WO2022223000A1 - 保湿组合物、皮肤修护特护霜、粉底组合物及其制备方法 - Google Patents

保湿组合物、皮肤修护特护霜、粉底组合物及其制备方法 Download PDF

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WO2022223000A1
WO2022223000A1 PCT/CN2022/088197 CN2022088197W WO2022223000A1 WO 2022223000 A1 WO2022223000 A1 WO 2022223000A1 CN 2022088197 W CN2022088197 W CN 2022088197W WO 2022223000 A1 WO2022223000 A1 WO 2022223000A1
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Prior art keywords
content
moisturizing
skin
cream
present disclosure
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PCT/CN2022/088197
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English (en)
French (fr)
Inventor
钱进
向琼彪
邓慧
李华真
李传茂
林盛杰
张伟杰
曾伟丹
张楚标
Original Assignee
广州市科能化妆品科研有限公司
广东丹姿集团有限公司
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Priority claimed from CN202110441035.9A external-priority patent/CN113304067A/zh
Priority claimed from CN202110745742.7A external-priority patent/CN113398003A/zh
Priority claimed from CN202111164671.8A external-priority patent/CN113768800A/zh
Application filed by 广州市科能化妆品科研有限公司, 广东丹姿集团有限公司 filed Critical 广州市科能化妆品科研有限公司
Publication of WO2022223000A1 publication Critical patent/WO2022223000A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present disclosure relates to a moisturizing composition, a special skin repair cream, a foundation composition and a preparation method thereof, belonging to the field of cosmetics.
  • the stratum corneum is mainly composed of keratinocytes and their extracellular substance.
  • the endoplasm of keratinocytes is mainly rich in protein and a variety of natural moisturizing factors, and its extracellular plasm is composed of lipids such as cholesterol, ceramides, and free fatty acids.
  • lipids such as cholesterol, ceramides, and free fatty acids.
  • the existence of these substances can not only effectively prevent the loss of water in the body, but also prevent the erosion of harmful substances from the outside world. If the water content of the stratum corneum is low, the skin will appear dry, cracked and rough. Therefore, a variety of moisturizing agents are often used in cosmetics to maintain the effect of replenishing the skin's moisture.
  • humectants can be divided into four categories, small molecule humectants, macromolecular humectants, occlusive oils and new high-efficiency humectants.
  • small molecule moisturizers include glycerin, butylene glycol, propylene glycol, etc.
  • Common polymer moisturizers include sodium hyaluronate, polysaccharides, etc.
  • glycerol has a small molecular weight and can form a dense protective film on the skin surface.
  • moisturizing agents and oils made of glycerin on moisturizing performance found that simply using glycerin has obvious moisturizing effect, and with the increase of glycerin content, Epidermal moisture content increased.
  • the amount of glycerin is too large, it will produce a sticky feeling.
  • Hyaluronic acid is a component in the dermis of the human body. It has the ability to retain moisture. The amount is up to 100 times its own weight.
  • the use of skin care products containing hyaluronic acid HA can improve dry and wrinkled skin. It restores some smoothness and elasticity, therefore, hyaluronic acid is the ideal product to improve dry and aging skin.
  • the aqueous solution of 0.05%-0.2% hyaluronic acid has no obvious moisturizing effect.
  • hyaluronic acid has a large molecular structure and is prone to agglomeration after being applied to the skin; in addition, hyaluronic acid has many hydroxyl groups, and the adhesion on the skin surface mainly depends on the hydrogen bonding force of the hydroxyl group, and when the hydroxyl group cannot When water is absorbed from the outside, the water content of the epidermis cannot be increased.
  • the technical problem to be solved by the present disclosure is to provide a moisturizing composition, which can increase the water content of the skin epidermis, and can achieve deep moisturizing in essence, when it is applied in cosmetics or skin care products, Can have excellent moisturizing effect.
  • the present disclosure first provides a special skin repair cream, which can repair skin barrier and control skin inflammation. And excellent moisturizing and moisturizing.
  • the present disclosure also provides a foundation composition with skin repairing effect.
  • the foundation composition of the present disclosure has strong skin repairing effect and still has excellent concealing ability.
  • the present disclosure provides a moisturizing composition, calculated based on the total mass of the moisturizing composition as 100%, comprising the following components:
  • Polyol 60% to 99.8%, preferably 70% to 94%;
  • Hyaluronic acid or its salt 0.1% to 10%, preferably 0.3% to 5%;
  • Ceramide 0.1% to 30%, preferably 1.5% to 25%.
  • the mass ratio of the polyol, the hyaluronic acid or its salt, and the ceryl ester is: 100:(0.5-2.5):(1.5-25).
  • the moisturizing composition according to the present disclosure wherein the polyhydric alcohol comprises: glycerin, 1,4-butanediol, pentanediol, 1,2-propanediol, 1,3-propanediol, dipropylene glycol, methyl propylene glycol one or a combination of two or more.
  • the moisturizing composition of the present disclosure wherein the moisturizing composition further comprises D-panthenol, preferably, based on the total mass of the moisturizing composition as 100%, the added amount of the D-panthenol It is: 0.5% to 30%, preferably 4 to 25%.
  • the mass ratio of the polyol to the D-panthenol is 100:(4-25).
  • the present disclosure also provides a preparation method of the moisturizing composition according to the present disclosure, which includes the step of mixing each component of the moisturizing composition.
  • the present disclosure also provides a special skin repair cream, which, based on the total mass of the skin repair cream as 100%, includes the following components:
  • Anti-inflammatory repair component 0.13%-13%;
  • the moisturizing components include polyols, hyaluronic acid or a salt thereof, and ceramides.
  • the added amount of the polyol is 1%-10% ; the added amount of the ceryl ester is 0.01%-1%; the added amount of the hyaluronic acid or its salt is 0.01%-0.3%.
  • the anti-inflammatory repairing components include one or a combination of two or more selected from the group consisting of madecassoside, polypeptide, patchouli leaf extract and salvia miltiorrhiza extract. ;
  • the content of the madecassoside is 0.01%-1%; the content of the polypeptide is 0.01%-5%; The content of the Agaricus leaves extract is 0.01%-2%; the content of the Salvia miltiorrhiza extract is 0.1%-5%.
  • the polypeptide comprises oligopeptide-1 and/or palmitoyl tetrapeptide-7.
  • the skin repairing special cream according to the present disclosure wherein the barrier repairing component includes ceramides and/or phytosterol canola oil glycerides;
  • the content of the ceramide is 0.01%-1%; the content of the phytosterol canola oil glycerides is 0.1% -5%.
  • the special skin repair cream according to the present disclosure, wherein the special skin repair cream further comprises one or a combination of two or more of emulsifiers, emollient oils, thickeners and preservatives;
  • the content of the emulsifier is 0.1-1%; the content of the emollient oil is 1%-10%, the content of the thickener is 0.3%-1%, and the content of the preservative is 0.1%-1%.
  • the present disclosure also provides a preparation method of the skin repairing special cream according to the present disclosure, which includes the step of mixing each component of the skin repairing special cream.
  • the present disclosure further provides a foundation composition, calculated on the basis of the total mass of the foundation composition as 100%, comprising the following composition:
  • Concealer component 28.4%-70.8%, preferably 30%-65%;
  • Repair component 0.91%-3.6%, preferably 1%-3%;
  • Moisturizing component 3%-10%, preferably 4%-9%;
  • Soothing component 0.3%-6%, preferably 1-3%; wherein,
  • the moisturizing components include polyols, hyaluronic acid or a salt thereof, and ceramides.
  • the concealer component comprises titanium dioxide
  • the content of the titanium dioxide is 12-24% based on 100% of the total mass of the foundation composition; preferably, The average particle size of the titanium dioxide is 50nm-200nm.
  • the concealer component further comprises one or a combination of two or more of pigments, dispersants, emollient oils, elastomers, silicas and film-forming agents; preferably, Based on 100% of the total mass of the foundation composition, the content of the pigment is 0.1%-1.5%, the content of the dispersant is 0.3-1.5%, and the content of the emollient oil is 10-28.8% , the content of the elastomer is 2%-5%, the content of the film-forming agent is 2%-5%, and the content of the silica is 2-5%.
  • the repairing component comprises one or a combination of two or more of essential oils, ceramides, and phytosterol canola glycerides; preferably, the foundation is
  • the total mass of the composition is 100%, the content of the essential oil is 0.4%-1.4%, the content of the ceramide is 0.01%-0.5%, and the content of the phytosterol canola oil glyceride is 0.5-1.4% 1.7%.
  • the content of the polyol is 2.88%-8.8%, and the content of the hyaluronic acid or its salt is 0.02%-0.2%, and the content of the ceryl ester is 0.1%-1%.
  • the soothing component comprises one or a combination of two or more selected from Cactus spinosa extract, Scutellaria baicalensis extract, Madecassoside, and Patchouli leaf extract .
  • the present disclosure further provides a preparation method of a foundation composition according to the present disclosure, which includes the step of mixing each component of the foundation composition.
  • the moisturizing composition of the present disclosure can increase the water content of the skin epidermis, can achieve deep moisturizing in essence, and can have an excellent moisturizing effect when applied in cosmetics or skin care products.
  • the skin repairing special cream of the present disclosure is not only excellent in repairing the skin barrier, controlling skin inflammation, and moisturizing, but also has a light skin feel.
  • the foundation composition of the present disclosure has strong skin repairing effect, excellent moisturizing effect, and still has excellent concealing ability.
  • references to “some specific/preferred embodiments”, “other specific/preferred embodiments”, “embodiments”, etc. refer to the specific elements described in relation to the embodiment (eg, features, structures, properties, and/or characteristics) are included in at least one embodiment described herein, and may or may not be present in other embodiments. Additionally, it should be understood that the described elements may be combined in any suitable manner in the various embodiments.
  • numerical range represented by "numerical value A to numerical value B” means a range including numerical values A and B at the endpoints.
  • the "water” includes deionized water, distilled water, ion-exchanged water, double-distilled water, high-purity water, purified water and any other feasible water that can be used in the cosmetic field.
  • a first aspect of the present disclosure provides a moisturizing composition, based on 100% of the total mass of the moisturizing composition, comprising the following components:
  • Polyol 60% to 99.8%, preferably 70% to 94%;
  • Hyaluronic acid or its salt 0.1% to 10%, preferably 0.3% to 5%;
  • Ceramide 0.1% to 30%, preferably 1.5% to 25%.
  • the moisturizing composition of the present disclosure can effectively increase the water content of the skin epidermis, can achieve deep moisturizing in essence, and can have an excellent moisturizing effect when applied in cosmetics or skin care products.
  • the polyols of the present disclosure are lower molecular weight polyols.
  • the polyol can not only form a dense protective film on the skin surface to reduce the loss of water, but also promote the moisturizing composition of the present disclosure to absorb water from the environment, replenish it into the skin, and increase the water content on the skin surface.
  • the polyols include: one or both of glycerol, 1,4-butanediol, pentanediol, 1,2-propanediol, 1,3-propanediol, dipropylene glycol, and methyl propylene glycol more than one combination.
  • the present disclosure uses glycerin as the polyol. When glycerin is used, the effect of the moisturizing composition of the present disclosure can be maximized, and the water content of the skin surface can be effectively increased.
  • the polyol is added in an amount of 60% to 99.8%, preferably 70% to 94%, such as 62%, 65%, 68%, 71%, 73%, 75%, 78%, 80%, 82%, 85%, 88%, 91%, 95%, 97%, etc.
  • 70% to 94% such as 62%, 65%, 68%, 71%, 73%, 75%, 78%, 80%, 82%, 85%, 88%, 91%, 95%, 97%, etc.
  • the content of polyol is less than 60%, it cannot increase the water content of the skin surface.
  • the content of polyol is higher than 99.8%, other components are too low, although it can increase the water content of the skin surface. effect, but will affect the skin feel and cost of the product.
  • Hyaluronic acid also known as hyaluronic acid
  • Hyaluronic acid is an acidic mucopolysaccharide. It is an important basic substance for skin suppleness, and it is also a component of the human body. It has a special water-retaining effect, and its weight is up to 100 times its own weight. It is the best moisturizing substance found in nature. It is an ideal natural moisturizing factor. It can improve skin nutrition metabolism, make skin soft, smooth, wrinkle-free, increase elasticity, prevent aging, and it is a good transdermal absorption enhancer while moisturizing. Used in conjunction with other nutrients, it can play a more ideal effect of promoting nutrient absorption.
  • the weight-average molecular weight of the hyaluronic acid or its salt may be below 1.8 million Daltons, preferably 1 million-1.8 million Daltons.
  • the commonly used hyaluronate can be its sodium salt form, namely sodium hyaluronate (SODIUM HYALURONATE, SH for short).
  • Sodium hyaluronate is a substance extracted from cockscomb, which can also be obtained by fermentation of lactobacillus. It is white or off-white granules or powder, odorless, when dry, the nitrogen content is 2.8%-4.0%, glucuronic acid The content is 37.0%-51.0%.
  • hyaluronic acid or its salts due to the large molecular structure of hyaluronic acid or its salts, it is prone to agglomeration after being applied to the skin; in addition, hyaluronic acid or its salts have many hydroxyl groups, and the adhesion on the skin surface mainly depends on the hydrogen bonding force of the hydroxyl groups. However, when the hydroxyl group cannot absorb water to the outside world, the water content of the epidermis cannot be increased.
  • the inventors of the present disclosure have found that in the presence of polyols and ceryl esters, the function of hyaluronic acid or its salts can be further promoted, and water can penetrate deep into the skin epidermis, thereby effectively increasing the water content of the skin epidermis, essentially achieving Deep hydration.
  • the amount of hyaluronic acid or its salt added is 0.1% to 10%, preferably 0.3% to 5%, such as 0.2%, 0.5%, 0.8%, 1.2%, 1.5% %, 1.8%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, etc.
  • the content of hyaluronic acid or its salt is less than 0.1%, the water content of the skin epidermis cannot be increased; when the added amount of hyaluronic acid or its salt is more than 10%, it will lead to excessive thickness, which is not conducive to skin absorption.
  • ceryl lipids are also called glycolipids, phytosphingosines.
  • the ceryl lipid of the present disclosure is to screen high-yielding strains from Candida, by adjusting the growth and fermentation conditions of the yeast and giving certain nutrients, so that during the growth and metabolism of the bacteria, the nutrients of olive oil are used to convert them into nerve cells.
  • Acyl lipids can easily penetrate into the intercellular space of the stratum corneum of the skin, maintain skin moisture, and play a role in moisturizing, emollient and skin barrier repair.
  • the ceryl lipids of the present disclosure are formed by linking fatty acids, mannose and erythrose.
  • the unique structure makes it easy to penetrate into the keratinocytes and fuse with the original outer cytoplasm to form a liquid crystal layer. Moisturizes and maintains skin moisture.
  • Ceramide itself has both lipophilic and hydrophilic groups, and is an amphiphilic molecule. If it can be used in combination with hyaluronic acid or its salt, it will help hyaluronic acid or its salt to spread on the skin surface. Moisturizing effect.
  • the inventors of the present disclosure found that in the presence of ceryl ester, the moisturizing function of polyol and hyaluronic acid or its salt can be further promoted, and the water content of skin epidermis can be effectively increased. It can promote the penetration of moisturizing agents into the keratinocytes, and achieve moisturizing effect by locking the moisturizing agent.
  • the ceryl ester of the present disclosure is added in an amount of 0.1% to 30%, preferably 1.5% to 25%, such as 0.2%, 0.5%, 0.8%, 1%, 3%, 5% %, 7%, 9%, 10%, 12%, 15%, 18%, 20%, 22%, 24%, 26%, 28%, etc.
  • the addition amount of the ceryl ester when the addition amount of the ceryl ester is less than 0.1%, the water content of the skin epidermis cannot be improved; when the addition amount of the ceryl ester is higher than 30%, it cannot bring better effects, It also leads to high costs.
  • the mass ratio of the polyol, hyaluronic acid or its salt, and ceryl ester is 100:(0.5-2.5):(1.5-25), for example: 100:(0.8-2.2 ):(3-22), 100:(1-2):(5-20), 100:(1.2-1.8):(8-18), 100:(1.4-1.6):(10-16), etc.
  • the mass ratio of the polyol, hyaluronic acid or its salt and ceryl ester is 100:(0.5-2.5):(1.5-25)
  • the moisturizing composition may also include D-panthenol.
  • D-panthenol (99%) is the precursor of vitamin B5, so it is also called provitamin B5. It contains no less than 99% of D-panthenol. It is a colorless to slightly yellow transparent and viscous liquid .
  • the inventors of the present disclosure have found that when D-panthenol is used, the efficacy of the present application in increasing the water content of the skin epidermis can be further improved.
  • the D-panthenol is added in an amount of 0.5% to 30%, preferably 4% to 25%, based on 100% of the total mass of the moisturizing composition; for example, 1% , 3%, 5%, 7%, 9%, 10%, 12%, 15%, 18%, 20%, 22%, 24%, 26%, 28%, etc.
  • the present disclosure can add D-panthenol to further improve the moisturizing effect of the moisturizing composition, when the addition amount of D-panthenol is 0.5% to 30%, the moisturizing effect of the high moisturizing composition can be exerted most effectively.
  • the mass ratio of the polyol to the D-panthenol may be 100:(4-25), for example: 100:(5-24), 100:(8-22), 100:(10- 20), 100: (12-18), 100: (14-16), etc.
  • the mass ratio of polyol and D-panthenol is 100:(4-25), more excellent moisturizing effect can be obtained.
  • the first aspect of the present disclosure also provides a preparation method of a moisturizing composition, which includes the step of mixing each component of the moisturizing composition; specifically, the preparation method of the moisturizing composition includes: at room temperature , weigh the moisturizing composition in proportion and mix.
  • the first aspect of the present disclosure further provides a skin care product comprising the moisturizing composition according to the present disclosure, preferably, the skin care product includes a lotion, cream, lotion, gel or essence. Specifically, based on the total mass of the skin care product as 100%, the addition amount of the moisturizing composition is 0.1-10%, preferably 0.5-8%, more preferably 1-5%.
  • a second aspect of the present disclosure provides a moisturizing cream
  • the cream contains the moisturizing composition described in the first aspect of the present application
  • the moisturizing cream containing the moisturizing composition of the present disclosure can increase the water content of skin epidermis, and has excellent moisturizing effect.
  • the added amount of the moisturizing composition is 0.1-10%, preferably 0.5-8%, more preferably 1-5%.
  • the moisturizing cream may include one or a combination of two or more of moisturizers, thickeners, oils, emulsifiers, and preservatives.
  • the formula composition of the moisturizing cream of the present disclosure is mild, and the efficacy of the moisturizing composition of the present disclosure can be fully exerted. in particular:
  • the added amount of the moisturizing agent is 0.01-10%.
  • the added amount of the moisturizing agent may be 1-8%, may be 2-7%, may be 3-6%, may be 4-5% and so on.
  • the humectant includes one or a combination of two or more of butylene glycol, dipropylene glycol, propylene glycol, glycerol polyacrylate, and trehalose.
  • the added amount of the thickener is 0.02-3%.
  • the moisturizing creams of the present disclosure can be made to have a suitable consistency by adding a thickening agent.
  • the added amount of the thickener of the present disclosure may be 0.05-2.5%, 0.1-2%, 0.2-1%, and the like.
  • the thickeners include carbomer, xanthan gum, dimethicone/vinyl dimethicone crosspolymer, behenyl alcohol, polyacrylamide, propylene One or a combination of two or more of ammonium acyl dimethyl taurate/VP copolymer (AVC) and hydroxyethyl acrylate/sodium acryloyl dimethyl taurate copolymer.
  • AVC ammonium acyl dimethyl taurate/VP copolymer
  • hydroxyethyl acrylate/sodium acryloyl dimethyl taurate copolymer hydroxyethyl acrylate/sodium acryloyl dimethyl taurate copolymer.
  • the added amount of the oil is 5-25%, for example, the added amount of the oil can be 8%, 10%, 12%, 15%, 18%, 20% %, 12%, 25%, etc.
  • oils By adding oils to your moisturizer, you can reduce the evaporation of moisture from the skin's surface, preventing dry and cracked skin.
  • a hydrophobic film can be formed on the skin surface, preventing the intrusion of external harmful substances.
  • the oil content is less than 5%, the evaporation of moisture on the skin surface cannot be reduced, and the intrusion of harmful substances cannot be effectively prevented; when the oil content is greater than 25%, the moisturizing cream will be too greasy and the feeling of use will be reduced.
  • oils and fats include isononyl isononanoate, beeswax, isopropyl myristate, dimethicone, cyclopentamethicone, shea butter, oleyl alcohol Erucate, Hydrogenated Polyisobutylene, Shea Butter, Ethylhexyl Palmitate, Hydrogenated Polydecene, Cyclohexoxane, C20-24 Alkyl Dimethicone, C13-14 Isoparaffin , C12-15 alcohol benzoate, hydrogenated soybean oil, phytosterols, oil and olive oil unsaponifiable one or a combination of two or more.
  • the added amount of the emulsifier is 0.05-5%, for example: it can be 0.1-5%, it can be 0.5-3%, it can be 1 -2% etc.
  • the dosage of the emulsifier in the present application is less than 0.05%, the emulsification is insufficient and the system is unstable; when the dosage of the emulsifier is greater than 5%, the stability of the product will also be affected to a certain extent.
  • the emulsifiers include cetearyl alcohol, cetearyl glucoside, sorbitan sesquioleate, isosteareth-20, PEG-10 canola sterol, lauryl alcohol Polyether-7, Polyglycerol-3 Methyl Glucose Distearate, PEG/PPG-10/1 Dimethicone, Polyglycerol-3 Diisostearate, Glyceryl Stearate , one or more combinations of steareth-20, ceteth-20, sorbitan stearate and polysorbate-60.
  • preservatives are also included in the moisturizing creams of the present disclosure. Based on the total mass of the moisturizing cream as 100%, the added amount of the preservative is 0.5-1.5%.
  • the preservatives may include one or a combination of two or more selected from Xinxan ketone, hexylene glycol, phenoxyethanol, methylparaben, propylparaben, benzoic acid and salts thereof.
  • the present disclosure also provides a preparation method of a moisturizing cream, including the step of mixing each component of the cosmetic.
  • the preparation method of described moisturizing cream comprises the following steps:
  • phase C Premix the preservative and heat it to 60-75°C until the powder is completely dissolved. For use, it is recorded as phase C;
  • phase B At 80°C-85°C, add phase B into phase A and make it homogeneous
  • a third aspect of the present disclosure provides a skin repairing special cream, based on 100% of the total mass of the skin repairing special cream, which includes the following components:
  • Anti-inflammatory repair component 0.13%-13%;
  • the moisturizing components include polyols, hyaluronic acid or a salt thereof, and ceramides.
  • the skin repairing cream of the present disclosure is not only excellent in repairing the skin barrier, controlling skin inflammation, and moisturizing, but also has a light skin feel.
  • the moisturizing component of the third aspect of the present disclosure includes a polyol, a hyaluronic acid or a salt thereof, and a ceramide.
  • the moisturizing component can effectively increase the moisture content of the skin epidermis, and can achieve deep moisturizing in essence, and when it is applied in the skin repairing cream of the present disclosure, it can have an excellent moisturizing effect.
  • the polyol, hyaluronic acid or its salt, and ceryl lipid in the moisturizing component of the third aspect of the present disclosure are substantially the same as the polyol, hyaluronic acid or its salt, and ceryl lipid in the first aspect.
  • the inventors of the present disclosure have found that when the moisturizing components are applied to different skin care products or cosmetics, their content will vary in order to obtain an excellent moisturizing effect. in particular:
  • the content of the polyol when the content of polyol is too low, the effect of increasing the water content on the skin surface cannot be achieved, and when the content of polyol is too high, other components are too low, although it can increase the water content on the skin surface. effect, but will affect the skin feel and cost of the product.
  • the content of the polyol is 1%-10%, preferably 2%-5%, such as 2%, 3%, 4%, 5%, based on 100% of the total mass of the skin repairing cream. %, 6%, 7%, 8%, 9%, etc.
  • the hyaluronic acid or its salt may be high molecular weight hyaluronic acid or its salt, or may be low molecular weight hyaluronic acid or its salt; specifically, the weight of the hyaluronic acid or its salt
  • the average molecular weight is below 1.8 million Daltons, preferably, the weight-average molecular weight of the large molecular weight hyaluronic acid or its salt is 1 million-1.8 million Daltons, and the weight-average molecular weight of the small molecular weight hyaluronic acid or its salt is 5,000 -10,000 Daltons of hyaluronic acid or its salts.
  • the hyaluronic acid or its salt is added in an amount of 0.01%-0.3%, preferably 0.05%-0.3%, such as 0.02%, 0.03%, based on 100% of the total mass of the skin repair cream.
  • % 0.04%, 0.06%, 0.07%, 0.08%, 0.19%, 0.1%, 0.11%, 0.12%, 0.13%, 0.14%, 0.15%, 0.16%, 0.17%, 0.18%, 0.19%, 0.2%, 0.21%, 0.22%, 0.23%, 0.24%, 0.25%, 0.26%, 0.27%, 0.28%, 0.29%, etc.
  • the added amount of the ceryl ester is 0.01%-1%, preferably 0.1%-0.5%, such as 0.05%, 0.1%, 0.2% %, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, etc.
  • the anti-inflammatory repair component of the present disclosure may include one or a combination of two or more of madecassoside, polypeptide, patchouli leaf extract, and salvia miltiorrhiza extract.
  • Madecassoside is a white powder with antipruritic, reddening and discomfort-relieving effects, effectively reducing the release of pro-inflammatory cytokines interleukin-1 ⁇ and interleukin-8 ⁇ , slowing down inflammatory responses while protecting cells from active
  • the damage of oxygen free radicals reduces the synthesis of matrix metalloproteinase-1 and promotes the production of collagen I.
  • the content of the madecassoside is 0.01%-1%, for example: 0.02%, 0.05%, 0.08%, 0.1%, 0.2% %, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, etc.
  • the content of madecassoside is in the range of 0.01%-1%, it has good effects of reducing inflammation and redness and alleviating discomfort.
  • Polypeptide is a compound formed by linking ⁇ -amino acids together with peptide bonds, and it is also an intermediate product of proteolysis.
  • the compound formed by the dehydration and condensation of two amino acid molecules is called dipeptide, and there are also tripeptide, tetrapeptide, pentapeptide, etc. by analogy.
  • Compounds usually formed by dehydration and condensation of three or more amino acid molecules can be called polypeptides.
  • the present disclosure further enhances the anti-inflammatory repairing efficacy of the skin repairing special cream by using polypeptides.
  • the content of the polypeptide is 0.01%-5%, for example: 0.1%, 0.3%, 0.5%, 0.8%, 1.2%, 1.5% , 1.8%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, etc.
  • the content of the polypeptide is in the range of 0.01%-5%, it has a good bactericidal effect, thereby improving the anti-inflammatory repair effect.
  • the polypeptides of the present disclosure include oligopeptide-1 and/or palmitoyl tetrapeptide-7.
  • Oligopeptide-1 is a synthetic polypeptide composed of glycine, histidine and lysine. It can promote the growth of injured skin tissue, has a good effect on the healing of skin ulcers, and provides nutrition for skin repair. Palmitoyl Tetrapeptide-7 (Palmitoyl Tetrapeptide-7) can delay and inhibit the production of excessive cellular interleukins, thereby inhibiting some unnecessary and inappropriate inflammatory responses and glycosylation damage.
  • Patchouli Leaf Extract contains a variety of compounds, including terpenoids, flavonoids, phenylpropanoids, steroids and alkaloids, which are used in antibacterial, anti-inflammatory, anti-allergic, immunomodulatory and other potential medicinal value.
  • the content of the patchouli leaf extract is 0.01%-2%, preferably 0.5%-1%; for example: 0.1%, 0.3%, 0.8% , 1.2%, 1.5%, 1.8%, etc.
  • the content of the patchouli leaf extract is 0.01%-2%, it can play an excellent anti-inflammatory effect.
  • Salvia Miltiorrhiza (SALVIA MILTIORRHIZA) extract is a phenanthrenequinone derivative.
  • the extract In the culture of fibroblasts, etc., the extract has a good promoting effect on the proliferation of collagen, so it can enhance the metabolism of the dermis of the skin, and also has antibacterial and anti-inflammatory effects.
  • the content of the Salvia miltiorrhiza extract is 0.1%-5%, preferably 0.2%-2%, for example: 0.3%, 0.5%, 0.8% , 1.2%, 1.5%, 1.8%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, etc.
  • the content of Salvia miltiorrhiza extract is in the range of 0.1%-5%, it has good bactericidal and anti-inflammatory effects, and also has the effect of revitalizing the skin.
  • Barrier repair components of the present disclosure may include ceramides and/or phytosterol canola glycerides.
  • Ceramide is the main component of lipids in the stratum corneum of the skin, which can help repair the skin barrier and make the skin soft and shiny. Ceramide can not only resist external stimuli, but also thicken the stratum corneum, improve the tolerance of the entire skin, avoid sensitivity and repair red blood. It is an excellent barrier repair component.
  • the content of the ceramide is 0.01%-1%, preferably 0.3-0.6%, for example: 0.02%, 0.05%, 0.08%, 0.1%, based on the total mass of the skin repairing cream is 100% %, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, etc.
  • the added amount of ceramide is 0.01%-1%, it can effectively resist external stimuli, and can thicken the stratum corneum, improve the tolerance of the entire skin, avoid sensitivity and repair red blood.
  • Phytosteryl Canola Glycerides are suitable for sensitive skin to improve water retention in dry skin and protect skin from environmental hazards.
  • the content of the phytosterol canola oil glycerides is 0.1%-5%, preferably 0.5%-2%, based on 100% of the total mass of the skin repair cream, for example: 0.3%, 0.5%, 0.8%, 1.2%, 1.5%, 1.8%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, etc.
  • the content of the phytosterol canola oil glyceride is 0.1%-5%, it can better synergize with ceramide, so as to repair the skin barrier.
  • the skin repair cream of the present disclosure may further include one or a combination of two or more of emulsifiers, emollient oils, thickeners and preservatives.
  • the content of the emulsifier is 0.1-1%; the content of the emollient oil is 1%-10%, the content of the thickener is 0.3%-1%, and the content of the preservative is 0.1%-1%.
  • the amount of the emulsifier added is 0.1-1%, for example: 0.2%, 0.3%, 0.4%, 0.5% based on 100% of the total mass of the skin repair cream. %, 0.6%, 0.7%, 0.8%, 0.9%, etc.
  • the dosage of the emulsifier in the present application is too low, the emulsification is insufficient and the system is unstable; when the dosage of the emulsifier is too high, the stability of the product will also be affected to a certain extent.
  • the type of emulsifier is not particularly limited in the present disclosure, and can be some emulsifiers commonly used in the art.
  • the emulsifier includes one or more of hydrogenated lecithin, PEG-20 methylglucose sesquistearate, and methylglucose sesquistearate, etc. The combination.
  • the content of the thickener is 0.3%-1%, preferably 0.5-0.8%, for example: 0.4%, based on 100% of the total mass of the skin repair cream , 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, etc.
  • the skin conditioning cream of the present disclosure can be made to have a suitable consistency.
  • the type of thickener is not particularly limited in the present disclosure, and can be some commonly used thickeners in the art.
  • the thickener includes carbomer, ammonium acryldimethyltaurate/VP copolymer, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer a combination of one or two or more.
  • the content of the emollient oil is 1%-10%, preferably 2%-5%, based on 100% of the total mass of the skin repair cream, for example: 2 %, 3%, 4%, 5%, 6%, 7%, 8%, 9%, etc.
  • Adding emollient oils to the skin repair cream can reduce the evaporation of moisture on the skin's surface and prevent dry and cracked skin.
  • a hydrophobic film can be formed on the skin surface to prevent the intrusion of external harmful substances.
  • the type of emollient oil is not particularly limited in the present disclosure, and may be some thickeners commonly used in the art.
  • the emollient oil includes one of dimethicone, shea butter, caprylic/capric triglyceride, dimethiconol, and squalane one or a combination of two or more.
  • the skin repair cream of the present disclosure may further contain pH adjusters, preservatives, and the like.
  • the contents of pH adjusters and preservatives are not particularly limited in the present disclosure, and may be added as needed.
  • the addition amount of the pH adjuster is not particularly limited in the present disclosure.
  • the pH adjuster By adding the pH adjuster, the pH of the skin repairing cream of the present disclosure can be neutralized.
  • the content of the preservative generally not exceeding the regulations of the cosmetic industry, specifically, the content of the preservative can be 0.1%-1%, preferably 0.5%-0.8%.
  • the pH adjusting agent may be a pH adjusting agent commonly used in the art, such as aminomethyl propanol and the like.
  • the third aspect of the present disclosure also provides a method for preparing a skin repairing special cream, which includes the step of mixing each component of the skin repairing special cream.
  • the preparation method of the skin repairing special cream of the present disclosure comprises the following steps:
  • Step 1) The moisturizing component, the optional thickener and the optional deionized water are mixed and recorded as phase A, and the barrier repair component, the optional emollient oil and the optional emulsifier are mixed and recorded.
  • phase B For phase B.
  • Step 2) Mix the two phases A and B evenly and heat them to 80-85° C. respectively, and then add the B phase to the A phase to make the mixture uniform.
  • Step 3 Lower the whole system to 45°C, add the anti-inflammatory repair component, optional preservative, optional pH adjuster, stir evenly to normal temperature, and then discharge.
  • a fourth aspect of the present disclosure provides a foundation composition, based on 100% of the total mass of the foundation composition, comprising the following composition:
  • Concealer component 28.4%-70.8%, preferably 30%-65%;
  • Repair component 0.91%-3.6%, preferably 1%-3%;
  • Moisturizing component 3%-10%, preferably 4%-9%;
  • Soothing components 0.3%-6%, preferably 1-3%.
  • the foundation composition of the present disclosure has strong skin repairing effect, excellent moisturizing effect, and still has excellent concealing ability.
  • a concealer component is included in the foundation composition of the present disclosure. Due to the presence of the concealer component, the foundation composition of the present disclosure can play the role of even skin tone and adjust skin color when applying foundation makeup, and can make the skin look more natural and even. In addition, the foundation composition of the present disclosure has strong concealing ability, especially excellent concealing ability for fine lines and pigmentation spots.
  • the content of the concealer component is 28.4%-70.8%, preferably 30-65%, more preferably 30%-60%; for example: the The content of concealer components is 25%, 28%, 32%, 35%, 38%, 40%, 42%, 45%, 48%, 50%, 52%, 55%, 58%, 60%, 62% , 65%, 68%, 70%, etc.
  • the foundation composition basically has no covering power and only a slight brightening effect; if the content of the concealer component is higher than 70.8%, the powdery phenomenon may occur .
  • the concealer component of the present disclosure includes titanium dioxide; the present disclosure enables the foundation composition of the present disclosure to have a certain covering effect by using the titanium dioxide, thereby having a certain concealing function.
  • the average particle size of the titanium dioxide is 50nm-200nm.
  • the present disclosure preferably uses titanium dioxide with different average particle sizes, such as titanium dioxide with an average particle size of 50-99 nm, titanium dioxide with an average particle size of 100-149 nm, titanium dioxide with an average particle size of 150-200, and the like.
  • titanium dioxide with larger particle size has strong covering power
  • titanium dioxide with intermediate particle size has a certain covering power
  • titanium dioxide with small particle size has weak covering power, but good adherence.
  • the content of the titanium dioxide may be 12%-24%, preferably 12%-18%; for example: the content of the titanium dioxide 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, etc.
  • the concealer effect is excellent.
  • the concealer component further includes one or a combination of two or more of pigments, dispersants, emollient oils, elastomers, silica and film-forming agents; Based on 100% mass, the content of the pigment is 0.1%-1.5%, the content of the dispersant is 0.3%-1.5%, the content of the emollient oil is 10-28.8%, and the content of the elastomer The content of the film-forming agent is 2%-5%; the content of the silica is 2%-5%.
  • the makeup is sticky or not is a criterion for evaluating the quality of the base makeup.
  • the addition of a dispersant helps to disperse the powder components.
  • the present disclosure can better help the powder to stick to the makeup during makeup by using the dispersant.
  • the content of the dispersant is 0.3-1.5%, for example: the content of the dispersant is 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, etc.
  • the content of the dispersant is 0.3-1.5%, the skin feels lighter, the powder is evenly dispersed, and the adhesiveness is good.
  • the dispersing agent includes one or both of polyhydroxystearic acid and polyglycerol-3 diisostearate.
  • the addition of the elastomer can have the effect of invisible pores.
  • the content of the elastomer is 2%-5%, for example: the content of the elastomer is 2.2%, 2.5%, 2.8%, 3%, 3.2% , 3.5%, 3.8%, 4%, 4.2%, 4.5%, 4.8%, etc.
  • the elastomers include dimethicone/vinyl dimethicone crosspolymer, polysiloxane-11 and HDI/trihydroxycaprolactone crosspolymer One or a combination of two or more.
  • makeup durability after makeup is also a key concern area, and the addition of a film-forming agent contributes to the makeup persistence after makeup.
  • the content of the film-forming agent is 2%-5%, for example: the content of the film-forming agent is 2.2%, 2.5%, 2.8%, 3%, 3.2%, 3.5%, 3.8%, 4%, 4.2%, 4.5%, 4.8%, etc.
  • the film-forming agent includes one or a combination of two or more of trimethylsiloxysilicate, stearic acid citrate, and tris(octyldodecanol) citrate.
  • the color of the foundation composition is adjusted through the use of pigments to bring the foundation composition closer to the skin tone.
  • the content of the pigment is 0.1%-1.5%, for example: the content of the pigment is 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7% %, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, etc.
  • the pigment includes one or a combination of two or more of iron yellow, iron red and iron black.
  • the present disclosure improves the skin feel of the powder-liquid composition by using an emollient oil, and can play a moisturizing effect.
  • the content of the emollient oil is 10-28.8%, for example: the content of the emollient oil is 12%, 15%, 18%, 20%, 22% %, 25%, 28%, etc.
  • the emollient oils include dioctyl carbonate, isododecane, dimethicone, phenyl trimethicone, hydrogenated polyisobutylene, C12-15 alcohol One or a combination of two or more of benzoate, glycerol tri(ethylhexanoate), dioctyl carbonate, and diisostearyl malate.
  • the concealer component of the present disclosure further contains silica, and the use of silica helps to increase slippery feel and remove oily feel, making it easier to push off when applying makeup.
  • the content of the silica is 2-5%, for example, the content of the silica is 2.2%, 2.5%, 2.8%, 3%, 3.2%, 3.5%, 3.8%, 4%, 4.2% , 4.5%, 4.8%, etc.
  • the present disclosure uses a repairing component, so that the foundation composition of the present disclosure has a certain repairing effect while having covering power.
  • the content of the repairing component is 0.91%-3.6%, preferably 1%-3%; for example: the repairing component
  • the content of the protective component is 1%, 1.2%, 1.5%, 1.8%, 2%, 2.2%, 2.5%, 2.8%, 3%, 3.2%, 3.5%, etc.
  • the repairing component of the present disclosure is less than 0.91%, the user cannot feel the repairing effect; when the content of the repairing component is higher than 3.6%, there will be adverse reactions such as heavy skin feeling, pimples, irritation, etc. .
  • the repair component may include one or a combination of two or more of essential oils, ceramides, and phytosterol canola glycerides; wherein, the total mass of the foundation composition is 100 %, the content of the essential oil can be 0.4%-1.4%, the content of the ceramide can be 0.01%-0.5%, the content of the phytosterol canola oil can be 0.5-1.7%; preferably Preferably, the essential oil includes one or a combination of two or more of lavender essential oil, tea tree essential oil and sweet orange essential oil.
  • essential oils can improve oily skin, remove keratinocytes, maintain skin elasticity, and effectively improve circulatory disorders.
  • essential oils can promote sleep, prevent wrinkles, eliminate dark circles, and help fade dark spots.
  • lavender oil and tea tree essential oil have strong antibacterial and anti-inflammatory effects, and have repairing effects on damaged skin.
  • sweet orange essential oil has antioxidant properties and can be used in the care of dry and aging skin.
  • the content of the essential oil is 0.4%-1.4%; for example, the content of the essential oil is 0.45%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.35%, etc.
  • the essential oil content is 0.4%-1.4%, it can control oil and promote blood circulation. And long-term use can achieve the effect of skin care.
  • the inventors of the present disclosure found that the combination of lavender essential oil, tea tree essential oil and sweet orange essential oil has a synergistic effect and can further play a repairing effect.
  • the content of lavender essential oil is 0.3%-1%, for example: the content of the lavender essential oil is 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, etc.; the content of tea tree essential oil is 0.05%-0.2%; for example: the content of the tea tree essential oil is 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.11%, 0.12%, 0.13% %, 0.14%, 0.15%, 0.16%, 0.17%, 0.18%, etc.; the content of the sweet orange essential oil is 0.05%-0.2%; the content of the sweet orange essential oil is 0.06%, 0.07%, 0.08%, 0.09 %, 0.1%, 0.11%, 0.12%, 0.13%, 0.14%, 0.15%, 0.16%, 0.1
  • ceramides are the main components constituting the lipids of the stratum corneum of the skin, and the present disclosure helps to repair the skin barrier by appropriately adding some ceramides, thereby making the skin soft and shiny. Ceramide can not only resist external stimuli, but also thicken the stratum corneum, improve the tolerance of the entire skin, avoid sensitivity and repair red blood. It is an excellent barrier repair component.
  • the content of the ceramide is 0.01%-0.5%; for example, the content of the ceramide is 0.03%, 0.05%, 0.08% %, 0.1%, 0.12%, 0.15%, 0.18%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, etc.
  • the content of ceramide is 0.01%-0.5%, it helps to repair the skin barrier, and the cost is not too high, and the long-term use effect is better.
  • phytosterol canola oil glycerides are synthetic products of canola glycerides and phytosterols, and also have the effect of forming a sebum film and promoting the secretion of ceramides from the skin.
  • the content of the phytosterol canola glyceride is 0.5%-1.7%; for example, the content of the phytosterol canola glyceride is 0.6%, 0.7%, 0.8% , 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, etc.
  • the content of phytosterol canola glyceride is 0.5%-1.7%, the skin does not feel heavy and has excellent repairing effect.
  • the foundation composition of the present disclosure also has moisturizing effect.
  • the content of the moisturizing component is 3%-10%, preferably 4%-9%, for example: the content of the moisturizing component 4%, 4.5%, 5%, 5.5%, 6%, 6.5%, 7%, 7.5%, 8%, 8.5%, etc. If the content of the moisturizing component of the present disclosure is less than 3%, the moisturizing feeling after applying makeup will be reduced, and the phenomenon of dryness and peeling may easily occur after applying makeup; if the content of the moisturizing component of the present disclosure is higher than 10% Does not dry out quickly.
  • the moisturizing components of the present disclosure include polyols, hyaluronic acid or salts thereof, and ceramides.
  • the moisturizing component can effectively increase the moisture content of the skin epidermis, can achieve deep moisturizing in essence, and can have an excellent moisturizing effect when applied in the foundation composition of the present disclosure.
  • the polyol, hyaluronic acid or its salt, and ceryl lipid in the moisturizing component of the fourth aspect of the present disclosure are the same as the polyol, hyaluronic acid or its salt, and ceryl lipid in the first aspect.
  • the inventors of the present disclosure have found that when the moisturizing components are applied to different skin care products or cosmetics, their content will vary in order to obtain an excellent moisturizing effect. in particular:
  • the polyol content is 2.88%-8.8%, for example, the polyol content is 3%, 3.5%, 4%, 4.5%, 5% , 5.5%, 6%, 6.5%, 7%, 7.5%, 8.5%, etc.
  • the weight average molecular weight of the hyaluronic acid or its salt may be 1.8 million Daltons or less, preferably 1 million-1.8 million Daltons.
  • the amount of the hyaluronic acid or its salt added is 0.02%-0.2%, for example, the content of the hyaluronic acid or its salt is 0.04% , 0.06%, 0.08%, 0.1%, 0.12%, 0.14%, 0.16%, 0.18%, etc.
  • the addition amount of the ceryl ester of the fourth aspect of the present disclosure is 0.1%-1%, for example: the content of the ceryl ester is 0.15%, 0.2% %, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5%, 0.55%, 0.6%, 0.65%, 0.7%, 0.75%, 0.8%, 0.85%, 0.9%, 0.95%, etc.
  • the present disclosure makes the foundation composition of the present disclosure also have a soothing effect by appropriately adding some soothing components.
  • the content of the soothing component is 0.3%-6%, preferably 1%-3%, for example: the content of the soothing component 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 5.5%, etc.
  • the content of the soothing component is less than 0.3%, the effect is not obvious, and if the content of the soothing component exceeds 6%, the cost is too high.
  • the soothing component includes one or a combination of two or more of Cactus spinosa extract, Scutellaria baicalensis extract, Madecassoside, and Patchouli leaf extract or a combination of two or more.
  • the soothing component comprises one or a combination of two or more of the Cactus spinosa extract, Scutellaria baicalensis extract, Madecassoside, and Patchouli leaf extract.
  • the soothing effect will be more excellent.
  • the soothing components of the present application include a combination of Cactus spinosa extract, Scutellaria baicalensis extract and patchouli leaf extract; preferably, Based on the total mass of the foundation composition as 100%, the content of the thorn prickly pear extract is 0.1%-3%; specifically, the content of the prickly prickly pear extract is 0.3%, 0.5%, 0.8% %, 1%, 1.2%, 1.5%, 1.8%, 2%, 2.2%, 2.5%, 2.8%, etc.; the content of the Scutellaria baicalensis extract is 0.1%-1.8%; The content is 0.2%, 0.5%, 0.8%, 1%, 1.2%, 1.5%, 1.8%, etc.; the content of the patchouli leaf extract is 0.1%-1.2%; The content of the extract is 0.2%, 0.5%, 0.8%, 1%, 1.2% and so on.
  • the foundation composition of the present disclosure may further include one or a combination of two or more of emulsifiers, thickeners, inorganic salts, preservatives, and solvents.
  • the content of the emulsifier is 3%-7%, preferably 4%-6%; the content of the thickener is 0%-0.4% %, preferably 0.1%-0.2%; the content of the inorganic salt is 0.5%-1.2%, preferably 0.7%-1%; the content of the preservative is 0.5%-1.0%, preferably 0.6%-0.8 %; the general balance is solvent, specifically, the content of the solvent can be 0%-63.39%, preferably 12%-58.6%.
  • the emulsifier may include sorbitan isostearate, PEG/PPG-20/14 dimethicone, PEG-10 dimethicone, polyglycerol -3
  • the thickener may include xanthan gum and/or ammonium acryloyldimethyltaurate/VP copolymer.
  • the inorganic salts may include inorganic salts commonly used in skin care products such as magnesium sulfate.
  • the preservative may include one or a combination of two or more of phenoxyethanol, methylparaben, and ethylhexylglycerol.
  • a fourth aspect of the present disclosure also provides a method for preparing a foundation composition according to the fourth aspect of the present disclosure, which includes the step of mixing each component of the foundation composition.
  • the preparation method comprises the following steps:
  • Part of the concealer and the emulsifier are ground through a colloid mill until they are uniformly dispersed to obtain a premix;
  • preparation method comprises the following steps:
  • Part of the concealer and the emulsifier are ground by a colloid mill for 1-5 times until they are uniformly dispersed to obtain a premix;
  • the temperature is lowered to below 40° C., and the remaining repair components and preservatives are added into the remix to obtain a foundation composition.
  • ceryl ester purchased from Guangdong Modern Kampo Technology Co., Ltd., and its main characters are shown in Table A below:
  • the manufacturer of madecassoside is French company Saibiq;
  • Twisted thorn cactus extract Beijing Huaxia Zhongfang Biotechnology Co., Ltd.;
  • Salvia miltiorrhiza extract The manufacturer of Salvia miltiorrhiza extract is Dongfang Miaosen Biotechnology Co., Ltd.;
  • phytosterol canola oil glycerides The manufacturer of phytosterol canola oil glycerides is AKK Nordic Oil Group;
  • the manufacturer of Scutellaria baicalensis extract is DSM of the Netherlands;
  • High molecular weight sodium hyaluronate 1 million-1.8 million Daltons, manufacturer: Huaxi Biotechnology Co., Ltd.;
  • Titanium dioxide is divided into three types according to the average particle size, specifically titanium dioxide with an average particle size of 50nm, titanium dioxide with an average particle size of 100nm and titanium dioxide with an average particle size of 150nm.
  • the sample A of Comparative Example 1.1 was selected as the test sample, and two areas were selected in the inner forearm area of the volunteer, each area was 3.0cm ⁇ 3.0cm, and the sample dosage of one area was (2.0 ⁇ 0.1) mg/cm 2 (ie 0.0171g ⁇ 0.0189g) as the test area, the other area does not apply the product.
  • the water content of the stratum corneum at the beginning of the test area and 2 hours and 4 hours after applying the product was measured as the value of the sample, and the water content of the stratum corneum in the area without the product was measured at the beginning, 2 hours and 4 hours as a blank control. Results As shown in Table 1.4.
  • the samples BC of Comparative Examples 1.2-1.3 were selected as the test samples, and three regions were selected in the inner forearm area of the volunteers, each with a size of 3.0cm ⁇ 3.0cm, two of which used sample B and sample C respectively. (2.0 ⁇ 0.1) mg/cm 2 (ie, 0.0171g ⁇ 0.0189g) was used as the test area, and the other area did not apply the product.
  • the water content of the stratum corneum at the beginning of the test area and 2 hours and 4 hours after applying the product was measured as the value of the sample, and the water content of the stratum corneum in the area without the product application at the beginning, 2 hours and 4 hours was measured as a blank control, wherein , test sample B and sample C at the same time, and select the same area as a blank control, the results are shown in Table 1.5.
  • the sample DF of Comparative Example 1.4-1.6 was selected as the test sample, and two areas were selected in the inner forearm area of the volunteer, each area was 3.0cm ⁇ 3.0cm, and the sample dosage of one area was (2.0 ⁇ 0.1)mg/ cm 2 (ie, 0.0171g-0.0189g) is used as the test area, and the other area is not applied with the product.
  • the water content of the stratum corneum at the beginning of the test area and 2 hours and 4 hours after applying the product was measured as the value of the sample, and the water content of the stratum corneum in the area without the product was measured at the beginning, 2 hours and 4 hours as a blank control. Results As shown in Table 1.6.
  • samples A-E basically have no moisturizing effect. It can be seen that the simple sodium hyaluronate aqueous solution and the D-panthenol aqueous solution cannot increase the moisture content of the epidermis.
  • the sample ce of embodiment 1.3-1.5 was selected as the test sample, and four regions were selected in the inner region of the volunteer forearm, and the size of each region was 3.0cm ⁇ 3.0cm, and the sample ce was used in the three regions respectively, and the sample consumption was ( 2.0 ⁇ 0.1) mg/cm 2 (ie, 0.0171g ⁇ 0.0189g) as the test area, and the other area does not apply the product.
  • Example 1.6-1.7 The sample fg of Example 1.6-1.7 was selected as the test sample, and three areas were selected in the inner forearm area of the volunteer, each area was 3.0cm ⁇ 3.0cm, and the sample f and the sample g were used in the two areas respectively. (2.0 ⁇ 0.1) mg/cm 2 (ie, 0.0171g ⁇ 0.0189g) was used as the test area, and the other area did not apply the product.
  • the water content of the stratum corneum at the beginning of the test area and 2 hours and 4 hours after applying the product was measured as the value of the sample, and the water content of the stratum corneum in the area without the product application at the beginning, 2 hours and 4 hours was measured as a blank control, wherein , test sample B and sample C at the same time, and select the same area as a blank control, the results are shown in Table 1.9.
  • Example 1.8 Select 20-30 year old female subjects for moisturizing test.
  • the sample h of Example 1.8 was selected as the test sample, and two areas were selected in the inner forearm area of the volunteer, each area was 3.0cm ⁇ 3.0cm, and the sample dosage of one area was (2.0 ⁇ 0.1) mg/cm 2 (ie 0.0171g ⁇ 0.0189g) as the test area, the other area does not apply the product.
  • the water content of the stratum corneum at the beginning of the test area and 2 hours and 4 hours after applying the product was measured as the value of the sample, and the water content of the stratum corneum in the area without the product was measured at the beginning, 2 hours and 4 hours as a blank control. Results As shown in Table 1.10.
  • the moisturizing cream is prepared according to the formula shown in Table 2.1, and the specific preparation steps are as follows:
  • the samples F1-1, F1-2 of Application Examples 2.1-2.2 and the application control group were selected as test samples.
  • Four areas were selected from the inner forearm area of the volunteers, each area was 3.0cm ⁇ 3.0cm, and three areas were respectively used samples F1-1, F1-2 and the application control group, and the sample dosage was (2.0 ⁇ 0.1 ) mg/cm 2 (ie, 0.0171g ⁇ 0.0189g) as the test area, and the other area does not apply the product.
  • sample F1-3 of Application Example 2.3 was selected as the test sample.
  • Two regions were selected from the inner forearm of the volunteers, each with a size of 3.0cm ⁇ 3.0cm, and sample F1-3 was used in one of the regions, and the dosage was (2.0 ⁇ 0.1) mg/cm 2 (ie, 0.0171g ⁇ 0.0189g) As a test area, another area is left unapplied with product.
  • the temperature is raised to 80-85°C, and the B phase is added to the A phase, and the temperature is lowered after the homogenization is uniform.
  • phase C and premixed phase D are added in sequence, and the mixture is discharged after stirring evenly.
  • the skin repairing cream was prepared according to the above method.
  • the temperature is raised to 80-85 °C, and the B phase is added to the A phase. After the homogenization is uniform, the temperature is lowered until the whole system is continuously stirred and cooled to below 45 °C. Mixed phase D, stir well and then discharge.
  • the skin repairing cream was prepared according to the above method.
  • Examples 3.1-3.7 and Comparative Examples 3.1-3.4 as test samples, 20 female subjects aged 20-30 who had experienced allergic phenomena were selected for testing in each group, and they were used on the face every morning and evening, and the usage amount was (2.0 ⁇ 0.1) mg/cm 2 (ie, 0.0171 g to 0.0189 g).
  • a questionnaire was used to test the skin condition of the subjects after 7 days of use. The soothing and repairing effect was counted as 10 points, with 0 points representing no effect and 10 points representing significant improvement in dry skin or acne symptoms. The results are shown in Table 3.4 and Table 3.5. Show.
  • Example 1 Example 2
  • Example 3 Example 4
  • Example 5 Example 6
  • Example 7 1 6 6 4 6 7 8 8 2 5 5 4 6 7 6 7 3 5 7 5 7 7 7 7 7 4 5 5 3 6 6 6 7 5 6 6 6 5 8 6 6 6 4 4 2 5 7 7 5 7 5 5 4 6 5 8 6 8 4 3 4 5 6 7 6 9 4 3 2 2 5 8 7 10 5 6 5 6 6 7 8 11 4 4 3 5 6 8 7 12 4 6 6 6 7 8 7 13 5 3 4 4 6 7 7 14 3 5 4 6 6 7 6 15 5 5 4 5 7 7 8 16 5 5 3 5 7 8 8 17 4 3 3 2 8 7 7 18 5 6 4 6 7 9 8 19 5 5 5 5 8 7 8 20 4 5 4 6 7 7 7 8 average value 4.9 4.85 3.95 5.2 6.65 7.25 7.05
  • Example 3.1 0 0 30 Example 3.2 0 0 30
  • Example 3.4 0 0 30 Example 3.5 0 0 30
  • Comparative Example 3.2 0 0 30 Comparative Example 3.3 0 0 30 Comparative Example 3.4 1 4 25 Comparative Example 3.5 0 0 30
  • Examples 3.1-3.7 and Comparative Examples 3.1-3.5 as test samples, female subjects aged 20-30 were selected for moisturizing test.
  • the medial area of the volunteer's forearm, each area is 3.0cm ⁇ 3.0cm, and the sample dosage is (2.0 ⁇ 0.1) mg/cm 2 (ie, 0.0171g-0.0189g).
  • the water content of the stratum corneum was measured at the beginning and after 2 hours and 4 hours of using the product as the value of the sample, and the results are shown in Table 3.7.
  • the testers with numbers 1-10 carried out the tests of Examples 3.1-3.3; the testers with numbers 11-20 carried out the tests of Examples 3.4-3.6; the testers with numbers 21-30 carried out the tests of Examples 3.7 and Comparative Examples 3.1- Tests of 3.2; Testers No. 31-40 performed tests of Comparative Examples 3.3-3.5.
  • test samples female subjects aged 20-30 were selected for moisturizing test.
  • the medial area of the volunteer's forearm, each area is 3.0cm ⁇ 3.0cm, and the sample dosage is (2.0 ⁇ 0.1) mg/cm 2 (ie, 0.0171g-0.0189g).
  • the water content of the stratum corneum at the initial stage and after using the product for 28 days was measured as the value of the sample, and the results are shown in Table 3.8.
  • the preparation method of the liquid foundation in the embodiment comprises the following steps:
  • phase B and phase C 1) Add phase B and phase C to phase A, stir and heat to 80-85°C, and then drop to 60°C after homogenization.
  • Comparative Example 4.2 and Examples 4.1-4.13 as test samples, 14 groups were selected, and each group was tested by 20 female subjects aged 20-30 who rated themselves as dry sensitive skin. Take about 0.3g, apply it to the face, and dab it with a beauty egg. Questionnaires were used to collect whether the subjects experienced irritation, dryness, itching, etc. within 8 hours after wearing makeup. The results are shown in Table 4.6.
  • Example 4.2 20 0 20 Example 4.3 20 0 20
  • Example 4.4 20 0 20 Example 4.5 20 0 20
  • Example 4.6 20 0 20 Example 4.7 20 0 20
  • Example 4.8 20 0 20 Example 4.9 20 2 18
  • Example 4.10 20 4 16 Example 4.11 20 3 17
  • Comparative Example 4.1 and Examples 4.1-4.5 as test samples, 14 groups were selected, and each group was tested by 10 female subjects aged 20-30 who rated themselves as dry sensitive skin. Take about 0.3g every day and apply it to the face. , dab the makeup egg on. In the form of a questionnaire, it was tested whether the subjects had card powder when using, and whether there was dry peeling within 8 hours after use. The results are shown in Table 4.7.
  • the moisturizing composition, skin repairing cream, foundation composition and preparation method thereof provided according to the embodiments of the present disclosure can be applied to the fields of skin care products and cosmetics, and can effectively play a moisturizing role.

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Abstract

本公开提供一种保湿组合物、皮肤修护特护霜、粉底组合物及其制备方法。其中，以所述保湿组合物的总质量为100％计，保湿组合物包括以下组分：多元醇：60％～99.8％，优选为70％～94％；透明质酸或其盐：0.1％～10％，优选为0.3％～5％；神经酰脂：0.1％～30％，优选为1.5％～25％。本公开的保湿组合物能够提高皮肤表皮含水量，能够从本质上达到深层保湿，当将其应用在化妆品或护肤品中时，能够具有优异的保湿效果。本公开的保湿组合物的制备方法简单易行，原料易于获取，适合大批量生产。

Description

保湿组合物、皮肤修护特护霜、粉底组合物及其制备方法 技术领域
本公开涉及一种保湿组合物、皮肤修护特护霜、粉底组合物及其制备方法，属于化妆品领域。
背景技术
皮肤角质层作为一个连续型的皮肤屏障，主要由角质细胞及其细胞外质构成。角质细胞内质中主要含有丰富的蛋白质和多种天然保湿因子，其细胞外质则由胆固醇、神经酰胺、游离脂肪酸等脂质构成。这些物质的存在既能有效阻止体内的水分流失也能阻止外界的有害物质侵蚀。若角质层含水量低则会出现皮肤干裂、粗糙等现象，因此化妆品内常使用多种保湿剂达到保持补充皮肤水分的效果。现用的保湿剂可分为四类，小分子保湿剂、高分子保湿剂、封闭性油脂及新型高效保湿剂。单从水剂看，常见的小分子保湿剂有甘油、丁二醇、丙二醇等。常见的高分子保湿剂则包括透明质酸钠、多糖等。
其中，甘油分子量小，能够在皮肤表面形成一层致密的保护膜，使用甘油所做的保湿剂及油脂对保湿性能影响的研究发现，单纯使用甘油具有明显的保湿效果，随甘油含量的增加，表皮水分含量增大。但是，甘油用量过大时，会产生黏腻感。
透明质酸是人体真皮层中的一种成分，具备保持水分的能力，分量更高达其本身重量的100倍，使用含有透明质酸HA的保养品，可以改善干燥和已出现皱纹的肌肤，使其复原有的光滑和弹性，因此，透明质酸是改善干燥及老化肌肤的最理想产品。但根据实验数据显示，0.05％-0.2％的透明质酸的水溶液并没有明显的保湿效果。这其中存在的原因可能是透明质酸分子结构大，涂抹在皮肤后易发生团聚；另外，透明质酸羟基基团多，在皮肤表面的黏附主要依靠羟基的氢键作用力，而当羟基无法向外界吸收水分时，则不能使表皮含水量增大。
发明内容
技术问题
有鉴于此，本公开要解决的技术问题是提供一种保湿组合物，该保湿组合物能够提高皮肤表皮含水量，能够从本质上达到深层保湿，当将其应用在化妆品或护肤品中时，能够具有优异的保湿效果。
进一步地，针对修护皮肤屏障、控制皮肤炎症以及补水保湿不能兼容的问题，本公开首先提供了一种皮肤修护特护霜，本公开的皮肤修护特护霜的修护皮肤屏障、控制皮肤炎症以及补水保湿均优异。
进一步地，针对干性敏感肌人群，本公开还提供一种具有皮肤修护作用的粉底组合物。本公开的粉底组合物的皮肤修护作用强，且仍然具有优异的遮瑕能力。
解决方案
本公开提供一种保湿组合物，以所述保湿组合物的总质量为100％计，包括以下组分：
多元醇：60％～99.8％，优选为70％～94％；
透明质酸或其盐：0.1％～10％，优选为0.3％～5％；
神经酰脂：0.1％～30％，优选为1.5％～25％。
根据本公开所述的保湿组合物，其中，所述多元醇、透明质酸或其盐以及神经酰脂的质量比为：100:(0.5-2.5):(1.5-25)。
根据本公开所述的保湿组合物，其中，所述多元醇包括：甘油、1,4-丁二醇、戊二醇、1,2-丙二醇、1,3-丙二醇、二丙二醇、甲基丙二醇中的一种或两种以上的组合。
根据本公开所述的保湿组合物，其中，所述保湿组合物还包括D-泛醇，优选地，以所述保湿组合物的总质量为100％计，所述D-泛醇的加入量为：0.5％～30％，优选为4～25％。
根据本公开所述的保湿组合物，其中，所述多元醇与所述D-泛醇的质量比为100：(4-25)。
本公开还提供一种根据本公开所述的保湿组合物的制备方法，其包括将所述保湿组合物的各组分混合的步骤。
本公开还提供一种皮肤修护特护霜，以所述皮肤修护特护霜的总质量为100％计，包括以下组分：
抗炎修复组分：0.13％-13％；
保湿组分：1.02％-11.2％；以及
屏障修复组分：0.11％-6％；其中
所述保湿组分包括多元醇、透明质酸或其盐和神经酰脂。
根据本公开所述的皮肤修护特护霜，其中，所述保湿组分中，以所述皮肤修护特护霜的总质量为100％计，所述多元醇的加入量为1％-10％；所述神经酰脂的加入量为0.01％-1％；所述透明质酸或其盐的加入量为0.01％-0.3％。
根据本公开所述的皮肤修护特护霜，其中，所述抗炎修复组分包括羟基积雪草苷、多肽，广藿香叶提取物、丹参提取物中的一种或两种以上的组合；
优选地，以所述皮肤修护特护霜的总质量为100％计，所述羟基积雪草苷的含量为0.01％-1％；所述多肽的含量为0.01％-5％；所述广藿香叶提取物的含量为0.01％-2％；所述丹参提取物的含量为0.1％-5％。
根据本公开所述的皮肤修护特护霜，其中，所述多肽包括寡肽-1和/或棕榈酰四肽-7。
根据本公开所述的皮肤修护特护霜，其中，所述屏障修复组分包括神经酰胺和/或植物甾醇低芥酸菜籽油甘油酯类；
优选地，以所述皮肤修护特护霜的总质量为100％计，所述神经酰胺的含量为0.01％-1％；所述植物甾醇低芥酸菜籽油甘油酯类的含量为0.1％-5％。
根据本公开所述的皮肤修护特护霜，其中，所述皮肤修护特护霜还包括乳化剂、润肤油脂、增稠剂以及防腐剂中的一种或两种以上的组合；
优选地，所述乳化剂的含量为0.1-1％；所述润肤油脂的含量为1％-10％，所述增稠剂的含量为0.3％-1％，所述防腐剂的含量为0.1％-1％。
本公开还提供一种根据本公开所述的皮肤修护特护霜的制备方法，其包括将所述皮肤修护特护霜的各组分混合的步骤。
本公开又提供一种粉底组合物，以所述粉底组合物的总质量为100％计，包括以下组成：
遮瑕组分：28.4％-70.8％，优选为30％-65％；
修护组分：0.91％-3.6％，优选为1％-3％；
保湿组分：3％-10％，优选为4％-9％；
舒缓组分：0.3％-6％，优选为1-3％；其中，
所述保湿组分包括多元醇、透明质酸或其盐和神经酰脂。
根据本公开所述的粉底组合物，其中，所述遮瑕组分包括钛白粉，以所述粉底组合物的总质量为100％计，所述钛白粉的含量为12-24％；优选地，所述钛白粉的平均粒径为50nm-200nm。
根据本公开所述的粉底组合物，其中，所述遮瑕组分还包括颜料、分散剂、润肤油脂、弹性体、硅石以及成膜剂中的一种或两种以上的组合；优选地，以所述粉底组合物的总质量为100％计，所述颜料的含量为0.1％-1.5％，所述分散剂的含量为0.3-1.5％，所述润肤油脂的含量为10-28.8％，所述弹性体的含量为2％-5％，所述成膜剂的含量为2％-5％；所述硅石的含量为2-5％。
根据本公开所述的粉底组合物，其中，所述修护组分包括精油、神经酰胺、植物甾醇低芥酸菜油甘油酯中的一种或两种以上的组合；优选地，以所述粉底组合物的总质量为100％计，所述精油的含量为0.4％-1.4％，所述神经酰胺的含量为0.01％-0.5％，所述植物甾醇低芥酸菜油甘油酯的含量为0.5-1.7％。
根据本公开所述的粉底组合物，其中，以所述粉底组合物的总质量为100％计，所述多元醇的含量为2.88％-8.8％，所述透明质酸或其盐的含量为0.02％-0.2％，所述神经酰脂的含量为0.1％-1％。
根据本公开所述的粉底组合物，其中，所述舒缓组分包括扭刺仙人掌提取物、黄芩提取物、羟基积雪草苷、广藿香叶提取物中的一种或两种以上的组合。
本公开又提供一种根据本公开所述的粉底组合物的制备方法，其包括将粉底组合物的各组分混合的步骤。
有益效果
本公开的保湿组合物能够提高皮肤表皮含水量，能够从本质上达到深层保湿，当将其应用在化妆品或护肤品中时，能够具有优异的保湿效果。
本公开的皮肤修护特护霜的不仅修护皮肤屏障、控制皮肤炎症以及补水保湿均优异，而且肤感轻薄。
本公开的粉底组合物对皮肤的修护作用强，保湿效果优异，且仍然具有优异的遮瑕能力。
具体实施方式
以下将参考附图详细说明本公开的各种示例性实施例、特征和方面。附图中相同的附图标记表示功能相同或相似的元件。尽管在附图中示出了实施例的各种方面，但是除非特别指出，不必按比例绘制附图。
在这里专用的词“示例性”意为“用作例子、实施例或说明性”。这里作为“示例性”所说明的任何实施例不必解释为优于或好于其它实施例。
另外，为了更好的说明本公开，在下文的具体实施方式中给出了众多的具体细节。本领域技术人员应当理解，没有某些具体细节，本公开同样可以实施。在另外一些实例中，对于本领域技术人员熟知的方法、手段、元件和电路未作详细描述，以便于凸显本公开的主旨。
如无特殊声明，本说明书中所使用的单位均为国际标准单位，并且本公开中出现的数值，数值范围，均应当理解为包含了工业生产中所不可避免的系统性误差。
以下，针对本公开的内容进行详细说明。以下所记载的技术特征的说明基于本公开的代表性的实施方案、具体例子而进行，但本公开不限定于这些实施方案、具体例子。
需要说明的是：
本说明书中，如没有特别说明，则“％”均表示重量百分含量。
本说明书中，使用“可以”表示的含义包括了进行某种处理以及不进行某种处理两方面的含义。
本说明书中，“任选的”或“任选地”是指接下来描述的事件或情况可发生或可不发生，并且该描述包括该事件发生的情况和该事件不发生的情况。
本说明书中，所提及的“一些具体/优选的实施方案”、“另一些具体/优选的实施方案”、“实施方案”等是指所描述的与该实施方案有关的特定要素(例如，特征、结构、性质和/或特性)包括在此处所述的至少一种实施方案中，并且可存在于其它实施方案中或者可不存在于其它实施方案中。另外，应理解，所述要素可以任何合适的方式组合在各种实施方案中。
本说明书中，使用“数值A～数值B”表示的数值范围是指包含端点数值A、B的范围。
另外，本说明书中，所述“水”包含去离子水、蒸馏水、离子交换水、双蒸水、高纯水、纯净水等化妆品领域能够使用的任何可行的水。
本说明书中，“室温”、“常温”所表达的含义是10-40℃。
<第一方面>
本公开的第一方面提供一种保湿组合物，以所述保湿组合物的总质量为100％计，包括以下组分：
多元醇：60％～99.8％，优选为70％～94％；
透明质酸或其盐：0.1％～10％，优选为0.3％～5％；
神经酰脂：0.1％～30％，优选为1.5％～25％。
本公开的保湿组合物能够有效提高皮肤表皮含水量，能够从本质上达到深层保湿，当将其应用在化妆品或护肤品中时，能够具有优异的保湿效果。
多元醇
本公开的多元醇是分子量较小的多元醇。多元醇不仅能够在皮肤表面形成一层致密的保护膜，以减少水分的流失，还能够促使本公开的保湿组合物从环境中吸收水分，补充到肌肤中，增加皮肤表面的含水量。
进一步，在本公开中所述多元醇包括：甘油、1,4-丁二醇、戊二醇、1,2-丙二醇、1,3-丙二醇、二 丙二醇、甲基丙二醇中的一种或两种以上的组合。作为优选，本公开使用甘油作为多元醇使用，当使用甘油时，可以最大程度发挥本公开的保湿组合物的效果，有效增加皮肤表面的含水量。
具体地，在本公开的第一方面中，所述多元醇的加入量为60％～99.8％，优选为70％～94％，例如62％、65％、68％、71％、73％、75％、78％、80％、82％、85％、88％、91％、95％、97％等。当多元醇的含量低于60％时，不能起到增加皮肤表面的含水量的效果，当多元醇含量高于99.8％时，导致其它成分过低，尽管可以起到增加皮肤表面的含水量的效果，但会对产品的使用肤感和成本造成影响。
透明质酸或其盐
透明质酸，又名玻尿酸，是一种酸性粘多糖。它是肌肤水嫩的重要基础物质，本身也是人体的一种成分，它具有特殊的保水作用，分量更高达其本身重量的100倍，是目前发现的自然界中保湿性最好的物质，被称为理想的天然保湿因子。它可以改善皮肤营养代谢，使皮肤柔嫩、光滑、去皱、增加弹性、防止衰老，在保湿的同时又是良好的透皮吸收促进剂。与其他营养成分配合使用，可以起到促进营养吸收的更理想效果。
在本公开的第一方面中，所述透明质酸或其盐的重均分子量可以为180万道尔顿以下，优选为100万-180万道尔顿。
一般而言，常用的透明质酸盐可以为其钠盐形式，即透明质酸钠(SODIUM HYALURONATE，简称SH)。透明质酸钠为从鸡冠中提取的物质，也可通过乳酸球菌发酵制得，为白色或类白色颗粒或粉末，无臭味，干燥时，氮含量为2.8％-4.0％，葡糖醛酸含量为37.0％-51.0％。
但是，由于透明质酸或其盐的分子结构大，涂抹在皮肤后易发生团聚；另外，透明质酸或其盐的羟基基团多，在皮肤表面的黏附主要依靠羟基的氢键作用力，而当羟基无法向外界吸收水分时，则不能使表皮含水量增大。本公开的发明人发现，在多元醇和神经酰脂的存在下，可以进一步促进透明质酸或其盐的功能，能够使水分深入皮肤表皮中，从而能够有效提高皮肤表皮含水量，从本质上达到深层保湿。
具体地，在本公开的第一方面中，透明质酸或其盐的加入量为0.1％～10％，优选为0.3％～5％，例如0.2％、0.5％、0.8％、1.2％、1.5％、1.8％、2％、3％、4％、5％、6％、7％、8％、9％等。当透明质酸或其盐的含量低于0.1％时，不能提高皮肤表皮含水量；当透明质酸或其盐的加入量大于10％时，会导致稠度过大，不利于皮肤吸收。
神经酰脂
在本公开中，神经酰脂又称糖脂、植物鞘氨醇。本公开的神经酰脂是从假丝酵母菌中筛选高产菌种，通过调整酵母菌生长发酵条件及给予一定营养物质，使菌体生长及代谢过程中，通过利用橄榄油营养物质，转化为神经酰脂，易于渗入皮肤角质层的细胞间隙，维持皮肤水分，起到保湿、润肤及皮肤屏障修复功效。
本公开的神经酰脂由脂肪酸和甘露糖、赤癣糖链接而成。特有的结构让它易于渗入角质细胞间，与原有的外细胞质融合形成液晶层。能够起到保湿和维持皮肤水分的效果。神经酰脂本身具亲油与亲水两种基团，是一个两亲分子，若能将其与透明质酸或其盐组合使用则有助于透明质酸或其盐在皮肤表面进行铺展达到保湿的功效。
本公开的的发明人发现，在神经酰脂的存在下，可以进一步促进多元醇和透明质酸或其盐的保湿功能，能够有效的提高皮肤表皮的含水量。它能够促使保湿剂渗入角质细胞间，通过锁住保湿剂的方式达到保湿效果。具体地，在第一方面中，本公开的神经酰脂的加入量为0.1％～30％，优选为1.5％～25％，例如0.2％、0.5％、0.8％、1％、3％、5％、7％、9％、10％、12％、15％、18％、20％、22％、24％、26％、28％等。在本公开的第一方面中，当神经酰脂的加入量低于0.1％时，不能提高皮肤表皮含水量；当神经酰脂的加入量高于30％时，不能带来更好的效果，还导致成本过高。
在本公开的第一方面中，所述多元醇、透明质酸或其盐以及神经酰脂的质量比为100:(0.5-2.5):(1.5-25)，例如：100:(0.8-2.2):(3-22)、100:(1-2):(5-20)、100:(1.2-1.8):(8-18)、100:(1.4-1.6):(10-16)等，当所述多元醇、透明质酸或其盐以及神经酰脂的质量比为100:(0.5-2.5):(1.5-25)时，有助于透明质酸或其盐在皮肤表面达到最大程度的铺展从而达到提升皮肤含水量的效 果。
D-泛醇
在一些具体的实施方案中，所述保湿组合物还可以包括D-泛醇。D-泛醇(99％)是维生素B5的前体，故又称维生素原B5，它含有不少于99％含量的D-泛醇，它是一种无色至微黄色透明粘稠的液体。
本公开的发明人发现，当使用D-泛醇时，可以进一步改善本申请的提高皮肤表皮含水量的功效。
在另一些优选的实施方案中，以所述保湿组合物的总质量为100％计，所述D-泛醇的加入量为0.5％～30％，优选为4％～25％；例如1％、3％、5％、7％、9％、10％、12％、15％、18％、20％、22％、24％、26％、28％等，本公开通过加入D-泛醇能够进一步提高保湿组合物的保湿效果，当D-泛醇的加入量为0.5％～30％时，能够使高保湿组合物的保湿效果得到最有效的发挥。
进一步地，所述多元醇与所述D-泛醇的质量比可以为100：(4-25)，例如：100:(5-24)、100:(8-22)、100:(10-20)、100:(12-18)、100:(14-16)等。当多元醇与D-泛醇的质量比为100：(4-25)时，能够获得更优异的保湿效果。
本公开的第一方面还提供了一种保湿组合物的制备方法，其包括将所述保湿组合物的各组分混合的步骤；具体地，所述保湿组合物的制备方法包括：在常温下，将保湿组合物按比例称好后进行混合。
本公开的第一方面又提供了一种护肤品，其包括根据本公开所述的保湿组合物，优选地，所述护肤品包括化妆水、膏霜、乳液、啫喱或者精华。具体地，以所述护肤品的总质量为100％计，所述保湿组合物的加入量为0.1-10％，优选为0.5-8％，更优选为1-5％。
<第二方面>
本公开的第二方面提供一种保湿霜，所述膏霜含有本申请第一方面所述的保湿组合物，包含有本公开的保湿组合物的保湿霜可以提高皮肤表皮的含水量，具有优异的保湿效果。具体地，以所述保湿霜的总质量为100％计，所述保湿组合物的加入量为0.1-10％，优选为0.5-8％，更优选为1-5％。
在一些具体的实施方案中，所述保湿霜可以包括保湿剂、增稠剂、油脂、乳化剂以及防腐剂中的一种或两种以上的组合。本公开的保湿霜的配方组成温和，可以使本公开的保湿组合物的功效得到充分发挥。具体而言：
以所述保湿霜的总质量为100％计，所述保湿剂的加入量为0.01-10％。当保湿剂的加入量在0.01-10％时，能够起到保湿作用。为了使保湿剂的功效能够进一步发挥，本公开的保湿剂的加入量可以是1-8％，可以是2-7％，可以是3-6％，可以是4-5％等等。
在本公开中，所述保湿剂包括丁二醇、双丙甘醇、丙二醇、甘油聚丙烯酸酯、海藻糖中的一种或两种以上的组合。
以所述保湿霜的总质量为100％计，所述增稠剂的加入量为0.02-3％。通过添加增稠剂，可以使本公开的保湿霜的稠度合适。作为优选，本公开的增稠剂的加入量可以是0.05-2.5％，可以是0.1-2％，还可以是0.2-1％等。
在本公开中，所述增稠剂包括卡波姆、黄原胶、聚二甲基硅氧烷/乙烯基聚二甲基硅氧烷交联聚合物、山嵛醇、聚丙烯酰胺、丙烯酰二甲基牛磺酸铵/VP共聚物(AVC)、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物中的一种或两种以上的组合。
以所述保湿霜的总质量为100％计，所述油脂的加入量为5-25％，例如所述油脂的加入量可以是8％、10％、12％、15％、18％、20％、12％、25％等。通过在保湿霜中添加油脂，可以减少皮肤表面水分的蒸发，防止皮肤干裂。另外，通过添加油脂，可以在皮肤表面形成疏水性薄膜，防止外部有害物质的侵入。当油脂的含量小于5％时，不能减少皮肤表面水分的蒸发，且不能有效防止有害物质的侵入；当油脂的含量大于25％时，使保湿霜过于油腻，使用感会有所下降。
在本公开中，所述油脂包括异壬酸异壬酯、蜂蜡、肉豆蔻酸异丙酯、聚二甲基硅氧烷、环五聚二甲基硅氧烷、乳木果油、油醇芥酸酯、氢化聚异丁烯、牛油果树果脂、棕榈酸乙基己酯、氢化聚癸烯、环己硅氧烷、C20-24烷基聚二甲基硅氧烷、C13-14异链烷烃、C12-15醇苯甲酸酯、氢化大豆油、植物甾醇类、油橄榄油不皂化物中的一种或两种以上的组合。
在本公开中，以所述保湿霜的总质量为100％计，所述乳化剂的加入量为0.05-5％，例如：可以是 0.1-5％，可以是0.5-3％、可以是1-2％等。本申请的乳化剂用量小于0.05％时，导致乳化不充分使得体系不稳定；乳化剂用量大于5％时，会对产品的稳定性也会造成一定的影响。
在本公开中，所述乳化剂包括鲸蜡硬脂醇、鲸蜡硬脂基葡糖苷、山梨坦倍半油酸酯、异硬脂醇聚醚-20、PEG-10油菜籽甾醇、月桂醇聚醚-7、聚甘油-3甲基葡糖二硬脂酸酯、PEG/PPG-10/1聚二甲基硅氧烷、聚甘油-3二异硬脂酸酯、甘油硬脂酸酯、硬脂醇聚醚-20、鲸蜡醇聚醚-20、山梨坦硬脂酸酯、聚山梨醇酯-60中的一种或两种以上的组合。
另外，本公开的保湿霜中还包含有防腐剂。以所述保湿霜的总质量为100％计，所述防腐剂的加入量为0.5-1.5％。所述防腐剂可以包括馨鲜酮、己二醇、苯氧乙醇、羟苯甲酯、羟苯丙酯、苯甲酸及其盐中的一种或两种以上的组合。
进一步地，本公开还提供一种保湿霜的制备方法，包括将所述化妆品的各组分混合的步骤。
具体而言，所述的保湿霜的制备方法包括以下步骤：
1、将防腐剂预混加热至60-75℃至粉末完全溶解，备用，记作C相；
2、将乳化剂、油脂搅拌并加热到80-85℃，溶解至无颗粒状，记得B相；
3、将保湿剂、保湿组合物以及增稠剂溶于水中后，加热到80-85℃，溶解至无颗粒状，记作A相；
4、在80℃-85℃下，将B相加入A相中均质均匀；
5、将整个体系降温至45℃以下，加入预配好的C相，持续搅拌至均匀，降至室温出料。
<第三方面>
本公开的第三方面提供皮肤修护特护霜，以所述皮肤修护特护霜的总质量为100％计，其包括以下组分：
抗炎修复组分：0.13％-13％；
保湿组分：1.02％-11.2％；以及
屏障修复组分：0.11％-6％；其中
所述保湿组分包括多元醇、透明质酸或其盐和神经酰脂。
本公开的皮肤修护特护霜不仅修护皮肤屏障、控制皮肤炎症以及补水保湿均优异，而且肤感轻薄。
保湿组分
本公开第三方面的保湿组分包括多元醇、透明质酸或其盐和神经酰脂。该保湿组分能够有效提高皮肤表皮含水量，能够从本质上达到深层保湿，当将其应用在本公开的皮肤修护特护霜中时，能够具有优异的保湿效果。
本公开第三方面的保湿组分中的多元醇、透明质酸或其盐和神经酰脂与第一方面中的多元醇、透明质酸或其盐和神经酰脂基本相同。
本公开的发明人发现，当将保湿组分应用于不同护肤品或化妆品中时，为了获得优异的保湿效果，其含量会有所差异。具体而言：
在第三方面中，多元醇的含量过低时，不能起到增加皮肤表面的含水量的效果，多元醇含量过高时，导致其它成分过低，尽管可以起到增加皮肤表面的含水量的效果，但会对产品的使用肤感和成本造成影响。具体地，以所述皮肤修护特护霜的总质量为100％计，所述多元醇的含量为1％-10％，优选2％-5％，例如2％、3％、4％、5％、6％、7％、8％、9％等。
在第三方面中，所述透明质酸或其盐可以是大分子量透明质酸或其盐，也可以是小分子量透明质酸或其盐；具体地，所述透明质酸或其盐的重均分子量为180万道尔顿以下，优选地，大分子量透明质酸或其盐的重均分子量为100万-180万道尔顿，小分子量透明质酸或其盐的重均分子量为5千-1万道尔顿的透明质酸或其盐。
在第三方面中，当透明质酸或其盐的含量过低时，不能提高皮肤表皮含水量；当透明质酸或其盐的含量过高时，会导致稠度过大，不利于皮肤吸收。具体地，以所述皮肤修护特护霜的总质量为100％计，所述透明质酸或其盐的加入量为0.01％-0.3％，优选为0.05％-0.3％，例如0.02％、0.03％、0.04％、0.06％、0.07％、0.08％、0.19％、0.1％、0.11％、0.12％、0.13％、0.14％、0.15％、0.16％、0.17％、0.18％、0.19％、0.2％、0.21％、0.22％、0.23％、0.24％、0.25％、0.26％、0.27％、0.28％、0.29％等。
进一步，在第三方面中，当神经酰脂的加入量过低时，不能提高皮肤表皮含水量；当神经酰脂的加入量过高时，不能带来更好的效果，还导致成本过高。具体地，以所述皮肤修护特护霜的总质量为100％计，所述神经酰脂的加入量为0.01％-1％，优选为0.1％-0.5％，例如0.05％、0.1％、0.2％、0.3％、0.4％、0.5％、0.6％、0.7％、0.8％、0.9％等。
抗炎修护组分
本公开的抗炎修复组分可以包括羟基积雪草苷、多肽，广藿香叶提取物、丹参提取物中的一种或两种以上的组合。
羟基积雪草苷是一种白色的粉末，具有止痒、退红和减缓不适作用，有效减少促炎性细胞因子白介素-1α和白介素-8α释放，减缓炎症反应发生，同时保护细胞免受活性氧自由基的损伤，减少基质金属蛋白酶-1的合成，促进胶原蛋白I的生成。
具体地，以所述皮肤修护特护霜的总质量为100％计，所述羟基积雪草苷的含量为0.01％-1％，例如：0.02％、0.05％、0.08％、0.1％、0.2％、0.3％、0.4％、0.5％、0.6％、0.7％、0.8％、0.9％等。当羟基积雪草苷的含量在0.01％-1％范围内时，其具有良好的消炎退红和减缓不适的效果。
多肽是α-氨基酸以肽键连接在一起而形成的化合物，它也是蛋白质水解的中间产物。由两个氨基酸分子脱水缩合而成的化合物叫做二肽，同理类推还有三肽、四肽、五肽等。通常由三个或三个以上氨基酸分子脱水缩合而成的化合物都可以成为叫多肽。本公开通过使用多肽进一步提高皮肤修护特护霜的抗炎修复功效。
具体地，以所述皮肤修护特护霜的总质量为100％计，所述多肽的含量为0.01％-5％，例如：0.1％、0.3％、0.5％、0.8％、1.2％、1.5％、1.8％、2％、2.5％、3％、3.5％、4％、4.5％等。当多肽的含量在0.01％-5％范围内时，其具有良好的杀菌功效，从而提高抗炎修复功效。
在一些具体的实施方案中，本公开的多肽包括寡肽-1和/或棕榈酰四肽-7。其中，寡肽-1(Oligopeptide-1)为甘氨酸、组氨酸和赖氨酸组成的合成多肽。其能促进受伤的皮肤组织生长，对皮肤溃疡的愈合有很好的疗效，为皮肤的修复提供营养。棕榈酰四肽-7(Palmitoyl Tetrapeptide-7)可以延缓和抑制过量细胞白介素的生成，从而抑制一些不必要不恰当的炎症反应和糖基化损伤。
广藿香叶提取物(Octyldodecanol(and)Pogostemon Cablin Leaf Extract)中含有多种化合物，包括萜类、黄酮类、苯丙素、甾类及生物碱，在抗菌、抗炎、抗过敏、免疫调节等潜在药用价值。
以所述皮肤修护特护霜的总质量为100％计，所述广藿香叶提取物的含量为0.01％-2％，优选0.5％-1％；例如：0.1％、0.3％、0.8％、1.2％、1.5％、1.8％等。当所述广藿香叶提取物的含量为0.01％-2％时，能够起到优异的抗炎的作用。
丹参(SALVIA MILTIORRHIZA)提取物的主要成分是菲醌衍生物。在纤维芽细胞等的培养中，提取物对胶原蛋白的增殖有很好的促进作用，因此可增强皮肤真皮层的新陈代谢，并且还具有抗菌、抗炎等功效。
具体地，以所述皮肤修护特护霜的总质量为100％计，所述丹参提取物的含量为0.1％-5％，优选0.2％-2％，例如：0.3％、0.5％、0.8％、1.2％、1.5％、1.8％、2％、2.5％、3％、3.5％、4％、4.5％等。当丹参提取物的含量在0.1％-5％范围内时，其具有良好的杀菌抗炎功效，并且还具有活肤修复的作用。
当使用羟基积雪草苷、多肽，广藿香叶提取物和丹参提取物的组合作为抗炎修复组分时，其具有协同作用，能够使其中的各个成分的功效得到最有效的发挥。
屏障修复组分
本公开的屏障修复组分可以包括神经酰胺和/或植物甾醇低芥酸菜籽油甘油酯类。
其中，神经酰胺是构成皮肤角质层脂质的主要成分，能帮助修复皮肤屏障可以使皮肤柔软富有光泽。神经酰胺不仅能够抵挡外界的刺激，还能够使角质层增厚，提升整个皮肤的耐受力，避免敏感发生并且修复红血丝，是一种优异的屏障修复组分。
优选地，以所述皮肤修护特护霜的总质量为100％计，所述神经酰胺的含量为0.01％-1％，优选0.3-0.6％，例如：0.02％、0.05％、0.08％、0.1％、0.2％、0.3％、0.4％、0.5％、0.6％、0.7％、0.8％、0.9％等。当神经酰胺的加入量为0.01％-1％时，其能够有效抵挡外界的刺激，并且能够使角质层增厚，提 升整个皮肤的耐受力，避免敏感发生并且修复红血丝。
植物甾醇低芥酸菜籽油甘油酯类(Phytosteryl Canola Glycerides，AAK AB)适用于敏感肌，用于改善干性皮肤的保水能力，保护皮肤免受环境危害。
优选地，以所述皮肤修护特护霜的总质量为100％计，所述植物甾醇低芥酸菜籽油甘油酯类的含量为0.1％-5％，优选0.5％-2％，例如：0.3％、0.5％、0.8％、1.2％、1.5％、1.8％、2％、2.5％、3％、3.5％、4％、4.5％等。所述植物甾醇低芥酸菜籽油甘油酯类的含量为0.1％-5％时，能够更好地与神经酰胺产生协同作用，从而修护皮肤屏障。
其它组分
本公开的所述皮肤修护特护霜还可以包括乳化剂、润肤油脂、增稠剂以及防腐剂中的一种或两种以上的组合。优选地，所述乳化剂的含量为0.1-1％；所述润肤油脂的含量为1％-10％，所述增稠剂的含量为0.3％-1％，所述防腐剂的含量为0.1％-1％。
对于乳化剂，在本公开中，以所述皮肤修护特护霜的总质量为100％计，所述乳化剂的加入量为0.1-1％，例如：0.2％、0.3％、0.4％、0.5％、0.6％、0.7％、0.8％、0.9％等。本申请的乳化剂用量过低时，导致乳化不充分使得体系不稳定；乳化剂用量过高时，会对产品的稳定性也会造成一定的影响。
对于乳化剂的种类，本公开不作特别限定，可以是本领域常用的一些乳化剂。具体地，在本公开中，所述乳化剂包括氢化卵磷脂、PEG-20甲基葡糖倍半硬脂酸酯和甲基葡糖倍半硬脂酸酯等中的一种或两种以上的组合。
对于增稠剂，在本公开中，以所述皮肤修护特护霜的总质量为100％计，所述增稠剂的含量为0.3％-1％，优选0.5-0.8％，例如：0.4％、0.5％、0.6％、0.7％、0.8％、0.9％等。通过添加增稠剂，可以使本公开的皮肤修护特护霜的稠度合适。
对于增稠剂的种类，本公开不作特别限定，可以是本领域常用的一些增稠剂。具体地，在本公开中，所述增稠剂包括卡波姆、丙烯酰二甲基牛磺酸铵/VP共聚物、丙烯酸(酯)类/C10-30烷醇丙烯酸酯交联聚合物中的一或两种以上的组合。
对于润肤油脂，在本公开中，以所述皮肤修护特护霜的总质量为100％计，所述润肤油脂的含量为1％-10％，优选2％-5％，例如：2％、3％、4％、5％、6％、7％、8％、9％等。在皮肤修护特护霜中添加润肤油脂，可以减少皮肤表面水分的蒸发，防止皮肤干裂。另外，通过添加润肤油脂，可以在皮肤表面形成疏水性薄膜，防止外部有害物质的侵入。当油脂的含量过低时，不能减少皮肤表面水分的蒸发，且不能有效防止有害物质的侵入；当润肤油脂的含量过高时，使皮肤修护特护霜过于油腻，使用感会有所下降。
对于润肤油剂的种类，本公开不作特别限定，可以是本领域常用的一些增稠剂。具体地，在本公开中，所述润肤油脂包括聚二甲基硅氧烷、乳木果油、辛酸/癸酸甘油三酯、聚二甲基硅氧烷醇以及角鲨烷中的一种或两种以上的组合。
另外，本公开的皮肤修护特护霜中还可以包含pH调节剂、防腐剂等。对于pH调节剂、防腐剂的含量，本公开不作特别限定，可以根据需要进行添加。具体地，对于pH调节剂的添加量，本公开不作特别限定，通过添加pH调节剂，使本公开的皮肤修护特护霜的pH为中性即可。而对于所述防腐剂的含量，一般不可超过化妆品行业规定，具体地，所述防腐剂的含量可以为0.1％-1％，优选0.5％-0.8％。
具体地，在本公开中，所述pH调节剂可以是本领域常用的pH调节剂，例如：氨甲基丙醇等。
进一步地，本公开的第三方面还提供一种皮肤修护特护霜的制备方法，其包括将皮肤修护特护霜的各组分混合的步骤。
具体地，本公开的皮肤修护特护霜的制备方法包括以下步骤：
步骤1)将保湿组分、任选存在地增稠剂及任选存在地去离子水混合记作A相，屏障修复组分、任选存在地润肤油脂及任选存在地乳化剂混合记作B相。
步骤2)将A、B两相混合均匀后分别加热至80-85℃，再将B相添加至A相中，均质均匀。
步骤3)将整个体系降至45℃，将抗炎修复组分、任选存在地防腐剂、任选存在地pH调节剂加入，搅拌均匀至常温后出料。
<第四方面>
本公开的第四方面提供一种粉底组合物，以所述粉底组合物的总质量为100％计，其包括以下组成：
遮瑕组分：28.4％-70.8％，优选为30％-65％；
修护组分：0.91％-3.6％，优选为1％-3％；
保湿组分：3％-10％，优选为4％-9％；
舒缓组分：0.3％-6％，优选为1-3％。
本公开的粉底组合物对皮肤的修护作用强，保湿效果优异，且仍然具有优异的遮瑕能力。
遮瑕组分
本公开的粉底组合物中包含有遮瑕组分。本公开的粉底组合物由于遮瑕组分的存在，从而在上底妆的时候可以发挥均匀肤色，调整肌肤颜色的作用，能够让肌肤看起来更自然均匀。并且本公开的粉底组合物的遮瑕能力强，特别是对于细纹和色斑具有优异的遮瑕能力。
在本公开中，以所述粉底组合物的总质量为100％计，遮瑕组分的含量为28.4％-70.8％，优选30-65％，更优选为30％-60％；例如：所述遮瑕组分的含量为25％、28％、32％、35％、38％、40％、42％、45％、48％、50％、52％、55％、58％、60％、62％、65％、68％、70％等。在本公开中，如果遮瑕组分的含量低于28.4％，则粉底组合物基本不具备遮盖力，只有轻微的提亮效果；如果遮瑕组分的含量高于70.8％，则可能会出现浮粉现象。
在一些具体的实施方案中，本公开的所述遮瑕组分包括钛白粉；本公开通过使用钛白粉使得本公开的粉底组合物具有一定的遮盖作用，从而具有一定的遮瑕功能。
优选地，所述钛白粉的平均粒径为50nm-200nm。本公开优选使用不同平均粒径的钛白粉，例如：平均粒径为50-99nm的钛白粉、平均粒径为100-149nm的钛白粉、平均粒径为150-200的钛白粉等。在粉体分散过程中普通的均质分散无法将粉体分散至原始粒径，因此钛白粉在分散后，会大于原始粒径。其中，较大粒径的钛白粉具有强的遮盖力，中间粒径钛白粉具有一定的遮盖能力，小粒径的钛白粉遮盖力弱，但贴服性好。
进一步，在本公开中，以所述粉底组合物的总质量为100％计，所述钛白粉的含量可以为12％-24％，优选12％-18％；例如：所述钛白粉的含量为13％、14％、15％、16％、17％、18％、19％、20％、21％、22％、23％、24％等。当钛白粉的含量为12％-24％时，遮瑕效果比较优异。
进一步，在本公开中，所述遮瑕组分还包括颜料、分散剂、润肤油脂、弹性体、硅石以及成膜剂中的一种或两种以上的组合；以所述粉底组合物的总质量为100％计，所述颜料的含量为0.1％-1.5％，所述分散剂的含量为0.3％-1.5％，所述润肤油脂的含量为10-28.8％，所述弹性体的含量为2％-5％，所述成膜剂的含量为2％-5％；所述硅石的含量为2％-5％。
上妆是否贴服是评价底妆优劣的一个标准，分散剂的添加有助于粉组分的分散，本公开通过使用分散剂能更好的帮助上妆时的粉体贴服。以所述粉底组合物的总质量为100％计，所述分散剂的含量为0.3-1.5％，例如：所述分散剂的含量为0.4％、0.5％、0.6％、0.7％、0.8％、0.9％、1％、1.1％、1.2％、1.3％、1.4％等。当分散剂的含量为0.3-1.5％时，肤感比较轻盈，且粉体分散均匀，贴服性好。
具体地，所述分散剂包括聚羟基硬脂酸、聚甘油-3二异硬脂酸酯中的一种或两种。
在本公开中，弹性体的添加可以起到隐形毛孔的效果。以所述粉底组合物的总质量为100％计，所述弹性体的含量为2％-5％，例如：所述弹性体的含量为2.2％、2.5％、2.8％、3％、3.2％、3.5％、3.8％、4％、4.2％、4.5％、4.8％等。
具体地，所述弹性体包括聚二甲基硅氧烷/乙烯基聚二甲基硅氧烷交联聚合物、聚硅氧烷-11和HDI/三羟基己基内酯交联聚合物中的一种或两种以上的组合。
在本公开中，上妆后的妆容持久度也是一个重点关注区，成膜剂的添加则有助于上妆后的持妆效果。以所述粉底组合物的总质量为100％计，所述成膜剂的含量为2％-5％，例如：所述成膜剂的含量为2.2％、2.5％、2.8％、3％、3.2％、3.5％、3.8％、4％、4.2％、4.5％、4.8％等。
具体地，所述成膜剂包括三甲基硅烷氧基硅酸酯、硬脂酸柠檬酸酯、三(辛基十二烷醇)柠檬酸 酯中的一种或两种以上的组合。
在本公开中，通过使用颜料来调整粉底组合物的颜色，以使得该粉底组合物更接近肤色。以所述粉底组合物的总质量为100％计，所述颜料的含量为0.1％-1.5％，例如：所述颜料的含量为0.2％、0.3％、0.4％、0.5％、0.6％、0.7％、0.8％、0.9％、1％、1.1％、1.2％、1.3％、1.4％等。
具体地，所述颜料包括铁黄、铁红、铁黑中的一种或两种以上的组合。
进一步，本公开通过使用润肤油脂来改善粉液组合物的肤感，并能起到保湿的作用。以所述粉底组合物的总质量为100％计，所述润肤油脂的含量为10-28.8％，例如：所述润肤油脂的含量为12％、15％、18％、20％、22％、25％、28％等。
具体地，在本公开中，所述润肤油脂包括碳酸二辛脂、异十二烷、聚二甲基硅氧烷、苯基聚三甲基硅氧烷、氢化聚异丁烯、C12-15醇苯甲酸酯、甘油三(乙基己酸)酯、碳酸二辛酯、二异硬脂醇苹果酸酯中的一种或两种以上的组合。
进一步，本公开遮瑕组分还包含有硅石，通过使用硅石有助于增加滑感和去除油感，使得上妆时更易推开。在本公开中，所述硅石的含量为2-5％，例如：所述硅石的含量为2.2％、2.5％、2.8％、3％、3.2％、3.5％、3.8％、4％、4.2％、4.5％、4.8％等。
修护组分
本公开通过使用修复组分，以使得本公开的粉底组合物在具有遮盖力的同时，还具有一定的修护作用。具体地，在本公开中，以所述粉底组合物的总质量为100％计，所述修护组分的含量为0.91％-3.6％，优选为1％-3％；例如：所述修护组分的含量为1％、1.2％、1.5％、1.8％、2％、2.2％、2.5％、2.8％、3％、3.2％、3.5％等。当本公开的修护组分低于0.91％时，使用者感受不到修护效果；当修护组分的含量高于3.6％时，则会存在肤感厚重、闷痘、刺激等不良反应。
在本公开中，所述修护组分可以包括精油、神经酰胺、植物甾醇低芥酸菜油甘油酯中的一种或两种以上的组合；其中，以所述粉底组合物的总质量为100％计，所述精油的含量可以为0.4％-1.4％，所述神经酰胺的含量可以为0.01％-0.5％，所述植物甾醇低芥酸菜油甘油酯的含量可以为0.5-1.7％；优选地，所述精油包括薰衣草精油、茶树精油以及甜橙精油中的一种或两种以上的组合。
在本公开中，精油可以改善油性皮肤，祛除细胞角质，使皮肤维持弹性，有效的改善循环性障碍。此外精油可以促进睡眠，预防皱纹的产生，消除黑眼圈，帮助淡化色斑。具体地，在本公开中，薰衣草油与茶树精油均有较强的抑菌抗炎效果，且对受损的皮肤有修复效果。甜橙精油除了具有抑菌效果外还具有抗氧化的作用，可用于干性和衰老性皮肤的护理。
进一步，在本公开中，以所述粉底组合物的总质量为100％计，所述精油的含量为0.4％-1.4％；例如：所述精油的含量为0.45％、0.5％、0.6％、0.7％、0.8％、0.9％、1％、1.1％、1.2％、1.3％、1.35％等。当精油含量为0.4％-1.4％时，可以起到控油、促进血液循环的作用。且长期使用下可以达到护肤的效果。
本公开的发明人发现，薰衣草精油、茶树精油以及甜橙精油的组合具有协同作用，能够进一步起到修护作用。其中，以所述粉底组合物的总质量为100％计，薰衣草精油的含量为0.3％-1％，例如：所述熏衣草精油的含量为0.4％、0.5％、0.6％、0.7％、0.8％、0.9％等；茶树精油含量的含量为0.05％-0.2％；例如：所述茶树精油的含量为0.06％、0.07％、0.08％、0.09％、0.1％、0.11％、0.12％、0.13％、0.14％、0.15％、0.16％、0.17％、0.18％等；所述甜橙精油的含量为0.05％-0.2％；所述甜橙精油的含量为0.06％、0.07％、0.08％、0.09％、0.1％、0.11％、0.12％、0.13％、0.14％、0.15％、0.16％、0.17％、0.18％等。
进一步地，神经酰胺是构成皮肤角质层脂质的主要成分，本公开通过适当添加一些神经酰胺来帮助修复皮肤屏障，从而使得皮肤柔软且富有光泽。神经酰胺不仅能够抵挡外界的刺激，还能够使角质层增厚，提升整个皮肤的耐受力，避免敏感发生并且修复红血丝，是一种优异的屏障修复组分。
进一步，在本公开中，以所述粉底组合物的总质量为100％计，所述神经酰胺的含量为0.01％-0.5％；例如：所述神经酰胺的含量为0.03％、0.05％、0.08％、0.1％、0.12％、0.15％、0.18％、0.2％、0.25％、0.3％、0.35％、0.4％、0.45％等。当神经酰胺的含量为0.01％-0.5％时，有助于修复皮肤屏障，且成本不会过高，长期使用效果更好。
另外，植物甾醇低芥酸菜籽油甘油酯类是低芥酸油菜籽的甘油酯与植物固醇的合成品，同样具有形成皮脂膜，促进皮肤分泌神经酰胺的作用。
作为优选，在本公开中，所述植物甾醇低芥酸菜油甘油酯的含量为0.5％-1.7％；例如：所述植物甾醇低芥酸菜油甘油酯的含量为0.6％、0.7％、0.8％、0.9％、1％、1.1％、1.2％、1.3％、1.4％、1.5％、1.6％等。当植物甾醇低芥酸菜油甘油酯的含量为0.5％-1.7％时，不会感到肤感厚重，且具有优异的修护作用。
保湿组分
本公开通过适当添加一些保湿组分，以使得本公开的粉底组合物还具有保湿功效。在本公开中，以所述粉底组合物的总质量为100％计，所述保湿组分的含量为3％-10％，优选为4％-9％，例如：所述保湿组分的含量为4％、4.5％、5％、5.5％、6％、6.5％、7％、7.5％、8％、8.5％等。如果本公开的保湿组分含量低于3％，则上妆后的润感会降低，上妆后易出现干燥起皮现象；如果本公开的保湿组分含量高于10％，则上妆后不会快速干爽。
具体地，本公开的保湿组分包括多元醇、透明质酸或其盐和神经酰脂。该保湿组分能够有效提高皮肤表皮含水量，能够从本质上达到深层保湿，当将其应用在本公开的粉底组合物中时，能够具有优异的保湿效果。
本公开第四方面的保湿组分中的多元醇、透明质酸或其盐和神经酰脂与第一方面中的多元醇、透明质酸或其盐和神经酰脂相同。
本公开的发明人发现，当将保湿组分应用于不同护肤品或化妆品中时，为了获得优异的保湿效果，其含量会有所差异。具体而言：
在第四方面中，多元醇的含量过低时，不能起到增加皮肤表面的含水量的效果，多元醇含量过高时，导致其它成分过低，尽管可以起到增加皮肤表面的含水量的效果，但会对产品的使用肤感和成本造成影响。具体地，以所述粉底组合物的总质量为100％计，多元醇含量为2.88％-8.8％，例如：所述多元醇的含量为3％、3.5％、4％、4.5％、5％、5.5％、6％、6.5％、7％、7.5％、8.5％等。
在本公开的第四方面中，在本公开的第四方面中，所述透明质酸或其盐的重均分子量可以为180万道尔顿以下，优选为100万-180万道尔顿。
在本公开的第四方面中，当透明质酸或其盐的含量过低时，不能提高皮肤表皮含水量；当透明质酸或其盐的含量过高时，会导致稠度过大，不利于皮肤吸收。具体地，以所述粉底组合物的总质量为100％计，所述透明质酸或其盐的加入量为0.02％-0.2％，例如：所述透明质酸或其盐的含量为0.04％、0.06％、0.08％、0.1％、0.12％、0.14％、0.16％、0.18％等。
在本公开的第四方面中，当神经酰脂的加入量过低时，不能提高皮肤表皮含水量；当神经酰脂的加入量过高时，不能带来更好的效果，还导致成本过高。具体地，以所述粉底组合物的总质量为100％计，本公开第四方面的神经酰脂的加入量为0.1％-1％，例如：所述神经酰脂的含量为0.15％、0.2％、0.25％、0.3％、0.35％、0.4％、0.45％、0.5％、0.55％、0.6％、0.65％、0.7％、0.75％、0.8％、0.85％、0.9％、0.95％等。
舒缓组分
本公开通过适当添加一些舒缓组分，以使得本公开的粉底组合物还具有舒缓功效。在本公开中，以所述粉底组合物的总质量为100％计，所述舒缓组分的含量为0.3％-6％，优选为1％-3％，例如：所述舒缓组分的含量为0.5％、1％、1.5％、2％、2.5％、3％、3.5％、4％、4.5％、5％、5.5％等。在本公开中，如果舒缓组分的含量低于0.3％，则效果不明显，如果舒缓组分的含量超过6％，则成本过高。
在一些具体的实施方案中，所述舒缓组分包括扭刺仙人掌提取物、黄芩提取物、羟基积雪草苷、广藿香叶提取物中的一种或两种以上的组合中的一种或两种以上的组合。
优选地，所述舒缓组分包括扭刺仙人掌提取物、黄芩提取物、羟基积雪草苷、广藿香叶提取物中的一种或两种以上的组合中的两种以上的组合。当选用两种以上的舒缓组分时，其舒缓效果会更加优异。
在一些更优选的实施方案中，考虑到舒缓效果能够最有效的发挥，本申请的所述舒缓组分包括扭刺仙人掌提取物、黄芩提取物以及广藿香叶提取物的组合；优选地，以所述粉底组合物的总质量为100％计，所述扭刺仙人掌提取物的含量为0.1％-3％；具体地，所述扭刺仙人掌提取物的含量为0.3％、0.5％、0.8％、1％、1.2％、1.5％、1.8％、2％、2.2％、2.5％、2.8％等；所述黄芩提取物的含量为0.1％-1.8％；具体地，所述黄芩提取物的含量为0.2％、0.5％、0.8％、1％、1.2％、1.5％、1.8％等；所述广藿香叶提取物的含量为0.1％-1.2％；具体地，所述广藿香叶提取物的含量为0.2％、0.5％、0.8％、1％、1.2％等。
其它组分
本公开的所述粉底组合物还可以包括乳化剂、增稠剂、无机盐、防腐剂、溶剂中的一种或两种以上的组合。
优选地，以所述粉底组合物的总质量为100％计，所述乳化剂的含量为3％-7％，优选为4％-6％；所述增稠剂的含量为0％-0.4％，优选为0.1％-0.2％；所述无机盐的含量为0.5％-1.2％，优选为0.7％-1％；所述防腐剂的含量为0.5％-1.0％，优选为0.6％-0.8％；一般余量为溶剂，具体地，所述溶剂的含量可以为0％-63.39％，优选为12％-58.6％。
具体地，在本公开中，所述乳化剂可以包括山梨坦异硬脂酸酯、PEG/PPG-20/14聚二甲基硅氧烷、PEG-10聚二甲基硅氧烷、聚甘油-3聚蓖麻醇酸酯中的一种或两种以上的组合；所述增稠剂可以包括黄原胶和/或丙烯酰二甲基牛磺酸铵/VP共聚物。所述无机盐可以包括硫酸镁等护肤品中常用的无机盐。所述防腐剂可以包括苯氧乙醇、羟苯甲酯、乙基己基甘油中的一种或两种以上的组合。
制备方法
本公开的第四方面还提供一种根据本公开第四方面的所述的粉底组合物的制备方法，其包括将所述粉底组合物的各组分混合的步骤。
具体地，所述制备方法包括以下步骤：
将部分遮瑕剂和乳化剂过胶体磨研磨至分散均匀后，得到预混物；
将剩余的遮瑕剂和部分修护组分与上述预混物混合，得到混合前体；
将增稠剂、无机盐、舒缓组分溶于溶剂，并混合均匀后，添加至上述混合前体中，得到再混物；
降温，将剩余的修护组分与防腐剂加入再混物中，得到粉底组合物。
进一步，所述制备方法包括以下步骤：
将部分遮瑕剂和乳化剂过胶体磨研磨1-5次至分散均匀后，得到预混物；
将剩余的遮瑕剂和部分修护组分与上述预混物混合，加热至75-85℃，均质均匀后降至55-65℃，得到混合前体；
将增稠剂、无机盐、舒缓组分溶于溶剂，并混合均匀后，添加至上述混合前体中，得到再混物，持续降温；
降温至40℃以下，将剩余的修护组分与防腐剂加入再混物中，得到粉底组合物。
实施例
下面将结合实施例对本公开的实施方案进行详细描述，但是本领域技术人员将会理解，下列实施例仅用于说明本公开，而不应视为限定本公开的范围。实施例中未注明具体条件者，按照常规条件或制造商建议的条件进行。所用材料或仪器除非特别说明，均为可以使用通过市购获得的常规产品。
实施例中：神经酰脂：购自广东现代汉方科技有限公司，其主要性状如下表A所示：
表A
Figure PCTCN2022088197-appb-000001
透明质酸钠：山东福瑞达医药集团有限公司，重均分子量100万-180万道尔顿。
羟基积雪草苷的生产厂家为法国赛比克公司；
广藿香叶提取物的生产厂家为美国亚仕兰公司；
扭刺仙人掌提取物：北京华夏众芳生物科技有限公司；
黄芩提取物：荷兰帝斯曼公司；
丹参提取物的生产厂家为东方淼森生物科技有限公司；
植物甾醇低芥酸菜籽油甘油酯类的生产厂家为AKK北欧油脂集团；
黄芩提取物的生产厂家为荷兰帝斯曼公司；
扭刺仙人掌提取物的生产厂家北京华夏众芳生物科技有限公司；
大分子量透明质酸钠：100万-180万道尔顿，生产厂家：华熙生物科技股份有限公司；
小分子量透明质酸钠：5千-1万道尔顿，生产厂家：华熙生物科技股份有限公司。
钛白粉按平均粒径的不同分为三种，具体为平均粒径为50nm的钛白粉，平均粒径为100nm的钛白粉以及平均粒径为150nm的钛白粉。
实施例一
对比例1.1-1.6
按下表1.1所示的质量百分比，常温下混合均匀，获取对比例1.1-1.6的保湿组合物的水溶液。
表1.1
Figure PCTCN2022088197-appb-000002
实施例1.1-1.5
按下表1.2所示的质量百分比，常温下混合均匀，获取实施例1.1-1.5的保湿组合物的水溶液。
表1.2
实施例 实施例1.1(％) 实施例1.2(％) 实施例1.3(％) 实施例1.4(％) 实施例1.5(％)
样品编号 样品a 样品b 样品c 样品d 样品e
甘油 2 2 2 2 2
透明质酸钠 0.05 0.05 0.01 0.05 0.1
神经酰酯 0.1 0.2 0.3 0.3 0.3
水 添加至100 添加至100 添加至100 添加至100 添加至100
实施例1.6-1.8
按下表1.3所示的质量百分比，常温下混合均匀，获取实施例1.6-1.8的保湿组合物的水溶液。
表1.3
实施例 实施例1.6(％) 实施例1.7(％) 实施例1.8(％)
样品编号 样品f 样品g 样品h
甘油 2 2 2
透明质酸钠 0.05 0.05 0.05
神经酰酯 0.5 0.05 0.1
D-泛醇 0 0.5 0.1
水 添加至100 添加至100 添加至100
性能测试
1.1、对比例1.1的皮肤含水率测试
挑选20-30岁的女性受试者进行保湿测试。选取将对比例1.1的样品A作为测试样品，在志愿者前臂内侧区域选取两个区域，每个区域大小为3.0cm×3.0cm，其中一个区域的样品用量为(2.0±0.1)mg/cm 2(即0.0171g～0.0189g)作为测试区域，另一个区域不涂抹产品。分别测量测试区域初始及涂抹产品后2小时和4小时的角质层含水量作为样品的数值，并测量不涂抹产品的区域在初始、2小时和4小时后的角质层含水量作为空白对照，结果如表1.4所示。
表1.4
Figure PCTCN2022088197-appb-000003
1.2、对比例1.2-1.3的皮肤含水率测试
挑选20-30岁的女性受试者进行保湿测试。选取将对比例1.2-1.3的样品B-C作为测试样品，在志愿者前臂内侧区域选取三个区域，每个区域大小为3.0cm×3.0cm，其中两个区域分别使用样品B和样品C，样品用量为(2.0±0.1)mg/cm 2(即0.0171g～0.0189g)作为测试区域，另一个区域不涂抹产品。分别测量测试区域初始及涂抹产品后2小时和4小时的角质层含水量作为样品的数值，并测量不涂抹产品的区域在初始、2小时和4小时后的角质层含水量作为空白对照，其中，同时测试样品B和样品C，并选用同一块区域作为空白对照，结果如表1.5所示。
表1.5
Figure PCTCN2022088197-appb-000004
1.3、对比例1.4-1.6的皮肤含水率测试
挑选20-30岁的女性受试者进行保湿测试。选取将对比例1.4-1.6的样品D-F作为测试样品，在志愿者前臂内侧区域选取两个区域，每个区域大小为3.0cm×3.0cm，其中一个区域的样品用量为(2.0±0.1)mg/cm 2(即0.0171g～0.0189g)作为测试区域，另一个区域不涂抹产品。分别测量测试区域初始及涂抹产品后2小时和4小时的角质层含水量作为样品的数值，并测量不涂抹产品的区域在初始、2小时和4小时后的角质层含水量作为空白对照，结果如表1.6所示。
表1.6
Figure PCTCN2022088197-appb-000005
根据表1.4-1.6的结果可以看出，样品A-E均基本无保湿效果。可以看出，单纯的透明质酸钠水溶液及D-泛醇水溶液不能使表皮的水分含量上升。甘油分别和透明质酸钠、神经酰脂与D-泛醇搭配后所得的保湿组合物的水溶液也不会起到明显的增效作用。
1.4、实施例1.1-1.2的皮肤含水率测试
挑选20-30岁的女性受试者进行保湿测试。选取将实施例1.1-1.2的样品a-b，作为测试样品，在志愿者前臂内侧区域选取三个区域，每个区域大小为3.0cm×3.0cm，其中两个区域分别使用样品a和样品b，样品用量为(2.0±0.1)mg/cm 2(即0.0171g～0.0189g)作为测试区域，另一个区域不涂抹产品。分别量测试区域初始及涂抹产品后2小时和4小时的角质层含水量作为样品的数值，并测量不涂抹产品的区域在初始、2小时和4小时后的角质层含水量作为空白对照，结果如表1.7所示。
表1.7
Figure PCTCN2022088197-appb-000006
1.5、实施例1.3-1.5的皮肤含水率测试
挑选20-30岁的女性受试者进行保湿测试。选取将实施例1.3-1.5的样品c-e，作为测试样品，在志愿者前臂内侧区域选取四个区域，每个区域大小为3.0cm×3.0cm，其中三个区域分别使用样品c-e，样品用量为(2.0±0.1)mg/cm 2(即0.0171g～0.0189g)作为测试区域，另一个区域不涂抹产品。分别量测试区域初始及涂抹产品后2小时和4小时的角质层含水量作为样品的数值，并测量不涂抹产品的区域在初始、2小时和4小时后的角质层含水量作为空白对照，结果如表1.8所示。
表1.8
Figure PCTCN2022088197-appb-000007
根据表1.7-表1.8的结果可以看出，样品a-e均有明显的保湿效果。这五个样品中，神经酰酯的含量逐渐增加而透明质酸钠的含量不变时，在神经酰酯的添加量为0.1％以上时，保湿效果并无十分明显的变化。样神经酰脂的含量不变而透明质酸钠的含量逐渐增加时，保湿效果逐渐增强。当透明质酸钠含 量到达0.05％以上时，保湿效果的增幅减缓。
结合表1.7-1.8的实验结果可以看出，神经酰脂的参与可以明显的提升透明质酸钠的保湿效果。神经酰脂易于渗入角质细胞间形成液晶层，当它与透明质酸钠结合时，有助于透明质酸钠一同渗入角质细胞间，形成保湿屏障。
1.6、实施例1.6-1.7的皮肤含水率测试
挑选20-30岁的女性受试者进行保湿测试。选取将实施例1.6-1.7的样品f-g作为测试样品，在志愿者前臂内侧区域选取三个区域，每个区域大小为3.0cm×3.0cm，其中两个区域分别使用样品f和样品g，样品用量为(2.0±0.1)mg/cm 2(即0.0171g～0.0189g)作为测试区域，另一个区域不涂抹产品。分别测量测试区域初始及涂抹产品后2小时和4小时的角质层含水量作为样品的数值，并测量不涂抹产品的区域在初始、2小时和4小时后的角质层含水量作为空白对照，其中，同时测试样品B和样品C，并选用同一块区域作为空白对照，结果如表1.9所示。
表1.9
Figure PCTCN2022088197-appb-000008
1.7、实施例1.8的皮肤含水率测试
挑选20-30岁的女性受试者进行保湿测试。选取将实施例1.8的样品h，作为测试样品，在志愿者前臂内侧区域选取两个区域，每个区域大小为3.0cm×3.0cm，其中一个区域的样品用量为(2.0±0.1)mg/cm 2(即0.0171g～0.0189g)作为测试区域，另一个区域不涂抹产品。分别测量测试区域初始及涂抹产品后2小时和4小时的角质层含水量作为样品的数值，并测量不涂抹产品的区域在初始、2小时和4小时后的角质层含水量作为空白对照，结果如表1.10所示。
表1.10
Figure PCTCN2022088197-appb-000009
根据表1.9-1.10的结果可以看出，样品f-h的保湿效果优异，且样品g-h的保湿效果相比实施例1.1-1.5更优异。
实施例二
实施例2.1-2.3
按下表2.1所示的配方制备保湿霜，具体制备步骤如下：
1)精确称量A、B、C相各组分。将C相预混，加热至粉末完全溶解，备用。
2)将A、B相分别搅拌加热至80℃-85℃，溶解至无颗粒状。在80℃-85℃下，将B相加入A相中均质均匀。
3)将整个体系降温至45℃下，加入预配好的C相，持续搅拌至均匀，降至室温出料。
表2.1保湿霜配方
Figure PCTCN2022088197-appb-000010
性能测试
2.1、实施例2.1-2.2和应用对照组的皮肤含水率测试
挑选20-30岁的女性受试者进行保湿测试。选取应用实施例2.1-2.2的样品F1-1、F1-2和应用对照组作为测试样品。在选取志愿者前臂内侧区域选取四个区域，每个区域大小为3.0cm×3.0cm，，其中三个区域分别使用样品F1-1、F1-2和应用对照组，样品用量为(2.0±0.1)mg/cm 2(即0.0171g～0.0189g)作为测试区域，另一个区域不涂抹产品。分别测量测试区域初始及涂抹产品后2小时和4小时的角质层含水量作为样品的数值，并将不涂抹产品的区域在初始、2小时和4小时后的角质层含水量作为空白对照，结果如表2.2所示。
表2.2
Figure PCTCN2022088197-appb-000011
2.2、实施例2.3的皮肤含水率测试
挑选20-30岁的女性受试者进行保湿测试。选取应用实施例2.3的样品F1-3作为测试样品。在志愿者前臂内侧区域选取两个区域，每个区域大小为3.0cm×3.0cm，其中一个区域使用样品F1-3，用量为(2.0±0.1)mg/cm 2(即0.0171g～0.0189g)作为测试区域，另一个区域不涂抹产品。分别测量测试区域初始及涂抹产品后2小时和4小时的角质层含水量作为样品的数值，并将不涂抹产品的区域在初始、2小时和4小时后的角质层含水量作为空白对照，结果如表2.3所示。
表2.3
Figure PCTCN2022088197-appb-000012
根据表2.2-2.3的实验结果可以看出，与空白组和应用对照组比较，应用了该组合的样品F1-1、样品F1-2及样品F1-3的保湿效果显著。
实施例三
实施例3.1-3.7
准确称量A、B两相。
将A、B两相分别混合均匀后，升温至80-85℃，将B相添加至A相中，均质均匀后，降温。
待整个体系持续搅拌降温至45℃以下，依次加入C相和预混好的D相，搅拌均匀后出料。
按下表3.1-3.2的所示的质量百分含量，按照上述方法制备得到皮肤修护特护霜。
表3.1
Figure PCTCN2022088197-appb-000013
表3.2
Figure PCTCN2022088197-appb-000014
对比例3.1-3.5
准确称量A、B两相。
将A、B两相分别混合均匀后，升温至80-85℃，将B相添加至A相中，均质均匀后，降温待整个体系持续搅拌降温至45℃以下，依次加入C相和预混好的D相，搅拌均匀后出料。
按下表3.3的所示的质量百分含量，按照上述方法制备得到皮肤修护特护霜。
表3.3
Figure PCTCN2022088197-appb-000015
性能测试
3.1、舒缓修复效果
以实施例3.1-3.7和对比例3.1-3.4作为测试样品，每组挑选20位20-30岁出现过过敏现象的女性受试者进行测试，每天早晚面部使用，使用量为(2.0±0.1)mg/cm 2(即0.0171g～0.0189g)。以调查问卷形式分别测试受试者使用7天后的皮肤状态，舒缓修复效果以10分计，0分代表没效果，10分代表皮肤干燥或出痘症状明显改善，结果如表3.4和表3.5所示。
表3.4
受试者编号 实施例1 实施例2 实施例3 实施例4 实施例5 实施例6 实施例7
1 6 6 4 6 7 8 8
2 5 5 4 6 7 6 7
3 5 7 5 7 7 7 7
4 5 5 3 6 6 6 7
5 6 6 6 5 8 6 6
6 4 4 2 5 7 7 5
7 5 5 4 6 5 8 6
8 4 3 4 5 6 7 6
9 4 3 2 2 5 8 7
10 5 6 5 6 6 7 8
11 4 4 3 5 6 8 7
12 4 6 6 6 7 8 7
13 5 3 4 4 6 7 7
14 3 5 4 6 6 7 6
15 5 5 4 5 7 7 8
16 5 5 3 5 7 8 8
17 4 3 3 2 8 7 7
18 5 6 4 6 7 9 8
19 5 5 5 5 8 7 8
20 4 5 4 6 7 7 8
平均值 4.9 4.85 3.95 5.2 6.65 7.25 7.05
根据表3.4所示的结果可以看出，受试者在使用实施例3.1-3.7所制备的特护霜时，有比较明显的修复效果。
表3.5
受试者编号 对比例3.1 对比例3.2 对比例3.3 对比例3.4 对比例3.5
1 2 2 2 3 6
2 3 2 2 2 5
3 2 3 0 0 5
4 0 2 3 0 6
5 0 3 0 2 4
6 3 0 0 0 5
7 3 0 0 0 6
8 3 2 2 2 5
9 0 0 0 0 4
10 0 3 0 0 6
11 4 2 2 2 5
12 0 0 0 0 4
13 0 0 0 0 4
14 0 0 2 2 4
15 2 2 0 2 5
16 3 3 2 0 5
17 3 2 0 2 3
18 0 0 0 0 6
19 0 0 0 2 5
20 2 3 2 2 5
平均值 1.5 1.45 0.85 1.05 4.9
根据表3.5所示的结果可以看出，与实施例3.1-3.7相比，受试者在使用对比例3.1-3.4所制备的特护霜时，基本没有修复效果。
3.2、刺激性测试
以实施例3.1-3.7和对比例3.1-3.5作为测试样品，每组挑选30位20-30岁的有过过敏现象的女性受试者进行测试，每天早晚面部使用，使用量为(2.0±0.1)mg/cm 2(即0.0171g～0.0189g)。以调查问卷形式分别测试受试者使用产品时是否感觉到刺激性，结果如表3.6所示。
表3.6
受试者编号 有明显刺激感/人 有一点点刺激感/人 无刺激感/人
实施例3.1 0 0 30
实施例3.2 0 0 30
实施例3.3 0 0 30
实施例3.4 0 0 30
实施例3.5 0 0 30
实施例3.6 0 0 30
实施例3.7 0 0 30
对比例3.1 0 0 30
对比例3.2 0 0 30
对比例3.3 0 0 30
对比例3.4 1 4 25
对比例3.5 0 0 30
根据表3.6所示的结果可以看出，在使用对比例3.4所制备的特护霜时，有一人感到明显刺痛4人感到轻微刺痛，在试用其余对比例所制备的特护霜时，受试者均无刺痛感。
3.3、保湿效果测试
3.3.1短期保湿测试
以实施例3.1-3.7，对比例3.1-3.5作为测试样品，挑选20-30岁的女性受试者进行保湿测试。作为测试样品，志愿者前臂内侧区域，每个区域大小为3.0cm×3.0cm，样品用量为(2.0±0.1)mg/cm 2(即0.0171g～0.0189g)。分别测其初始及使用产品2小时、4小时后的角质层含水量作为样品的数值，其结果如表3.7所示。其中，编号1-10的测试者进行实施例3.1-3.3的测试；编号11-20的测试者进行实施例3.4-3.6的测试；编号21-30的测试者进行实施例3.7以及对比例3.1-3.2的测试；编号31-40的测试者进行对比例3.3-3.5的测试。
表3.7
Figure PCTCN2022088197-appb-000016
表3.7(续)
Figure PCTCN2022088197-appb-000017
根据表3.7的实验结果可以看出，相较于其他测试样品，对比例3.1、对比例3.2及对比例3.5所制备的样品在4小时保湿测试中，保湿效果较差，不及其他的样品。实施例3.1-3.7的短期保湿效果都非常显著。另外，从对比例3.4可以看出，屏障修复组分(一般是植物甾醇低芥酸菜籽油甘油酯类)具有一定的保湿效果。
3.3.2长效保湿测试
以实施例3.2-3.4作为测试样品，挑选20-30岁的女性受试者进行保湿测试。作为测试样品，志愿者前臂内侧区域，每个区域大小为3.0cm×3.0cm，样品用量为(2.0±0.1)mg/cm 2(即0.0171g～0.0189g)。分别测其初始及使用产品28天后的角质层含水量作为样品的数值，其结果如表3.8所示。
表38
Figure PCTCN2022088197-appb-000018
根据表3.8所示的结果可以看出，本公开实施例3.2-3.4的特护霜具有优异的保湿效果。因此，本公开的特护霜具有优异的保湿效果。
实施例四
按照下表4.1-4.3中的各组分的质量百分比，配制粉底液，其中，实施例中的粉底液的制备方法包括以下步骤：
1)准确称量各相。将A相过胶体磨研磨3次至分散均匀。
2)将B相、C相加入A相，搅拌加热至80-85℃，均质均匀后降至60℃。
3)将D、E、F、G相搅拌混合至完全溶解后，加入A、B、C混合相中，均质均匀后，持续搅拌降温。
4)当温度降至40℃以下时，将H、I相加入，搅拌均匀后出料。
表4.1实施例4.1-4.3
Figure PCTCN2022088197-appb-000019
表4.2实施例4.4-4.8
Figure PCTCN2022088197-appb-000020
表4.3实施例4.9-4.13
Figure PCTCN2022088197-appb-000021
对比例4.1-4.3
按照下表4.4中的各组分的质量百分比，按照与实施例4.1-4.3同样的方法制备相应的粉底液。
表4.4
Figure PCTCN2022088197-appb-000022
性能测试
4.1、修护效果评价
以对比例4.1-4.3及实施例4.1-4.3作为测试样品，挑选14组，每组10个20-30岁自评为干性敏感肌的女性受试者进行测试，每日取约0.3g，涂抹于面部，用美妆蛋轻拍上妆。以调查问卷形式测试受试者使用4周后的感觉。皮肤状态以10分计，皮肤干敏状态有改善为10分，皮肤问题没改善为0分，结果如 表4.5所示。
表4.5修护效果评价
Figure PCTCN2022088197-appb-000023
根据表4.5的实验结果可以看出，大部分受试者认为使用对比例4.3所制备的粉底液不能改善皮肤干敏的状态。在使用实施例4.4-4.8所制备的粉底液，一部分受试者认为自己的皮肤干敏状态有一定的缓和，另一部分认为没有效果。使用其余实施例所制备的粉底液的受试者，认为自己的皮肤状态改善比较明显。
4.2、舒缓效果评价
以对比例4.2及实施例4.1-4.13作为测试样品，挑选14组，每组20个20-30岁自评为干性敏感肌的女性受试者进行测试。取约0.3g，涂抹于面部，用美妆蛋轻拍上妆。以调查问卷形式收集受试者在使用后带妆8h内是否出现刺激、干、痒等情况。结果如表4.6所示。
表4.6干敏性皮肤刺激性测试
  总人数 使用后存在干痒刺激感 使用后无不适感
实施例4.1 20 0 20
实施例4.2 20 0 20
实施例4.3 20 0 20
实施例4.4 20 0 20
实施例4.5 20 0 20
实施例4.6 20 0 20
实施例4.7 20 0 20
实施例4.8 20 0 20
实施例4.9 20 2 18
实施例4.10 20 4 16
实施例4.11 20 3 17
实施例4.12 20 1 19
实施例4.13 20 1 19
对比例4.2 20 15 5
根据表4.6的实验结果可以看出，对于自评为干敏性的部分女性来说，实施例4.1-4.8所制备的粉底液经使用带妆8h内，不会出现干痒、刺激的不良反应。相比之下，实施例4.9-4.13及对比例4.2所制备的粉底液经使用带妆8h内，均有受试者出现干痒刺激等不良反应。
4.3、上妆效果评价
以对比例4.1及实施例4.1-4.5作为测试样品，挑选14组，每组10个20-30岁自评为干性敏感肌的女性受试者进行测试每日取约0.3g，涂抹于面部，用美妆蛋轻拍上妆。以调查问卷形式测试受试者使用时是否有卡粉、使用后8h内是否有干燥起皮现象，结果如表4.7所示。
表47上妆效果评价
Figure PCTCN2022088197-appb-000024
根据表4.7的实验结果可以看出，大部分受试者在使用实施例4.1-4.13所制备的粉底液时，没有出现卡粉和干燥起皮的现象。在使用对比例4.1所制备的粉底液时，部分使用者出现了卡粉和干燥起皮的现象。
以上所述，仅为本公开的具体实施方式，但本公开的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本公开揭露的技术范围内，可轻易想到变化或替换，都应涵盖在本公开的保护范围之内。因此，本公开的保护范围应以所述权利要求的保护范围为准。
实用性
根据本公开实施例所提供的保湿组合物、皮肤修护特护霜、粉底组合物及其制备方法可应用于护肤品、化妆品领域，能够有效起到保湿的作用。

Claims (21)

  1. 一种保湿组合物，其特征在于，以所述保湿组合物的总质量为100％计，包括以下组分：
    多元醇：60％～99.8％，优选为70％～94％；
    透明质酸或其盐：0.1％～10％，优选为0.3％～5％；
    神经酰脂：0.1％～30％，优选为1.5％～25％。
  2. 根据权利要求1所述的保湿组合物，其特征在于，所述多元醇、透明质酸或其盐以及神经酰脂的质量比为：100:(0.5-2.5):(1.5-25)。
  3. 根据权利要求1或2所述的保湿组合物，其特征在于，所述多元醇包括：甘油、1,4-丁二醇、戊二醇、1,2-丙二醇、1,3-丙二醇、二丙二醇、甲基丙二醇中的一种或两种以上的组合。
  4. 根据权利要求1-3任一项所述的保湿组合物，其特征在于，所述保湿组合物还包括D-泛醇，优选地，以所述保湿组合物的总质量为100％计，所述D-泛醇的加入量为：0.5％～30％，优选为4～25％。
  5. 根据权利要求4所述的保湿组合物，其特征在于，所述多元醇与所述D-泛醇的质量比为100：(4-25)。
  6. 一种根据权利要求1-5任一项所述的保湿组合物的制备方法，其特征在于，包括将所述保湿组合物的各组分混合的步骤。
  7. 一种保湿霜，其特片在于，包括根据权利要求1-5任一项所述的保湿组合物，以所述保湿霜的总质量为100％计，所述保湿组合物的加入量为0.1-10％；优选地，所述保湿霜还包括保湿剂、增稠剂、油脂、乳化剂以及防腐剂中的一种或两种以上的组合；更优选地，以所述保湿霜的总质量为100％计，所述保湿剂的加入量为0.01-10％；所述增稠剂的加入量为0.02-3％；所述油脂的加入量为5-25％；所述乳化剂加入量为0.05-5％；所述防腐剂的加入量为0.5-1.5％。
  8. 一种皮肤修护特护霜，其特征在于，以所述皮肤修护特护霜的总质量为100％计，包括以下组分：
    抗炎修复组分：0.13％-13％；
    保湿组分：1.02％-11.2％；以及
    屏障修复组分：0.11％-6％；其中
    所述保湿组分包括多元醇、透明质酸或其盐和神经酰脂。
  9. 根据权利要求8所述的皮肤修护特护霜，其特征在于，所述保湿组分中，以所述皮肤修护特护霜的总质量为100％计，所述多元醇的加入量为1％-10％；所述神经酰脂的加入量为0.01％-1％；所述透明质酸或其盐的加入量为0.01％-0.3％。
  10. 根据权利要求8或9所述的皮肤修护特护霜，其特征在于，所述抗炎修复组分包括羟基积雪草苷、多肽，广藿香叶提取物、丹参提取物中的一种或两种以上的组合；
    优选地，以所述皮肤修护特护霜的总质量为100％计，所述羟基积雪草苷的含量为0.01％-1％；所述多肽的含量为0.01％-5％；所述广藿香叶提取物的含量为0.01％-2％；所述丹参提取物的含量为0.1％-5％。
  11. 根据权利要求10所述的皮肤修护特护霜，其特征在于，所述多肽包括寡肽-1和/或棕榈酰四肽-7。
  12. 根据权利要求8-11任一项所述的皮肤修护特护霜，其特征在于，所述屏障修复组分包括神经酰胺和/或植物甾醇低芥酸菜籽油甘油酯类；
    优选地，以所述皮肤修护特护霜的总质量为100％计，所述神经酰胺的含量为0.01％-1％；所述植物甾醇低芥酸菜籽油甘油酯类的含量为0.1％-5％。
  13. 根据权利要求8-12任一项所述的皮肤修护特护霜，其特征在于，所述皮肤修护特护霜还包括乳化剂、润肤油脂、增稠剂以及防腐剂中的一种或两种以上的组合；
    优选地，所述乳化剂的含量为0.1-1％；所述润肤油脂的含量为1％-10％，所述增稠剂的含量为0.3％-1％，所述防腐剂的含量为0.1％-1％。
  14. 一种根据权利要求8-13任一项所述的皮肤修护特护霜的制备方法，其特征在于，包括将所述皮肤修护特护霜的各组分混合的步骤。
  15. 一种粉底组合物，其特征在于，以所述粉底组合物的总质量为100％计，包括以下组成：
    遮瑕组分：28.4％-70.8％，优选为30％-65％；
    修护组分：0.91％-3.6％，优选为1％-3％；
    保湿组分：3％-10％，优选为4％-9％；
    舒缓组分：0.3％-6％，优选为1-3％；其中，
    所述保湿组分包括多元醇、透明质酸或其盐和神经酰脂。
  16. 根据权利要求15所述的粉底组合物，其特征在于，所述遮瑕组分包括钛白粉，以所述粉底组合物的总质量为100％计，所述钛白粉的含量为12-24％；优选地，所述钛白粉的平均粒径为50nm-200nm。
  17. 根据权利要求16所述的粉底组合物，其特征在于，所述遮瑕组分还包括颜料、分散剂、润肤油脂、弹性体、硅石以及成膜剂中的一种或两种以上的组合；优选地，以所述粉底组合物的总质量为100％计，所述颜料的含量为0.1％-1.5％，所述分散剂的含量为0.3-1.5％，所述润肤油脂的含量为10-28.8％，所述弹性体的含量为2％-5％，所述成膜剂的含量为2％-5％；所述硅石的含量为2-5％。
  18. 根据权利要求15-17任一项所述的粉底组合物，其特征在于，所述修护组分包括精油、神经酰胺、植物甾醇低芥酸菜油甘油酯中的一种或两种以上的组合；优选地，以所述粉底组合物的总质量为100％计，所述精油的含量为0.4％-1.4％，所述神经酰胺的含量为0.01％-0.5％，所述植物甾醇低芥酸菜油甘油酯的含量为0.5-1.7％。
  19. 根据权利要求15-18任一项所述的粉底组合物，其特征在于，以所述粉底组合物的总质量为100％计，所述多元醇的含量为2.88％-8.8％，所述透明质酸或其盐的含量为0.02％-0.2％，所述神经酰脂的含量为0.1％-1％。
  20. 根据权利要求15-19任一项所述的粉底组合物，其特征在于，所述舒缓组分包括扭刺仙人掌提取物、黄芩提取物、羟基积雪草苷、广藿香叶提取物中的一种或两种以上的组合。
  21. 一种根据权利要求15-20任一项所述的粉底组合物的制备方法，其特征在于，包括将粉底组合物的各组分混合的步骤。
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