WO2022211246A1 - Dispositif d'injection liquide - Google Patents

Dispositif d'injection liquide Download PDF

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Publication number
WO2022211246A1
WO2022211246A1 PCT/KR2022/001524 KR2022001524W WO2022211246A1 WO 2022211246 A1 WO2022211246 A1 WO 2022211246A1 KR 2022001524 W KR2022001524 W KR 2022001524W WO 2022211246 A1 WO2022211246 A1 WO 2022211246A1
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WO
WIPO (PCT)
Prior art keywords
catheter
needles
head
target
living body
Prior art date
Application number
PCT/KR2022/001524
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English (en)
Korean (ko)
Inventor
김준기
이상화
Original Assignee
재단법인 아산사회복지재단
울산대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by 재단법인 아산사회복지재단, 울산대학교 산학협력단 filed Critical 재단법인 아산사회복지재단
Publication of WO2022211246A1 publication Critical patent/WO2022211246A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/04—Endoscopic instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes

Definitions

  • the present invention relates to a liquid flow injection device.
  • liquids drugs, various reagents for procedures or diagnosis, cell therapy agents, stem cells, etc.
  • insert the needle of the syringe into the tissue layer of the living body and then apply force to the syringe.
  • the liquid contained in the percussion syringe is injected into the tissue layer.
  • the depth of the needle inserted into the tissue layer is controlled by the force of a person's hand operating the syringe, it may be difficult to precisely control the depth of the needle for the tissue layer.
  • the injection amount of the liquid per unit time is insufficient, the injection amount of cells can be increased by increasing the diameter of the needle, but when the diameter of the needle increases, the adjustable depth of the needle inserted into the tissue layer may be reduced.
  • a needle hole by the syringe is generated in the living body, or because the length of the needle is long, it is not easy to move along the curved part of the living body, and the needle may be bent.
  • various layers such as epidermal layer, connective layer, muscle layer, mesothelial layer, and secretory layer (Urothelium, Lamina intestinal, Muscular layer, and Serosa) are distributed in the biological tissue layer within a thickness of several hundred micrometers. It is not easy to inject accurately.
  • the target of the living body is located in a very narrow space such as the bladder and the large intestine, as the bending radius and the bending space of the endoscope are limited, the needle provided in the head of the endoscope cannot be vertically incident on the target of the living body, so the needle There was a problem that the drug could not be effectively delivered to the target of the living body.
  • the present invention has been devised to solve the above problems, and an object of the present invention is to effectively deliver a liquid to a target of a living body through a needle even when the target of the living body is located in a very narrow space such as the bladder and the large intestine. It is intended to provide a liquid flow injection device.
  • a liquid flow injection device for solving the above-described problems is provided to be able to enter and exit the biopsy channel, the catheter providing a movement path of the liquid flow; and a needle array provided in the catheter and having a plurality of needles for injecting the liquid into a target of a living body, wherein the head of the catheter includes an inclined portion inclined with respect to the central axis of the catheter, a plurality of The needle may be provided to protrude from the inclined portion.
  • the plurality of needles may further include a deformation unit for deforming the head of the catheter to be inserted into the target of the living body.
  • the deformation unit a support member coupled to the head of the catheter; and a pair of manipulation wires connected to the support member to deform the shape of the catheter head, and oppositely tension or relax the pair of manipulation wires to deform the head shape of the catheter, a plurality of the The direction or depth in which the needle is inserted into the biological target can be adjusted.
  • the support member has a closed loop shape, and the head of the pair of manipulation wires may be coupled to both sides of the support member, respectively.
  • the needle array the base coupled to the inclined portion; and a plurality of needles disposed on the base.
  • the plurality of needles may be provided to protrude from the inclined portion to a predetermined height.
  • the liquid flow injection device includes: a catheter provided to be able to enter and exit the biopsy channel and provide a movement path of the liquid flow; and a needle array provided in the catheter and including a plurality of needles for injecting the liquid into a target of a living body, wherein the plurality of needles may be provided in a transverse direction with respect to the central axis of the catheter.
  • the plurality of needles may further include a deformation unit for deforming an area of the catheter provided with the plurality of needles to be inserted into the target of the living body.
  • the deformable unit may include a plurality of unit joint parts arranged in a line along the longitudinal direction of the catheter to enable mutual articulation, and may deform a region of the catheter according to the joint motion of the unit joint part.
  • the deformation unit may include a pair of catheter wires coupled to the catheter, and may deform a region of the catheter by tensioning or relaxing the pair of catheter wires to the contrary.
  • the deformation unit may include a support member coupled to an area of the catheter; and a pair of manipulation wires connected to the support member to deform the shape of a region of the catheter, and tension or relaxation of the pair of manipulation wires to change the shape of a region of the catheter, , it is possible to adjust the direction or depth in which the plurality of needles are inserted into the biological target.
  • the support member has a closed loop shape, and the head of the pair of manipulation wires may be coupled to both sides of the support member, respectively.
  • the needle array the base coupled to the catheter; and a plurality of needles disposed on the base.
  • the catheter may include an elastically deformable material.
  • the liquid flow injection device can effectively deliver a liquid flow to a living body target through a plurality of needles even when the living body target is located in a very narrow space such as the bladder and large intestine.
  • a plurality of needles are provided on an inclined portion inclinedly formed in the head of the catheter, so that the plurality of needles can be inclinedly inserted with respect to the target of the living body, the contact surface between the needle and the living tissue This increases, the possibility of backflow of the liquid from the needle is reduced, and the amount of liquid delivered from the needle to the living body can be improved.
  • FIG. 1 is a perspective view showing a liquid injection device according to a first embodiment of the present invention.
  • Figure 2 is an enlarged view showing the needle array according to the first embodiment of the present invention.
  • FIG 3 is a schematic view showing a state in which a plurality of needles of the liquid injection device according to the first embodiment of the present invention are inserted into the tissue layer.
  • FIGS. 4A and 4B are schematic diagrams illustrating examples of a deformable unit of the liquid flow injection device according to the first embodiment of the present invention.
  • FIG. 5 is a perspective view illustrating a liquid flow injection device according to a second embodiment of the present invention.
  • 6 to 8B are schematic diagrams showing various examples of the deformable unit of the liquid flow injection device according to the second embodiment of the present invention.
  • FIG. 1 is a perspective view showing a liquid injection device according to a first embodiment of the present invention
  • Figure 2 is an enlarged view showing a needle array according to the first embodiment of the present invention.
  • the liquid flow injection device includes a biopsy channel 10 , a catheter 40a and a needle array 50 .
  • the distal end of the catheter 40a facing the biological target and the distal end of the biopsy channel 10 are referred to as a catheter head and a biopsy channel head, respectively.
  • the biopsy channel 10 may be an endoscopic channel used for endoscopy/procedure, but is not limited thereto, and the biopsy channel 10 may be a separate channel for injecting a liquid into a target of a living body. Of course.
  • liquids include drugs, various reagents for procedure or diagnosis, cell therapy agents, stem cells, etc., and include liquids as well as semi-liquids (semi-solids such as hydrogels) surrounding the therapeutic agents/cells.
  • semi-liquids semi-liquids (semi-solids such as hydrogels) surrounding the therapeutic agents/cells.
  • a biopsy lamp 20 and a biopsy camera 30 may be provided at the head of the biopsy channel 10 .
  • One or more biopsy lamps 20 may be provided at the head of the biopsy channel 10 .
  • the biopsy lamp 20 may project a specific pattern capable of improving the identification of the target of the living body.
  • the specific pattern may be in the form of a grid. Accordingly, it is possible to provide the user with an image image of the target of the living body with improved identification by the specific pattern projected on the target of the living body.
  • the biopsy camera 30 may provide a video image of the target of the living body to the user by photographing the target of the living body from the head of the biopsy channel 10 .
  • the video image of the target of the living body may be displayed on a display (not shown) provided outside the living body.
  • the user may accurately inject the liquid into the target of the living body while checking the video image of the biopsy camera 30 .
  • the user may check the bleeding or leakage of the target of the living body in real time while checking the video image of the biopsy camera 30 .
  • the catheter 40a is provided to be in and out of the biopsy channel 10, and provides a movement path of the liquid.
  • the catheter 40a may adjust the length of entering and leaving the head of the biopsy channel 10 to adjust the depth of insertion into the target of the living body.
  • the head of the catheter 40a may include an inclined portion 41 formed to be inclined with respect to the central axis of the catheter 40a. Also, the inclined portion 41 may be inclined with respect to the central axis of the head of the biopsy channel 10 .
  • the head of the biopsy channel 10 or the head of the catheter 40a may be deformed, and the head of the catheter 40a to be described later by the deformation of the head of the biopsy channel 10 or the head of the catheter 40a.
  • the provided plurality of needles 52 may be inserted into the target of the living body.
  • the catheter 40a may include an elastically deformable material.
  • the needle array 50 is provided in the head of the catheter 40a, and includes a plurality of needles 52 for injecting a liquid into a target of a living body.
  • a plurality of needles 52 are provided to protrude from the inclined portion 41 formed in the head of the catheter (40a).
  • the plurality of needles 52 may be provided to protrude from the inclined portion 41 to a predetermined height. In other words, the plurality of needles 52 are provided to protrude from the inclined portion 41 at the same height. Accordingly, the plurality of needles 52 may be inserted into the target of the living body at the same depth.
  • the needle array 50 may include a plurality of needles 52 each coupled to the inclined portion 41 .
  • the angles of the plurality of needles 52 may be individually changed according to the change in the angle of the inclined portion 41 .
  • the needle array 50 may include a base 51 coupled to the inclined portion 41 and a plurality of needles 52 disposed on the base 51 .
  • the needle array 50 is provided in a bundle type in which the angle of the plurality of needles 52 is integrally changed according to the change in the angle of the base 51 . Accordingly, the angle of the plurality of needles 52 may be integrally changed according to the change in the angle of the inclined portion 41 .
  • FIG. 3 is a schematic diagram illustrating a state in which a plurality of needles of the liquid injection device according to the first embodiment of the present invention are inserted into a living body target.
  • the target of the living body is reached.
  • the user can accurately inject the liquid into the target of the living body while checking the video image of the biopsy camera 30 .
  • the user may check the bleeding or leakage of the target of the living body in real time while checking the video image of the biopsy camera 30 .
  • the user transforms the head of the biopsy channel 10 or the head of the catheter 40a in a direction in which the plurality of needles 52 are inserted into the target of the living body, so that the plurality of needles ( After the 52 is inserted into the target of the living body, the liquid flow is injected into the target of the living body through the plurality of needles 52 .
  • a plurality of needles 52 are provided on the inclined portion 41 formed to be inclined to the head of the catheter 40a, so that even with very little deformation of the head of the biopsy channel 10 or the head of the catheter 40a, a plurality of needles (52) can be inserted into the target of the living body.
  • the head of the biopsy channel 10 or the head of the catheter 40a is deformed very slightly, and the drug is injected through the plurality of needles 52 It can be effectively delivered to the target of the living body.
  • the plurality of needles 52 are provided on the inclined portion 41 formed to be inclined in the head of the catheter 40a, the plurality of needles 52 may be inserted inclined with respect to the target of the living body, so that the needle 52 and The contact surface between living tissues is increased, the possibility of backflow of the liquid from the needle 52 is reduced, and the amount of liquid transferred from the needle 52 to the living body can be improved.
  • FIGS. 4A and 4B are schematic diagrams illustrating examples of a deformable unit of the liquid flow injection device according to the first embodiment of the present invention.
  • the liquid injection device according to the first embodiment of the present invention is a deformation unit ( 60) may be further included.
  • the deformation unit 60 may include a support member 61 and a pair of manipulation wires 62 .
  • the support member 61 is coupled to the head of the catheter 40a.
  • the support member 61 may have a closed loop shape, for example, may be formed in a circular shape.
  • the support member 61 is connected to a pair of operating wires 62 to be described later.
  • a pair of operating wires 62 are connected to the support member 61 to deform the shape of the catheter 40a head. Specifically, by tensioning or relaxing the pair of manipulation wires 62 oppositely, the head shape of the catheter 40a is changed, and the direction or depth in which the plurality of needles 52 are inserted into the target of the living body can be adjusted. .
  • a pair of manipulation wires 62 will be defined as a first manipulation wire 62a and a second manipulation wire 62b connected to both sides of the support member 61 .
  • one side of the head of the catheter 40a is spaced apart from the target of the living body and The other side of the head of the catheter 40a approaches the target of the living body, and the head of the catheter 40a may be bent.
  • a plurality of needles 52 provided in the head of the catheter 40a may be inserted into the target of the living body.
  • the head of the catheter 40a may be bent. At this time, the plurality of needles 52 provided in the head of the catheter 40a may be discharged from the target of the living body.
  • FIG. 5 is a perspective view illustrating a liquid flow injection device according to a second embodiment of the present invention.
  • the liquid injection device includes a biopsy channel 10 , a catheter 40b and a needle array 50 , but unlike the first embodiment, a needle Array 50 may be provided transverse to the central axis of catheter 40b.
  • the plurality of needles 52 may be provided in a transverse direction with respect to the central axis of the catheter 40b. In other words, the plurality of needles 52 may be provided on the outer peripheral surface of the head of the catheter (40b).
  • the plurality of needles 52 may be provided to protrude from the catheter 40b at a predetermined height. Accordingly, the plurality of needles 52 may be inserted into the target of the living body at the same depth.
  • the needle array 50 may include a plurality of needles 52 each coupled to the catheter 40b.
  • the angles of the plurality of needles 52 may be individually changed according to the change in the angle of the inclined portion 41 .
  • the needle array 50 may include a base 51 coupled to the catheter 40b and a plurality of needles 52 disposed on the base 51 .
  • the needle array 50 is provided in a bundle type in which the angle of the plurality of needles 52 is integrally changed according to the change in the angle of the base 51 . Accordingly, the angle of the plurality of needles 52 may be integrally changed according to the change in the angle of the inclined portion 41 .
  • the target of the living body is reached.
  • the user can accurately inject the liquid into the target of the living body while checking the video image of the biopsy camera 30 .
  • the user may check the bleeding or leakage of the target of the living body in real time while checking the video image of the biopsy camera 30 .
  • the user deforms the head of the biopsy channel 10 or the head of the catheter 40b in a direction in which the plurality of needles 52 are inserted into the target of the living body, and the plurality of needles 52 are inserted into the target of the living body After that, the liquid flow is injected into the target of the living body through the plurality of needles 52 .
  • the plurality of needles 52 are provided in the transverse direction with respect to the central axis of the catheter 40b, so that even a very small deformation of the head of the biopsy channel 10 or the head of the catheter 40b, the plurality of needles 52 It can be inserted into the target of the living body.
  • the plurality of needles 52 are provided in the transverse direction with respect to the central axis of the catheter 40b, even when the target of the living body is located in a very narrow space such as the bladder and the large intestine, the head of the biopsy channel 10 or By very slightly deforming the head of the catheter 40b, the liquid flow can be effectively delivered to the target of the living body through the plurality of needles 52 .
  • 6 to 8B are schematic diagrams showing various examples of the deformable unit of the liquid flow injection device according to the second embodiment of the present invention.
  • the liquid injection device is a catheter 40b provided with a plurality of needles 52 so that the plurality of needles 52 are inserted into the target of the living body. It may include a deformation unit 60 that deforms an area of .
  • the deformation unit 60 may include a plurality of unit joint parts 63 .
  • the plurality of unit joint portions 63 may be arranged in a line along the longitudinal direction of the catheter 40b to enable mutual joint movement, and one region of the catheter 40b may be deformed according to the joint motion of the unit joint portion 63. have. At this time, the plurality of unit joint parts 63 may be jointly moved by tension or relaxation of a joint wire (not shown) penetrating and connecting the plurality of unit joint parts 63 .
  • the deformation unit 60 may include a pair of catheter wires 64 .
  • the pair of catheter wires 64 is coupled to the catheter 40b, and the pair of catheter wires 64a and 64b are tensioned or relaxed in opposite directions to deform an area of the catheter 40b.
  • a pair of catheter wires 64 will be defined as a first catheter wire 64a and a second catheter wire 64b connected to both sides of the catheter 40b.
  • the head of the catheter 40b when the first catheter wire 64a is tensioned and the second catheter wire 64b is relaxed, one side of the head of the catheter 40b is spaced apart from the target of the living body and the other side of the head of the catheter 40b is the body's In the form of approaching the target, the head of the catheter 40b may be bent.
  • the head of the catheter 40b may be bent.
  • a plurality of needles 52 provided in the head of the catheter 40b by bending and deforming the head of the catheter 40b into a desired shape with a pair of catheter wires 64 are inserted or inserted according to the target shape of the living body. can be emitted.
  • the deformation unit 60 may include a support member 61 and a pair of manipulation wires 62 .
  • the support member 61 is coupled to the head of the catheter 40b.
  • the support member 61 may have a closed loop shape, for example, may be formed in a circular shape.
  • the support member 61 is connected to a pair of operating wires 62 to be described later.
  • a pair of operating wires 62 are connected to the support member 61 to deform the shape of the catheter 40b head. Specifically, by tensioning or relaxing the pair of manipulation wires 62 oppositely, the head shape of the catheter 40b is changed, and the direction or depth in which the plurality of needles 52 are inserted into the target of the living body can be adjusted. .
  • a pair of manipulation wires 62 will be defined as a first manipulation wire 62a and a second manipulation wire 62b connected to both sides of the support member 61 .
  • one side of the head of the catheter 40b is spaced apart from the target of the living body and The other side of the head of the catheter 40b approaches the target of the living body, and the head of the catheter 40b may be bent.
  • the head of the catheter 40b may be bent.
  • the plurality of needles 52 provided in the head of the catheter 40b by bending the head of the catheter 40b may be inserted or discharged into the target of the living body.
  • the drug is injected into the target of the living body through the plurality of needles 52 . can be communicated effectively.
  • a plurality of needles 52 are provided on the inclined portion 41 formed to be inclined at the head of the catheter 40b, so that the plurality of needles 52 is a target of the living body. Since it can be inserted obliquely with respect to the needle 52, the contact surface between the needle 52 and the living tissue is increased, the possibility of backflow of the liquid from the needle 52 is reduced, and the amount of liquid transferred from the needle 52 to the living body is reduced. can be improved

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Abstract

La présente invention concerne un dispositif d'injection liquide comprenant : un cathéter qui est prévu pour être rétractable à l'intérieur et extensible depuis un canal de biopsie et fournit un trajet de mouvement pour un liquide ; et un réseau d'aiguilles qui est disposé dans le cathéter et qui comprend une pluralité d'aiguilles pour l'injection du liquide dans une cible d'un corps vivant, la tête du cathéter comprenant une partie inclinée qui est formée pour être inclinée vers l'axe central du cathéter, et la pluralité des aiguilles sont prévues pour faire saillie depuis la partie inclinée.
PCT/KR2022/001524 2021-03-29 2022-01-27 Dispositif d'injection liquide WO2022211246A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020210040326A KR102337886B1 (ko) 2021-03-29 2021-03-29 액체류 주입 장치
KR10-2021-0040326 2021-03-29

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WO2022211246A1 true WO2022211246A1 (fr) 2022-10-06

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102337886B1 (ko) * 2021-03-29 2021-12-09 재단법인 아산사회복지재단 액체류 주입 장치

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070049863A1 (en) * 2003-01-14 2007-03-01 Jahns Scott E Devices and methods for interstitial injection of biologic agents into tissue
JP2010154895A (ja) * 2008-12-26 2010-07-15 Olympus Corp 内視鏡装置
JP2016005543A (ja) * 2014-05-26 2016-01-14 株式会社スズキプレシオン 注入針装置及び注入器具セット
KR20210021189A (ko) * 2019-08-14 2021-02-25 울산대학교 산학협력단 니들 어레이를 이용한 액체류 주입 장치
KR102337886B1 (ko) * 2021-03-29 2021-12-09 재단법인 아산사회복지재단 액체류 주입 장치

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8585584B2 (en) 2004-10-11 2013-11-19 Nitesh Ratnakar Dual view endoscope

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070049863A1 (en) * 2003-01-14 2007-03-01 Jahns Scott E Devices and methods for interstitial injection of biologic agents into tissue
JP2010154895A (ja) * 2008-12-26 2010-07-15 Olympus Corp 内視鏡装置
JP2016005543A (ja) * 2014-05-26 2016-01-14 株式会社スズキプレシオン 注入針装置及び注入器具セット
KR20210021189A (ko) * 2019-08-14 2021-02-25 울산대학교 산학협력단 니들 어레이를 이용한 액체류 주입 장치
KR102337886B1 (ko) * 2021-03-29 2021-12-09 재단법인 아산사회복지재단 액체류 주입 장치

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