WO2022218302A9 - 一种力学性能提高的核酸水凝胶及其制备方法和用途 - Google Patents
一种力学性能提高的核酸水凝胶及其制备方法和用途 Download PDFInfo
- Publication number
- WO2022218302A9 WO2022218302A9 PCT/CN2022/086336 CN2022086336W WO2022218302A9 WO 2022218302 A9 WO2022218302 A9 WO 2022218302A9 CN 2022086336 W CN2022086336 W CN 2022086336W WO 2022218302 A9 WO2022218302 A9 WO 2022218302A9
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- WO
- WIPO (PCT)
- Prior art keywords
- nucleic acid
- acid hydrogel
- preparation
- improved mechanical
- use therefor
- Prior art date
Links
- 239000000017 hydrogel Substances 0.000 title abstract 5
- 102000039446 nucleic acids Human genes 0.000 title abstract 4
- 108020004707 nucleic acids Proteins 0.000 title abstract 4
- 150000007523 nucleic acids Chemical class 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 2
- 238000004132 cross linking Methods 0.000 abstract 3
- 238000004113 cell culture Methods 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 230000003832 immune regulation Effects 0.000 abstract 1
- 230000014616 translation Effects 0.000 abstract 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/0052—Preparation of gels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/0052—Preparation of gels
- B01J13/0065—Preparation of gels containing an organic phase
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
一种核酸水凝胶及其制备方法和用途。核酸水凝胶是由支架单元分别与交联单元I和交联单元II相交联形成，核酸水凝胶具有提高的力学强度与稳定性以及超分子水凝胶的动态特性。可用于药物递送、细胞培养分化、蛋白生产、免疫调控等生物医用领域，以及可穿戴设备、人造皮肤、软机器人等柔性电子领域。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110395102.8A CN113083172B (zh) | 2021-04-13 | 2021-04-13 | 一种力学性能提高的核酸水凝胶及其制备方法和用途 |
| CN202110395102.8 | 2021-04-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2022218302A1 WO2022218302A1 (zh) | 2022-10-20 |
| WO2022218302A9 true WO2022218302A9 (zh) | 2022-12-08 |
Family
ID=76676760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2022/086336 WO2022218302A1 (zh) | 2021-04-13 | 2022-04-12 | 一种力学性能提高的核酸水凝胶及其制备方法和用途 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN113083172B (zh) |
| WO (1) | WO2022218302A1 (zh) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113083172B (zh) * | 2021-04-13 | 2022-04-19 | 清华大学 | 一种力学性能提高的核酸水凝胶及其制备方法和用途 |
| WO2024027171A1 (zh) * | 2022-08-01 | 2024-02-08 | 清华大学 | 一种包含或由核酸水凝胶组成的佐剂及其用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002018270A (ja) * | 2000-07-03 | 2002-01-22 | Hiroshi Yoshioka | 合成ハイドロゲル |
| WO2008084571A1 (ja) * | 2007-01-12 | 2008-07-17 | Japan Science And Technology Agency | 核酸応答性ゲルおよびその製造方法ならびにその利用 |
| US8715732B2 (en) * | 2009-01-05 | 2014-05-06 | Cornell University | Nucleic acid hydrogel via rolling circle amplification |
| WO2014078636A1 (en) * | 2012-11-16 | 2014-05-22 | President And Fellows Of Harvard College | Nucleic acid hydrogel self-assembly |
| CN107773527B (zh) * | 2016-08-26 | 2021-06-25 | 清华大学 | 以核酸水凝胶作为载体的疫苗组合物 |
| CN107779427B (zh) * | 2016-08-26 | 2021-09-14 | 清华大学 | 核酸水凝胶在干细胞诱导分化中的用途 |
| CN107569448B (zh) * | 2017-09-06 | 2020-08-25 | 青岛大学 | 一种自组装dna水凝胶的制备方法及其应用 |
| CN109554331B (zh) * | 2017-09-27 | 2022-09-27 | 清华大学 | L-核酸水凝胶 |
| CN110180026B (zh) * | 2019-06-27 | 2021-02-09 | 清华-伯克利深圳学院筹备办公室 | 一种生物支架及其制备方法和应用 |
| CN112522373B (zh) * | 2021-02-03 | 2021-11-26 | 中国农业大学 | 一种蜘蛛网状自组装功能核酸水凝胶的制备方法 |
| CN113083172B (zh) * | 2021-04-13 | 2022-04-19 | 清华大学 | 一种力学性能提高的核酸水凝胶及其制备方法和用途 |
-
2021
- 2021-04-13 CN CN202110395102.8A patent/CN113083172B/zh active Active
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2022
- 2022-04-12 WO PCT/CN2022/086336 patent/WO2022218302A1/zh active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| CN113083172A (zh) | 2021-07-09 |
| CN113083172B (zh) | 2022-04-19 |
| WO2022218302A1 (zh) | 2022-10-20 |
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