WO2022258405A1 - Composition topique pour l'équilibrage du microbiote de la peau - Google Patents

Composition topique pour l'équilibrage du microbiote de la peau Download PDF

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Publication number
WO2022258405A1
WO2022258405A1 PCT/EP2022/064511 EP2022064511W WO2022258405A1 WO 2022258405 A1 WO2022258405 A1 WO 2022258405A1 EP 2022064511 W EP2022064511 W EP 2022064511W WO 2022258405 A1 WO2022258405 A1 WO 2022258405A1
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WO
WIPO (PCT)
Prior art keywords
skin
staphylococcus
composition
genus
malassezia
Prior art date
Application number
PCT/EP2022/064511
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English (en)
Inventor
Xiaoying Bian
Chung-Ching Chu
Yuanyuan DIAO
Mingming PU
Yining XU
Original Assignee
Unilever Ip Holdings B.V.
Unilever Global Ip Limited
Conopco, Inc., D/B/A Unilever
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Unilever Ip Holdings B.V., Unilever Global Ip Limited, Conopco, Inc., D/B/A Unilever filed Critical Unilever Ip Holdings B.V.
Publication of WO2022258405A1 publication Critical patent/WO2022258405A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4933—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having sulfur as an exocyclic substituent, e.g. pyridinethione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin

Definitions

  • the present invention relates to a method of balancing microbiota of skin.
  • the skin is the largest organ of human body. It protects our body from external factors such as the environment, pollution and microbes. Our skin harbours a diverse range of microorganisms which live as a community and function as a component of skin biology. Due to the advent of next-generation sequencing technologies, we now know that the microbiome or microbiota of human skin is highly dependent on biophysical characteristics and chemical constitution of the skin. For example, sebaceous sites are dominated by Cutibacterium sp., whereas moist areas harbour Staphylococcus and Corynebacterium species. Any adverse alteration in the microbiome of our skin could lead to conditions e.g., dysbiosis, that may need at least cosmetic treatment as such seen in the case of acne, dry skin and dandruff.
  • the microbiome of skin can be balanced e.g. by reducing the overload microbial load or microbial count of skin but by selectively reducing some while selectively increasing the count of some others.
  • balancing the microbiota of skin refers to selectively increasing the microbial count of good microbes and/or reducing the same count of bad microbes.
  • Good microbes are said to provide benefit to their host through e.g., competing with bad microbes for available nutrients and through secretion of good metabolites.
  • balancing means reducing the ratio of level of Malassezia restricta to that of Malassezia globosa, or selectively reducing microbial count of at least one genus of microbes belong to Staphylococcus; wherein said skin is scalp having dandruff; wherein the said genus of microbes belong to Staphylococcus is Staphylococcus capitis.
  • a method of balancing microbiota of skin comprising a step of applying thereto zinc pyrithione or a piroctone compound in a topical composition, where balancing means reducing the ratio of level of Malassezia restricta to that of Malassezia globosa, or selectively reducing microbial count of at least one genus of microbes belong to Staphylococcus, wherein said skin is scalp having dandruff; wherein the said genus of microbes belong to Staphylococcus is Staphylococcus capitis.
  • composition comprising zinc pyrithione or a piroctone compound for use in balancing microbiota of skin, where balancing means reducing the ratio of level of Malassezia restricta to that of Malassezia globosa, or selectively reducing microbial count of at least one genus of microbes belong to Staphylococcus, while maintain the microbial count of at least one genus of microbes belong to Cuti bacterium; wherein said skin is scalp having dandruff
  • balancing means reducing the ratio of level of Malassezia restricta to that of Malassezia globosa, or selectively reducing microbial count of at least one genus of microbes belong to Staphylococcus, while maintain the microbial count of at least one genus of microbes belong to Cutibacterium preferably Cutibacterium aeries ; wherein said skin is scalp having dandruff.
  • a cosmetic composition as used herein, is meant to include a composition for topical application to skin, hair and/or scalp of mammals, especially human beings. Such a composition is generally applied on to the desired topical surface of the body for a period of time from a few seconds to up to 24 hours. When the period of time of application is low say of the order of a few seconds to a few minutes after which the composition is rinsed off with water or wiped away, such a composition is known as a cleansing composition or a wash-off composition. On the other hand, When the composition is applied for longer period of time say from several minutes to up to 24 hours and washed off usually during the process of normal personal cleaning, such a composition is known as a leave-on composition.
  • the composition as per the present invention includes any product applied to a human body for also improving appearance, cleansing, odor control or general aesthetics.
  • hair care composition is meant to include a composition for topical application to hair or scalp of mammals, especially humans.
  • topical is meant that the composition is applied to the external surface of the body. In the present invention this is achieved by applying the composition on the hair or scalp.
  • Such a composition may be generally classified as leave-on or rinse off, and includes any product applied for improving the appearance, cleansing, odor control or general aesthetics of scalp and hair.
  • the hair care composition of the present invention could be in the form of a liquid, lotion, cream, foam, scrub, gel, shampoo, conditioner, shower gel or bar.
  • the haircare composition of the present invention is preferably a leave-on composition.
  • the hair care composition of the present invention is a wash-off composition. Compositions for achieving the desired benefits by way of ingestion into the human body are excluded from the scope of the present invention.
  • balancing means selectively reducing the ratio of level of one species of microbes considered to be harmful to that of at least one genus of microbes considered to be beneficial, or reducing microbial count of at least one genus of microbes considered to be harmful or of at least one genus of microbes that exhibit growth which is not representation of a normal healthy skin, while selectively increasing microbial count of at least one genus of microbes considered to be beneficial or of at least one genus of microbes whose numbers have reduced which is also not representation of a normal healthy skin.
  • normal healthy skin preferably refers to skin which is free from any infection.
  • balancing means reducing or increasing the count of those microbes that have significantly changed in a condition as against healthy state. Such change could either be an abnormal increase or an abnormal decrease in their count.
  • a microbe can be described as a tiny living organism, such as bacterium, fungus, or virus.
  • a microbiome or microbiota refers collectively to all the microbes on or in the human body. In other words, a microbiome is a community of microbes.
  • a balanced microbiota containing diversity of organisms helps to maintain health and is essential for human development, immunity, health and wellbeing.
  • Each of our individual microbiomes adapts throughout our lifetime and people can achieve a healthy microbiome in different ways.
  • One way to regulate microbiome balance is via boosting skin’s own mechanisms of innate immunity, e.g. via boosting the activity of antimicrobial lipids or peptides.
  • amenable skin means the scalp which has dandruff.
  • Dandruff is a common scalp condition, characterized by excessive flaking and itch. It is generally accepted that the presence of dandruff is associated with changes in microbe ecology, altered lipid composition, inflammation and abnormal epidermal barrier function.
  • the Malassezia yeast has long been considered as one of the main microbial drivers for dandruff. Severity of dandruff is generally associated with an increased abundance of Malassezia restricta.
  • next generation sequencing NGS
  • qPCR quantitative polymerase chain reaction
  • the microbes are bacteria or fungi the bacteria or fungi is dandruff associated.
  • At least one genus of harmful microbes is Staphylococcus. It is further preferred that upon use of the present invention, total count of bacteria belonging to genus Staphylococcus is reduced to the level normally indicative of healthy skin. Such levels are within the domain knowledge of persons skilled in the art of cosmetics and pharmaceutical products.
  • the harmful microbe is Staphylococcus capitis. It is reported by Sally G. Grimshaw et al. that the major component of the fungal mycrobiome of both healthy and dandruff scalp is Malassezia restricta. The level of Malassezia restricta as quantified by qPCR is higher on dandruff scalp compared to healthy scalp, which is in consensus with the association of the yeast with dandruff condition. However, one of the other Malassezia species, namely Malassezia globosa, does not show the same trend as Malassezia restricta.
  • Malassezia dysbiosis index characterized by the ratio of Malassezia restricta / Malassezia globosa, indicated the association of disrupted Malassezia balance between the two species with dandruff conditions, that the Malassezia dysbiosis index is higher in dandruff conditions comparing with heathy.
  • ratio of Malassezia restricta / Malassezia globosa is reduced to the level normally indicative of healthy skin. Such levels are within the domain knowledge of persons skilled in the art of cosmetics and pharmaceutical products.
  • the use of zinc pyrithione or a piroctone compound in a topical composition balances microbiota of skin, where balancing means reducing the ratio of level of Malassezia restricta to that of Malassezia globosa, or selectively reducing microbial count of at least one genus of microbes belong to Staphylococcus. It is preferred that upon use of the present invention, the microbial count of at least one genus of microbes belong to commensal of skin, more preferably commensal of scalp is maintained. Preferably the commensal is Cutibacterium, more preferably Cutibacterium aeries.
  • such balancing is progressive, preferably takes at least 4 weeks.
  • the antimicrobial active is a piroctone compound, more preferably piroctone olamine.
  • Zinc pyrithione which is shorthand for zinc 1-hydroxy-2-pyridinethione is polyvalent metal salt of pyrithione.
  • the polyvalent metal salt of pyrithione is represented by the following general formula(l):
  • M is the metal cation zinc.
  • Piroctone Olamine is an olamine salt of the hydroxamic acid derivative piroctone. It is commonly known as piroctone ethanolamine with the trade name Octopirox ® .
  • the piroctone olamine according to the present invention is a 1:1 compound of 1- hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1 H)-pyridinone with 2-aminoethanol and is also designated 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H) pyridinone monoethanolamine salt.
  • the CAS number is 68890-66-4 and the compound has the general formula (II) as below:
  • the topical composition comprises 0.01 to 5.0 wt% of zinc pyrithione or a piroctone compound.
  • the composition preferably comprises a piroctone compound, more preferably piroctone olamine.
  • the composition preferably comprises 0.01 to 5%, more preferably 0.05 to 2%, still more preferably 0.5 to 1% of piroctone compound by weight of the total composition.
  • the topical composition comprises zinc pyrithione.
  • composition comprises zinc pyrithione it preferably comprises 0.01 to 5%, more preferably 0.02 to 3%, still more preferably 0.05 to 1% by weight of the composition.
  • the composition comprises zinc pyrithione and a piroctone compound. It is preferred that the piroctone compound is piroctone olamine.
  • the topical composition is a cosmetic composition.
  • the topical composition is a medicament or a pharmaceutical composition.
  • the cosmetic composition is preferably in the form of a wash-off or a leave-on composition, more preferably a wash-off composition.
  • a wash-off cosmetic composition more preferably a hair care composition comprising 0.01 to 5.0 wt% antimicrobial active selected from zinc pyrithione or a piroctone compound or a mixture thereof.
  • Leave-on composition preferably means a composition which is not required to be removed or washed off from the human body after the application of the composition.
  • the composition is preferably a deodorant (stick, roll-on or spray), a hand sanitizer, a body lotion, a skin cream or body spray.
  • Leave-on compositions are to be distinguished from compositions which are applied to the skin and subsequently removed, either by washing, rinsing, wiping, or the like either soon after or during the application of the product.
  • wash-off composition preferably means a composition which is intended/required to be removed from the body by washing with solvent preferably water after the application of said composition like e.g. a shampoo, a hand wash composition and a face wash composition.
  • solvent preferably water after the application of said composition like e.g. a shampoo, a hand wash composition and a face wash composition.
  • a cosmetically acceptable base preferably further comprises a surfactant.
  • the cosmetically acceptable base preferably comprises an anionic surfactant e.g. an alkyl sulphate and/or ethoxylated alkyl sulfate surfactant.
  • anionic surfactants are preferably present at a level of from 1 to 20 wt%, more preferably from 2 to 16 wt%, even more preferably from 3 to 16 wt%.
  • Preferred alkyl sulfates are C8 to 18 alkyl sulfates, more preferably C12 to 18 alkyl sulfates, preferably in the form of a salt with a solubilizing cation such as sodium, potassium, ammonium or substituted ammonium.
  • the topical composition comprises a cosmetically acceptable base.
  • ingredients that may be used as cosmetically acceptable base includes water, fatty acids, soaps (salts of fatty acids), alcohols and mixtures thereof.
  • composition for use in the invention is a hair care composition
  • it preferably is a wash-off composition, especially shampoo or a conditioner.
  • the preferred use of the cosmetic composition is in a shampoo.
  • the cosmetic composition may suitably comprise from 50 to 90%, preferably from 60 to 80% water by weight of the total shampoo composition.
  • Shampoo compositions for use in the invention will typically comprise one or anionic surfactants such as sodium laureth sulfate, sodium oleyl succinate, ammonium lauryl sulfosuccinate, ammonium lauryl sulphate, sodium dodecylbenzene sulphonate, triethanolamine dodecylbenzene sulfonate, sodium cocoyl isethionate, sodium lauryl isethionate, sodium N-lauryl sarcosinate, sodium lauryl sulfate, sodium lauryl ether sulfate (n) EO, (where n ranges from 1 to 3), ammonium lauryl sulfate and ammonium lauryl ether sulfate (n) EO, (where n ranges from 1 to 3) .
  • anionic surfactants such as sodium laureth sulfate, sodium oleyl succinate, ammonium lauryl sulfosuccinate,
  • the total amount of anionic surfactant in shampoo compositions for use in the invention generally ranges from 5 to 30%, preferably from 8 to 20% by weight of the total weight of the composition.
  • Shampoo compositions for use in the invention may also include co-surfactants such as nonionic surfactants, which can be included in an amount ranging from 0.5 to 8%, preferably from 2 to 5% (by weight based on the total weight of the composition) and/or amphoteric or zwitterionic surfactants, which can be included in an amount ranging from 0.5 to 8%, preferably from 1 to 4% by weight based on the total weight of the composition.
  • co-surfactants such as nonionic surfactants, which can be included in an amount ranging from 0.5 to 8%, preferably from 2 to 5% (by weight based on the total weight of the composition) and/or amphoteric or zwitterionic surfactants, which can be included in an amount ranging from 0.5 to 8%, preferably from 1 to 4% by weight based on
  • Nonionic surfactants include alkanolamides such as cocamide monoethanolamide and cocamide monoisopropanolamide; alkyl polyglucosides such as cocoglucoside and lauryl glucoside; and acyl glucamides such as cocoyl methyl glucamide.
  • Representive amphoteric surfactant includes cocamidopropyl betaine.
  • the shampoo composition for use in the invention comprises sodium laureth sulfate and co-surfactant which is cocamidopropyl betaine.
  • Shampoo compositions for use in the invention may also include one or more cationic polymers, which can be included in an amount ranging from 0.01 to 5%, preferably from 0.05 to 2% by weight based on the total weight of the composition.
  • Representative cationic polymers include cationic polysaccharide polymers such as cationic cellulose derivatives and cationic guar gum derivatives such as guar hydroxypropyltrimethylammonium chloride.
  • Shampoo compositions for use in the invention may also include one or more suspending agents, which can be included in an amount ranging from 0.05 to 5%, preferably from 0.1 to 3% (by weight based on the total weight of the composition).
  • suspending agents include polyacrylic acids, cross-linked polymers of acrylic acid, copolymers of acrylic acid with a hydrophobic monomer, copolymers of carboxylic acid-containing monomers and acrylic esters, cross-linked copolymers of acrylic acid and acrylate esters, heteropolysaccharide gums and crystalline long chain acyl derivatives such as ethylene glycol distearate.
  • the shampoo composition further preferably comprises a suspending agent.
  • Suitable suspending agents are polyacrylic acids, cross-linked polymers of acrylic acid, copolymers of acrylic acid with a hydrophobic monomer, copolymers of carboxylic acid- containing monomers and acrylic esters, cross-linked copolymers of acrylic acid and acrylate esters, heteropolysaccharide gums and crystalline long chain acyl derivatives.
  • the long chain acyl derivative is desirably selected from ethylene glycol stearate, alkanolamides of fatty acids having from 16 to 22 carbon atoms and mixtures thereof. Ethylene glycol distearate and polyethylene glycol distearate are preferred long chain acyl derivatives, since these impart pearlescence to the composition.
  • Polyacrylic acid is available commercially as Carbopol® 420, Carbopol® 488 or Carbopol® 493. Polymers of acrylic acid cross-linked with a polyfunctional agent may also be used; they are available commercially as Carbopol® 910, Carbopol® 934, Carbopol® 941 and Carbopol® 980.
  • Suitable cross-linked polymers of acrylic acid and acrylate esters are Pemulen® TR1 and Pemulen® TR2.
  • a suitable hetero polysaccharide gum is xanthan gum, for example that available as Kelzan.
  • the use of the cosmetic composition is in a skin care e.g. body or face wash composition.
  • the topical composition for use in the invention may further comprise a surfactant.
  • the preferred surfactants are nonionic surfactants.
  • the topical compositions include the surfactant selected from the group of anionic surfactants.
  • the topical composition for use in the invention preferably comprises 1 to 90% surfactant by weight of the composition.
  • a particularly preferred surfactant is soap.
  • Soap is a suitable surfactant for personal washing applications of the topical composition for use in the invention.
  • the soap, of the present is preferably present in an amount of 1 to 90%, preferably from 10 to 85%, more preferably 25 to 75% by weight of the composition.
  • Preferred compositions for use in the invention may include other known ingredients such as perfumes, pigments, preservatives, emollients, sunscreens, emulsifiers, gelling agents and thickening agents. Choice of these ingredients will largely depend on the format of the composition.
  • Water is a preferred carrier. When water is present, it is preferably present in at least 1%, more preferably at least 2%, furthermore preferably at least 5% by weight of the composition.
  • a preferred liquid composition comprises 10 to 99.8% by weight water.
  • the liquid topical composition is useful as a skin antiseptic liquid, for skin cleansing, in particular for hand wash or a face wash.
  • a preferred solid composition comprises 5 to 30% by weight water.
  • the solid topical composition for use in the invention is preferably in form of a shaped solid, more preferably a bar.
  • the solid topical composition for use in the invention is particularly useful for skin cleansing in particular for hand wash or a face wash.
  • inorganic particulate material is also a suitable carrier.
  • the topical composition for use in the invention is in a solid form.
  • the inorganic particulate material is talc.
  • the solid antimicrobial composition is particularly useful as a talcum powder for application on face or body.
  • the shampoo formulations are prepared as below in Table 1.
  • Table 1 a Commercial guar hydroxypropyltrimonium chloride has a DS of 0.16 to 0.20 and a weight average molecular weight from 1.0 to 1.5 million g/mol under the trade name
  • Microbial quantification Malassezia restricta, Malassezia globosa, C. acnes, S. capitis were quantified (copies/mL buffer) respectively by quantitative polymerase chain reaction (qPCR) method following the procedures as reported by Sally G. Gramshaw et al. from pellet of scalp buffer scrub samples.
  • qPCR quantitative polymerase chain reaction
  • Table 2 The data in Table-2 indicates that for the dandruff subjects, after 4 weeks of shampoo wash, Shampoo 1 (with Octopirox ® ) has significantly lower (p ⁇ 0.001) ratio of
  • Cutibacterium acnes is the most abundant bacteria species on scalp, which is a scalp commensal whose absolute level is not altered in dandruff scalp comparing with healthy scalp.
  • the quantity of Cutibacterium acnes was tested after treating with different shampoo samples and is summarized in Table 4.
  • Example 2 These examples are to explore the effect of a prototype shampoo with zinc pyrithione on scalp microbiome versus a placebo shampoo (without anti-dandruff actives), through investigation of both scalp fungal communities.
  • the shampoo formulations are prepared as below in Table 5.
  • Table 5 a Commercial guar hydroxypropyltrimonium chloride has a DS of 0.16 to 0.20 and a weight average molecular weight from 1.0 to 1.5 million g/mol under the trade name BB-18 from Lamberti.
  • a clinical study was conducted on a group of subjects who were classified as suffering with dandruff were treated for 4 weeks with a shampoo 2 containing zinc pyrithione comparing with a placebo shampoo B without zinc pyrithione.
  • Malassezia restricta and Malassezia globosa were quantified (copies/mL buffer) respectively by quantitative polymerase chain reaction (qPCR) method following the procedures as reported by Sally G. Gramshaw et al. from pellet of scalp buffer scrub samples. The ratio of Malassezia restricta / Malassezia globosa was tested after treating with different shampoo samples and is summarized in Table 6.

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Abstract

La présente invention concerne l'utilisation de pyrithione de zinc ou d'un composé de piroctone dans une composition topique pour équilibrer le microbiote de la peau, le moyen d'équilibrage réduisant le rapport de niveau de Malassezia restricta à celui de Malassezia globosa, ou réduisant sélectivement le nombre microbien d'au moins un genre de microbes appartienant à Staphylococcus ; ladite peau étant un cuir chevelu ayant des pellicules ; ledit genre de microbes appartenant à Staphylococcus étant le Staphylococcus capitis.
PCT/EP2022/064511 2021-06-09 2022-05-30 Composition topique pour l'équilibrage du microbiote de la peau WO2022258405A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN2021099236 2021-06-09
CNPCT/CN2021/099236 2021-06-09
EP21187098.5 2021-07-22
EP21187098 2021-07-22

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WO2022258405A1 true WO2022258405A1 (fr) 2022-12-15

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10265408A (ja) * 1997-03-25 1998-10-06 Lion Corp 殺菌剤組成物
WO2013093823A2 (fr) * 2011-12-20 2013-06-27 Vyome Biosciences Pvt Ltd Compositions d'huile à usage topique pour le traitement des infections fongiques
WO2018050056A1 (fr) * 2016-09-13 2018-03-22 The Procter & Gamble Company Méthodes d'augmentation de la diversité microbienne d'un microbiote cutané
EP3695825A1 (fr) * 2019-02-15 2020-08-19 Unilever PLC Composition de soins capillaires
US20200289525A1 (en) * 2019-03-13 2020-09-17 The Procter & Gamble Company Methods of Increasing Microbial Diversity of a Skin Microbiota

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10265408A (ja) * 1997-03-25 1998-10-06 Lion Corp 殺菌剤組成物
WO2013093823A2 (fr) * 2011-12-20 2013-06-27 Vyome Biosciences Pvt Ltd Compositions d'huile à usage topique pour le traitement des infections fongiques
WO2018050056A1 (fr) * 2016-09-13 2018-03-22 The Procter & Gamble Company Méthodes d'augmentation de la diversité microbienne d'un microbiote cutané
EP3695825A1 (fr) * 2019-02-15 2020-08-19 Unilever PLC Composition de soins capillaires
US20200289525A1 (en) * 2019-03-13 2020-09-17 The Procter & Gamble Company Methods of Increasing Microbial Diversity of a Skin Microbiota

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"Effectiveness of a rebalancing shampoo (RD10890) as a relay treatment for dandruff: Clinical, instrumental, and biochemical comparative study ED - Lim Henry W", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, MOSBY, INC, US, vol. 79, no. 3, 2 August 2018 (2018-08-02), XP085434632, ISSN: 0190-9622, DOI: 10.1016/J.JAAD.2018.05.496 *
CAS, no. 68890-66-4
DATABASE GNPD [online] MINTEL; 30 May 2006 (2006-05-30), ANONYMOUS: "Anti-Dandruff Treatment", XP055874533, retrieved from https://www.gnpd.com/sinatra/recordpage/537512/ Database accession no. 537512 *
SAAD M ET AL: "Molecular Epidemiology ofandin Sudanese Patients with Pityriasis Versicolor", MYCOPATHOLOGIA, KLUWER ACADEMIC PUBLISHERS, DO, vol. 175, no. 1 - 2, 4 October 2012 (2012-10-04), pages 69 - 74, XP035169826, ISSN: 1573-0832, DOI: 10.1007/S11046-012-9587-Y *

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