WO2023015801A1

WO2023015801A1 - Freeze-drying device for drug injection preparation

Info

Publication number: WO2023015801A1
Application number: PCT/CN2021/138458
Authority: WO
Inventors: 李一青; 陈兴禹
Original assignee: 海南海灵化学制药有限公司
Priority date: 2021-08-10
Filing date: 2021-12-15
Publication date: 2023-02-16
Also published as: CN113532031B; CN113532031A

Abstract

A freeze-drying device for a drug injection preparation, comprising a freeze-drying apparatus body. The freeze-drying apparatus body comprises a vacuum tank (1). A storage tank is arranged below the vacuum tank (1). A powdery injection is contained in the storage tank. The storage tank is communicated with the bottom of the vacuum tank (1) by means of a conveyor (2). A spiral plate (3), a first rotating shaft (4), a material guide plate (5), a material collection ring (6), and a first motor (7) are provided in the vacuum tank (1). The first motor (7) is connected to the first rotating shaft (4). The spiral plate (3) is disposed on the first rotating shaft (4). A lower end of the spiral plate (3) is used for scraping out an injection on the upper layer. The material guide plate (5) is provided on an upper end of the spiral plate (3). The material guide plate (5) is used for guiding the injection into the material collection ring (6). The bottom of the material collection ring (6) is communicated with a first discharge pipe (8). Lifting/lowering rods (9) are arranged on two sides above the spiral plate (3), and are connected to a screw rod (10). The screw rod (10) is slidably connected to sliding strips (11). The sliding strips (11) on two sides are connected to each other by means of a first scraper (12). The sliding strips (11) are provided with a connecting rod (13). The other end of the connecting rod (13) is slidably connected to a rail (14) fixed in the vacuum tank (1). The connecting rod (13) drives the sliding strips (11) to move up and down and move reciprocatingly along a threaded rod when the connecting rod (13) slides along the rail (14), so that the first scraper (12) drives the injection to move upwards along the spiral plate (3). The device can transfer the dry injection on the upper layer to the spiral plate (3) for further drying to promote drying of the injection on the lower layer, and continuous drying and material discharge are realized, so that the drying efficiency is high.

Description

Freeze-drying equipment for drug injection preparations

technical field

The invention relates to the technical field of freeze-drying equipment, in particular to a freeze-drying equipment for drug injection preparations.

Background technique

Freeze drying is also called sublimation drying. The drying method is to freeze the water-containing material below the freezing point, turn the water into ice, and then turn the ice into vapor under a relatively high vacuum to remove it. The material can be frozen in the freezer first, and then dried. It can also be frozen directly in the freeze-drying equipment through rapid vacuuming. The water vapor generated by sublimation is removed by the condenser. The heat of vaporization required in the sublimation process is generally supplied by thermal radiation.

The Chinese patent with the patent number CN201721788342.X discloses a vacuum freeze dryer for producing ribavirin, which includes a vacuum freezing tank and a vacuum drying tank. The top of the vacuum freezing tank is provided with a feed port, and the side wall is connected with Refrigeration unit and vacuum pump unit, the vacuum pump unit is connected to the vacuum freezing tank through the vacuum pumping unit, the medicine liquid is vacuum frozen under the action of the refrigeration unit and the vacuum pump unit, and then dried under the action of the heating unit to obtain the medicine.

In the prior art, when the injection is freeze-dried, a certain amount of the injection is usually put into the vacuum tank of the freeze-drying equipment for drying, and after all the injections of this part meet the drying requirements, they are all taken out, and then re-put into the injection for drying. Therefore can not work continuously, and when drying, the injection that is positioned at the upper layer first meets the drying requirement, and the injection that meets the drying requirement is still positioned at the upper layer and covers the injection of the lower layer, which affects the drying efficiency.

Contents of the invention

In view of the above-mentioned prior art, the present invention is to provide a freeze-drying equipment for drug injection preparations, which can transfer the dried injections in the upper layer to the spiral plate for further drying, promote the drying of the injections in the lower layer, and can continuously dry and discharge materials, with high drying efficiency .

Technical scheme of the present invention is realized like this:

A freeze-drying device for drug injection preparations, comprising a freeze-drying device body, the freeze-drying device body includes a vacuum tank, a storage tank is provided below the vacuum tank, and powdered injections are contained in the storage tank. The storage tank communicates with the bottom of the vacuum tank through a conveyor, and the vacuum tank is provided with a spiral plate, a first rotating shaft, a material guide plate, a collection ring and a first motor, and the first motor is connected to the first rotating shaft , the first rotating shaft is provided with the spiral plate, the lower end of the spiral plate is used to scrape the upper injection, and the upper end is provided with the material guide plate, which is used to guide the injection into the collection In the material ring, the bottom of the material collecting ring communicates with the first discharge pipe, and the two sides above the spiral plate are provided with lifting rods, the lifting rods are connected with the screw rod, and the screw rod is slidably connected with a slide bar. The slide bars on both sides are connected to each other through the first scraper, the slide bar is provided with a connecting rod, and the other end of the connecting rod is slidingly connected with the track fixed in the vacuum tank; the connecting rod extends along the When the track slides, it drives the slide bar to move up and down and to reciprocate along the spiral rod, so that the first scraper drives the injection to move upward along the spiral plate.

Further, the track includes several track units sequentially connected to form a closed loop, and the track unit includes a first curved part, a second curved part, a third curved part and a fourth curved part connected in sequence, and the first curved part A bent portion is bent upward, the second bent portion is bent inward, the third bent portion is bent downward, and the fourth bent portion is bent outward.

Further, the connecting rod is V-shaped, one end of the connecting rod is provided with a slider sliding in the track, and the other end is connected to the two sliding bars.

Further, the conveyor is a screw conveyor, and the conveyor is used to transport the injection into the vacuum tank, and the storage tank is tightly connected with the vacuum tank through threads.

Further, the inner ring of the collecting ring is provided with a baffle, the outlet of the material guide plate extends into the collecting ring, the bottom of the collecting ring is provided with an opening, and the opening passes through the first A discharge pipe is connected, and the first discharge pipe is provided with a control valve.

Further, the control valve includes a valve seat, a valve core, a rotating shaft and a second scraper, the valve seat is provided with a cylindrical cavity, and the side wall of the cylindrical cavity is provided with a feed port and a discharge port. mouth, the feed port is located on the opposite side of the discharge port, the valve core is a positive prism, the edge of the valve core fits the inner wall of the cylindrical cavity, and the shaft and the valve core connected, the rotating shaft rotates under the drive of the second motor, the discharge port is provided with the second scraper, and the second scraper is elastic and adheres to the side of the valve core.

Further, the outer surface of the valve core is provided with a rubber layer.

Further, the first discharge pipe communicates with the buffer tank.

The beneficial effects of the present invention are:

The injection on the upper layer in the vacuum tank dries earlier than the injection on the lower layer. When the spiral plate rotates, it scoops up the injection on the upper layer and makes it move upward along the spiral plate. The injection on the upper layer enters the vacuum tank first, and the injection on the upper layer is close to the drying requirement first. Even if the injection on the upper layer is removed, it is beneficial to the drying of the injection on the lower layer, which improves the drying efficiency and can be discharged continuously. When the injection is on a spiral plate, it can also be freeze-dried. The injection on the spiral plate is dispersed, which improves the evaporation area and improves the drying efficiency. When the connecting rod moves along the track, it drives the slide bar to move vertically upward, downward along the spiral plate, vertically downward, and upward along the spiral plate, thereby continuously moving the injection on the spiral plate upward. The upward moving injection reaches the top of the spiral plate and falls into the material guide plate, then the material enters the collection ring along the material guide plate, enters the first discharge pipe from the collection ring, and finally discharges.

Description of drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following will briefly introduce the drawings that need to be used in the description of the embodiments. Obviously, the drawings in the following description are only preferred embodiments of the present invention. For those skilled in the art, other drawings can also be obtained based on these drawings without any creative effort.

Fig. 1 is the sectional view of the freeze-drying equipment that a kind of drug injection preparation of the present invention is used;

Fig. 2 is a top view of a spiral plate and a track of a freeze-drying device for drug injection preparations according to the present invention;

Fig. 3 is the front view of the track of the freeze-drying equipment used for a kind of drug injection preparation of the present invention;

Fig. 4 is the sectional view of the control valve of the freeze-drying equipment that a kind of drug injection preparation of the present invention is used;

In the figure, 1 vacuum tank, 2 conveyor, 3 spiral plate, 4 first rotating shaft, 5 material guide plate, 6 collecting ring, 7 first motor, 8 first discharge pipe, 9 lifting rod, 10 screw rod, 11 slide bar, 12 first scraper, 13 connecting rod, 14 track, 15 first curved part, 16 second curved part, 17 third curved part, 18 fourth curved part, 19 slider, 20 baffle plate, 21 Opening, 22 control valve, 23 valve seat, 24 spool, 25 rotating shaft, 26 second scraper, 27 cylindrical cavity, 28 second motor, 30 buffer tank.

Detailed ways

In order to better understand the technical content of the present invention, specific embodiments are provided below, and the present invention is further described in conjunction with the accompanying drawings.

Referring to Figures 1 to 4, a freeze-drying device for drug injection preparations includes a freeze-drying device body, the freeze-drying device body includes a vacuum tank 1, and a storage tank is provided below the vacuum tank 1, and the storage tank contains There is a powdered injection, and the storage tank communicates with the bottom of the vacuum tank 1 through the conveyor 2. The vacuum tank 1 is equipped with a spiral plate 3, a first rotating shaft 4, a material guide plate 5, a collection ring 6 and a second A motor 7, the first motor 7 is connected to the first rotating shaft 4, the first rotating shaft 4 is provided with the spiral plate 3, the lower end of the spiral plate 3 is used to scrape out the upper injection, and the upper end The material guide plate 5 is provided, and the material guide plate 5 is used to introduce the injection into the collection ring 6, the bottom of the collection ring 6 communicates with the first discharge pipe 8, and the top of the spiral plate 3 Lifting rods 9 are provided on both sides of the upper and lower sides, and the lifting rods 9 are connected with the screw rod 10, and the screw rod 10 is slidably connected with slide bars 11, and the slide bars 11 on both sides are connected to each other through the first scraper 12, so that The sliding bar 11 is provided with a connecting rod 13, and the other end of the connecting rod 13 is slidingly connected with the track 14 fixed in the vacuum tank 1; when the connecting rod 13 slides along the track 14, it drives the sliding bar 11 up and down Movement and reciprocating movement along the spiral rod, so that the first scraper 12 drives the injection to move upward along the spiral plate 3 .

The powdered injection is prepacked in the storage tank, and the storage tank is communicated with the bottom of the vacuum tank 1 through the conveyor 2. When the conveyor 2 works, the powdered injection is transported upwards into the vacuum tank 1. The vacuum tank 1 of the freeze-drying device body is in a negative pressure state, and under the negative pressure state, water sublimation is used for drying. The injection in the upper layer of the vacuum tank 1 is dried earlier than the injection in the lower layer. During the drying process, the first motor 7 drives the first rotating shaft 4 to rotate, thereby driving the spiral plate 3 on the first rotating shaft 4 to rotate, and the lower end of the spiral plate is inserted into the For the injection on the upper layer, the spiral plate 3 will scoop up the injection on the upper layer when it rotates, making it move upward along the spiral plate 3 . The injection on the upper layer enters the vacuum tank 1 first, and the injection on the upper layer is close to the drying requirement first. Even if the injection on the upper layer is removed, it is beneficial to the drying of the injection on the lower layer, improving the drying efficiency, and can discharge continuously. When the injection is on the spiral plate 3, it can also be freeze-dried. The injection on the spiral plate 3 is dispersed, the evaporation area is improved, and the drying efficiency is higher. During the rotation of the spiral plate 3, the lifting rods 9 arranged on both sides above the spiral plate 3 also rotate synchronously thereupon. The lifting rod 9 is provided with a screw rod 10, and the screw rod 10 is provided with a flexible sliding bar 11. 11 is slidably connected with the screw rod 10, and the slide bar 11 can slide back and forth along the screw rod 10 when subjected to an external force. The sliding bars 11 on both sides are connected to each other through the first scraper 12 , which can drive the first scraper 12 to move back and forth when the sliding bar 11 moves back and forth. There is a slide rail in the vacuum tank 1, one end of the connecting rod 13 is slidingly connected with the sliding rail, and the other end is slidingly connected with the sliding bar 11, the movement track of one end of the connecting rod 13 is the same as that of the track 14, and the connecting rod 13 is moving along the track 14 At this time, the sliding bar 11 is driven to move vertically upwards, downwards along the spiral plate 3, vertically downwards, and upwards along the spiral plate 3, thereby continuously moving the injection on the spiral plate 3 upwards. The upward moving injection reaches the top of the spiral plate 3 and falls into the material guide plate 5, then the material enters the collection ring 6 along the material guide plate 5, and enters the first discharge pipe 8 from the collection ring 6, and finally discharge.

Specifically, the track 14 includes several track 14 units sequentially connected into a closed loop, and the track 14 unit includes a first curved portion 15, a second curved portion 16, a third curved portion 17 and a fourth curved portion connected in sequence. The first bending portion 15 bends upward, the second bending portion 16 bends inward, the third bending portion 17 bends downward, and the fourth bending portion 18 bends outward. When the connecting rod 13 rotates, one end connected to the track 14 moves along the track 14 . The track 14 is composed of a plurality of track 14 units, and the track 14 unit includes 4 curved parts, which pass through the first curved part 15, the second curved part 16, the third curved part 17 and the fourth curved part in sequence when the connecting rod 13 slides 18. When passing through the first bending part 15, the connecting rod 13 moves upward, thereby driving the lifting rod 9 to lift upward, the first scraper 12 is separated from the injection on the spiral plate 3, and then the connecting rod 13 moves upward when passing through the second bending part 16. to push the sliding bar 11 to slide downward along the spiral plate 3, and then the connecting rod 13 moves downward when passing through the third curved part 17, thereby driving the lifting rod 9 to descend downward, and the first scraper 12 and the spiral plate 3 Contact, and finally the connecting rod 13 moves outward when passing through the fourth curved portion 18, thereby pulling the slide bar 11 to slide upward along the spiral plate 3, driving the first scraper 12 to move upward along the spiral plate 3 and pushing the injection upward. Using the power of the spiral plate 3 to rotate itself, the first scraper 12 is driven to alternately perform compound motions of intermittent spiral reciprocating motion and lifting motion. The scraping of the injection by the first scraper 12 is synchronized with the shoveling of the upper injection by the spiral plate 3, and the structure is simple. .

Specifically, the connecting rod 13 is V-shaped, one end of the connecting rod 13 is provided with a slider 19 sliding in the track 14 , and the other end is connected with the two sliding bars 11 . Optionally, the connecting rod 13 has certain elasticity. The slider 19 moves along the track 14, and drives the connecting rod 13 to move when moving, and the connecting rod 13 drives the two sliding bars 11 to move synchronously, so that the sliding bars 11 move synchronously.

Specifically, the conveyor 2 is a screw conveyor 2, and the conveyor 2 is used to transport the injection into the vacuum tank 1, and the storage tank is tightly connected with the vacuum tank 1 through threads. After the storage tank is installed at the bottom of the vacuum tank 1, it is tightly sealed to prevent outside air from entering the storage tank and the vacuum tank 1 under negative pressure. During the drying process, the injection agent is continuously conveyed upward by the screw conveyor 2 for drying.

Specifically, the inner ring of the collecting ring 6 is provided with a baffle plate 20, the outlet of the material guide plate 5 extends into the collecting ring 6, and the bottom of the collecting ring 6 is provided with an opening 21 , the opening 21 communicates through the first discharge pipe 8 , and the first discharge pipe 8 is provided with a control valve 22 . The baffle plate 20 prevents the injection on the material collecting ring 6 from falling out, and the injection coming out of the material guide plate 5 directly enters into the material collecting ring 6, and can always fall into the material collecting ring 6 when the material guide plate 5 rotates . A control valve 22 is provided on the first discharge pipe 8 to prevent outside air from entering the vacuum tank 1 from the first discharge pipe 8 under a negative pressure state.

Specifically, the control valve 22 includes a valve seat 23, a valve core 24, a rotating shaft 25 and a second scraper 26, the valve seat 23 is provided with a cylindrical cavity 27, and the side wall of the cylindrical cavity 27 A feed port and a discharge port are provided, the feed port is located on the opposite side of the discharge port, the valve core 24 is a positive prism, and the edge of the valve core 24 is in contact with the inner wall of the cylindrical cavity 27 Fitting, the rotating shaft 25 is connected with the valve core 24, the rotating shaft 25 rotates under the drive of the second motor 28, the discharge port is provided with the second scraper 26, the second scraper 26 is elastic and is attached to the side of the valve core 24 . The second motor 28 drives the rotating shaft 25 to rotate, thereby driving the spool 24 to rotate. When the spool 24 rotates, the edge is always attached to the cylindrical cavity 27, and a storage space is formed between the spool 24 and the inner wall of the cylindrical cavity 27. cavity. The side wall of the cylindrical cavity 27 is provided with a feed inlet and a discharge opening, the feed inlet is located on the opposite side of the discharge outlet, and the injection enters the cylindrical cavity 27 from the feed inlet, and the injection can enter the In the storage chamber, move to the position of the discharge port with the rotation of the valve core 24, and finally use the second scraper 26 at the discharge port to scrape off the injection, and the scraped injection enters the discharge port. In the process of rotation, the valve core 24 at the position of the discharge port will bring part of the air to the feed port, the air pressure in the storage chamber is higher than the air pressure at the discharge port, and the air is ejected from the storage chamber to push the injection, which can It has a loosening effect on the injection and keeps the injection loose. Since the injection is also discharged from the first discharge pipe 8, the air entering the feed port will basically not cause changes in the air pressure in the vacuum tank 1 . The valve core 24 is a positive prism, and the size of the storage chamber remains unchanged during the movement of the injection along with the storage chamber, so that the injection remains in a loose state. The control valve 22 can seal the first discharge pipe 8 while discharging, preventing outside air from entering the vacuum tank 1 from the second discharge pipe, so that the powdered injection is more loose.

Specifically, the outer surface of the valve core 24 is provided with a rubber layer. The sealing performance between the valve core 24 and the valve seat 23 is improved.

Specifically, the first discharge pipe 8 communicates with the buffer tank 31 . The injection coming out of the first discharge pipe 8 can enter the buffer tank 31 for buffering.

The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included in the scope of the present invention. within the scope of protection.

Claims

A freeze-drying device for drug injection preparations, comprising a freeze-drying device body, the freeze-drying device body including a vacuum tank, characterized in that a storage tank is arranged below the vacuum tank, and the storage tank is filled with powdery injection, the storage tank communicates with the bottom of the vacuum tank through a conveyor, and the vacuum tank is provided with a spiral plate, a first rotating shaft, a material guide plate, a collection ring and a first motor, and the first motor is connected to the The first rotating shaft is connected, the first rotating shaft is provided with the spiral plate, the lower end of the spiral plate is used to scrape out the upper injection, and the upper end is provided with the material guide plate, which is used for injecting the injection Imported into the collecting ring, the bottom of the collecting ring communicates with the first discharge pipe, the two sides above the spiral plate are provided with lifting rods, the lifting rods are connected with the screw rods, and the screw rods are slidably connected There are slide bars, the slide bars on both sides are connected to each other through the first scraper, the slide bar is provided with a connecting rod, and the other end of the connecting rod is slidingly connected with the track fixed in the vacuum tank; When the connecting rod slides along the track, it drives the slide bar to move up and down and to reciprocate along the spiral rod, so that the first scraper drives the injection to move upward along the spiral plate.
A freeze-drying device for drug injection preparations according to claim 1, wherein the track includes several track units sequentially connected to form a closed loop, and the track units include sequentially connected first curved parts , a second bent portion, a third bent portion and a fourth bent portion, the first bent portion is bent upward, the second bent portion is bent inward, the third bent portion is bent downward, and the fourth bent Curved outwards.
A freeze-drying device for drug injection preparations according to claim 1, wherein the connecting rod is V-shaped, one end of the connecting rod is provided with a slider sliding in the track, and the other end is connected to the The two sliders are connected.
A kind of freeze-drying equipment for drug injection preparation according to claim 1, characterized in that, the conveyor is a screw conveyor, and the conveyor is used to transport the injection into the vacuum tank, and the storage tank is threaded It is airtightly connected with the vacuum tank.
A kind of freeze-drying equipment for drug injection preparation according to claim 1, characterized in that, the inner ring of the collection ring is provided with a baffle, and the outlet of the guide plate extends into the collection In the ring, the bottom of the collection ring is provided with an opening, and the opening is connected through a first discharge pipe, and the first discharge pipe is provided with a control valve.
A freeze-drying device for drug injection preparations according to claim 5, wherein the control valve includes a valve seat, a valve core, a rotating shaft and a second scraper, and a cylindrical hollow is arranged inside the valve seat. Cavity, the side wall of the cylindrical cavity is provided with a feed port and a discharge port, the feed port is located on the opposite side of the discharge port, the valve core is a positive prism, and the edge of the valve core The side is attached to the inner wall of the cylindrical cavity, the rotating shaft is connected with the valve core, the rotating shaft rotates under the drive of the second motor, the discharge port is provided with the second scraper, and the first The two scrapers are elastic and adhere to the side of the valve core.
The freeze-drying device for pharmaceutical injection preparations according to claim 6, wherein a rubber layer is provided on the outer surface of the valve core.
A freeze-drying device for pharmaceutical injection preparations according to claim 1, wherein the first discharge pipe is in communication with a buffer tank.