WO2022229021A1 - Dispositif et procédé d'évacuation de gélules individuelles - Google Patents

Dispositif et procédé d'évacuation de gélules individuelles Download PDF

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Publication number
WO2022229021A1
WO2022229021A1 PCT/EP2022/060706 EP2022060706W WO2022229021A1 WO 2022229021 A1 WO2022229021 A1 WO 2022229021A1 EP 2022060706 W EP2022060706 W EP 2022060706W WO 2022229021 A1 WO2022229021 A1 WO 2022229021A1
Authority
WO
WIPO (PCT)
Prior art keywords
capsules
relative
capsule
blocking
locking
Prior art date
Application number
PCT/EP2022/060706
Other languages
German (de)
English (en)
Inventor
Josef THIERMEYER
Original Assignee
Packsys Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Packsys Gmbh filed Critical Packsys Gmbh
Priority to EP22724730.1A priority Critical patent/EP4330160A1/fr
Publication of WO2022229021A1 publication Critical patent/WO2022229021A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/04—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, or spherical or like small articles, e.g. tablets or pills
    • B65D83/0409—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, or spherical or like small articles, e.g. tablets or pills the dispensing means being adapted for delivering one article, or a single dose, upon each actuation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0076—Medicament distribution means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2583/00—Containers or packages with special means for dispensing contents
    • B65D2583/04—For dispensing annular, disc-shaped or spherical or like small articles or tablets
    • B65D2583/0472—For dispensing annular, disc-shaped or spherical or like small articles or tablets characterised by the dispensing action
    • B65D2583/0477—For dispensing annular, disc-shaped or spherical or like small articles or tablets characterised by the dispensing action the container is maintained in the same position during the dispensing of several successive articles or doses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2583/00—Containers or packages with special means for dispensing contents
    • B65D2583/04—For dispensing annular, disc-shaped or spherical or like small articles or tablets
    • B65D2583/0472—For dispensing annular, disc-shaped or spherical or like small articles or tablets characterised by the dispensing action
    • B65D2583/0477—For dispensing annular, disc-shaped or spherical or like small articles or tablets characterised by the dispensing action the container is maintained in the same position during the dispensing of several successive articles or doses
    • B65D2583/0481—One reciprocating action, e.g. to or from

Definitions

  • the invention relates to a device for dispensing individual capsules or dragees, in particular hard capsules or coated soft capsules, and a method for dispensing individual capsules or dragees in such a device.
  • Capsules or dragees with a capsule-like shape are used for both pharmaceutical presentations and food supplements. Coated soft capsules or hard capsules are often used.
  • Hard capsules can contain a wide variety of contents, such as powder, granules, pellets, individual tablets, liquids and even capsules.
  • various combinations of the above possible contents can be combined with each other, such as different pellets, pellets and powder, powder and tablets, pellets and tablet, pellets and capsules, but also pellets and tablets in liquid or powder and an inhalable content.
  • Hard capsules are standardized with regard to different capsule sizes.
  • the object of the invention is to propose a capsule dispenser that is easy to use and allows capsules or coated tablets to be removed hygienically.
  • capsules or a capsule dispenser it should be clear that reference is made in the same way to coated tablets, which also have a capsule-like shape.
  • the device according to the invention for separating and dispensing capsules or dragees, in particular hard capsules or coated soft capsules comprises a first element with a longitudinal axis and a second element that can be displaced in the direction of the longitudinal axis relative to the first element and that is in a first position when at rest and biased to the first position by a resilient member.
  • the second element comprises a storage space for capsules and an actuating element
  • the first element comprises a dispensing opening for a capsule and a dosing device with a first blocking element and a second blocking element.
  • the first locking element and the second locking element are arranged such that when the second element is displaced relative to the first element against the bias of the elastic element by a first distance into a first operating position, the actuating element actuates only the first blocking element, and upon further displacement of the second element against the bias of the elastic element relative to the first element by a second distance into a second operating position, the actuating element actuates both the first blocking element and the second blocking element.
  • the device according to the invention can be constructed from a few individual parts.
  • the sequence of actuations of a first blocking element and a second blocking element allows the individual steps required for the separation and dispensing of capsules to be implemented in a simple manner.
  • the second element only needs to be moved relative to the first element in order to actuate the dosing element.
  • the elastic element which biases the second element into the first position, then automatically returns the device to the starting position.
  • a user therefore only has to perform a single actuation step, during which the second element is displaced in the longitudinal direction relative to the first element in order to dispense a single capsule.
  • the device further comprises a dosing cap which can be detachably fastened to the first element in the region of the dispensing opening.
  • a dosing cap has the advantage that even with the desired dosing of a single capsule, it does not come into contact with a user's hand since it is not necessary to remove the single capsule either dispensed directly into the palm of the hand, or dispensed onto a surface or into a container and removed from there again manually.
  • the provision of the dosing cap allows the dispensed individualized capsule to be taken orally directly by means of the dosing cap.
  • Fastening the dosing cap in the area of the dispensing opening also has the further advantage that the capsule dispenser with the dosing cap in place can also be tightly sealed in the area of the dispensing opening.
  • a dosing cap has the advantage that the dosing cap can be fastened to the first element in such a way that even if children operate the device, they cannot remove the capsule from the dosing cap and inadvertently ingest it.
  • the dosing cap can preferably be moved in the direction of the longitudinal axis relative to the first element between a first dosing position and a second dosing position, wherein in the second dosing position there is a collection volume between the dosing cap and the dispensing opening for receiving a capsule passing through the receiving opening.
  • the dosing cap can be fastened to the first element in such a way that only in the second dosing position is there a sufficiently dimensioned collection volume for receiving a capsule, while in the first dosing position the dosing cap is arranged at a small distance from the dispensing opening. In this way, the device according to the invention is tightly closed with a low total volume, which increases the storage time of capsules that react sensitively to atmospheric moisture, for example.
  • the second element is essentially rotationally symmetrical in relation to the longitudinal axis and can be rotated about the longitudinal axis relative to the first element.
  • the second element is relative to not only in the direction of the longitudinal axis first element displaceable, but also rotatable about the longitudinal axis relative to the first element.
  • This additional relative mobility can be used to provide a defined locking position between the first element and the second element, in which no displacement in the longitudinal direction of the second element relative to the first element is possible, so that in terms of transport security in this position the device cannot be activated unintentionally.
  • this locked state not only serves as a transport lock, but can also serve as a child lock to prevent children from removing and ingesting a capsule.
  • the first blocking element is preferably elastically deformable as a result of the displacement of the actuating element. This represents a very simple design of the first blocking element, which is only elastically displaceable from a rest position into an operating position when the second element is displaced relative to the first element by the first distance and automatically returns elastically to the rest position when the actuating element is no longer is engaged with the first locking element.
  • the second locking element is elastically deformable by the displacement of the actuating element.
  • the actuating member which is part of the second member, is also displaced the second distance and engages the second locking member which is elastic from the rest position to the operative position is postponed.
  • this returns elastically to its rest position when the Actuating element is no longer engaged with the second blocking element.
  • the first element also includes a separating device which, in the second operating position, extends into the storage space of the second element.
  • a separating device which, in the second operating position, extends into the storage space of the second element.
  • the separating device serves to loosen the capsules located in the storage space of the second element and thus prevents several capsules located in the storage space from blocking each other in special mutual arrangements and no further capsule migrates in the direction of the dosing device. It has proven to be particularly suitable for this purpose
  • the device according to the invention preferably also comprises a removable cover which closes a filling section of the storage space.
  • a removable lid makes the device reusable in that it can be refilled with capsules once the original fill has been dispensed.
  • the container in such a way that the second element is firmly closed at the top and the lid cannot therefore be removed by the user.
  • the device further comprises a dry canister in the storage space. In this way, not only can the service life of the device be extended, but also the storage time, particularly in tropical countries, since atmospheric moisture that penetrates into the container or diffuses through the walls can be absorbed by the drying canister.
  • the dry canister is a commercially available dry canister, as is often used in the packaging of pharmaceutical products. Commonly used absorbents in the dry canister are silica gel or zeolites.
  • the method according to the invention for the individual dispensing of capsules, in particular hard capsules or coated soft capsules or coated tablets, in a device according to the invention comprises the steps:
  • the device according to the invention is easy and intuitive to use and dosing of a single capsule with a single actuating movement is possible, but above all because hygienic removal of a single capsule is possible, this device can be used according to the invention for hard capsules and coated soft capsules with pharmaceutically active ingredients or food supplements use.
  • the device according to the invention can be provided with an originality protection in a simple manner. For this it is only necessary, for example, to apply a welded sealing foil in such a way that it adheres to both the area of the first element and the area of the second element and in this way prevents the relative displacement between the first element and the second element. If a dosing cap is provided on the device, alternatively or additionally, a sealing foil or an adhesive label can be provided between the first element and the dosing cap, which can be severed by the user in the area of the seam between the first element and the dosing cap, so that without destroying the Originality protection no capsule can be removed from the dosing cap.
  • Fig.l shows an external view of the device according to the invention in the unactuated state
  • Figure 2 shows a sectional view of the device shown in Figure 1 in the unactuated condition
  • FIG. 3 shows detail A in Fig. 2 enlarged
  • Fig. 5 is an enlarged view of area B shown in Fig. 2;
  • FIG. 7 is an enlarged view of area C shown in FIG. 2.
  • the container 10 shown in FIG. 1 for separating and dispensing capsules comprises a first element 12 with an essentially cylindrical housing 14 which is designed essentially rotationally symmetrical to the axis of rotation x.
  • a second member 16 extends longitudinally upwardly beyond the first member 12, which term is defined above as if the container shown in Figure 1 were standing upright on a flat surface with the dispensing opening discussed below down.
  • the second element has a housing 18 which extends radially inwards in the housing 14 of the first element 12 and is displaceable in the direction of the arrow L relative to the housing 14 of the first element. A shift against that in Fig. 2 The direction of arrow L shown is only possible up to the unactuated state shown in FIGS.
  • the second element 16 is provided with a filling opening 22 which is closed by a cover 24 .
  • the cover can either be firmly connected to the housing 18 of the second element after the container 10 has been filled by the manufacturer, or the cover 24 can be removed by a user in order to be able to fill the container 10 repeatedly.
  • a receptacle 66 can be integrated into the cover 24, which is used to insert a conventional, cylindrical drying canister.
  • a dosing cap 26 is releasably connected to the first member 12 on the underside of the container.
  • the dosing cap can be manufactured in such a way that it can be pulled off the first element 12 in the direction of the arrow L and pushed onto the first element 12 in the opposite direction to the arrow L, where the dosing cap 26 can be frictionally fastened on the first element 12 of the container.
  • the dosing cap can also have a
  • Form-fit connection can be snapped on or connected to the first element via a threaded connection.
  • the dosing cap seals against the first element 12 .
  • a relatively large collection volume 28 is provided for accommodating a capsule.
  • a collection volume 28 could only be present if the dosing cap 26 has already been partially removed from the first element, for example by a relative rotation through a specific angular range, as a result of which the bottom 30 of the dosing cap 26 is separated from the bottom surface 32 of the first element 14 removed and thereby a collection volume 28 is formed.
  • the second element 16 has a storage space 34 for capsules to be dispensed.
  • a drying canister (not shown) could also be provided in the storage space 34 to protect moisture-sensitive capsules by adsorbing moisture that has penetrated the drying canister when opening the lid 24 and refilling the storage space 34 with capsules and consequently removing it from the interior atmosphere in the storage space 34.
  • the housing 18 of the second element is provided in the lower region with a funnel-shaped taper 36 which merges into an annular portion constituting an actuating element 38 of the container 10.
  • the first member 12 is provided with a single capsule dispensing opening 40 located in the bottom surface 32 of the first member 12 .
  • a first locking element 42 and a second locking element 44 are provided in the first element 12, which are elastically deformable.
  • the first blocking element 42 and the second blocking element 44 can either be designed in one piece with the housing of the first element or be part of a separately provided dosing device 64 which is located in the first element 12 .
  • an elastic element is provided in the form of a helical spring 46 which rests on an annular shoulder 48 of the first element and rests in the area of the funnel-shaped section of the housing 18 of the second element, whereby the restoring force of the helical spring 46 the second element 16 is displaced counter to the direction of the arrow L relative to the first element until the first element and the second element are in contact with one another at the stop 20 and no further longitudinal displacement counter to the direction of the arrow L is possible.
  • FIG. 3 the area A shown in FIG. 2 is shown enlarged.
  • the discharge channel 50 for capsules which is arranged stationary in the first element 12 and in which a first capsule 61 and a second capsule 62 are located, is also shown more clearly.
  • the first capsule 61 is located closer to the dispensing opening 40 in the dispensing channel.
  • the first capsule 61 and the second capsule 62 are in direct contact with one another. However, they cannot leave the container through the dispensing opening 40 because above the dispensing opening 40 the second locking element 44 holds the first capsule 61 with its locking lug 52 and prevents it from moving further in the direction of gravity towards the dispensing opening 40.
  • the output channel 50 widens in the shape of a funnel on its upper side to a separating end 60 .
  • the dispensing channel may be provided with guide ribs 54 to center and align the elongate capsules entering the dispensing channel 50 of the first member from the reservoir 34 of the second member.
  • the first blocking element 42 has no function in the unactuated state of the container shown in FIGS. 1 to 3.
  • FIGS. 4 to 7 show a relative displacement of the second element 16 relative to the first element, with the second element being moved by a distance S1 relative to the first element in FIGS. 4 and 5 by the user pressing the lid from above 24 presses.
  • 4 and 5 show the first operating position of the device according to the invention.
  • the displacement has of the second element relative to the first element by the distance S1 with the result that the actuating element 38, which is part of the housing of the second element, presses against the first locking element 42, as a result of which the first locking element 42 bends elastically and with its separating lug 56 into a Opening 58 of the output channel 50 penetrates.
  • the elastic displacement of the separating nose 56 into the dispensing channel 50 prevents the second capsule 62 from being able to fall down in the dispensing channel 50 under the influence of gravity.
  • the first capsule 61 In the first operating position, the first capsule 61 cannot pass through the dispensing opening 40 and fall into the collection volume 28 of the dosing cap 26 because the locking lug 52 of the second locking element 44 is in the locking position in which it protrudes into the dispensing channel 50 and a movement downwards of the first capsule 61 is prevented. Accordingly, in the first operating position, the second locking element 44 is in the position which is present in the unactuated state which was illustrated in FIGS.
  • the separating end 60 of the output channel 50 protrudes into the storage space 34 .
  • the consequence of this is that the capsules (not shown) located in the storage space 34 are loosened and the next capsule to be dispensed is moved into the dispensing channel 50 .
  • the capsules located in the storage space 34 tend to be arranged relative to one another in such a way that the highest possible packing density is produced. In this case, several capsules arranged in contact with one another can wedge one another in the storage space, so that no more capsules can fall down. This high packing density is eliminated by the singulation end 60 of the output channel 50 penetrates into the reservoir 34 from below when the container is actuated.
  • FIGS. 6 and 7 With a further relative movement of the second element relative to the first element in the direction of the arrow L by pressure on the cover 24, the situation that is shown in FIGS. 6 and 7 arises. This corresponds to the second operating position of the device according to the invention.
  • the first operative position shown in the preceding figures 4 and 5 was only shown to illustrate the operation of the container according to the invention, but it is ultimately a snapshot in the course of the continuous operation of the container.
  • the distance S2 shown in FIGS. 6 and 7 is slightly larger than the distance S1. If one compares Fig. 6 and 7 with those according to Fig.
  • the second capsule 62 is prevented from moving in the direction of gravity in the dispensing channel 50 in the second operating position, since the separating nose 56 of the first blocking element 42 protrudes into the passage volume of the dispensing channel 50 .
  • the actuating element 38 is also moved upwards, as a result of which the actuating element 38 no longer presses on the first locking element 42 and the first locking element 42 elastically returns to its unloaded position in which the separating nose 56 no longer protrudes into the output channel 50.
  • the state shown in FIGS. 2 and 3 is restored, in which the previous second capsule falls down and assumes the position of the previous first capsule.
  • Another capsule from the storage space 34 advances into the dispensing channel 50 and takes the position of the second capsule which is above and in contact with the first capsule which is next to be dispensed.
  • an actuation lock can also be provided, which prevents a relative movement in the direction of the arrow L of the second element relative to the first element.
  • the housing 14 of the first element and the housing 18 of the second element are configured concentrically relative to one another in some areas and are essentially rotationally symmetrical to one another. Therefore, the second element can be rotated relative to the first element about the longitudinal axis X (see Fig. 1).
  • Locking can be established by providing suitable locking elements, such as axially arranged locking grooves and locking ribs.
  • first and second element are designed so that a longitudinal displacement of the second element relative to the first element is only possible in a specific rotational position, while in all other positions a displacement movement is blocked, or that the second element is only blocked in the longitudinal direction relative to the first element in a defined angular position to one another is, while in all other rotational positions relative to each other, a longitudinal displacement between the second element and the first element is possible.
  • the container according to the invention can be handled easily and intuitively, with one-handed operation being possible. With each actuation, only a single capsule is dispensed, which can then be taken directly using the dosing cap, so that there is no contact with the user's palm and the associated risk of contamination.
  • a further advantage of the device according to the invention is that, in particular when dosing coated soft capsules, it is not necessary to press the soft capsules out of a blister pack, as a result of which the capsules could be deformed. Due to the high tightness of the container, a long service life and storage time can also be made possible.
  • the container according to the invention can be manufactured from pharmaceutically certified plastic materials, with the dosing cap preferably being made from a transparent material, for example polyethylene or polypropylene. Secondary packaging is not required.
  • the dosing device is manufactured in one piece as a structural unit comprising the output channel, the first blocking element and the second blocking element, this structural unit can easily be exchanged for a similarly constructed structural unit with a modified geometry in order to accommodate the container for dosing capsules of different sizes.

Abstract

L'invention concerne un dispositif d'évacuation de gélules ou de dragées individuelles, en particulier des gélules dures ou des gélules molles enrobées, comprenant un premier élément (12) ayant un axe longitudinal X et un deuxième élément (16) qui peut être déplacé par rapport au premier élément (12) dans la direction de l'axe longitudinal X et qui est situé dans une première position dans un état de repos et est précontraint dans la première position par un élément élastique (46). Le deuxième élément comprend une chambre de stockage (34) pour des gélules et un élément d'actionnement (38). Le premier élément (12) comprend une ouverture d'évacuation (40) pour une gélule et un dispositif de dosage pourvu d'un premier élément de blocage (42) et d'un deuxième élément de blocage (44). Le premier élément de blocage (42) et le deuxième élément de blocage (44) sont disposés de telle sorte que, lorsque le deuxième élément (16) est poussé d'une première distance (S1) par rapport au premier élément (12) dans une première position de fonctionnement contre la précontrainte de l'élément élastique (46), le premier élément d'actionnement (38) actionne uniquement le premier élément de blocage (42), et lorsque le deuxième élément (16) est poussé d'une deuxième distance (S2) par rapport au premier élément (12) dans une deuxième position de fonctionnement contre la précontrainte de l'élément élastique (46), l'élément d'actionnement (38) actionne à la fois le premier élément de blocage (42) et le deuxième élément de blocage (44).
PCT/EP2022/060706 2021-04-26 2022-04-22 Dispositif et procédé d'évacuation de gélules individuelles WO2022229021A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP22724730.1A EP4330160A1 (fr) 2021-04-26 2022-04-22 Dispositif et procédé d'évacuation de gélules individuelles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21170402.8 2021-04-26
EP21170402.8A EP4082937A1 (fr) 2021-04-26 2021-04-26 Dispositif et procédé de distribution individuelle de capsules

Publications (1)

Publication Number Publication Date
WO2022229021A1 true WO2022229021A1 (fr) 2022-11-03

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2022/060706 WO2022229021A1 (fr) 2021-04-26 2022-04-22 Dispositif et procédé d'évacuation de gélules individuelles

Country Status (2)

Country Link
EP (2) EP4082937A1 (fr)
WO (1) WO2022229021A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2350605A (en) * 1997-01-10 2000-12-06 Nelson & Co Ltd A Dispenser
WO2005044702A1 (fr) * 2003-10-27 2005-05-19 Csp Technologies, Inc. Distributeur d'objets solides comportant un mecanisme de levier double
FR3088625A1 (fr) * 2018-11-20 2020-05-22 Stiplastics Dispositif securise de comptage et de distribution d’objets

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2350605A (en) * 1997-01-10 2000-12-06 Nelson & Co Ltd A Dispenser
WO2005044702A1 (fr) * 2003-10-27 2005-05-19 Csp Technologies, Inc. Distributeur d'objets solides comportant un mecanisme de levier double
FR3088625A1 (fr) * 2018-11-20 2020-05-22 Stiplastics Dispositif securise de comptage et de distribution d’objets

Also Published As

Publication number Publication date
EP4082937A1 (fr) 2022-11-02
EP4330160A1 (fr) 2024-03-06

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