WO2022233937A3 - Dosierkopf und fluidiksystem zur aufnahme und dosierung wenigstens eines mediums - Google Patents

Dosierkopf und fluidiksystem zur aufnahme und dosierung wenigstens eines mediums Download PDF

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Publication number
WO2022233937A3
WO2022233937A3 PCT/EP2022/061985 EP2022061985W WO2022233937A3 WO 2022233937 A3 WO2022233937 A3 WO 2022233937A3 EP 2022061985 W EP2022061985 W EP 2022061985W WO 2022233937 A3 WO2022233937 A3 WO 2022233937A3
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WO
WIPO (PCT)
Prior art keywords
metering
medium
metering head
receiving
head
Prior art date
Application number
PCT/EP2022/061985
Other languages
English (en)
French (fr)
Other versions
WO2022233937A2 (de
Inventor
Christian FREESE
Peter Spang
Original Assignee
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V. filed Critical Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V.
Priority to EP22727838.9A priority Critical patent/EP4334036A2/de
Publication of WO2022233937A2 publication Critical patent/WO2022233937A2/de
Publication of WO2022233937A3 publication Critical patent/WO2022233937A3/de

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0203—Burettes, i.e. for withdrawing and redistributing liquids through different conduits
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/023—Adapting objects or devices to another adapted for different sizes of tubes, tips or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1894—Cooling means; Cryo cooling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B01L3/0279—Interchangeable or disposable dispensing tips co-operating with positive ejection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/103—General features of the devices using disposable tips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1048—General features of the devices using the transfer device for another function
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1048—General features of the devices using the transfer device for another function
    • G01N2035/1058—General features of the devices using the transfer device for another function for mixing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1048—General features of the devices using the transfer device for another function
    • G01N2035/1062—General features of the devices using the transfer device for another function for testing the liquid while it is in the transfer device

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

Die Erfindung betrifft einen Dosierkopf (110, 710, 910, 1010,1110) zur Aufnahme und Dosierung wenigstens eines Mediums, welcher einen oder mehrere Medienzugänge (112, 712, 912, 1012, 1112), wenigstens zwei Ausgabeterminals (114, 514, 714, 914, 1014, 1114) mit jeweils mindestens einem Medienausgang (118, 518, 718, 9,18, 1018, 1019, 1118, 1119) und den einen oder die mehreren Medienzugänge (112, 712, 912, 1012, 1112) mit dem mindestens einen Medienausgang (118, 518, 718, 9,18, 1018, 1019, 1118, 1119) der wenigstens zwei Ausgabeterminals (114, 514, 714, 914, 1014, 1114) verbindende Fluidleitungen (116, 120) aufweist. In wenigstens einer der Fluidleitungen (116, 716, 916, 1016, 1017, 1116, 1117) ist ein aktiv ansteuerbares Element (130, 730, 930, 1030, 1130) zum Manipulieren und/oder Detektieren des Mediums in den Fluidleitungen (116, 716, 916, 1016, 1017, 1116, 1117) eingeschaltet. Die Erfindung betrifft weiterhin ein Fluidiksystem mit einem solchen Dosierkopf (110, 710, 910, 1010,1110), einer mikrofluidischen Kartusche und wenigstens einem Verbindungselement zur fluidischen Verbindung des Dosierkopfes (110, 710, 910, 1010,1110) mit der mikrofluidischen Kartusche. Das Ausgabeterminal (114, 514, 714, 914, 1014, 1114) ist zur mittelbaren oder unmittelbaren Aufnahme des Verbindungselements (140) eingerichtet. Die mikrofluidische Kartusche weist wenigstens eine Eingabeöffnung zur Konnektierung mit dem wenigstens einen Verbindungselement (140), und eine mit der Eingabeöffnung (133) in fluidischer Verbindung stehende Kanalstruktur (134) auf.
PCT/EP2022/061985 2021-05-06 2022-05-04 Dosierkopf und fluidiksystem zur aufnahme und dosierung wenigstens eines mediums WO2022233937A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP22727838.9A EP4334036A2 (de) 2021-05-06 2022-05-04 Dosierkopf und fluidiksystem zur aufnahme und dosierung wenigstens eines mediums

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102021204570.7 2021-05-06
DE102021204570.7A DE102021204570A1 (de) 2021-05-06 2021-05-06 Dosierkopf und Fluidiksystem zur Aufnahme und Dosierung wenigstens eines Mediums

Publications (2)

Publication Number Publication Date
WO2022233937A2 WO2022233937A2 (de) 2022-11-10
WO2022233937A3 true WO2022233937A3 (de) 2023-03-09

Family

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Family Applications (1)

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PCT/EP2022/061985 WO2022233937A2 (de) 2021-05-06 2022-05-04 Dosierkopf und fluidiksystem zur aufnahme und dosierung wenigstens eines mediums

Country Status (3)

Country Link
EP (1) EP4334036A2 (de)
DE (1) DE102021204570A1 (de)
WO (1) WO2022233937A2 (de)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040239044A1 (en) * 2001-09-21 2004-12-02 Fritz Blatter Sealing system with flow channels
EP1542000A1 (de) * 2002-07-31 2005-06-15 Kabushiki Kaisha Toshiba Basensequenzerkennungseinrichtung und automatischer basensequenzanalysierer
DE60132100T2 (de) * 2000-08-30 2008-12-18 Biodot, Inc., Irvine Verfahren zur hochgeschwindigkeits-mikrofluidischen-dispergierung
WO2010118637A1 (zh) * 2009-04-14 2010-10-21 Huang Yanyi 微流分配装置、其制备方法及用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10204414A1 (de) 2002-02-04 2003-09-04 Siemens Ag Mikrofluidik-System
DE102007018752B4 (de) 2007-04-20 2011-09-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung und Verfahren zum geregelten Transport mikrofluidischer Proben
EP2191135A1 (de) 2007-09-12 2010-06-02 Gernot Heuser Mikrodosiersystem
US8100293B2 (en) 2009-01-23 2012-01-24 Formulatrix, Inc. Microfluidic dispensing assembly
US20130202453A1 (en) 2012-02-03 2013-08-08 Eunki Hong Micro-fluidic pump
WO2017096243A1 (en) 2015-12-04 2017-06-08 President And Fellows Of Harvard College Elastomeric gasket for fluid interface to a microfluidic chip
US10674931B2 (en) 2016-01-15 2020-06-09 Case Western Reserve University Dielectric sensing for sample characterization
JP2020524789A (ja) 2017-06-21 2020-08-20 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハーＢｏｅｈｒｉｎｇｅｒ Ｉｎｇｅｌｈｅｉｍ Ｖｅｔｍｅｄｉｃａ ＧｍｂＨ サンプルを前処理するための圧縮可能抽出器具
CH714486A1 (de) 2017-12-21 2019-06-28 Integra Biosciences Ag Probenverteilsystem und Verfahren zum Verteilen von Proben.
US11590488B2 (en) 2019-03-06 2023-02-28 Festo Se & Co. Kg Dosing device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60132100T2 (de) * 2000-08-30 2008-12-18 Biodot, Inc., Irvine Verfahren zur hochgeschwindigkeits-mikrofluidischen-dispergierung
US20040239044A1 (en) * 2001-09-21 2004-12-02 Fritz Blatter Sealing system with flow channels
EP1542000A1 (de) * 2002-07-31 2005-06-15 Kabushiki Kaisha Toshiba Basensequenzerkennungseinrichtung und automatischer basensequenzanalysierer
WO2010118637A1 (zh) * 2009-04-14 2010-10-21 Huang Yanyi 微流分配装置、其制备方法及用途

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Publication number Publication date
DE102021204570A1 (de) 2022-11-10
EP4334036A2 (de) 2024-03-13
WO2022233937A2 (de) 2022-11-10

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