WO2022215011A1 - USES OF ANTI-TGFβ ANTIBODIES AND OTHER THERAPEUTIC AGENTS FOR THE TREATMENT OF PROLIFERATIVE DISEASES - Google Patents

USES OF ANTI-TGFβ ANTIBODIES AND OTHER THERAPEUTIC AGENTS FOR THE TREATMENT OF PROLIFERATIVE DISEASES Download PDF

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Publication number
WO2022215011A1
WO2022215011A1 PCT/IB2022/053243 IB2022053243W WO2022215011A1 WO 2022215011 A1 WO2022215011 A1 WO 2022215011A1 IB 2022053243 W IB2022053243 W IB 2022053243W WO 2022215011 A1 WO2022215011 A1 WO 2022215011A1
Authority
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WIPO (PCT)
Prior art keywords
antibody
administered
seq
inhibitor
tgfβ
Prior art date
Application number
PCT/IB2022/053243
Other languages
English (en)
French (fr)
Inventor
Mirek DOSTALEK
Claire Fabre
Fariba KHANSHAN
Mark Shilkrut
Matthew Simon Squires
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Priority to EP22716516.4A priority Critical patent/EP4320150A1/en
Priority to JP2023561731A priority patent/JP2024513123A/ja
Priority to CN202280026875.1A priority patent/CN117098776A/zh
Publication of WO2022215011A1 publication Critical patent/WO2022215011A1/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591Stabilisation, fragmentation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PCT/IB2022/053243 2021-04-07 2022-04-06 USES OF ANTI-TGFβ ANTIBODIES AND OTHER THERAPEUTIC AGENTS FOR THE TREATMENT OF PROLIFERATIVE DISEASES WO2022215011A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP22716516.4A EP4320150A1 (en) 2021-04-07 2022-04-06 Uses of anti-tgf beta antibodies and other therapeutic agents for the treatment of proliferative diseases
JP2023561731A JP2024513123A (ja) 2021-04-07 2022-04-06 増殖性疾患を治療するための抗TGFβ抗体及び他の治療薬の使用
CN202280026875.1A CN117098776A (zh) 2021-04-07 2022-04-06 抗TGFβ抗体和其他治疗剂用于治疗增殖性疾病的用途

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US202163171786P 2021-04-07 2021-04-07
US63/171,786 2021-04-07
US202163181738P 2021-04-29 2021-04-29
US63/181,738 2021-04-29
US202163218679P 2021-07-06 2021-07-06
US63/218,679 2021-07-06
US202163236478P 2021-08-24 2021-08-24
US63/236,478 2021-08-24
US202163291665P 2021-12-20 2021-12-20
US63/291,665 2021-12-20
US202263320175P 2022-03-15 2022-03-15
US63/320,175 2022-03-15

Publications (1)

Publication Number Publication Date
WO2022215011A1 true WO2022215011A1 (en) 2022-10-13

Family

ID=81307898

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2022/053243 WO2022215011A1 (en) 2021-04-07 2022-04-06 USES OF ANTI-TGFβ ANTIBODIES AND OTHER THERAPEUTIC AGENTS FOR THE TREATMENT OF PROLIFERATIVE DISEASES

Country Status (4)

Country Link
EP (1) EP4320150A1 (zh)
JP (1) JP2024513123A (zh)
TW (1) TW202304979A (zh)
WO (1) WO2022215011A1 (zh)

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