WO2019034346A1 - Composition pour le blanchiment des dents - Google Patents

Composition pour le blanchiment des dents Download PDF

Info

Publication number
WO2019034346A1
WO2019034346A1 PCT/EP2018/069218 EP2018069218W WO2019034346A1 WO 2019034346 A1 WO2019034346 A1 WO 2019034346A1 EP 2018069218 W EP2018069218 W EP 2018069218W WO 2019034346 A1 WO2019034346 A1 WO 2019034346A1
Authority
WO
WIPO (PCT)
Prior art keywords
blue
composition
polymeric material
pigment
backbone
Prior art date
Application number
PCT/EP2018/069218
Other languages
English (en)
Inventor
Shahin ALLAHBHASH
Sumana ROYCHOWDHURY
Original Assignee
Unilever N.V.
Unilever Plc
Conopco, Inc., D/B/A Unilever
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever N.V., Unilever Plc, Conopco, Inc., D/B/A Unilever filed Critical Unilever N.V.
Publication of WO2019034346A1 publication Critical patent/WO2019034346A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds
    • A01N57/20—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds containing acyclic or cycloaliphatic radicals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
    • A01N35/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical at least one of the bonds to hetero atoms is to nitrogen
    • A01N35/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical at least one of the bonds to hetero atoms is to nitrogen containing a carbon-to-nitrogen double bond
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A01N43/18—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with sulfur as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/60—1,4-Diazines; Hydrogenated 1,4-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/76—1,3-Oxazoles; Hydrogenated 1,3-oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/733—Alginic acid; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8164—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/58—Metal complex; Coordination compounds

Definitions

  • the present invention relates to an oral care composition for whitening the teeth.
  • the colour of our teeth is influenced by their intrinsic colour and the presence of any extrinsic stains that form thereon. Staining is linked to the adsorption of materials into the pellicle on the surface of the enamel. Factors that influence the degree of extrinsic stains include improper brushing techniques, smoking, dietary intake of coloured foods (e.g. red wine), age and the use of certain cationic agents such as chlorhexidine or salts of tin and iron. People have strong desire for whiter teeth. This desire has led to a growing trend of whitening oral care products which range from toothpastes to mouthwashes and chewing gums.
  • Toothpastes meant for whitening the teeth rely on optimization of abrasive and the chemical components. At the time of brushing, these abrasive particles get temporarily trapped between the toothbrush and the stained surface (of teeth) where they abrade the stains.
  • Chemical components may also be used, usually in conjunction with abrasive particles, and these include calcium chelators, polymers, surfactants, enzymes and oxidising agents.
  • Blue Covarine is a phthalocyanine blue pigment present in the toothpaste named White Now® and there have been attempts to enhance the deposition of this pigment on teeth.
  • Blue dye is a triarylmethane dye which is also used for instant whitening benefits in oral care products.
  • W012/123241 A1 discloses use of poly-sulfonic acid for enhancement of deposition.
  • EP1935395 B1 discloses that upon brushing with the toothpaste described in this publication, a blue pigment (in particular Blue Covarine/ Blue dye) is deposited on the teeth surface, where it alters the optical effects and increases the perception of whiteness.
  • This toothpaste is intended to produce a temporary whitening effect.
  • Deposition of the blue pigment/dye on the teeth is enhanced by a deposition aid such as GANTREZ®, i.e. a co-polymer of maleic anhydride with methyl vinyl ether.
  • Polished hydroxyapatite discs are first placed in deionized water for one hour and the baseline colour measurements made (using, for example, a Minolta chromameter CR300).
  • the discs are then brushed with (i) a suspension of a dye or a pigment in water (e.g. Blue Covarine [BC] at 0.075%/ blue dye at 0.018% by weight) or (ii) a suspension of the same pigment at the same concentration as in (i), together with the deposition aid at approximately 50 times said concentration (e.g. BD at 0.02% and deposition aid at 1 % by weight).
  • the brushing is best performed using a brushing machine. Following rinsing, the colour of the discs is then re-measured and the change in delta b * is recorded for both treatment (i) and treatment (ii). From a comparison of these data, the effect of the deposition aid is readily seen.
  • Some whitening compositions contain a dye instead of pigments.
  • Polymers have been used to aid deposition of some of the dyes and pigments.
  • the preferred dye polymers are of the form, (Polymer chain)-(Y-dye) x , where Y is a link between the dye and the polymer chain and x is the number of dye moieties associated with a given polymer molecule.
  • US2006199955 A discloses modified dyes, such as xanthene dyes, including rhodamines, rhodols and fluoresceins that are substituted with one or two phosphonate groups that are either zwitterionic or a protected form.
  • the dyes which are chemically reactive dyes or dye-conjugates are useful as fluorescent probes, particularly in biological samples.
  • US2017151 158 AA discloses the use of an orally acceptable polyamine compound, e.g., lysine, an anionic polymer and a cationic antibacterial agent to inhibit the association of these components and enhance delivery to the teeth.
  • the anionic polymer is a phosphate/acrylate co-polymer, for example a polymer made up of acrylate monomers and phosphate-bearing monomers.
  • US20080199412 A1 discloses that certain polymers and copolymers comprising phosphonate-containing monomeric groups are effective at inhibiting the formation of chemical stains on teeth. Such polymers and copolymers exhibit improved compatibility with a halogenated diphenylether antibacterial agent, for example in presence of an antibacterial enhancing agent such as PVME/MA in comparison with known polyphosphate-based anti-staining agents.
  • the oral care composition contains a dual functionality polymer which contains one or more of phosphate, phosphonate, bisphosphonate groups in addition to certain other specific functional groups, and a hueing agent which could be a dye or a pigment having CIELAB hue angle "h" of 220 to 320 degrees.
  • an oral care composition comprising: (i) a polymeric material represented by the general formula RY-A-X; and,
  • a teeth whitening agent having hue angle according to the CIELAB system of from 220 to 320 degrees.
  • R H or an alkyl or aryl group
  • Y O, N or S
  • A is backbone of said polymeric material
  • X represents at least one of phosphate, phosphonate or bisphosphonate groups
  • the backbone of the polymeric material is alginic acid, starch, modified starch, cellulose, cellulose ethers, co-polymer of maleic anhydride with methyl vinyl ether, xanthan gum, locust bean gum, carrageenan or pectin
  • a teeth whitening agent having hue angle according to the CIELAB system of from 220 to 320 degrees.
  • R H or an alkyl or aryl group
  • Y O, N or S
  • A is backbone of said polymeric material
  • X represents at least one of phosphate, phosphonate or bisphosphonate groups
  • backbone of the polymeric material is alginic acid, starch, modified starch, cellulose, cellulose ethers, co-polymer of maleic anhydride with methyl vinyl ether, xanthan gum, locust bean gum, carrageenan or pectin
  • backbone of the polymeric material is alginic acid, starch, modified starch, cellulose, cellulose ethers, co-polymer of maleic anhydride with methyl vinyl ether, xanthan gum, locust bean gum, carrageenan or pectin
  • the pH of the composition is measured when 1 part by weight of the composition is uniformly dispersed and/or dissolved in 20 parts by weight pure water at 25 °C.
  • the pH may be measured by manually mixing 1 g composition with 20 ml water for 30 seconds, then immediately testing it with indicator paper or a pH meter.
  • “Substantially free of, as used herein, means comprising less than 1.5%, and preferably less than 1 .0%, and more preferably less than 0.75% and more preferably still less than 0.5%, and even more preferably less than 0.1 % and most preferably from 0.0 to 0.01 % by weight, based on total weight of the composition, including all ranges subsumed therein.
  • Stained teeth could become troublesome, whether the cause for it is intrinsic or an extrinsic factor or an agent like certain beverages and chlorhexidine.
  • Accumulation of stains on teeth poses an aesthetic problem for some individuals. Stains are usually extrinsic in nature and generally represent discoloration of the pellicle or plaque. The exact mechanisms involved in the formation of stains may not be fully understood. It is suggested that pigments produced by chromagenic bacteria, colored products from the chemical transformation of pellicle components and adsorption/retention of dietary constituents contribute to extrinsic stains. The dietary factors which appear to contribute heavily towards staining include coffee, tea, and red wine, as well as smoking. In addition to chlorhexidine, staining is promoted by other cationic
  • antimicrobial agents such as hexetidine or quaternary ammonium compounds.
  • the index proposed by Luo et al (known as WIO) has the same functional form as some of the previously known whiteness indices but the parameters are different and are optimized specifically for the evaluation of whiteness in teeth. It is regarded as most appropriate for assessing any change in whiteness of teeth.
  • R H or an alkyl or aryl group
  • Y O, N or S
  • A backbone of said polymeric material
  • X represents at least one of phosphate, phosphonate or bisphosphonate groups.
  • the "A” part of the polymeric material forms a backbone of the material and it provides structure to it.
  • the "X" and “YR” parts are representative of functional groups present on the backbone.
  • the backbone of the polymeric material is alginic acid, starch, modified starch, cellulose, cellulose ethers, co-polymer of maleic anhydride with methyl vinyl ether, xanthan gum, locust bean gum, carrageenan or pectin.
  • the backbone of the polymeric material comprises one or more OH, OCH3, OC2H5, SH or NH2 groups.
  • the RY OH, OCH 3 , OC2H5, SH or NH2 group.
  • the backbone of the polymeric material does not comprise only free -COOH groups i.e to the exclusion of any other group.
  • the "X" represents at least one of phosphate, phosphonate or bisphosphonate groups.
  • the group or groups could be present in the acid form or alternatively in the form of their salts, including partial salts, preferably with an alkali metal, typically sodium or potassium ions as the counter ions or ammonium ions.
  • the polymeric material comprises covalently bound phosphate, phosphonate or bisphosphonate.
  • Phosphate groups are represented as— O— PO3 2" and phosphonate groups as— PO3 2" .
  • the phosphate, phosphonate or bisphosphonate groups may be introduced by carrying out certain organic reactions with the polymeric material.
  • a polymer containing functionalisable groups (example, carboxylic acid groups) is reacted with molecules containing free hydroxyl or amine groups and phosphonate groups.
  • a suitable polymeric material is synthesized by esterification of Gantrez® with etidronic acid. In this case, the free -COOH groups of Gantrez® react with free - OH groups of etidronic acid. The procedure is as follows.
  • Etidronic acid is dispersed in 40 ml tetrahydrofuran and stirred for 15 minutes.
  • the backbone of the polymeric material contains free -OCH3 groups coming from Gantrez® part as well as phosphonate groups coming from the etidronic acid part.
  • alginic acid can be esterified with etidronic acid.
  • Alginic acid also contains free -COOH groups and -OH groups.
  • the carboxylic acid groups esterify with the free -OH groups of etidronic acid.
  • the backbone of this polymeric material contains free -OH groups coming from alginic acid part as well as phosphonate groups coming from the etidronic acid part.
  • a suitable polymeric material is synthesized by amination of Gantrez® with alendronic acid. This acid contains free -IMH2 groups and phosphonate groups. The reaction can be carried out as follows:
  • Alendronic acid is mixed with Gantrez® in an aqueous medium in presence of 1 -Ethyl- 3-(3-dimethylaminopropyl) carbodiimide (as coupling agent) and N-hydroxysuccinimide (as a catalyst).
  • Coupling reaction between the free amine group in alendronic acid and the carboxylic acid group in Gantrez is carried out at 0 °C for two hours and further at room temperature for another six hours.
  • the final solution is centrifuged and the precipitate is dried under vacuum for 24 hours at 40 °C.
  • the backbone of the polymeric material contains free -OCH3 groups coming from Gantrez® part as well as phosphonate groups coming from the alendronic acid part.
  • alginic acid can be aminated with alendronic acid.
  • Alginic acid also contains free -COOH groups and -OH groups.
  • the carboxylic acid groups can aminate with the free -IMH2 groups of alendronic acid leading to amide linkages between the two.
  • the backbone of this polymeric material contains free -OH groups coming from alginic acid part as well as phosphonate groups coming from the alendronic acid part.
  • the polymeric material itself is commercially available.
  • An example thereof is Structure XL® from Akzo Nobel. It is Hydroxypropyl Starch Phosphate.
  • compositions of the invention comprise 0.1 to 10 wt% polymeric material and more preferably 0.5 to 5 wt% by weight of the composition.
  • backbone of the polymeric material is a high molecular weight.
  • high molecular weight material generally means that the backbone of the polymeric material has molecular weight of at least 50,000, more preferably at least 500,000 g/mol.
  • a suitable method to determine the molecular weight of such polymeric materials is gel permeation chromatography against a polyethylene glycol standard.
  • the hueing agent comprised in the compositions of the invention is a dye or a pigment. Alternatively, it is combination of the two. Whitening effect is achieved when the pigment or dye deposits on teeth which leads to reflection of some amount of incident light. The net result is that teeth appear whiter than usual.
  • the hue angle of the hueing agent is from 220 to 320 degrees, more preferably between 250 and 290 degrees.
  • a pigment is generally insoluble in the relevant medium under given conditions. This is in contrast to dyes which are soluble in the medium, which in most cases is water.
  • a preferred single pigment is blue or violet
  • the effect may be achieved by mixing pigments outside of this hue range; for example, such a hue angle within the disclosed range may also be obtained by mixing a red and green-blue pigment to yield a blue or violet shaded pigment.
  • maximum absorption of the pigment is at 400 to 700 nm, which is termed Amax. More preferably, the A ma x ranges from 500 to 580 nm, more preferably from 520 to 560 nm.
  • the Absorbance of the pigment at its A ma x is at least 0.01 , more preferably at least 0.2. Absorption is measured using 1 % aqueous solutions in 1 cm cells, optionally in the presence of 0.1 % by weight linear alkylbenzene sulphonate.
  • the hueing agent is a pigment
  • the pigment is a blue pigment. More preferably it is selected from alpha copper phthalocyanines which designated as C.I. Pigment Blue 15, more preferably Pigment Blue 15:1 , 15:2, 15:3, 15:4, 15:5 or 15:6, most preferably 15:1.
  • a particularly preferred pigment is Blue Covarine.
  • a commercially available is Covarine Blue W 6795, ex Sensient Cosmetic Technologies/LCW. Mixtures of any of the above described materials may also, alternatively, be used.
  • blue pigments examples include inorganic blue pigments such as iron blue (C.I. 77510) and ultramarine blue (C.I. 77007).
  • a preferred class of blue pigments for use in the invention are organic blue pigments such as phthalocyanine blue pigments.
  • Phthalocyanines are organometallic compounds containing four symmetrically arranged isoindole rings connected in a 16- membered ring linking with alternate carbon and nitrogen atoms. Most phthalocyanines contain a central, coordinated metal ion such as copper. Copper phthalocyanines have the basic structure:
  • Phthalocyanine blue pigments exhibit more than one crystal modification, which differ in terms of coloristics. Methods have been developed to phase-stabilise the
  • phthalocyanine pigment molecule in order to prevent conversion to a different crystal modification.
  • An example is minor chemical modification of the molecule, for instance partial chlorination.
  • Methods have also been developed to stabilise the phthalocyanine pigment molecule against flocculation during pigment application.
  • An example is admixture of other agents to the molecule, such as surface active additives to the pigment molecule.
  • the following pigments listed in Table 1 are illustrative
  • phthalocyanine blue pigments preferably comprised in the composition according to the invention:
  • compositions of the invention comprise a dye as a hueing agent.
  • the hue angle may be achieved by incorporation of a mixture of dye moieties having hue angles outside of the preferred range, for example by mixing red and green-blue dye moieties in a given composition.
  • dyes are soluble in the medium in which they are applied. It is preferred that the dye is water soluble as this property enhances its formulation and delivery to the tooth surface.
  • Water solubility means at 25 °C the dye has an aqueous solubility of at least 10 g/L, most preferably at least 100 g/L at 25 °C. (where the solubility is determined in un-buffered distilled water). The dye tends to stay in solution in the mouth, where the temperature can be somewhat higher, rising to up to 37 °C. It should be understood that water solubility of the dye polymer is at its natural pH, although it also beneficial that the dye polymer is water soluble at pH 8 and/or pH 9 in view of the alkaline environment typically found inside the mouth of human beings.
  • the dye is selected from the following chromophore classes:
  • Some examples of preferred dyes are acid violet 1 , acid violet 3, acid violet 6, acid violet 1 1 , acid violet 13, acid violet 14, acid violet 19, acid violet 20, acid violet 36, acid violet 36:1 , acid violet 41 , acid violet 42, acid violet 43, acid violet 50, acid violet 51 , acid violet 63, acid violet 48, acid blue 25, acid blue 40, acid blue 40:1 , acid blue 41 , acid blue 45, acid blue 47, acid blue 49, acid blue 51 , acid blue 53, acid blue 56, acid blue 61 , acid blue 61 :1 , acid blue 62, acid blue 69, acid blue 78, acid blue 81 :1 , acid blue 92, acid blue 96, acid blue 108, acid blue 1 1 1 , acid blue 215, acid blue 230, acid blue 277, acid blue 344, acid blue 1 17, acid blue 124, acid blue 129, acid blue 129:1 , acid blue 138, acid blue 145, direct violet 99, direct violet 5, direct violet 72, direct violet 16, direct violet 78, direct
  • oral care compositions of the invention It is preferred that the oral care composition is a toothpaste. Alternatively, the oral care composition is a mouthwash. Other known forms include toothpowder, chewing gums and lozenges, strips and gels.
  • the oral care composition according to the invention is a toothpaste
  • the toothpaste comprises at least one of calcium-based abrasive or silica- based abrasive.
  • Toothpastes are also known as dentifrices.
  • dentifrice generally denotes formulations which are used to clean the surfaces of the oral cavity.
  • the dentifrice is an oral composition that is not intentionally swallowed for purposes of systemic
  • the dentifrice is used in conjunction with a cleaning implement such as a toothbrush, usually by applying it to the bristles of the toothbrush and then brushing the accessible surfaces of the oral cavity.
  • a cleaning implement such as a toothbrush
  • the dentifrice is in the form of a paste or a gel (or a combination thereof).
  • An oral care composition according to the invention will usually contain a liquid continuous phase in an amount of from 40 to 99% by weight based on the total weight of the dentifrice.
  • a liquid continuous phase will typically comprise a mixture of water and polyhydric alcohol in various relative amounts, with the amount of water generally ranging from 10 to 45% by weight (based on the total weight of the dentifrice) and the amount of polyhydric alcohol generally ranging from 30 to 70% by weight (based on the total weight of the dentifrice).
  • Humectants are generally included in toothpastes for a soft, supple mouth feel.
  • Humectants also reduce thte tendency of toothpastes to lose moisture.
  • Preferred toothpaste compositions contain 3.5 to 40 wt% humectants. Further preferred compositions have 10 to 40 wt%, more particularly 10 to 20 wt% humectants.
  • a particularly preferred humectant is sorbitol, generally available as 70% aqueous solution.
  • Other preferred humectants include glycerine, maltitol and xylitol. More preferred toothpastes contain glycerine and sorbitol for a lubricated mouth feel, but their cumulative levels should not exceed the disclosed upper limit. Lower humectant content provides an effective way to reduce the cost of the product.
  • An oral care composition according to the invention will generally contain further ingredients to enhance performance and/or consumer acceptability such as abrasive cleaning agent, binder or thickening agent, and surfactant.
  • a dentifrice will usually comprise an abrasive cleaning agent in an amount of from 3 to 75% by weight based on the total weight of the dentifrice.
  • Suitable abrasive cleaning agents include silica xerogels, hydrogels and aerogels and precipitated particulate silicas; calcium carbonate, dicalcium phosphate, tricalcium phosphate, calcined alumina, sodium and potassium metaphosphate, sodium and potassium pyrophosphates, sodium trimetaphosphate, sodium hexametaphosphate, particulate hydroxyapatite and mixtures thereof.
  • abrasives examples include abrasive amorphous silica particles which have a weight mean particle size (d50) ranging from 3 to 15 microns.
  • Preferred abrasive amorphous silica particles for use in the composition of the invention have a weight mean particle size in the range 3 to 6 microns.
  • the abrasive amorphous silica particles employed are precipitated silica.
  • Suitable precipitated silicas for use as abrasive amorphous silica particles in the invention are commercially available and include those marketed by PQ Corporation under the trade names SORBOSIL® AC 43, AC77, AC35 and SORBOSIL® AC
  • the level of abrasive amorphous silica particles generally ranges from 0.05 to 5%, preferably from 0.1 to 3%, more preferably from 0.2 to 0.8%, by total weight abrasive amorphous silica particles (as defined above) based on the total weight of the composition.
  • compositions of the invention comprise calcium-based abrasive.
  • a particularly preferred abrasive is fine ground natural chalk (FGNC). It is obtained from limestone or marble.
  • FGNC may also be modified chemically or physically by coating during or after milling by heat treatment. Typical coating materials include magnesium stearate and oleate.
  • the morphology of FGNC may also be modified during the milling process by using different milling techniques, for example, ball milling, air-classifier milling or spiral jet milling.
  • FGNC can be used as the sole calcium containing abrasive. However, FGNC can also be used with other calcium containing abrasives to balance the abrasion.
  • DCP dicalcium phosphate
  • PCC precipitated calcium carbonate
  • compositions of the invention preferably comprise a binder or thickening agent in an amount of from 0.5 to 10% by weight based on the total weight of the dentifrice.
  • Suitable binders or thickening agents include carboxyvinyl polymers (such as polyacrylic acids cross-linked with polyallyl sucrose or polyallyl
  • compositions of the invention preferably comprise a surfactant in an amount of from 0.2 to 10% by weight based on the total weight of the dentifrice.
  • Suitable surfactants include anionic surfactants, such as the sodium, magnesium, ammonium or ethanolamine salts of C8 to C18 alkyl sulphates (for example sodium lauryl sulphate), C8 to C18 alkyl sulphosuccinates (for example dioctyl sodium sulphosuccinate), C8 to C18 alkyl sulphoacetates (such as sodium lauryl sulphoacetate), C8 to C18 alkyl sarcosinates (such as sodium lauryl sarcosinate), C8 to C18 alkyl phosphates (which can optionally comprise up to 10 ethylene oxide and/or propylene oxide units) and sulphated monoglycerides.
  • anionic surfactants such as the sodium, magnesium, ammonium or ethanolamine salts of C8 to C18 alkyl sulphates (for example sodium lauryl sulphate), C8 to C18 alkyl sulphosuccinates (
  • Suitable surfactants include nonionic surfactants, such as optionally polyethoxylated fatty acid sorbitan esters, ethoxylated fatty acids, esters of polyethylene glycol, ethoxylates of fatty acid monoglycerides and diglycerides, and ethylene oxide/propylene oxide block polymers.
  • suitable surfactants include amphoteric surfactants, such as betaines or sulphobetaines. Mixtures of any of the above described materials may also be used. Smectite clay
  • oral care compositions of the invention include a smectite clay which is in addition to the clay present by way of the bipolar antimicrobial material.
  • Smectites constitute a group in the class of natural aluminosilicate minerals known as
  • Preferred smectite clay is selected from
  • montmorillonites bentonites, hectorites and derivatives thereof
  • purified aluminium magnesium silicates variant grades are commercially available as VEEGUM (R) from R. T. Vanderbilt Company
  • purified sodium magnesium silicates commercially available as LAPONITE (R) in various grades
  • organically modified smectites including tetra alkyl and/or trialkyl ammonium smectites organically modified montmorillonite clays
  • Aluminium magnesium silicate clays are particularly preferred.
  • An example is VEEGUM (R) HV. The clay tends to swell when exposed to water.
  • Preferred toothpaste compositions contain 0.2 to 3 wt percent clay. More preferred compositions include 0.5 to 1 wt percent clay.
  • the smectite clay not only plays a role in sensory profile as is believed, but it also plays a role in thickening the composition, as the reduced content of thickening silica otherwise leads to a product with lower viscosity.
  • compositions of the invention further preferably comprise a zinc salt, preferably zinc sulphate or zinc chloride, more preferably zinc sulphate heptahydrate.
  • a zinc salt preferably zinc sulphate or zinc chloride, more preferably zinc sulphate heptahydrate.
  • the level of zinc salt is from 0.05 to 1.0 wt% of the total composition more preferably from 0.1 to 0.5 wt%.
  • Compositions of the invention may comprise a preservative, a preferred preservative is sodium benzoate.
  • the level of preservative is from 0.1 to 1 wt% of the total composition. It is preferred that pH of the composition at 20 °C is from 4 to 10, more preferably 7 to 9.
  • mouthwash generally denotes liquid formulations which are used to rinse the surfaces of the oral cavity and provide the user with a sensation of oral cleanliness and refreshment.
  • the mouthwash is an oral composition that is not intentionally swallowed for purposes of systemic administration of therapeutic agents, but is applied to the oral cavity, used to treat the oral cavity and then expectorated.
  • a mouthwash composition will usually contain an aqueous continuous phase.
  • the amount of water generally ranges from 70 to 99% by weight based on the total weight of the mouthwash.
  • a mouthwash composition according to the invention will generally contain further ingredients to enhance performance and/or consumer acceptability, such as the humectants and surfactants mentioned above for dentifrices.
  • the amount of humectant generally ranges from 5 to 20% by weight based on the total weight of the mouthwash and the amount of surfactant generally ranges from 0.1 to 5% by weight based on the total weight of the mouthwash.
  • compositions of the present invention (such as in particular dentifrices or
  • mouthwashes may also contain further optional ingredients customary in the art such as fluoride ion sources, anticalculus agents, buffers, flavouring agents, sweetening agents, colouring agents, opacifying agents, preservatives, antisensitivity agents and antimicrobial agents.
  • fluoride ion sources such as fluoride ion sources, anticalculus agents, buffers, flavouring agents, sweetening agents, colouring agents, opacifying agents, preservatives, antisensitivity agents and antimicrobial agents.
  • Use of the composition in the context of this invention typically involves application of the composition to the oral cavity, for a recommended time, before being expectorated. The preferred application time being from 10 to 60 seconds.
  • an oral care composition comprising:
  • a teeth whitening agent having hue angle according to the CIELAB system of from 220 to 320 degrees.
  • R H or an alkyl or aryl group
  • Y O, N or S
  • A is backbone of said polymeric material
  • X represents at least one of phosphate, phosphonate or bisphosphonate groups
  • the backbone of the polymeric material is alginic acid, starch, modified starch, cellulose, cellulose ethers, co-polymer of maleic anhydride with methyl vinyl ether, xanthan gum, locust bean gum, carrageenan or pectin.
  • the method of whitening the teeth may be performed in a dentist's office or clinic under ordinary or supervised conditions. Alternatively, and more preferably the method is performed by an informed user at home or in other words, without any medical supervision when the method is non-therapeutic.
  • the composition and method of the invention is useful to whiten teeth. This means that the composition is useful to preserve the white appearance of teeth or to restore the appearance periodically.
  • the composition and the method is useful to lighten the teeth which are discoloured due to extrinsic or intrinsic stains (e.g., tobacco, coffee, tea and/or food or wine stains), fluorosis, developmental disturbances, bacteria, genetics, tetracycline antibiotics, trauma, blood decomposition, pigments present during development of teeth.
  • extrinsic or intrinsic stains e.g., tobacco, coffee, tea and/or food or wine stains
  • fluorosis e.g., tobacco, coffee, tea and/or food or wine stains
  • developmental disturbances e.g., bacteria, genetics, tetracycline antibiotics, trauma, blood decomposition, pigments present during development of teeth.
  • the method is non-therapeutic.
  • a method is a cosmetic method.
  • a therapeutic treatment starts from a pathological state, whereas a non- therapeutic treatment starts from a normal, healthy state.
  • Application of such a method to a person is to improve his bodily appearance (cosmetic treatment).
  • Treatment by therapy is defined as any treatment which is designed to cure, alleviate, remove or lessen the symptoms of, or prevent or reduce the possibility of contracting any disorder or malfunction of the human body, in this case it is teeth.
  • the use is for non-therapeutic purpose.
  • the use is for therapeutic purpose.
  • the part of the description related to the method of the invention is also applicable mutatis mutandis to this aspect of the invention.
  • delta b * A convenient measure of the whiteness of teeth is delta b * which is measured using a chromameter. Negative values of delta b * indicate a colour shift from yellow to blue which has been shown to be one of the primary drivers of whiteness as perceived by consumers.
  • Comparison of 2 against 3 demonstrates the effect of having a polymeric material with backbone of alginic acid.
  • Comparison of serial no. 6 against 10 shows the surprising effect of the invention as compared to its closest comparative data in which an admixture of Gantrez® and etidronic acid is used.
  • serial no. 7 shows the surprising effect of the invention as compared to its closes comparative data in which an admixture of alginic acid and etidronic acid shows significantly lesser b * value.
  • Serial nos. 1 1 and 12 show the effect of the invention with a commercially available material which contains phosphate groups and hydroxypropyl groups. The data also shows dose dependency. The data of serial no.13 indicates that when the polymeric material contains only free - COOH groups (and phosphonate groups), the technical effect is not observed.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition de soins bucco-dentaires comprenant : (i) un matériau polymère représenté par la formule générale RY-A-X; et, (ii) un agent de blanchiment des dents ayant un angle de teinte selon le système CIELAB de 220 à 320 degrés. Où R = H ou un groupe alkyle ou aryle, Y = O, N ou S; A est un squelette dudit matériau polymère, et X représente au moins un des groupes phosphate, phosphonate ou bisphosphonate; et le squelette du matériau polymère étant l'acide alginique, l'amidon, l'amidon modifié, la cellulose, les éthers de cellulose, le copolymère d'anhydride maléique avec l'éther méthylvinylique, la gomme xanthane, la gomme de caroube, le carraghénane ou la pectine.
PCT/EP2018/069218 2017-08-17 2018-07-16 Composition pour le blanchiment des dents WO2019034346A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17186564.5 2017-08-17
EP17186564 2017-08-17

Publications (1)

Publication Number Publication Date
WO2019034346A1 true WO2019034346A1 (fr) 2019-02-21

Family

ID=59699499

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2018/069218 WO2019034346A1 (fr) 2017-08-17 2018-07-16 Composition pour le blanchiment des dents

Country Status (1)

Country Link
WO (1) WO2019034346A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114430678A (zh) * 2019-10-04 2022-05-03 联合利华知识产权控股有限公司 包含六偏磷酸盐和颜料的口腔护理组合物

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030206874A1 (en) * 1996-11-21 2003-11-06 The Proctor & Gamble Company Promoting whole body health
US20050271602A1 (en) * 2004-06-02 2005-12-08 Nebojsa Milanovich Method for inhibiting chemical staining of teeth
US20060199955A1 (en) 2004-08-13 2006-09-07 Epoch Biosciences, Inc. Phosphonylated fluorescent dyes and conjugates
US20080199412A1 (en) 2004-06-02 2008-08-21 Colgate-Palmolive Company Anti-staining antibacterial dentifrice
US20120093905A1 (en) 2009-06-26 2012-04-19 Stephen Norman Batchelor Oral care compositions comprising a polymeric dye
WO2012123241A2 (fr) 2011-03-11 2012-09-20 Unilever Plc Composition de soins buccaux
EP1935395B1 (fr) 2006-12-20 2013-06-05 Unilever PLC Compositions de protection orale
WO2014117904A2 (fr) * 2013-02-01 2014-08-07 Unilever Plc Compositions de soin buccal
WO2015094335A1 (fr) * 2013-12-20 2015-06-25 Colgate-Palmolive Company Compositions et méthodes de soin buccal
WO2016064882A1 (fr) * 2014-10-20 2016-04-28 The Children's Medical Center Corporation Systèmes d'administration de médicaments par voie orale, réversible et prolongée
WO2016099524A1 (fr) * 2014-12-19 2016-06-23 Colgate-Palmolive Company Produit d'hygiène buccale pour le blanchiment des dents
US20170151158A1 (en) 2015-12-01 2017-06-01 Colgate-Palmolive Company Oral Care Compositions

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030206874A1 (en) * 1996-11-21 2003-11-06 The Proctor & Gamble Company Promoting whole body health
US20050271602A1 (en) * 2004-06-02 2005-12-08 Nebojsa Milanovich Method for inhibiting chemical staining of teeth
US20080199412A1 (en) 2004-06-02 2008-08-21 Colgate-Palmolive Company Anti-staining antibacterial dentifrice
US20060199955A1 (en) 2004-08-13 2006-09-07 Epoch Biosciences, Inc. Phosphonylated fluorescent dyes and conjugates
EP1935395B1 (fr) 2006-12-20 2013-06-05 Unilever PLC Compositions de protection orale
US20120093905A1 (en) 2009-06-26 2012-04-19 Stephen Norman Batchelor Oral care compositions comprising a polymeric dye
WO2012123241A2 (fr) 2011-03-11 2012-09-20 Unilever Plc Composition de soins buccaux
WO2014117904A2 (fr) * 2013-02-01 2014-08-07 Unilever Plc Compositions de soin buccal
WO2015094335A1 (fr) * 2013-12-20 2015-06-25 Colgate-Palmolive Company Compositions et méthodes de soin buccal
WO2016064882A1 (fr) * 2014-10-20 2016-04-28 The Children's Medical Center Corporation Systèmes d'administration de médicaments par voie orale, réversible et prolongée
WO2016099524A1 (fr) * 2014-12-19 2016-06-23 Colgate-Palmolive Company Produit d'hygiène buccale pour le blanchiment des dents
US20170151158A1 (en) 2015-12-01 2017-06-01 Colgate-Palmolive Company Oral Care Compositions

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
H. ZOLLINGER: "Colour Chemistry", WILEY-VCH
LUO ET AL.: "proposed a modified version of CIE Whiteness Index in Measuring The Whiteness Of Human Teeth", COLOR RESEARCH AND APPLICATION, vol. 18, 1993, pages 349 - 352

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114430678A (zh) * 2019-10-04 2022-05-03 联合利华知识产权控股有限公司 包含六偏磷酸盐和颜料的口腔护理组合物
CN114430678B (zh) * 2019-10-04 2024-03-26 联合利华知识产权控股有限公司 包含六偏磷酸盐和颜料的口腔护理组合物

Similar Documents

Publication Publication Date Title
EP2600938B1 (fr) Compositions de protection orale
KR101377083B1 (ko) 실리카
US4456585A (en) Visually clear pigment-colored dentifrice composition
CA1086228A (fr) Pate dentifrice formee essentiellement d'un sel de zinc et d'un abrasif dur
CN106999392A (zh) 牙齿美白口腔护理产品
AU2013408265A1 (en) Oral care compositions and methods
US20200368005A1 (en) Polyelectrolyte dental coatings
GB2110083A (en) Visually clear coloured dentifrice
WO2014117904A2 (fr) Compositions de soin buccal
WO1993024103A1 (fr) Composition pour l'hygiene buccale
EP2648680B1 (fr) Compositions pour application orale comprenant des pigments nacrés
WO2019034346A1 (fr) Composition pour le blanchiment des dents
EP3774944B1 (fr) Nouveau polymère, composition, procédé et kit de blanchiment des dents
ZA200602359B (en) A dentifrice composition comprising a soluble calcium sequestering agent
EP3651722B1 (fr) Matériau composite pour le blanchiment des dents et composition le comprenant
GB2138677A (en) Visually clear dentifrice containing calcium ions
CA3018963A1 (fr) Colles dentaires polyelectrolytiques pour le blanchiment des dents et de composants dentaires
WO2021047900A1 (fr) Composition de soin buccal
EP4387586A1 (fr) Composition de soin buccal comprenant du iota carraghénane et du kappa carraghénane
EP4387581A1 (fr) Composition de soin buccodentaire comprenant de la gomme de fenugrec
WO2022106186A1 (fr) Composition de soin buccal pour des avantages de blanchiment
WO2023110213A1 (fr) Composition de soins bucco-dentaires comprenant des phytates et un pigment
JPS6145606B2 (fr)
EP3975984A1 (fr) Composition de soin buccal antitaches
EP3773431A1 (fr) Composition de soin bucco-dentaire

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18743446

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18743446

Country of ref document: EP

Kind code of ref document: A1