WO2022226894A1 - 一种在鼻通道内缓慢释放化合物的缓释装置 - Google Patents

一种在鼻通道内缓慢释放化合物的缓释装置 Download PDF

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Publication number
WO2022226894A1
WO2022226894A1 PCT/CN2021/090988 CN2021090988W WO2022226894A1 WO 2022226894 A1 WO2022226894 A1 WO 2022226894A1 CN 2021090988 W CN2021090988 W CN 2021090988W WO 2022226894 A1 WO2022226894 A1 WO 2022226894A1
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WO
WIPO (PCT)
Prior art keywords
nasal
arm
nasal passage
elastic
expansion
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PCT/CN2021/090988
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English (en)
French (fr)
Inventor
王雷
Original Assignee
王雷
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 王雷 filed Critical 王雷
Priority to PCT/CN2021/090988 priority Critical patent/WO2022226894A1/zh
Priority to EP21938374.2A priority patent/EP4331657A1/en
Priority to CN202180089069.4A priority patent/CN117279683A/zh
Priority to AU2021443106A priority patent/AU2021443106A1/en
Priority to CA3216564A priority patent/CA3216564A1/en
Priority to JP2023566713A priority patent/JP2024515869A/ja
Publication of WO2022226894A1 publication Critical patent/WO2022226894A1/zh
Priority to US18/470,632 priority patent/US20240009411A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • A61M15/085—Fixing means therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M29/00—Dilators with or without means for introducing media, e.g. remedies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A62—LIFE-SAVING; FIRE-FIGHTING
    • A62B—DEVICES, APPARATUS OR METHODS FOR LIFE-SAVING
    • A62B9/00—Component parts for respiratory or breathing apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/08—Supports for equipment
    • A61M2209/088—Supports for equipment on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0618—Nose

Definitions

  • the invention belongs to the technical field of medical devices, and relates to a sustained-release device for slowly releasing compounds in nasal passages.
  • Nasal sprays are commonly used to treat allergic rhinitis and blocked nasal passages.
  • the active ingredients of these drugs stimulate hormone receptors in the nose, constrict blood vessels, relieve nasal congestion and nasal congestion. Due to the direct contact of a large dose of the drug with the nasal mucosa in a short period of time, the number of the receptors will decrease rapidly. After a period of time, the nasal mucosa will become more congested and inflamed, and the blood vessels will become brittle and prone to nosebleeds.
  • the sustained-release technology can avoid the instantaneous impact of the drug on the nasal mucosa, thereby reducing or even avoiding the occurrence of the above-mentioned side effects.
  • a type of nose clip incorporates volatile aromatic compounds into the material.
  • This type of nose clip has a simple structure and is easy to wear, but it will cause the aromatic compounds to directly contact and stimulate the inner wall of the nasal passage; and the aroma it carries
  • this type of nose clip does not have the function of dilating the nasal passage, so it will hinder breathing to a certain extent;
  • a class of nose clips is provided with an openable and closable cavity, the compound is placed in it, and the compound is released into the nasal passage through the opening on the cavity; however, because the cavity is provided, this type of nose clip is relatively thick , and does not have the function of expanding the nasal passage, so it will hinder breathing to a certain extent; in addition, because the opening and closing device of the cavity is small and complex, and its reliability is low, once it fails, it may cause an inhalation risk;
  • the end of a class of nose clips is provided with a round tube, and a solid aromatic compound is placed in the round tube, and the solid compound is fixed by the narrowed part in the middle of the round tube; however, this type of nose clip cannot release the liquid compound; Moreover, since solid aromatic compounds are not hard, their fixing methods are not reliable enough, which may cause inhalation risks; in addition, such nose clips do not have the function of dilating nasal passages, so they will hinder breathing to a certain extent;
  • a type of nose clip is provided with an expansion element used to expand the nasal passage and a release element fixed on the expansion element for releasing the compound; the ventilation of this type of nose clip is better than other nose clips, but its expansion element is different from the nasal passage.
  • the contact area of the inner wall is small, and the pressure on the inner wall of the nasal passage is large, which is easy to cause discomfort, and it is difficult to expand the nasal passage in all directions; in addition, the expansion element is not provided with elastic support spokes, so there is insufficient expansion strength and balance. , and it is difficult to carry out targeted expansion of specific parts of the nasal passage; furthermore, its release element can only accommodate a small amount of compounds in a specific state and type, and the opening and closing device is small and complicated, and its reliability is insufficient;
  • a type of nose clip has both filtering and releasing functions, and it includes a pair of cylindrical containers connected together by connecting strips, and the cylindrical container is provided with a filter and an absorbing gasket capable of absorbing liquid medicine, and the absorbing gasket can The drug is released into the inhaled air stream; however, these types of nose clips cannot release solid compounds; and the inhaled air passes through the filter and absorbent pad, and the breathing resistance is high, so it is less versatile and only suitable for specific situations.
  • the present invention proposes a sustained-release device for slowly releasing a compound in a nasal passage.
  • the sustained-release device includes: a connection mechanism, two expansion mechanisms, and two release mechanisms;
  • the two ends of the connecting mechanism are respectively integrally or detachably connected to two expansion mechanisms symmetrically arranged in the nasal passages on both sides;
  • the two release mechanisms are symmetrically arranged, and each release mechanism is correspondingly arranged in each expansion mechanism Inside;
  • the connecting mechanism includes at least one connecting beam, the connecting beam half surrounds the lower end of the nasal septum, which includes: a middle part located on the lower side of the nasal septum and two connecting arms symmetrically arranged on both sides of the nasal septum; the middle part is located between the two connecting arms. between the arms; the two connecting arms are respectively connected to two expansion mechanisms symmetrically arranged in the two nasal passages;
  • the release mechanism includes: at least one fixation tube and at least one release element;
  • the fixing tube is a tubular structure, which is arranged on the expansion mechanism; the releasing element is a structure with wide ends and a narrow middle.
  • the fixing tube surrounds the thinner middle of the releasing element.
  • the two ends of the release element are located outside the two ends of the fixed tube, and the maximum width of the two ends of the release element is greater than the maximum width of the inner cavity of the fixed tube; the release element can accommodate a certain amount of compound and allow the accommodated compound to be in the nose. Slow release in the channel, when worn, at least part of the release element is located in the nasal channel.
  • the expansion mechanism includes: an elastic expansion arm; the elastic expansion arm is an annular closed structure, which is connected with the end of a connecting arm; the fixing tube is arranged on the inner side of the elastic expansion arm. On the surface, the release element is sleeved in the fixed tube.
  • the two connecting arms of the connecting beam are symmetrically provided with widened portions, and the width of the surface of the connecting arms toward the side of the nasal septum increases at the widened portion; the two widened portions are widened.
  • the top fits both sides of the nasal septum and applies a clamping force to the nasal septum.
  • the expansion mechanism includes: an elastic expansion arm and at least one elastic support spoke;
  • the elastic expansion arm is an annular closed structure, which is connected with the end of one connecting arm; the elastic support spoke is bifurcated and includes a plurality of branches, one end of each branch is connected to the main part of the elastic support spoke, and the other end is fixed On the elastic expansion arm; the fixing tube is arranged on the elastic support spoke, and the releasing element is sleeved in the fixing tube.
  • the elastic support spokes, the fixing tube and the releasing element are located above the elastic expansion arm, forming an inverted bowl-like structure.
  • the expansion mechanism includes: an elastic expansion arm and at least one elastic support spoke;
  • the elastic expansion arm is an annular closed structure, which is connected with an end of a connecting arm; the elastic support spoke is a belt-like structure, and its two ends are connected to the elastic expansion arm.
  • the connecting mechanism includes a first connecting beam and a second connecting beam arranged longitudinally side by side; both the first connecting beam and the second connecting beam half surround the lower end of the nasal septum.
  • the two second connecting arms of the second connecting beam are symmetrically provided with protrusions facing the wearer's nasal septum; the protrusions fit both sides of the nasal septum and apply a bag to the nasal septum clamping force.
  • the ends of the two second connecting arms of the second connecting beam are provided with plugs, and the plugs are inserted into the sockets provided at the roots of the first elastic support spokes, and the plugs are
  • the structure with wide ends and narrow middle realizes plug-in fixation.
  • the expansion mechanism includes: an elastic expansion arm, a nasal passage engaging element and at least one elastic support spoke;
  • the elastic expansion arm is an elastically compressible open band-like structure, which is connected with the end of a connecting arm, and the outer main surface of the elastic expansion arm can partially or completely fit the inner wall of the nasal passage, so that it can not only apply energy from the nose to the nose wing.
  • the expansion force of the elastic expansion arms and elastic support spokes can also apply the clamping force from the connecting beam to the nasal septum;
  • the nasal passage engaging element is a sheet-like structure, which is connected with the elastic expansion arm and keeps the expansion mechanism in an open structure; when worn, the nasal passage engaging element is located on the inner side of the alar of the nose, and its outer main surface is fitted with the inner wall of the alar of the nose, and faces the alar of the nose. Apply expansion force from elastic expansion arms and elastic support spokes;
  • the elastic support spokes are elastically compressible belt-like or strip-like structures, the two ends of which are connected to the elastic expansion arms or the nasal passage engaging elements.
  • the elastic expansion arm is integrated with the nasal passage engaging element.
  • the cross section of the elastic expansion arm perpendicular to the axis of the nasal passage is a V-shaped structure or a C-shaped structure, which includes: a curved part, a proximal arm and a distal arm;
  • One end of the curved portion is connected to the proximal arm, and the other end is connected to the distal arm.
  • the proximal arm When worn, the proximal arm is close to the nasal septum, the distal arm is close to the nose wing, and the curved portion is close to the bridge or bottom of the nose.
  • the end of the elastic expansion arm that is in contact with the inner wall of the nasal passage is bent toward the inside of the nasal passage; the end of the nasal passage engaging element is bent toward the inside of the nasal passage.
  • the elastic support spoke is bifurcated and has a plurality of branches, one end of each branch is connected to the main part of the elastic support spoke, and the other end is fixed to the elastic expansion arm or the nose channel joint on the component.
  • the connecting beam applies a wrapping force to the nasal septum, and the wrapping force is directly applied to the lower end of the nasal septum by the two connecting arms of the connecting beam, or the wrapping force is applied by the two connecting arms of the connecting beam After the connecting arm is transmitted to the corresponding expansion mechanism, it is applied to the lower end of the nasal septum by the corresponding expansion mechanism.
  • the average cross-sectional area of the middle portion of the connecting beam is larger than the average cross-sectional area of the connecting arm.
  • the release element includes: a medicine bucket, a bucket cover and a bucket bottom connected to and covering both ends of the medicine bucket; the maximum diameter of the bucket cover is greater than the maximum diameter of the medicine bucket; the maximum diameter of the bucket bottom greater than the maximum diameter of the medicine barrel;
  • the medicine bucket is a hollow tubular structure, the inside of which contains the compound, and at least one opening is provided on the bucket cover and the bucket bottom, so that the compound is discharged to the nasal passage through the opening.
  • an absorption block made of porous material is arranged in the medicine barrel.
  • the release element is made of porous material.
  • the outer surface of the release element is provided with a protuberance.
  • the expansion mechanism of the sustained-release device of the present invention adopts a closed structure or an open structure, which improves the function and applicability of the sustained-release device, and also improves the diversity of its specific embodiments.
  • the outer main surface of the elastic expansion arm can also fit the inner wall of the nasal passage, which increases the contact area between the expansion mechanism and the inner wall of the nasal passage, which is conducive to the all-round expansion of the nasal passage and reduces the expansion mechanism.
  • the pressure on the inner wall of the nasal passage improves comfort.
  • At least one elastic support spoke is adopted to ensure the strength and balance of the expansion, and can carry out targeted expansion to the specific part of the nasal passage.
  • the release element does not contact the inner wall of the nasal passage, so that the compound contained therein can be prevented from contacting and irritating the inner wall of the nasal passage.
  • the release element adopts a cylindrical structure, and its cross-sectional area is small, so it has less air resistance, and by increasing the length of the release element along the axis of the nasal passage, its capacity can be effectively increased without increasing air resistance.
  • the fixing method of the release element is simple and reliable, avoiding the risk of falling off and inhalation.
  • the rate at which it releases the compound can be adjusted by substituting different release elements or parts thereof.
  • Figure 1A is a side view of a human nose
  • 1B is a side cross-sectional view of a human nose
  • Figure 1C is a bottom-up top view of the human nose
  • FIG. 2 is a schematic structural diagram of a first preferred embodiment of a sustained-release device for slowly releasing a compound in a nasal passage and expanding the nasal passage according to the present invention
  • Figure 3 is a top view of a first preferred embodiment of the sustained release device of Figure 2 for slowly releasing a compound in the nasal passage and dilating the nasal passage;
  • Figure 4 is a side view from one direction of the first preferred embodiment of the sustained release device of Figure 2 for slowly releasing a compound in a nasal passage and dilating the nasal passage;
  • Figure 5 is a side view from another direction of the first preferred embodiment of the sustained release device of Figure 2 for slowly releasing a compound in a nasal passage and dilating the nasal passage;
  • FIG. 6 is a schematic structural diagram of a first preferred embodiment of the sustained-release device for slowly releasing a compound in the nasal passage and expanding the nasal passage of the present invention of FIG. 2 with an elastic support spoke;
  • FIG. 7 is a side cross-sectional view of the release element of the first preferred embodiment of the sustained-release device of FIG. 2 for slowly releasing a compound in a nasal passage and dilating the nasal passage of the present invention
  • FIG. 8 is a bottom-up plan view of the first preferred embodiment of the sustained-release device of FIG. 2 for slowly releasing a compound in the nasal passage and dilating the nasal passage of the present invention installed on the nose of a user;
  • FIG. 9 is a side view of the first preferred embodiment of the sustained-release device of FIG. 2 for slowly releasing a compound in the nasal passage and dilating the nasal passage of the present invention installed on the nose of a user;
  • Figure 10 is a schematic structural diagram of a second preferred embodiment of a sustained-release device for slowly releasing a compound in a nasal passage and expanding the nasal passage according to the present invention
  • Figure 11 is a top plan view of a second preferred embodiment of the sustained release device of Figure 10 for slowly releasing a compound in a nasal passage and dilating the nasal passage;
  • Figure 12 is a structural diagram of a second preferred embodiment of the sustained-release device for slowly releasing a compound in a nasal passage and dilating the nasal passage of Figure 10 with bifurcated elastic support spokes;
  • Figure 13 is a side cross-sectional view of the release element of the second preferred embodiment of the sustained release device of Figure 10 for slowly releasing a compound in a nasal passage and dilating the nasal passage;
  • FIG. 14 is a schematic structural diagram of a third preferred embodiment of a sustained-release device for slowly releasing a compound in a nasal passage and expanding the nasal passage according to the present invention
  • Figure 15 is a top view of a third preferred embodiment of the sustained release device of Figure 14 for slowly releasing a compound in a nasal passage and dilating the nasal passage;
  • Figure 16 is a side view of a third preferred embodiment of the sustained release device of Figure 14 for slow release of a compound in the nasal passage and expansion of the nasal passage;
  • 17A is a side cross-sectional view of the release element of the third preferred embodiment of the sustained release device of FIG. 14 for slowly releasing a compound in a nasal passage and dilating the nasal passage of the present invention
  • 17B is a side cross-sectional view of the release element of the third preferred embodiment of the slow release device of FIG. 14 for slowly releasing a compound in a nasal passage and dilating the nasal passage of the present invention, the two ends of the release element are provided have bulges;
  • Figure 18A is a top view of a positional relationship between an elastic expansion arm and a nasal passage engaging element of another embodiment of a sustained release device for slowly releasing a compound in a nasal passage and dilating the nasal passage of the present invention
  • 18B is a top view of another positional relationship between the elastic expansion arm and the nasal passage engaging element of another embodiment of a sustained release device for slowly releasing a compound in the nasal passage and dilating the nasal passage of the present invention
  • the first branch 74 The second branch
  • the description of the sustained-release device 1 in the present invention is as follows: Except for the connecting beam 2, the rest of the components are located in a nasal passage in quantity and structure.
  • the various directions of the nose according to the present invention are: the front 11 of the nose, the rear 12 of the nose, the upper part 13 of the nose, and the lower part 14 of the nose.
  • the side of the object close to the nasal passage axis 97 is “inside” and the side away from the nasal passage axis 97 is “outside”.
  • connection in the present invention means that two tangible objects are integrally connected together, or are detachably connected together through a connector, and the connection methods include but are not limited to: bonding, welding, plugging, screwing Connection, snap connection.
  • axis in the context of the present invention refers to the central axis of symmetry of the tubular or cylindrical object.
  • the axis of the standard tube or column can be used as its approximate axis.
  • FIG. 1B depicts nasal passage axis 97 .
  • cross-section in the context of the present invention refers to the cross-section of the tube or column perpendicular to its axis.
  • compound as used in the present invention is not strictly chemically defined, but shall include solid and liquid pure substances, compounds and mixtures, as well as other forms or combinations of substances suitable for use in the present invention, the compounds may be pharmaceutically or non-pharmaceutical Medicinal, including but not limited to drugs and aromatic substances.
  • closed structure is a closed plane figure composed of n (n is a positive integer) line segments or arcs, such as: circle, ellipse, polygon;
  • opening structure described in the present invention is Refers to a plane figure with an opening on a closed figure, such as C-shape, V-shape, L-shape, and arc.
  • tubular structure in the present invention refers to a columnar structure with a cavity passing through in the axial direction, and the columnar structure includes but is not limited to cylinders and prisms.
  • the sustained release device 1 of the present invention is applied to the nose 9 of a human being.
  • the nose 9 is a visually visible protruding part of the face, including: the nasal septum 91, the alar 92, the bridge 93 and the bottom 99 of the nose, and two nasal passages 95 surrounded by them.
  • the outlets of the two nasal passages 95 are the two nostrils 94 .
  • the nasal passage inner wall 96 is constituted by the inner surface of each portion surrounding the nasal passage 95 as described above.
  • the nasal passage 95 is limited to the nasal vestibule contained by the nose 9 , and does not include the nasal cavity 98 .
  • the present invention provides a sustained-release device 1 for slowly releasing a compound in the nasal passage 95 and expanding the nasal passage 95, which comprises: a connecting mechanism, two expanding mechanisms and two releasing mechanisms;
  • Two ends of the connecting mechanism are respectively integrally or detachably connected to two expansion mechanisms symmetrically arranged in the nasal passages 95 on both sides; the two release mechanisms are symmetrically arranged, and each release mechanism is correspondingly arranged in each expansion mechanism.
  • the dilation mechanism is used to dilate the nasal passage 95 and the release mechanism is used to contain and release the compound.
  • the connecting mechanism includes at least one connecting beam 2, the connecting beam 2 half surrounds the lower end of the nasal septum 91, which includes: a middle portion 23 located on the lower side of the nasal septum 91 and a middle portion 23 located on the lower side of the nasal septum 91.
  • the connecting arms 24 are respectively connected to two expansion mechanisms symmetrically arranged in the two nasal passages 95; preferably, the connecting beam 2 is a U-shaped or C-shaped structure, wherein the C-shaped structure is more conducive to the ends of the connecting arms 24 A clamping force is applied to the nasal septum 91 .
  • the connecting beam 2 also provides a fixing function for the sustained-release device 1, and the minimum distance between the two connecting arms 24 is smaller than the width of the nasal septum 91, so that it applies a clamping force to the nasal septum 91, and the clamping force
  • the two connecting arms 24 of the connecting beam 2 are directly applied to both sides of the nasal septum 91, or after the two connecting arms 24 of the connecting beam 2 are conducted to the corresponding expansion mechanism, the elastic expanding arms 3 are applied to both sides of the nasal septum 91. ;
  • the above-mentioned clamping force enables the sustained-release device 1 to be clamped and fixed in the nasal septum 91 .
  • the average cross-sectional area of the middle portion 23 of the connecting beam 2 is larger than the average cross-sectional area of the connecting arm 24, so that the middle portion 23 is thicker than the connecting arm 24, thereby strengthening the connecting beam 2.
  • the connecting beam 2 in the connecting mechanism of the slow release device 1 includes: a first connecting beam 21 and a second connecting beam 22 .
  • the expansion mechanism is integrally connected and uses the same material, which cannot support the first connecting beam 21 to provide sufficient clamping force, therefore, a second connecting beam 22 is also provided at a position longitudinally juxtaposed with the first connecting beam 21, The clamping force on the nasal septum 91 is supplemented by the second connecting beam 22 .
  • the two connecting arms 24 of the connecting beam 2 are provided with protrusions 242 facing the nasal septum 91, the protrusions 242 fit on both sides of the nasal septum 91, and Apply a clamping force to the nasal septum; when the protrusion 242 provides the function of clamping and fixing, the ends of the two connecting arms 24 of the connecting beam 2 can be connected to the expansion mechanism at a position deeper into the nasal passage 95, thereby helping to dilate The mechanism and release mechanism are positioned further into the nasal passage 95 .
  • the two connecting arms 24 are provided with widened portions 241 , and the connecting mechanism applies a clamping force to the nasal septum 91 through the widened portions 241 ; and the connecting arms 24 are toward the nasal septum 91 .
  • the width of the side surface is increased at the widened portion 241 to increase the fitting area between the widened portion 241 and the nasal septum 91 , thereby reducing the pressure of the connecting beam 2 on the nasal septum 91 to improve comfort.
  • the connecting beam 2 When the connecting beam 2 is provided with the widened part 241 and the protrusion 242 at the same time, the two can be combined into the same part, and the part has the characteristics of the widened part 241 and the protrusion 242 .
  • the ends of the two connecting arms 24 of the connecting beam 2 are provided with plugs 243 .
  • the plugs 243 are wide at both ends and narrow in the middle.
  • the connecting beam 2 is fixed on the expansion mechanism by plugging;
  • the plug 243 is inserted into the insertion hole 77 provided on the elastic expansion arm 3 or the elastic support spoke 7 to realize plug-in fixation; the plug 243 is wide at both ends and narrow in the middle.
  • the structure includes: a cap 2431, a post 2432 and a handle 2433, the insertion hole 77 is tightly engaged with the post 2432, the maximum width of the handle 2433 is greater than the maximum width of the post 2432, and the maximum width of the cap 2431 is greater than the maximum width of the post 2432; At the same time, the maximum width of the handle 2433 is greater than the maximum width of the inner cavity of the socket 77, and the maximum width of the cap 2431 is larger than the maximum width of the inner cavity of the socket 77; so that the plug 243 cannot be disengaged;
  • the lumen may be prismatic to avoid rotation of the expansion mechanism about the plug 243.
  • each expansion mechanism includes: an elastic expansion arm 3 , a nasal passage engaging element 4 and at least one elastic support spoke 7 ;
  • the nasal passage engaging element 4 is a sheet-like structure, which is connected with the elastic expansion arm 3 .
  • the nasal passage engaging element 4 is located on the inner side of the nasal alar 92 and is applied to the nasal alar 92 .
  • a pair of surfaces of the nasal passage engaging element 4 parallel to the nasal passage axis 97 are its major and largest surfaces, in particular the inner major surface 41 and the outer major surface 42, the width of which is generally greater than the elastic expansion
  • the width of the ipsilateral surface of the arm 3; the outer major surface 42 fits the inner wall of the alar 92 and applies the expansion force from the elastic expansion arm 3 and the elastic support spokes 7 to the alar 92, the nasal passage engaging element 4 is perpendicular to the nasal passage axis 97
  • the surface of the subsurface is the subsurface, and the width of the subsurface is smaller than the width of the main surface, so as to reduce the breathing resistance.
  • the elastic expansion arm 3 is an elastically compressible open band structure, such as a C-shaped, V-shaped, L-shaped or arc-shaped band structure, which is connected to To the connecting arm 24 and the nasal passage engaging element 4; a pair of surfaces of the elastic expansion arm 3 parallel to the nasal passage axis 97 are its main and largest surfaces, in particular the inner main surface 34 and the outer main surface 35 , the surface of the elastic expansion arm 3 perpendicular to the nasal passage axis 97 is the secondary surface, and the width of the secondary surface is smaller than the width of the main surface to reduce the breathing resistance; as shown in FIG.
  • the outer main surface 35 of the elastic expansion arm 3 is partially Or fully fit the inner wall 96 of the nasal passage, so that it can not only apply the expansion force from the elastic expansion arm 3 and the elastic support spokes 7 to the nasal alar 92, but also apply the clamping force from the connecting beam 2 to the nasal septum 91; due to the elastic expansion Arm 3 is an open structure, so it has strong adaptability to nasal passages of different shapes and sizes, and is especially suitable for users with different sizes of left and right nasal passages caused by nasal septum deviation, thereby improving user experience and comfort, and Ergonomic design.
  • the width of the nasal passage engaging element 4 is equal to or smaller than the width of the elastic expansion arm 3, and the main surfaces on the same side of the two are smoothly connected and merged into the same surface, that is: the inner main surface 34 and the inner
  • the main surface 41 is fused into one surface
  • the outer main surface 35 and the outer main surface 42 are fused into one surface.
  • the elastic expansion arm 3 and the nasal passage engaging element 4 are integrated into one, and the function of the nasal passage engaging element 4 is completely controlled by the elastic expansion arm. 3
  • the expansion mechanism now no longer includes the nasal passage engaging element 4, but only the elastic expansion arms 3 and the elastic support spokes 7.
  • the end portion of the elastic expansion arm 3 that fits with the inner wall 96 of the nasal passage is bent toward the inside of the nasal passage 95.
  • the proximal arm 32 and the distal arm 33 of the elastic expansion arm 3 are The end is a hook 36 which can flexibly contact the inner wall 96 of the nasal passage; the end of the nasal passage engaging element 4 is bent towards the inside of the nasal passage 95 .
  • the cross section of the elastic expansion arm 3 perpendicular to the nasal passage axis 97 is a V-shaped or C-shaped structure, which includes: a curved portion 31 , a proximal arm 32 and the distal arm 33;
  • One end of the curved portion 31 is connected to the proximal arm 32, and the other end is connected to the distal arm 31.
  • the proximal arm 32 is close to the nasal septum 91
  • the distal arm 33 is close to the alar 92
  • the curved portion 31 is close to the bridge of the nose 93 or the bottom of the nose 99, that is,
  • the opening of the elastic expansion arm 3 can be toward the bridge of the nose 93 or the bottom of the nose 99; the outer main surface 35 of the elastic expansion arm 3 is in contact with the inner wall 96 of the nasal passage, as shown in FIG.
  • the inner wall 96 is compressed, the distal arm 33 and the proximal arm 32 are close to each other, and the resilient force of the curved portion 31 causes the distal arm 33 and the nasal passage engaging element 4 to apply an expansion force to the nasal alar 92, thereby expanding the nasal passage.
  • the channel engaging element 4 is in close contact with the inner wall 96 of the nasal channel, and its interaction force fixes the sustained release device 1 in the nasal channel 95 .
  • the elastic expansion arm 3 is an arc-shaped or L-shaped open band structure, one end of which is connected to the end of the connecting arm 24 and the other end is connected to the nasal passage engaging element 4
  • the inner main surface 41 of the elastic expansion arm 3 is not integrated with the nasal passage engaging element 4.
  • the outer main surface 42 of the nasal passage engaging element 4 fits the inner wall 96 of the nasal passage, but the elastic expansion arm 3 does not fit the nose.
  • the inner wall 96 of the channel in addition, because the expansion mechanism and the inner wall 96 of the nasal channel have a small abutment area, there are no elastic support spokes to provide multi-point support.
  • the elastic expansion arm 3 is an arc-shaped or L-shaped open band structure, one end of which is connected to the end of the connecting arm 24 and the other end is connected to the nasal passage engaging element 4
  • the outer main surface 42 of the nasal passage engaging element 4 fits the inner wall 96 of the nasal passage, but the elastic expansion arm 3 does not fit the inner wall 96 of the nasal passage, because the elastic expansion arm 3 and the nasal passage engaging element 4
  • the corresponding major surfaces of are not smoothly connected nor form a surface, so the two are not fused into one.
  • the elastic support spokes 7 are elastically compressible belt-like or strip-like structures, the two ends of which are connected to the elastic expansion arms 3 or the nasal passage engaging elements 4. When worn, the elastic support spokes 7 compress their own The resilient force is applied to the elastic expansion arm 3 and/or the nasal passage engaging element 4; the elastic support spokes 7 can improve the expansion force of the expansion mechanism, and at the same time, it also improves the balance of expansion, because the elastic expansion arm 3 is an open structure, the more The weaker the resilient force is near the end, the elastic support spokes 7 can provide targeted support to the specific positions of the elastic expansion arm 3 and the nasal passage engaging element 4, thereby ensuring the balance of the expansion mechanism to the expansion of the nasal passage 95 ;
  • the elastic support spoke 7 is bifurcated and includes a plurality of branches, specifically: a first branch 73, a second branch 74, a third branch 75 and a fourth branch 76, each of which One end of the branch is connected to the trunk part of the elastic support spoke 7, and the other end is fixed on the elastic expansion arm 3 or the nose channel engaging element 4; the multiple branches of the elastic support spoke 7 make it have stronger resilience, so as to further improve At the same time, its multiple branches also provide more support points, which further improves the pertinence and balance of expansion.
  • the expansion mechanism includes: an elastic expansion arm 3; the elastic expansion arm 3 is an annular closed structure, and its outer main surface 35 fits the inner wall 96 of the nasal passage;
  • the elastic expansion arm 3 is compressed by the inner wall 96 of the nasal passage, its resilience forces it to exert expansion force on all directions of the nasal passage 95; at the same time, the elastic expansion arm 3 is closely attached to the inner wall 96 of the nasal passage, and the interaction force of the two The sustained release device 1 is secured within the nasal passage 95 .
  • the annular elastic expansion arm 3 can expand the nasal passage in all directions, and can increase the contact area between the expansion mechanism and the inner wall 96 of the nasal passage, thereby reducing the pressure of the expansion mechanism on the inner wall 96 of the nasal passage to improve comfort.
  • the expansion mechanism includes: an elastic expansion arm 3 and at least one elastic support spoke 7; the elastic expansion arm 3 is an annular structure, and the elastic support spoke 7 is bifurcated and includes multiple There are two branches, specifically: the first branch 73, the second branch 74 and the third branch 75, one end of each branch is connected to the main part of the elastic support spoke 7, and the other end is fixed on the elastic expansion arm 3, when wearing, The elastic support spokes 7 apply their own compressed resilience to the elastic expansion arms 3; The inverted bowl-shaped structure facilitates the release of the compound deeper into the airway by the release mechanism.
  • the expansion mechanism includes: an elastic expansion arm 3 and at least one elastic support spoke 7; the elastic expansion arm 3 is an annular closed structure, and the elastic support spoke 7 is a flexible The elastically compressed belt-like or strip-like structure, the two ends of which are connected to the elastic expansion arm 3 .
  • each release mechanism is symmetrically arranged, each release mechanism is correspondingly arranged in each expansion mechanism, and each release mechanism includes: at least one fixing tube 5 and at least one releasing element 6 ;
  • the fixing tube 5 is a tubular structure, which is used to fix the release element 6 , the fixing tube 5 is arranged at the opening direction of the elastic expansion arm 3 , and passes through the first branch 73 , the second branch 74 , the first branch 74 , the The three branches 75 and the fourth branch 76 fix the fixing tube 5 on the trunk portion of the elastic support spokes 7 ; as shown in FIGS. 10 and 14 , in other specific embodiments, the fixing tube 5 is fixed on the The inner side or the inner side of the nasal passage engaging element 4, specifically, the fixing tube 5 as shown in FIG. 10 is fixed on the inner side of the annular elastic expansion arm 3; as shown in FIG.
  • the quadrangular prism-shaped The fixing tube 5 is fixed on the second elastic support spokes 72 .
  • the sustained-release device 1 is provided with a plurality of fixed tubes 5 and release elements 6 to increase the capacity of the compound or increase the release rate of the compound.
  • the release element 6 is a structure with wide ends and a narrow middle. When worn, the release element 6 is fixed on the fixing tube 5 , and the fixing tube 5 surrounds the lower part of the release element 6 .
  • the two ends of the release element 6 are located outside the two ends of the fixed pipe 5, and its maximum width is greater than the maximum width of the inner cavity of the fixed pipe 5, so that the release element 6 cannot be disengaged from the fixed pipe 5;
  • the release element 6 is capable of containing a certain amount of the compound and allows the compound to be slowly released in the nasal passage 95, and the release element 6 is located at least partially within the nasal passage 95 when worn.
  • the release mechanism has the following advantages: first, the fixing method is simple and reliable; second, the cross-sectional area is small and the breathing resistance is small; Increase the breathing resistance; Fourth, by replacing different types of release elements 6, it can be adapted to different compounds or provide different release rates; Fifth, the compounds contained in the release elements 6 can be easily replaced; Sixth, it can be released by adjusting The number of openings and the size of the openings in the element 6 adjust the release rate of the compound.
  • the material of the release element 6 is a porous material, which is used to absorb and store liquid compounds, and its porous surface is particularly conducive to the volatilization of the compounds, and is also conducive to The inhalation airflow from the nasal passages entrains tiny droplets of the compound, so the porous material is capable of releasing not only volatile liquid compounds, but also non-volatile liquid compounds in the form of tiny droplets.
  • the surfaces of both ends of the release element 6 made of the porous material are provided with bumps 65 to further expand the surface area and increase the release speed.
  • the release element 6 includes: a medicine bucket 61, a bucket lid 62 and a bucket bottom 63 connected to and covering both ends of the medicine bucket 61;
  • the maximum width of the barrel cover 62 and the barrel bottom 63 is greater than the maximum width of the medicine barrel 61;
  • the medicine barrel 61 is a hollow tubular structure, and its interior is used for accommodating solid and liquid compounds, and the barrel cover 62 and the barrel bottom 63 are provided with at least one Openings allow the compound to exit through the openings.
  • an absorption block 641 made of a porous material is arranged in the medicine barrel 61 to absorb and accommodate the liquid compound, prevent the liquid compound from flowing out from the opening, and can also lift the compound through its porous surface. release speed.
  • the sustained release device 1 includes: a connection mechanism, two expansion mechanisms and two release mechanisms.
  • the connecting mechanism includes: a connecting beam 2 with a U-shaped structure, the connecting beam 2 half surrounds the lower end of the nasal septum 91, as shown in Fig. 2, the connecting beam 2 Including: the middle part 23 located on the lower side of the nasal septum 91 and the two connecting arms 24 located on both sides of the nasal septum 91, the two ends of the middle part 23 are respectively connected to the two connecting arms 24; Both sides are inserted into the two nasal passages 95, which are respectively integrally connected to the two elastic expansion arms 3 symmetrically arranged in the two nasal passages 95; the minimum distance between the two connecting arms 24 is smaller than the width of the nasal septum 91 there, Make it apply a clamping force to the nasal septum 91, thereby fixing the sustained-release device 1 on the nasal septum 91; the average cross-sectional area of the middle portion 23 is greater than the average cross-sectional area of the connecting arm 24, so that the middle portion 23 is thicker than the connecting arm 24, In order to improve the
  • the two connecting arms 24 of the connecting beam 2 can be symmetrically provided with widened portions 241, and the width of the surface of the connecting arms 24 toward the nasal septum 91 side increases at the widened portion 241; the two widened portions The parts 241 fit on both sides of the nasal septum 91 and apply a clamping force to the nasal septum 91 .
  • the two connecting arms 24 of the connecting beam 2 can be symmetrically provided with protrusions 242 facing the wearer's nasal septum 91 ;
  • the ends of the two connecting arms 24 of the connecting beam 2 can be provided with plugs 243, the plugs 243 are inserted into the sockets 77 provided on the elastic expansion arms 3 or the supporting spokes, and the plugs 243 are at both ends
  • the wide and narrow structure in the middle realizes plug-in fixation.
  • each expansion mechanism includes: an elastic expansion arm 3 , a nasal passage engaging element 4 and an elastic support spoke 7 .
  • the nasal passage engaging element 4 is a sheet-like structure, which is located on the inner side of the wearer’s nose 92 , and the nasal passage engaging element 4 is connected to the end of the distal arm 33 of the elastic expansion arm 3 , a pair of surfaces parallel to the nasal passage axis 97 is its main surface and the largest surface, the pair of main surfaces are the inner main surface 41 and the outer main surface 42, the outer main surface 42 fits the inner wall of the nose 92, and Thereby, the expansion force from the elastic expansion arms 3 and the elastic support spokes 7 is applied to the alar 92, and the main surface width of the nasal passage engaging element 4 is larger than that of the distal arm 33, thereby better dispersing the expansion of the alar 92 by the expansion mechanism
  • the surface of the nasal passage engaging element 4 perpendicular to the nasal passage axis 97 is the secondary surface, and the width of the secondary surface is smaller than the width of the main surface to reduce air resistance.
  • the distal end of the nasal passage engaging element 4 can be bent inwardly of the nasal passage 95 to avoid irritation of the inner wall 96 of the nasal passage by the distal end thereof.
  • the elastic expansion arm 3 is connected with the connecting arm 24 and the nasal passage engaging element 4, and its cross section perpendicular to the nasal passage axis 97 is a V-shaped structure, the elastic expansion arm 3 comprises: a curved part 31, the proximal arm 32 and the distal arm 33; one end of the curved portion 31 is connected to the proximal arm 32, and the other end is connected to the distal arm 33; when worn, the proximal arm 32 is close to the nasal septum 91, the distal arm 33 is close to the nose 92, and the curved portion 31 Close to the bridge of the nose 93, as shown in FIGS.
  • the opening of the elastic expansion arm 3 is facing the nasal base 99 at this time; as an optimization, the proximal arm 32 of the elastic expansion arm 3 is close to the nasal septum 91, the distal arm 33 is close to the alar 92, and the curved portion 31 Close to the base of the nose 99, so that the opening of the elastic expansion arm 3 faces the nose bridge 93; a pair of surfaces of the elastic expansion arm 3 parallel to the axis 97 of the nasal passage is its main surface and the largest surface, and the pair of main surfaces is the inner main surface 34 and the outer main surface 35, the surface of the elastic expansion arm 3 perpendicular to the axis 97 of the nasal passage is the secondary surface, and the width of the secondary surface is smaller than the width of the main surface to reduce air resistance; the outer main surface 35 of the elastic expansion arm 3 is completely attached The inner wall 96 of the nose channel is closed, so that it can apply the expansion force from the elastic expansion arm 3 and the elastic support spoke 7 to the nose wing 92 .
  • the elastic expansion arm 3 when wearing, the elastic expansion arm 3 is compressed by the inner wall 96 of the nasal passage, the distal arm 33 and the proximal arm 32 are close to each other, and the resilient force of the curved portion 31 urges the distal arm 33 and the nasal passage engaging element 4 to apply to the nasal alar 92
  • the expansion force, thereby expanding the nasal passage, at the same time, the elastic expansion arm 3 and the nasal passage engaging element 4 are in close contact with the nasal passage inner wall 96 , and their interaction force fixes the sustained release device 1 in the nasal passage 95 .
  • the elastic expansion arm 3 is an open structure, it has strong adaptability to nasal passages of different shapes and sizes, and is especially suitable for users with different sizes of left and right nasal passages caused by nasal septum deviation.
  • the width of the nasal passage engaging element 4 is equal to or smaller than the width of the elastic expansion arm 3, and the main surfaces on the same side of the two are smoothly connected and merged into the same surface, that is: the inner main surface 34 and the inner
  • the main surface 41 is fused into one surface
  • the outer main surface 35 and the outer main surface 42 are fused into one surface.
  • the elastic expansion arm 3 and the nasal passage engaging element 4 are integrated into one, and the elastic expansion arm 3 and the nasal passage engaging element 4 are both attached.
  • the main surfaces of the two are actually the same surface, so they can be regarded as fused.
  • the function of the nasal passage engaging element 4 is completely replaced by the elastic expansion arm 3 , and the expansion mechanism no longer includes the nasal passage engaging element 4 , but only the elastic expansion arm 3 and the elastic support spokes 7 .
  • the ends of the proximal arm 32 and the distal arm 33 of the elastic expansion arm 3 are bent toward the inside of the nasal passage 95 to form a hook 36 to prevent the ends from irritating the inner wall of the nasal passage.
  • the expansion mechanism has a bifurcated elastic support spoke 7, which includes: a first branch 73, a second branch 74, a third branch 75 and a fourth branch 76; wherein the first branch 73 is connected to the distal arm 33 of the elastic expansion arm 3, the second branch 74 and the fourth branch 76 are connected to the proximal arm 32, and the third branch 75 is connected to the nasal passage engaging element 4; when worn, the elastic support spokes 7 compress themselves after The resilient force is applied to the elastic expansion arm 3 and the nasal passage engaging element 4; the multiple branches of the elastic support spoke 7 make it have stronger resilience, thereby further improving the expansion effect, and at the same time, its multiple branches increase the elasticity
  • the expansion arm 3 and the support point of the nasal passage engaging element 4 further improve the pertinence and balance of expansion.
  • the elastic support spoke 7 is an arc-shaped belt structure, the two ends of which are connected to different positions of the inner main surface 34 of the elastic expansion arm 3;
  • the band-shaped elastic support spokes 7 can improve the expansion effect and strengthen the pertinence and balance of expansion. At the same time, it also has the characteristics of simple structure and low air resistance; as an optimization, multiple band-shaped elastic support spokes 7 can be arranged according to actual needs. , in order to further enhance the expansion intensity and balance.
  • each release mechanism is symmetrically arranged, each release mechanism is correspondingly arranged in each expansion mechanism, and each release mechanism includes: a fixing tube 5 and a releasing element 6 ;
  • the fixing tube 5 is a circular tubular structure, which is fixed on the elastic support spokes 7, and the fixing tube 5 is used to surround and fix the release element 6; as an optimization, the fixing tube 5 can also be arranged on the elastic expansion arm 3 on the inner major surface 34, or on the inner major surface 41 of the nasal passage engaging element 4.
  • the release element 6 is a structure with wide ends and a narrow middle, which includes: a hollow cylindrical medicine barrel 61, a barrel cover 62 and a barrel bottom 63 connected to and covering both ends of the medicine barrel;
  • the outer diameter of the barrel cover 62 and the barrel bottom 63 is larger than the outer diameter of the medicine barrel 61.
  • the release element 6 is fixed on the fixing tube 5, and the fixing tube 5 surrounds the medicine barrel 61 and is tightly engaged with it.
  • the barrel cover 62 and the barrel bottom 63 are located outside the two ends of the fixed pipe 5, and its outer diameter is larger than the inner diameter of the fixed pipe 5, so that the release element 6 cannot be detached from the fixed pipe 5, and the release element 6 is located in the nose channel 95 at this time;
  • a hole 621 is released to the nasal passage; the content 64 of the medicine barrel 61 is an absorption block 641 made of porous material and the liquid compound absorbed therein.
  • the absorption block 641 can prevent the liquid compound from flowing out of the first hole 621, and its porous surface also Can increase the release rate of the compound.
  • the release mechanism can easily replace the contents 64 of the medicine bucket, and can also replace the bucket cover 62 with different opening numbers and opening sizes to adjust the release speed, and the release element 6 can be replaced with a porous material as a whole to suit different release requirements.
  • the sustained release device 1 includes: a connection mechanism, two expansion mechanisms and two release mechanisms.
  • the connecting mechanism includes: a connecting beam 2 with a U-shaped structure, the connecting beam 2 half surrounds the lower end of the nasal septum 91 , the connecting beam 2 includes: a middle part located on the lower side of the nasal septum 91 23 and two connecting arms 24 located on both sides of the nasal septum 91; the two connecting arms 24 of the connecting beam 2 are inserted into the two nasal passages 95 from both sides of the nasal septum 91, which are respectively integrally connected to the two nasal passages symmetrically arranged in the two nasal passages.
  • the connecting beam 2 also provides a fixing function for the sustained-release device 1, and the minimum distance between the two connecting arms 24 is smaller than the width of the nasal septum 91, so that it applies a clamping force to the nasal septum 91, thereby allowing the sustained-release device 1 to be wrapped.
  • the part where the connecting beam 2 exerts the clamping force on the nasal septum 91 is the widened portion 241, and the surface of the connecting arm 24 toward the nasal septum 91 becomes wider at the widened portion 241 to increase the width of the widened portion 241 and
  • the fitting area of the nasal septum 91 reduces the pressure of the widened portion 241 on the nasal septum 91 to improve comfort.
  • the two connecting arms 24 of the connecting beam 2 can be symmetrically arranged with protrusions 242 facing the nasal septum 91 of the wearer; the protrusions 242 fit both sides of the nasal septum 91 and apply a clamping force to the nasal septum 91; The protrusion 242 and the widening portion 241 can be merged into the same part.
  • the ends of the two connecting arms 24 of the connecting beam 2 can be provided with plugs 243, the plugs 243 are inserted into the insertion holes 77 of the elastic expansion arms 3, and the plugs 243 are wide at both ends and narrow in the middle structure to achieve plug-in fixing
  • each of the expansion mechanisms comprises: an annular elastic expansion arm 3 whose main and largest surfaces are a pair of surfaces parallel to the nasal passage axis 97, the pair of main surfaces It is the inner main surface 34 and the outer main surface 35, the surface of the elastic expansion arm 3 perpendicular to the nasal passage axis 97 is the secondary surface, and the width of the secondary surface is smaller than the width of the main surface to reduce breathing resistance; when wearing, the ring-shaped elastic The expansion arm 3 is inserted into the nasal passage 95 and is compressed by the inner wall 96 of the nasal passage, and its resilience forces it to exert an expansion force on the inner wall 96 of the nasal passage.
  • the sustained release device 1 is secured within the nasal passage 95 .
  • the annular elastic expansion arm 3 can expand the nasal passage in all directions, and can increase the contact area between the elastic expansion arm 3 and the inner wall 96 of the nasal passage, so as to reduce the pressure of the expansion mechanism on the inner wall of the nasal passage, thereby improving comfort.
  • FIG. 12 depicts the second preferred embodiment provided with bifurcated elastic support spokes 7.
  • the elastic support spokes 7 include: a first branch 73, a second branch 74 and a third branch 75, all of which are The elastically compressible arc-shaped strip-shaped structure, the ends of which are connected to the upper surface of the elastic expansion arm 3, and thus apply the resilient force of the elastic support spokes 7 after being pressed to the elastic expansion arm 3.
  • the multiple branches have
  • the elastic support spokes 7, the fixing tube 5 and the release element 6 are all located above the elastic expansion arm 3, so that the release element 6 can penetrate deeper into the nasal passage 95 , which facilitates its release of compounds into deeper parts of the respiratory tract.
  • each release mechanism is symmetrically arranged, each release mechanism is correspondingly arranged in each expansion mechanism, and each release mechanism includes: a fixed tube 5 and a release element 6;
  • the fixing tube 5 is a circular tubular structure, which is fixed to the inner main surface 34 of the annular elastic expansion arm 3 , and the fixing tube 5 is used to surround and fix the release element 6 ; as shown in FIG. 12 As shown, as an optimization, the fixed tube 5 is arranged on the elastic support spokes 7 .
  • the release element 6 is a structure with wide ends at both ends and a narrow middle, which includes: a tubular medicine bucket 61, a bucket cover 62 and a bucket bottom 63 connected to and covering both ends of the medicine bucket; The outer diameters of the lid 62 and the bottom 63 are larger than the outer diameter of the medicine bucket 61.
  • the release element 6 is fixed on the fixing tube 5, and the fixing tube 5 surrounds the medicine bucket 61 and is tightly engaged with it.
  • the bucket cover 62 and the barrel bottom 63 are located outside the two ends of the fixed pipe 5, and its outer diameter is larger than the inner diameter of the fixed pipe 5, so that the release element 6 cannot be detached from the fixed pipe 5, and the release element 6 is located in the nasal passage 95 at this time;
  • a cylindrical protrusion 622 is provided, and a plurality of hemispherical protrusions 624 are provided on the outside thereof. Insert the cylindrical protrusion 622 into the open end of the medicine barrel 61, so that the hemispherical protrusion 624 is connected with the plurality of clamping holes provided at the open end of the medicine barrel 61.
  • the release mechanism can easily replace the contents 64 of the medicine barrel, and can also replace the barrel cover 62 with different openings to adjust the release speed, and the release element 6 can be replaced with a porous material as a whole to suit different release requirements.
  • the sustained release device 1 includes: a connection mechanism, two expansion mechanisms and two release mechanisms.
  • the connecting mechanism includes: two connecting beams 2, specifically a first connecting beam 21 and a second connecting beam 22 arranged longitudinally side by side, the first connecting beam 21 and the second connecting beam 22 half surround the lower end of the nasal septum 91, and the first connecting beam 21 is a C-shaped structure, which consists of a first intermediate portion 213 located on the lower side of the nasal septum 91 and two first connecting arms 214 located on both sides of the nasal septum 91.
  • the two first connecting arms 214 are inserted into the two nasal passages 95 from both sides of the nasal septum 91, and are respectively integrally connected to the expansion mechanisms symmetrically arranged in the two nasal passages 95;
  • the second middle portion 223 on the lower side of the nasal septum 91 and the two second connecting arms 224 on both sides of the nasal septum 91 are formed. It is detachably connected to the expansion mechanism symmetrically arranged in the two nasal passages 95 in a plug-in manner.
  • the connecting mechanism is provided with a second connecting beam 22 to supplement the clamping force.
  • the second connecting beam 22 applies a clamping force to the nasal septum 91 through two parts: one is that the plugs 243 arranged at the ends of the two second connecting arms 224 transmit the clamping force to the annular elastic force through the first elastic support spokes 71
  • the expansion arm 3 is then applied to the nasal septum 91 by the outer main surface 35 of the elastic expansion arm 3 close to the nasal septum 91;
  • the protrusions 242 fit with both sides of the nasal septum 91 and apply a clamping force to the nasal septum 91; as an optimization, the two first connecting arms 214 of the first connecting beam 21 can be provided with protrusions 242 with the same function.
  • the ends of the two second connecting arms 224 of the second connecting beam 22 are provided with plugs 243 , and the plugs 243 are inserted into the insertion holes 77 provided at the roots of the first elastic support spokes 71 to realize Plug-in fixing
  • the plug 243 is a structure with wide ends and a narrow middle, which includes: a cap 2431, a post 2432 and a handle 2433; wherein, the maximum width of the cap 2431 and the handle 2433 is greater than the maximum width of the post 2432; installation Afterwards, the socket 77 surrounds the post 2432 and engages closely with it.
  • the cap 2431 and the handle 2433 are located on the outer sides of the two ends of the socket 77 respectively, and the maximum width of the two is larger than the maximum width of the inner cavity of the socket 77, so that the plug 243 cannot
  • the inner cavity of the column 2432 and the socket 77 is a quadrangular prism structure, and the two are tightly engaged to prevent the expansion mechanism from rotating around the plug 243; as an optimization, the two first connecting arms 214 of the first connecting beam 21
  • the same plug 243 can be provided at the end of the 243 and connected to the elastic expansion arm 3 or the elastic support spoke 7 in a plug-in manner.
  • the two first connecting arms 214 of the first connecting beam 21 can be symmetrically provided with widened portions 241, and the width of the surface of the first connecting arm 214 toward the side of the nasal septum 91 is increased at the widened portion 241,
  • the two widened parts 241 fit on both sides of the nasal septum 91 and apply a clamping force to the nasal septum 91;
  • the two second connecting arms 224 of the second connecting beam 22 can be symmetrically set with widened parts 241, and the width of the surface of the second connecting arm 224 toward the side of the nasal septum 91 increases at the widened portion 241, and the two widened portions 241 fit both sides of the nasal septum 91 and add a clamping force to the nasal septum 91;
  • the widened portion 241 and the protrusion 242 can be merged into the same part.
  • each expansion mechanism includes: an elastic expansion arm 3 and two elastic support spokes 7 .
  • the elastic expansion arm 3 is an annular structure, which is connected with the end of the connecting arm 24 , and a pair of surfaces of the elastic expansion arm 3 parallel to the axis 97 of the nasal passage are its main surface and the largest surface , the pair of main surfaces are the inner main surface 34 and the outer main surface 35, the surface of the elastic expansion arm 3 perpendicular to the nasal passage axis 97 is the subsurface, and the width of the subsurface is smaller than the width of the main surface to reduce breathing resistance;
  • the outer major surface 35 fits the inner wall 96 of the nasal passage so that it can apply the expansion force from the elastic expansion arms 3 and the elastic support spokes 7 to the nasal passage 95 , and can also apply the clamping force from the second connecting beam 22 to the nasal septum 91 .
  • the elastic expansion arm 3 When wearing, the elastic expansion arm 3 is compressed by the inner wall 96 of the nasal passage, and its resilience prompts it to exert an all-round expansion force on the nasal passage 95. The force holds the sustained release device 1 within the nasal passage 95 .
  • the annular elastic expansion arm 3 can expand the nasal passage in all directions, and can increase the contact area of the two to reduce the pressure of the expansion mechanism on the inner wall of the nasal passage, thereby improving comfort.
  • the two elastic support spokes 7 are the first elastic support spokes 71 and the second elastic support spokes 72 , both of which are belt-like structures and are placed in the elastic expansion arms 3 at intervals, that is, One end of the first elastic support spoke 71 and the second elastic support spoke 72 is connected to the inner main surface 34 of the elastic expansion arm 3 close to the nasal septum 91, and the other end is connected to the inner main surface 34 of the elastic expansion arm 3 close to the nasal alar 92, so as to ensure its The resilient force is applied to the nose 92 in a targeted manner.
  • each release mechanism is symmetrically arranged, each release mechanism is correspondingly arranged in each expansion mechanism, and each release mechanism includes: a fixed tube 5 and a release element 6;
  • the inner cavity of the fixing tube 5 is a quadrangular prism structure, which is fixed on the second elastic support spokes 72, and the fixing tube 5 surrounds and fixes the release element 6; as an optimization, the fixing tube 5 can also be arranged in The support spokes 71 are arranged on the inner main surface 34 of the elastic expansion arm 3 .
  • the release element 6 is a structure with wide ends and a narrow middle, and both ends and the middle are quadrangular prism structures.
  • the release element 6 When worn, the release element 6 is fixed on the fixing tube 5,
  • the fixing tube 5 surrounds the middle part of the release element 6 and is tightly engaged with it.
  • the middle part of the release element 6 and the quadrangular prism structure of the inner cavity of the fixing tube can prevent the release element 6 from rotating.
  • its maximum width is greater than the maximum width of the inner cavity of the fixed tube 5, so that the release element 6 cannot be detached from the fixed tube 5; when worn, the release element 6 is located in the nasal passage 95;
  • the releasing element 6 is made of porous material, which can absorb and preserve the liquid compound. Its wider ends and porous surface are conducive to the volatilization of the compound, and it is also conducive to the inhalation airflow of the nasal passage to take away tiny compound droplets, especially , the porous material is capable of releasing non-volatile liquid compounds in the form of tiny droplets.
  • the two ends of the release element 6 made of the porous material are provided with bumps 65 to further expand its surface area and increase the speed of releasing the compound.

Abstract

一种在鼻通道内缓慢释放化合物的缓释装置，该装置包括：一个连接机构、两个扩张机构和两个释放机构；连接机构的两端分别一体式或可拆卸式地连接对称设置在两侧鼻通道内的两个扩张机构；两个释放机构对称设置，每个释放机构对应地设置在每个扩张机构内；该缓释装置方便携带，能够在鼻通道内缓慢释放化合物，并同步扩张鼻通道来保证顺畅呼吸，兼顾了功能性、实用性和舒适性。

Description

一种在鼻通道内缓慢释放化合物的缓释装置 技术领域
本发明属于医疗器械技术领域，涉及一种在鼻通道内缓慢释放化合物的缓释装置。
背景技术
人们常用鼻喷雾剂来治疗过敏性鼻炎和鼻通道阻塞，此类药物的活性成分会刺激鼻内的激素受体，使血管收缩，缓解鼻粘膜充血和鼻塞。由于短时间有大剂量的药物直接与鼻粘膜接触，会导致所述受体的数量迅速减少，一段时间以后，鼻粘膜会更加充血发炎，并导致血管变脆、易流鼻血。缓释技术能够避免药物对鼻粘膜的瞬间冲击，从而减弱乃至避免上述副作用的发生。另外，使用精油来改善恶心、过敏、失眠等病症已经广为人知，传统的熏香器多放置于室内，体积较大、不便携带，便携的鼻部缓释装置则能够帮助人们随时随地使用精油等芳香族化合物。现有技术提供了多种便携鼻夹来帮助人们在鼻通道中缓慢释放化合物，但现有鼻夹往往只能释放特定种类或状态的化合物，缺乏通用性，而且在释放效果和通气性等方面也有很大的局限性：
1.一类鼻夹在材料中掺入了可挥发性的芳香族化合物，此类鼻夹结构简单、容易佩戴，但会导致芳香族化合物直接接触和刺激鼻通道内壁；并且其所携带的芳香族化合物无法更换，另外，此类鼻夹不具有扩张鼻通道的功能，因此会在一定程度上阻碍呼吸；
2.一类鼻夹的内部设置有可开闭的空腔，将化合物放置于其中，通过空腔上的开口向鼻通道内释放化合物；但是，由于设置了空腔，此类鼻夹较为粗大，且不具有扩张鼻通道的功能，因此会在一定程度上阻碍呼吸；另外，由于空腔的开闭装置细小复杂，可靠性较低，一旦失效，可能造成吸入风险；
3.一类鼻夹的末端设置有圆管，在圆管中放置有固态的芳香族化合物，该固态化合物通过圆管中部收窄的部位加以固定；但是，此类鼻夹无法释放液态化合物；而且由于固态芳香族化合物并不坚硬，其固定方式可靠性不足，可能造成吸入风险；另外，此类鼻夹不具备扩张鼻通道的功能，因此会在一定程度上阻碍呼吸；
4.一类鼻夹设置有用来扩张鼻通道的扩张元件和固定在扩张元件上用来释放化合物的释放元件；此类鼻夹的通气性好于其他鼻夹，但其扩张元件与鼻通道的内壁接触面积较小，对鼻通道内壁的压强较大，容易造成不适，也难以全方位地扩张鼻通道；另外，其扩张元件未设置弹性支撑辐条，因此在扩张的强度和均衡性上存在不足，也难以对鼻通道的特定部位进行有针对性的扩张；再有，其释放元件仅能容纳少量特定状态和种类的化合物，且开闭装置细小复杂、可靠性不足；
5.一类鼻夹兼具过滤和释放功能，其包括一对通过连接带连接在一起的圆柱形容器，该圆柱形容器内部设有过滤器和能够吸收液态药物的吸收垫圈，该吸收垫圈可以向吸入气流中释放药物；但是，此类鼻夹无法释放固态化合物；且吸入气体要途经过滤器和吸收垫，呼吸阻力很大，因此其通用性较低，仅适用于特定的情境。
发明内容
为解决现有技术存在的上述缺陷，本发明提出了一种在鼻通道内缓慢释放化合物的缓释装置，所述缓释装置包括：一个连接机构、两个扩张机构和两个释放机构；所述连接机构的两端分别一体式或可拆卸式地连接对称设置在两侧鼻通道内的两个扩张机构；所述两个释放机构对称设置，每个释放机构对应地设置在每个扩张机构内；
所述连接机构包括至少一个连接梁，所述连接梁半环绕于鼻中隔的下端，其包括：位于鼻中隔下侧的中间部和对称设置于鼻中隔两侧的两个连接臂；中间部位于两个连接臂之 间；两个连接臂分别连接对称设置在两个鼻通道内的两个扩张机构；
所述释放机构包括：至少一个固定管和至少一个释放元件；
所述固定管为管状结构，其设置在扩张机构上；所述释放元件为两端宽且中部窄的结构，佩戴时，释放元件固定在固定管内，固定管环绕于释放元件较细的中部，并与其紧密咬合，释放元件的两端位于固定管两端的外侧，释放元件两端的最大宽度大于固定管内腔的最大宽度；所述释放元件能够容纳一定量的化合物，并允许所容纳的化合物在鼻通道内缓慢释放，佩戴时，至少部分释放元件位于鼻通道内。
作为上述技术方案的改进之一，所述扩张机构包括：一个弹性扩张臂；该弹性扩张臂为环状闭合结构，其与一个连接臂的端部连接；固定管设置在弹性扩张臂的内侧主表面，释放元件套设在固定管内。
作为上述技术方案的改进之一，所述连接梁的两个连接臂对称地设置有加宽部，且连接臂朝向鼻中隔一侧的表面的宽度在加宽部增大；所述两个加宽部贴合鼻中隔的两侧，并向鼻中隔施加包夹力。
作为上述技术方案的改进之一，所述扩张机构包括：一个弹性扩张臂和至少一个弹性支撑辐条；
所述弹性扩张臂为环状闭合结构，其与一个连接臂的端部连接；弹性支撑辐条分叉并包括多个分支，每个分支的一端连接于弹性支撑辐条的主干部位，其另一端固定在弹性扩张臂上；固定管设置于弹性支撑辐条上，释放元件套设在固定管内。
作为上述技术方案的改进之一，所述弹性支撑辐条、固定管和释放元件位于弹性扩张臂的上方，形成倒置的碗状结构。
作为上述技术方案的改进之一，所述扩张机构包括：一个弹性扩张臂和至少一个弹性支撑辐条；
所述弹性扩张臂为环状闭合结构，其与一个连接臂的端部连接；弹性支撑辐条为带状结构，其两端连接于弹性扩张臂。
作为上述技术方案的改进之一，所述连接机构包括纵向并列设置的第一连接梁和第二连接梁；第一连接梁和第二连接梁均半环绕于鼻中隔的下端。
作为上述技术方案的改进之一，所述第二连接梁的两个第二连接臂对称设置有朝向佩戴者的鼻中隔的凸起；所述凸起贴合鼻中隔的两侧，并向鼻中隔施加包夹力。
作为上述技术方案的改进之一，所述第二连接梁的两个第二连接臂的端部设有插头，所述插头插入设置于第一弹性支撑辐条根部的插孔中，所述插头为两端宽且中部窄的结构，实现插接式固定。
作为上述技术方案的改进之一，所述扩张机构包括：一个弹性扩张臂、一个鼻通道接合元件和至少一个弹性支撑辐条；
弹性扩张臂为可弹性压缩的开口带状结构，其与一个连接臂的端部连接，弹性扩张臂的外侧主表面可部分地或全部地贴合鼻通道内壁，使其既能够向鼻翼施加来自弹性扩张臂和弹性支撑辐条的扩张力，也能够向鼻中隔施加来自连接梁的包夹力；
鼻通道接合元件为片状结构，其与弹性扩张臂连接,并使扩张机构保持开口结构；佩戴时，鼻通道接合元件位于鼻翼的内侧，其外主表面与鼻翼的内壁贴合，并向鼻翼施加来自弹性扩张臂和弹性支撑辐条的扩张力；
弹性支撑辐条为可弹性压缩的带状或条状结构，其两端连接于弹性扩张臂或鼻通道接合元件。
作为上述技术方案的改进之一，所述弹性扩张臂与鼻通道接合元件融合为一体。
作为上述技术方案的改进之一，所述弹性扩张臂垂直于鼻通道轴线的横截面为V形结构或C形结构，其包括：弯曲部、近臂和远臂；
所述弯曲部的一端连接近臂，其另一端连接远臂，佩戴时，近臂靠近鼻中隔，远臂靠近鼻翼，弯曲部靠近鼻梁或鼻底。
作为上述技术方案的改进之一，所述弹性扩张臂与鼻通道内壁贴合的部位，其端部向鼻通道内侧弯曲；所述鼻通道接合元件的端部向鼻通道内侧弯曲。
作为上述技术方案的改进之一，所述弹性支撑辐条分叉并具有多个分支，所述每个分支的一端连接于弹性支撑辐条的主干部位，其另一端固定在弹性扩张臂或鼻通道接合元件上。
作为上述技术方案的改进之一，所述连接梁向鼻中隔施加包夹力，该包夹力由连接梁的两个连接臂直接施加于鼻中隔的下端，或该包夹力由连接梁的两个连接臂传导至对应的扩张机构后，由对应的扩张机构施加于鼻中隔的下端。
作为上述技术方案的改进之一，连接梁的中间部的平均横截面积较连接臂的平均横截面积更大。
作为上述技术方案的改进之一，所述释放元件包括：药桶，以及连接并覆盖于药桶两端的桶盖和桶底；桶盖的最大直径大于药桶的最大直径；桶底的最大直径大于药桶的最大直径；
所述药桶为中空的管状结构，其内部容纳有化合物，所述桶盖和桶底上设置有至少一个开口，使化合物通过所述开口向鼻通道排出。
作为上述技术方案的改进之一，所述药桶内设置有多孔材料制成的吸纳块。
作为上述技术方案的改进之一，所述释放元件采用多孔材料制成。
作为上述技术方案的改进之一，所述释放元件的外表面设置有隆起物。
本发明与现有技术相比的有益效果是：
1、本发明的缓释装置的扩张机构采用闭合结构或开口结构，提升了缓释装置的功能和适用性，也提升了其具体实施方式的多样性。
2、除鼻通道接合元件外，弹性扩张臂的外侧主表面也可以贴合鼻通道内壁，增加了扩张机构与鼻通道内壁的接触面积，有利于全方位的扩张鼻通道，并减小扩张机构对鼻通道内壁的压强，提升舒适性。
3、采用至少一个弹性支撑辐条，保证了扩张的强度和平衡性，并能够对鼻通道的特定部位进行有针对性的扩张。
4、释放元件不接触鼻通道内壁，避免了其容纳的化合物接触和刺激鼻通道内壁。
5、释放元件采用柱体结构，其横截面面积较小，因此具有较小的空气阻力，并且通过增加释放元件沿鼻通道轴线方向的长度，可以有效增加其容量，且不增大空气阻力。
6、释放元件的固定方式简单、可靠，避免了脱落和吸入风险。
7、通过替换不同的释放元件，可以使之适合释放不同状态和种类的化合物，特别是可以释放非挥发性的液态化合物。
8、通过替换不同的释放元件或其部件，可以调整其释放化合物的速度。
附图说明
图1A为人类鼻部的侧视图；
图1B为人类鼻部的侧视剖面图；
图1C为人类鼻部自下而上的俯视图；
图2为本发明的一种在鼻通道内缓慢释放化合物并扩张鼻通道的缓释装置的第一个优选实施例的结构示意图；
图3为图2的本发明的一种在鼻通道内缓慢释放化合物并扩张鼻通道的缓释装置的第 一个优选实施例的俯视图；
图4为图2的本发明的一种在鼻通道内缓慢释放化合物并扩张鼻通道的缓释装置的第一个优选实施例的一个方向的侧视图；
图5为图2的本发明的一种在鼻通道内缓慢释放化合物并扩张鼻通道的缓释装置的第一个优选实施例的另一个方向的侧视图；
图6为图2的本发明的一种在鼻通道内缓慢释放化合物并扩张鼻通道的缓释装置的第一个优选实施例设置一个弹性支撑辐条的结构示意图；
图7为图2的本发明的一种在鼻通道内缓慢释放化合物并扩张鼻通道的缓释装置的第一个优选实施例的释放元件的侧视剖面图；
图8为图2的本发明的一种在鼻通道内缓慢释放化合物并扩张鼻通道的缓释装置的第一个优选实施例安装在使用者的鼻部的自下而上俯视图；
图9为图2的本发明的一种在鼻通道内缓慢释放化合物并扩张鼻通道的缓释装置的第一个优选实施例安装在使用者的鼻部的侧视图；
图10为本发明的一种在鼻通道内缓慢释放化合物并扩张鼻通道的缓释装置的第二个优选实施例的结构示意图；
图11为图10的本发明的一种在鼻通道内缓慢释放化合物并扩张鼻通道的缓释装置的第二个优选实施例的俯视图；
图12为图10的本发明的一种在鼻通道内缓慢释放化合物并扩张鼻通道的缓释装置的第二个优选实施例设置分叉的弹性支撑辐条的结构图；
图13为图10的本发明的一种在鼻通道内缓慢释放化合物并扩张鼻通道的缓释装置的第二个优选实施例的释放元件的侧视剖面图；
图14为本发明的一种在鼻通道内缓慢释放化合物并扩张鼻通道的缓释装置的第三个优选实施例的结构示意图；
图15为图14的本发明的一种在鼻通道内缓慢释放化合物并扩张鼻通道的缓释装置的第三个优选实施例的俯视图；
图16为图14的本发明的一种在鼻通道内缓慢释放化合物并扩张鼻通道的缓释装置的第三个优选实施例的侧视图；
图17A为图14的本发明的一种在鼻通道内缓慢释放化合物并扩张鼻通道的缓释装置的第三个优选实施例的释放元件的侧视剖面图；
图17B为图14的本发明的一种在鼻通道内缓慢释放化合物并扩张鼻通道的缓释装置的第三个优选实施例的释放元件的侧视剖面图，所述释放元件的两端设置有凸起；
图18A为本发明的一种在鼻通道内缓慢释放化合物并扩张鼻通道的缓释装置的其他实施例的弹性扩张臂与鼻通道接合元件的一种位置关系的俯视图；
图18B为本发明的一种在鼻通道内缓慢释放化合物并扩张鼻通道的缓释装置的其他实施例的弹性扩张臂与鼻通道接合元件的另一种位置关系的俯视图；
附图标记：
1、缓释装置                         2、连接梁
3、弹性扩张臂                       4、鼻通道接合元件
5、固定管                           6、释放元件
7、弹性支撑辐条
11、鼻部的前方                      12、鼻部的后方
13、鼻部的上方                      14、鼻部的下方
21、第一连接梁                      22、第二连接梁
23、中间部                          24、连接臂
31、弯曲部                          32、近臂
33、远臂                            34、内侧主表面
35、外侧主表面                        36、钩状物
41、内主表面                          42、外主表面
61、药桶                              62、桶盖
63、桶底                              64、内容物
65、隆起物
71、第一弹性支撑辐条                  72、第二弹性支撑辐条
73、第一分支                          74、第二分支
75、第三分支                          76、第四分支
77、插孔
91、鼻中隔                            92、鼻翼
93、鼻梁                              94、鼻孔
95、鼻通道                            96、鼻通道内壁
97、鼻通道轴线                        98、鼻腔
99、鼻底
213、第一中间部                       214、第一连接臂
223、第二中间部                       224、第二连接臂
241、加宽部                           242、凸起
243、插头
611、螺口                             612、卡孔
621、第一孔                           622、柱状凸起
623、螺纹                             624、半球状凸起
631、第二孔                           641、吸纳块
642、固态化合物
2431、帽                              2432、柱
2433、柄
具体实施方式
现结合附图对本发明作进一步的描述。
如图2、10和14所示，本发明的缓释装置1中，除连接梁2以外，其余部件均对称设置于两个鼻通道95内，因此，本发明对缓释装置1的说明，除连接梁2以外，其余部件均为位于一个鼻通道内的数量和结构。
如图1A所示，本发明所述鼻部的各个方向为：鼻部的前方11、鼻部的后方12、鼻部的上方13、鼻部的下方14。
如图1B所示，在鼻通道95内，物体靠近鼻通道轴线97一侧为“内侧”、远离鼻通道轴线97的一侧为“外侧”。
本发明所述的术语“连接”是指两个有形物体一体式地连在一起，或通过连接件可拆卸地连在一起，连接方式包括但不限于：粘接、熔接、插接、螺扣连接、卡扣连接。
本发明所述的术语“轴线”指管状物或柱状物的中心对称轴线。对于非标准的管状物或柱状物，可将其近似为标准管状物或柱状物后，将所述标准管状物或柱状物的轴线作为其近似轴线。例如，图1B描述了鼻通道轴线97。
本发明所述的术语“横截面”指所述管状物或柱状物垂直于其轴线的截面。
本发明所述的术语“化合物”并非严格的化学定义，而应包括固态和液态的纯净物、化合物和混合物，以及适用于本发明的其他物质形式或组合，所述化合物可以是药用或非药用的，包括但不限于药物和芳香族物质。
本发明所述的术语“闭合结构”是由n(n为正整数)条线段或弧组成的闭合平面图形，例如：圆形、椭圆形、多边形；本发明所述的术语“开口结构”是指在封闭图形上设置一处开口的平面图形，例如：C形、V形、l形、弧形。
本发明所述的术语“管状结构”指内部具有沿轴线方向贯通的空腔的柱状结构，所述柱状结构包括但不限于圆柱和棱柱。
如图1A、1B和1C所示，本发明的缓释装置1应用于人类的鼻部9。鼻部9为视觉可见的面部突出部位，包括：鼻中隔91、鼻翼92、鼻梁93和鼻底99，以及它们围绕成的两个鼻通道95。两个鼻通道95的出口为两个鼻孔94。鼻通道内壁96由上述围绕鼻通道95的各部位的内侧表面构成。本发明中，鼻通道95仅限于由鼻部9包含的鼻前庭，不包括鼻腔98。
如图2所示，本发明提供了一种在鼻通道95内缓慢释放化合物并扩张鼻通道95的缓释装置1，其包括：一个连接机构、两个扩张机构和两个释放机构；
连接机构的两端分别一体式或可拆卸式地连接对称设置在两侧鼻通道95内的两个扩张机构；两个释放机构对称设置，每个释放机构对应地设置在每个扩张机构内。
所述扩张机构用于扩张鼻通道95，所述释放机构用于容纳和释放化合物。
如图2、4、5和9所示，所述连接机构包括至少一个连接梁2，所述连接梁2半环绕于鼻中隔91的下端，其包括：位于鼻中隔91下侧的中间部23和位于鼻中隔91两侧的两个连接臂24；中间部23的两端分别连接两个连接臂24；连接梁2的两个连接臂24由鼻中隔91的两侧插入两个鼻通道95内，两个连接臂24分别连接于对称设置在两个鼻通道95内的两个扩张机构；优选的，所述连接梁2为U形或C形结构，其中C形结构更有利于连接臂24的端部向鼻中隔91施加包夹力。
优选的，所述连接梁2还为缓释装置1提供固定功能，其两个连接臂24的最小间距小于该处鼻中隔91的宽度，使其向鼻中隔91施加包夹力，所述包夹力由连接梁2的两个连接臂24直接施加于鼻中隔91的两侧，或由连接梁2的两个连接臂24传导至对应的扩张机构后，由弹性扩张臂3施加于鼻中隔91的两侧；上述包夹力使缓释装置1能够包夹并固定在鼻中隔91。
如图2、4和5所示，优选的，连接梁2的中间部23的平均横截面积大于连接臂24的平均横截面积，使中间部23较连接臂24更粗，从而强化连接梁2保持自身形状的能力，进而提升其向鼻中隔91施加包夹力的能力。
如图14、15和16所示，在其他具体实施例中，缓释装置1的连接机构中的连接梁2包括：第一连接梁21和第二连接梁22，由于第一连接梁21与扩张机构一体式地连接并采用相同材料，而该材料不能支持第一连接梁21提供充分的包夹力，因此，在与第一连接梁21纵向并列的位置还设置有第二连接梁22，并通过第二连接梁22来补充对鼻中隔91的包夹力。
如图14和16所示，在其他具体实施例中，所述连接梁2的两个连接臂24设置有朝向鼻中隔91的凸起242，所述凸起242贴合鼻中隔91的两侧，并向鼻中隔施加包夹力；当凸起242提供包夹和固定功能时，该连接梁2的两个连接臂24的末端能够在更深入鼻通道95的位置连接扩张机构，从而有助于将扩张机构和释放机构设置于更加深入鼻通道95的位置。
如图10所示，在其他具体实施例中，两个连接臂24设有加宽部241，连接机构通过所述加宽部241向鼻中隔91施加包夹力；且连接臂24朝向鼻中隔91一侧的表面的宽度在加宽部241增大，以增大加宽部241与鼻中隔91的贴合面积，从而减小连接梁2对鼻中隔91的压强，以提升舒适度。
当连接梁2同时设置有加宽部241和凸起242时，二者可以合并为同一部位，该部位兼具加宽部241和凸起242的特征。
如图14、15和16所示，在其他具体实施例中，所述连接梁2的两个连接臂24的端部设置有插头243，插头243为两端宽且中部窄的结构，并通过插接方式将连接梁2固定在扩张机构上；
具体地，如图16所示，所述插头243插入设置于弹性扩张臂3或弹性支撑辐条7上的 插孔77中，实现插接式固定；所述插头243为两端宽且中部窄的结构，其包括：帽2431、柱2432和柄2433，所述插孔77与柱2432紧密咬合，柄2433的最大宽度大于柱2432的最大宽度，且帽2431的最大宽度大于柱2432的最大宽度；同时，柄2433的最大宽度大于插孔77内腔的最大宽度，且帽2431的最大宽度大于插孔77内腔的最大宽度；使插头243无法脱出；优选的，柱2432和插孔77的内腔可设置为棱柱状，以避免扩张机构绕插头243发生旋转。
如图2所示，所述两个扩张机构对称地连接在所述连接机构上，每个扩张机构包括：一个弹性扩张臂3、一个鼻通道接合元件4和至少一个弹性支撑辐条7；
如图2、4、5和9所示，所述鼻通道接合元件4为片状结构，其与弹性扩张臂3连接，佩戴时，鼻通道接合元件4位于鼻翼92的内侧并向鼻翼92施加扩张力；鼻通道接合元件4平行于鼻通道轴线97的一对表面是其主表面和最大表面，所述一对主表面具体为内主表面41和外主表面42，其宽度通常大于弹性扩张臂3的同侧表面的宽度；外主表面42贴合鼻翼92的内壁，并向鼻翼92施加来自弹性扩张臂3和弹性支撑辐条7的扩张力，鼻通道接合元件4垂直于鼻通道轴线97的表面为其次表面，所述次表面的宽度小于主表面的宽度，以减小呼吸阻力。
如图2、3、4、6和8所示，所述弹性扩张臂3为可弹性压缩的开口带状结构，例如：C形、V形、l形或弧形的带状结构，其连接于连接臂24和鼻通道接合元件4；弹性扩张臂3平行于鼻通道轴线97的一对表面是其主表面和最大表面，所述一对主表面具体为内侧主表面34和外侧主表面35，弹性扩张臂3垂直于鼻通道轴线97的表面为其次表面，次表面的宽度小于主表面的宽度，以减小呼吸阻力；如图8所示，弹性扩张臂3的外侧主表面35部分地或全部地贴合鼻通道内壁96，使其既能够向鼻翼92施加来自弹性扩张臂3和弹性支撑辐条7的扩张力，也能够向鼻中隔91施加来自连接梁2的包夹力；由于弹性扩张臂3为开口结构，所以其对不同形状和尺寸的鼻通道适应性较强，特别适用于因鼻中隔偏曲症导致的左右鼻通道尺寸不同的使用者，从而提升用户体验感和舒适性，并符合人体工学设计。
如图6所示，当鼻通道接合元件4的宽度等于或小于弹性扩张臂3的宽度，且二者的同侧主表面平滑连接并融合为同一表面时，也即：内侧主表面34和内主表面41融合为一个表面、外侧主表面35和外主表面42融合为一个表面，此时弹性扩张臂3和鼻通道接合元件4融合为一体，鼻通道接合元件4的功能完全由弹性扩张臂3替代，此时扩张机构不再包括鼻通道接合元件4，仅包括弹性扩张臂3和弹性支撑辐条7。
优选的，所述弹性扩张臂3与鼻通道内壁96贴合的部位，其端部向鼻通道95内侧弯曲，例如，如图6所示，弹性扩张臂3的近臂32和远臂33的末端为钩状物36，所述钩状物36可以柔性的接触鼻通道内壁96；所述鼻通道接合元件4的端部向鼻通道95内侧弯曲。
优选的，如图2、3、4、6和8所示，所述弹性扩张臂3垂直于鼻通道轴线97的横截面为V形或C形结构，其包括：弯曲部31、近臂32和远臂33；
所述弯曲部31的一端连接近臂32，其另一端连接远臂31，佩戴时，近臂32靠近鼻中隔91，远臂33靠近鼻翼92，弯曲部31靠近鼻梁93或鼻底99，也即弹性扩张臂3的开口可以朝向鼻梁93也可以朝向鼻底99；弹性扩张臂3的外侧主表面35与鼻通道内壁96贴合，如图8所示，佩戴时，弹性扩张臂3被鼻通道内壁96压缩，远臂33和近臂32相互靠近，弯曲部31的回弹力促使远臂33和鼻通道接合元件4向鼻翼92施加扩张力，从而扩张鼻通道，同时，弹性扩张臂3和鼻通道接合元件4与鼻通道内壁96紧密贴合，其相互作用力将缓释装置1固定在鼻通道95内。
如图18A所示，在其他具体实施例中，弹性扩张臂3为弧形或l形的开口带状结构，其一端连接于连接臂24的端部，其另一端连接于鼻通道接合元件4的内主表面41，弹性扩张臂3与鼻通道接合元件4未融合为一体，佩戴时，鼻通道接合元件4的外主表面42贴合 鼻通道内壁96，但弹性扩张臂3不贴合鼻通道内壁96，另外，由于扩张机构与鼻通道内壁96贴合面积较小，因此未设置弹性支撑辐条来提供多点支撑。
如图18B所示，在其他具体实施例中，弹性扩张臂3为弧形或l形的开口带状结构，其一端连接于连接臂24的端部，其另一端连接于鼻通道接合元件4的一侧次表面，佩戴时，鼻通道接合元件4的外主表面42贴合鼻通道内壁96，但弹性扩张臂3不贴合鼻通道内壁96，由于弹性扩张臂3与鼻通道接合元件4的对应主表面未平滑连接也未构成一个表面，因此二者未融合为一体。
如图6所示，弹性支撑辐条7为可弹性压缩的带状或条状结构，其两端连接于弹性扩张臂3或鼻通道接合元件4，佩戴时，弹性支撑辐条7将自身压缩后的回弹力施加于弹性扩张臂3和/或鼻通道接合元件4；弹性支撑辐条7能够提升扩张机构的扩张力，同时，其也提升了扩张的平衡性，因为弹性扩张臂3为开口结构，越靠近端部其回弹力越弱，所述弹性支撑辐条7能够对弹性扩张臂3和鼻通道接合元件4的特定位置提供有针对性的支撑，从而保证了扩张机构对鼻通道95扩张的平衡性；
如图2、3和8所示，优选的，弹性支撑辐条7分叉并包括多个分支，具体为：第一分支73、第二分支74、第三分支75和第四分支76，每个分支的一端连接于弹性支撑辐条7的主干部位，其另一端固定在弹性扩张臂3或鼻通道接合元件4上；弹性支撑辐条7的多个分支使其具有更强的回弹力，从而进一步提升了扩张强度，同时，其多个分支也提供了更多的支撑点，也进一步提升了扩张的针对性和平衡性。
如图10和11所示，在其他具体实施例中，扩张机构包括：一个弹性扩张臂3；所述弹性扩张臂3为环状闭合结构，其外侧主表面35贴合鼻通道内壁96；佩戴时，弹性扩张臂3被鼻通道内壁96压缩，其回弹力促使其对鼻通道95的各个方向施加扩张力；同时，弹性扩张臂3与鼻通道内壁96紧密贴合，二者的相互作用力将缓释装置1固定在鼻通道95内。环状的弹性扩张臂3可以全方位的扩张鼻通道，并能够增大扩张机构与鼻通道内壁96的接触面积，从而减小扩张机构对鼻通道内壁96的压强，以提升舒适性。
如图12所示，在其他具体实施例中，扩张机构包括：一个弹性扩张臂3和至少一个弹性支撑辐条7；所述弹性扩张臂3为环状结构，弹性支撑辐条7分叉并包括多个分支，具体为：第一分支73、第二分支74和第三分支75，每个分支的一端连接于弹性支撑辐条7的主干部位，其另一端固定在弹性扩张臂3上，佩戴时，弹性支撑辐条7将自身压缩后的回弹力施加于弹性扩张臂3；优选的，弹性支撑辐条7以及固定于弹性支撑辐条7上的固定管5和释放元件6位于弹性扩张臂3的上方，形成倒置的碗形结构，有利于释放机构向呼吸道更深处释放化合物。
如图14和15所示，在其他具体实施例中，扩张机构包括：一个弹性扩张臂3和至少一个弹性支撑辐条7；所述弹性扩张臂3为环状闭合结构，弹性支撑辐条7为可弹性压缩的带状或条状结构，其两端连接于弹性扩张臂3。
如图2所示，所述两个释放机构对称设置，每个释放机构对应地设置在每个扩张机构内，每个释放机构包括：至少一个固定管5和至少一个释放元件6；
如图2所示，所述固定管5为管状结构，其用于固定释放元件6，固定管5设置在弹性扩张臂3的开口方向处，并通过第一分支73、第二分支74、第三分支75和第四分支76，将固定管5固定在弹性支撑辐条7的主干部位；如图10和14所示，在其他具体实施例中，所述固定管5固定于弹性扩张臂3的内侧或鼻通道接合元件4的内侧，具体地，如图10所示的固定管5固定在环状的弹性扩张臂3的内侧；如图14所示，在其他具体实施例中，四棱柱形固定管5固定在第二弹性支撑辐条72上。作为优化，所述缓释装置1设置多个固定管5和释放元件6，以增大化合物的容量或提升化合物的释放速度。
如图2、10和14所示，所述释放元件6为两端宽且中部窄的结构，佩戴时，所述释放 元件6固定在固定管5上，固定管5环绕于释放元件6的较细的中部，并与其紧密咬合，释放元件6的两端位于固定管5两端的外侧，其最大宽度大于固定管5的内腔的最大宽度，使释放元件6无法从固定管5上脱离；所述释放元件6能够容纳一定量的化合物并允许化合物在鼻通道95内缓慢释放，佩戴时，所述的释放元件6至少部分的位于鼻通道95内。
所述释放机构具有以下优点：一是固定方式简单、可靠；二是横截面的面积小、呼吸阻力小；三是可以根据需要在鼻通道轴线方向上增加其长度、提升其容量，且不会增大呼吸阻力；四是通过替换不同类型的释放元件6，可以使之适用于不同的化合物或提供不同的释放速度；五是可以方便的替换释放元件6容纳的化合物；六是可以通过调整释放元件6的开口数量和开口大小来调整化合物的释放速度。
如图14、17A、17B所示，在其他具体实施例中，所述释放元件6的材料为多孔材料，用于吸纳和保存液态化合物，其多孔的表面特别有利于化合物的挥发，还有利于鼻通道的吸入气流带走微小的化合物液滴，因此所述多孔材料不但能够释放挥发性液态化合物，还能够以微小液滴的形式释放非挥发性液态化合物。如图17B所示，作为优化，所述多孔材料制成的释放元件6的两端的表面设有隆起物65，以进一步扩大其表面积，提升释放速度。
如图2、7、10和13所示，在其他具体实施例中，所述释放元件6包括：药桶61和连接并覆盖于药桶61两端的桶盖62和桶底63；
桶盖62和桶底63最大宽度大于药桶61的最大宽度；药桶61为中空的管状结构，其内部用于容纳固态和液态化合物，所述桶盖62和桶底63上至少设有一个开口让所述化合物通过所述开口排出。如图7所示，作为优化，所述药桶61内设置有多孔材料制成的吸纳块641，用于吸收和容纳液态化合物，避免液态化合物从开口流出，还能够通过其多孔的表面提升化合物的释放速度。
实施例1.
图2、3、4、5、6、7、8和9为本发明的第一个优选实施例，该缓释装置1包括：一个连接机构、两个扩张机构和两个释放机构。
如图2、4、5和9所示，所述连接机构包括：一个U形结构的连接梁2，所述连接梁2半环绕于鼻中隔91的下端，如图2所示，该连接梁2包括：位于鼻中隔91下侧的中间部23和位于鼻中隔91两侧的两个连接臂24，中间部23的两端分别连接两个连接臂24；佩戴时，两个连接臂24由鼻中隔91的两侧插入两个鼻通道95内，其分别一体式地连接于对称设置在两个鼻通道95内的两个弹性扩张臂3；两个连接臂24的最小间距小于该处鼻中隔91的宽度，使其向鼻中隔91施加包夹力，从而将缓释装置1固定于鼻中隔91；中间部23的平均横截面积大于连接臂24的平均横截面积，使中间部23较连接臂24更粗，以提升连接梁2保持原有形状的能力，进而强化所述包夹力。
作为优化，所述连接梁2的两个连接臂24可对称地设置加宽部241，且连接臂24朝向鼻中隔91一侧的表面的宽度在加宽部241增大；所述两个加宽部241贴合鼻中隔91的两侧，并向鼻中隔91加包夹力。
作为优化，所述连接梁2的两个连接臂24可对称设置朝向佩戴者的鼻中隔91的凸起242；所述凸起242贴合鼻中隔91的两侧，并向鼻中隔91施加包夹力。
作为优化，所述连接梁2的两个连接臂24的端部可设置插头243，所述插头243插入设置于弹性扩张臂3或支撑辐条上的插孔77中，所述插头243为两端宽且中部窄的结构，实现插接式固定。
如图2所示，两个扩张机构对称地连接在连接机构上，每个扩张机构包括：一个弹性扩张臂3、一个鼻通道接合元件4和一个弹性支撑辐条7。
如图2、4、5和9所示，鼻通道接合元件4为片状结构，其位于佩戴者的鼻翼92的内侧，鼻通道接合元件4连接于弹性扩张臂3的远臂33的端部，其平行于鼻通道轴线97的一 对表面是其主表面和最大表面，所述的一对主表面为内主表面41和外主表面42，外主表面42贴合鼻翼92的内壁，并由此向鼻翼92施加来自弹性扩张臂3和弹性支撑辐条7的扩张力，鼻通道接合元件4的主表面宽度大于远臂33的主表面宽度，从而更好地分散扩张机构对鼻翼92的扩张压强，以提升舒适性；鼻通道接合元件4垂直于鼻通道轴线97的表面为其次表面，次表面的宽度小于主表面的宽度，以减小空气阻力。
作为优化，所述鼻通道接合元件4的末端可向鼻通道95内侧弯曲，以避免其末端刺激鼻通道内壁96。
如图2和3所示，所述弹性扩张臂3与连接臂24和鼻通道接合元件4连接，其垂直于鼻通道轴线97的横截面为V形结构，该弹性扩张臂3包括：弯曲部31、近臂32和远臂33；所述弯曲部31的一端连接近臂32，其另一端连接远臂33；佩戴时，近臂32靠近鼻中隔91，远臂33靠近鼻翼92，弯曲部31靠近鼻梁93，如图1C和8所示，此时弹性扩张臂3的开口朝向鼻底99；作为优化，弹性扩张臂3的近臂32靠近鼻中隔91，远臂33靠近鼻翼92，弯曲部31靠近鼻底99，从而使弹性扩张臂3的开口朝向鼻梁93；弹性扩张臂3平行于鼻通道轴线97的一对表面是其主表面和最大表面，所述一对主表面为内侧主表面34和外侧主表面35，弹性扩张臂3垂直于鼻通道轴线97的表面为其次表面，次表面的宽度小于主表面的宽度，以减小空气阻力；弹性扩张臂3的外侧主表面35全部地贴合鼻通道内壁96，使其能够向鼻翼92施加来自弹性扩张臂3和弹性支撑辐条7的扩张力。
如图8所示，佩戴时，弹性扩张臂3被鼻通道内壁96压缩，远臂33和近臂32相互靠近，弯曲部31的回弹力促使远臂33和鼻通道接合元件4向鼻翼92施加扩张力，从而扩张鼻通道，同时，弹性扩张臂3和鼻通道接合元件4与鼻通道内壁96紧密贴合，其相互作用力将缓释装置1固定在鼻通道95内。由于弹性扩张臂3为开口结构，所以对不同形状和尺寸的鼻通道适应性较强，特别适用于因鼻中隔偏曲症导致的左右鼻通道尺寸不同的使用者。
如图6所示，当鼻通道接合元件4的宽度等于或小于弹性扩张臂3的宽度，且二者的同侧主表面平滑连接并融合为同一表面时，也即：内侧主表面34和内主表面41融合为一个表面、外侧主表面35和外主表面42融合为一个表面，此时弹性扩张臂3和鼻通道接合元件4融合为一体，弹性扩张臂3和鼻通道接合元件4都贴合鼻通道内壁96，二者的主表面其实是同一个表面，因此可视为融合。鼻通道接合元件4的功能完全由弹性扩张臂3替代，此时扩张机构不再包括鼻通道接合元件4，仅包括弹性扩张臂3和弹性支撑辐条7。
如图6所示，作为优化，所述弹性扩张臂3的近臂32和远臂33的末端向鼻通道95内侧弯曲，形成钩状物36，以避免其末端刺激鼻通道内壁。
如图2、3和8所示，扩张机构具有一个分叉的弹性支撑辐条7，其包括：第一分支73、第二分支74、第三分支75和第四分支76；其中，第一分支73连接于弹性扩张臂3的远臂33，第二分支74和第四分支76连接于近臂32，第三分支75连接于鼻通道接合元件4；佩戴时，弹性支撑辐条7将自身压缩后的回弹力施加于弹性扩张臂3和鼻通道接合元件4；弹性支撑辐条7的多个分支使其具有更强的回弹力，从而进一步提升了扩张效果，同时，其多个分支增加了对弹性扩张臂3和鼻通道接合元件4的支撑点，从而进一步提升了扩张的针对性和平衡性。
图6描述了第一个优选实施例设置有一个弹性支撑辐条7的情况，弹性支撑辐条7为弧形的带状结构，其两端连接于弹性扩展臂3的内侧主表面34的不同位置；带状弹性支撑辐条7能够提升扩张效果并加强扩张的针对性和平衡性，同时，其还具有结构简单、空气阻力小的特点；作为优化，可根据实际需要设置多条带状弹性支撑辐条7，以进一步提升扩张力度和平衡性。
如图2所示，所述两个释放机构对称设置，每个释放机构对应地设置在每个扩张机构内，每个释放机构包括：一个固定管5和一个释放元件6；
如图2所示，所述固定管5为圆管状结构，其固定于弹性支撑辐条7上，固定管5用于环绕和固定释放元件6；作为优化，固定管5还可设置于弹性扩张臂3的内侧主表面34上，或设置于鼻通道接合元件4的内主表面41上。
如图2和7所示，所述释放元件6为两端宽且中部窄的结构，其包括：中空的圆管状药桶61和连接并覆盖于药桶两端的桶盖62和桶底63；
桶盖62和桶底63的外径大于药桶61的外径，佩戴时，所述释放元件6固定在固定管5上，固定管5环绕于药桶61，并与其紧密咬合，桶盖62和桶底63位于固定管5两端的外侧，其外径大于固定管5的内径，使释放元件6无法从固定管5上脱离，此时释放元件6位于鼻通道95内；桶盖62上设有柱状凸起622，其外侧设有螺纹623，将柱状凸起622旋入药桶61的开口端，使螺纹623与药桶61开口端的螺口611紧密咬合，实现螺纹配合，从而将药桶61和桶盖62连接起来；桶底63与药桶61为一体式结构；所述药桶61用于容纳固态和液态化合物，桶盖62上设有一个第一孔621，让所述化合物通过第一孔621释放至鼻通道；药桶61的内容物64为多孔材料制成的吸纳块641和吸纳于其中的液态化合物，吸纳块641能够防止液态化合物从第一孔621流出，其多孔表面还能够提升化合物的释放速度。释放机构可以方便地更换药桶的内容物64，也可以更换具有不同开口数量和开口大小的桶盖62以调整释放速度，还可以将释放元件6整体替换为多孔材料来适应不同的释放需求。
实施例2.
图10、11、12和13为本发明的第二个优选实施例，该缓释装置1包括：一个连接机构、两个扩张机构和两个释放机构。
如图10和11所示，所述连接机构包括：一个U形结构的连接梁2，所述连接梁2半环绕于鼻中隔91的下端，该连接梁2包括：位于鼻中隔91下侧的中间部23和位于鼻中隔91两侧的两个连接臂24；连接梁2的两个连接臂24由鼻中隔91的两侧插入两个鼻通道95内，其分别一体式地连接于对称设置在两个鼻通道95内的两个环状的弹性扩张臂3；
所述连接梁2还为缓释装置1提供固定功能，其两个连接臂24的最小间距小于该处鼻中隔91的宽度，使其向鼻中隔91施加包夹力，从而让缓释装置1包夹并固定于鼻中隔91；连接梁2向鼻中隔91施加包夹力的部位为加宽部241，连接臂24朝向鼻中隔91的表面在加宽部241变得更宽，以增大加宽部241与鼻中隔91的贴合面积，从而减小加宽部241对鼻中隔91的压强，以提升舒适度。
作为优化，所述连接梁2的两个连接臂24可对称设置朝向佩戴者的鼻中隔91的凸起242；所述凸起242贴合鼻中隔91的两侧，并向鼻中隔91施加包夹力；所述凸起242可与所述加宽部241合并为同一部位。
作为优化，所述连接梁2的两个连接臂24的端部可设置插头243，所述插头243插入设置于弹性扩张臂3的插孔77中，所述插头243为两端宽且中部窄的结构，实现插接式固定
如图10和11所示，所述每个扩张机构包括：一个环状的弹性扩张臂3，其平行于鼻通道轴线97的一对表面是其主表面和最大表面，所述一对主表面为内侧主表面34和外侧主表面35，弹性扩张臂3垂直于鼻通道轴线97的表面为其次表面，次表面的宽度小于主表面的宽度，以减小呼吸阻力；佩戴时，环状的弹性扩张臂3插入鼻通道95并被鼻通道内壁96压缩，其回弹力促使其对鼻通道内壁96施加扩张力，同时，弹性扩张臂3与鼻通道内壁96紧密贴合，二者的相互作用力将缓释装置1固定在鼻通道95内。环状的弹性扩张臂3可以全方位的扩张鼻通道，并能够增大弹性扩张臂3与鼻通道内壁96的接触面积，以减小扩张机构对鼻通道内壁的压强，从而提升舒适性。
图12描述了第二个优选实施例设置有分叉的弹性支撑辐条7的情况，弹性支撑辐条7包括：第一分支73、第二分支74和第三分支75，所述三个分支均为可弹性压缩的弧形条状 结构，其末端均连接于弹性扩张臂3的上表面，并由此将弹性支撑辐条7受压后的回弹力施加于弹性扩张臂3，所述多个分支有利于进一步提升扩张的力度以及扩张的针对性和平衡性；另外，所述弹性支撑辐条7、固定管5和释放元件6均位于弹性扩张臂3的上方，使得释放元件6能够更深入鼻通道95，有利于其向呼吸道的较深部位释放化合物。
如图10和11所示，所述两个释放机构对称设置，每个释放机构对应地设置在每个扩张机构内，每个释放机构包括：一个固定管5和一个释放元件6；
如图10和11所示，所述固定管5为圆管状结构，其固定于环状的弹性扩张臂3的内侧主表面34，固定管5用于环绕和固定释放元件6；如图12所示，作为优化，固定管5设置于弹性支撑辐条7上。
如图10、11和13所示，所述释放元件6为两端宽且中部窄的结构，其包括：管状药桶61和连接并覆盖于药桶两端的桶盖62和桶底63；桶盖62和桶底63的外径均大于药桶61的外径，佩戴时，所述释放元件6固定在固定管5上，固定管5环绕于药桶61，并与其紧密咬合，桶盖62和桶底63位于固定管5的两端的外侧，其外径大于固定管5的内径，使释放元件6无法从固定管5上脱离，此时释放元件6位于鼻通道95内；桶盖62上设有柱状凸起622，其外侧设有多个半球状凸起624，将柱状凸起622插入药桶61的开口端，使半球状凸起624与药桶61开口端设置的多个卡孔612紧密咬合，从而将药桶61和桶盖62连接起来；桶底63与药桶61为一体式结构；所述药桶61的内容物64为可挥发的固态化合物642，桶盖62上设有五个第一孔621，桶底63上设有一个第二孔631，使药桶61的内腔形成贯穿的气流，让固态化合物642挥发并释放至鼻通道95。释放机构可以方便的替换药桶的内容物64，也可以更换具有不同开口数量的桶盖62以调整释放速度，还可以将释放元件6整体替换为多孔材料来适应不同的释放需求。
实施例3.
图14、15、16、17A和17B为本发明的第三个优选实施例，该缓释装置1包括：一个连接机构、两个扩张机构和两个释放机构。
如图14、15和16所示，所述连接机构包括：两个连接梁2，具体为纵向并列设置的第一连接梁21和第二连接梁22，第一连接梁21和第二连接梁22均半环绕于鼻中隔91的下端，第一连接梁21为C形结构，其由位于鼻中隔91下侧的第一中间部213和位于鼻中隔91两侧的两个第一连接臂214构成，所述两个第一连接臂214由鼻中隔91的两侧插入两个鼻通道95内，其分别一体式地连接于对称设置在两个鼻通道95内的扩张机构；第二连接梁22由位于鼻中隔91下侧的第二中间部223和位于鼻中隔91两侧的两个第二连接臂224构成，所述两个第二连接臂224由鼻中隔91的两侧插入两个鼻通道95内，其分别以插接方式可拆卸地连接于对称设置在两个鼻通道95内的扩张机构。
如图14、15和16所示，由于第一连接梁21与扩张机构为一体式结构，其材料不能提供充分的包夹力，因此连接机构设置了第二连接梁22来补充包夹力。第二连接梁22通过两个部位向鼻中隔91施加包夹力：一是设置于两个第二连接臂224的末端的插头243将包夹力通过第一弹性支撑辐条71传导至环状的弹性扩张臂3，再由弹性扩张臂3靠近鼻中隔91的外侧主表面35施加于鼻中隔91；二是设置于两个第二连接臂224中部朝向鼻中隔91的两个凸起242，所述两个凸起242与鼻中隔91的两侧贴合，并向鼻中隔91施加包夹力；作为优化，第一连接梁21的两个第一连接臂214可设置相同功能的凸起242。
如图16所示，所述第二连接梁22的两个第二连接臂224的端部设有插头243，所述插头243插入设置于第一弹性支撑辐条71根部的插孔77中，实现插接式固定，所述插头243为两端宽且中部窄的结构，其包括：帽2431、柱2432和柄2433；其中，帽2431和柄2433的最大宽度均大于柱2432的最大宽度；安装后，插孔77环绕于柱2432并与之紧密咬合，帽2431和柄2433分别位于插孔77两端的外侧，二者的最大宽度均大于插孔77的内腔的最 大宽度，使插头243无法脱出；优选的，柱2432和插孔77的内腔为四棱柱结构，二者紧密咬合，以避免扩张机构绕插头243发生旋转；作为优化，第一连接梁21的两个第一连接臂214的端部可设置相同的插头243，并以插接的方式连接于弹性扩张臂3或弹性支撑辐条7。
作为优化，所述第一连接梁21的两个第一连接臂214可对称地设置加宽部241，且第一连接臂214朝向鼻中隔91一侧的表面的宽度在加宽部241增大，所述两个加宽部241贴合鼻中隔91的两侧，并向鼻中隔91加包夹力；作为优化，所述第二连接梁22的两个第二连接臂224可对称地设置加宽部241，且第二连接臂224朝向鼻中隔91一侧的表面的宽度在加宽部241增大，所述两个加宽部241贴合鼻中隔91的两侧，并向鼻中隔91加包夹力；所述加宽部241可与凸起242合并为同一部位。
如图14所示，所述每个扩张机构包括：一个弹性扩张臂3和两个弹性支撑辐条7。
如图14和15所示，所述弹性扩张臂3为环状结构，其与连接臂24的端部连接，弹性扩张臂3平行于鼻通道轴线97的一对表面是其主表面和最大表面，所述一对主表面为内侧主表面34和外侧主表面35，弹性扩张臂3垂直于鼻通道轴线97的表面为其次表面，次表面的宽度小于主表面的宽度，以减小呼吸阻力；外侧主表面35贴合鼻通道内壁96，使其能够向鼻通道95施加来自弹性扩张臂3和弹性支撑辐条7的扩张力，也能够向鼻中隔91施加来自第二连接梁22的包夹力。佩戴时，弹性扩张臂3被鼻通道内壁96压缩，其回弹力促使其对鼻通道95施加全方位的扩张力，同时，弹性扩张臂3与鼻通道内壁96紧密贴合，二者的相互作用力将缓释装置1固定在鼻通道95内。环状的弹性扩张臂3可以全方位的扩张鼻通道，并能够增大二者的接触面积以减小扩张机构对鼻通道内壁的压强，从而提升舒适性。
如图14和15所示，所述两个弹性支撑辐条7为第一弹性支撑辐条71和第二弹性支撑辐条72，二者均为带状结构，并间隔放置于弹性扩张臂3内，即第一弹性支撑辐条71和第二弹性支撑辐条72的一端连接于弹性扩张臂3靠近鼻中隔91的内侧主表面34、另一端连接于弹性扩张臂3靠近鼻翼92的内侧主表面34，从而保证其回弹力有针对性的施加于鼻翼92。
如图14和15所示，所述两个释放机构对称设置，每个释放机构对应地设置在每个扩张机构内，每个释放机构包括：一个固定管5和一个释放元件6；
如图14所示，所述固定管5的内腔为四棱柱结构，其固定于第二弹性支撑辐条72上，固定管5环绕并固定释放元件6；作为优化，固定管5还可设置在支撑辐条71上，或设置于弹性扩张臂3的内侧主表面34上。
如图14和17A所示，所述释放元件6为两端宽且中部窄的结构，其两端和中部均为四棱柱状结构，佩戴时，所述释放元件6固定在固定管5上，固定管5环绕于释放元件6的中部，并与其紧密咬合，释放元件6的中部和固定管内腔的四棱柱结构可以避免释放元件6发生旋转，释放元件6的两端位于固定管5两端的外侧，其最大宽度大于固定管5内腔的最大宽度，使释放元件6无法从固定管5上脱离；佩戴时，所述的释放元件6位于鼻通道95内；
释放元件6为多孔材料制成，能够吸纳和保存液态化合物，其较宽的两端和多孔的表面有利于化合物的挥发，还有利于鼻通道的吸入气流带走微小的化合物液滴，特别的，所述多孔材料能够以微小液滴的形式释放非挥发性液态化合物。
如图17B所示，作为优化，所述多孔材料制成的释放元件6的两端设有隆起物65，以进一步扩大其表面积，提升释放化合物的速度。
最后所应说明的是，以上实施例仅用以说明本发明的技术方案而非限制。尽管参照实施例对本发明进行了详细说明，本领域的普通技术人员应当理解，对本发明的技术方案进行修 改或者等同替换，都不脱离本发明技术方案的精神和范围，其均应涵盖在本发明的权利要求范围当中。

Claims (20)

  1. 一种在鼻通道内缓慢释放化合物的缓释装置，其特征在于，所述缓释装置(1)包括：一个连接机构、两个扩张机构和两个释放机构；所述连接机构的两端分别一体式或可拆卸式地连接对称设置在两侧鼻通道(95)内的两个扩张机构；所述两个释放机构对称设置，每个释放机构对应地设置在每个扩张机构内；
    所述连接机构包括至少一个连接梁(2)，所述连接梁(2)半环绕于鼻中隔(91)的下端，其包括：位于鼻中隔(91)下侧的中间部(23)和对称设置于鼻中隔(91)两侧的两个连接臂(24)；中间部(23)位于两个连接臂(24)之间；两个连接臂(24)分别连接对称设置在两个鼻通道(95)内的两个扩张机构；
    所述释放机构包括：至少一个固定管(5)和至少一个释放元件(6)；
    所述固定管(5)为管状结构，其设置在扩张机构上；所述释放元件(6)为两端宽且中部窄的结构，佩戴时，释放元件(6)固定在固定管(5)内，固定管(5)环绕于释放元件(6)较细的中部，并与其紧密咬合，释放元件(6)的两端位于固定管(5)两端的外侧，释放元件(6)两端的最大宽度大于固定管(5)内腔的最大宽度；所述释放元件(6)能够容纳一定量的化合物，并允许所容纳的化合物在鼻通道(95)内缓慢释放，佩戴时，至少部分释放元件(6)位于鼻通道(95)内。
  2. 根据权利要求1所述的在鼻通道内缓慢释放化合物的缓释装置，其特征在于，所述扩张机构包括：一个弹性扩张臂(3)；该弹性扩张臂(3)为环状闭合结构，其与一个连接臂(24)的端部连接；固定管(5)设置在弹性扩张臂(3)的内侧主表面(34)，释放元件(6)套设在固定管(5)内。
  3. 根据权利要求2所述的在鼻通道内缓慢释放化合物的缓释装置，其特征在于，所述连接梁(2)的两个连接臂(24)对称地设置有加宽部(241)，且连接臂(24)朝向鼻中隔(91)一侧的表面的宽度在加宽部(241)增大；所述两个加宽部(241)贴合鼻中隔(91)的两侧，并向鼻中隔(91)加包夹力。
  4. 根据权利要求1所述的在鼻通道内缓慢释放化合物的缓释装置，其特征在于，所述扩张机构包括：一个弹性扩张臂(3)和至少一个弹性支撑辐条(7)；
    所述弹性扩张臂(3)为环状闭合结构，其与一个连接臂(24)的端部连接；弹性支撑辐条(7)分叉并包括多个分支，每个分支的一端连接于弹性支撑辐条(7)的主干部位，其另一端固定在弹性扩张臂(3)上；固定管(5)设置于弹性支撑辐条(7)上，释放元件(6)套设在固定管(5)内。
  5. 根据权利要求4所述的在鼻通道内缓慢释放化合物的缓释装置，其特征在于，所述弹性支撑辐条(7)、固定管(5)和释放元件(6)位于弹性扩张臂(3)的上方，形成倒置的碗状结构。
  6. 根据权利要求1所述的在鼻通道内缓慢释放化合物的缓释装置，其特征在于，所述扩张机构包括：一个弹性扩张臂(3)和至少一个弹性支撑辐条(7)；
    所述弹性扩张臂(3)为环状闭合结构，其与一个连接臂(24)的端部连接；弹性支撑辐条(7)为带状结构，其两端连接于弹性扩张臂(3)。
  7. 根据权利要求6所述的在鼻通道内缓慢释放化合物的缓释装置，其特征在于，所述连接机构包括纵向并列设置的第一连接梁(21)和第二连接梁(22)；第一连接梁(21)和第二连接梁(22)均半环绕于鼻中隔(91)的下端。
  8. 根据权利要求7所述的在鼻通道内缓慢释放化合物的缓释装置，其特征在于，所述第二连接梁(22)的两个第二连接臂(224)对称设置有朝向佩戴者的鼻中隔(91)的凸起(242)；所述凸起(242)贴合鼻中隔(91)的两侧，并向鼻中隔(91)施加包夹力。
  9. 根据权利要求7所述的在鼻通道内缓慢释放化合物的缓释装置，其特征在于，所述第二连接梁(22)的两个第二连接臂(224)的端部设有插头(243)，所述插头(243)插入设置于第一弹性支撑辐条(71)根部的插孔(77)中，所述插头(243)为两端宽且中部窄的结构，实现插接式固定。
  10. 根据权利要求1所述的在鼻通道内缓慢释放化合物的缓释装置，其特征在于，所述扩张机构包括：一个弹性扩张臂(3)、一个鼻通道接合元件(4)和至少一个弹性支撑辐条(7)；
    弹性扩张臂(3)为可弹性压缩的开口带状结构，其与一个连接臂(24)的端部连接，弹性扩张臂(3)的外侧主表面(35)可部分地或全部地贴合鼻通道内壁(96)，使其既能够向鼻翼(92)施加来自弹性扩张臂(3)和弹性支撑辐条(7)的扩张力，也能够向鼻中隔(91)施加来自连接梁(2)的包夹力；
    鼻通道接合元件(4)为片状结构，其与弹性扩张臂(3)连接,并使扩张机构保持开口结构；佩戴时，鼻通道接合元件(4)位于鼻翼(92)的内侧，其外主表面(42)与鼻翼(92)的内壁贴合，并向鼻翼(92)施加来自弹性扩张臂(3)和弹性支撑辐条(7)的扩张力；
    弹性支撑辐条(7)为可弹性压缩的带状或条状结构，其两端连接于弹性扩张臂(3)或鼻通道接合元件(4)。
  11. 根据权利要求10所述的在鼻通道内缓慢释放化合物的缓释装置，其特征在于，所述弹性扩张臂(3)与鼻通道接合元件(4)融合为一体。
  12. 根据权利要求10所述的在鼻通道内缓慢释放化合物的缓释装置，其特征在于，所述弹性扩张臂(3)垂直于鼻通道轴线(97)的横截面为V形结构或C形结构，其包括：弯曲部(31)、近臂(32)和远臂(33)；
    所述弯曲部(31)的一端连接近臂(32)，其另一端连接远臂(33)，佩戴时，近臂(32)靠近鼻中隔(91)，远臂(33)靠近鼻翼(92)，弯曲部(31)靠近鼻梁(93)或鼻底(99)。
  13. 根据权利要求10所述的在鼻通道内缓慢释放化合物的缓释装置，其特征在于，所述弹性扩张臂(3)与鼻通道内壁(96)贴合的部位，其端部向鼻通道(95)内侧弯曲；所述鼻通道接合元件(4)的端部向鼻通道(95)内侧弯曲。
  14. 根据权利要求10所述的在鼻通道内缓慢释放化合物的缓释装置，其特征在于，所述弹性支撑辐条(7)分叉并具有多个分支，所述每个分支的一端连接于弹性支撑辐条(7)的主干部位，其另一端固定在弹性扩张臂(3)或鼻通道接合元件(4)上。
  15. 根据权利要求1所述的在鼻通道内缓慢释放化合物的缓释装置，其特征在于，所述连接梁(2)向鼻中隔(91)施加包夹力，该包夹力由连接梁(2)的两个连接臂(24)直接施加于鼻中隔(91)的下端，或该包夹力由连接梁(2)的两个连接臂(24)传导至对应的扩张机构后，由对应的扩张机构施加于鼻中隔(91)的下端。
  16. 根据权利要求1所述的在鼻通道内缓慢释放化合物的缓释装置，其特征在于，连接梁(2)的中间部(23)的平均横截面积较连接臂(24)的平均横截面积更大。
  17. 根据权利要求1所述的在鼻通道内缓慢释放化合物的缓释装置，其特征在于，所述释放元件(6)包括：药桶(61)，以及连接并覆盖于药桶(61)两端的桶盖(62)和桶底(63)；桶盖(62)的最大直径大于药桶(61)的最大直径；桶底(63)的最大直径大于药桶(61)的最大直径；
    所述药桶(61)为中空的管状结构，其内部容纳有化合物，所述桶盖(62)和桶底(63)上设置有至少一个开口，使化合物通过所述开口向鼻通道(95)排出。
  18. 根据权利要求17所述的在鼻通道内缓慢释放化合物的缓释装置，其特征在于，所述药桶(61)内设置有多孔材料制成的吸纳块(641)。
  19. 根据权利要求1所述的在鼻通道内缓慢释放化合物的缓释装置，其特征在于，所 述释放元件(6)采用多孔材料制成。
  20. 根据权利要求19所述的在鼻通道内缓慢释放化合物的缓释装置，其特征在于，所述释放元件(6)的外表面设置有隆起物(65)。
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