to 2.5 mm and less than or equal to 35.0 mm; between the above steps C and D, when After the upper surface of the lower end of the rod portion of the sampler is lower than the bottom of the guide rail, the step of further rotating the sampler forwardly until the lower end of the rod portion of the sampler is buckled on the bottom of the guide rail is also included.
本发明的目的之四是:针对现有技术的不足,提供一种检测装置,用于收集人或者动物的液体样本。The fourth object of the present invention is to provide a detection device for collecting liquid samples of humans or animals in view of the deficiencies of the prior art.
本发明的上述目的是通过以下技术方案来实现的:Above-mentioned purpose of the present invention is achieved through the following technical solutions:
一种检测装置,包括液体样本收集装置和检测板,液体样本收集装置包括液体样本收集部件和取样器,其中液体样本收集部件包括圆柱体形的内壁,取样器包括杆部和汲液部,所述汲液部连接至杆部的下端,其中:圆柱体形的内壁设有自上而下倾斜和螺旋下降的导轨,杆部的下端设有导槽,取样器的杆部下端插入液体样本收集部件内后,杆部下端的导槽与圆柱体形的内壁之导轨相互配合,引导取样器的杆部下端在液体样本收集部件内螺旋下降,进而拧挤或者挤压取样器的汲液部,检测板包括检测部件,检测部件用于给出检测结果信息。A detection device, comprising a liquid sample collection device and a detection plate, the liquid sample collection device includes a liquid sample collection part and a sampler, wherein the liquid sample collection part includes a cylindrical inner wall, the sampler includes a rod part and a liquid suction part, the The liquid-absorbing part is connected to the lower end of the rod part, wherein: the inner wall of the cylinder is provided with a guide rail inclined and spirally descending from top to bottom, and the lower end of the rod part is provided with a guide groove, and the lower end of the rod part of the sampler is inserted into the liquid sample collecting part Finally, the guide groove at the lower end of the rod cooperates with the guide rail on the cylindrical inner wall to guide the lower end of the rod of the sampler to spirally descend in the liquid sample collection part, and then twist or squeeze the liquid-absorbing part of the sampler. The detection board includes a detection plate. Component, the detection component is used to give the detection result information.
作为本发明的进一步改进,所述液体样本收集部件与检测板或者检测板的部件是相互分离的独立元件。As a further improvement of the present invention, the liquid sample collecting part and the detection plate or parts of the detection plate are independent components separated from each other.
作为本发明的进一步改进,所述液体样本收集部件安装于检测板或者检测板的部件上。As a further improvement of the present invention, the liquid sample collection component is mounted on the detection board or a component of the detection board.
本发明在液体样本收集瓶的内壁设置自上而下倾斜和螺旋下降的导轨,在取样之杆部下端设置导槽,取样器的汲液部在汲取了足够的液体样本后,插入取样瓶内,在导轨和导槽的相互配合下,引导取样器之杆部下端带动汲液部在取样瓶内作螺旋下降运动,进而对汲液部产生类似于拧湿毛巾的挤压效果,从而充分地将汲液部所汲取的液体样本挤脱出。与现有技术相比,本发明具有液体样本挤脱率更高,在汲液部汲取相同液体样本的情况下,能够挤脱出更多的液体样本用于检测,从而更容易满足检测所需的液体样本的最低量,进而提高了检测的成功率和检测结果的准确性。In the present invention, a guide rail inclined from top to bottom and spirally descending is arranged on the inner wall of the liquid sample collection bottle, and a guide groove is arranged at the lower end of the rod part of the sample. , under the mutual cooperation of the guide rail and the guide groove, the lower end of the rod part of the guide sampler drives the liquid extraction part to perform a spiral downward movement in the sampling bottle, and then produces a squeezing effect similar to wringing a wet towel on the liquid absorption part, thereby fully Squeeze out the liquid sample drawn by the liquid absorbing part. Compared with the prior art, the present invention has a higher liquid sample extrusion rate, and can squeeze out more liquid samples for detection when the same liquid sample is drawn by the suction part, so that it is easier to meet the detection requirements. The minimum amount of liquid samples, thereby improving the success rate of detection and the accuracy of detection results.
图1为本发明的液体样本收集瓶的平面示意图。Fig. 1 is a schematic plan view of a liquid sample collection bottle of the present invention.
图2为图1沿A-A线方向的剖面示意图。FIG. 2 is a schematic cross-sectional view along line A-A of FIG. 1 .
图3为本发明的液体样本收集瓶内的垫板平面示意图。Fig. 3 is a schematic plan view of the backing plate in the liquid sample collection bottle of the present invention.
图4为图1的俯视图。FIG. 4 is a top view of FIG. 1 .
图5为本发明的液体样本收集装置的平面示意图(取样器未插入到液体样本收集瓶内)。Fig. 5 is a schematic plan view of the liquid sample collection device of the present invention (the sampler is not inserted into the liquid sample collection bottle).
图6为图5沿A-A线方向的局部剖面示意图。FIG. 6 is a schematic partial cross-sectional view along the line A-A of FIG. 5 .
图7与图5相似,但取样器插入到液体样本收集瓶内的初始位置(汲水部尚未被挤压)。Figure 7 is similar to Figure 5, but with the sampler inserted into the liquid sample collection bottle in its initial position (the dip has not been squeezed).
图8为图7沿A-A线方向的剖面示意图。FIG. 8 is a schematic cross-sectional view along line A-A of FIG. 7 .
图9为图8中“A”部的局部放大图。FIG. 9 is a partially enlarged view of part "A" in FIG. 8 .
图10-12为图9的变更设计示意图。10-12 are schematic diagrams of modified designs of FIG. 9 .
图13为本发明的液体样本收集瓶内壁之圆柱体部的局部展开平面示意图。Fig. 13 is a partially developed plan view of the cylindrical part of the inner wall of the liquid sample collection bottle of the present invention.
图14是图13的变更设计示意图。FIG. 14 is a schematic diagram of a modified design of FIG. 13 .
图15与图7相似,但取样器已插入到液体样本收集瓶内的最终位置(汲液部已被充分挤压)。Figure 15 is similar to Figure 7, but with the sampler inserted into the final position in the liquid sample collection bottle (with the dip fully squeezed).
图16为图15沿A-A线方向的剖面示意图。Fig. 16 is a schematic cross-sectional view along the line A-A of Fig. 15 .
图17为图16的变更设计示意图。FIG. 17 is a schematic diagram of a modified design of FIG. 16 .
图18为图17中的局部“B”的放大示意图。FIG. 18 is an enlarged schematic view of part “B” in FIG. 17 .
图19为液体样本收集瓶上的导轨与取样器下部配合的另一视局部角剖视图。Fig. 19 is another partial angular sectional view of the cooperation between the guide rail on the liquid sample collection bottle and the lower part of the sampler.
图20与图19相似,但取样器在图19的基础上继续扭转一定的角度。Figure 20 is similar to Figure 19, but the sampler continues to twist a certain angle on the basis of Figure 19.
图21与图8相似,显示了本发明的另一个变更设计。Fig. 21 is similar to Fig. 8, showing another modified design of the present invention.
图22为图21中局部“C”的放大示意图。FIG. 22 is an enlarged schematic view of part “C” in FIG. 21 .
图23为图22的变更设计图。FIG. 23 is a modified design diagram of FIG. 22 .
图24-29为本发明的液体样本收集装置的导轨与导槽配合的六种具体实施例。24-29 are six specific embodiments of the cooperation between the guide rail and the guide groove of the liquid sample collection device of the present invention.
图30为本发明检测装置的使用状态示意图。Fig. 30 is a schematic diagram of the use state of the detection device of the present invention.
图31为图30所示的检测板的检测结果示意图。FIG. 31 is a schematic diagram of the detection results of the detection board shown in FIG. 30 .
图32为本发明检测装置另一实施例的使用状态示意图。Fig. 32 is a schematic diagram of the use state of another embodiment of the detection device of the present invention.
图33为图32所示的检测板的检测结果示意图。FIG. 33 is a schematic diagram of the detection results of the detection board shown in FIG. 32 .
参照附图和具体实施例对本发明作进一步详细地描述。The present invention is described in further detail with reference to the accompanying drawings and specific embodiments.
上述具体实施方式用来解释说明本发明,仅为本发明的优选实施例,而不是对本发明进行限制,在本发明的精神和权利要求的保护范围内,对本发明作出的任何修改、等同替换、改进等,都落入本发明的保护范围。The above specific embodiments are used to explain the present invention, and are only preferred embodiments of the present invention, rather than limiting the present invention. Within the spirit of the present invention and the protection scope of the claims, any modification, equivalent replacement, Improvements and the like all fall within the protection scope of the present invention.
术语解释Terminology Explanation
本发明之专利说明书(包括权利要求书和摘要)对其所使用的术语进行了解释的,则以本专利说明书的解释为准,没有解释的,则为本技术领域之一般含义。If the patent specification (including claims and abstract) of the present invention explains the terms used, the interpretation of this patent specification shall prevail, and if there is no explanation, it shall be the general meaning in the technical field.
圆柱体:本发明之圆柱体是指其横截面为圆形或者近似圆形,各个横截面的面积相等或者大致相等的中空的柱状体或者中空的桶状体;本发明之圆柱体也包括削去尖部的中空的圆锥体,即,穿过其轴线的纵截面是等腰梯形或者近似等腰梯形,但是梯形之斜边与其高之间的夹角以不超过十五度为佳,但也不限于十五度。总之,只要本领域的技术人员认为能够实现本发明之目的,解决本发明所要解决的技术问题,达成本发明之有益效果的中空的柱状体或者中空 的锥状体均包括在本发明之圆柱体的范围内。Cylinder: The cylinder of the present invention refers to a hollow cylinder or hollow barrel whose cross-section is circular or approximately circular, and the areas of each cross-section are equal or approximately equal; the cylinder of the present invention also includes cut Hollow cone with truncated apex, that is, the longitudinal section through its axis is an isosceles trapezoid or approximately isosceles trapezoid, but the angle between the hypotenuse and the height of the trapezoid is preferably not more than fifteen degrees, but Nor is it limited to fifteen degrees. In a word, as long as those skilled in the art think that the purpose of the present invention can be achieved and the technical problems to be solved by the present invention are solved, the hollow column or hollow cone that achieves the beneficial effects of the present invention are all included in the cylinder of the present invention. In the range.
圆柱体部:形状或结构是本发明之圆柱体的那一部分。Cylindrical part: The part whose shape or structure is a cylinder of the present invention.
液体样本收集瓶:又称为液体样本收集部件,指用于收集液体样本的瓶状物体、杯状物体、筒状物体,以及具有圆柱体内壁的任何外形的物体或者物体的一部分。Liquid sample collection bottle: also known as a liquid sample collection part, refers to a bottle-shaped object, a cup-shaped object, a cylindrical object, and any shape or part of an object with a cylindrical inner wall for collecting liquid samples.
螺旋下降:也称为盘旋下降,即在圆柱体部的内壁,由高处向低处以螺旋的形式逐步下降,形成立体平滑曲线的轨迹。螺旋可以是从若干分之一周到一周或者若干周。Spiral descent: also known as spiral descent, that is, on the inner wall of the cylinder, it gradually descends in the form of a spiral from a high place to a low place, forming a three-dimensional smooth curve trajectory. The spiral can be from a fraction of a turn to a turn or several turns.
矩形、三角形、梯形:既包括数学概念上的矩形、三角形、梯形,也包括近似的矩形、三角形、梯形。Rectangle, triangle, trapezoid: including not only the rectangle, triangle, and trapezoid in mathematical concepts, but also the approximate rectangle, triangle, and trapezoid.
顺向:是指与逆向互为相反的方向,但是顺向并非特指顺时针方向,而是指顺时针或者逆时针方向中的一个。当顺向指的是顺时针方向时,则逆向指的是逆时针方向;反之,当顺向指的是逆时针方向时,则逆向指的是顺时针方向。Forward: refers to the direction opposite to the reverse, but forward does not specifically refer to the clockwise direction, but refers to one of the clockwise or counterclockwise directions. When the forward direction refers to the clockwise direction, the reverse direction refers to the counterclockwise direction; otherwise, when the forward direction refers to the counterclockwise direction, the reverse direction refers to the clockwise direction.
拧挤:一边挤压一边扭转,即物体的两端在彼此相互靠近的同时还朝彼此相反的方向产生旋转运动,产生类似于拧湿毛巾的效果。Squeeze: Squeeze while twisting, that is, the two ends of the object rotate in opposite directions when they are close to each other, producing an effect similar to wringing a wet towel.
汲液部被充分拧挤:是指在正常的人力作用下,对汲液部进行拧挤,以达到将汲液部内的液体基本排脱的效果(液体排脱率明显高于现有技术)。The liquid-absorbing part is fully squeezed: it means that under normal manpower, the liquid-absorbing part is squeezed to achieve the effect of basically draining the liquid in the liquid-absorbing part (the liquid discharge rate is obviously higher than that of the prior art) .
请参阅图1、图2所示,本发明提供一种液体样本收集瓶10,用于收集人或者动物的唾液、血液、尿液、汗液等液体样本,经过处理以后,采用生物学的检测方法(包括免疫学检测方法和非免疫学检测方法)检测这些液体样本中某种或者某些物质的含量,从而获得受检测人体或者动物的生理参数指标。以新型冠状病毒肺炎的检测为例,目前科学家们已经开发出以人或者动物的唾液(包括处理后)为样本进行检测的产品和检测方法,以判断提供该唾液样本的人体或者动物是否感染新型冠状病毒肺炎。该检测方法的重要环节之一是如何收集受检人体或者动物的唾液。本发明的目的是提供一种新型的收集人体或者动物唾液的液体样本收集瓶、液体样本收集装置、检测装置,以及利用该液体样本收集装置收集液体样本的方法。本发明可用于新型冠状病毒肺炎的检测。Please refer to Fig. 1 and Fig. 2, the present invention provides a liquid sample collection bottle 10, which is used to collect liquid samples such as saliva, blood, urine, sweat, etc. (including immunological detection methods and non-immunological detection methods) to detect the content of a certain substance or substances in these liquid samples, so as to obtain the physiological parameter indicators of the tested human body or animal. Taking the detection of new coronavirus pneumonia as an example, scientists have developed products and detection methods that use human or animal saliva (including processed) as samples to determine whether the human body or animal that provided the saliva sample is infected with the new coronavirus. Coronavirus pneumonia. One of the important links of the detection method is how to collect the saliva of the human body or animal to be tested. The object of the present invention is to provide a novel liquid sample collection bottle for collecting human or animal saliva, a liquid sample collection device, a detection device, and a method for collecting liquid samples using the liquid sample collection device. The invention can be used for the detection of novel coronavirus pneumonia.
发明一:液体样本收集瓶Invention 1: Liquid sample collection bottle
请参阅图1、图2所示,本发明液体样本收集瓶10,包括瓶体12,瓶体12包括内壁14和外壁16,内壁14包括圆柱体部18(即内壁14的至少一部分是圆柱体结构),圆柱体部18设有自上而下倾斜和螺旋下降的导轨20。导轨20由内壁14向圆柱体中心线突出适当的距离,并且以螺旋状盘附在内壁14上。请参阅图9-12所示,导轨20的横截面为矩形(包括正方形)、三角形、梯形或者圆弧形(包括部分圆形或者部分椭圆形),并且导轨20之横截面尺寸较大的部分(如图9-12 中的虚线所示)位于瓶体12的内壁14上(即,在由内壁14向圆柱体中心线的方向,导轨20的横截面尺寸相等或者逐渐变小)。Referring to Fig. 1 and shown in Fig. 2, the liquid sample collection bottle 10 of the present invention comprises a bottle body 12, and the bottle body 12 includes an inner wall 14 and an outer wall 16, and the inner wall 14 includes a cylindrical portion 18 (that is, at least a part of the inner wall 14 is a cylinder) structure), the cylindrical part 18 is provided with a guide rail 20 that inclines and descends spirally from top to bottom. The guide rail 20 protrudes from the inner wall 14 to the centerline of the cylinder for an appropriate distance, and is attached to the inner wall 14 as a helical disc. Please refer to Fig. 9-12, the cross-section of the guide rail 20 is rectangular (including square), triangular, trapezoidal or arc-shaped (including part circular or part oval), and the larger part of the cross-section of the guide rail 20 (As shown by the dotted lines in FIGS. 9-12 ) located on the inner wall 14 of the bottle body 12 (that is, in the direction from the inner wall 14 to the centerline of the cylinder, the cross-sectional dimensions of the guide rails 20 are equal or gradually smaller).
请参阅图13所示,在一个实施例中,瓶体12的内壁14之圆柱体部18展开后,内壁14上的导轨20自上而下呈倾斜的直线状。该倾斜的直线与水平面的夹角“A”大于等于三十度并且小于等于七十五度,优选的夹角“A”为六十度和四十五度。如图14所示,在另一个实施例中,瓶体12的内壁14展开后,内壁14上的导轨20自上而下呈倾斜的平滑曲线状。该平滑曲线的斜率依次降低(即该平滑曲线的切线与水平面的夹角逐渐减小)。该实施例优选地,导轨20顶部的切线与水平面的夹角“C”为七十五度,导轨20底部的切线与水平面的夹角“B”为三十度。Please refer to FIG. 13 , in one embodiment, after the cylindrical portion 18 of the inner wall 14 of the bottle body 12 is unfolded, the guide rail 20 on the inner wall 14 is in an inclined straight line from top to bottom. The included angle "A" between the inclined straight line and the horizontal plane is greater than or equal to 30 degrees and less than or equal to 75 degrees, and the preferred included angle "A" is 60 degrees and 45 degrees. As shown in FIG. 14 , in another embodiment, after the inner wall 14 of the bottle body 12 is unfolded, the guide rail 20 on the inner wall 14 is in the shape of an inclined smooth curve from top to bottom. The slope of the smooth curve decreases successively (that is, the angle between the tangent of the smooth curve and the horizontal plane decreases gradually). In this embodiment, preferably, the included angle "C" between the tangent line at the top of the guide rail 20 and the horizontal plane is 75 degrees, and the included angle "B" between the tangent line at the bottom of the guide rail 20 and the horizontal plane is 30 degrees.
如图2所示,液体样本收集瓶10还包括放置在瓶体12内的垫板22。垫板22设有若干个便于液体样本流过的通孔24。垫板22呈圆盘状,其厚度大约2.0-5.0毫米,通常由硬质塑料制成。在图1和图2所示的实施例中,瓶体12包括上、下两个部分,上部分的尺寸要明显大于下部分的尺寸,在这两个部分的连接处形成肩部26。垫板22被放置在肩部26上,并且由肩部26支撑。在一个实施例中,当肩部26的面积为瓶体下部分内径的横截面面积的二倍及以上时,也可以省略垫板22,即垫板22并非是必须的。图3为垫板22的平面俯视图,图4为垫板22被放置在瓶体12内后的平面俯视图。在一个实施例中,垫板22之上表面设有凹陷30(如图22所示,该凹陷也可以是通孔24,如图3所示)或者凸起28(如图23所示)。导轨20至少倾斜和螺旋下降瓶体内壁18的六分之一周,但优选不超过一周(并非一定不能超过一周,在某些情况下,也可以是若干周)。在圆柱体部的内壁18上可以设置一根导轨20(如图24所示),也可以均匀地设置二根、三根、四根、五根和六根导轨20(如图25-29所示),但是导轨20的数量并不应当限制本发明的保护范围。As shown in FIG. 2 , the liquid sample collection bottle 10 further includes a backing plate 22 placed in the bottle body 12 . The backing plate 22 is provided with several through holes 24 to facilitate the flow of liquid samples. The backing plate 22 is in the shape of a disc with a thickness of about 2.0-5.0 mm and is usually made of hard plastic. In the embodiment shown in FIGS. 1 and 2 , the bottle body 12 includes an upper part and a lower part. The size of the upper part is obviously larger than that of the lower part. A shoulder 26 is formed at the junction of the two parts. The backing plate 22 is placed on and supported by the shoulder 26 . In one embodiment, when the area of the shoulder 26 is twice or more than the cross-sectional area of the inner diameter of the lower part of the bottle body, the backing plate 22 can also be omitted, that is, the backing plate 22 is not necessary. FIG. 3 is a top plan view of the backing plate 22 , and FIG. 4 is a top plan view of the backing plate 22 after being placed in the bottle body 12 . In one embodiment, a depression 30 (as shown in FIG. 22 , the depression may also be a through hole 24 as shown in FIG. 3 ) or a protrusion 28 (as shown in FIG. 23 ) is provided on the upper surface of the backing plate 22 . The guide rail 20 is at least inclined and spirally descends one-sixth of the circle of the inner wall 18 of the bottle, but preferably no more than one circle (not necessarily no more than one circle, in some cases, it can also be several circles). One guide rail 20 (as shown in Figure 24) can be set on the inner wall 18 of the cylinder part, and two, three, four, five and six guide rails 20 can also be evenly arranged (as shown in Figures 25-29) , but the number of guide rails 20 should not limit the protection scope of the present invention.
发明二、液体样本收集装置Invention 2. Liquid sample collection device
请参阅图5-8所示,本发明还提供一种液体样本收集装置100,该液体样本收集装置100包括如发明一所述的液体样本收集瓶10(为避免重复,将发明一中的内容全部并入发明二中,在发明二中不再对液体样本收集瓶10的具体结构进行详细描述)和取样器50。取样器50包括杆部52和连接至杆部下端54的汲液部56。汲液部56由吸水性能和排水性能均优越的材料制造,例如海棉、脱脂棉、纱布、特种纤维等。杆部52由硬质材料制成,杆部下端54呈圆饼状,其外周设有导槽58,该导槽58的形状和尺寸与瓶体内壁14上的导轨20相对应(图5和图6所示的导槽58为倾斜的,并且倾斜的方向与导轨20一致),杆部下端54的大小与瓶体内壁14所围成的空间相适应,从而既使导轨20能在导槽58内自由滑移,又能使导轨20与导槽58相互配合起到引导杆部下端54螺旋下降的作用。当将取样器50的杆部下端54插入液体样本收集瓶10内后,杆部下端54 的导槽58与瓶体内壁14上的导轨20相互配合,导引取样器50的杆部下端54在液体样本收集瓶内螺旋下降。当汲液部56的底部挤压垫部22的上表面时,两者之间的表面摩擦力减少了汲液部56的底部相对垫部22的相对滑动,然而导轨20导引杆部下端54带动汲液部56的上部继续扭转下降,从而杆部下端54一边向下挤压一边扭转汲液部56,产生拧挤汲液部56的效果(类似于拧湿毛巾),进而更加彻底地将液体样本从汲液部56排出到液体样本收集瓶10内,与收集瓶内的裂解液60(如图8所示)混合,形成裂解液与液体样本的混合液62(如图16所示)。5-8, the present invention also provides a liquid sample collection device 100, which includes the liquid sample collection bottle 10 as described in the first invention (in order to avoid repetition, the content in the first invention All are incorporated into the second invention, and the specific structure of the liquid sample collection bottle 10) and the sampler 50 will not be described in detail in the second invention. The sampler 50 includes a stem 52 and a dip 56 connected to a lower end 54 of the stem. The liquid-absorbing part 56 is made of a material with excellent water absorption and drainage properties, such as sponge, absorbent cotton, gauze, special fiber and the like. Rod 52 is made of hard material, and the lower end 54 of the rod is disc-shaped, and its periphery is provided with guide groove 58, and the shape and size of this guide groove 58 are corresponding to guide rail 20 on the bottle inner wall 14 (Fig. 5 and The guide groove 58 shown in Figure 6 is inclined, and the direction of inclination is consistent with the guide rail 20), the size of the bar lower end 54 is adapted to the space surrounded by the bottle inner wall 14, so that even the guide rail 20 can move in the guide groove 58, the guide rail 20 and the guide groove 58 can cooperate with each other to play the role of guiding the lower end 54 of the rod portion to spiral down. After the rod lower end 54 of the sampler 50 is inserted in the liquid sample collection bottle 10, the guide groove 58 of the rod lower end 54 cooperates with the guide rail 20 on the bottle inner wall 14, and the rod lower end 54 of the guide sampler 50 is in the Spiral descending inside liquid sample collection bottle. When the bottom of the dipping portion 56 presses against the upper surface of the pad portion 22, the surface friction between the two reduces the relative sliding of the bottom of the dipping portion 56 relative to the pad portion 22, while the guide rail 20 guides the lower end 54 of the stem portion. Drive the upper part of the liquid-absorbing part 56 to continue to twist and descend, so that the lower end 54 of the rod part twists the liquid-absorbing part 56 while squeezing downward, and produces the effect of squeezing the liquid-absorbing part 56 (similar to wringing a wet towel), and then more thoroughly The liquid sample is discharged from the drawing part 56 into the liquid sample collection bottle 10, and mixed with the lysate 60 in the collection bottle (as shown in FIG. 8 ) to form a mixed solution 62 of the lysate and the liquid sample (as shown in FIG. 16 ). .
如在发明一中所述,瓶体12的内壁14之圆柱体部18展开后,内壁14上的导轨20自上而下呈倾斜的直线状或者平滑曲线状。请参阅图14,平滑曲线状的导轨有利于在开始下降阶段时,导轨20和导槽58引导杆部下端54加快下降的速度,从而对汲液部产生更强烈的向下挤压,而在接近下降结束阶段时,导轨20和导槽58引导杆部下端54产生更强烈的扭转,从而对汲液部56产生更好的拧挤效果,从汲液部56拧挤出更多的液体样本。As described in the first invention, after the cylinder portion 18 of the inner wall 14 of the bottle body 12 is unfolded, the guide rail 20 on the inner wall 14 is in the shape of an inclined straight line or a smooth curve from top to bottom. Please refer to FIG. 14 , the smooth curved guide rail is beneficial to the guide rail 20 and the guide groove 58 to guide the lower end 54 of the rod part to accelerate the descending speed at the beginning of the descending stage, thereby exerting a stronger downward extrusion on the liquid extraction part, while in the When approaching the end of the descent, the guide rail 20 and the guide groove 58 guide the lower end 54 of the rod part to produce a stronger twist, thereby producing a better wringing effect on the liquid drawing part 56, and squeezing out more liquid samples from the liquid drawing part 56 .
如图21-23所示,为了减少汲液部56的底部与垫板22之上表面之间的相对滑动,在垫板22的上表面和取样器之汲液部56的底部设有相互配合的凸起28和凹陷30,该等凸起和凹陷相互配合减少了汲液部56的底部与垫板22之上表面之间的相对滑移,增强了对汲液部56的拧挤效果。既可以在垫板22的上表面设置凹陷30(该凹陷也可以是通孔24)和在取样器之汲液部56的底部设置凸起28(如图22所示),也可以在垫板22的上表面设置凸起28和在取样器之汲液部56的底部设置凹陷30(如图23所示),或者使汲液部56的底部和垫板22的上表面做成粗糙的表面,以增加两者之间的摩擦力。优选地,对汲液部56的底部进行硬化处理,使其相对于汲液部的其他部分来说具有更高的硬度,从而更加有利于减少汲液部56的底部与垫板22上表面之间的滑移,提高了对汲液部56的拧挤效果,进而提高了对汲液部56的液体样本排脱率。As shown in Figures 21-23, in order to reduce the relative sliding between the bottom of the liquid absorbing portion 56 and the upper surface of the backing plate 22, the upper surface of the backing plate 22 and the bottom of the liquid absorbing portion 56 of the sampler are provided with mutual cooperation. The protrusions 28 and the depressions 30 cooperate with each other to reduce the relative slippage between the bottom of the dipping part 56 and the upper surface of the backing plate 22, and enhance the wringing effect on the dipping part 56. Both can be provided with depression 30 (this depression also can be through hole 24) on the upper surface of backing plate 22 and be provided with protrusion 28 (as shown in Figure 22) at the bottom of the dipping part 56 of sampler, also can be on backing plate The upper surface of the sampler 22 is provided with a protrusion 28 and a depression 30 (as shown in Figure 23 ) at the bottom of the dipping portion 56 of the sampler, or the bottom of the dipping portion 56 and the upper surface of the backing plate 22 are made rough. , to increase the friction between the two. Preferably, the bottom of the dipping portion 56 is hardened so that it has a higher hardness compared to other parts of the dipping portion, so that it is more conducive to reducing the gap between the bottom of the dipping portion 56 and the upper surface of the backing plate 22. The sliding between them improves the squeezing effect on the liquid-absorbing part 56, and further improves the discharge rate of the liquid sample from the liquid-absorbing part 56.
如图24所示,相互配合的导轨20与导槽58为一对。如图25-29所示,为提高导引的平稳性,相互配合的导轨20与导槽58也可以是均匀分布的两对、三对、四对、五对或者六对,如此可以提高对汲液部56的拧挤效果,进一步提高从汲液部56拧挤出液体样本的效率。As shown in FIG. 24 , the guide rail 20 and the guide groove 58 that cooperate with each other form a pair. As shown in Figures 25-29, in order to improve the stability of the guide, the guide rails 20 and the guide grooves 58 that cooperate with each other can also be two pairs, three pairs, four pairs, five pairs or six pairs that are evenly distributed, so that the pairing can be improved. The wringing effect of the liquid drawing part 56 further improves the efficiency of wringing out the liquid sample from the liquid drawing part 56 .
如图2、图6所示,导轨20的底部与垫板22之上表面之间的距离“L”大于等于2.5毫米并且小于等于35.0毫米,该距离“L”能使取样器50的杆部下端54卡扣在导轨20的底部(如图17、18所示)。如此设计的优点是:在操作人员放手后仍然能使汲液部56保持在被扭转压缩的状态。As shown in Fig. 2 and Fig. 6, the distance "L" between the bottom of the guide rail 20 and the upper surface of the backing plate 22 is greater than or equal to 2.5 millimeters and less than or equal to 35.0 millimeters, and this distance "L" can make the rod portion of the sampler 50 The lower end 54 is buckled on the bottom of the guide rail 20 (as shown in FIGS. 17 and 18 ). The advantage of such a design is that the liquid-absorbing part 56 can still be kept in a twisted and compressed state after the operator lets go.
如图19、图20所示,导轨20之底部的下表面与取样器50之杆部下端56的部分上表面为一对相互配合的斜面32、34。在顺向(如图19、20是箭头方向所示)旋转取样器的过程中,该一对斜面具有导引作用,并且使导轨20之底部进一步向下挤压取样器50的杆部下端54,在操作人员放手后仍然使取样器之杆部下端受到导轨20之底部的挤压。As shown in FIGS. 19 and 20 , the lower surface of the bottom of the guide rail 20 and the upper surface of part of the lower end 56 of the rod portion of the sampler 50 are a pair of inclined surfaces 32 and 34 that cooperate with each other. In the process of rotating the sampler in the forward direction (as shown by the arrows in Figures 19 and 20), the pair of inclined surfaces have a guiding effect, and make the bottom of the guide rail 20 further press the lower end 54 of the rod portion of the sampler 50 downward. , still make the lower end of the rod portion of the sampler be squeezed by the bottom of the guide rail 20 after the operator lets go.
发明三:一种收集液体样本的方法Invention 3: A method for collecting liquid samples
本发明还提供一种收集液体样本的方法,该方法提供如上述发明一和发明二所揭示的液体样本收集部件10和取样器50,液体样本收集部件10和取样器50之间设有倾斜和螺旋下降的导引机构用于引导取样器50在液体样本收集部件10内螺旋下降。该方法包括如下步骤:The present invention also provides a method for collecting a liquid sample. The method provides the liquid sample collecting part 10 and the sampler 50 as disclosed in the first and second inventions above. The guide mechanism for spiral descent is used to guide the sampler 50 to descend spirally in the liquid sample collection part 10 . The method comprises the steps of:
A、使取样器50的汲液部56汲取预定数量的液体样本;A. Make the liquid sampling part 56 of the sampler 50 draw a predetermined amount of liquid samples;
B、将取样器的杆部下端54插入液体样本收集部件10内,使两者之间形成所述导引机构;B. Insert the lower end 54 of the rod part of the sampler into the liquid sample collecting part 10, so that the guiding mechanism is formed between the two;
C、推动取样器50下行,在导引机构的引导下,使取样器的汲液部56在液体样本收集瓶10内顺向螺旋下降,从而拧挤或者挤压取样器的汲液部56,直至汲液部56被充分拧挤或者挤压;C. Push the sampler 50 down, and under the guidance of the guide mechanism, make the liquid-absorbing part 56 of the sampler spirally descend in the liquid sample collection bottle 10, thereby twisting or squeezing the liquid-absorbing part 56 of the sampler, until the dipping part 56 is fully twisted or squeezed;
D、使取样器50逆向盘旋上升,取出取样器50,密封液体样本收集瓶10。D. The sampler 50 is spiraled upward in reverse, the sampler 50 is taken out, and the liquid sample collection bottle 10 is sealed.
作为进一步改进,导引机构包括分别设置在液体样本收集部件10和取样器50之杆部下端的导轨20和导槽58(或者导槽20和导轨58)。As a further improvement, the guide mechanism includes guide rails 20 and guide grooves 58 (or guide grooves 20 and guide rails 58 ) respectively arranged at the lower ends of the rods of the liquid sample collecting part 10 and the sampler 50 .
作为进一步改进,液体样本收集瓶10之内壁上的导轨20的底部与垫板22之上表面之间的距离大于等于2.5毫米并且小于等于35.0毫米;在上述步骤C和D之间,当取样器的杆部下端54的上表面低于导轨20的底部后,该方法还包括进一步顺向旋转取样器50,直至取样器的杆部下端54被卡扣在导轨20的底部的步骤。如此可使取样器的杆部下端54保持在导轨20的底部,从而更加充分地拧挤或者挤压汲液部56,提高了对液体样本的排脱率。As a further improvement, the distance between the bottom of the guide rail 20 on the inner wall of the liquid sample collection bottle 10 and the upper surface of the backing plate 22 is greater than or equal to 2.5 millimeters and less than or equal to 35.0 millimeters; between the above steps C and D, when the sampler After the upper surface of the lower end 54 of the rod portion is lower than the bottom of the guide rail 20, the method further includes the step of further rotating the sampler 50 clockwise until the lower end 54 of the rod portion of the sampler is buckled on the bottom of the guide rail 20. In this way, the lower end 54 of the rod part of the sampler can be kept at the bottom of the guide rail 20, thereby more fully wringing or squeezing the liquid-absorbing part 56, and improving the discharge rate of the liquid sample.
发明四:一种检测装置Invention 4: A detection device
图30、31显示了本发明一种检测装置的使用状态及检测结果。检测装置200包括液体样本收集装置100(结构如“发明二”所述,差异在于增加了一个帽11)和检测板210。液体样本收集装置100包括液体样本收集部件10和取样器50(图30中省略取样器50),其中液体样本收集部件10包括圆柱体形的内壁14,取样器50包括杆部52和汲液部56,汲液部56连接至杆部下端54。圆柱体形的内壁14设有自上而下倾斜和螺旋下降的导轨20,杆部下端54设有与导轨20同向倾斜的导槽58。取样器的杆部下端54插入液体样本收集部件10内后,杆部下端的导槽58与圆柱体形的内壁之导轨20相互配合,引导取样器的杆部下端54在液体样本收集部件10内螺旋下降,进而拧挤或者挤压取样器的汲液部56。检测板210包括检测部件220,检测部件220用于给出检测结果信息。检测板210设有加样区212和检测结果显示区214,以便于观察检测结果。检测部件220在检测结果显示区214具有T线和C线,在检测前,T线和C线是不可见的。在检测后的一段时间内,一般会出现以下几种情况:A、不显示C线(无论是否显示T线),则表示检测失败;B、 显示C线,但不显示T线,则表示检测结果为阴性;C、既显示C线,又显示T线,则表示检测结果为阳性,并且T线浓,则为强阳性,T线淡,则为弱阳性。在如图30、31所示的实施例中,液体样本收集部件10与检测板210或者检测板210的部件是相互分离的独立元件,液体样本收集部件10和取样器50的结构与“发明二”基本相同。Figures 30 and 31 show the use status and detection results of a detection device of the present invention. The detection device 200 includes a liquid sample collection device 100 (the structure is as described in "Invention 2", the difference is that a cap 11 is added) and a detection plate 210 . The liquid sample collection device 100 comprises a liquid sample collection part 10 and a sampler 50 (the sampler 50 is omitted in FIG. , the dipping portion 56 is connected to the lower end 54 of the rod portion. The cylindrical inner wall 14 is provided with a guide rail 20 inclined from top to bottom and spirally descending, and the lower end 54 of the rod part is provided with a guide groove 58 inclined in the same direction as the guide rail 20 . After the lower end 54 of the rod portion of the sampler is inserted into the liquid sample collecting part 10, the guide groove 58 at the lower end of the rod part cooperates with the guide rail 20 on the inner wall of the cylinder to guide the lower end 54 of the rod part of the sampler to descend spirally in the liquid sample collecting part 10. , and then wring or extrude the dipping portion 56 of the sampler. The detection board 210 includes a detection component 220, and the detection component 220 is used for giving detection result information. The test board 210 is provided with a sample loading area 212 and a test result display area 214 for observing the test results. The detection part 220 has a T line and a C line in the detection result display area 214, and the T line and the C line are invisible before detection. Within a period of time after the detection, the following situations generally occur: A. If the C line is not displayed (whether the T line is displayed or not), it means that the detection has failed; B. If the C line is displayed but the T line is not displayed, it means the detection The result is negative; C, showing both the C line and the T line, it means that the test result is positive, and the T line is thick, it is strong positive, and the T line is weak, it is weak positive. In the embodiment shown in Figures 30 and 31, the liquid sample collection part 10 and the detection plate 210 or parts of the detection plate 210 are independent components separated from each other, and the structures of the liquid sample collection part 10 and the sampler 50 are similar to those of "Invention 2" "basically the same.
图32、33显示了本发明另一种检测装置200的使用状态及检测结果。与图30、31所示实施例的不同点在于,液体样本收集部件10是安装于检测板210或者检测板210的某个部件上的。液体样本收集部件10和检测板210或者检测板210的某个部件既可以是分别制作后再组装在一起,也可以是与检测板210或者检测板210的某个部件一体成型后再组装在一起,形成一个整体。液体样本收集部件10的圆柱体形的内壁14上设有自上而下倾斜和螺旋下降的导轨20。杆部下端54设有与导轨20同向倾斜的导槽58。取样器的杆部下端54插入液体样本收集部件10内后,杆部下端的导槽58与圆柱体形的内壁之导轨20相互配合,引导取样器的杆部下端54在液体样本收集部件10内螺旋下降,进而拧挤或者挤压取样器的汲液部56。基本原理和具体结构如“发明二”所披露。32 and 33 show the usage status and detection results of another detection device 200 of the present invention. The difference from the embodiment shown in FIGS. 30 and 31 is that the liquid sample collecting part 10 is mounted on the detection board 210 or a certain part of the detection board 210 . The liquid sample collection part 10 and the detection board 210 or a certain part of the detection board 210 can be manufactured separately and then assembled together, or can be integrally formed with the detection board 210 or a certain part of the detection board 210 and then assembled together , forming a whole. The cylindrical inner wall 14 of the liquid sample collecting part 10 is provided with a guide rail 20 inclined and spirally descending from top to bottom. The lower end 54 of the rod portion is provided with a guide groove 58 inclined in the same direction as the guide rail 20 . After the lower end 54 of the rod portion of the sampler is inserted into the liquid sample collecting part 10, the guide groove 58 at the lower end of the rod part cooperates with the guide rail 20 on the inner wall of the cylinder to guide the lower end 54 of the rod part of the sampler to descend spirally in the liquid sample collecting part 10. , and then wring or extrude the dipping portion 56 of the sampler. The basic principle and specific structure are as disclosed in "Invention 2".
实验experiment
本发明以海棉棒作为取样器50的例子收集人的唾液,用对比实验的方法,检验本发明的有益效果。The present invention uses a sponge stick as an example of the sampler 50 to collect human saliva, and uses the method of comparative experiment to check the beneficial effects of the present invention.
实验方法:experimental method:
步骤一:采用10根本发明的海棉棒依次标号为1-10,用精确到千分之一克的电子称分别称出汲液前每根海棉棒的重量,记录在下表中的“A”栏(重量单位为克,以下同);Step 1: Use the sponge sticks of the 10 fundamental inventions to be numbered 1-10 in sequence, and use an electronic scale accurate to one-thousandth of a gram to weigh the weight of each sponge stick before drawing liquid, and record it in "A" in the table below " column (the unit of weight is grams, the same below);
步骤二:用上述10根海棉棒分别收集10位志愿者的唾液,待海棉棒的海棉头吸收饱和后,分别称出汲液后每根海棉棒的重量,记录在下表中的“B”栏;Step 2: Use the above 10 sponge sticks to collect the saliva of 10 volunteers. After the sponge head of the sponge stick is absorbed and saturated, weigh the weight of each sponge stick after absorbing the liquid, and record it in the following table. Column "B";
步骤三:将上述10根海棉棒分别插入到现有的液体样本收集瓶内,垂直向下挤压海棉头,充分挤出海棉头上的唾液后,分别称出海棉头的重量,记录在下表中的“C”栏;Step 3: Insert the above 10 sponge sticks into the existing liquid sample collection bottles, squeeze the sponge head vertically, fully squeeze out the saliva on the sponge head, and weigh the sponge head respectively , recorded in column "C" in the table below;
步骤四:将执行步骤三后的10根海棉棒分别插入到本发明的液体样本收集瓶内,用本发明的方法充分挤出海棉头上的唾液后,分别称出海棉头的重量,记录在下表中的“D”栏;Step 4: insert the 10 sponge sticks after performing step 3 into the liquid sample collection bottle of the present invention respectively, after fully extruding the saliva on the sponge head with the method of the present invention, weigh the weight of the sponge head respectively , recorded in column "D" in the table below;
步骤五:利用下表中的公式分别计算出这10根海棉棒的汲液量(E)、采用现有方法的样本挤出量(F)、采用本发明方法的样本挤出量(G)、采用现有方法的样本挤出百分比(H)、采用本发明方法的样本挤出百分比(I)以及本发明相对于现在方法提高百分比(J)。Step 5: use the formula in the following table to calculate respectively the amount of liquid drawn (E) of these 10 sponge sticks, the sample extrusion amount (F) using the existing method, and the sample extrusion amount (G) using the method of the present invention. ), adopt the sample extrusion percentage (H) of existing method, adopt the sample extrusion percentage (I) of the method of the present invention and the present invention improve percentage (J) relative to present method.
步骤六:计算出本发明相对于现在方法提高百分比的平均值。Step 6: Calculate the average value of the percentage improvement of the present invention relative to the current method.
表一、现有取样方法和本发明取样方法的对比实验数据Table one, the comparative experimental data of existing sampling method and sampling method of the present invention
根据表一中的实验数据,本发明取样方法比现在取样方法的取样量平均提高了31.30%。该实验表明本发明的取样装置和取样方法的有益效果十分突出。According to the experimental data in Table 1, the sampling amount of the sampling method of the present invention is improved by 31.30% on average compared with the current sampling method. This experiment shows that the beneficial effects of the sampling device and sampling method of the present invention are very prominent.
在生物样本检验程序中,本发明所述样本收集瓶与采样棒配合,可充分收集采样棒中的样本,且能同步完成样本的裂解等前处理步骤。在过敏原,肿瘤标志物、性腺标志物、甲功标志物、传染病标志物、糖尿病标志物、肝纤堆化标志物等需要用采样棒采集样本的检测项目中,提高采样标本的利用率。In the biological sample testing procedure, the sample collection bottle of the present invention cooperates with the sampling stick to fully collect the samples in the sampling stick, and can simultaneously complete the pretreatment steps such as sample cracking. In allergens, tumor markers, gonad markers, thyroid function markers, infectious disease markers, diabetes markers, liver fibrosis markers and other testing items that require sampling sticks to collect samples, improve the utilization rate of sampling specimens .
Claims (21)
- 一种液体样本收集瓶,包括瓶体,瓶体包括内壁与外壁,内壁包括圆柱体部,其特征在于:瓶体内壁的圆柱体部设有自上而下倾斜和螺旋下降的导轨。A liquid sample collection bottle, including a bottle body, the bottle body includes an inner wall and an outer wall, and the inner wall includes a cylindrical part, and is characterized in that: the cylindrical part of the inner wall of the bottle is provided with guide rails that incline and spiral down from top to bottom.
- 根据权利要求1所述的液体样本收集瓶,其特征在于:所述导轨的横截面为矩形、三角形、梯形或者圆弧形,并且导轨横截面尺寸较大的部分位于瓶体的内壁上。The liquid sample collection bottle according to claim 1, characterized in that: the cross-section of the guide rail is rectangular, triangular, trapezoidal or arc-shaped, and the part with a larger cross-sectional size of the guide rail is located on the inner wall of the bottle body.
- 根据权利要求1所述的液体样本收集瓶,其特征在于:所述瓶体的内壁展开后,所述导轨为自上而下倾斜的直线。The liquid sample collection bottle according to claim 1, wherein after the inner wall of the bottle body is unfolded, the guide rail is a straight line inclined from top to bottom.
- 根据权利要求1所述的液体样本收集瓶,其特征在于:所述瓶体的内壁展开后,所述导轨为自上而下倾斜的平滑曲线。The liquid sample collection bottle according to claim 1, wherein after the inner wall of the bottle body is unfolded, the guide rail is a smooth curve inclined from top to bottom.
- 根据权利要求4所述的液体样本收集瓶,其特征在于:所述平滑曲线的斜率自上而下依次降低。The liquid sample collection bottle according to claim 4, wherein the slope of the smooth curve decreases successively from top to bottom.
- 根据权利要求1-5之任一者所述的液体样本收集瓶,其特征在于:还包括放置在瓶体内的垫板,所述垫板设有便于液体样本通过的通孔。The liquid sample collection bottle according to any one of claims 1-5, characterized in that it further comprises a backing plate placed in the bottle, and the backing plate is provided with a through hole for the passage of the liquid sample.
- 根据权利要求6所述的液体样本收集瓶,其特征在于:所述垫板之上表面设有凸起或者凹陷。The liquid sample collection bottle according to claim 6, characterized in that: the upper surface of the backing plate is provided with protrusions or depressions.
- 根据权利要求1-5之任一者所述的液体样本收集瓶,其特征在于:所述导轨倾斜和螺旋下降瓶体内壁的六分之一周到一周。The liquid sample collection bottle according to any one of claims 1-5, characterized in that: the guide rail is inclined and spirally descends one-sixth to one week of the inner wall of the bottle.
- 一种液体样本收集装置,包括液体样本收集瓶和取样器,其中液体样本收集瓶包括瓶体,瓶体包括内壁与外壁,内壁包括圆柱体部,取样器包括杆部和汲液部,所述汲液部连接至杆部的下端,其特征在于:瓶体内壁的圆柱体部设有自上而下倾斜和螺旋下降的导轨,杆部的下端设有导槽,取样器的杆部下端插入液体样本收集瓶内后,杆部下端的导槽与瓶体内壁之导轨相互配合,引导取样器的杆部下端在液体样本收集瓶内螺旋下降。A liquid sample collection device, comprising a liquid sample collection bottle and a sampler, wherein the liquid sample collection bottle includes a bottle body, the bottle body includes an inner wall and an outer wall, the inner wall includes a cylindrical part, the sampler includes a rod part and a liquid extraction part, the The liquid-absorbing part is connected to the lower end of the rod part, and it is characterized in that: the cylinder part of the inner wall of the bottle is provided with a guide rail inclined from top to bottom and spirally descending, and the lower end of the rod part is provided with a guide groove, and the lower end of the rod part of the sampler is inserted into the After the liquid sample is collected in the bottle, the guide groove at the lower end of the rod cooperates with the guide rail on the inner wall of the bottle to guide the lower end of the rod of the sampler to descend spirally in the liquid sample collection bottle.
- 根据权利要求9所述的液体样本收集装置,其特征在于:所述导轨的横截面为矩形、三角形、梯形或者圆弧形,并且导轨横截面尺寸较大的部分位于瓶体的内壁上。The liquid sample collection device according to claim 9, characterized in that: the cross-section of the guide rail is rectangular, triangular, trapezoidal or arc-shaped, and the part with a larger cross-sectional size of the guide rail is located on the inner wall of the bottle body.
- 根据权利要求9所述的液体样本收集装置,其特征在于:所述液体样本收集瓶之瓶体的内壁展开后,所述导轨为自上而下的倾斜直线。The liquid sample collection device according to claim 9, characterized in that, after the inner wall of the bottle body of the liquid sample collection bottle is unfolded, the guide rail is an inclined straight line from top to bottom.
- 根据权利要求9所述的液体样本收集装置,其特征在于:所述液体样本收集瓶之瓶体的内壁展开后,所述导轨为自上而下倾斜的平滑曲线。The liquid sample collection device according to claim 9, characterized in that: after the inner wall of the bottle body of the liquid sample collection bottle is unfolded, the guide rail is a smooth curve inclined from top to bottom.
- 根据权利要求12所述的液体样本收集装置,其特征在于:所述平滑曲线的斜率自上而下依次降低。The liquid sample collection device according to claim 12, wherein the slope of the smooth curve decreases sequentially from top to bottom.
- 根据权利要求9-13之任一者所述的液体样本收集装置,其特征在于:还包括放置在液体样 本收集瓶内的垫板,所述垫板设有便于液体样本通过的通孔,在取样器的杆部下端在液体样本收集瓶内螺旋下降的过程中,垫板部挤压取样器的汲液部。The liquid sample collection device according to any one of claims 9-13, characterized in that: it also includes a backing plate placed in the liquid sample collection bottle, the backing plate is provided with a through hole for the liquid sample to pass through, and When the lower end of the rod part of the sampler is spirally descending in the liquid sample collection bottle, the pad part squeezes the liquid-absorbing part of the sampler.
- 根据权利要求14所述的液体样本收集装置,其特征在于:所述垫板和取样器的汲液部设有相互配合的凸起和凹陷。The liquid sample collecting device according to claim 14, characterized in that: the backing plate and the suction part of the sampler are provided with protrusions and depressions that cooperate with each other.
- 根据权利要求15所述的液体样本收集装置,其特征在于:对汲液部的底部进行硬化处理,使其相对于汲液部的其他部分来说具有更高的硬度。The liquid sample collection device according to claim 15, wherein the bottom of the liquid-absorbing part is hardened so that it has a higher hardness than other parts of the liquid-absorbing part.
- 根据权利要求16所述的液体样本收集装置,其特征在于:所述导轨的底部与垫板之上表面之间的距离大于等于2.5毫米并且小于等于35.0毫米,取样器的杆部下端可以被卡扣在导轨的底部。The liquid sample collection device according to claim 16, characterized in that: the distance between the bottom of the guide rail and the upper surface of the backing plate is greater than or equal to 2.5 mm and less than or equal to 35.0 mm, and the lower end of the rod part of the sampler can be stuck Snaps to the bottom of the rail.
- 根据权利要求17所述的液体样本收集装置,其特征在于:所述导轨之底部的下表面与取样器之杆部下端的上表面各包括一个相互平行的斜面,在顺向旋转取样器的过程中,该一对斜面进一步引导导轨之底部向下挤压取样器的杆部下端。The liquid sample collection device according to claim 17, wherein the lower surface of the bottom of the guide rail and the upper surface of the lower end of the rod of the sampler each include a slope parallel to each other, during the process of rotating the sampler in the forward direction , the pair of slopes further guides the bottom of the guide rail to press the lower end of the rod portion of the sampler downward.
- 一种检测装置,包括液体样本收集装置和检测板,液体样本收集装置包括液体样本收集部件和取样器,其中液体样本收集部件包括圆柱体形的内壁,取样器包括杆部和汲液部,所述汲液部连接至杆部的下端,其特征在于:圆柱体形的内壁设有自上而下倾斜和螺旋下降的导轨,杆部的下端设有导槽,取样器的杆部下端插入液体样本收集部件内后,杆部下端的导槽与圆柱体形的内壁之导轨相互配合,引导取样器的杆部下端在液体样本收集部件内螺旋下降,检测板包括检测部件,检测部件用于给出检测结果信息。A detection device, comprising a liquid sample collection device and a detection plate, the liquid sample collection device includes a liquid sample collection part and a sampler, wherein the liquid sample collection part includes a cylindrical inner wall, the sampler includes a rod part and a liquid suction part, the The liquid-absorbing part is connected to the lower end of the rod, and it is characterized in that: the inner wall of the cylinder is provided with a guide rail inclined from top to bottom and spirally descending, the lower end of the rod is provided with a guide groove, and the lower end of the rod of the sampler is inserted into the liquid sample to collect Inside the part, the guide groove at the lower end of the rod cooperates with the guide rail on the inner wall of the cylinder to guide the lower end of the rod of the sampler to spiral down in the liquid sample collection part. The detection board includes the detection part, which is used to give the test result information .
- 如权利要求19所述的检测装置,其特征在于:所述液体样本收集部件与检测板或者检测板的部件是相互分离的独立元件。The detection device according to claim 19, characterized in that the liquid sample collecting part and the detection plate or components of the detection plate are independent components separated from each other.
- 如权利要求19所述的检测装置,其特征在于:所述液体样本收集部件安装于检测板或者检测板的部件上。The detection device according to claim 19, characterized in that the liquid sample collecting part is installed on the detection board or a part of the detection board.
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CN114160219A (en) * | 2021-11-19 | 2022-03-11 | 艾康生物技术(杭州)有限公司 | Liquid sample collecting device and detection device |
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