WO2023030460A1

WO2023030460A1 - Spreading and staining machine, and spreading and staining method

Info

Publication number: WO2023030460A1
Application number: PCT/CN2022/116587
Authority: WO
Inventors: 周聪; 闫红力; 卢江涛; 吴照栋; 胡国松; 华德运
Original assignee: 深圳市瑞图生物技术有限公司
Priority date: 2021-09-01
Filing date: 2022-09-01
Publication date: 2023-03-09
Also published as: CN115541348A

Abstract

Provided in the present application are a spreading and staining machine and a spreading and staining method. The spreading and staining machine comprises: a reticulocyte staining apparatus, which is used for staining a reticulocyte sample; a sample addition apparatus, which is used for adding a stained reticulocyte sample onto a reticulocyte slide; and a spreading apparatus, which is used for smearing, on a reticulocyte slide, a reticulocyte sample added onto said reticulocyte slide. the present invention can implement slide preparation for a reticulocyte sample.

Description

Push-slide dyeing machine and push-slide dyeing method

technical field

The application relates to the technical field of medical devices, in particular to a slide dyeing machine and a slide dyeing method.

Background technique

In the diagnosis and treatment of diseases, after the samples are spread on the glass slides by pushing the slides, the samples are then stained to complete the preparation, and finally the test results obtained by microscopic examination provide a reference for the doctor to diagnose the disease. For example, microscopic examination of smear is the basic method of liquid cytology detection, which is widely used, especially for the diagnosis of various liquid diseases.

In the prior art, the invention patent application with the application number "202010144944.1" describes that the smear preparation device includes a slide loading module, a drop sample module, a slide module and a staining module arranged along the working line. The staining module is used to stain the smoothed slides after dropping the sample, that is to say, the patent application discloses the dyeing mode in which the samples are pushed first and then stained. This mode cannot Film production of reticulin samples.

Contents of the invention

The present application mainly provides a pusher dyeing machine and a pusher dyeing method, which can realize the preparation of reticulum samples.

The beneficial effects of the present application are: different from the situation of the prior art, the pusher dyeing machine provided by the present application includes: a reticulin dyeing device for dyeing a reticulin sample; a sample adding device for dyeing The reticulin sample is added to the reticulin glass slide; the pushing device is used for coating the reticulin sample on the reticulin glass slide, and can realize the preparation of the reticulin sample.

Description of drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following will briefly introduce the drawings that need to be used in the description of the embodiments. Obviously, the drawings in the following description are only some embodiments of the application. For those skilled in the art, other drawings can also be obtained based on these drawings without creative effort.

Fig. 1 is the schematic diagram of the three-dimensional structure of the embodiment of the pusher dyeing machine provided by the application;

Fig. 2 is a three-dimensional exploded structural schematic view of the pusher dyeing machine in Fig. 1 except for the shell;

Fig. 3 is a schematic block diagram of the position of the pusher dyeing machine in Fig. 1;

Fig. 4 is the schematic diagram of the three-dimensional structure of reticulin dyeing device and sample loading device in Fig. 2;

Fig. 5 is a schematic diagram of the three-dimensional structure of the pushing device in Fig. 2;

Fig. 6 is a schematic front view of the assembly of the push piece assembly and the carrying mechanism in Fig. 5;

Fig. 7 is a schematic diagram of the three-dimensional structure of the push piece assembly in Fig. 6;

Fig. 8 is a schematic diagram of an exploded structure of the clamping mechanism in Fig. 7;

Fig. 9 is a schematic diagram of the state in which the push piece in Fig. 7 is rotated to the pushing angle;

Fig. 10 is a schematic diagram of the state in which the push piece in Fig. 6 is rotated to the cleaning angle;

Fig. 11 is a schematic diagram of the state of the cleaning container in Fig. 10 moving to the avoidance position;

Fig. 12 is a schematic diagram of the cleaning state of the push piece in Fig. 10;

Fig. 13 is a schematic diagram of the three-dimensional structure of the dyeing device in Fig. 2;

Fig. 14 is the schematic diagram of the principle of the reticulan liquid adding device of the pusher dyeing machine in Fig. 1;

Fig. 15 is a schematic diagram of the principle of the conventional liquid feeding device of the pusher dyeing machine in Fig. 1;

Fig. 16 is a schematic perspective view of the three-dimensional structure of the delivery device in Fig. 2;

Fig. 17 is a schematic perspective view of the three-dimensional structure of the printing device in Fig. 2;

Fig. 18 is a schematic diagram of the three-dimensional structure of the sampling device in Fig. 2;

Fig. 19 is a schematic perspective view of the three-dimensional structure of the mixing device in Fig. 2;

Fig. 20 is a schematic perspective view of the three-dimensional structure of the container clamping device in Fig. 2;

Fig. 21 is a schematic diagram of the three-dimensional structure of the second manual sampling device in Fig. 1;

Fig. 22 is a schematic diagram of the three-dimensional structure of the embodiment of the slide transport device in Fig. 2;

Fig. 23 is a schematic diagram of the three-dimensional structure of the conveying platform in Fig. 22;

Fig. 24 is a schematic block diagram of an embodiment of the delivery platform in Fig. 23;

Fig. 25 is a schematic block diagram of another embodiment of the delivery platform in Fig. 24;

Fig. 26 is a schematic perspective view of the three-dimensional structure of the transmission unit in Fig. 23;

Fig. 27 is a schematic perspective view of the three-dimensional structure of the push assembly in Fig. 26;

Fig. 28 is a schematic diagram of the status of the pushing assembly in Fig. 27 in the receiving area R1 of the slide basket;

Fig. 29 is a schematic diagram of the state of the pushing assembly in Fig. 27 in the first slide receiving area R2;

Fig. 30 is a schematic diagram of the state of pushing the assembly back to the receiving area R1 of the slide basket in Fig. 29;

Fig. 31 is a schematic diagram of the inclined state of the push body in Fig. 30;

Fig. 32 is a schematic perspective view of the three-dimensional structure of the positioning assembly in Fig. 28;

Figure 33 is a schematic diagram of the initial state of the positioning assembly in Figure 32;

Fig. 34 is a schematic diagram of the process status of the positioning assembly in Fig. 32;

Fig. 35 is a schematic diagram of the initial state of the positioning assembly pushing the slide basket in Fig. 32;

Fig. 36 is a schematic diagram of the end state of the positioning assembly pushing the slide basket in Fig. 35;

Fig. 37 is a schematic diagram of the control of the slide dyeing machine in Fig. 1 .

Detailed ways

Please refer to FIG. 1 to FIG. 3 together. The pusher dyeing machine 10 includes a reticulin dyeing device 20 , a sample adding device 30 , a pusher device 40 , a dyeing device 50 and a conventional dyeing device 60 .

Please refer to Fig. 4, the reticulin dyeing device 20 is used for dyeing the reticulin sample, in actual application, earlier in the reticulin dyeing device 20, inject the reticulin dyeing reagent, by this reticulin dyeing reagent to The reticulin sample is dyed, and the reticulin staining reagent is the reticulin dye solution.

The sample loading device 30 includes a sample loading drive mechanism 31 and a sample loading piece 32. The sample loading drive mechanism 31 is connected with the sample loading piece 32 to drive the sample loading piece 32 to reciprocate. Position P1 and sample adding position P2, the reticulin staining device 20 is arranged on the reticulin dyeing position P1, and the sample adding part 32 is used to add the reticulin sample to the reticulin glass slide at the sample adding position P2, and/or Add the conventional sample to the conventional glass slide, that is, the sample-loading drive mechanism 31 drives the sample-loading part 32 to move to the reticulin staining position P1, and extracts the reticulin sample from the reticulin dyeing device 20, and then drives the sample-loading part 32 moves to the sample adding position P2 to add the reticulin sample to the reticulin glass slide. Similarly, the sample adding part 32 also adds the regular sample to the regular slide at the sample adding position P2.

It should be noted that the above-mentioned reticulin sample and routine sample can be the same sample, such as a cell sample, when the cell sample is used for reticulin detection, then the cell sample is a reticulin sample, when When the cell sample is used for routine detection, the cell sample is a routine sample; the above-mentioned reticulin sample and routine sample can also be different samples, such as a reticulin sample is a cell sample used for reticulin detection, and the routine The samples are either gynecological or andrological samples.

The sample loading drive mechanism 31 includes a first sample loading drive assembly 311 and a second sample loading drive assembly 312. The first sample loading drive assembly 311 is connected to the sample loading piece 32 to drive the sample loading piece 32 to move to the reticulin dyeing position respectively. P1 and the sample loading position P2, the second sample loading drive assembly 312 is respectively connected to the first sample loading drive assembly 311 and the sample loading piece 32, so as to drive the sample loading piece 32 away from or close to the reticulin staining device 20, conventional glass slides and/or Or reticulated glass slides, the first sample loading drive assembly 311 drives the sample loading piece 32 to move in the horizontal direction X, and the second sample loading drive assembly 312 drives the sample loading piece 32 to move in the vertical direction Z.

In this embodiment, both the first sample adding drive assembly 311 and the second sample add drive assembly 312 use a motor to drive the transmission belt to move. In other embodiments, other drive methods can also be used, such as cylinder drive, screw motor Drivers, etc., are not limited.

Please refer to Fig. 5, the pusher device 40 is used for coating the reticulin sample on the reticulated glass slide, and/or coating the conventional thin sample on the conventional glass slide, and in actual application, the reticulin glass slide and Conventional slides are all slides, and the reticulated slides and conventional slides in this embodiment are defined as different names only for the purpose of distinguishing them.

The pusher device 40 includes a carrying mechanism 41 , a pusher assembly 42 and a cleaning mechanism 43 . Wherein, the carrying mechanism 41 includes a stage 411 and a bracket 412, and the bracket 412 is arranged on the stage 411. Vertical setting.

Please refer to FIG. 6 to FIG. 8 together. The push piece assembly 42 is used for accommodating the push piece 300 . The push piece assembly 42 is installed on the bracket 412 , and an accommodating space 101 is formed between the push piece assembly 42 and the stage 411 . Wherein, the pushing piece assembly 42 includes a first pushing piece driving mechanism 426, the first pushing piece driving mechanism 426 is connected with the support 422 to drive the pushing piece 300 to reciprocate in the second moving direction, and the second moving direction is as shown in FIG. 7 The vertical direction Z shown. The first pusher driving mechanism 426 includes a motor 4261, a driving wheel 4262, a driven wheel 4263 and a transmission belt 4264. The driving wheel 4262 is connected to the output shaft of the motor 4261, and the transmission belt 4264 is wound around the driving wheel 4262 and the driven wheel 4263 and is connected to the support 422. Connected so that when the motor 4261 rotates, the drive belt 4264 drives the support 422 to move.

Further, the pushing piece assembly 42 also includes a second pushing piece driving mechanism 427, the second pushing piece driving mechanism 427 is connected with the first pushing piece driving mechanism 426 to drive the pushing piece 300 to reciprocate in the third moving direction, the third pushing piece driving mechanism 427 The moving direction is the horizontal direction Y as shown in FIG. 7 . Wherein, the structure of the second pushing piece driving mechanism 427 is the same as that of the above-mentioned first pushing piece driving mechanism 426 and will not be repeated here. The difference between the two is only that the second moving direction is different from the third moving direction.

Referring further to Fig. 5 and Fig. 6, the cleaning mechanism 43 includes a cleaning driving mechanism 431 and a cleaning container 432, the cleaning driving mechanism 431 is connected with the cleaning container 432 to drive the cleaning container 432 to reciprocate in a first moving direction, and the first moving direction is horizontal Direction X.

Wherein, accommodating position P3 and cleaning position P4 are provided along the movement track of cleaning container 432, and accommodating position P3 is arranged in accommodating space 101, so that cleaning container 432 cleans push piece 300 at cleaning position P4, and does not clean When the push piece 300 needs to be cleaned, the cleaning drive mechanism 431 drives the cleaning container 432 to the cleaning position P4. When cleaning is not required, the cleaning drive mechanism 431 drives the cleaning container 432 to move to the storage space In the space 101, on the one hand, the cleaning container 432 can be moved to reduce the movement stroke required for cleaning the push piece 300; A separate space is provided for installing the cleaning container 432, which reduces the volume of the entire device.

Please refer to Fig. 10 to Fig. 12 together, there is also an avoidance position P5 along the movement track of the cleaning container 432, and the accommodating position P3, the cleaning position P4 and the avoidance position P5 are arranged in sequence along the first moving direction X, so that the cleaning drive mechanism 431 drives the cleaning container 432 to move from the avoidance position P5 to the cleaning position P4, and drives the pushing mechanism 434 to drive the push piece 300 to rotate to the cleaning angle.

Specifically, when the push piece 300 needs to be cleaned, the cleaning drive mechanism 431 drives the cleaning container 432 to move from the accommodation position P3 as shown in FIG. 6 to the avoidance position P5 as shown in FIG. 11 , and the second push piece drive mechanism 427 drives the push piece 300 to move in the third moving direction Y to a position where it can be inserted into the cleaning container 432, that is, to move directly above the cleaning container 432, and then the first pushing piece driving mechanism 426 drives the pushing piece 300 in the second moving direction Z is close to the cleaning container 432 until as shown in FIG. During the movement of the avoidance position P5 to the cleaning position P4 as shown in Figure 12, the guide assembly 4216 abuts against the pushing mechanism 43, thereby driving the pushing piece 300 to rotate from the sample pushing angle as shown in Figure 12 to that shown in Figure 12 Finally, as shown in FIG. 12 , the first pusher driving mechanism 426 continues to drive the pusher 300 to insert into the cleaning container 432 in the second moving direction Z, and cleans the pusher 300 by an ultrasonic cleaning mechanism.

Furthermore, after the push piece 300 is cleaned, the first push piece driving mechanism 426 drives the push piece 300 away from the cleaning container 432 in the second moving direction Z until the push mechanism 4314 is out of contact with the guide assembly 4216 .

Further, the slide pushing device 10 also includes a slide conveying mechanism 44, the slide conveying mechanism 44 includes a slide carrying mechanism 441 and a slide driving mechanism 442, the slide carrying mechanism 441 is connected to the slide driving mechanism 442 and arranged on the guide rail 435 above, so that the slide driving mechanism drives the slide carrying mechanism 441 to reciprocate on the guide rail 435, so that the cleaning mechanism 43 and the slide conveying mechanism 44 share a guide rail 435. On the one hand, the use space of the whole device is saved, and the efficiency of the whole device is improved. Space utilization, on the other hand, reduces the conveying stroke of the slide conveying mechanism 44, and improves conveying efficiency.

The cleaning method of the pushing sheet in the present embodiment specifically includes:

S1: The cleaning drive mechanism drives the cleaning container to move from the accommodating position to the cleaning position;

S2: cleaning container cleaning push piece;

S3: The cleaning drive mechanism drives the cleaning container to move from the cleaning position to the accommodation position.

Please refer to FIG. 3 and FIG. 14 together. The staining device 50 is used to receive the stained glass slide 400, and the stained glass slide 400 is coated with a sample. In actual application, the sample can be coated on the stained glass by manual coating. slide 400, and then place the stained glass slide 400 on the staining device 50. It can be understood that the sample coated on the stained slide 400 is a stained sample that only needs to be stained to complete the preparation of the slide. The stained sample can include But not limited to andrological samples, gynecological samples, blood samples, etc., which are not limited.

Please refer to FIG. 2 and FIG. 3 together. The conventional staining device 60 is used to stain the stained glass slide 400 and/or the conventional slide, so that the pusher staining machine 10 in this embodiment can: add conventional samples sequentially And the pushing mode of coating on the conventional glass slide, the dyeing and pushing mode of coating the reticulin sample on the reticulin glass slide, the staining mode of staining the stained slide, adding and coating the conventional sample on the described Among the multiple modes for staining conventional slides, one or more modes can be arbitrarily selected for operation according to actual needs, which improves the applicability of the slide staining machine 10 . It should be noted that the push-slide mode refers to only adding and coating conventional samples on conventional glass slides without staining.

Please refer to FIG. 4 and FIG. 14 together. The pusher dyeing machine 10 also includes a reticulin adding device 70 , which is used for injecting a reticulin dyeing reagent into the reticulin dyeing device 20 . Wherein, net weaving red liquid adding device 70 comprises net weaving red liquid inlet pipe 701 and net weaving red power element 702, and net weaving red liquid inlet pipe 701 is communicated with reticulum dyeing device 20, and net weaving red power element 702 is connected with net weaving red The red liquid inlet pipe 701 is communicated, so as to extract the reticulin dyeing reagent through the reticulin liquid inlet pipe 701 and inject the reticulin dyeing reagent into the reticulin dyeing device 20 . Optionally, the reticulum power element 702 can be a peristaltic pump, a plunger pump, etc., which is not limited.

Please refer to FIG. 15 , the smear dyeing machine 10 also includes a conventional liquid feeding device 80 , which is used for injecting conventional dyeing reagents into the conventional dyeing device 60 , that is, injecting conventional dyeing reagents into the conventional dyeing container 61 .

Optionally, the conventional liquid adding device 80 includes a fixation module 84, a first cleaning module 85, and a second cleaning module 86. The fixation module 84 is used to inject the fixative into the conventional staining device 60, that is, inject the fixative into the sample fixation container 614, The first cleaning module 85 is used to inject the first cleaning solution into the conventional staining device 60 after the second staining of the stained slide and/or the conventional slide, that is, inject the first cleaning solution into the first cleaning container 615, and the second cleaning The module 86 is used for injecting the second cleaning solution into the conventional staining device 60 after the third staining of the stained slide and/or the regular slide, that is, injecting the second cleaning solution into the second cleaning container 616 .

Wherein, the fixed module 84 includes a fixed liquid inlet pipe and a fixed power element, the fixed liquid inlet pipe communicates with the sample fixing container 614, the fixed power element communicates with the fixed liquid inlet pipe, so as to extract the fixed liquid through the fixed liquid inlet pipe, and transfer the fixed liquid Inject the sample fixing container 614. In a specific application, the fixing liquid can be placed in the reagent barrel U, and the fixed liquid inlet pipe draws the fixing liquid from the reagent barrel U. The way that the fixed liquid inlet pipe communicates with the sample fixing container 614 can be fixed. The liquid inlet pipe is directly connected to the sample fixed container 614 to realize the communication between the two, or the fixed liquid inlet pipe is not connected to the sample fixed container 614, but is placed above the sample fixed container 614 in a suspended manner to realize both. connected. Optionally, the stationary power element may be a peristaltic pump, a plunger pump, etc., and the stationary liquid may be anhydrous methanol.

Further, the fixing module 84 is used to inject the fixative into the reticulin dyeing device 20, so as to clean the reticulin dyeing device 20 through the fixing liquid, and there is no need to additionally arrange other cleaning structures for cleaning the reticulin dyeing device 20 , simplifying the overall structure.

Specifically, the reticulin liquid adding mechanism 70 also includes a reticulin cleaning pipe 703, the reticulin cleaning pipe 703 communicates with the reticulin dyeing device 20, the fixed module 84 includes a fixed control element 843, and the fixed control elements 843 communicate with the network respectively. Weaving the red cleaning pipe 703 and the fixed liquid inlet pipe to control the conduction or non-conduction of the reticulin red cleaning pipe 703 and the fixed liquid inlet pipe, so as to select to inject the fixative liquid into the sample fixing container 614 or the reticulin dyeing device 20 . Optionally, the fixed control element 843 can be a solenoid valve.

Further, the conventional liquid adding device 80 also includes a third cleaning module 87, the third cleaning module 87 is used to clean the conventional dyeing container 61, in this embodiment, that is to clean the first dyeing container 611, the second dyeing container 612, At least one of the first cleaning container 615 and the third staining container 613 .

Further, the third cleaning module 87 is also communicated with the fixing module 81, so that when cleaning at least one of the first staining container 611, the second staining container 612, the first cleaning container 615, and the third staining container 613, it can Flexible selection of the above-mentioned cleaning solution or fixative solution.

Please refer to Fig. 3 and Fig. 16 together, push piece dyeing machine 10 also comprises conveying device 90, and conveying device 90 comprises conveying driving mechanism 91 and conveying carrying mechanism 92, conveying carrying mechanism 92 is used for carrying reticulate red slide and/or Or conventional glass slides, the transport driving mechanism 91 is connected with the transport carrying mechanism 92 to drive the transport carrying mechanism 92 to reciprocate.

Wherein, a sample loading position P2 and a slide pushing position P8 are provided along the movement track of the conveying and carrying mechanism 92, that is, when the conveying driving mechanism 91 drives the conveying and carrying mechanism 92 to move to the sample adding position P2, the sample adding device 30 will finish dyeing. Add the reticulated red sample to the reticulated red glass slide, and/or add the conventional sample to the conventional glass slide, then the conveying drive mechanism 91 drives the conveying and carrying mechanism 92 to move to the pushing position P8, and the pushing device 40 pushes the reticulated red sample Apply to reticulin slides, and/or apply routine samples to regular slides.

Wherein, the conveying driving mechanism 91 includes a first conveying driving assembly 911 and a second conveying driving assembly 912, and the first conveying driving assembly 911 and the second conveying driving assembly 912 are respectively connected with the conveying carrying mechanism 92 to respectively drive the conveying carrying mechanism 92 in Movement in the first direction K1 and the second direction K2.

Wherein, both the first conveying drive assembly 911 and the second conveying drive assembly 912 adopt a driving mode in which the motor drives the transmission belt to move, and then drives the conveying bearing mechanism 92 to move. In other embodiments, other driving modes can also be used, such as cylinder Drive, screw motor drive, etc., are not limited to this.

Further, the slide dyeing machine 10 also includes a transfer device 100, the transfer device 100 includes a transfer carrier mechanism 1001 and a first transfer drive mechanism 1002, the transfer carrier mechanism 1001 is used to receive the coated reticulated glass slide and/or For conventional glass slides, the first transfer driving mechanism 1002 is connected to the transfer carrying mechanism 1001 to drive the transfer carrying mechanism 1001 to reciprocate. Along the movement track of the transfer carrying mechanism 1001, a transfer receiving position P9 and a transfer clamping position P10 are provided.

Specifically, when the pusher 40 coats the reticulin sample on the reticulum glass slide, and/or coats the conventional sample on the conventional glass slide, it is necessary to coat the reticulin glass slide and/or the conventional slide Take it away, such as taking away the reticulated glass slide and performing reticulin detection on the reticulated glass slide, or staining the conventional slide after taking away the conventional slide, therefore, the first transport drive mechanism 1002 drives When the transfer carrier mechanism 1001 moves to the transfer receiving position P9, the transfer carrier mechanism 1001 receives the coated reticulated glass slides and/or conventional glass slides, and then drives the transfer carrier mechanism 1001 to move to the transfer clamping position P10, so that Reticulum slides and/or regular slides are removed at transfer clip pick-up position P10.

Further, the pusher dyeing machine 10 also includes a pusher 110, the pusher 110 includes a pusher drive mechanism 1101 and a pusher 1102, and the pusher drive mechanism 1101 is connected with the pusher 1102 to drive the pusher 1102 to weave the coated web Red slides and/or regular slides are pushed from the conveyance carrying mechanism 92 to the transfer carrying mechanism 1002. In this embodiment, the pushing drive mechanism 1101 drives the pusher 1102 in the first direction K1 to weave the coated mesh The red slides and/or regular slides are pushed from the transport carrying mechanism 92 to the transfer carrying mechanism 1002 .

Further, the transfer device 100 also includes a second transfer drive mechanism 1003, the second transfer drive mechanism 1003 is respectively connected with the first transfer mechanism 1001 and the transfer carrying mechanism 1002, so as to drive the transfer carrying mechanism 1002 to rotate to the receiving state and the clamping state respectively , that is, when the transfer carrier mechanism 1002 rotates to the receiving state, it can receive the mesh red glass slide and/or conventional glass slide pushed from the transport carrier mechanism 92, and when the transfer carrier mechanism 1002 rotates to the clamping state, the mesh Red woven slides and/or regular slides can be removed.

In actual application, when the red reticulated glass slide and/or the conventional glass slide are coated with the sample on the conveying and carrying mechanism 92, the red reticulated glass slide and/or the conventional glass slide are generally in a horizontal state, therefore, the above-mentioned receiving state is It is in a horizontal state, and in order to facilitate the clamping of reticulated red slides and/or conventional slides, reticulated red slides and/or conventional slides need to be in a vertical state, therefore, the above-mentioned clamping state is vertical state.

Specifically, a printing position P11 is also provided along the movement track of the conveying and carrying mechanism 92, and the printing device 120 is used to perform slide printing on at least one of reticulated glass slides, conventional slides and stained slides 400 at the printing position P11. , that is, when the conveying driving mechanism 91 drives the conveying and supporting mechanism 92 to move to the printing position P11, the printing device 120 performs slide printing on at least one of the reticulated glass slides, normal slides and stained slides 400 .

Wherein, when the reticulated glass slide and the conventional glass slide are printed, the conveying drive mechanism 91 drives the conveying carrying mechanism 92 to move to the sample loading position P2, and the sample adding device 30 will finish dyeing the reticulated red slide at the sample loading position P2. The sample is added to the reticulated glass slide, and/or the conventional sample is added to the conventional slide. After the sample addition is completed, the conveying drive mechanism 91 drives the conveying and carrying mechanism 92 to move to the pushing position P8, and the pushing device 40 is at the pushing position P8 Apply the reticulin sample to the reticulin slide, and/or apply the conventional sample to the conventional slide.

Further, since the stained slide 400 only needs to be stained, and does not need to be pushed, the stained slide 400 is not on the conveying and carrying mechanism 92 before printing, therefore, the stained slide 400 needs to be placed on the conveying On the carrying mechanism 92, the stained glass slide 400 can be clamped by the glass slide clamping mechanism 62 first, and the stained glass slide 400 is placed on the transfer device 100, and then the stained glass slide 400 is pushed from the transfer device 100 by the pushing device 110 To the conveying and carrying mechanism 92, its principle is the same as the above-mentioned principle of removing the red mesh slide and/or the conventional sample. 92 After receiving the stained glass slide 400, the conveying drive mechanism 91 drives the conveying and carrying mechanism 92 to move to the printing position P11 for slide printing. The stained slide 400 is removed in the same manner. It can be understood that the printing of the stained slide 400 can be performed before staining or after staining, which is not limited here.

In a specific application scenario, at least one of the stained glass slide, the conventional glass slide and the reticulated glass slide generally includes a printing area and a coating area, the coating area is used to coat the sample, and the printing device 120 prints the identification code information On the printing area, the placement position of at least one of the stained glass slides, conventional glass slides and reticulated red slides needs to match the movement direction of the carbon ribbon 500. Therefore, the detection unit 128 is used to detect the motor, take-up pulley and Sending the direction of rotation of at least one of the belt wheels, thereby detecting the orientation of the carbon ribbon 500, avoiding the mismatch between the orientation of the detection ribbon 500 and the placement position of at least one of the stained glass slides, conventional slides and reticulated red slides Problem with printing failure.

Further, the slide staining machine 10 also includes a slide storage device 130 , which is used for storing the slides and pushing the slides to the conveying and carrying mechanism 92 .

Specifically, there is also a slide receiving position P12 along the movement track of the conveying and carrying mechanism 92. When the conveying drive mechanism 91 drives the conveying and carrying mechanism 92 to move to the slide receiving position P12, the slide storage device 130 stores the slides 600 is pushed onto the conveying carrying mechanism 92, and then the conveying driving mechanism 91 drives the conveying carrying mechanism 92 to move to the printing position P11, so that the printing device 120 performs slide printing.

It can be understood that the glass slide can be the above-mentioned reticulated glass slide, or a conventional glass slide. The reticulated red glass slide and the conventional glass slide in this embodiment are only used to distinguish the two, and they are defined independently. In practice, both are glass slides.

Further, the slide storage device 130, the printing device 120, and the pusher device 40 are sequentially arranged along the first direction K1, and the pusher direction of the slide device 40 is the same as the first direction K1, which reduces the time required for the entire pusher dyeing machine. The size in the second direction K2 improves the rationality of the overall layout of the pusher dyeing machine 10 .

Please refer to Fig. 3 and Fig. 18 together, push piece dyeing machine 10 also comprises sampling device 130, and sampling device 130 is used for collecting reticulum sample and/or routine sample, and sampling device 130 is communicated with sample adding device 30, in specific application , the sampling device 130 can be communicated with the sample adding device 30 through a pipeline, so that the reticulin sample and/or conventional samples are injected into the sample adding device 30, and the reticulin sample is injected into the reticulin dyeing device 20 by the sample adding device 30 , and/or add regular samples to regular slides.

Wherein, the sampling device 130 includes a sampling drive mechanism 1301 and a sampling piece 1302, the sampling drive mechanism 1301 is connected with the sampling piece 1302, so as to drive the sampling piece 1302 away from or close to the reticulum container and/or the conventional container, so that the sampling piece 1302 collects the net Reticulum samples and/or conventional samples, and after the collection is completed, the sampling piece 1302 is away from the reticulum container and/or conventional container, in this embodiment, the sampling drive mechanism 1301 drives the sampling piece 1302 away from the reticulum container in the vertical direction Z. Or near a reticulum container and/or a regular container.

Please refer to Fig. 3 and Fig. 19 together, push piece dyeing machine 10 also comprises mixing device 150, and mixing device 150 comprises mixing driving mechanism 151 and mixing assembly 152, and mixing driving mechanism 151 is connected with mixing assembly 152 so that Drive the mixing assembly 152 to reciprocate, and the mixing assembly 152 is used to receive the reticulin container and mix the reticulin sample in the reticulin container, and/or receive the conventional container and carry out the routine sample in the conventional container For mixing, a first container receiving position P13 and a first sampling position P14 are provided along the movement track of the mixing component 12, and the sampling device 140 collects a reticulum sample and/or a regular sample at the first sampling position P14.

Further, the mixing assembly 152 includes a mixing power element 1521 and a mixing bearing element 1522, the mixing bearing element 1522 is used to carry a reticulum container and/or a conventional container, and the mixing power element 1521 is connected to the mixing bearing element 1522 , to drive the reticulin container and/or conventional container to swing, and then mix the samples in the reticulin container and/or conventional container.

Please also refer to Fig. 3 and Fig. 20, push piece dyeing machine 10 also comprises container clamping device 160, container clamping device 160 comprises, container clamping mechanism 161 is used for clamping reticulum container and /or conventional containers, the container driving mechanism 162 is connected with the container clamping mechanism 161 to drive the container clamping mechanism 161 to reciprocate, and the first container clamping position P15 and the first container receiving position are provided along the movement track of the container clamping mechanism 161 P13, the mixing assembly 152 is used to receive the reticulum container and/or conventional container at the first container receiving position P13, that is, the container clamping mechanism 161 clamps the reticulum container and/or at the first container clamping position P15 Conventional container, then place the reticulin container and/or conventional container on the mixing assembly 152 at the first container receiving position P13.

Wherein, the container drive mechanism 162 includes a first clamping drive assembly 1621 and a second clamping drive assembly 1622, and the second clamping drive assembly 1622 is respectively connected with the first clamping drive assembly 1621 and the container clamping mechanism 161, so that the second A gripping driving assembly 1621 drives the container gripping mechanism 161 to reciprocate in the vertical direction Z, and a second gripping driving assembly 1622 drives the container gripping mechanism 161 to reciprocate in the horizontal direction X.

Wherein, both the first clamping driving assembly 1621 and the second clamping driving assembly 1622 can be driven by screw motors, motor belts, cylinders, etc., which are not limited.

Further, the pusher dyeing machine 10 also includes an automatic sampling device 170, the sampling device 170 is used to transport the reticulum container and/or the conventional container to the first container clamping position P15, and the container clamping mechanism 161 is used for the second A container clamping position P15 clamps the reticulin container and/or the conventional container. In this embodiment, the automatic sampling device 170 sequentially transports a plurality of reticulin containers and/or a plurality of reticulin containers in the second direction K2. Regular container to first container gripping position P15.

Further, the slide dyeing machine 10 also includes a first manual sample feeding device 180 . Specifically, a second container clamping position P16 is also provided along the movement track of the container clamping mechanism 161, and the first manual sampling device 180 is used to receive the reticulin container and/or conventional container at the second container clamping position P16 , the container clamping mechanism 161 clamps the reticulin container and/or conventional container at the second container clamping position P16, it can be understood that the first manual sampling device 180 receives the reticulin container and/or conventional container in the following manner By means of manual placement, after the container clamping mechanism 161 clamps the reticulum container and/or the conventional container, it is placed on the mixing device 150 .

Generally, as described above, the automatic sampling device 170 sequentially transports a plurality of reticulin containers and/or a plurality of conventional containers to the first container clamping position P15, therefore, when a reticulin sample/or conventional sample needs to be When filming in a short period of time, that is, when there is an emergency sample, the reticulin container and/or the conventional container can be placed on the first manual sampling device 180, and there is no need to wait for the mixing device 160 to replace the automatic sampling device. The multiple reticulum containers and/or multiple conventional containers on the 170 are all mixed evenly before the emergency samples can be transported, which shortens the preparation time of the emergency samples.

Please refer to FIG. 3 and FIG. 21 together, the smear staining machine 10 further includes a second manual sampling device 190 .

Specifically, a second sampling position P17 is also provided along the movement track of the sample adding part 32, and the second manual sampling device 190 is used to receive the reticulum container and/or conventional container and transport it to the second sampling position P17, adding The sample 32 is used to collect a reticulum sample and/or a conventional sample at the second sampling position P17, so that the reticulum container and/or the conventional container can be transported to the second sampling position P17 without passing through the mixing device 160 , so that the sample adding device 30 collects the reticulin sample and/or the conventional sample, avoiding that when the reticulin sample/or conventional sample needs to be produced in a short time, that is, when an emergency sample occurs, the mixing device 160 has When the reticulin sample and/or the routine sample are being mixed, the mixing device 160 cannot transport the emergency sample to the sample loading position, resulting in the failure of the emergency sample to be produced, which shortens the production time of the emergency sample and improves the efficiency of emergency treatment. Sample production efficiency.

Wherein, the second manual sampling device 190 includes a sample introduction drive mechanism 191 and a sample introduction carrier mechanism 192, the sample introduction carrier mechanism 192 is used to receive the reticulin container and/or conventional container, the sample introduction drive mechanism 191 and the sample introduction carrier The mechanism 192 is connected to drive the movement of the sampling carrying mechanism 192, and a second sampling position P17 is provided along the movement track of the sampling carrying mechanism 192, that is, after the sampling carrying mechanism 192 receives the reticulum container and/or the conventional container, The sampling driving mechanism 191 transports the reticulin container and/or the conventional container to the second sampling position P17. In this embodiment, the sampling driving mechanism 191 drives the emergency carrying mechanism 192 to move in the second direction K2.

Further, the slide dyeing machine 10 also includes a housing 200, the housing 200 is formed with a housing space 201 and a sample inlet 202 communicating with the housing space 201, the above-mentioned sample feeding drive mechanism 191 is set in the accommodating space 201, And the sample loading mechanism 192 is driven to extend or shrink into the accommodating space 201 through the sample inlet 202 .

When the sample injection drive mechanism 191 drives the sample injection carrier mechanism 192 to extend out of the accommodating space 201 through the sample inlet 202, the reticulum container and/or the conventional container can be placed on the sample injection carrier mechanism 192 manually, Then the sample injection drive mechanism 191 drives the sample injection carrier mechanism 192 through the sample inlet 202 to extend and be accommodated in the accommodating space 201, and the sample loading device 30 will collect the reticulin sample and/or conventional sample, and improve the reticulin container and/or Or the convenience of regular container placement.

Please refer to Fig. 3, Fig. 22 to Fig. 24 together, the slide staining machine 10 also includes a slide transport device 210, the slide transport device 210 is used to transport the stained slides, in this embodiment, that is, transport At least one of the above-mentioned stained slides, reticulated slides and conventional slides, and the slides described below can be at least one of stained slides, reticulated slides and conventional slides. Wherein, the slide transport device 210 includes a transport platform 220 , a transport unit 230 and a positioning unit 240 .

Wherein, the conveying table 220 is formed with a first transport channel 401 extending along the first direction K1. It can be understood that the first direction K1 includes two sub-directions K11 and K12. Specifically, the conveying table 220 includes a bottom plate 221 and a plurality of Side plates, a plurality of side plates are installed on the bottom plate 221 to enclose the first transportation channel 401, as shown in Figure 23, a plurality of side plates include side plates 2221, side plates 2222, side plates 2223, side plates 2224 and side plates Board 2225.

Wherein, the first transport channel 401 includes a slide basket receiving area R1 and a first slide receiving area R2. It can be understood that the slide basket receiving area R1 is used to receive an empty slide basket 700, and the first slide receiving area R2 Used to receive slides, that is, the slides are inserted into the empty slide basket 700 in the first slide receiving area R2. In practical applications, the slides can be stained slides, and the stained slides It is gripped by a slide clamping mechanism 62 such as grippers and inserted into an empty slide basket 700 .

Optionally, the width H of the first transportation channel 401 perpendicular to the first direction K1 remains unchanged.

Please refer to FIG. 25, in this another embodiment, the width H1 of the slide basket receiving area R1 perpendicular to the first direction K1 is larger than the width H2 of the first slide basket receiving area R2, so that the slide basket receiving area R1 can receive When the slide basket 700 is actually used, as shown in FIG. 25 , it only needs to set the side plate 2225 obliquely relative to the first direction K1.

Specifically, both the slide basket receiving area R1 and the first slide receiving area R2 need to accommodate the slide basket 700. In practical applications, the width H2 of the first slide receiving area R2 must be greater than that of the slide basket 700. Width, and the width H1 of the slide basket receiving area R1 is set to be greater than the width H2 of the first slide receiving area R2, which further increases the area where the slide basket receiving area R1 can accommodate the slide basket 700 and improves the The basket receiving area R1 receives the convenience of the slide basket 700 .

Please refer to FIG. 23 and FIG. 26 together. The transfer unit 230 is used to transport the slide basket 700 from the slide basket receiving area R1 to the preset position of the first slide receiving area R2 in the first direction K1, that is, when empty. After the slide basket 700 is placed in the slide basket receiving area R1, the transmission unit 230 transports the slide basket 700 to the preset position of the first slide receiving area R2, so that the slide basket 700 is transported to the first slide basket During the process of receiving area R2, in the first direction K1, the position of the slide basket 700 in the first slide receiving area R2 is positioned by the transmission unit 230. It can be understood that the preset position of the first slide receiving area R2 The set position refers to a position where a slide can be inserted into the slide basket 700 .

Wherein, the transmission unit 230 includes a transmission drive mechanism 231 and a push assembly 232, the transmission drive mechanism 231 is connected to the push assembly 232, so that the transmission drive mechanism 231 drives the push assembly 232 to push the slide basket 700 from the slide basket receiving area R1 to the second A preset position of the slide receiving area R2, that is, in this embodiment, the transmission unit 230 transports the slide basket 700 by pushing. In this way, the push assembly 232 is always in contact with the slide basket during the pushing process. 700 is in a contact state. On the one hand, the transmission drive mechanism 231 only needs to drive the pushing assembly 232 to move in the first direction K1 according to the preset stroke, so that the slide basket 700 can be transported to the preset time of the first slide receiving area R2. Set the position, compared to other transmission methods, such as through the conveyor belt, and then place the slide basket 700 on the conveyor belt for transportation. Due to the frictional resistance between the slide basket 700 and the conveyor belt, the slide basket 700 may slip and other phenomena, resulting in that the slide basket 700 cannot be transported to the preset position of the first slide receiving area R2 after the transmission driving mechanism 231 drives the pushing assembly 232 to move in the first direction K1 according to the preset stroke. , the pushing component 232 can push the slide basket 700 to a position where it is attached to the side plate 223 , so that the position of the slide basket 700 can be positioned by the pushing component 232 and the side plate 223 . Therefore, the transport unit 230 transports the slide basket 700 by pushing, which can improve the accuracy of transporting the slide basket 700 to the aforementioned preset position.

Please refer to FIG. 27 to FIG. 29 together. The push assembly 232 includes a base 2321 and a push body 2322. The base 2321 is connected to the transmission drive mechanism 231. The base 2321 is connected to the first transmission belt 2314 and installed on the guide rail 2315. The push body 2322 is connected to the base. 2321 swivel connection. Wherein, the base 2321 or the pushing body 2322 is provided with a stop portion 2312a, the stop portion 2312a is disposed on the base 2321, and the stop portion 2312a is used to stop the push body 2322 when the push body 2322 pushes the slide basket 700.

Specifically, when the pushing assembly 232 pushes the slide basket 700 from the slide basket receiving area R1 to the first slide receiving area R2 along the sub-direction K11 as shown in FIG. 2322, prevent the pushing body 2322 from rotating relative to the base 2321 in the direction C1, so that during the pushing process, the pushing body 2322 is kept in contact with the slide basket 700, that is, the pushing body 2322 can always be kept in a vertical state.

30 and 31 together, the pushing body 2322 includes a pushing portion 2322a, a guiding portion 2322b and a rotating shaft 2322c. The pushing portion 2322a and the guiding portion 2322b are respectively arranged on opposite sides of the rotating shaft 2322c. In specific applications, the rotating shaft 2322c and the base 2321 Rotationally connected, the rotating shaft 2322c passes through the pushing body 2322 and is fixedly connected with the pushing body 2322, so that the pushing body 2322 forms the above-mentioned pushing part 2322a and guiding part 2322b. In other embodiments, the rotating shaft 2322c can also be fixed to the base 2321 Connection, the push body 2322 is rotationally connected with the rotating shaft 2322c.

Further, the gravitational moment M1 of the guide part 2322b is greater than the gravitational moment M2 of the pushing part 2322a. Specifically, when the pushing component 232 pushes the slide basket 700 to the first slide receiving area R2 as shown in FIG. 232 returns to the slide basket receiving area R1 in the sub-direction K12. As shown in FIG. The slide basket 700 in the basket receiving area R1 abuts, and the pushing body 2322 rotates in the direction B2 relative to the base 2321 under the abutting action, so that the pushing body 2322 turns from the vertical state shown in FIG. 30 To the tilted state as shown in FIG. 31 , the pushing assembly 232 continues to move in the sub-direction K12 until, as shown in FIG. 28 , the pushing part 2322a moves to the right side O2 of the slide basket 700 and disengages from the slide basket 700 At this time, since the gravitational moment M1 of the guide part 2322b is greater than the gravitational moment M2 of the pushing part 2322a, under the action of gravity, the pushing body 2322 rotates in the direction B1 relative to the base 2321, and then pushes the body 2322 from The tilted state is rotated to the vertical state as shown in Figure 28, so that the pushing assembly 232 can push the slide basket 700 from the slide basket receiving area R1 to the first slide receiving area R2 as described above, this way makes The pushing body 2322 does not need any other external force, and can push the plurality of slide baskets 700 from the slide basket receiving area R1 to the first slide receiving area R2 sequentially in a cyclic manner only by its own gravity.

Wherein, the gravitational moment M1=G1×L1 of the guide part 2322b, G1 is the gravity of the guide part 2322b, L1 is the distance between the center of gravity of the guide part 2322b and the rotating shaft 2322c, the gravitational moment M2 of the pushing part 2322a=G2×L2, G2 is the gravity of the pushing part 2322a, and L2 is the distance between the center of gravity of the pushing part 2322a and the rotating shaft 2322c.

Wherein, when the pushing body 2322 is in a vertical state to push the slide basket 700, the pushing part 2322a is located in the transport tank 211 and moves along the extending direction of the transport tank 211; when the pushing body 2322 is in an inclined state, the pushing part 2322a passes through the transport tank 211 rotates to below the slide basket 700.

Referring further to FIGS. 23 and 32, the positioning unit 240 includes a positioning drive mechanism 241 and a positioning assembly 242. The positioning drive mechanism 241 is connected to the positioning assembly to drive the positioning assembly 242 to push the slide basket 700, so that the slide basket 700 is in the second direction. K2 is pushed to the preset position of the first slide receiving area R2, so that the transmission unit 230 and the positioning unit 240 respectively position the slide basket 700 in the first direction K1 and the second direction K2, and the slide basket is improved. The accuracy of the position of the 700 receiving the slides in the first slide receiving area R2 avoids the inaccurate position of the slide basket 700 in the first slide receiving area R2, resulting in the situation that the slide cannot be inserted into the slide basket 700 .

Optionally, the second direction K2 is perpendicular to the first direction K1.

Please refer to Figure 28, Figure 32 to Figure 34 together, the positioning assembly 242 includes a first pusher 2421 and a second pusher 2422, the first pusher 2421 is fixedly connected to the positioning drive mechanism 241, the second pusher 2422 is connected to the first The pushing member 2421 is rotatably connected and used to push the slide basket 700 to a preset position in the first slide receiving area R2 in the second direction K2.

Specifically, after the slide basket 700 is transported to the first slide receiving area R2 by the transfer unit 230, the positioning drive mechanism 241 drives the positioning assembly 242 to move in the sub-direction K11 until, as shown in FIG. 31 , the second pusher 2422 moves to the right side O2 of the slide basket 700 and is in contact with the slide basket 700. At this time, the positioning assembly 242 continues to move, and the second pusher 2422 moves relative to the first pusher under the abutting action of the slide basket 700. 2421 rotates, so that the positioning assembly 242 can continue to move, and then as shown in FIG. , the slide basket 700 will be pushed in the second direction K2 by the positioning component 242 , and then the slide basket 700 will be pushed in the second direction K2 to the preset position of the first slide receiving area R2 .

In the above embodiment, the specific principle that the slide basket 700 is pushed in the second direction C by the positioning component 242 to the preset position of the first slide receiving area R2 in the first slide receiving area R2 is explained. In other embodiments In the process, the slide basket 700 may also be pushed to the first slide receiving area R2 in the second direction K2 by the positioning component 242 during the process of transporting the slide basket 700 from the slide basket receiving area R1 to the first slide receiving area R2. Set the position, for example, the positioning assembly 242 first pushes the slide basket 700 to a preset position in the second direction K2 in the first process area R5 shown in FIG. A process area R5 is transported to the first slide receiving area R2, the principle of which is the same as that described above, and will not be repeated here.

Further referring to Fig. 22 and Fig. 34, the conveying platform 220 is also formed with a second transport channel 402, the second transport channel 402 includes the second slide receiving area R3 and the slide basket output area R4, the second slide receiving area R3 and the second slide basket output area R4 One slide receiving area R2 is in communication, and the second slide receiving area R3 is in communication with the first slide receiving area R2 through the gap 403 .

Optionally, the second transportation channel 402 is arranged side by side with the first transportation channel 401. This arrangement can reduce the space occupied by the second transportation channel 402 in the direction perpendicular to the first direction K1. In this embodiment , that is, to reduce the occupied space in the direction of K2, so that the layout of the whole device is reasonable.

Wherein, the second slide receiving area R3 is used to receive the slide basket 700 inserted into the slide, that is, when the slide basket 700 is transported from the slide basket receiving area R1 to the first slide receiving area R2, the slide basket The slide basket 700 receives the insertion of slides at the preset position of the first slide receiving area R2, and then the slide basket 700 after inserting the slides is transported to the second slide receiving area R3.

Please refer to FIG. 32 , FIG. 35 and FIG. 36 together. The positioning drive mechanism 241 is also used to drive the positioning component 242 to push the slide basket inserted into the slide basket to the slide basket output area R4 .

As shown in FIG. 35 , after the pushing unit 250 pushes the slide basket 700 inserted with slides from the first slide receiving area R2 to the second slide receiving area R3, the positioning component 242 is located on the left side O1 of the slide basket 700 , at this time, the positioning drive mechanism 241 drives the positioning assembly 242 to move in the sub-direction K12, so that the first pusher 2421 of the positioning assembly 242 pushes the slide basket 700 inserted into the slide basket to the slide basket in the sub-direction K12 The output area R4 is used to complete the output of slides. It can be understood that the left side O1 of the slide basket 700 mentioned above is the same as the left side O1 of the slide basket 700 in FIG. 28 .

Optionally, the second pusher 2422 is stacked with the first pusher 2421. For example, the second pusher 2422 is arranged above the first pusher 2421 in the vertical direction Z. This arrangement can make the second pusher 2422 and the second pushing groove 2421a are jointly arranged with the slide basket 700, thereby improving the stability of pushing the slide basket 700 by increasing the depth of the second pushing groove 2421a in the vertical direction Z; or the second pushing member 2422 is stacked with the first pusher 2421, and the second pusher 2422 protrudes from the first pusher 2421 toward the side of the slide basket output area R4. This arrangement does not require the second pusher groove 2421a, only through The second pushing piece 2422 and the first pushing piece 2421 can achieve the same function as the second pushing slot 2421a.

Further, it has been explained above that the slide basket 700 is pushed up by the positioning component 242 in the second direction K2 to the preset position in the first slide receiving area R2 and the first process area R5 respectively. In yet another embodiment, as shown in FIG. 35 , the positioning component 242 may also be in the process of pushing out the slide basket 700 in the second slide receiving area R3 by the positioning component 242. Push the slide basket 700 in the first slide receiving area R2 to the preset position upward in the second direction K2 in the slide receiving area R3, or the positioning assembly 242 pushes the slide basket 700 in the first process area R5 in the second process area R6 The slide basket 700 is pushed to the preset position upward in the second direction K2, both of these two implementations and the implementation described above can realize that the positioning component 242 pushes the slide basket 700 to the first slide receiving area R2 The principle of the upward preset position of the second direction K2 is also the same, and will not be repeated here.

The slide transport methods provided by this application include:

S10: the transfer unit transports the slide basket from the slide basket receiving area to a preset position in the first slide receiving area in the first direction;

S11: The positioning drive mechanism drives the positioning assembly to push the slide basket, so that the slide basket is pushed to a preset position in the first slide receiving area in the second direction.

Please refer to FIG. 37 , the pusher dyeing machine 10 also includes a controller 260, the controller 260 is used to control the cleaning drive mechanism 431 to drive the cleaning container 432 to reciprocate in the first moving direction X, that is, the controller 260 is used to control the cleaning drive The mechanism 431 drives the cleaning container 432 to move from the storage position P1 to the cleaning position P2 to clean the push piece 300. After cleaning, the controller 260 controls the cleaning drive mechanism 431 to drive the cleaning container 432 to move from the cleaning position P2 to the storage position P1, the controller 260 controls the staining device to stain the pushed slides, that is, controls the conventional staining device 60 to stain the stained slides and/or conventional slides.

Further, the controller 260 is also used to control the transport unit 230 to transport the slide basket 700 from the slide basket receiving area R1 to the preset position of the first slide receiving area R2 in the first direction K1, the controller 260 is used to The positioning drive mechanism 241 is controlled to drive the positioning assembly 242 to push the slide basket 700, so that the slide basket 700 is pushed in the second direction C to a preset position in the first slide receiving area R2.

Further, the controller 260 is also used for:

Control the sample loading drive mechanism to drive the sample adding part to add the routine sample to the routine glass slide, and the pusher device to coat the routine sample on the routine slide; and/or

Control the reticulin dosing device to inject the reticulin dyeing reagent into the reticulin dyeing device, drive the sample adding drive mechanism to drive the sample adding part to add the reticulin sample to the reticulin glass slide, and the pushing device to apply the reticulin sample on reticulated glass slides; and/or

Controlling the conventional liquid adding device to inject the conventional staining reagent into the conventional staining device, so that the conventional staining device stains the stained glass slide; and/or

The sample adding drive mechanism is controlled to drive the sample adding part to add the routine sample to the routine glass slide, the slide pushing device coats the routine sample on the routine slide, and the routine liquid adding device injects the routine staining reagent into the routine staining device.

Push piece dyeing method one among the present embodiment comprises:

Staining the reticulin sample with a reticulin staining reagent, and staining a routine sample with a conventional staining reagent;

Extracting and clamping the stained reticulin sample from the reticulin staining device, adding the stained reticulin sample to the reticulin slide, and adding the routine sample to the routine slide;

The stained reticulin sample was spread on the reticulin glass slide, and the regular sample was spread on the regular slide.

Push piece dyeing method two in the present embodiment comprises:

Stain the reticulin sample by reticulin staining reagent;

Extracting and clamping the stained reticulin sample from the reticulin staining device, and adding the stained reticulin sample to the reticulin glass slide;

The stained reticulin sample was coated on a reticulin glass slide.

Different from the prior art, the pusher dyeing machine provided by this application includes: a reticulin dyeing device, which is used to dye a reticulin sample; a sample adding device, which is used to add the reticulin sample after dyeing onto the reticulated glass slide; the pusher device is used to coat the reticulated red sample on the reticulated glass slide, and can realize the preparation of the reticulated red sample.

Claims

A kind of pushing piece dyeing machine, it is characterized in that, described pushing piece dyeing machine comprises:

A reticulin dyeing device is used for dyeing a reticulin sample;

A sample adding device, for adding the stained reticulin sample to the reticulin glass slide;

The pusher device is used for coating the reticulin sample added on the reticulin glass slide on the reticulin glass slide.
Push slide staining machine according to claim 1, is characterized in that, described sample adding device can also be used for adding routine sample on routine glass slide; Described push slide device can also be used for described routine sample coating on the conventional glass slide.
The pusher dyeing machine according to claim 2, wherein the sample loading device comprises a sample loading drive mechanism and a sample loading piece, and the sample loading drive mechanism is connected with the sample loading piece to drive the sample loading The reciprocating motion of the piece is provided with a reticulin dyeing position and a sample adding position along the movement track of the sample adding piece;

Wherein, the reticulin dyeing device is arranged at the reticulin dyeing position, and the sample adding part is used for adding the dyed reticulin sample to the reticulin glass at the sample adding position. and/or, the sample adding drive mechanism drives the sample adding part to move the routine sample to the sample adding position, so as to add the routine sample to the routine glass slide.
The push piece dyeing machine according to claim 1, characterized in that, the push piece dyeing machine also includes a reticulin liquid adding device, and the retic red liquid adding device comprises a retic red liquid inlet pipe and a retic red liquid feeding device. A power element, the reticulin power element communicates with the reticulin liquid inlet pipe, so as to inject the reticulin red dyeing reagent into the reticulin dyeing device through the reticulin liquid inlet pipe.
The push piece dyeing machine according to claim 2, characterized in that, the push piece dyeing machine also includes a conveying device, the conveying device includes a conveying drive mechanism and a conveying carrying mechanism, and the conveying carrying mechanism is used to carry the The reticulated glass slide and/or the conventional slide are provided with a sample loading position and a slide pushing position along the movement track of the transport carrying mechanism, and the transport driving mechanism is connected with the transport carrying mechanism to drive the transport carrying mechanism The reciprocating movement between the sample adding position and the pushing film position.
Push piece dyeing machine according to claim 2, is characterized in that, described push piece dyeing machine also comprises:

Sampling device, the sampling device communicates with the sampling device, the sampling device is used to collect the reticulin sample, so that the reticulin sample is injected into the sampling device; and/or, the The sampling device is also used for collecting the routine sample, so as to inject the routine sample into the sample adding device.
The push piece dyeing machine according to claim 6, characterized in that, the push piece dyeing machine also comprises:

A mixing device, the mixing device is used to receive the reticulin container and mix the reticulin sample in the reticulin container, and the sampling device collects the reticulin in the mixing device sample; and/or, the mixing device is used to receive a regular container and mix the regular sample in the regular container, and the sampling device collects the regular sample in the mixing device.
The pusher dyeing machine according to claim 7, wherein the mixing device comprises a mixing drive mechanism and a mixing assembly, and the mixing drive mechanism is connected with the mixing assembly to drive the mixing The component reciprocates, and a first container receiving position and a first sampling position are set along the movement track of the mixing component;

The mixing component is used to receive the reticulin container and mix the reticulin sample in the reticulin container, and the sampling device collects the reticulin sample at the first sampling position; and /or,

The mixing component is used to receive a regular container and mix the regular sample in the regular container, and the sampling device collects the regular sample at the first sampling position.
Push piece dyeing machine according to claim 2, is characterized in that, described push piece dyeing machine also comprises:

A container gripping device, the container gripping device includes a container driving mechanism and a container gripping mechanism, the container driving mechanism is connected with the container gripping mechanism to drive the container gripping mechanism to move, along the The movement track is provided with a first container clamping position and a first container receiving position, and the container clamping mechanism clamps a reticulum container and/or a conventional container at the first container clamping position.
The push piece dyeing machine according to claim 9, characterized in that, the push piece dyeing machine also comprises:

A mixing device, the mixing device is used to receive the reticulin container at the first container receiving position and mix the reticulin sample in the reticulin container; and/or, the mixing The device is used for receiving a regular container at the first container receiving position and mixing the regular sample in the regular container.
The push piece dyeing machine according to claim 9, characterized in that, the push piece dyeing machine also comprises:

An automatic sampling device, the automatic sampling device is used to transport the reticulin container and/or the conventional container to the clamping position of the first container; and/or,

The first manual sampling device is also provided with a second container clamping position along the movement track of the container clamping mechanism, and the first manual sampling device is used to receive the manual placement at the second container clamping position The reticulum container that is placed in the manner, the container gripping mechanism grips the reticulum container at the second container gripping position; and/or, the first manual sampling device is used for The second container clamping position receives a conventional container placed manually, and the container clamping mechanism clamps the conventional container at the second container clamping position; and/or,

The second manual sampling device, the second manual sampling device is used to receive the reticulum container and transported to the second sampling position, and the sampling device is used to collect reticulin at the second sampling position sample; and/or, the second manual sampling device is used to receive a regular container and transport it to a second sampling position, and the sampling device is used to collect a regular sample at the second sampling position.
The pusher dyeing machine according to claim 5, characterized in that, the pusher dyeing machine also includes a transfer device, the transfer device includes a transfer carrier mechanism and a transfer drive assembly, and the transfer carrier mechanism is used to receive the coating After completion of the reticulated slide and/or conventional slide, the transport drive mechanism is connected to the transport carrying mechanism to drive the transport carrying mechanism to and fro; and/or, the transport drive mechanism drives the transport The carrying mechanism rotates to the receiving state and the clamping state respectively;

Pushing device, described pushing device comprises pushing driving mechanism and pushing piece, and described pushing driving mechanism is connected with described pushing piece, to drive described pushing piece to coat the described reticulated glass slide and/or conventional The slides are pushed from the transport carrying mechanism to the transfer carrying mechanism.
The pusher dyeing machine according to claim 5, characterized in that, the pusher dyeing machine also includes a printing device, and a printing position is also provided along the movement track of the conveying and carrying mechanism, and the conveying drive mechanism drives the When the conveying and carrying mechanism moves to the printing position, the printing device performs slide printing on the reticulated glass slide and/or regular slide at the printing position.
The push slide staining machine according to claim 2, characterized in that, the push slide stainer also includes a slide transport device, the slide transport device is used to transport the stained slides, and the slide transport Devices include:

The transport platform is formed with a first transport channel extending along the first direction, and the first transport channel includes a slide basket receiving area and a first slide receiving area;

a transport unit, configured to transport the slide basket from the slide basket receiving area to a preset position in the first slide receiving area in the first direction;

The positioning unit includes a positioning drive mechanism and a positioning component, the positioning drive mechanism is connected with the positioning component to drive the positioning component to push the slide basket, so that the slide basket is pushed in the second direction to the The preset position of the first slide receiving area.
Push piece dyeing machine according to claim 14, is characterized in that,

The conveying platform is also formed with a second transport channel, the second transport channel includes a second slide receiving area and a slide basket output area, the second slide receiving area communicates with the first slide receiving area to receive the slide basket inserted with slides, the positioning drive mechanism is also used to drive the positioning assembly to push the slide basket inserted with slides to the output area of the slide basket, and the second transportation channel is connected with The first transport lanes are arranged side by side; and/or,

The positioning assembly includes a first pusher and a second pusher, the first pusher is fixedly connected to the positioning drive mechanism and is used to push the slide basket inserted into the slide basket to the output area of the slide basket, The second pusher is rotatably connected to the first pusher and used to push the slide basket to the preset position in a second direction; and/or;

The transmission unit includes a transmission drive mechanism and a push assembly, the transmission drive mechanism is connected to the push assembly to push the slide basket from the slide basket receiving area to the preset position;

The push assembly includes a base and a push body, the base is fixedly connected to the transmission drive mechanism, the push body is rotatably connected to the base, and a stopper is provided on the base or the push body for When the pushing body pushes the slide basket, it stops the pushing body;

The pushing body includes a pushing part, a guiding part and a rotating shaft. The pushing part and the guiding part are respectively arranged on opposite sides of the rotating shaft. The gravity moment of the guiding part is greater than that of the pushing part.
The sheet-pushing dyeing machine according to claim 2, wherein the sheet-pushing device comprises:

The bearing mechanism includes a carrier and a bracket, and the bracket is arranged on the carrier;

A push piece assembly is used to accommodate the push piece, the push piece assembly is installed on the bracket, and an accommodating space is formed between the push piece assembly and the carrier;

The cleaning mechanism includes a cleaning driving mechanism and a cleaning container, the cleaning driving mechanism is connected to the cleaning container to drive the cleaning container to reciprocate in the first moving direction;

Wherein, a cleaning position and an accommodating position are provided along the movement track of the cleaning container, and the accommodating position is set in the accommodating space, so that the cleaning container cleans the push piece at the cleaning position and It is accommodated in the accommodating space when it is not cleaned.
The pushing piece dyeing machine according to claim 16, wherein the pushing piece assembly includes a clamping mechanism and a support, and the clamping mechanism is used to clamp the pushing piece and is rotatably connected with the support , the cleaning mechanism also includes a pushing mechanism connected to the cleaning driving mechanism, the cleaning driving mechanism is used to drive the pushing mechanism to drive the push piece to rotate to a cleaning angle;

Wherein, an avoidance position is also provided along the movement track of the cleaning container, the accommodating position, the cleaning position and the avoidance position are sequentially arranged along the first moving direction, and the cleaning drive mechanism is used to drive the During the process of the cleaning container moving from the avoidance position to the cleaning position, the pushing mechanism is driven to drive the push piece to rotate to the cleaning angle.
The push piece dyeing machine according to claim 17, wherein the push piece assembly further comprises:

A first push piece drive mechanism, the first push piece drive mechanism is connected with the support to drive the push piece to insert into the cleaning container in the second moving direction, and the first push piece drive mechanism is also used for driving the clamping mechanism to move in the second moving direction to the motion track of the pushing mechanism;

A second push piece driving mechanism, the second push piece driving mechanism is connected with the first push piece driving mechanism to drive the push piece to move to an insertable position in a third moving direction.
Push piece dyeing machine according to claim 2, is characterized in that, described push piece dyeing machine also comprises:

A conventional staining device, the conventional staining device is used for staining the conventional slide;

The pusher dyeing machine includes at least one of the following operating modes:

Slider mode: the sample loading device adds the routine sample to the routine slide, and the pusher applies the routine sample to the routine slide;

Reticulin sample dyeing and pushing mode: the reticulin adding device injects the reticulin dyeing reagent into the reticulin dyeing device; The reticulated red sample is coated on the described reticulated red glass slide;

Conventional sample dyeing and pushing mode: the sample loading device applies the conventional sample to the conventional glass slide, the slide device applies the conventional sample to the conventional glass slide, and the conventional liquid adding device injects the conventional staining reagent into the conventional staining device ;

Total dyeing push mode: the reticulin dosing device injects the reticulin dyeing reagent into the reticulin dyeing device, and the conventional dosing device injects the conventional dyeing reagent into the conventional dyeing device; the sample adding device adds the reticulin sample to the reticulin On the glass slide, the conventional sample is coated on the conventional glass slide, and the reticulin sample is coated on the reticulin glass slide by the pusher device, and the conventional sample is coated on the conventional glass slide.
A kind of pushing piece dyeing machine, it is characterized in that, described pushing piece dyeing machine comprises:

A reticulin dyeing device is used for dyeing a reticulin sample;

A sampling device for extracting or clamping the stained reticulin sample from the reticulin dyeing device, and adding the stained reticulin sample to the reticulin glass slide, adding conventional Samples are added to regular slides;

Pusher, for coating the reticulin sample on the reticulin glass slide and/or coating the routine sample on the regular slide;

The pusher dyeing machine includes at least one of the following operating modes:

Slider mode: the sample loading device adds the routine sample to the routine slide, and the pusher applies the routine sample to the routine slide;

Reticulin sample dyeing and pushing mode: the reticulin adding device injects the reticulin dyeing reagent into the reticulin dyeing device; The reticulated red sample is coated on the described reticulated red glass slide;

Total dyeing push mode: the reticulin dosing device injects the reticulin dyeing reagent into the reticulin dyeing device, and the conventional dosing device injects the conventional dyeing reagent into the conventional dyeing device; the sample adding device adds the reticulin sample to the reticulin On the glass slide, the conventional sample is coated on the conventional glass slide, and the reticulin sample is coated on the reticulin glass slide by the pusher device, and the conventional sample is coated on the conventional glass slide.
A kind of pushing piece dyeing machine, it is characterized in that, described pushing piece dyeing machine comprises:

A reticulin dyeing device is used for dyeing a reticulin sample;

A sample adding device, used to extract the stained reticulin sample from the reticulin staining device, and add the stained reticulin sample to the reticulin glass slide, and add the conventional sample to the reticulin glass slide. on regular slides;

Pusher, for coating the reticulin sample on the reticulin glass slide, and coating the sample on the conventional glass slide;

A conventional staining device, used for staining the conventional slide;

The pusher dyeing machine includes at least one of the following operating modes:

Slider mode: the sample loading device adds the routine sample to the routine slide, and the pusher applies the routine sample to the routine slide;

Reticulin sample dyeing and pushing mode: the reticulin adding device injects the reticulin dyeing reagent into the reticulin dyeing device; The reticulated red sample is coated on the described reticulated red glass slide;

Conventional sample dyeing and pushing mode: the sample loading device applies the conventional sample to the conventional glass slide, the slide device applies the conventional sample to the conventional glass slide, and the conventional liquid adding device injects the conventional staining reagent into the conventional staining device ;

Total dyeing push mode: the reticulin dosing device injects the reticulin dyeing reagent into the reticulin dyeing device, and the conventional dosing device injects the conventional dyeing reagent into the conventional dyeing device; the sample adding device adds the reticulin sample to the reticulin On the glass slide, the conventional sample is coated on the conventional glass slide, the reticulin sample is coated on the described reticulin glass slide by the pushing device, and the conventional sample is coated on the conventional glass slide;

Staining mode: The conventional staining device stains the stained slides.
A kind of method for staining of push piece, it is characterized in that, comprises:

Stain the reticulin sample by reticulin staining reagent;

Extracting and clamping the stained reticulin sample from the reticulin staining device, and adding the stained reticulin sample to the reticulin glass slide;

The stained reticulin sample was coated on a reticulin glass slide.
A kind of method for staining of push piece, it is characterized in that, comprises:

Staining the reticulin sample with a reticulin staining reagent, and staining a routine sample with a conventional staining reagent;

Extracting and clamping the stained reticulin sample from the reticulin staining device, and adding the stained reticulin sample to the reticulin slide, and adding the routine sample to the routine slide;

The stained reticulin sample was coated on the reticulin slide, and the conventional sample was coated on the conventional slide.