WO2023020817A1 - Composition de soin buccal comprenant du iota carraghénane et du kappa carraghénane - Google Patents

Composition de soin buccal comprenant du iota carraghénane et du kappa carraghénane Download PDF

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Publication number
WO2023020817A1
WO2023020817A1 PCT/EP2022/071514 EP2022071514W WO2023020817A1 WO 2023020817 A1 WO2023020817 A1 WO 2023020817A1 EP 2022071514 W EP2022071514 W EP 2022071514W WO 2023020817 A1 WO2023020817 A1 WO 2023020817A1
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WO
WIPO (PCT)
Prior art keywords
oral care
pigment
care composition
composition according
carrageenan
Prior art date
Application number
PCT/EP2022/071514
Other languages
English (en)
Inventor
Long GAO
Huajin Jin
Weining LIU
Jinfang Wang
Original Assignee
Unilever Ip Holdings B.V.
Unilever Global Ip Limited
Conopco, Inc., D/B/A Unilever
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Ip Holdings B.V., Unilever Global Ip Limited, Conopco, Inc., D/B/A Unilever filed Critical Unilever Ip Holdings B.V.
Priority to EP22758223.6A priority Critical patent/EP4387586A1/fr
Publication of WO2023020817A1 publication Critical patent/WO2023020817A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/594—Mixtures of polymers

Definitions

  • the present invention relates to oral care compositions comprising pigments and polymers that enhance the white appearance of teeth.
  • the invention is also concerned with the use of such compositions for whitening teeth of an individual.
  • the enamel layer of the tooth is naturally an opaque white or slightly off-white colour. However, this enamel layer can become stained or discoloured. Many products we consume have a negative impact on our teeth and mouth. Many substances can stain or reduce the whiteness of one’s teeth, in particular, certain foods, tobacco products, and fluids such as tea and coffee. These staining and discolouring substances are often able to permeate the enamel layer. This problem occurs gradually over many years, but imparts a noticeable discoloration of the enamel of one’s teeth.
  • an oral care composition comprising certain types of carrageenan and anionic surfactants can enhance the deposition of pigments on tooth surfaces to provide instant tooth whitening benefit.
  • the present invention is directed to an oral care composition
  • an oral care composition comprising: (a) iota carrageenan;
  • the present invention is directed to a packaged oral care product comprising the oral care composition of the first aspect of this invention.
  • the present invention is directed to a method of whitening teeth of an individual comprising the step of applying the oral care composition of any embodiment of the first aspect to at least one surface of the teeth of the individual.
  • Carrageenan is a family of linear sulfated polysaccharides that are obtained by alkaline extraction from some species of red seaweeds.
  • Carrageenan is formed by disaccharide repeating unit which consists of alternating 3-linked p-d-galactopyranose or 4-linked a-d- galactopyranose or 4-linked 3,6-anhydro-a-d-galactopyranose.
  • the types of carrageenan may be distinguished by their degree of sulfation.
  • Suitable carrageenans for use in the present invention are iota and kappa carrageenan.
  • the iota carrageenan and the kappa carrageenan in the compositions of the present invention are present in a weight ratio of from 1 :20 to 10: 1 , more preferably from 1 :10 to 5:1 and most preferably from 1 :5 to 3:1.
  • lota carrageenan or kappa carrageenan is commercially available, for example, from CP Kelco.
  • the total amount of iota and kappa carrageenan in the composition is preferably from 0.01 to 10% by weight of the composition, more preferably from 0.02 to 5% and most preferably from 0.05 to 3%, based on total weight of the oral care composition and including all ranges subsumed therein.
  • the oral care composition of the present invention is substantially free of other carrageenans in addition to the iota and kappa carrageenans which are included in the composition.
  • “Substantially free of”, as used herein, means less than 0.05%, preferably less than 0.01%, more preferably less than 0.005%, and more preferably still less than 0.001% and most preferably from 0 to 0.001% by weight, based on total weight of the oral care composition, including all ranges subsumed therein. It is particularly preferred if the oral care composition of the present invention does not comprise other carrageenans in addition to the iota and kappa carrageenans.
  • the anionic surfactant suitable for use in the present application includes, for example, sodium, potassium, ammonium, substituted ammonium salts of Cs-C alkyl sulfates (for example sodium lauryl sulfate) or Cs-C ethoxylated alkyl sulfates (for example sodium lauryl ether sulfate), Cs to C alkyl sulphosuccinates (for example dioctyl sodium sulphosuccinate), Cs to C alkyl sulphoacetates (for example sodium lauryl sulphoacetate), Cs to C alkyl sarcosinates (for example sodium lauryl sarcosinate), Cs to C alkyl phosphates (which can optionally comprise up to 10 ethylene oxide and/or propylene oxide units) and sulphated monoglycerides, preferably the anionic surfactant is sodium, potassium, ammonium, substituted ammonium salts of alkyl
  • the anionic surfactant is preferably present at a level of from 0.01 to 15% by weight of the composition, more preferably from 0.1% to 10%, most preferably from 0.5% to 7%, based on total weight of the oral care composition and including all ranges subsumed therein.
  • the composition also comprises a pigment.
  • the pigment according to the invention is a shade/material which is insoluble in the relevant medium, at the relevant temperature. This is in contrast to dyes which are soluble.
  • soluble means a source that dissolves in water to give a solution with a concentration of at least 0.1 moles per litre.
  • relevant medium refers to human saliva, the liquid medium in which the composition is used, at the temperature of the oral cavity during brushing of the teeth, i.e. up to 37°C.
  • the relevant medium may also be water and the relevant temperature to be 25°C.
  • the only limitation with respect to the pigment is that the same is suitable for use in the mouth.
  • the pigment has a hue angle, h, in the Cl ELAB system of from 220 to 320 degrees, more preferably from 250 to 290 degrees.
  • hue angles may be found on p57 of Colour Chemistry 3 rd edition by H. Zollinger published by Wiley-VCH.
  • the pigment is violet or blue, more preferably the pigment is selected from one or more of those listed in the Colour Index International as pigment blue 1 through to pigment 83 and pigment violet 1 through to pigment violet 56.
  • Other suitable pigments are pigment ultramarine blue and ultramarine violet. While the preferred pigment is blue or violet, the same effect may be achieved through mixing pigments outside of this hue angle range. For example, such a hue angle may also be obtained by mixing a red and green-blue pigment to yield a blue or violet shaded pigment.
  • the pigment is a blue pigment.
  • blue pigments suitable for use in this invention include inorganic blue pigments such as iron blue (C.l. 77510) and ultramarine blue (C.l. 77007).
  • a preferred class of blue pigments suitable for use in the invention are organic blue pigments such as phthalocyanine blue pigments.
  • Phthalocyanines are organometallic compounds containing four symmetrically arranged isoindole rings connected in a 16-membered ring linking with alternate carbon and nitrogen atoms. Most phthalocyanines contains a central, coordinated metal ion such as copper. Copper phthalocyanines have the basis structure:
  • Phthalocyanine blue pigments exhibit more than one crystal modification, which differ in terms of coloristics. Methods have been developed to phase-stabilise the phthalocyanine pigment molecule in order to prevent conversion to a different crystal modification. An example is minor chemical modification of the molecule, for instance partial chlorination. Methods have also been developed to stabilise the phthalocyanine pigment molecule against flocculation during pigment application. An example is admixture of other agents to the molecule, such as surface active additives to the pigment molecule.
  • the following pigments are illustrative phthalocyanine blue pigments preferably included in the composition according to the invention:
  • the pigment is phthalocyanine blue pigment selected from alpha copper phthalocyanines Pigment Blue 15, Pigment Blue 15:1, Pigment 15:2 and mixtures thereof. Most preferably the pigment is Pigment Blue 15:1.
  • a commercially available example is Cosmenyl Blue A4R from Clariant.
  • the pigment suitable for use in this invention may also be mixtures of any of the above described materials.
  • the oral care composition of the present invention may comprise other pigments in addition to those described above which are included in the composition. It is preferred that the other pigments are green pigments, more preferably green pigments having a hue angle from 120 to 200 degrees.
  • the preferred green pigment is phthalocyanine green pigment, more preferably Phthalocyanine Green CI-74260.
  • the composition comprises a combination of green and blue pigments. The weight ratio of green pigment to blue pigment is greater than 1 :2, preferably greater than 2:3, more preferably from 2:3 to 3:2.
  • the oral care composition of the present invention typically comprises from 0.001 to 1% by weight of the pigment, more preferably from 0.01 to 0.5%, and most preferably from 0.02 to 0.2%, based on total weight of the oral care composition and including all ranges subsumed therein.
  • the total amount of iota and kappa carrageenan to the amount of pigment is present in the composition in a weight ratio from 1 :5 to 100:1 , preferably from 1 :5 to 50:1 and more preferably from 1 :3 to 40:1, and most preferably from 1 :1 to 30:1, including all ratios subsumed therein.
  • the oral care composition of the invention may comprise other polymeric materials in addition to the carrageenans which are included in the composition. Particularly preferred polymeric materials include copolymers of methyl vinyl ether and maleic anhydride, high molecular weight PEGs, high molecular weight cellulose ethers or mixtures thereof.
  • “High molecular weight”, as used herein, means the polymeric material has a molecular weight of at least 100,000 g/mol, preferably at least 200,000 g/mol.
  • Copolymers of methyl vinyl ether and maleic anhydride are especially preferred, which are commercially available under the trade name GANTREZTM.
  • the oral care composition has a pH from 4.0 to 10.0, more preferably from 5.0 to 9.0, and most preferably from 5.5 to 8.0.
  • the pH of oral care composition is measured when 5 parts by weight of the composition is uniformly dispersed and/or dissolved in 20 parts by weight pure water at 25°C.
  • the pH may be measured by manually mixing 5 g oral care composition with 20 mL water for 30 s, then immediately testing the pH with indicator or a pH meter.
  • the oral care composition may comprise other surfactants in addition to the anionic surfactants.
  • Suitable surfactants include non-ionic surfactants, such as polyethoxylated fatty acid sorbitan esters, ethoxylated fatty acids, esters of polyethylene glycol, ethoxylates of fatty acid monoglycerides and diglycerides, and ethylene oxide/propylene oxide block polymers.
  • Other suitable surfactants include amphoteric surfactants, such as betaines or sulphobetaines. Mixtures of any of the above described materials may also be used.
  • the oral care composition is an aqueous composition.
  • the water content is at least 1.5% by weight of the composition, preferably at least 5%, more preferably at least 10%. It is preferable that the water content is from 1.5 to 95% by weight of the composition, more preferably from 5 to 90% and most preferably from 10 to 90%, based on total weight of the composition and including all ranges subsumed therein.
  • the oral care composition of the present invention may comprise a physiologically acceptable carrier.
  • the carrier preferably comprises at least thickener, humectant or a combination thereof.
  • Thickener may be used in this invention and is limited only to the extent that the same may be added to a composition suitable for use in the mouth.
  • Illustrative examples of the types of thickeners that may be used in this invention include, sodium carboxymethyl cellulose (SCMC), hydroxyl ethyl cellulose, methyl cellulose, ethyl cellulose, gum tragacanth, gum arabic, gum karaya, sodium alginate, guar, xanthan gum, starch, modified starch, silica based thickeners including silica aerogels, magnesium aluminum silicate (e.g., Veegum), Carbomers (cross-linked acrylates) and mixtures thereof.
  • SCMC sodium carboxymethyl cellulose
  • hydroxyl ethyl cellulose hydroxyl ethyl cellulose
  • methyl cellulose methyl cellulose
  • ethyl cellulose gum tragacanth
  • gum arabic gum karaya
  • sodium alginate guar
  • xanthan gum and/or sodium carboxymethyl cellulose and/or a Carbomer is/are preferred.
  • a Carbomer those having a weight-average molecular weight of at least 700,000 are desired, and preferably, those having a molecular weight of at least 1,200,000, and most preferably, those having a molecular weight of at least about 2,500,000 are desired. Mixtures of Carbomers may also be used herein.
  • the Carbomer is Synthalen PNC, Synthalen KP or a mixture thereof. It has been described as a high molecular weight and cross-linked polyacrylic acid and identified via CAS number 9063-87-0. These types of materials are available commercially from suppliers like Sigma.
  • the sodium carboxymethyl cellulose (SCMC) used is SCMC 9H. It has been described as a sodium salt of a cellulose derivative with carboxymethyl groups bound to hydroxy groups of glucopyranose backbone monomers and identified via CAS number 9004-32-4. The same is available from suppliers like Alfa Chem.
  • the thickener is xanthan gum.
  • Thickener typically makes up from 0.01 to about 10%, more preferably from 0.1 to 9%, and most preferably, from 0.1 to 5% by weight of the oral care composition, based on total weight of the composition and including all ranges subsumed therein.
  • Suitable humectants are preferably used in the oral care composition of the present invention and they include, for example, glycerin, sorbitol, propylene glycol, dipropylene glycol, diglycerol, triacetin, mineral oil, polyethylene glycol (preferably, PEG-400), alkane diols like butane diol and hexanediol, ethanol, pentylene glycol, or a mixture thereof. Glycerin, polyethylene glycol, sorbitol or mixtures thereof are the preferred humectants.
  • the humectant may be present in the range of from 10 to 90% by weight of the oral care composition. More preferably, the carrier humectant makes up from 25 to 80%, and most preferably, from 30 to 60% by weight of the composition, based on total weight of the composition and including all ranges subsumed therein.
  • the carrier is typically present at a level of from 10 to 90% by weight of the oral care composition, more preferably 25 to 80%, and most preferably from 30 to 70% by weight of the composition, based on total weight of the composition and including all ranges subsumed therein.
  • the oral care composition may comprise a fluoride source.
  • Preferred fluoride source includes sodium fluoride, stannous fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride or mixtures thereof.
  • the fluoride source is stannous fluoride, sodium fluoride, sodium monofluorophosphate or mixtures thereof.
  • Sodium monofluorophosphate is particularly preferred.
  • the fluoride source may be present at a level from 0.01 to 10%, more preferably from 0.03 to 5% and most preferably from 0.1 to 2% by weight of the oral care composition, based on total weight of the composition and including all ranges subsumed therein.
  • the oral care composition may comprise abrasives.
  • Preferred abrasives include silicas, aluminas, calcium carbonates, dicalcium phosphates, calcium pyrophosphates, hydroxyapatites, trimetaphosphates, insoluble hexametaphosphates or mixtures thereof, including agglomerated particulate abrasives. Calcium carbonate and silica are particularly preferred, especially silica.
  • the abrasives may be present in the range of from 0.01 to 60%, more preferably from 0.1 to 30%, and most preferably from 1 to 15% by weight of the oral care composition, based on total weight of the composition and including all ranges subsumed therein.
  • the oral care composition of the present invention may contain a variety of other ingredients which are common in the art to enhance physical properties and performance, in addition to pigments which are included in the composition.
  • These ingredients include antimicrobial agents, anti-inflammatory agents, anti-caries agents, plaque buffers, dyes, vitamins, plant extracts, desensitizing agents, anti-calculus agents, biomolecules, flavors, proteinaceous materials, preservatives, opacifying agents, pH-adjusting agents, sweetening agents, polymeric compounds, buffers and salts to buffer the pH and ionic strength of the compositions, and mixtures thereof.
  • Such ingredients typically and collectively make-up less than 20% by weight of the composition, and preferably, from 0.0 to 15% by weight, and most preferably, from 0.01 to 12% by weight of the composition, including all ranges subsumed therein.
  • the oral care composition of this invention can be used in a method of whitening the teeth of an individual comprising applying the composition to at least one surface of the teeth of the individual.
  • the method is non-therapeutic.
  • the oral care composition of this invention may additionally or alternatively be for used for whitening the teeth of an individual, and/or used in the manufacture of a medicament in whitening teeth of an individual.
  • the use is non-therapeutic.
  • the composition will be packaged.
  • the composition may be packaged in a conventional plastic laminate, metal tube or a single compartment dispenser. The same may be applied to dental surfaces by any physical means, such as a toothbrush, fingertip or by an applicator directly to the sensitive area.
  • the composition In liquid mouthwash form the composition may be packaged in a bottle, sachet or other convenient container.
  • the oral care composition of the invention is preferably a toothpastes or gel.
  • the oral care composition is a toothpaste or gel, the same typically has a viscosity from about 30,000 to 180,000 centipoise, and preferably, from 60,000 to 170,000 centipoise, and most preferably, from 65,000 to 165,000 centipoise, taken at room temperature (25°C) with a Brookfield Viscometer, Spindle No.93/94 and at a speed of 5 rpm for 1 minute.
  • the composition can be effective even when used in an individual’s daily oral hygiene routine.
  • the composition may be brushed onto the teeth and/or be rinsed around the inside of the mouth of the individual.
  • the composition may, for example, be contacted with the teeth for a time period of one second to 20 hours. More preferably from 1 s to 10 hours, more preferably still from 10 s to 1 hour and most preferably from 30 s to 5 minutes.
  • the composition may be used daily, for example for use by an individual once, twice or three times per day.
  • HAP Hydroxyapatite
  • AL L1-L0
  • Aa a1 - aO
  • Ab b1 - bO
  • L1 , a1 and b1 are the color indexes of HAP discs treated by samples
  • L0, aO and bO are the color indexes of blank HAP discs.
  • Sample 1 comprising both iota and kappa carrageenan had higher delta E value compared to other samples, which indicated better deposition of the pigment.
  • a polymer/glycerol solution (DAV diluent) was prepared by combining the ingredients in Table 4, and it was used to mimic the viscosity characteristics of saliva.
  • test sample was mixed with water and DAV diluent at a weight ratio of 1:1:1 to form a toothpaste slurry.
  • the WIO index is an index which has been optimized specifically for the evaluation of whiteness in teeth (as described in Journal of Dentistry, volume 36, Supplement 1 , 2008, pages 2 to 7). Changes in whiteness was calculated based on L*, a*, b* values which were measured using DigiEye (VeriVide, England).
  • Sample 2 comprising both iota and kappa carrageenan showed better tooth whitening efficacy than samples C and D.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition de soin buccal comprenant du iota carraghénane, du kappa carraghénane, un tensioactif anionique, et un pigment ayant un angle de teinte, h, dans le système CIELAB de 220 à 320 degrés, la quantité totale du iota et kappa carraghénane par rapport à la quantité de pigment étant présente dans un rapport pondéral de 1 :5 à 100:1.
PCT/EP2022/071514 2021-08-19 2022-08-01 Composition de soin buccal comprenant du iota carraghénane et du kappa carraghénane WO2023020817A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP22758223.6A EP4387586A1 (fr) 2021-08-19 2022-08-01 Composition de soin buccal comprenant du iota carraghénane et du kappa carraghénane

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CNPCT/CN2021/113547 2021-08-19
CN2021113547 2021-08-19
EP21198273.1 2021-09-22
EP21198273 2021-09-22

Publications (1)

Publication Number Publication Date
WO2023020817A1 true WO2023020817A1 (fr) 2023-02-23

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PCT/EP2022/071514 WO2023020817A1 (fr) 2021-08-19 2022-08-01 Composition de soin buccal comprenant du iota carraghénane et du kappa carraghénane

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EP (1) EP4387586A1 (fr)
WO (1) WO2023020817A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015172344A1 (fr) * 2014-05-15 2015-11-19 The Procter & Gamble Company Compositions de dentifrice présentant une meilleure stabilité de l'ion fluorure
US20150366767A1 (en) * 2012-12-21 2015-12-24 Colgate-Palmolive Company Non-staining toothpaste

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150366767A1 (en) * 2012-12-21 2015-12-24 Colgate-Palmolive Company Non-staining toothpaste
WO2015172344A1 (fr) * 2014-05-15 2015-11-19 The Procter & Gamble Company Compositions de dentifrice présentant une meilleure stabilité de l'ion fluorure

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CAS , no. 9004-32-4
CAS, no. 9063-87-0, pages 57
JOURNAL OF DENTISTRY, vol. 36, 2008, pages 2 - 7

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