WO2022241968A1 - Huile essentielle de plantes pour la prévention et le traitement de la coccidiose et son utilisation - Google Patents

Huile essentielle de plantes pour la prévention et le traitement de la coccidiose et son utilisation Download PDF

Info

Publication number
WO2022241968A1
WO2022241968A1 PCT/CN2021/114808 CN2021114808W WO2022241968A1 WO 2022241968 A1 WO2022241968 A1 WO 2022241968A1 CN 2021114808 W CN2021114808 W CN 2021114808W WO 2022241968 A1 WO2022241968 A1 WO 2022241968A1
Authority
WO
WIPO (PCT)
Prior art keywords
essential oil
plant essential
coccidiosis
parts
feed
Prior art date
Application number
PCT/CN2021/114808
Other languages
English (en)
Chinese (zh)
Inventor
汪德中
林宜生
张祺满
Original Assignee
广东瑞生科技集团有限公司
汪德中
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 广东瑞生科技集团有限公司, 汪德中 filed Critical 广东瑞生科技集团有限公司
Publication of WO2022241968A1 publication Critical patent/WO2022241968A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/20—Animal feeding-stuffs from material of animal origin
    • A23K10/22—Animal feeding-stuffs from material of animal origin from fish
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/20—Animal feeding-stuffs from material of animal origin
    • A23K10/26—Animal feeding-stuffs from material of animal origin from waste material, e.g. feathers, bones or skin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
    • A23K10/38—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material from distillers' or brewers' waste
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/105—Aliphatic or alicyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/111—Aromatic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/174—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/22—Compounds of alkali metals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/30—Oligoelements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K30/00—Processes specially adapted for preservation of materials in order to produce animal feeding-stuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/532—Agastache, e.g. giant hyssop
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
    • Y02P60/87—Re-use of by-products of food processing for fodder production

Definitions

  • the invention relates to the field of plant essential oils, in particular to a plant essential oil for controlling coccidia and its application.
  • Coccidiosis is an intestinal parasitic disease of animals caused by protozoa called coccidia.
  • Coccidiosis is a high-incidence disease in the breeding process of animal husbandry, and the harm caused to animal husbandry is very serious, including the livestock breeding of pigs, cattle, chickens, rabbits and other livestock and poultry, such as: in the breeding process of pigs, piglets are prone to Infection with coccidia can cause digestive tract diseases, diarrhea, emaciation and growth retardation; in the process of cattle breeding, after cattle are infected with coccidia, it will hinder nutrient absorption, resulting in slow growth or decreased milk production, and in severe cases, it can also cause Diarrhea, blood in the stool or even death; in the process of chicken breeding, the morbidity and mortality rate of younger chickens can be as high as 80%, and the growth of the sick chicks is hindered and the weight gain is slow.
  • antibiotics for the prevention and treatment of coccidiosis in livestock and poultry mainly including sulfonamide antibiotics and polyether ionophore antibiotics, such as sulfamethoxine (SMM), sulfamethoxine Mouthazole (SMZ) plus trimethoprim (TMP), monensin, salinomycin;
  • SMM sulfamethoxine
  • SZ sulfamethoxine Mouthazole
  • TMP trimethoprim
  • monensin salinomycin
  • the present invention aims to overcome at least one deficiency of the above-mentioned prior art, and provides a plant essential oil for controlling coccidia, which can achieve effective anti-coccidia through the combined use of components from various natural ingredients, and the ingredients are natural and safe High, no withdrawal period, can overcome the existing problems of antibiotic residues and bacterial resistance.
  • the combination of multiple components can not only effectively control coccidiosis synergistically, but also help to improve palatability, promote the consumption of livestock and poultry, and shorten the anti-coccidian cycle.
  • a kind of plant essential oil for preventing and controlling coccidiosis comprises the following components in parts by weight:
  • cinnamaldehyde not only has antiseptic, bactericidal and anti-toxic effects, but also promotes gastrointestinal motility, enhances digestive function, and increases livestock and poultry food intake; and cinnamaldehyde itself can improve the taste of feed, improve palatability, and its unique fragrance can also help increase the desire to eat , to promote livestock and poultry feed.
  • thymol also has antibacterial and anti-inflammatory functions, and it has positive effects on growth performance and intestinal flora after being added to feed.
  • Eugenol itself also has certain antibacterial, anti-inflammatory, anti-parasitic and other effects.
  • Carvacrol has antibacterial and antioxidative effects, can prevent and treat the infection in the gastrointestinal tract of animals, and also has a certain preventive effect on coccidia; in addition, the antioxidative effect of carvacrol can also prolong the shelf life of feed and prevent feed deterioration.
  • Food paraffin oil not only helps to disperse the essential oil components evenly, but also helps to combine with the essential oil part to reduce the volatilization of the essential oil part and prolong the drug effect. Furthermore, food paraffin oil can also cooperate with essential oil components such as cinnamaldehyde to play a positive role in the intestinal tract.
  • the traditional Chinese medicine extracts are one or more of cloves, cinnamon, coptis, and Huoxiang.
  • the extract of traditional Chinese medicine is 18-23 parts.
  • the traditional Chinese medicine extract contains cloves, cinnamon, coptis, and Huoxiang in a ratio of 1:1:1:1.
  • the cloves, cinnamon, coptis, and wrinkled ager all have antibacterial and anthelmintic effects, can directly act on germs and coccidia, can also promote gastrointestinal digestion, increase feeding amount, and are beneficial to achieve synergy based on themselves and other essential oil components.
  • Significant anti-coccidial effect shorten the cycle of anti-coccidial.
  • this type of traditional Chinese medicine extract can improve immunity and further prevent and treat diseases.
  • this type of traditional Chinese medicine extract can also promote the growth of livestock and poultry, shorten the time for slaughter, and is conducive to efficient production in the process of livestock breeding.
  • anti-mildew antioxidant contains one or more of citric acid, sodium benzoate and BHT, and the anti-caking adsorbent Contains silicon dioxide, sodium chloride.
  • the anti-mildew antioxidant is 3.5-8 parts, and the anti-caking adsorbent is 65-77 parts.
  • the citric acid, sodium benzoate, and BHT are respectively 3% citric acid, 1% sodium benzoate, and 1% BHT.
  • Another object of the present invention is to provide the use of plant essential oils for preventing and controlling coccidiosis in the preparation of anticoccidial feed additives, anticoccidial drugs and/or drugs for treating livestock and poultry coccidiosis.
  • the plant essential oil in this application can effectively resist coccidia, and the source of main components is natural, with high safety, which can effectively improve the feed intake of livestock and poultry and shorten the period of anti-coccidia, and shorten the time for slaughtering, which is beneficial to be used in anti-coccidia feed additives, Anticoccidial drugs and/or drugs for the treatment of coccidiosis in livestock and poultry to achieve the corresponding anti-coccidiosis and feeding effects.
  • Another object of the present invention is to provide an anti-coccidial feed, which contains feed raw materials and the above-mentioned plant essential oil for controlling coccidia.
  • the feed material includes corn, bran, soybean meal, bone meal, fish meal, flax meal, cottonseed meal, alfalfa, palm meal, silage, calcium bicarbonate, methionine, NaCl, trace elements, vitamins, water, sweet potato seedling powder , corn bellflower powder, soybean cake, distiller's grains, rice bran meal, inorganic salts, and one or more ingredients in amino acid additives.
  • the plant essential oil content in the anticoccidial feed is 200mg-600mg/1kg.
  • a further object of the present invention is to provide the use of the eucalyptus extract with a sanguinarine content of 0.8-1.3% in the preparation of anticoccidial feed additives, anticoccidial drugs and/or drugs for treating livestock and poultry coccidiosis.
  • the Boluohui extract containing a specific content of sanguinarine can also be used in anticoccidial feed additives, anticoccidial drugs and/or drugs for the treatment of livestock and poultry coccidiosis, so as to achieve the corresponding anticoccidial effect.
  • the beneficial effects of the present invention are as follows: in this application, the combination of essential oil components and Boluohui extract containing a specific content of sanguinarine can achieve effective anti-coccidian feed adding plant essential oils.
  • the main anticoccidial components of plant essential oils come from natural sources, have high safety, and can effectively avoid the problems of antibiotic residues and bacterial resistance in the prior art. High safety, natural source of main ingredients, low toxicity and side effects, no need to stop the drug during use, which is beneficial to shorten the anti-coccidian cycle.
  • the plant essential oils of this application can also synergistically improve the palatability and promote feeding of livestock and poultry, so that livestock and poultry can always maintain an effective intake of plant essential oils and maintain a relatively stable anti-inflammatory effect.
  • the coccidiosis process significantly improves the anti-coccidial effect.
  • further adding food paraffin oil is more conducive to reducing the volatilization of essential oil components and prolonging their efficacy time.
  • this application also adds traditional Chinese medicine extracts, and the feed formed by compatibility with plant essential oils has the effects of promoting digestion and promoting growth. production process.
  • the present application also further enhances the anti-mold and anti-oxidation ability of the plant essential oil components that already have anti-corrosion and anti-mold effects by adding anti-mold and anti-oxidants, prolonging the shelf life of the plant essential oils, which is beneficial to the application in the actual animal husbandry industry.
  • the plant essential oil has a good dispersion state, and it can be dispersed evenly after being added to the feed, so as to ensure that livestock and poultry can steadily and continuously eat the effective amount of plant essential oil, and promote the anti-coccidial effect.
  • the plant essential oil of this application has natural main components, can effectively resist coccidia, and has a stable, safe and efficient effect.
  • Fig. 1 is embodiment 22 plant essential oil anti-chicken coccidiosis test index.
  • component A (1) Mix cinnamaldehyde, thymol, eugenol, carvacrol, peppermint oil, and eucalyptus oil according to the required ratio to obtain component A; when food-grade paraffin oil is added, then according to the required ratio Component A is mixed with food-grade paraffin oil through a homogenizer to obtain component A1.
  • the Boluohui extract is obtained after crushing and sieving Boluohui; specifically, the Boluohui extract is mixed with A component/A1 component by spraying, or B component and A Components/Component A1 are mixed by spraying.
  • the formula dosage is set according to the proportion, such as: the formula components are 50g cinnamaldehyde, 20g thymol, 15g eugenol, 8g carvacrol, 1g peppermint oil, 60g eucalyptus oil, 160g Boluohui extract (San represents sanguinarine, the content of sanguinarine is 0.8%).
  • the preparation process of embodiment 1 feed adding plant essential oil is then: 50g cinnamaldehyde, 20g thymol, 15g eugenol, 8g carvacrol, 1g peppermint oil, 60g eucalyptus oil are mixed, obtain A component; Then 160g The Boluohui extract (0.8% of sanguinarine content) is mixed with the obtained component A to obtain plant essential oil added to the corresponding feed.
  • the formula dosage is set according to the proportion, such as: the formula components are 85g food paraffin oil, 85g cinnamaldehyde, 40g thymol, 8g eugenol, 13g carvacrol, 5g peppermint oil, 60g eucalyptus oil, 200g Boluohui extract (sanguinarine content 1.1%), 2kg Chinese medicine extract, 500g anti-mildew antioxidant, 7kg anti-caking adsorbent.
  • the formula components are 85g food paraffin oil, 85g cinnamaldehyde, 40g thymol, 8g eugenol, 13g carvacrol, 5g peppermint oil, 60g eucalyptus oil, 200g Boluohui extract (sanguinarine content 1.1%), 2kg Chinese medicine extract, 500g anti-mildew antioxidant, 7kg anti-caking adsorbent.
  • Example 11 The preparation process of adding plant essential oils to feed is as follows: 85g cinnamaldehyde, 40g thymol, 12g eugenol, 13g carvacrol, 5g peppermint oil, and 30g eucalyptus oil are mixed to obtain component A; Component and 85g food paraffin oil are mixed by a homogenizer, the homogenizer rotating speed is 23000r/min, and the homogenization time is 15min to obtain the A1 component; 200g Boluohui extract and 2kg Chinese medicine extract (except examples 15-18 , including clove in the Chinese medicine extract of embodiment 11: cinnamon: Coptidis Rhizoma: Patchouli are 1: 1: 1: 1), 500g anti-mildew antioxidant (except embodiment 19 ⁇ 21, other embodiment anti-mold antioxidant Medium citric acid: sodium benzoate, BHT are both 1:1:1), 7kg anti-caking adsorbent (under the premise of not indicating, the following examples all adopt silicon dioxide: sodium chloride is a ratio of
  • Example 1 The above preparation process was used to prepare according to the formula ratio in Table 1, and the corresponding feed of Example 1 was added with plant essential oil.
  • Example 2 The above preparation process was used to prepare according to the formula ratio in Table 1, and the corresponding feed of Example 2 was added with plant essential oil.
  • Example 3 The above preparation process was used to prepare according to the formula ratio in Table 1, and the corresponding feed of Example 3 was added with plant essential oil.
  • Example 4 The above preparation process was used to prepare according to the formula ratio in Table 1, and the corresponding feed of Example 4 was added with plant essential oil.
  • Example 5 The above preparation process was used to prepare according to the formula ratio in Table 1, and the corresponding feed of Example 5 was added with plant essential oil.
  • Example 6 The above preparation process was used to prepare according to the formula ratio in Table 2, and the corresponding feed of Example 6 was added with plant essential oil.
  • Example 7 The above preparation process was used to prepare according to the formula ratio in Table 2, and the corresponding feed of Example 7 was added with plant essential oil.
  • Example 8 The above preparation process was used to prepare according to the formula ratio in Table 2, and the corresponding feed of Example 8 was added with plant essential oil.
  • Example 9 The above preparation process was used to prepare according to the formula ratio in Table 2, and the corresponding feed of Example 9 was added with plant essential oil.
  • Example 10 The above preparation process was used to prepare according to the formula ratio in Table 2, and the corresponding feed of Example 10 was added with plant essential oil.
  • Example 11 was added with plant essential oil.
  • Example 12 The above preparation process was used to prepare according to the formula ratio in Table 2, and the corresponding feed of Example 12 was added with plant essential oil.
  • Example 13 The above preparation process was used to prepare according to the formula ratio in Table 2, and the corresponding feed of Example 13 was added with plant essential oil.
  • Example 14 was added with plant essential oil.
  • Example 15 was added with plant essential oil.
  • Example 16 was added with plant essential oil.
  • Example 17 was added with plant essential oil.
  • Example 18 was added with plant essential oil.
  • Example 19 was added with plant essential oil.
  • Example 20 was added with plant essential oil.
  • Example 21 was added with plant essential oil.
  • Each embodiment allocates 100 1-day-old white-feathered broiler chickens, and each embodiment adds plant essential oil to the feed of the corresponding group according to the amount of 400 mg/kg added to the basal diet.
  • the Eimeria tenella of inoculation sporulation After feeding 10d by each embodiment group group, the Eimeria tenella of inoculation sporulation, the average number of infection is identical; After infecting, each group of test chickens is sampled and tested every day, for embodiments 1 to 14, comparative example 1 ⁇ 4. After the test, record the weight gain rate, survival rate, bloody feces score (refer to Morehouse method, 1970), lesion score (refer to Johnson method, 1970), detect the anti-coccidiostat index, and the reduction of coccidia is the original infected individual.
  • the anti-coccidiosis time at half count the average daily feed amount from the beginning of feeding to the end of the final experiment, whether there was anorexia to the feed at the beginning of feeding, the amount of plant essential oil after the indoor feed was left standing for 3 days, and the starting point of feeding On the 5th day, the residual plant essential oil components in livestock and poultry manure, the performance of anti-mold, anti-oxidation and anti-caking performance during feed storage.
  • the anti-coccidial index (relative weight gain rate+survival rate)-(lesion value+oocyst value), if the anti-coccidiostat index is above 180, it is judged that the effect of controlling coccidiosis in chickens is satisfactory, when it is between 160-180 It is judged as relatively satisfactory, between 120-160 is judged as difficult to control, and below 120 is judged as uncontrollable.
  • control group 1 negative control group
  • control group 2 positive control group
  • the control group 1 is not inoculated with coccidia, and is fed with feed that does not add feed and adds plant essential oils.
  • the control group Group 2 was fed for 10 days with the feed without adding plant essential oils, inoculated with the same number of coccidia as in Examples 1-14, and continued to feed until the same day as other examples for testing.
  • the daily feeding amount of Examples 1-14 and Comparative Examples 1-4 is based on the daily feeding amount of the control group 1, with + number representing the degree of increase and - number representing the degree of decrease.
  • Anorexia is based on the average food intake in the initial 2 days and the average time from the feeding to the start of eating as a benchmark for each embodiment, and the corresponding data of the control group 1 is used as a benchmark.
  • the amount of plant essential oil after the same amount of feed is left standing for 3 days is measured after the feed opening is placed indoors for 3 days, and compared with the initial 400mg/kg ratio as a benchmark, the number of "-" indicates the amount of reduction, "-" More indicates that the remaining plant essential oil is less, so as to detect whether the plant essential oil in the feed is volatile.
  • the residual plant essential oil in livestock and poultry feces on the 5th day is to detect whether the livestock and poultry have fully absorbed and digested the feed and added plant essential oil, and "+" indicates the residual degree between groups, and the more "+” indicates the more residual.
  • Anti-mold and anti-oxidation means to regularly check whether there is any sign of mold after the feed is left empty in the room, and judge the corresponding anti-mold and anti-oxidation effect by observing the number of days required for mold.
  • the anti-caking is to regularly check whether there is agglomeration after the feed is left empty in the room. The test results are as follows:
  • the storage period can be extended by adding anti-mildew antioxidants, and the addition of anti-caking adsorbent is conducive to keeping the feed in a loose state for a long time, which is helpful for livestock and poultry to eat, digest and absorb.
  • Examples 6-14 significantly shorten the anti-coccidial time, which is beneficial to promote the normal progress of breeding, and inhibit coccidia as early as possible to make the normal development and growth of livestock and poultry.
  • the addition of food-grade paraffin oil is at least beneficial to the digestion and absorption of feed, and prolongs the retention time of essential oils.
  • the Chinese medicine extract contains one or more types, which can effectively promote the anticoccidial effect, and when it contains cloves, cinnamon, coptis, and Huoxiang The effect is better.
  • the anti-mold antioxidants contain one or more types of anti-mold and antioxidant effects, and contain citric acid, sodium benzoate, and BHT at the same time. The effect is better.
  • the plant essential oil in this example was added with the corresponding feed of Example 1, the coccidiosis vaccine was a chicken coccidiosis quadrivalent live vaccine, and the chemical drug control group was sulfachlorpyrazine sodium.
  • the poultry group (white control) not infected with coccidia, the infected poultry group (red control) without taking anti-coccidia measures, the infected poultry group (vaccine group) vaccinated, and the administration of chemical drug sulfaclopyr were respectively set up.
  • Infected poultry group (chemical drug control group) of Vietnamesene sodium, infected poultry group administered with garlic alone, infected poultry group jointly administered with garlic and 250 mg plant essential oil, infected poultry group jointly administered with garlic and 500 mg plant essential oil, administered alone 250 mg plant essential oil
  • the infected poultry group and the infected poultry group administered with 500 mg plant essential oil alone were tested against coccidiosis, and the anticoccidial effect of each group was judged by the final anticoccidial index score.
  • the poultry in this embodiment is chicken, and the results of the anticoccidial index scores are shown in FIG. 1 .
  • the animals were fed at the age of 12 days, coccidia were inoculated at the age of 16 days, and the anti-coccidial index was calculated at the age of 24 days.
  • the anticoccidial index obtained by different dosage groups of plant essential oils is between 120 and 160, indicating that the plant essential oils of the present application can effectively resist coccidia.
  • the effect of using plant essential oil 250mg/kg feed compatibility alone is the best, and the ACI is 150 (and the difference between its ACI and Examples 1 to 21 may be due to the difference in the growth day age of the poultry, the difference in the inoculation day age and the resistance to the disease. Coccidia are caused by a shorter age).
  • the plant essential oil in the present application has a natural source, and is safer than chemical anticoccidial drugs, and can overcome the problems of existing chemical anticoccidial drug residues and affecting human health.
  • the present embodiment carries out the anti-Eimeria maxima experiment, setting up the negative control group that is not infected with coccidia, the positive control group that is infected with coccidia and does not give anti-coccidia measures, and applies Fulanbao to infected poultry
  • the Micro-Aid group of Micro-Aid the plant essential oil group in which the corresponding feed of Example 1 was added to infected poultry, and the monoglyceride group in which monoglyceride (6-12C medium-chain fatty acid) was administered to infected poultry.
  • the plant essential oil of Example 1 of the present application can effectively resist coccidia.
  • the plant essential oil group has significantly reduced the number of feces oocysts per gram, and has obvious anti-coccidial effect, and In addition to Eimeria tenella, it is also effective against Eimeria giga.
  • the poultry in the plant essential oil group did not experience weight loss or slow weight gain. Even under the premise that the initial average body weight was low, after applying plant essential oil for many days, the average body weight of the group exceeded other poultry infected with coccidia and administered the drug. group.
  • the plant essential oil of the present application also has its outstanding anticoccidial effect and safety, and is beneficial to put into animal husbandry production to promote production.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Physiology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Fodder In General (AREA)

Abstract

Huile essentielle de plantes pour la prévention et le traitement de la coccidiose, comprenant les composants suivants en parties en poids : de 0,5 à 1,3 partie de cinnamaldéhyde ; de 0,2 à 0,7 partie de thymol ; de 0,08 à 0,3 partie de syringol ; de 0,08 à 0,3 partie de carvacrol ; de 0,01 à 0,1 partie d'huile de menthe poivrée ; de 0,3 à 1 partie d'huile d'eucalyptus ; et de 1,6 à 2,5 parties d'extrait de Macleaya cordata, la teneur en sanguinarine de l'extrait de Macleaya cordata étant de 0,8 à 1,3 %. L'huile essentielle de plantes peut également comprendre de 0,5 à 1,3 partie d'huile de paraffine de qualité alimentaire ; de 15 à 25 parties d'un extrait issu de la médecine chinoise traditionnelle, l'extrait issu de la médecine chinoise traditionnelle étant un ou plusieurs composants parmi le clou de girofle, la cannelle, le Coptis chinensis et l'Agastache rugosus; de 1 à 10 parties d'antioxydant antimoisissure ; et de 60 à 85 parties d'adsorbant antiagglomération ; l'antioxydant antimoisissure comprenant un ou plusieurs composants parmi l'acide citrique, le benzoate de sodium et le BHT, et l'adsorbant antiagglomération comprenant du dioxyde de silicium et du chlorure de sodium. Ladite huile essentielle de plantes pour la prévention et le traitement de la coccidiose peut être utilisée pour la préparation d'un additif alimentaire contre la coccidiose, d'un médicament contre la coccidiose et/ou d'un médicament pour le traitement de la coccidiose chez les volailles et le bétail. L'invention concerne également une utilisation de l'extrait de Macleaya cordata, dont la teneur en sanguinarine est de 0,8 à 1,3 %, dans la préparation d'additifs alimentaires contre la coccidiose, d'un médicament contre la coccidiose et/ou d'un médicament pour le traitement de la coccidiose chez les volailles et le bétail.
PCT/CN2021/114808 2021-05-17 2021-08-26 Huile essentielle de plantes pour la prévention et le traitement de la coccidiose et son utilisation WO2022241968A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202110536249.4 2021-05-17
CN202110536249.4A CN113134031A (zh) 2021-05-17 2021-05-17 一种防治球虫的植物精油及其用途

Publications (1)

Publication Number Publication Date
WO2022241968A1 true WO2022241968A1 (fr) 2022-11-24

Family

ID=76817262

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2021/114808 WO2022241968A1 (fr) 2021-05-17 2021-08-26 Huile essentielle de plantes pour la prévention et le traitement de la coccidiose et son utilisation

Country Status (2)

Country Link
CN (1) CN113134031A (fr)
WO (1) WO2022241968A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113134031A (zh) * 2021-05-17 2021-07-20 广东瑞生科技集团有限公司 一种防治球虫的植物精油及其用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101530475A (zh) * 2009-04-17 2009-09-16 湖南美可达生物资源有限公司 博落回提取物在经济动物兽药中的应用
CN105475666A (zh) * 2015-12-07 2016-04-13 山川生物科技(武汉)有限公司 一种防治鸡球虫病的饲料添加剂制备方法
CN110201035A (zh) * 2019-06-21 2019-09-06 刘春海 一种禽用植物精油组合物及其制备方法和应用
CN111513211A (zh) * 2020-06-01 2020-08-11 广州市天朝生物科技有限公司 一种用于畜禽与水产养殖的水溶性营养精油及其制备方法和应用
CN113134031A (zh) * 2021-05-17 2021-07-20 广东瑞生科技集团有限公司 一种防治球虫的植物精油及其用途

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101530475A (zh) * 2009-04-17 2009-09-16 湖南美可达生物资源有限公司 博落回提取物在经济动物兽药中的应用
CN105475666A (zh) * 2015-12-07 2016-04-13 山川生物科技(武汉)有限公司 一种防治鸡球虫病的饲料添加剂制备方法
CN110201035A (zh) * 2019-06-21 2019-09-06 刘春海 一种禽用植物精油组合物及其制备方法和应用
CN111513211A (zh) * 2020-06-01 2020-08-11 广州市天朝生物科技有限公司 一种用于畜禽与水产养殖的水溶性营养精油及其制备方法和应用
CN113134031A (zh) * 2021-05-17 2021-07-20 广东瑞生科技集团有限公司 一种防治球虫的植物精油及其用途

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DENG, DUN, DENG, YUELIN: "Research Progress in Macleaya cordata", JOURNAL OF DOMESTIC ANIMAL ECOLOGY, vol. 30, no. 4, 1 July 2009 (2009-07-01), pages 1 - 3, XP093006752 *
HUANG JINYU, HE QIANG, WANG HONGYU, SONG YIZHEN, CHEN JIE, SONG ZHIGANG: "Application of Feed Additives in Control of Chicken Coccidiosis", CHINA POULTRY - ZHONGGUO JIAGIN, JIANG SU SHENG YANG ZHOU SHI, CN, vol. 40, no. 14, 1 January 2018 (2018-01-01), CN , pages 41 - 44, XP093006742, ISSN: 1004-6364, DOI: 10.16372/j.issn.1004-6364.2018.14.009 *
XUE G.D., WU S.B., CHOCT M., PASTOR A., STEINER T., SWICK R.A.: "Impact of a Macleaya cordata-derived alkaloid extract on necrotic enteritis in broilers", POULTRY SCIENCE, OXFORD UNIVERSITY PRESS, OXFORD, vol. 96, no. 10, 1 October 2017 (2017-10-01), Oxford , pages 3581 - 3585, XP093006745, ISSN: 0032-5791, DOI: 10.3382/ps/pex164 *

Also Published As

Publication number Publication date
CN113134031A (zh) 2021-07-20

Similar Documents

Publication Publication Date Title
Ajiboye et al. A perspective on the ingestion and nutritional effects of feed additives in farmed fish species
JP4790129B2 (ja) カルバクロールおよびチモールを含む組成物の、トレポネーマによってもたらされる疾患の治療のための薬剤の製造のための使用
KR101865525B1 (ko) 반추 동물의 유량 및/또는 유질 향상제, 주산기병 예방 또는 치료제, 그리고 번식 효율 개선제
Aguilar et al. Effect of dietary supplementation with Anacardium occidentale on growth performance and immune and visceral organ weights in replacement laying pullets
Youssef et al. Effects of dietary inclusion of probiotics and organic acids on performance, intestinal microbiology, serum biochemistry and carcass traits of broiler chickens
CN110786424A (zh) 厚朴酚和/或和厚朴酚在家禽养殖中的应用
CN110692863A (zh) 一种提高罗非鱼保肝护肠能力的植物提取物饲料添加剂
CN104543410B (zh) 一种保健抗病猪饲料添加剂及其制备方法
Ali et al. Effects of turmeric powder on Clostridium perfringens load in broiler chickens.
WO2022241968A1 (fr) Huile essentielle de plantes pour la prévention et le traitement de la coccidiose et son utilisation
CN103931931A (zh) 一种预防鸡的曲霉菌病的饲料添加剂
Duvvu et al. Effect of garli c supplementation on the growth performance and body condition score in Murrah buffalo calves
KR0143954B1 (ko) 동물의 번식력 및 증체량 증진용 조성물 및 이를 함유하는 제제
CN108651709A (zh) 抗菌抑菌促生长剂及其制备方法和用途
CN107811128B (zh) 一种可调节仔猪肠道菌群的饲料添加剂
Dieumou et al. Effect of supplemented diets with garlic organic extract and streptomycin sulphate on intestinal microflora and nutrients digestibility in broilers
Jarupan et al. Effect of colistin and liquid methionine with capsaicin supplementation in diets on growth performance and intestinal morphology of nursery pigs
Ceylan et al. Comparative effects of medium‐chain fatty acids or phytobiotics‐based feed additives on performance, caecum microbiota, volatile fatty acid production and intestinal morphology of broilers
CN110214858A (zh) 团头鲂抗应激膨化饲料及其制备方法
CN110755604A (zh) 一种防治家禽腺肌胃炎的药物组合物及其应用
Živković et al. Garlic as alternative for antibiotics in diet for growing pigs
CN112716942B (zh) 吲哚及包含其的鸭饲料用于维持鸭肠道健康和/或预防鸭坏死性肠炎的用途
CN110025774B (zh) 防治新生仔猪下痢膏及生产方法
JPS63238020A (ja) 対飼育動物投与用バチルス・ポリミキサ含有剤
CN107494922A (zh) 一种用于调节肠道的微生态中药饲料添加剂及其制备方法

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21940417

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 21940417

Country of ref document: EP

Kind code of ref document: A1