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  • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
  • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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  • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
  • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
  • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
• • A—HUMAN NECESSITIES
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  • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
  • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
  • C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
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  • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
  • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
  • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
  • C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
  • C07C217/70—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
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  • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
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  • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
  • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
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  • C07C317/00—Sulfones; Sulfoxides
  • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
  • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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  • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
  • C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
  • C07C321/28—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
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  • C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
  • C07C381/10—Compounds containing sulfur atoms doubly-bound to nitrogen atoms
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  • C07C2602/00—Systems containing two condensed rings
  • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
  • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
  • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Definitions

• indoleamines can be classified into three main classes: indoleamines, phenylalkylamines, and ergolines.
• the first class, indolamines includes N,N- dimethyltryptamine (DMT), 5-methoxy-DMT (5-MeO-DMT), psilocybin and 4-hydroxy- DMT.
• the second class, phenylalkylamines includes mescaline, as well as synthetic mescaline analogs such as 2,5-dimethoxy-4-iodoamphetamine (DOI) and 2,5-dimethoxy-4- bromoamphetamine (DOB).
• DOI 2,5-dimethoxy-4-iodoamphetamine
• DOB 2,5-dimethoxy-4- bromoamphetamine
• the third class are ergolines, such as LSD.
• the phenylalkylamines are selective agonists of 5-HT2 receptors, including 5- HT2A, 5- HT2B and 5-HT2C receptors.
• the indoleamines and ergolines act as partial agonists of 5-HT1, 5-HT2, 5-HT6 and 5-HT7 receptors. LSD and other ergolines also act upon D 1 and D2 dopamine receptors and adrenergic receptors.
• the present disclosure provides compounds which act as agonists of serotonin receptors e.g., the 5-HT2A receptor, as well as compositions and methods of use thereof e.g., for the treatment of a mental health disease or disorder.
• the present disclosure provides a compound of Formula (I):
• Ri is independently at each position hydrogen, C1-C6 alkyl or C1-C6 haloalkyl
• R2 and R3 are independently hydrogen, C1-C 6 alkyl, C1-C 6 haloalkyl, halogen, cyano, ORi or SRi, wherein at least one of R2 and R3 is hydrogen;
• the present disclosure provides a compound of Formula (I- A):
• the present disclosure provides a compound of Formula (II):
• Ri is independently at each position hydrogen, C1-C6 alkyl, or C1-C6 haloalkyl
• R8 and R9 are independently hydrogen, C1-C6 alkyl, C1-C4 alkyl, C3-C6 cycloalkyl, C3-C10 cycloalkyl, CH2OH, or CH2O-C1-C4 alkyl;
• Rio and R11 are independently hydrogen, halogen, C1-C6 alkyl, OH, C1-C4 alkyl, C3-C6 cycloalkyl, or CH2O-C1-C4 alkyl;
• R12 is hydrogen, CH2OH, CH2O-C1-C9 alkyl, C3-C10 cycloalkyl, CH2OH, or CH2O-C1-C4 alkyl;
• Ri 3 is hydrogen, C1-C9 alkyl, C3-C10 cycloalkyl, or CH2OH, CH2O-C1-C4 alkyl;
• the present disclosure provides a compound of Formula (P-A):
• the present disclosure provides a pharmaceutical composition
• a pharmaceutical composition comprising a compound of Formula (I), or Formula (II), or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient.
• the present disclosure provides a method of treating a mental health disease or disorder in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound of Formula (I), or Formula (II), or a pharmaceutically acceptable salt thereof.
• FIG. 1 depicts EC50 profiles of Compounds 1-1, 1-2, and 2-1 comparing 5-HT2A Gq and b-arrestin biased signaling.
• the term “about” when immediately preceding a numerical value means a range (e.g., plus or minus 10% of that value).
• “about 50” can mean 45 to 55
• “about 25,000” can mean 22,500 to 27,500, etc., unless the context of the disclosure indicates otherwise, or is inconsistent with such an interpretation.
• “about 50” means a range extending to less than half the interval(s) between the preceding and subsequent values, e.g., more than 49.5 to less than 50.5.
• the phrases “less than about” a value or “greater than about” a value should be understood in view of the definition of the term “about” provided herein.
• the term “about” when preceding a series of numerical values or a range of values refers, respectively to all values in the series, or the endpoints of the range.
• administer refers to administering a compound or pharmaceutically acceptable salt of the compound or a composition or formulation comprising the compound or pharmaceutically acceptable salt of the compound to a patient.
• treating refers to improving at least one symptom of the patient's or subject’s disorder.
• treating can be improving, or at least partially ameliorating a disorder or one or more symptoms of a disorder.
• terapéuticaally effective applied to dose or amount refers to that quantity of a compound or pharmaceutical formulation that is sufficient to result in a desired clinical benefit after administration to a patient or subject in need thereof.
• salts includes both acid and base addition salts.
• Pharmaceutically acceptable salts include those obtained by reacting the active compound functioning as a base, with an inorganic or organic acid to form a salt, for example, salts of hydrochloric acid, sulfuric acid, phosphoric acid, methanesulfonic acid, camphorsulfonic acid, oxalic acid, maleic acid, succinic acid, citric acid, formic acid, hydrobromic acid, benzoic acid, tartaric acid, fumaric acid, salicylic acid, mandelic acid, carbonic acid, etc.
• the acids that may be used to prepare pharmaceutically acceptable acid addition salts of such basic compounds are those that form non-toxic acid addition salts, i.e., salts containing pharmaceutically acceptable anions, including but not limited to malate, oxalate, chloride, bromide, iodide, nitrate, acetate, tartrate, oleate, fumarate, formate, benzoate, glutamate, methanesulfonate, benzenesulfonate, and p-toluenesulfonate salts.
• non-toxic acid addition salts i.e., salts containing pharmaceutically acceptable anions, including but not limited to malate, oxalate, chloride, bromide, iodide, nitrate, acetate, tartrate, oleate, fumarate, formate, benzoate, glutamate, methanesulfonate, benzenesulfonate, and p-toluene
• Base addition salts include but are not limited to, ethylenediamine, N-methyl-glucamine, lysine, arginine, ornithine, choline, N,N'- dibenzylethylenediamine, chloroprocaine, diethanolamine, procaine, N- benzylphenethylamine, diethylamine, piperazine, tris-(hydroxymethyl)-aminomethane, tetramethylammonium hydroxide, triethylamine, dibenzylamine, ephenamine, dehydroabietylamine, N-ethylpiperidine, benzylamine, tetramethylammonium, tetraethylammonium, methylamine, dimethylamine, trimethylamine, ethylamine, basic amino acids, e.
• lysine and arginine dicyclohexylamine and the like examples include lithium, sodium, potassium, magnesium, calcium salts and the like.
• metal salts include lithium, sodium, potassium, magnesium, calcium salts and the like.
• ammonium and alkylated ammonium salts include ammonium, methylammonium, dimethylammonium, trimethylammonium, ethylammonium, hydroxyethylammonium, diethylammonium, butylammonium, tetramethylammonium salts and the like.
• organic bases include lysine, arginine, guanidine, diethanolamine, choline and the like.
• C1-C 6 alkyl is intended to encompass Ci, C2, C3, C4, C5, C6, Ci-6, Ci-5, Ci-4, Ci-3, Ci -2, C2- 6 , C2-5, C2-4, C2-3, C 3 - 6 , C3-5, C3-4, C4- 6 , C4-5, and C5- 6 alkyl.
• Alkyl or “alkyl group” refers to a fully saturated, straight or branched hydrocarbon chain having from one to twelve carbon atoms, and which is attached to the rest of the molecule by a single bond. Alkyls comprising any number of carbon atoms from 1 to 12 are included. An alkyl comprising up to 12 carbon atoms is a C1-C12 alkyl, an alkyl comprising up to 10 carbon atoms is a C1-C1 0 alkyl, an alkyl comprising up to 6 carbon atoms is a C1-C 6 alkyl and an alkyl comprising up to 5 carbon atoms is a C1-C5 alkyl.
• a C1-C5 alkyl includes C5 alkyls, C4 alkyls, C3 alkyls, C2 alkyls and Ci alkyl (z.e., methyl).
• a C1-C 6 alkyl includes all moieties described above for C1-C5 alkyls but also includes Ce alkyls.
• a C1-C1 0 alkyl includes all moieties described above for C1-C5 alkyls and C1-C 6 alkyls, but also includes C7, Cs, C 9 and C10 alkyls.
• a C1-C12 alkyl includes all the foregoing moieties, but also includes C11 and C12 alkyls.
• Non-limiting examples of C1-C12 alkyl include methyl, ethyl, «-propyl, z-propyl, sec-propyl, zz-butyl , z-butyl, sec-butyl, /-butyl, zz-pentyl, /-amyl, zz-hexyl, zz-heptyl , zz-octyl, n- nonyl, zz-decyl, zz-undecyl, and zz-dodecyl.
• an alkyl group can be optionally substituted.
• Cycloalkyl refers to a stable non-aromatic monocyclic or polycyclic fully saturated hydrocarbon consisting solely of carbon and hydrogen atoms, which can include fused, bridged, or spirocyclic ring systems, having from three to twenty carbon atoms (e.g., having from three to ten carbon atoms) and which is attached to the rest of the molecule by a single bond.
• Monocyclic cycloalkyls include, for example, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl.
• Polycyclic cycloalkyls include, for example, adamantyl, norbomyl, decalinyl, 7,7-dimethyl-bicyclo[2.2.1]heptanyl, and the like. Einless otherwise stated specifically in the specification, a cycloalkyl group can be optionally substituted.
• Haloalkyl refers to an alkyl, as defined above, that is substituted by one or more halo radicals, e.g ., trifluoromethyl, difluoromethyl, trichloromethyl, 2,2,2-trifluoroethyl, 1,2-difluoroethyl, 3-bromo-2-fluoropropyl, 1,2-dibromoethyl, and the like. Unless stated otherwise specifically in the specification, a haloalkyl group can be optionally substituted.
• Heterocyclyl refers to a stable saturated, unsaturated, or aromatic 3- to 20-membered ring which consists of two to nineteen carbon atoms and from one to six heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and which is attached to the rest of the molecule by a single bond.
• Heterocyclyl or heterocyclic rings include heteroaryls, heterocyclylalkyls, heterocyclylalkenyls, and hetercyclylalkynyls.
• the heterocyclyl can be a monocyclic, bicyclic, tricyclic or tetracyclic ring system, which can include fused, bridged, or spirocyclic ring systems; and the nitrogen, carbon or sulfur atoms in the heterocyclyl can be optionally oxidized; the nitrogen atom can be optionally quaternized; and the heterocyclyl can be partially or fully saturated.
• heterocyclyl examples include, but are not limited to, dioxolanyl, thienyl[l,3]dithianyl, decahydroisoquinolyl, imidazolinyl, imidazolidinyl, isothiazolidinyl, isoxazolidinyl, morpholinyl, octahydroindolyl, octahydroisoindolyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, oxazolidinyl, piperidinyl, piperazinyl, 4-piperidonyl, pyrrolidinyl, pyrazolidinyl, quinuclidinyl, thiazolidinyl, tetrahydrofuryl, trithianyl, tetrahydropyranyl, thiomorpholinyl, thiamorpholinyl, 1-oxo-thiomorph
• substituted means any of the groups described herein (e.g, alkyl, alkenyl, alkynyl, alkoxy, aryl, cycloalkyl, cycloalkenyl, cycloalkynyl, haloalkyl, heterocyclyl, and/or heteroaryl) wherein at least one hydrogen atom is replaced by a bond to a non-hydrogen atoms such as, but not limited to: a halogen atom such as F, Cl, Br, and I; an oxygen atom in groups such as hydroxyl groups, alkoxy groups, and ester groups; a sulfur atom in groups such as thiol groups, thioalkyl groups, sulfone groups, sulfonyl groups, and sulfoxide groups; a nitrogen atom in groups such as amines, amides, alkylamines, dialkylamines, arylamines, alkylaryl
• “Substituted” also means any of the above groups in which one or more hydrogen atoms are replaced by a higher-order bond (e.g., a double- or triple-bond) to a heteroatom such as oxygen in oxo, carbonyl, carboxyl, and ester groups; and nitrogen in groups such as imines, oximes, hydrazones, and nitriles.
• a higher-order bond e.g., a double- or triple-bond
• nitrogen in groups such as imines, oximes, hydrazones, and nitriles.
• R g and Rh are the same or different and independently hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkylamino, thioalkyl, aryl, aralkyl, cycloalkyl, cycloalkenyl, cycloalkynyl, cycloalkylalkyl, haloalkyl, haloalkenyl, haloalkynyl, heterocyclyl, l-heterocyclyl, heterocyclylalkyl, heteroaryl, A-heteroaryl and/or heteroarylalkyl.
• “Substituted” further means any of the above groups in which one or more hydrogen atoms are replaced by a bond to an amino, cyano, hydroxyl, imino, nitro, oxo, thioxo, halo, alkyl, alkenyl, alkynyl, alkoxy, alkylamino, thioalkyl, aryl, aralkyl, cycloalkyl, cycloalkenyl, cycloalkynyl, cycloalkylalkyl, haloalkyl, haloalkenyl, haloalkynyl, heterocyclyl, A-heterocyclyl, heterocyclylalkyl, heteroaryl, A-heteroaryl and/or heteroarylalkyl group.
• each of the foregoing substituents can also be optionally substituted with one or more of the above substituents.
• the present disclosure provides compounds which act as agonists of the 5-HT2A receptor.
• the compounds are full agonists of the 5-HT2A receptor.
• the compounds are partial agonists of the 5-HT2A receptor.
• the compounds display selectivity for 5-HT2A receptor.
• Activation of 5- HT2A receptors located in cortical and subcortical structures of the brain are thought to mediate the subjective, behavioral and psychological effects of psychedelics in both animals and humans.
• psychedelics In rodents, psychedelics have shown to elicit a ‘head twitch response’ which has been demonstrated to be a direct and selective consequence of 5- HT2A activation over other similar serotonin receptors including both 5-HT2C and 5-HT2B (Halberstadt, A. L., Behav. Brain Res.277, 99-120 (2015); Winter et ah, Pharmacol. Biochem.
• 5-HT2A is the predominant driver of psychedelic effects in humans
• other serotonin receptors like 5-HT1A
• LSD and lisuride both activate the 5-HT2A receptor but in slightly different ways which result in the activation of different intracellular signaling cascades.
• LSD and lisuride have been shown to active canonical Gq-based signaling downstream of 5-HT2A, but only LSD stimulated the expression of early growth response proteins (EGR1 and EGR2) by activating Gi/o subunits and the SRC protein kinase (Gonzalez-Maeso et al, Neuron 53, 439-452 (2007)).
• the present disclosure provides a compound of Formula (I):
• Ri is independently at each position hydrogen, C1-C 6 alkyl, or C1-C 6 haloalkyl
• R2 and R3 are independently hydrogen, C1-C 6 alkyl, C1-C 6 haloalkyl, halogen, cyano, ORi or SRi, wherein at least one of R2 and R3 is hydrogen;
• the compound of Formula (I) is a compound of Formula (I-A) or a pharmaceutically acceptable salt thereof; wherein, Ri, R2, R 3 R4, Rs and R6 are defined herein.
• Ri is independently at each position hydrogen, C1-C 6 alkyl, or C1-C 6 haloalkyl.
• Ri is independently at each position hydrogen or C1-C6 alkyl.
• Ri is independently at each position C1-C6 alkyl.
• Ri is independently at each position C1-C6 haloalkyl. In some embodiments, Ri is independently at each position Ci- C3 haloalkyl. In some embodiments, Ri is independently at each position CF3.
• Ri is independently at each position C1-C3 alkyl.
• Ri is independently at each position methyl, ethyl, propyl, or isopropyl.
• Ri is methyl
• R2 and R3 are independently hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, halogen, cyano, ORi or SRi, wherein at least one of R2 and R3 is hydrogen.
• R2 and R3 are independently hydrogen, C1-C6 alkyl, halogen, cyano, ORi or SRi, wherein at least one of R2 and R3 is hydrogen.
• R2 and R3 are independently hydrogen, halogen. C1-C6 alkyl, or C1-C6 haloalkyl, wherein at least one of R2 and R3 is hydrogen.
• R2 and R3 are independently hydrogen, halogen, C1-C3 alkyl, or C1-C3 haloalkyl, wherein at least one of R2 and R3 is hydrogen.
• R2 and R3 are independently hydrogen, C1-C6 alkyl, or C1-C6 haloalkyl, wherein at least one of R2 and R3 is hydrogen.
• R2 and R3 are independently hydrogen, C1-C3 alkyl, or Ci-C3haloalkyl, wherein at least one of R2 and R3 is hydrogen.
• R2 and R3 are independently hydrogen, or C1-C6 alkyl, wherein at least one of R2 and R3 is hydrogen.
• R2 and R3 are independently hydrogen, or C1-C3 alkyl, wherein at least one of R2 and R3 is hydrogen.
• R2 and R3 are independently hydrogen, -CF3, methyl or ethyl, wherein at least one of R2 and R3 is hydrogen.
• R2 and R3 are independently hydrogen, methyl or ethyl, wherein at least one of R2 and R3 is hydrogen.
• R2 and R3 are independently hydrogen or methyl, wherein at least one of R2 and R3 is hydrogen.
• R2 is hydrogen, -CF3, methyl or ethyl and R3 is hydrogen.
• R2 is hydrogen, methyl or ethyl and R3 is hydrogen.
• R2 is hydrogen and R3 is hydrogen, -CF3, methyl or ethyl.
• R2 is hydrogen and R3 is hydrogen, methyl or ethyl.
• R2 and R3 are hydrogen.
• R2 is halogen and R3 is hydrogen.
• R2 is iodo and R3 is hydrogen.
• R2 is hydrogen and R3 is halogen.
• R2 is hydrogen and R3 is iodo.
• R4 is Ci-C6alkyl or Ci-C 6 haloalkyl.
• R4 is Ci-C 6 alkyl.
• R4 is -CF3 or methyl.
• R4 is methyl
• R6 is hydrogen
• n is an integer from 0-3 (i.e. 0, 1, 2, or 3). In some embodiments, n is 1 or 2. In some embodiments, n is 0. In some embodiments n is 1. In some embodiments n is 2. In some embodiments n is 3.
• Ri is independently at each position hydrogen, C1-C6 alkyl, or C1-C6 haloalkyl;
• R8 and R 9 are independently hydrogen, C1-C 6 alkyl, C1-C4 alkyl, C 3 -C 6 cycloalkyl, C 3 -C1 0 cycloalkyl, CH2OH, or CH2O-C1-C4 alkyl;
• Rio and R11 are independently hydrogen, halogen, C1-C6 alkyl, OH, C1-C4 alkyl, C3-C6 cycloalkyl, or CH2O-C1-C4 alkyl;
• R12 is hydrogen, CH2OH, CH2O-C1-C9 alkyl, C3-C10 cycloalkyl, CH2OH, or CH2O-C1-C4 alkyl;
• Ri 3 is hydrogen, C1-C 9 alkyl, C 3 -C1 0 cycloalkyl, or CH2OH, CH2O-C1-C4 alkyl.
• the compound of Formula (II) is: or a pharmaceutically acceptable salt thereof; wherein,
• Ri is independently at each position hydrogen, C1-C 6 alkyl, or C1-C 6 haloalkyl
• R2, R3 and R7 are independently hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, halogen, cyano, ORi or SRi, wherein at least one of R2 and R3 is hydrogen;
• R8 and R 9 are independently hydrogen or C1-C 6 alkyl
• Rio, and R11 are independently hydrogen, halogen or C1-C6 alkyl
• R12 is hydrogen, CH2OH, CH2O-C1-C9 alkyl, C3-C10 cycloalkyl, CH2OH, CH2O-C1 to C4 alkyl;
• Ri 3 is hydrogen, C1-C 9 alkyl, C 3 -C1 0 cycloalkyl, CH2OH, CH2O-C1 to C4 alkyl.
• the compound of Formula (II) is a compound of Formula (P-A): or a pharmaceutically acceptable salt thereof; wherein,
• Ri is independently at each position hydrogen, C1-C 6 alkyl, or C1-C 6 haloalkyl
• R2, R3 and R7 are independently hydrogen, C1-C 6 alkyl, C1-C 6 haloalkyl, halogen, cyano, ORi or SRi, wherein at least one of R2 and R3 is hydrogen;
• R8 and R 9 are independently hydrogen or C1-C 6 alkyl; and Rio and R11 are independently hydrogen, halogen or C1-C 6 alkyl.
• the compound of Formula (II) is a compound of Formula (P-B):
• Ri is independently at each position hydrogen, C1-C6 alkyl, or C1-C6 haloalkyl.
• Ri is independently at each position hydrogen or C1-C6 alkyl.
• Ri is independently at each position C1-C6 alkyl.
• Ri is independently at each position C1-C3 alkyl.
• Ri is independently at each position methyl, ethyl, propyl, or isopropyl.
• Ri is independently at each position C1-C6 haloalkyl. In some embodiments, Ri is independently at each position C1-C3 haloalkyl. In some embodiments, Ri is independently at each position CF3.
• Ri is methyl
• R2, and R3 are independently hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, halogen, cyano, ORi or SRi, wherein at least one of R2 and R3 is hydrogen.
• R2, and R3 are independently hydrogen, C1-C6 alkyl, halogen, cyano, ORi or SRi, wherein at least one of R2 and R3 is hydrogen.
• R2 and R3 are independently hydrogen, halogen. C1-C6 alkyl, or C1-C6 haloalkyl, wherein at least one of R2 and R3 is hydrogen.
• R2 and R3 are independently hydrogen, halogen, C1-C3 alkyl, or C1-C3 haloalkyl, wherein at least one of R2 and R3 is hydrogen.
• R2 and R3 are independently hydrogen, C1-C6 alkyl, or C1-C6 haloalkyl, wherein at least one of R2 and R3 is hydrogen.
• R2 and R3 are independently hydrogen, C1-C3 alkyl, or Ci-C3haloalkyl, wherein at least one of R2 and R3 is hydrogen.
• R2 and R3 are independently hydrogen, or C1-C6 alkyl, wherein at least one of R2 and R3 is hydrogen.
• R2 and R3 are independently hydrogen, or C1-C3 alkyl, wherein at least one of R2 and R3 is hydrogen.
• R2 and R3 are independently hydrogen, -CF3, methyl or ethyl, wherein at least one of R2 and R3 is hydrogen.
• R2 and R3 are independently hydrogen, methyl or ethyl, wherein at least one of R2 and R3 is hydrogen.
• R2 and R3 are independently hydrogen or methyl, wherein at least one of R2 and R3 is hydrogen.
• R2 is hydrogen, -CF3, methyl or ethyl and R3 is hydrogen.
• R2 is hydrogen, methyl or ethyl and R3 is hydrogen.
• R3 is hydrogen
• R2 is hydrogen
• R2 is hydrogen and R3 is hydrogen, -CF3, methyl or ethyl.
• R2 is hydrogen and R3 is hydrogen, methyl or ethyl.
• R2 and R3 are hydrogen.
• R2 is halogen and R3 is hydrogen.
• R2 is hydrogen and R3 is halogen.
• R4 is Ci- Cealkyl or Ci-C6haloalkyl.
• R4 is Ci- Cealkyl
• R4 is -CF3 or methyl.
• R4 is methyl
• R6 is hydrogen
• R7 is hydrogen
• Rio and R11 are fluoro.
• R11 andRi2 are hydrogen.
• provided herein is one or more compounds selected from Table 1 [0117] In some embodiments, provided herein is one or more pharmaceutically acceptable salts of a compound selected from Table 1.
• provided herein is one or more pharmaceutically acceptable salts of a compound selected from Table 2.
• a pharmaceutical composition comprising a therapeutically effective amounts of one or more compounds of the present disclosure (e.g., a compound of Formula (I), (I- A) (II), (II- A), (II-B), Table 1 or Table 2) or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient is provided.
• a pharmaceutical composition comprising one or more compounds disclosed herein, or a pharmaceutically acceptable salt thereof, further comprise a pharmaceutically acceptable carrier.
• a pharmaceutically acceptable carrier includes a pharmaceutically acceptable excipient, binder, and/or diluent.
• suitable pharmaceutically acceptable carriers include, but are not limited to, inert solid fillers or diluents and sterile aqueous or organic solutions.
• suitable pharmaceutically acceptable excipients include, but are not limited to, water, salt solutions, alcohol, polyethylene glycols, gelatin, lactose, amylase, magnesium stearate, talc, silicic acid, viscous paraffin, and the like.
• the compounds of the present disclosure can be formulated for administration by a variety of means including orally, parenterally, by inhalation spray, topically, or rectally in formulations containing pharmaceutically acceptable carriers, adjuvants and vehicles.
• parenteral as used here includes subcutaneous, intravenous, intramuscular, and intraarterial injections with a variety of infusion techniques.
• Intraarterial and intravenous injection as used herein includes administration through catheters.
• the compounds of the present disclosure find use, for example, in methods for modulating a serotonin receptor, e.g., 5-HT2A receptor. Accordingly, in some embodiments, the present disclosure provides the use of any one of compounds of the present disclosure (e.g., a compound of Formula (I), (I-A), (II), (II-A), (II-B), Table 1 or Table 2) or a pharmaceutically acceptable salt thereof, for modulating serotonin receptor activity.
• Modulating serotonin (e.g., 5-HT2A) receptor activity can be in a subject in need thereof (e.g., a mammalian subject, such as a human) and for treatment of any of the described conditions or diseases.
• modulating is activating or agonizing a serotonin receptor, e.g., 5-HT2A receptor.
• the subject is a human.
• the present disclosure provides methods of treating a disease or disorder that is treatable by administration of a serotonin receptor agonist, e.g., 5-HT2A receptor agonist.
• a serotonin receptor agonist e.g., 5-HT2A receptor agonist.
• the agonist is a partial agonist of the 5-HT2A receptor.
• the agonist is a full agonist of the 5-HT2A receptor.
• the compounds of the present disclosure are used for treating, a mental health disease or disorder in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound of the present disclosure (e.g., e.g., a compound of Formula (I), (I-A), (II), (II- A), (II-B) Table 1 or Table 2 or a pharmaceutically acceptable salt thereof) or a pharmaceutical composition comprising a compound of the present disclosure (e.g., e.g., a compound of Formula (I), (I-A), (II), (II-A), (II-B), Table 1 or Table 2 or a pharmaceutically acceptable salt thereof) and a pharmaceutically acceptable excipient.
• a compound of the present disclosure e.g., e.g., a compound of Formula (I), (I-A), (II), (II-A), (II-B) Table 1 or Table 2 or a pharmaceutically acceptable salt thereof
• the mental health disease or disorder is selected from the group consisting of depression, substance use disorders (SUD) and eating disorders.
• the mental health disease or disorder is an eating disorder.
• Eating disorders include illnesses such as anorexia nervosa, bulimia nervosa, and other disorders related to eating (e.g., binge eating).
• the mental health disease or disorder is a mood disorder.
• Mood disorders include e.g., depressive disorders, such as major depressive disorder or treatment resistant depression.
• the mental health disorder is a substance abuse disorder.
• substance use related disorders are disorders of maladaptive patterns of substance use, and include criteria, such as recurrent substance use related problems, tolerance to a substance, withdrawal upon discontinuing use, an inability to cut down or control use of the substance, and giving up important social, occupational, or recreational activities because of using the substance. See e.g., the Diagnostic and Statistical Manual of Mental Disorders (DSM-5).
• the substance use related disorder is a disorder resulting from the use of: alcohol; caffeine; cannabis; hallucinogens (such as phencyclidine or similarly acting arylcyclohexylamines, and other hallucinogens, such as LSD); inhalants; opioids; sedatives, hypnotics, or anxiolytics; stimulants (including amphetamine-type substances, cocaine, and other stimulants); tobacco; and other substances.
• hallucinogens such as phencyclidine or similarly acting arylcyclohexylamines, and other hallucinogens, such as LSD
• inhalants such as phencyclidine or similarly acting arylcyclohexylamines, and other hallucinogens, such as LSD
• opioids such as phencyclidine or similarly acting arylcyclohexylamines, and other hallucinogens, such as LSD
• inhalants such as phencyclidine or similarly acting arylcyclohexylamines,
• LC-MS analyses were performed on Shimadzu LCMS-2020 equipped with LC-20AD or 30AD pumps, SPD-M20APDA and Alltech 3300 ELSD; Mobile Phase: A:Water (0.1% Formic acid), B: ACN; 5 minute run; Column: Sepax BR-C18 4.6*50mm,3um; Flow Rate: LOml/min; Oven Temperature: 40°C; Gradient: 20% B for 0.2 min, increase to70% B within 1.8 min, 70% B for 2.8 min, back to 20% B within 0.2 min, 20% B for 2 min).
• Preparative TLC was performed on Whatman LK6F Silica Gel 60 A size 20x20 cm plates with a thickness of 1000 pm or equivalent.
• Example 1 Synthesis of N-(3-chloro-5-methylbenzyl)-5,8-dimethoxy-l, 2,3,4- tetrahydronaphthalen-2-amine hydrochloride (1-1 ⁇ HO) [0132] To a solution of 5,8-dimethoxy-3,4-dihydronaphthalen-2(lH)-one (400 mg, 1.94 mmol, 1.0 eq.) and (3-chloro-5-methylphenyl) methanamine hydrochloride (380 mg, 1.94 mmol, 1.0 eq.) in CH2CI2 (10 ml) was added NaBH(OAc)3 (600 mg, 2.83 mmol, 1.5 eq.).
• Example 2 Synthesis of N-(3-chloro-5-methylbenzyl)-6-iodo-5,8-dimethoxy-l, 2,3,4- tetrahydronaphthalen-2- amine (1-2A) and N-(3-chloro-5-methylbenzyl)-7-iodo-5,8- dimethoxy-l,2,3,4-tetrahydronaphthalen-2- amine (1-2B)
• Example 7 N-(4-chloro-3-methylbenzyl)-5,8-dimethoxy-l,2,3,4-tetrahydronaphthalen- 2-amine (1-7) [0138] The same procedure used for the preparation of 1-3 was applied to afford the title compound which was converted to the HC1 salt EGX-13-6-HC1 (35 mg, 30%) as a white solid after treatment with HC1 in dioxane. LCMS: m/z 345.9 [M+H] + .
• Step 2 EGX-9-1-2 [2,5-dimethoxy-3-methylbenzaldehyde]
• a solution of 2-hydroxy-5-methoxy-3-methylbenzaldehyde (5.0 g, 30.0 mmol, 1.0 eq), CH3I (8.5 g, 60.0 mmol, 2.0 eq) and K2CO3 (10.0 g) in DMF (20 mL) was stirred at RT overnight. TLC was monitored until the starting material was consumed.
• the reaction mixture was poured into water (30mL) and extracted with MTBE (50 mL c 3).
• Step 3 (E)-4-(2,5-dimethoxy-3-methylphenyl)but-3-enoic acid
• Step 5 5,8-dimethoxy-6-methyl-3,4-dihydronaphthalen-l(2H)-one
• Step 6 (E)-2-(hydroxyimino)-5,8-dimethoxy-6-methyl-3,4-dihydronaphthalen- l(2H)-one
• Step 7 N-(5,8-dimethoxy-6-methyl-l-oxo-l,2,3,4-tetrahydronaphthalen-2- yl)acetamide
• Step 8 N-(l-hydroxy-5,8-dimethoxy-6-methyl-l,2,3,4-tetrahydronaphthalen-2- yl)acetamide
• Step 9 2-amino-5,8-dimethoxy-6-methyl-l,2,3,4-tetrahydronaphthalen-l-ol
• Step 10 5,8-dimethoxy-6-methyl-l,2,3,4-tetrahydronaphthalen-2-amine
• Step 11 N-(3-chloro-5-methylbenzyl)-5,8-dimethoxy-6-methyl-l, 2,3,4- tetrahydronaphthalen-2-amine
• Step 12 N-(3-chloro-5-methylbenzyl)-5,8-dimethoxy-6-methyl-l, 2,3,4- tetrahydronaphthalen-2-amine hydrochloride
• Example 20 N-(3-chloro-5-methylbenzyl)-4,7-dimethoxy-2,3-dihydro-lH-inden-2-amine hydrochloride (1-20) [0162] The same procedure as for the preparation of 1-19 was applied to afford the title compound as a white solid (153 mg, 81%).
• Step 1 Preparation of 2-(2,5-dimethoxyphenyl)ethan-l-amine hydrochloride
• Step 2 [N-(3-chloro-5-methylbenzyl)-2-(2,5-dimethoxyphenyl)ethan-l-amine]
• Step 1 2-(2,5-dimethoxyphenyl)-N-(3-fluoro-5-methylbenzyl)ethan-l-amine
• 2-(2,5-dimethoxyphenyl)ethan-l-amine hydrochloride 105 mg, 0.58 mmol, 1.0 eq
• Et3N 110 mg
• NaBH(OAc)3 368.9 mg, 1.74 mmol, 3 eq.
• Step 2 2-(2,5-dimethoxyphenyl)-N-(3-fluoro-5-methylbenzyl)ethan-l-amine hydrochloride
• Example 27 N-(3,5-dichlorobenzyl)-2-(2,5-dimethoxyphenyl)ethan-l-amine (2-6) [0171] 3.18 (m, 2H), 3.05 - 2.93 (m, 2H).
• Step 1 l,4-dimethoxy-2-methyl-5-(2-nitrovinyl)benzene
• Step 3 EGX-15-2 N-(3-chloro-5-methylbenzyl)-2-(2,5-dimethoxy-4- methylphenyl)ethan-l-amine (2-28)
• Step 1 4-fluoro-2,5-dimethoxybenzaldehyde
• Step 2 l-fluoro-2,5-dimethoxy-4-(2-nitrovinyl)benzene
• Step 4 N-(3-chloro-5-methylbenzyl)-2-(4-fluoro-2,5-dimethoxyphenyl)ethan-l- amine (2-20)
• Step 1 2-(4-iodo-2,5-dimethoxyphenethyl)isoindoline-l,3-dione
• Step 2 4-(2-(l,3-dioxoisoindolin-2-yl)ethyl)-2,5-dimethoxybenzonitrile
• Step 4 4-(2-((3-chloro-5-methylbenzyl)amino)ethyl)-2,5-dimethoxybenzonitrile (2-23)
• Step 2 EGX-15-10-2 (2,5-dimethoxy-4-(2-nitrovinyl)phenyl)(methyl)sulfane
• Step 3 2-(2,5-dimethoxy-4-(methylthio)phenyl)ethan-l-amine hydrochloride
• the same procedures used for the preparation of 2-20 was applied to afford the title compound which was converted to the HC1 salt (332 mg, 83%) as a white solid after treatment with HC1 in dioxane.
• LCMS m/z 212 [M+H] + . l mAR (400 MHz, CDCb) d 6.74 (s, 1H), 6.52 (s, 1H), 3.88 (s, 3H), 3.83 (s, 3H), 3.80 (s, 3H), 3.00 (s, 2H), 2.80 (s, 2H).
• Step l (2,5-dimethoxy-4-(2-nitroethyl)phenyl)(methyl)sulfane
• Step 4 (3-chloro-5-methylbenzyl)-2-(2,5-dimethoxy-4- (methylsulfonyl)phenyl)ethan-l-amine
• Step 1 l,4-dimethoxy-2-methyl-5-(2-nitroprop-l-en-l-yl)benzene
• Step 2 l-(2,5-dimethoxy-4-methylphenyl)propan-2-amine
• Step 3 N-(3-chloro-5-methylbenzyl)-2-(2,5-dimethoxy-4-methylphenyl)propan-2- amine
• Step 1 2-amino-3-(2,5-dimethoxyphenyl)propan-l-ol
• Step 2 2-amino-3-(2,5-dimethoxyphenyl)propan-l-ol hydrochloride
• MTBE MTBE
• 4 M HC1 in dioxane 2 mL, >10 eq
• the resulting white solid was filtered and washed by MTBE to afford the title compound (180 mg, 90%).
• Step 3 2-((3-chloro-5-methylbenzyl)amino)-3-(2,5-dimethoxyphenyl)propan-l-ol
• Step 3 (E)-4-(2,5-dimethoxy-4-(2-nitrovinyl)phenyl)morpholine
• NH4OAC 11 mg, 0.15 mmol, 0.4 eq
• Step 5 N-(3-chloro-5-methylbenzyl)-2-(2,5-dimethoxy-4- morpholinophenyl)ethan-l-amine hydrochloride
• Step 1 tert-butyl(3-chloro-5-methylbenzyl)(2,5-dimethoxy-4- methylsulfinyl)phenethyl)-carbamate
• Step 2 tert-butyl(3-chloro-5-methylbenzyl)(2,5-dimethoxy-4-(S- methylsulfonimidoyl)-phenethyl)carbamate tert-butyl(3-chloro-5-methylbenzyl)(2,5-dimethoxy-4-(methylsulfmyl)phenethyl)carbamate (180 mg, 0.37 mmol, 1 eq) in MeOH (5 mL) was added ammonium carbamate (58 mg, 0.74 mmol, 2 eq) and (diacetoxyiodo)benzene (238 mg, 0.74 mmol, 2 eq).
• Step 3 (4-(2-((3-chloro-5-methylbenzyl)amino)ethyl)-2,5- dimethoxyphenyl)(imino)-(methyl)-16-sulfanone hydrochloride tert-butyl(3-chloro-5-methylbenzyl)(2,5-dimethoxy-4-(S-methylsulfonimidoyl)phenethyl)- carbamate (100 mg, 0.20 mmol, 1 eq) in DCM (10 mL) was added 4 M HC1 in dioxane (5 mL). The resulting mixture was stirred at RT for 16 h. LCMS indicated the reaction was complete.
• Step 4 (R)-(4-(2-((3-chloro-5-methylbenzyl)amino)ethyl)-2,5- dimethoxyphenyl)(imino)(methyl)-16-sulfanone (2-34)
• Step 1 l-(4-iodo-2, 5-dim ethoxyphenyl)propan-2-amine
• Step 2 N-(3-chloro-5-methylbenzyl)-l-(4-iodo-2,5-dimethoxyphenyl)propan-2- amine
• the PathHunter® b-Arrestin assay monitors the activation of a GPCR in a homogenous, non-imaging assay format using a technology developed by DiscoverX called Enzyme Fragment Complementation (EFC) with b-galactosidase (b-Gal) as the functional reporter.
• EFC Enzyme Fragment Complementation
• b-Gal b-galactosidase
• the enzyme is split into two inactive complementary portions (EA for Enzyme Acceptor and PK for ProLink) expressed as fusion proteins in the cell.
• EA is fused to b-Arrestin and PK is fused to the GPCR of interest.
• EA is fused to b-Arrestin and PK is fused to the GPCR of interest.
• PathHunter cell lines (DiscoveRx Eurofins) were expanded from freezer stocks according to standard procedures. Cells were seeded in a total volume of 20 pL into white walled, 384-well microplates and incubated at 37 °C for the appropriate time prior to testing. For agonist determination, cells were incubated with sample to induce response. Intermediate dilution of sample stocks was performed to generate 5X sample in assay buffer. 5 pL of 5X sample was added to cells and incubated at 37 °C or room temperature for 90 to 180 minutes. Vehicle concentration was 1%.
• the Calcium No-Wash PLUS assay monitors the activation of a GPCR via Gq secondary messenger signaling in a live cell, non- imaging assay format. Calcium mobilization in PathHunter® cell lines or other cell lines stably expressing Gq-coupled GPCRs is monitored using a calcium-sensitive dye that is loaded into cells. GPCR activation by a compound results in the release of calcium from intracellular stores and an increase in dye fluorescence that is measured in real-time.
• Cell lines expressing the GPCR of interest were expanded from freezer stocks according to standard procedures. Cells were seeded in a total volume of 20 pL into black- walled, clear-bottom, Poly-D-lysine coated 384-well microplates and incubated at 37°C for the appropriate time prior to testing. Assays were performed in 1 x Dye Loading Buffer consisting of lx Dye, lx Additive A and 2.5 mM Probenecid in HBSS / 20 mM Hepes. Probenicid was prepared fresh. Cells were loaded with dye prior to testing. Media was aspirated from cells and replaced with 20 pL Dye Loading Buffer. Cells were incubated for 30-60 minutes at 37°C.
• agonist determination cells were incubated with sample to induce response. After dye loading, cells were removed from the incubator and 10 pL HBSS / 20 mM Hepes was added. 3x vehicle was included in the buffer when performing agonist dose curves to define the EC80 for subsequent antagonist assays. Cells were incubated for 30 minutes at room temperature in the dark to equilibrate plate temperature. Intermediate dilution of sample stocks was performed to generate 4X sample in assay buffer. Compound agonist activity was measured on a FLIPR Tetra (MDS). Calcium mobilization was monitored for 2 minutes and 10 pL 4X sample in HBSS / 20 mM Hepes was added to the cells 5 seconds into the assay. Compound activity data was analyzed using CBIS data analysis suite (Chemlnnovation, CA). For agonist mode assays, percentage activity is calculated using the following formula:
• % Activity 100% x (mean RFU of test sample - mean RFU of vehicle control) / (mean MAX RFU control ligand - mean RFU of vehicle control).
• Compounds l-l’HCl, 1-2 and 2-1 were assessed for biological activity across a panel of 5-HT receptors including 5-HT2A, 5-HT2B, 5-HT2C and 5-HT1A. Biased signaling was assessed by monitoring both intracellular Gq-mediated calcium release, as well as beta-arrestin activation and recruitment to the GPCR. The results are shown in Table 3 below.
• the 5-HT2A activity is shown in Tables 4-5.
• selectivity is surprising and unexpected given the structural similarity between the 5-HT2A and 5-HT2B receptors.
• this selectivity will allow greater safety advantages over other non-selective psychedelics by potentially decreasing the risk of cardiac valvulopathy typically associated with prolonged 5-HT2B activation and repeat-dosing.
• Compound 1-2 showed approximately 7- and 10-fold greater potency for 5-HT1A and 5-HT2C than compound 1- l’HCl. All compounds also were potent activators of beta-arrestin recruitment at 5-HT2A at slightly lower potencies than Gq-mediated signaling suggesting a slight Gq signaling bias. Compound 2-1 was found to be the most potent of all compounds studied at 5-HT2A and 5- HT2C and displayed the greatest selectivity for 5-HT2A over 5-HT2B at -4400-fold. As with the other compounds, no appreciable activity was observed at 5-HT2B at concentrations less than 10 uM.
• Ri is independently at each position hydrogen, C1-C6 alkyl or C1-C6 haloalkyl
• R2 and R3 are independently hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, halogen, cyano, ORi or SRi, wherein at least one of R2 and R3 is hydrogen;
• Ri is independently at each position hydrogen, C1-C6 alkyl, or C1-C6 haloalkyl
• R8 and R9 are independently hydrogen, C1-C6 alkyl, C1-C4 alkyl, C3-C6 cycloalkyl, C3-C10 cycloalkyl, CH2OH, or CH2O-C1-C4 alkyl;
• Rio and R11 are independently hydrogen, halogen, C1-C6 alkyl, OH, C1-C4 alkyl, C3-C6 cycloalkyl, or CH2O-C1-C4 alkyl;
• R12 is hydrogen, CH2OH, CH2O-C1-C9 alkyl, C3-C10 cycloalkyl, CH2OH, or CH2O-C1-C4 alkyl;
• Ri 3 is hydrogen, C1-C9 alkyl, C3-C10 cycloalkyl, or CH2OH, CH2O-C1-C4 alkyl; and and n is an integer from 0-3.
• a pharmaceutical composition comprising the compound of any one of embodiments 1-40 and a pharmaceutically acceptable excipient.
• a method of treating a mental health disease or disorder comprising administering a therapeutically effective amount of a compound of any one of embodiments 1-40.
• the method of embodiment 42, wherein the mental health disease or disorder is a major depressive disorder, treatment resistant depression, substance use disorders or eating disorders.
• the compound of embodiment 1, wherein Formula (I) is a compound of Formula (I-

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