CN217830064U

CN217830064U - Liquid sample collection bottle

Info

Publication number: CN217830064U
Application number: CN202122860185.1U
Authority: CN
Inventors: 王中平
Original assignee: Acon Biotech Hangzhou Co Ltd
Current assignee: Acon Biotech Hangzhou Co Ltd
Priority date: 2021-11-19
Filing date: 2021-11-19
Publication date: 2022-11-18
Anticipated expiration: 2031-11-19

Abstract

The utility model provides a liquid sample receiving flask, including the bottle, the bottle includes inner wall and outer wall, and the inner wall includes cylindrical portion, wherein: the cylindrical part of the inner wall of the bottle body is provided with a guide rail which inclines from top to bottom and spirally descends. Compared with the prior art, the utility model discloses it is higher to have the crowded rate of taking off of liquid sample to satisfy the minimum volume that detects required liquid sample more easily, and then improved the success rate of detection and the accuracy of testing result.

Description

Liquid sample collection bottle

Technical Field

The utility model belongs to the technical field of medical instrument, further belong to medical science inspection field, especially relate to a liquid sample receiving flask.

Background

There are a variety of clinical lateral flow immunoassay devices that can be used to detect the presence of an analyte in a sample, such as hormones, sugars, adulterants, drugs of abuse (including injection or drug abuse), and the like. The detection of a certain component or components in a liquid sample is typically performed after the liquid sample has been collected and added to a lateral flow immunoassay device.

Wherein the liquid sample may be any volume of liquid to be tested, examined or studied. The liquid sample may be derived from any liquid, for example a bodily fluid such as saliva or blood or urine or other liquid to be tested, such as a water sample from a source of contamination, a liquid sample from a beverage, etc.

Liquid samples are typically collected and absorbed using a sampling wand having a collection element formed of an absorbent material such as a pad or sponge attached to one end of a plunger. The collecting element is such that a sufficient volume of sample liquid can be absorbed from the liquid source, the presence of the sample liquid in the collecting element causing the interior of the collecting element to expand. The collection element typically retains the sample until the collection element is manipulated to release the sample. In the detection, the prior art generally adopts a squeezing mode to squeeze the liquid sample out of the collecting element of the sampling rod, and then the liquid sample is added to a detection device (such as a lateral flow immunoassay device) for detection; or in some detection, the squeezed liquid sample is firstly mixed with a buffer solution for pretreatment such as cracking and the like, and then is added to a detection device for detection.

In the prior art, a collection bottle is used to collect a liquid sample on a collection element, that is, the collection element end of a sampling rod is inserted into the collection bottle, and the collection element is pressed against the side wall or bottom of the collection bottle body to cause the liquid sample to flow out of the collection bottle for sample collection. The existing collection bottle and the existing sampling rod have the problems that the liquid sample on the collection element of the sampling rod cannot be sufficiently extruded, namely, more liquid sample still remains on the collection element after extrusion, so that only less liquid sample is used for subsequent detection, and thus the amount of the liquid sample used for detection is easily insufficient, and detection failure or inaccurate detection result is easily caused (especially when the liquid sample is saliva, the amount of saliva released by a human or an animal in a short time is generally very limited, and the amount of the liquid sample is easily insufficient). In addition, when buffer solution is in the collection bottle, the collection element can absorb and take away part of the buffer solution or the mixed solution of the liquid sample and the buffer solution, so that the accuracy of the detection result is affected.

SUMMERY OF THE UTILITY MODEL

One of the purposes of the utility model is that: in response to the deficiencies of the prior art, a liquid sample collection bottle is provided for collecting a liquid sample from a human or animal.

The above object of the present invention is achieved by the following technical solutions:

a liquid sample receiving bottle, includes the bottle, and the bottle includes inner wall and outer wall, and the inner wall includes the cylinder portion, wherein: the cylindrical part of the inner wall of the bottle body is provided with a guide rail which inclines from top to bottom and spirally descends.

As a further improvement of the utility model, the cross section of the guide rail is rectangular, triangular, trapezoidal or arc-shaped, and the part with larger cross section size of the guide rail is positioned on the inner wall of the bottle body.

As a further improvement, after the inner wall of the bottle body is unfolded, the guide rail is a straight line inclined from top to bottom.

As a further improvement, after the inner wall of the bottle body is unfolded, the guide rail is a smooth curve inclined from top to bottom.

As a further improvement of the present invention, the slope of the smooth curve decreases from top to bottom in sequence.

As a further improvement, the utility model also comprises a backing plate arranged in the bottle body, and the backing plate is provided with a through hole for the liquid sample to pass through.

As a further improvement of the utility model, the upper surface of the backing plate is provided with a bulge or a recess.

As a further improvement of the utility model, the guide rail spirally descends one sixth of the inner wall of the bottle body to one week.

The second purpose of the utility model is that: in view of the shortcomings of the prior art, a liquid sample collection device is provided for collecting a liquid sample of a human or an animal.

the utility model provides a liquid sample collection device, includes liquid sample receiving flask and sampler, and wherein liquid sample receiving flask includes the bottle, and the bottle includes inner wall and outer wall, and the inner wall includes cylindrical part, and the sampler includes pole portion and draws liquid portion, draw the lower extreme that liquid portion is connected to pole portion, wherein: the cylindrical part of the inner wall of the bottle body is provided with a guide rail which inclines from top to bottom and spirally descends, the lower end of the rod part is provided with a guide groove, after the lower end of the rod part of the sampler is inserted into the liquid sample collecting bottle, the guide groove at the lower end of the rod part is matched with the guide rail of the inner wall of the bottle body, and the lower end of the rod part of the sampler is guided to spirally descend in the liquid sample collecting bottle.

As a further improvement of the utility model, the cross section of the guide rail of the inner wall of the bottle body is rectangular, triangular, trapezoidal or arc-shaped, and the part with the larger size of the cross section of the guide rail is positioned on the inner wall of the bottle body.

As a further improvement of the utility model, after the inner wall of the bottle body of the liquid sample collecting bottle is unfolded, the guide rail is a straight line inclined from top to bottom.

As a further improvement of the utility model, after the inner wall of the bottle body of the liquid sample collecting bottle is unfolded, the guide rail is a smooth curve inclined from top to bottom.

As a further improvement, the utility model also comprises a base plate arranged in the liquid sample collecting bottle, the base plate is provided with a through hole for the liquid sample to pass through, and then the liquid drawing part of the sampler is wrung in the process that the screw of the lower end of the rod part of the sampler descends in the liquid sample collecting bottle.

As a further improvement of the utility model, the liquid drawing part of the base plate and the sampler is provided with a bulge and a depression which are matched with each other.

As a further improvement of the utility model, the bottom of the liquid drawing part is hardened, so that the hardness of the bottom of the liquid drawing part is higher than that of other parts of the liquid drawing part, thereby being more beneficial to reducing the slippage between the bottom of the liquid drawing part and the upper surface of the base plate.

As a further improvement of the utility model, the guide rail spirally descends to one sixth of the circumference of the inner wall of the bottle body of the liquid sample collecting bottle.

As a further improvement of the present invention, the mutually matched guide rails and the guide grooves are a pair, or two pairs, three pairs, four pairs, five pairs or six pairs which are uniformly distributed.

As a further improvement of the present invention, the distance between the bottom of the guide rail and the upper surface of the base plate is greater than or equal to 2.5 mm and less than or equal to 35.0 mm, and the lower end of the rod part of the sampler can be buckled at the bottom of the guide rail.

As a further improvement of the utility model, the lower surface of the bottom of guide rail and the upper surface of the pole portion lower extreme of sampler respectively include an inclined plane that is parallel to each other, and at the in-process of consequent rotation sampler, this a pair of inclined plane further guides the bottom of guide rail to extrude the pole portion lower extreme of sampler downwards.

The third purpose of the utility model is: in view of the deficiencies of the prior art, a method of collecting a liquid sample is provided for collecting a liquid sample of a human or animal.

a method of collecting a liquid sample, the method comprising the steps of providing a liquid sample collection device comprising a probe and a liquid sample collection member, and providing an inclined and spiral descending guide mechanism between the probe and the liquid sample collection member for guiding the probe to spiral descend within the liquid sample collection member, the method comprising:

A. making the liquid drawing part of the sampler draw a predetermined amount of liquid samples;

B. inserting the liquid drawing part of the sampler into the liquid sample collecting component, and enabling the inclined guide groove of the sampler to correspond to the inclined and spirally-descending guide rail on the inner wall of the liquid sample collecting component;

C. pushing the sampler to move downwards, and leading the sampler to spirally move downwards in the liquid sample collecting part under the guiding of the mutual matching of the guide groove and the guide rail, so as to screw and squeeze the liquid sucking part of the sampler until the liquid sucking part is fully screwed and squeezed;

D. the sampler is reversely coiled and raised, and the sampler is taken out and the liquid sample collecting part is sealed.

As a further improvement of the present invention, the liquid sample collecting device is disclosed in the second embodiment.

As a further improvement of the present invention, the distance between the bottom of the guide rail on the inner wall of the liquid sample collection member and the upper surface of the pad plate is greater than or equal to 2.5 mm and less than or equal to 35.0 mm; and D, after the upper surface of the lower end of the rod part of the sampler is lower than the bottom of the guide rail, further rotating the sampler in the forward direction until the lower end of the rod part of the sampler is clamped at the bottom of the guide rail.

The fourth purpose of the utility model is that: in response to the deficiencies of the prior art, a testing device is provided for collecting a liquid sample from a human or animal.

a testing device comprising a liquid sample collection device and a testing plate, the liquid sample collection device comprising a liquid sample collection member and a sampler, wherein the liquid sample collection member comprises a cylindrical inner wall, the sampler comprises a stem portion and a liquid drawing portion, the liquid drawing portion being connected to a lower end of the stem portion, wherein: the inner wall of the cylinder is provided with a guide rail which inclines from top to bottom and spirally descends, the lower end of the rod part is provided with a guide groove, after the lower end of the rod part of the sampler is inserted into the liquid sample collecting part, the guide groove at the lower end of the rod part is matched with the guide rail of the inner wall of the cylinder, the lower end of the rod part of the sampler is guided to spirally descend in the liquid sample collecting part, and then the liquid drawing part of the sampler is wrung, and the detection plate comprises a detection part which is used for giving out detection result information.

As a further improvement of the present invention, the liquid sample collection member and the detection plate or a part of the detection plate are separate independent elements.

As a further improvement of the present invention, the liquid sample collecting member is mounted on the detection plate or a part of the detection plate.

Advantageous effects

The utility model discloses set up top-down slope and the guide rail that the spiral descends at the inner wall of liquid sample collecting bottle, set up the guide slot at the pole portion lower extreme of sample, the liquid portion of drawing of sampler is after having drawn sufficient liquid sample, insert in the sample bottle, under the mutually supporting of guide rail and guide slot, the pole portion lower extreme of guide sampler drives the liquid portion of drawing and does the spiral descending motion in the sample bottle, and then produces the crowded effect of twisting to drawing liquid portion to the liquid sample that will draw liquid portion is crowded to be deviate from fully. Compared with the prior art, the utility model discloses it is higher to have the crowded rate of taking off of liquid sample, draws under the condition of the same liquid sample in liquid portion, can crowd and deviate from more liquid samples and be used for detecting to satisfy the minimum that detects required liquid sample more easily, and then improved the success rate of detection and the accuracy of testing result.

Drawings

Fig. 1 is a schematic plan view of a liquid sample collection bottle according to the present invention.

Fig. 2 isbase:Sub>A schematic sectional view taken along linebase:Sub>A-base:Sub>A of fig. 1.

Fig. 3 is a schematic plan view of the pad inside the liquid sample collection bottle of the present invention.

Fig. 4 is a top view of fig. 1.

Fig. 5 is a schematic plan view of the liquid sample collection device of the present invention (the sampler is not inserted into the liquid sample collection bottle).

Fig. 6 isbase:Sub>A partial cross-sectional view taken along linebase:Sub>A-base:Sub>A of fig. 5.

Fig. 7 is a view similar to fig. 5, but with the sampler inserted in the initial position in the liquid sample collection bottle (the scooping portion not yet squeezed).

Fig. 8 isbase:Sub>A cross-sectional view taken along linebase:Sub>A-base:Sub>A of fig. 7.

Fig. 9 is a partially enlarged view of the portion "a" in fig. 8.

Fig. 10-12 are schematic views of the modified design of fig. 9.

Fig. 13 is a partially developed schematic plan view of the cylindrical portion of the inner wall of the liquid sample collection bottle of the present invention.

Fig. 14 is a schematic view of a modified design of fig. 13.

Fig. 15 is similar to fig. 7, but with the sampler inserted in the final position in the liquid sample collection bottle (the dip portion has been squeezed sufficiently).

Fig. 16 isbase:Sub>A schematic sectional view taken along linebase:Sub>A-base:Sub>A of fig. 15.

Fig. 17 is a schematic view of a modified design of fig. 16.

Fig. 18 is an enlarged schematic view of a portion "B" in fig. 17.

Fig. 19 is another partial angular cross-sectional view of the mating of the guide rails on the liquid sample collection bottle with the lower portion of the sampler.

Fig. 20 is similar to fig. 19, but the sampler continues to be twisted at an angle on the basis of fig. 19.

Fig. 21 is similar to fig. 8 and shows another modification of the present invention.

Fig. 22 is an enlarged schematic view of a portion "C" in fig. 21.

Fig. 23 is a modified design diagram of fig. 22.

Fig. 24-29 illustrate six embodiments of the guide rail and guide channel of the fluid specimen collection device of the present invention.

Fig. 30 is a schematic view of the usage state of the detecting device of the present invention.

Fig. 31 is a schematic view showing the detection result of the detection plate shown in fig. 30.

Fig. 32 is a schematic view of a usage status of another embodiment of the detecting device of the present invention.

Fig. 33 is a schematic view showing the detection result of the detection plate shown in fig. 32.

Detailed Description

The invention will be described in further detail with reference to the accompanying drawings and specific embodiments.

The above detailed description is provided to explain the present invention, and is only a preferred embodiment of the present invention, rather than to limit the present invention, and the spirit of the present invention and the scope of the appended claims are intended to cover any modifications, equivalent replacements, improvements, etc. made by the present invention, which fall within the scope of the present invention.

Interpretation of terms

In the present invention, the terms used in the patent specification (including the claims and abstract) are to be interpreted based on the interpretation of the patent specification, and the terms not interpreted are to be interpreted as having a meaning common to the technical field.

Cylinder: the cylinder of the utility model is a cylinder with a circular or approximately circular cross section and the same or approximately equal area of each cross section; the cylinder of the present invention also includes a cone for cutting off the tip portion, i.e., the longitudinal section passing through the axis thereof is isosceles trapezoid or approximately isosceles trapezoid, but the included angle between the inclined side of the trapezoid and the height thereof is better than fifteen degrees. In a word, as long as the technical staff in the field thinks can realize the purpose of the utility model, solve the technical problem that the utility model aims to solve, the columnar body that reaches the beneficial effect of the utility model is all included in the scope of the cylinder of the utility model.

A cylindrical portion: the shape or structure is that part of the cylinder of the present invention.

Liquid sample collection bottle: also known as a liquid sample collection member, refers to a bottle-like object, a cup-like object, a cylindrical object, and any shape object or portion of an object having a cylindrical inner wall for collecting a liquid sample.

Spiral descending: also called spiral descending, namely, the inner wall of the cylindrical part gradually descends in a spiral form from high to low to form a track of a three-dimensional smooth curve. The spiral may be from a fraction of a week to a week or weeks.

Rectangle, triangle, trapezoid: the method not only comprises rectangles, triangles and trapezoids in mathematical concepts, but also comprises approximate rectangles, triangles and trapezoids.

Forward: the direction opposite to the reverse direction is referred to, but the forward direction does not specifically mean the clockwise direction, but means one of the clockwise direction and the counterclockwise direction. When the forward direction refers to the clockwise direction, the reverse direction refers to the counterclockwise direction; conversely, when forward refers to counterclockwise, reverse refers to clockwise.

Twisting and extruding: twisting while squeezing, i.e. the two ends of the object are brought closer together and at the same time are brought into a rotating movement in opposite directions, creating an effect similar to wringing out a towel.

The liquid-sucking part is sufficiently wrung: the method is characterized in that under the action of normal manpower, the liquid drawing part is wrung to achieve the effect of basically discharging liquid in the liquid drawing part (the liquid discharging rate is obviously higher than that in the prior art).

Referring to fig. 1 and 2, the present invention provides a liquid sample collection bottle 10, which is used for collecting liquid samples such as saliva, blood, urine, sweat, etc. of human or animal, and after processing, detecting the content of a certain substance or substances in the liquid samples by using a biological detection method (including an immunological detection method and a non-immunological detection method), so as to obtain physiological parameter indexes of the detected human or animal.

Utility model one: liquid sample collection bottle

Referring to fig. 1 and 2, a liquid sample collecting bottle 10 of the present invention includes a bottle body 12, the bottle body 12 includes an inner wall 14 and an outer wall 16, the inner wall 14 includes a cylindrical portion 18 (i.e., at least a portion of the inner wall 14 is a cylinder structure), and the cylindrical portion 18 is provided with a guide rail 20 that inclines and spirally descends from top to bottom. The guide rail 20 protrudes from the inner wall 14 to the center of the cylinder by a suitable distance and is attached to the inner wall 14 in a spiral-shaped disc. Referring to fig. 9-12, the cross-section of the track 20 is rectangular (including square), triangular, trapezoidal, or circular (including partially circular or partially oval), and the larger cross-sectional dimension of the track 20 (shown by the dotted lines in fig. 9-12) is located on the inner wall 14 of the bottle 12 (i.e., the cross-sectional dimension of the track 20 is equal or gradually smaller from the inner wall 14 to the center of the cylinder).

Referring to FIG. 13, in one embodiment, after the cylindrical portion 18 of the inner wall 14 of the bottle 12 is unfolded, the guide rail 20 of the inner wall 14 is inclined linearly from top to bottom. The included angle "a" between the inclined straight line and the horizontal plane is thirty degrees or more and seventy-five degrees or less, and the preferable included angle "a" is sixty degrees and forty-five degrees. As shown in FIG. 14, in another embodiment, after the interior wall 14 of the bottle body 12 is expanded, the tracks 20 on the interior wall 14 are smoothly curved and inclined from top to bottom. The slope of the smooth curve decreases in sequence (i.e., the included angle between the tangent of the smooth curve and the horizontal plane decreases gradually). Preferably, this embodiment has an angle "C" of seventy-five degrees from the horizontal at the tangent to the top of the rail 20 and thirty degrees from the horizontal at the tangent to the bottom of the rail 20.

As shown in fig. 2, the fluid specimen collection bottle 10 also includes a pad 22 disposed within the body 12. The backing plate 22 is provided with a plurality of through holes 24 for facilitating the flow of the liquid sample therethrough. The backing plate 22 is in the form of a disc having a thickness of about 2.0-5.0 mm and is typically made of a rigid plastic. In the embodiment shown in fig. 1 and 2, the body 12 includes upper and lower portions, the upper portion being of a substantially larger size than the lower portion, a shoulder 26 being formed at the junction of the two portions. The backing plate 22 is placed on the shoulder 26 and is supported by the shoulder 26. In one embodiment, the pad 22 may be omitted when the area of the shoulder 26 is twice or more the cross-sectional area of the inner diameter of the lower portion of the bottle, i.e., the pad 22 is not required. Fig. 3 is a plan view of the mat 22, and fig. 4 is a plan view of the mat 22 after it has been placed within the bottle 12. In one embodiment, the upper surface of the backing plate 22 is provided with a depression (which may also be a through hole 24, as shown in fig. 22) or a protrusion (as shown in fig. 23). The track 20 slopes and spirals down at least one sixth of the circumference of the interior wall 18 of the bottle, but preferably no more than one circumference (not necessarily no more than one circumference, and in some cases, several circumferences). One rail 20 may be disposed on the inner wall 18 of the cylindrical portion (as shown in fig. 24), or two, three, four, five, and six rails 20 may be uniformly disposed (as shown in fig. 25-29), but the number of rails 20 should not limit the scope of the present invention.

Practical liquid sample collecting device

Referring to fig. 5-8, the present invention further provides a liquid sample collecting device 100, wherein the liquid sample collecting device 100 comprises a liquid sample collecting bottle 10 (to avoid repetition, the contents of the first embodiment are all incorporated into the second embodiment) and a sampler 50. Sampler 50 includes a stem portion 52 and a dip portion 56 connected to a lower end 54 of the stem portion. The liquid suction portion 56 is made of a material excellent in both water absorbing performance and water discharging performance, such as sponge, absorbent cotton, gauze, specialty fibers, and the like. The stem 52 is made of a hard material, and the lower end 54 of the stem is shaped like a pie, and the outer periphery of the stem is provided with a channel 58, the channel 58 being shaped and sized to correspond to the track 20 on the inner wall 14 of the bottle body (the channel 58 is slanted as shown in fig. 5 and 6, and the direction of the slant is the same as the track 20), so that the lower end 54 of the stem can be guided to spirally descend by cooperation with the track 20 even though the track 20 can freely slide in the channel 58. When the lower end 54 of the shaft portion of the probe 50 is inserted into the liquid sample collection vial 10, the guide groove 58 of the lower end 54 of the shaft portion cooperates with the guide rail 20 on the inner wall 14 of the vial body to guide the lower end 54 of the shaft portion of the probe 50 to spirally descend within the liquid sample collection vial. When the bottom of the liquid drawing portion 56 presses the upper surface of the pad 22, the surface friction therebetween reduces the relative sliding of the bottom of the liquid drawing portion 56 with respect to the pad 22, however, the lower end 54 of the rod portion is guided by the guide rail 20 to drive the upper portion of the liquid drawing portion 56 to continue twisting and descending, so that the lower end 54 of the rod portion twists and twists the liquid drawing portion 56 while pressing downward, thereby generating the effect of squeezing the liquid drawing portion 56 (similar to squeezing a towel), and further more thoroughly discharging the liquid sample from the liquid drawing portion 56 into the liquid sample collection bottle 10, and mixing with the lysate 60 (shown in fig. 8) in the collection bottle, so as to form a lysate 62 (shown in fig. 16) and the liquid sample.

As described in the first embodiment, after the cylindrical portion 18 of the inner wall 14 of the bottle body 12 is expanded, the guide rail 20 of the inner wall 14 is inclined linearly or smoothly curved from the top to the bottom. The smoothly curved guide rail facilitates the guide rail 20 and the guide groove 58 to guide the rod part lower end 54 to increase the descending speed at the beginning of the descending stage, so as to generate stronger downward extrusion on the liquid drawing part, and the guide rail 20 and the guide groove 58 to guide the rod part lower end 54 to generate stronger torsion near the ending stage of the descending stage, so as to generate better wringing effect on the liquid drawing part 56, so as to wring out more liquid samples from the liquid drawing part 56.

As shown in fig. 21-23, in order to reduce the relative sliding between the bottom of liquid-drawing portion 56 and the upper surface of pad 22, there are protrusions 28 and recesses 30 on the upper surface of pad 22 and the bottom of liquid-drawing portion 56 of the sampler, which cooperate with each other to reduce the relative sliding between the bottom of liquid-drawing portion 56 and the upper surface of pad 22, and to enhance the squeezing effect of liquid-drawing portion 56. The depression 30 (the depression may be the through hole 24) may be provided on the upper surface of the backing plate 22 and the projection 28 may be provided on the bottom of the liquid-drawing portion 56 of the sampler (as shown in fig. 22), or the projection 28 may be provided on the upper surface of the backing plate 22 and the depression 30 may be provided on the bottom of the liquid-drawing portion 56 of the sampler (as shown in fig. 23). Preferably, the bottom of the liquid-drawing portion 56 is hardened to have higher hardness than other portions of the liquid-drawing portion, so as to be more beneficial to reducing the slippage between the bottom of the liquid-drawing portion 56 and the upper surface of the pad 22, improve the squeezing effect of the liquid-drawing portion 56, and further improve the liquid sample discharging rate of the liquid-drawing portion 56.

As shown in fig. 24, the guide rail 20 and the guide groove 58 are paired to be engaged with each other. As shown in fig. 25-29, in order to improve the guiding smoothness, the guide rail 20 and the guide groove 58 may be two, three, four, five or six pairs uniformly distributed, so as to improve the squeezing effect of the liquid-drawing portion 56, and further improve the efficiency of squeezing the liquid sample from the liquid-drawing portion 56.

As shown in fig. 2 and 6, the distance "L" between the bottom of rail 20 and the upper surface of pad 22 is greater than or equal to 2.5 mm and less than or equal to 35.0 mm, which enables the lower end 54 of the shaft of sampler 50 to be snapped into the bottom of rail 20 (as shown in fig. 17 and 18). At this time, the liquid suction portion 56 is in a state of being torsionally compressed.

As shown in fig. 19 and 20, the lower surface of the bottom of rail 20 and the upper surface of the lower end 56 of the shaft of sampler 50 are a pair of

inclined surfaces

32, 34, which have a guiding function during rotation of the sampler in the forward direction (as shown by the arrow in fig. 19 and 20), and cause the bottom of rail 20 to further press down the lower end 54 of the shaft of sampler 50, while still causing the lower end of the shaft of the sampler to be pressed by the bottom of rail 20 after the operator has left his hands free.

Utility model three: method for collecting liquid sample

The present invention also provides a method for collecting a liquid sample, which provides a liquid sample collecting member 10 and a sampler 50, wherein a guiding mechanism for guiding the sampler 50 to spirally descend in the liquid sample collecting member 10 is disposed between the liquid sample collecting member 10 and the sampler 50. The method comprises the following steps:

A. causing liquid-drawing portion 56 of sampler 50 to draw a predetermined number of liquid samples;

B. inserting the lower end 54 of the shaft of the sampler into the liquid sample collection member 10 to form the guide mechanism therebetween;

C. pushing the sampler 50 to move downwards, and leading the liquid drawing part 56 of the sampler to spirally descend in the liquid sample collecting bottle 10 under the guidance of the guide mechanism, so as to screw and squeeze the liquid drawing part 56 of the sampler until the liquid drawing part 56 is fully screwed and squeezed;

D. the sampler 50 is reversely swirled up, the sampler 50 is removed, and the liquid sample collection bottle 10 is sealed.

As a further modification, the guide mechanism includes a guide rail 20 and a guide groove 58 (or a guide groove 20 and a guide rail 58) provided at the lower ends of the shaft portions of the liquid sample collecting member 10 and the sampler 50, respectively.

As a further modification, the distance between the bottom of the guide rail 20 on the inner wall of the liquid sample collection bottle 10 and the upper surface of the pad 22 is 2.5 mm or more and 35.0 mm or less; after the upper surface of the lower rod end 54 of the sampler is lower than the bottom of the rail 20 between steps C and D above, the method further comprises the step of rotating the sampler 50 forward until the lower rod end 54 of the sampler is caught in the bottom of the rail 20. This keeps the lower end 54 of the rod of the sampler at the bottom of the rail 20, thereby squeezing the liquid-drawing portion 56 more sufficiently and improving the removal rate of the liquid sample.

Utility model four: detection device

Fig. 30 and 31 show the usage status and the detection result of the detection device of the present invention. The test device 200 includes a fluid sample collection device 100 (configured as described in utility model II, with the difference that a cap 11 is added) and a test plate 210. The fluid specimen collection device 100 includes a fluid specimen collection member 10 and a sampler 50, wherein the fluid specimen collection member 10 includes a cylindrical inner wall 14, the sampler 50 includes a stem portion 52 and a dip portion 56, and the dip portion 56 is connected to a lower end 54 of the stem portion. The cylindrical inner wall 14 is provided with a guide rail 20 inclined and spirally descending from top to bottom, and the lower end 54 of the rod portion is provided with a guide groove 58 inclined in the same direction as the guide rail 20. After the lower end 54 of the rod portion of the sampler is inserted into the liquid sample collection member 10, the guide groove 58 at the lower end of the rod portion is matched with the guide rail 20 of the cylindrical inner wall, so as to guide the lower end 54 of the rod portion of the sampler to spirally descend in the liquid sample collection member 10, and further to screw and squeeze the liquid drawing portion 56 of the sampler. The detection board 210 comprises a detection part 220, the detection part 220 being arranged to give detection result information. Detection plate 210 is free of sample application area 212 and detection result display area 214 to facilitate viewing of the detection results. The detection section 220 has T and C lines in the detection result display area 214, which are not visible before detection. During a period of time after detection, the following generally occur: A. if the C line is not displayed (no matter whether the T line is displayed or not), the detection is failed; B. c lines are displayed, but T lines are not displayed, and the detection result is negative; C. when both the C line and the T line are displayed, the detection result is positive, the T line is strong positive when the T line is thick, and the T line is weak positive when the T line is light. In the embodiment shown in fig. 30 and 31, the liquid sample collection member 10 and the detection plate 210 or parts of the detection plate 210 are separate independent elements, and the structures of the liquid sample collection member 10 and the sampler 50 are substantially the same as in "utility model two".

Fig. 32 and 33 show the usage status and the detection result of another detection device 200 of the present invention. This embodiment differs from the embodiment shown in fig. 30 and 31 in that the liquid sample collection member 10 is attached to the detection plate 210 or some component of the detection plate 210. The fluid specimen collection member 10 and the detection plate 210 or a member of the detection plate 210 may be separately manufactured and then assembled together, or may be integrally formed with the detection plate 210 or a member of the detection plate 210 and then assembled together to form a single unit. The cylindrical inner wall 14 of the liquid sample collecting member 10 is provided with a guide rail 20 which is inclined from top to bottom and spirally descends. The lower end 54 of the rod portion is provided with a guide groove 58 inclined in the same direction as the guide rail 20. After the lower end 54 of the rod portion of the sampler is inserted into the liquid sample collection member 10, the guide groove 58 at the lower end of the rod portion is matched with the guide rail 20 of the cylindrical inner wall, so as to guide the lower end 54 of the rod portion of the sampler to spirally descend in the liquid sample collection member 10, and further to screw and squeeze the liquid drawing portion 56 of the sampler. The basic principle and the specific structure are disclosed as the second utility model.

Experiment of the invention

The utility model discloses use the sponge stick to collect people's saliva as sampler 50's example, with the method of contrast experiment, inspect the beneficial effect of the utility model.

The experimental method comprises the following steps:

the method comprises the following steps: the sponge sticks of 10 fundamental utility models are sequentially marked as 1-10, the weight of each sponge stick before liquid drawing is respectively weighed by an electronic scale accurate to one thousandth of gram, and the weight is recorded in the column A in the following table (the weight unit is gram, the same below);

step two: collecting saliva of 10 volunteers with the above 10 sponge sticks, weighing the weight of each sponge stick after the sponge head of the sponge stick is saturated, and recording in column B of the following table;

step three: inserting the 10 sponge sticks into the existing liquid sample collecting bottle respectively, vertically pressing the sponge heads downwards, weighing the sponge heads after fully squeezing out saliva on the sponge heads, and recording the weight in column C in the following table;

step four: respectively inserting the 10 sponge sticks after the third step into the liquid sample collecting bottle of the utility model, respectively weighing the weight of the sponge heads after fully extruding saliva on the sponge heads by the method of the utility model, and recording the weight on the column D in the following table;

step five: the liquid drawing amount (E) of the 10 sponge sticks, the sample extrusion amount (F) adopting the prior method, the sample extrusion amount (G) adopting the method, the sample extrusion percentage (H) adopting the prior method, the sample extrusion percentage (I) adopting the method and the percentage (J) improved relative to the prior method are respectively calculated by utilizing the formulas in the following table.

Step six: calculate the average value of the percentage improvement of the utility model compared with the existing method.

Table one, the existing sampling method and the utility model discloses the contrast experiment data of sampling method

According to the experimental data in table one, the utility model discloses the sampling volume that the sampling method is compared present sampling method has improved 31.30% on average. This experiment shows that the utility model discloses a sampling device and sampling method's beneficial effect is very outstanding.

In biological sample inspection procedure, sample collecting bottle and sampling rod cooperation can fully collect the sample in the sampling rod, and can accomplish pretreatment steps such as the schizolysis of sample in step. The utilization rate of the sampling specimen is improved in detection items such as allergens, tumor markers, gonad markers, alpha-functional markers, infectious disease markers, diabetes markers, liver fibrosis markers and the like which need to be sampled by a sampling rod.

Claims

1. The utility model provides a liquid sample receiving flask, includes the bottle, and the bottle includes upper and lower two parts, and the size of upper portion will obviously be greater than the size of lower part, and the upper portion of bottle includes inner wall and outer wall, and the inner wall includes cylinder portion, its characterized in that: the cylindrical part of the inner wall of the bottle body is provided with a guide rail which inclines from top to bottom and spirally descends.

2. The fluid specimen collection bottle of claim 1, wherein: the cross section of the guide rail is rectangular, triangular, trapezoidal or circular arc, and the part of the guide rail with larger cross section size is positioned on the inner wall of the bottle body.

3. The fluid specimen collection bottle of claim 1, wherein: after the inner wall of the bottle body is unfolded, the guide rail is a straight line inclined from top to bottom.

4. The liquid sample collection vial of claim 1, wherein: after the inner wall of the bottle body is unfolded, the guide rail is a smooth curve inclined from top to bottom.

5. The liquid sample collection vial of claim 4, wherein: the slope of the smooth curve decreases from top to bottom in sequence.

6. The fluid specimen collection bottle of any one of claims 1-5, wherein: still including placing the backing plate in the bottle, the backing plate is equipped with the through-hole that is convenient for the liquid sample to pass through.

7. The fluid specimen collection bottle of claim 6, wherein: the upper surface of the backing plate is provided with a bulge or a recess.

8. The fluid specimen collection bottle of any one of claims 1-5, wherein: the guide rail inclines and spirally descends one sixth to one week of the inner wall of the bottle body.