WO2023053337A1 - オンライン調剤システム、情報連携サーバ、オンライン調剤方法、およびプログラム - Google Patents

オンライン調剤システム、情報連携サーバ、オンライン調剤方法、およびプログラム Download PDF

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Publication number
WO2023053337A1
WO2023053337A1 PCT/JP2021/036123 JP2021036123W WO2023053337A1 WO 2023053337 A1 WO2023053337 A1 WO 2023053337A1 JP 2021036123 W JP2021036123 W JP 2021036123W WO 2023053337 A1 WO2023053337 A1 WO 2023053337A1
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WIPO (PCT)
Prior art keywords
information
user
drug
terminal device
pharmacist
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Ceased
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PCT/JP2021/036123
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English (en)
French (fr)
Japanese (ja)
Inventor
武文 茂垣
幸士 是川
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NTT Inc
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Nippon Telegraph and Telephone Corp
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Filing date
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Priority to JP2023550904A priority Critical patent/JP7769244B2/ja
Priority to PCT/JP2021/036123 priority patent/WO2023053337A1/ja
Priority to US18/691,520 priority patent/US20250132061A1/en
Publication of WO2023053337A1 publication Critical patent/WO2023053337A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H70/00—ICT specially adapted for the handling or processing of medical references
    • G16H70/40—ICT specially adapted for the handling or processing of medical references relating to drugs, e.g. their side effects or intended usage
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/13—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered from dispensers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/67—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H80/00—ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring

Definitions

  • the present invention relates to technology for implementing dispensing services online.
  • a user who receives a prescription for medication applies for online medication guidance from a smartphone app, and at the dispensing pharmacy, the pharmacist prepares the medication based on the prescription data issued by the doctor, delivers it to the user, and provides the user with medication guidance. are performed online by pharmacists (see, for example, Non-Patent Document 1).
  • the present invention aims to provide technology capable of improving the quality of online medication guidance.
  • a first information acquiring unit that acquires first information related to side effects of a drug to be delivered to the user based on drug information related to the drug described in the user's prescription and genetic information of the user; , a cooperation processing unit that provides the first information as side effect information related to the drug to a pharmacist terminal device used by a pharmacist; and a pharmacist terminal device that supports implementation of the dosing guidance by communication with a user terminal device used by the user and enables the side effect information to be referred to in the dosing guidance.
  • One aspect of the present invention includes a genetic information server that stores genetic information of a user, a pharmacist terminal device used by a pharmacist who instructs the user on taking medicines to be delivered, and a user terminal device used by the user. and a cooperation processing unit for coordinating various types of information with the user, wherein the cooperation processing unit acquires drug information related to the drug described in the user's prescription from the pharmacist terminal device and provides it to the genetic information server. and providing the pharmacist terminal device with information on side effects of the drug generated by the genetic information server based on the drug information.
  • An aspect of the present invention is a first information acquisition step of acquiring first information related to side effects of a drug to be delivered to the user based on drug information related to the drug described in the user's prescription and genetic information of the user. and an information linking step of providing the first information as side effect information about the drug to a pharmacist terminal device used by a pharmacist, wherein the pharmacist terminal device sends the information to the user when the pharmacist delivers the drug.
  • This is an online drug dispensing method that supports the implementation of the drug administration guidance by communicating with a user terminal device used by the user, and enables the user to refer to the side effect information in the drug administration guidance. .
  • One aspect of the present invention includes a genetic information server that stores genetic information of a user, a pharmacist terminal device used by a pharmacist who instructs the user on taking medicines to be delivered, and a user terminal device used by the user.
  • a computer communicating with the user obtains drug information related to the drug described in the user's prescription from the pharmacist terminal device and provides it to the genetic information server, and the drug generated by the genetic information server based on the drug information is a program for causing the pharmacist terminal device to provide information on the side effects of
  • FIG. 3 is a diagram illustrating an example of the functional configuration of an information linkage server according to the first embodiment;
  • FIG. 4 is a flowchart showing an example of the flow of preprocessing performed by a genetic information server;
  • FIG. 4 is a diagram showing one specific example of a drug metabolism list generated by preprocessing;
  • FIG. 5 is a diagram showing an example of other information related to metabolic rate;
  • 4 is a flowchart showing an example of the flow of this process performed by a genetic information server;
  • 4 is a flow chart showing an example of a flow of processing in which a health checkup information server generates health checkup data;
  • FIG. 4 is a sequence diagram showing an example of the flow of processing executed by each server and each terminal device regarding online medication guidance in the online dispensing system according to the first embodiment; It is a figure which shows the example of a screen of the pharmacist application which operate
  • FIG. 11 is a diagram showing an example of the functional configuration of an information collaboration server according to the second embodiment;
  • FIG. 4 is a flow chart showing an example of the flow of processing performed by a drug combination server;
  • FIG. 10 is a sequence diagram showing an example of the flow of processing executed by each server and each terminal device regarding online medication guidance in the online dispensing system according to the second embodiment;
  • FIG. 1 is a diagram showing a configuration example of an online dispensing system 100A according to the first embodiment of the medication instruction system of the present invention.
  • the online dispensing system 100A is a system that provides online dispensing services to patients (hereinafter referred to as "users") who have been issued prescriptions by doctors.
  • the online dispensing service is a service that provides an online service in which a pharmacist prepares and delivers a drug based on a user's prescription.
  • the online dispensing service includes dosing guidance that is provided when the pharmacist delivers the drug prepared to the user, and the online dispensing service also provides this dosing guidance online.
  • the medication instruction carried out online is referred to as "online medication instruction”.
  • the dosing guidance provided by the pharmacist includes guidance on basic matters such as the timing of taking the drug, the number of doses, and the dosage, as well as guidance on storage methods, side effects to be careful of, and combinations.
  • the online dispensing system 100A includes, for example, a genetic information server 10, a medical examination information server 20, a user terminal device 30, a pharmacist terminal device 40, and an information linkage server 50A.
  • the information collaboration server 50A can communicate with the genetic information server 10, the health checkup information server 20, and the pharmacist terminal device 40.
  • FIG. The user terminal device 30 can communicate with the pharmacist terminal device 40 and the online medical examination system 60 .
  • the online medical examination system 60 is a system that supports online medical examination.
  • the doctor D examines the user U using the online medical examination system 60 and issues a drug prescription in electronic data according to the diagnosis result.
  • the electronic data of the prescription will be referred to as "prescription data".
  • "prescribe” means that the doctor D indicates to the user U the medicine to be delivered by prescription, or instructs the pharmacist M to dispense the medicine to be delivered to the user U by issuing the prescription. It shall be.
  • the genetic information server 10 generates information (hereinafter referred to as “genetic data”) regarding side effects of drugs prescribed for the user U by the doctor D based on the genetic information of the user U, and sends the generated genetic data to the information linkage server 50A.
  • the genetic information is information indicating the constitution of the user U obtained based on the result of the genetic test or the result of the genetic test.
  • the genetic information is obtained by analyzing the blood of the user U collected at a hospital or the like by a genotyping company.
  • genotyping companies mainly detect differences in DNA sequences that differ by one base, called SNPs (single nucleotide polymorphisms), using microarrays and the like.
  • Genotyping may target the entire genome or may target a specific region of the entire genome. Genotyping should be selected according to the required genetic information.
  • the genetic information server 10 preliminarily holds genetic information about the user U of the online dispensing system 100A.
  • the genetic information server 10 is an example of a "first information acquisition unit”. Genetic data is an example of "first information”.
  • the health checkup information server 20 has a function of providing user U's health checkup data to the information linkage server 50A.
  • the health checkup data is data indicating health problems and precautions that can be detected from the health condition of the user U. For example, information indicating the results of the health checkup of the user U (hereinafter referred to as "health checkup information"). generated based on In this embodiment, the health checkup information server 20 preliminarily holds health checkup information indicating the results of the health checkup for the user U of the online dispensing system 100A.
  • the health checkup information server 20 is an example of a "second information acquisition unit”. Health checkup data is an example of "second information”.
  • the user terminal device 30 is a terminal device used by the user U of the online dispensing system 100A to receive online dosing guidance from the pharmacist M.
  • the user terminal device 30 is, for example, a portable terminal device such as a smart phone or a tablet.
  • the user terminal device 30 receives prescription data from the online medical examination system 60 as an input, provides the input prescription data to the pharmacist terminal device 40, and cooperates with the pharmacist terminal device 40 to provide the user U with an online prescription data. It has a function to receive medication guidance.
  • the user terminal device 30 has a function of notifying the information linking server 50A of the medication status of the user U after medicine delivery, and receiving follow-up based on the medication status of the user U from the information linking server 50A.
  • These functions of the user terminal device 30 are realized, for example, by the user terminal device 30 executing an application program (hereinafter referred to as "user application").
  • a follow-up is an example of "supplementary information.”
  • the user application may have a function to support the user U's medical examination by the online medical examination system 60.
  • the user application cooperates with the online medical examination system 60, has a matching function that introduces the user U to the doctor D, a function that provides means of communication with the doctor D (such as a voice call function and a videophone function), and a function that provides medical treatment. It may have a function of linking various types of necessary information (for example, medical questionnaires, health insurance card images, etc.).
  • the user application may be installed in the user terminal device 30 as a dedicated application, or may be realized by a general-purpose application such as a browser.
  • the pharmacist terminal device 40 is a terminal device that is used by the pharmacist M to provide medication guidance and subsequent follow-up online when delivering drugs to the user U.
  • the pharmacist terminal device 40 is, for example, a terminal device such as a PC, a smart phone, or a tablet.
  • the pharmacist terminal device 40 is installed, for example, in a dispensing pharmacy store.
  • the pharmacist terminal device 40 receives prescription data provided from the user terminal device 30 as input, recognizes the drug prescribed by the doctor D to the user U based on the input prescription data, and recognizes the recognized drug. It has a function of providing information (hereinafter referred to as “medicine information”) together with user information about user U to information linkage server 50A. User information includes at least user U identification information. Further, the pharmacist terminal device 40 receives the genetic data provided from the genetic information server 10, the health checkup data of the user U provided from the health checkup information server 20, and the like. It has a function of assisting the pharmacist M in giving the user U instructions on how to take medication based on data and the like. Further, the pharmacist terminal device 40 has a function of instructing the delivery base L to deliver the drug to the user U's residence or the like.
  • the pharmacist terminal device 40 functions of the pharmacist terminal device 40 are realized, for example, by the pharmacist terminal device 40 executing an application program (hereinafter referred to as "pharmacist application").
  • the pharmacist application may be installed in the pharmacist terminal device 40 as a dedicated application, or may be realized by a general-purpose application such as a browser.
  • the information cooperation server 50A has a function of providing the pharmacist terminal device 40 with information necessary for user U's online dosing guidance. Specifically, the information cooperation server 50A accepts user U's user information and drug information as input via the pharmacist terminal device 40, and manages both the inputted user U's user information and drug information in association with each other. Further, in response to a request from the pharmacist terminal device 40, the information cooperation server 50A acquires genetic data related to the drug prescribed to the user U from the genetic information server 10, and also obtains health checkup data of the user U from the health checkup information server 20. , and provides the acquired genetic data and health checkup data of the user U to the pharmacist terminal device 40 .
  • the information linkage server 50A upon receiving a notification of the medication status of user U after delivery of the medicine from the user terminal device 30, the information linkage server 50A records the medication status of the user U, and based on the notified medication status. It has a function of performing a follow-up on the user U after medicine is delivered. For example, the information cooperation server 50A checks whether or not the user U is taking medicine as instructed by the pharmacist M, and if not according to the instruction, the information cooperation server 50A prompts the user U to take medicine as a follow-up. provide notices or prompt correction of incorrect usage or dosage; In addition, when the pharmacist M performs follow-up, the information cooperation server 50A may provide the pharmacist terminal device 40 with information necessary for the follow-up.
  • the pharmacist M in the online dosing guidance provided to the user U, instructs the user based on the user U's genetic information and health checkup data, including cautions about the side effects of the drug to be delivered. Able to give instructions on how to take the drug.
  • the pharmacist M can grasp the taking status (taking status) of the medicine issued to the user U, and can provide the user U with follow-up information as necessary. Since such medication guidance and follow-up can be performed online, according to the online dispensing system 100A of the embodiment, the quality of online medication guidance can be improved.
  • FIG. 1 exemplifies one user U as the user of the online dispensing system 100A for the sake of simplicity, this does not mean that there must be only one user of the online dispensing system 100A. . There may be a plurality of users of the online dispensing system 100A, and in that case, access to information regarding each user shall be appropriately controlled based on the identification information of each user.
  • FIG. 2 is a diagram showing an example of the functional configuration of the information linking server 50A.
  • the information linkage server 50A includes, for example, a linkage processing unit 51A, a configuration file generation unit 52, and a medication status monitor unit 53.
  • the link processing unit 51A has a function of linking various information among the genetic information server 10, the health checkup information server 20, the user terminal device 30 and the pharmacist terminal device 40.
  • FIG. 51A has a function of linking various information among the genetic information server 10, the health checkup information server 20, the user terminal device 30 and the pharmacist terminal device 40.
  • the cooperation processing unit 51A converts the user information and drug information of the user U into genetic information in response to the received side effect information provision request.
  • the genetic information server 10 and the health checkup information server 20 are requested to provide genetic data and health checkup data, respectively.
  • the cooperation processing unit 51A acquires the genetic data and health checkup data provided from the genetic information server 10 and the health checkup information server 20, and uses the acquired genetic data and health checkup data as side effect information. provided to the pharmacist terminal device 40.
  • the cooperation processing unit 51A receives configuration information provided from the pharmacist terminal device 40 as input, and cooperates with the configuration information that has been input to the configuration file generation unit 52, and inputs the configuration file that is provided from the configuration file generation unit 52. , and provides the input configuration file to the user terminal device 30 .
  • the config file is data for storing in the user terminal device 30 information related to online dosing guidance provided by the pharmacist M.
  • FIG. The config file is referenced by the user application as appropriate.
  • the configuration information is information necessary for generating a configuration file, and is information indicating the contents of the medication instruction given to the user U by the pharmacist M.
  • the configuration information includes information such as drug name, timing of administration, dosage, and precautions regarding side effects.
  • the content of the dosing instruction given to the user U is documented based on the config information and the config file, and sent to the user together with the drug. This increases the possibility that the user U will recognize that the side effect has occurred, so that the pharmacist M can detect the occurrence of the side effect at an early stage and quickly report it to the doctor D.
  • the cooperation processing unit 51A acquires information indicating the medication status of the user U from the user terminal device 30 in order to monitor the medication status of the user U after the medication is delivered. Record information indicating the status of taking U. For example, after receiving the medicine, the user U inputs the name of the medicine taken, the time of taking the medicine, the amount of medicine taken, the presence or absence of subjective symptoms, etc. to the user terminal device 30 as the medicine-taking status at the time of taking the medicine. . The user terminal device 30 notifies the input medication status to the information linkage server 50A. The cooperative processing unit 51A outputs the notified medication status to the medication status monitor unit 53 .
  • the configuration file generation unit 52 receives as input the configuration information provided by the cooperation processing unit 51A, and generates a configuration file based on the input configuration information.
  • the config file generation unit 52 provides the generated config file to the user terminal device 30, and manages the config file in association with the user U's user information.
  • the configuration file generator 52 is an example of a "setting information generator”.
  • a configuration file is an example of "setting information.”
  • the taking status monitor unit 53 has a database (hereinafter referred to as “taking status database”) for accumulating information indicating the taking status of the user U after the medicine is delivered.
  • taking status database a database for accumulating information indicating the taking status of the user U after the medicine is delivered.
  • the medication status monitor unit 53 accumulates information such as the name of the drug taken by the user U, the time the drug was taken, the dose of the drug taken, and the presence or absence of subjective symptoms due to medication as the medication status for each user U. .
  • the provision of the config file and the notification of the medication status have been described as being performed directly between the user terminal device 30 and the information linkage server 50A. Notification may be made via the pharmacist terminal device 40 .
  • the processing performed by the genetic information server 10 is divided into main processing of receiving a request from the information linkage server 50A and providing side effect information in response to the received request, and pre-processing performed in advance for this processing. .
  • the preprocessing is a process of generating a drug metabolism list for each user U.
  • the drug metabolism list is a compilation of drug metabolism information (hereinafter referred to as "metabolism information”) based on genetic information for various drugs.
  • the genetic information server 10 holds in advance a database relating to drug metabolism of various drugs (hereinafter referred to as "drug metabolism database"). Generate a list.
  • a drug metabolism list is an example of "list information”.
  • FIG. 3 is a flowchart showing an example of the flow of preprocessing performed by the genetic information server 10.
  • the genetic information server 10 performs preprocessing for all users U whose genetic information is registered in the server. For example, the genetic information server 10 may perform preprocessing at the timing when genetic information is registered for a user U whose genetic information has not been registered.
  • the genetic information server 10 acquires the genetic information of the user U from the genetic information accumulated by itself (step S101).
  • the genetic information server 10 determines whether or not any of the genetic polymorphisms of the user U is registered in the drug metabolism database (step S102).
  • the genetic information server 10 determines that some of the genetic polymorphisms of the user U are registered in the drug metabolism database (step S101-YES)
  • the registered genetic polymorphisms and their genetic polymorphisms and the contents of the side effects that the drug causes in the person having the gene polymorphism are registered in the drug metabolism list of user U (step S103), and the preprocessing is finished.
  • the genetic information server 10 determines that none of the genetic polymorphisms of the user U are registered in the drug metabolism database (step S101-NO)
  • the metabolic information is registered in the drug metabolism list of the user U. Terminate preprocessing without
  • FIG. 4 is a diagram showing a specific example of a drug metabolism list generated by preprocessing.
  • the drug metabolism list is generated in the form of a table including drug name, indication, trade name, and classification items.
  • the classification represents the classification of drugs classified according to usage, purpose, or the like.
  • the drug metabolism list may include other information related to the metabolic rate.
  • the metabolic rate represents an index of the rate at which the user U on the drug metabolism list metabolizes the drug, and is determined based on the user's U genetic information.
  • FIG. 5 is a diagram showing an example of other information related to metabolic rate.
  • relevant information may include information such as metabolic rate according to diplotype, reference information on dosing, and precautions.
  • a diplotype is information representing the type of genetic polymorphism.
  • Dosage references are primarily for physicians, such as higher doses for people with rapid metabolism.
  • the degree of caution represents the degree of caution regarding administration or taking of the drug. The degree of caution may be determined, for example, in terms of the possibility of side effects increasing if more drugs are administered to a person with a fast metabolizing rate.
  • FIG. 6 is a flowchart showing an example of the flow of this process performed by the genetic information server 10.
  • the genetic information server 10 starts the processing flow of FIG. 6 when receiving a request for provision of genetic data on the target user U from the information collaboration server 50A.
  • the genetic information server 10 acquires the user information and drug information of the user U from the information cooperation server 50A when requesting the provision of genetic data (step S201).
  • the information linkage server 50A receives a request for provision of side effect information from the pharmacist terminal device 40, and requests the genetic information server 10 to provide genetic data in response to the received request for provision of side effect information.
  • the information linking server 50A acquires the user information and the drug information of the user U from the pharmacist terminal device 40 when receiving the side effect information provision request, and sends it to the genetic information server 10 when the genetic data provision request is received. shall be provided.
  • the genetic information server 10 identifies the user U based on the acquired user information, and acquires the drug metabolism list of the user U from among the drug metabolism lists accumulated in its own server (step S202).
  • the genetic information server 10 determines whether or not any of the drugs indicated by the drug information is registered in the drug metabolism list of the user U (step S203).
  • the genetic information server 10 stores genetic information about the drug prescribed to user U. From the point of view of the above, the fact that there are no side effects (“no side effects”) is output to the genetic data (step S204).
  • step S203-YES if at least one of the drugs indicated by the drug information is registered in the drug metabolism list of user U (step S203-YES), the genetic information server 10 registers the drug information listed in the drug metabolism list. Output to genetic data (step S205).
  • FIG. 7 is a flowchart showing an example of the flow of processing in which the health checkup information server 20 generates health checkup data.
  • the health checkup information server 20 starts the processing flow of FIG. 7 when receiving a request for providing health checkup data for the target user U from the information linking server 50A.
  • the health checkup information server 20 acquires the user information and drug information of the user U from the information linking server 50A when requesting the provision of health checkup data (step S301).
  • the information linkage server 50A provides the health checkup information server 20 with the user information and drug information provided from the pharmacist terminal device 40 when receiving the side effect information provision request.
  • the health checkup information server 20 identifies the user U based on the acquired user information, and acquires the health checkup information of the user U from among the health checkup information accumulated in its own server (step S302). .
  • the health checkup information server 20 determines whether or not there is an abnormal value in the test result of the target health checkup item among the health checkup items indicated by the health checkup information of the user U (step S303). For example, the health checkup information server 20 determines whether there is an abnormal value in a numerical value related to liver function or renal function, which affects the ability to metabolize drugs. This is because some drugs may cause deterioration of liver function or renal function by taking them for a long period of time, and by providing such judgment results, pharmacist M can It can be issued to the user U more safely.
  • the health checkup information server 20 determines that there is no abnormal value in the test results of the target item (step S303-NO). If it is determined that there is no abnormal value in the test results of the target item (step S303-NO), the health checkup information server 20 indicates that there is no abnormal value in the health checkup information of the user U ("abnormal value "none") is output as health checkup data (step S304). On the other hand, if it is determined that an abnormal value exists in the test results of the target item (step S303-YES), the health checkup information server 20 outputs the health checkup information regarding the abnormal value to the health checkup data (step S305). .
  • FIG. 8 is a sequence diagram showing an example of the flow of processing executed by each server and each terminal device regarding online dosing guidance in the online dispensing system 100A.
  • a series of sequences are performed on the premise that the user U has been examined by the doctor D and has received a prescription from the doctor D.
  • the user terminal device 30 has acquired prescription data from the online medical examination system 60 at the start of the sequence.
  • the user U uses the user terminal device 30 to make a reservation for online dispensing with the information cooperation server 50A (step S401). For example, when making a reservation for online dispensing, the user terminal device 30 accepts input of various conditions such as the pharmacy at which dispensing is desired and the timing at which online medication guidance is desired. By transmitting to the cooperation server 50A, an application for online dispensing reservation is made.
  • the information cooperation server 50A allocates an online dispensing reservation to the user U and transmits the reservation information allocated to the user U to the pharmacist terminal device 40 (step S402).
  • the information linking server 50A shares in advance the scheduled implementation schedule of the online medication guidance with each pharmacy and each pharmacist M, and implements the online medication guidance in consideration of the implementation schedule and the desired conditions of the user U. Assign reservations.
  • the information linking server 50A may consider the user U's past usage history of the online dispensing service and registered location information (for example, address) when allocating a reservation for online medication guidance.
  • the pharmacist terminal device 40 acquires the prescription data related to the reserved online dispensing from the user terminal device 30 (step S403).
  • the pharmacist terminal device 40 generates drug information based on the acquired prescription data, and provides the generated drug information and the user information of the user U to the genetic information server 10 and the health checkup information server 20 via the information linkage server 50A. (step S404). Accordingly, the pharmacist terminal device 40 requests the genetic information server 10 to provide the genetic data about the user U, and requests the health checkup information server 20 to provide the health checkup data about the user U.
  • the genetic information server 10 Upon receiving the request in step S404, the genetic information server 10 generates genetic data for the user U according to the received request, and provides the generated genetic data to the information collaboration server 50A (step S405). Similarly, upon receiving the request in step S404, the health checkup information server 20 generates health checkup data for the user U according to the received request, and provides the generated health checkup data to the information linkage server 50A (step S406). ).
  • the linking processing unit 51A receives the genetic data provided from the genetic information server 10 and the health checkup data provided from the health checkup information server 20, and uses the input genetic data and health checkup data as side effect information. to the pharmacist terminal device 40 (step S407).
  • the pharmacist terminal device 40 provides online dosing guidance to the user U based on the genetic data and health checkup data acquired for the user U by the operation of the pharmacist M (step S408).
  • the pharmacist terminal device 40 provides the configuration information related to the online medication guidance to the information linkage server 50A (step S409).
  • the configuration file generating unit 52 receives the configuration information provided from the pharmacist terminal device 40, generates a configuration file based on the input configuration information, and sends the generated configuration file to the user terminal device 30. provided (step S410).
  • the configuration file generation unit 52 may be configured to store the generated configuration file without providing it at that time, and to provide the configuration file when receiving a provision request from the user terminal device 30. good. Also, the configuration file generation unit 52 may be configured to acquire configuration information or provide a configuration file via the pharmacist terminal device 40 .
  • FIG. 9 is a diagram showing a screen example of a pharmacist application that operates on the pharmacist terminal device 40.
  • the pharmacist application causes the display section of the pharmacist terminal device 40 to display a dosing guidance screen D1 as shown in FIG.
  • the dosing guidance screen D1 is a screen used when the pharmacist M gives the user U online dosing guidance.
  • the medication guidance screen D1 has, for example, a video conference area D11, a prescription image area D12, a prescription information input area D13, a side effect information area D14, and a configuration information area D15. Note that the functions of each area illustrated in FIG. 9 may be implemented by independent applications, or may be configured to be displayed on different screens.
  • the video conference area D11 is an area where the screen of the video conference held with the user terminal device 30 is displayed.
  • the pharmacist M uses the video conference function of the pharmacist application to make a voice call while displaying the image of the user U in the video conference area D11, thereby providing online medication guidance to the user U.
  • the prescription image area D12 is an area in which an image is displayed when image data of an imaged prescription is provided from the user terminal device 30 as prescription data.
  • the prescription information input area D13 is an area in which an input interface used by the pharmacist M to input the contents of the user's U prescription (prescription information) is arranged.
  • Prescription information includes drug information and user information.
  • the pharmacist M inputs user information and drug information into the prescription information input area D13 while looking at the prescription image displayed in the prescription image area D12.
  • Manual input by the pharmacist M is not essential in inputting the prescription information.
  • the pharmacist application may read the prescription information from the prescription image using a function such as OCR (Optical Character Recognition/Reader) and display it in the prescription information input area D13.
  • OCR Optical Character Recognition/Reader
  • the pharmacist application may be configured to accept input of operation for correcting the read information in the prescription information input area D13.
  • the pharmacist M can transmit the input user information and drug information to the genetic information server 10 and the health checkup information server 20 via the information linkage server 50A by pressing the send button. can.
  • the side effect information area D14 is an area where the contents of the genetic data provided by the genetic information server 10 and the health checkup data provided by the health checkup information server 20 regarding the user U are displayed.
  • the pharmacist M gives the online medication guidance to the user U, the pharmacist M confirms the contents displayed in the side effect information area D14, and determines the dose and dosage based on the possibility of side effects for the user U of each drug to be delivered. Guidance such as usage is given.
  • the configuration information area D15 is an area in which an input interface used by the pharmacist M to input the contents of the medication instruction provided to the user U by online medication instruction is arranged.
  • the pharmacist M during the online dosing guidance, provides the user U with dosing guidance for each drug while inputting the contents of the dosing guidance into the configuration information area D15.
  • pharmacist M completes the input of guidance content, he can send the input information as configuration information to information cooperation server 50A by pressing a send button.
  • the user terminal device 30 notifies the information cooperation server 50A of the medication status input by the user U (step S501).
  • the medication status monitor unit 53 inputs the medication status notified from the user terminal device 30, monitors whether the user U is taking the medicine correctly based on the input medication status, online dosing guidance for follow-up is implemented for the user U (step S502).
  • the medication status monitor unit 53 may notify the user terminal device 30 that the medication is forgotten when the medication status is not notified by a predetermined time for a given medication timing, or may notify the user terminal device 30 of the medication status at an unexpected timing. If so, the user terminal device 30 may be notified of the timing of taking medicine.
  • the medication status monitor unit 53 when the medication status monitor unit 53 is notified of an incorrect dosage or usage as the medication status, the medication status monitor unit 53 points out the error and sends a notification to the user terminal to prompt the user to take the medication with the correct dosage and usage. It may be sent to device 30 . Further, for example, the medication status monitor unit 53 accumulates the medication status notified from the user terminal device 30, and notifies the user terminal device 30 of advice, precautions, etc. assumed from the past medication history. may be configured. For example, the dosing status monitor unit 53 may be configured to notify information such as the total or average dose of each drug taken over a predetermined period.
  • FIG. 10 is a diagram showing a screen example of a user application that operates on the user terminal device 30.
  • the user application causes the display unit of the user terminal device 30 to display a medication notification screen D2 as shown in FIG.
  • the medicine notifying screen D2 is a screen for notifying the user U of the medicine taking timing.
  • the medication notification screen D2 has, for example, a medication information display area D21, a side effect information display area D22, and a medication situation input area D23.
  • the user application may display the medication notification screen D2 as a pop-up at the scheduled medication intake time.
  • the medication information display area D21 is an area in which information (hereinafter referred to as "medication information") related to medications that the user U is urged to take is displayed.
  • the medication information display area D21 shown in FIG. 10 is an example in which medication information prompting the taking of one tablet of Allegra is displayed.
  • the user application refers to the configuration file of the user U, identifies the drug that the user U should take at each timing, and displays information such as dosage and usage regarding the identified drug as medication information. It is displayed in area D21.
  • the side effect information display area D22 is an area in which side effect information related to drugs that the user U is urged to take is displayed.
  • the side effect information display area D22 shown in FIG. 10 indicates that a user U whose MDR1 gene is the ++ type may experience headache, nausea, drowsiness, abdominal pain, dizziness, and malaise when the person having the genotype takes Allegra.
  • This is an example of displaying side effect information indicating that side effects may occur, such as.
  • the user application refers to the configuration file of the user U, confirms whether or not there are side effects on the drug that prompts the user U to take the drug, and if there is a side effect, displays the side effect information in the side effect information display area D22. display.
  • the medication status input area D23 is an area in which an input interface for allowing the user U to enter the medication status is arranged.
  • the dosing status input area D23 shown in FIG. 10 includes a first check box for confirming that an appropriate dose of the presented drug has been taken, a second check box for confirming whether or not side effects have occurred, and a confirmation result.
  • a send button or the like is arranged for sending to the information cooperation server 50A.
  • the user application displays a first check box for each drug that prompts the user U to take the drug, at least to check the drug taking record, and if there is a side effect, to check the occurrence of the side effect. to display the second checkbox.
  • the send button when the send button is pressed, the user application sends the check result to the information linkage server 50A.
  • the information linkage server 50A updates the configuration file so as to reflect the new instructions and provides it to the user terminal device 30. may be configured.
  • the medication information display area D21, the side effect information display area D22, and the medication status input area D23 may be provided for each of the multiple medications.
  • online drug administration guidance at the time of drug delivery and online drug administration guidance for follow-up are alternately implemented, thereby providing the user U with a higher value-added online dispensing service.
  • the medication status monitor unit 53 compares the medication status notified by the user U with the configuration file of the user U to provide follow-up medication guidance.
  • the follow-up dosing instruction may be performed by the pharmacist M using the pharmacist terminal device 40 in the same manner as the first use.
  • FIG. 8 shows steps S601 to S604 of the same flow as the first time as the flow of online medication guidance for the second and subsequent times, but the online dispensing reservation is omitted in the second online medication guidance.
  • the user U uses the same pharmacy as at the time of first use, this is to allocate an online dispensing reservation upon provision of prescription data. In this way, for the second and subsequent use of the online dispensing service, some of the procedures and processes performed at the time of first use may be omitted.
  • a dosing status notification (step S603) is added. This is to notify the pharmacist terminal device 40 of the medication status recorded by the medication status monitor 53 in the previous monitoring. Guidance may be provided. In this way, the pharmacist M can, for example, notify the user U when the user U has taken the drug despite there was no concern about side effects from the viewpoint of genetic information in the past dosing guidance, or when the updated drug has been updated. If there is concern about side effects based on medical checkup information, etc., instructions for subsequent dosing can be given, including attention to side effects that may change over time.
  • the information linking server 50A performs information linking regarding the user U between the genetic information server 10 and the health checkup information server 20 and the pharmacist terminal device 40. provides side effect information based on user U's genetic information for a drug prescribed to user U.
  • personal information such as genetic data and health checkup data can be safely distributed by interposing the information linking server 50A in linking various types of information.
  • the pharmacist M can provide the user U with advice regarding the side effects of the drug to be delivered based on the genetic information and medical examination results in the online dosing guidance. The quality of instruction can be improved.
  • the pharmacist M when delivering the drug prescribed by the doctor D to the user U, the pharmacist M, based on the side effect information linked via the information linking server 50A, determines the gene related to drug metabolism such as CYP for the user U. After confirming the type, etc., and considering the possibility of side effects of the medicine to be delivered, administration guidance can be given. In addition to the genetic information, the pharmacist M also confirms the health checkup results of the user U to check whether there is any underlying disease that has been overlooked. Dosage guidance can be given after confirming that there is no effect on renal function. According to such online dosing guidance, it is possible to provide the user U with the advantage of prevention and early detection of side effects, so that the motivation of the user U to receive the online dispensing service can be improved.
  • FIG. 11 is a diagram showing a configuration example of an online dispensing system 100B according to a second embodiment of the medication instruction system of the present invention.
  • the online dispensing system 100B differs from the online dispensing system 100A according to the first embodiment in that it includes an information linkage server 50B in place of the information linkage server 50A and further includes a drug combination server 70 .
  • the configuration of the online dispensing system 100B is the same as that of the online dispensing system 100A except for the above. Therefore, here, the same reference numerals as in FIG. 1 are given to the same configurations, and the description thereof is omitted.
  • the drug combination server 70 provides information (hereinafter referred to as “drinking combination data") regarding side effects that may occur due to taking multiple drugs in combination (hereinafter also referred to as “drinking combination”).
  • the drug combination server 70 preliminarily holds a database relating to drug side effects due to drug combination (hereinafter referred to as “drug combination database”). It is assumed that information such as relevance to is accumulated.
  • the drug combination server 70 receives the drug information and genetic information provided via the information linkage server 50B as input, and searches the drug combination database based on the entered drug information and genetic information to create an arbitrary combination of drugs. It is possible to identify the presence or absence of side effects due to drinking together, and to acquire the details of the side effects.
  • the drug combination server 70 generates drug combination data based on such search results, and provides the generated drug combination data to the pharmacist terminal device 40 via the information linkage server 50B.
  • the drug combination server 70 is an example of a "third information acquisition unit”.
  • the drinking combination data is an example of the "third information”.
  • FIG. 12 is a diagram showing an example of the functional configuration of the information collaboration server 50B.
  • the information linking server 50B differs from the information linking server 50A in the first embodiment in that it includes a linking processing unit 51B instead of the linking processing unit 51A.
  • the configuration of the information linking server 50B is the same as that of the information linking server 50A except for the above. Therefore, here, the same components are denoted by the same reference numerals as in FIG. 2, and the description thereof is omitted.
  • the cooperative processing unit 51B acquires the drug combination data related to the drug prescribed to the user U from the drug combination server 70, and provides the acquired drug combination data to the pharmacist terminal device 40. It has the function to More specifically, when receiving a side effect information provision request for the user U from the pharmacist terminal device 40, the cooperation processing unit 51B obtains the genetic information of the user U from the genetic information server 10 in response to the received side effect information provision request. It acquires and provides the acquired genetic information to the drug combination server 70 together with the user information and the drug information. As a result, the cooperation processing unit 51B requests the drug combination server 70 to provide the drug combination data. The request for providing genetic data and health checkup data is the same as in the first embodiment. In response to these requests, the cooperation processing unit 51B requests genetic data, medical examination data, and drug combination data provided from the genetic information server 10, medical examination information server 20, and drug combination server 70, respectively, as side effect information. It is provided to the original pharmacist terminal device 40 .
  • FIG. 13 is a flowchart showing an example of the flow of processing performed by the drug combination server 70.
  • the drug combination server 70 starts the processing flow of FIG. 13 when receiving a request for providing drinking combination data for the target user U from the information linkage server 50B.
  • the drug combination server 70 acquires the user information, the drug information and the genetic information of the user U from the information linking server 50B in response to the received request for the provision of the drinking combination data. (Step S701).
  • the drug combination server 70 determines whether or not there is a possibility that the combination of drugs indicated by the drug information will cause side effects (step S702).
  • step S702-NO the drug combination server 70 notifies the user U that there are no side effects due to the drug prescribed to the user U (“no side effects”). Output to data (step S703).
  • step S702-YES the drug combination server 70 outputs information on possible side effects to the combination data (step S704).
  • the drug combination server 70 determines whether the combination of drugs prescribed to the user U has the possibility of side effects for the user U or a person having the same genotype as the user U (hereinafter referred to as "similar users"). It may be configured to determine based on the past dosage status of. For example, the drug combination server 70 acquires the past medication status of the user U or similar users from the medication status monitoring unit 53 of the information linkage server 50B, and based on the acquired medication status, the drug combination server 70 determines the number of medications that the user U or similar users have taken in the past. Extract combinations and the presence or absence of side effects in each combination.
  • the drug combination server 70 stores in advance a correspondence table that associates extracted combinations of drugs with the presence or absence of side effects in each combination, so that the combination of drugs prescribed to user U has been used by user U in the past. Alternatively, it can be determined whether or not there is a combination that has caused side effects to similar users.
  • the drug combination server 70 may include both the information obtained based on the combination database and the information obtained based on the correspondence table in the combination data.
  • the drug combination server 70 learns the relationship between the combination of drugs and the presence or absence of side effects by machine learning based on the past medication status of user U or a similar user, and uses the learning result to determine whether there are any side effects. It may be configured to estimate the presence or absence. In addition, in learning the relationship, the drug combination server 70 may be configured to learn not only the combination of drugs and the presence or absence of side effects, but also the relationship with the genetic information of user U or similar users.
  • FIG. 14 is a sequence diagram showing an example of the flow of processing executed by each server and each terminal device regarding online dosing guidance in the online dispensing system 100B.
  • the flow of processing shown in FIG. It differs from the flow of processing in the first embodiment (see FIG. 8) in that step S605 is added. Here, only points different from FIG. 8 will be described.
  • step S410 upon receipt of the side effect information provision request, the information linkage server 50B sends the genetic information acquired from the genetic information server 10 to the drug combination server 70 together with the user information and the drug information in response to the received side effect information provision request. It is a process to provide to It should be noted that step S605 is a process corresponding to step S410 when used for the second time or later.
  • Step S411 is a process in which the drug combination server 70 provides the information collaboration server 50B with the drinking combination data generated based on the genetic information and the drug information of the user U.
  • the drinking combination data provided by the information cooperation server 50B is provided to the pharmacist terminal device 40 as side effect information together with the genetic data and health checkup data.
  • Step S503 is a process of notifying the drug combination server 70 of the drug administration status using the user terminal device 30 when the user U takes a plurality of drugs. For example, when the user application notifies the dosing timings of a plurality of drugs on the dosing notification screen D2 similar to that shown in FIG. configured to notify In this way, the drug combination server 70 is able to accumulate information regarding the combination of drugs and the presence or absence of side effects for the user U, and use this information for learning.
  • the online dispensing system 100B of the second embodiment configured in this way, in addition to the side effect information based on genetic information and medical examination information, when a plurality of drugs to be taken at the same time are prescribed to the user U, , can further provide side-effect information about the combination. Therefore, the pharmacist M can provide higher-quality online dosing guidance.
  • the genetic information server 10 the health checkup information server 20, and the drug combination server 70 are independent and separate devices has been described. It may be aggregated in a server.
  • the server of the aggregation destination may be determined according to the security level of each server.
  • the information linkage server 50B acquires genetic information from the genetic information server 10 and provides it to the drug combination server 70. Some people think they don't like it.
  • the drug combination server 70 may be integrated into the genetic information server 10 so that the genetic information is not provided to the outside.
  • the online pharmacy system 100A including both the genetic information server 10 and the health checkup information server 20 is shown.
  • at least the genetic information server 10 may be provided.
  • the information cooperation server 50A may be configured to provide the pharmacist terminal device 40 with side effect information based on at least the user U's genetic information.
  • the online dispensing system 100B including all of the genetic information server 10, the health checkup information server 20, and the drug combination server 70 is shown. It is not necessary to have both the information server 20, and at least the genetic information server 10 should be provided.
  • the information linkage server 50B may be configured to provide the pharmacist terminal device 40 with side effect information based on at least the genetic data of the user U and the combination data.
  • the genetic information server 10, the health checkup information server 20, the user terminal device 30, the pharmacist terminal device 40, the information linking servers 50A and 50B, the online medical examination system 60, and the drug combination server 70 described above are, for example, CPUs (Central Processing Units). It is configured using a processor and memory such as. Each device functions as a device having the functions described above as a result of the processor executing the program. All or part of the configuration of each device may be implemented using hardware such as ASIC (Application Specific Integrated Circuit), PLD (Programmable Logic Device), FPGA (Field Programmable Gate Array), and the like.
  • the above program may be recorded on a computer-readable recording medium.
  • Computer-readable recording media include portable media such as flexible disks, magneto-optical disks, ROMs, CD-ROMs, semiconductor storage devices (such as SSD: Solid State Drives), hard disks and semiconductor storage built into computer systems. It is a storage device such as a device.
  • the above program may be transmitted via telecommunication lines.
  • the present invention can be applied to systems that deliver drugs online based on prescriptions.

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