WO2022194296A1 - 一种检测装置 - Google Patents

一种检测装置 Download PDF

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Publication number
WO2022194296A1
WO2022194296A1 PCT/CN2022/081845 CN2022081845W WO2022194296A1 WO 2022194296 A1 WO2022194296 A1 WO 2022194296A1 CN 2022081845 W CN2022081845 W CN 2022081845W WO 2022194296 A1 WO2022194296 A1 WO 2022194296A1
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WIPO (PCT)
Prior art keywords
detection device
pad
support plate
sample
hydrophobic element
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PCT/CN2022/081845
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English (en)
French (fr)
Inventor
孔健希
郑珍珍
商涛
费凤琴
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艾康生物技术(杭州)有限公司
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Publication of WO2022194296A1 publication Critical patent/WO2022194296A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the invention belongs to the technical field of biological detection, and particularly relates to the structure of a detection device.
  • POCT point-of-care testing
  • Lateral Flow Test Strip is a commonly used instant detection product.
  • the lateral lateral flow detection device utilizes the principle of chromatography to realize the transfer of the sample on the test paper.
  • the lateral lateral flow detection device 100 generally includes a support plate 1. On the support plate from upstream to downstream, there are adherents superimposed on each other in sequence. Sample pad 2 , marker conjugate release pad 3 , reaction membrane 4 and water absorption pad 5 .
  • a detection line 41 and a control line 42 are generally provided on the reaction membrane, and the control line may be upstream or downstream of the detection line, and some detection devices may not have a control line.
  • the signal of the detection line on the reaction membrane is linearly correlated with the content of the analyte in the sample to be detected, so as to determine whether the analyte or the concentration of the analyte exists in the sample.
  • the lateral cross-flow detection device can be assembled in a detection plate composed of upper and lower cover plates, and the absorbent pad is not exposed to the external environment. It may also be the detection device 101 in the form of a test paper as shown in FIG. 2 , and a sticker 6 is pasted on the sample pad and the marker conjugate release pad of the detection device.
  • the solution to be tested can be added dropwise to the sample pad of the detection device, or the lateral flow detection device 101 can be inserted into the small tube containing the solution to be tested as shown in FIG. in the solution to be tested.
  • the solution to be tested on the sample pad flows through the labeled conjugate release pad, the reaction membrane in sequence, and is finally absorbed by the water absorption pad.
  • the detection device 101 in the form of test paper as shown in FIG. 4 , the user needs to hold the absorbent pad and take out the detection device from the small tube to observe the detection result or discard the detection device.
  • the solution to be tested contains infectious pathogenic viruses or bacteria, such as HBV, HCV, HIV, malaria, dengue fever, influenza, Middle East respiratory syndrome, SARS and new coronavirus antigen 2019-nCoV, these pathogenic factors (virus or bacteria, etc.) will remain on the absorbent pad. Once the user does not wear gloves or other improper operation behavior, the fingers on the absorbent pad will come into contact with these pathogenic factors, which poses a great risk of infection.
  • infectious pathogenic viruses or bacteria such as HBV, HCV, HIV, malaria, dengue fever, influenza, Middle East respiratory syndrome, SARS and new coronavirus antigen 2019-nCoV
  • the present invention provides a new and safe detection device.
  • An object of the present invention is to provide a detection device, comprising a support plate on which a sample processing pad, a reaction film and a water absorbing pad are stacked in sequence from upstream to downstream, and at the downstream end of the water absorbing pad of the detection device With hydrophobic elements.
  • the hydrophobic element is the front end of the support plate, and the material of the front end is a hydrophobic material and is not covered by the absorbent pad.
  • the hydrophobic element is a blocking block.
  • the blocking block is adhered to the support plate downstream of the absorbent pad.
  • the hydrophobic element is a handle.
  • sample processing pad may include an independent sample pad and a labeled conjugate release pad, and the sample pad and the labeled conjugate release pad are superimposed on each other and adhered to the support plate in sequence from upstream to downstream.
  • the self-adhesive sticker is provided with an indicator mark of the hand-kneading area corresponding to the hydrophobic element.
  • a detection line and a control line are arranged on the reaction membrane.
  • the area of the hydrophobic element is sized so that the user's fingers can hold the detection device without touching the absorbent pad.
  • Another object of the present invention is to provide a method for preparing a detection device, including providing a support plate; pasting a detection pad on the support plate, coating a detection line with a detection reagent on the detection pad, and after the detection pad is dried, A sample processing pad and a water absorbing pad are sequentially pasted on the superimposed stickers on the support plate, and a hydrophobic element is arranged downstream of the water absorbing pad.
  • hydrophobic element is a blocking block.
  • sample processing pad includes a sample pad and a labeled conjugate releasing pad that are superimposed on each other from upstream to downstream.
  • the beneficial effect of the present invention is that a hydrophobic element is arranged at the front end of the detection device, and the hydrophobic element as the pinching area can prevent the sample solution on the absorbent pad from further flowing to the area where the user is handling the detection device.
  • the detection device of the present invention is used for detection, especially when detecting samples with infectious viruses or bacteria, even if the user does not wear gloves or other improper operation behavior, the user will not or easily touch it. these pathogenic factors, thereby reducing the risk of infection.
  • Fig. 1 is a schematic diagram of the detection device in the prior art, the water absorbing pad covers the foremost end of the support plate.
  • FIG. 2 is a schematic diagram of a detection device with self-adhesive stickers in the prior art.
  • Figure 3 is a schematic diagram of the insertion of the detection device into the sample vial.
  • FIG. 4 is a schematic diagram of a user taking out the detection device from the sample vial while pinching the upper end of the detection device.
  • FIG. 5 is a schematic diagram of a detection device of the present invention, the front end of the support plate is not covered by the water-absorbing pad.
  • FIG. 6 is a schematic diagram of a detection device with a self-adhesive sticker according to the present invention.
  • Fig. 7 is a schematic diagram of a detection device with a blocking block according to the present invention, and the blocking block is located downstream of the water-absorbing pad.
  • Figure 8 Schematic diagram of a support plate covered with a sticker.
  • Figure 9 is an exploded view of the detection device installed in the detection board.
  • the detection device 103 is a lateral flow detection device, including a support plate 1 on which a sample pad 2 , a labeled conjugate release pad 3 , and a reaction membrane are superimposed on each other in sequence from upstream to downstream. 4 and the water absorbing pad 5, a detection line 41 and a control line 42 are arranged on the reaction membrane, and a hydrophobic element 7 is arranged on the downstream end of the water absorbing pad 5, and the area of Get test strips here.
  • the size of the area of the hydrophobic element is such that the user's fingers can hold the detection device without touching the absorbent pad.
  • the upper edge 51 of the absorbent pad shown in FIG. 5 , FIG. 6 , and FIG. 7 is not aligned with the upper edge 11 of the support plate, and has a certain distance.
  • the specific value of the distance is suitable for the user to hold the detection device without touching the absorbent pad, so as to reduce the probability of the user touching the absorbent pad as much as possible.
  • the downstream end of the absorbent pad that is, the front end of the support plate 1 is not covered by the absorbent pad, and the material of the front end is a hydrophobic material, as the present invention the hydrophobic element.
  • the detection device 105 includes a support plate 1 on which a sample pad 2 , a labeled conjugate release pad 3 , a reaction membrane 4 , a water absorption pad 5 and Block 8 as a hydrophobic element.
  • the material of the blocking block 8 is hydrophobic, and the sample solution flowing onto the absorbent pad will not be absorbed by the blocking block.
  • the detection device is similar to Figures 5, 6, and 7, the difference is that the upper edge of the absorbent pad is aligned with the upper edge of the support plate, and a handle is installed in the pinching area of the detection device, and the handle is made of hydrophobic material .
  • the detection device shown in FIG. 6 is based on FIG. 5 , and a self-adhesive sticker 6 is pasted on the sample pad and the marker combination release pad of the detecting device, and a self-adhesive sticker 6 is pasted on the water-absorbing pad and part of the support plate. .
  • the corresponding parts of the detection device shown in FIG. 7 can also be pasted with self-adhesive stickers.
  • a hand pinching area indication mark is set on the sticker corresponding to the hand pinching area, which is used to prompt the user to pinch the finger here, so as to further prevent the user from holding the hand pinching area. In the wrong position, it is contaminated by the remaining solution to be tested.
  • the indication mark may be a pattern, such as the pattern 61 of a hand, or a color indication different from other areas.
  • a layer of transparent self-adhesive sticker is pasted on the reaction film.
  • the sample pad and the labeled conjugate release pad can be processed into one pad, and the same material is used.
  • the detection device includes a support plate, on which sample processing pads are adhered and superimposed on each other sequentially from upstream to downstream. , reaction membrane and absorbent pad, a hydrophobic element is arranged between the upper edge 51 of the absorbent pad 5 and the upper edge 11 of the support plate 1, the sample processing pad is processed with a labeled conjugate, and after the sample is added to the sample processing pad, the The analyte reacts with the label conjugate on the pad.
  • the material of the support plate is selected from hydrophobic polyester (PET) rubber sheet, polyvinyl chloride (PVC) rubber sheet, polypropylene (PP) rubber sheet, and polycarbonate (PC) rubber sheet. These hydrophobic materials can also be used as The material of the hydrophobic element.
  • PET hydrophobic polyester
  • PVC polyvinyl chloride
  • PP polypropylene
  • PC polycarbonate
  • the material of the sample pad is selected from glass cellulose, polyester film, polyester fiber film, non-woven fabric, and filter paper.
  • the material of the labeled conjugate release pad is selected from glass cellulose, polyester film, polyester fiber film, and non-woven fabric.
  • the material of the reaction membrane is selected from NC membrane and nitrocellulose membrane.
  • the material of the absorbent pad is selected from cellulose filter paper, absorbent paper, and filter paper.
  • the material of the self-adhesive sticker is selected from hydrophobic coated paper, transparent polyvinyl chloride (PVC), electrostatic polyvinyl chloride (PVC), polyester (PET), laser paper, temperature-resistant paper, polypropylene (PP), polyethylene Carbonate (PC), Kraft paper, Fluorescent paper, Gold-plated paper, Silver-plated paper, Synthetic paper, Aluminum foil paper, Fragile (anti-counterfeiting) paper, Textured paper, Cloth label (Tyvec/Nylon) paper, Pearl paper, Sandwich Coated paper, thermal paper.
  • the preparation method of the detection device shown in FIG. 5 The support plate 10 shown in FIG. 8 is provided.
  • the support plate 1 is pre-pasted with a self-adhesive sticker 12 corresponding to the hydrophobic element of the detection device, the self-adhesive sticker 13 is pre-pasted in the position corresponding to the absorbent pad, and the non-drying sticker is pre-pasted in the position corresponding to the reaction film.
  • the self-adhesive sticker 12 may or may not be removed.
  • the blocking block 8 is attached here, and then the self-adhesive sticker 13 is removed, and the upper edge of the absorbent pad is pasted along the lower edge of the blocking block 8 .
  • the blocking block 8 plays a role in positioning the sticking of the absorbent pad.
  • the detection device of the present invention is assembled in a detection board, and the detection board includes an upper cover 111 and a lower board 112 that can be fastened to each other. Since the detection device has the hydrophobic element 7, it can be avoided that the residual test solution slowly penetrates out of the detection plate through the hydrophobic element. Thereby, the risk of the user being infected by contact with the residual test solution can be effectively avoided or reduced.

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Abstract

本发明提供了一种检测装置，包括支撑板，在支撑板上从上游到下游依次叠加的粘附有样品处理垫、反应膜和吸水垫，在检测装置的吸水垫下游端设有疏水性元件。作为拿捏区域的疏水性元件可以阻止在吸水垫上的样品溶液进一步流动到使用者拿捏检测装置的区域。本发明所述的检测装置能有效降低使用者在实行样品检验时的感染风险，特别是在检测传染性疾病，例如HBV、HIV、疟疾、登革热、SARS和新冠等样品时的感染风险。

Description

一种检测装置 技术领域
本发明属于生物检测技术领域，特别涉及检测装置的结构。
背景技术
目前，越来越多能实现现场采样并可立即获得检测结果的产品被研究和应用于临床，这类检测通常被称为即时检验(point-of-care testing，POCT)。例如侧向横流检测装置(Lateral Flow Test Strip)是目前常用的即时检测产品。
侧向横流检测装置利用层析原理实现样品在试纸上的传递，如图1所示侧向横流检测装置100，一般包括支撑板1，在支撑板上从上游到下游依次相互叠加的粘附有样品垫2、标记结合物释放垫3、反应膜4和吸水垫5。在反应膜上一般设有检测线41和对照线42，对照线可以在检测线的上游或下游，在一些检测装置上也可以不设对照线。反应膜上检测线的信号与待检测样本中被分析物的含量呈线性相关，从而判断出样品中是否存在被分析物或被分析物的浓度。侧向横流检测装置可以装配在由上下盖板组成的检测板中，吸水垫并不暴露在外环境中。也可以是如图2所示试纸形式的检测装置101，在检测装置的样品垫和标记结合物释放垫上粘贴有不干胶贴纸6。
待测溶液可以通过滴加的方式将其添加到检测装置的样品垫上，也可以通过如图3所示，侧向横流检测装置101插入至装有待测溶液的小管中，使样品垫浸泡在待测溶液中。样品垫上的待测溶液顺次流过标记结合物释放垫、反应膜，并最终被吸水垫吸收。当采用试纸形式的检测装置101时，如图4所示，使用者需要拿捏在吸水垫处，并从小管中取出检测装置以观察检测结果或丢弃检测装置。如果待测溶液中包含具传染性的致病病毒或细菌，例如HBV、HCV、HIV、疟疾、登革热、流感、中东呼吸综合征、SARS和新冠抗原2019-nCoV等，这些致病因子(病毒或细菌等)就会残留在吸水垫上。一旦使用者未带手套或其他不当的操作行为，会导致拿捏在吸水垫上的手指接触到这些致病因子，这存在极大的感染风险。
发明内容
为了解决使用者因与吸水垫接触而被残存在吸水垫上的致病因子感染的问题。本发明提供了一种新安全的检测装置。
本发明的一个发明目的是提供了一种检测装置，包括支撑板，在支撑板上从上游到下游依次叠加的粘附有样品处理垫、反应膜和吸水垫，在检测装置的吸水垫下游端设有疏水性元件。
优选的，疏水性元件为支撑板的前端，所述前端的材料为疏水性材料并且不被吸水垫覆盖。
优选的，所述疏水性元件为一个阻挡块。
优选的，阻挡块粘附在位于吸水垫下游的支撑板上。
优选的，所述疏水性元件为手柄。
进一步的，所述样品处理垫可包括独立的样品垫和标记结合物释放垫，样品垫和标记结合物释放垫从上游到下游依次相互叠加的粘附在支撑板上。
进一步的，在样品处理垫、吸水垫上粘贴有不干胶贴纸。
优选的，不干胶贴纸相应于疏水元件处设有手捏区指示标记。
进一步的，在反应膜上设有检测线和对照线。
优选的，疏水性元件的区域大小以能满足使用者手指能拿住检测装置但又不会碰到吸水垫。
本发明的另一个目的是提供了一种检测装置的制备方法，包括提供一个支撑板；在支撑板上粘贴检测垫，在检测垫上包被带有检测试剂的检测线，待检测垫干燥后，在支撑板上相互叠加的粘贴上依次粘贴上样品处理垫和吸水垫，在吸水垫的下游设置疏水性元件。
进一步的，疏水性元件为阻挡块。
进一步的，样品处理垫包括从上游至下游相互叠加的样品垫和标记结合物释放垫。
进一步的，在样品处理垫和吸水垫上表面粘贴一层不干胶贴纸。
本发明的有益效果是：在检测装置的前端设置疏水性元件，作为拿捏区域的疏水性元件可以阻止吸水垫上的样品溶液进一步流动到使用者拿捏检测装置的区域。采用本发明所述的检测装置进行检测时，特别是检测带有传染性病毒或细 菌的样品时，即使使用者未带手套或其他不当的操作行为时，使用者也不会或不容易接触到这些致病因子，从而降低感染风险。
附图说明
图1现有技术中的检测装置示意图，吸水垫覆盖住了支撑板的最前端。
图2现有技术中带有不干胶贴纸的检测装置示意图。
图3检测装置插入至样品小管中的示意图。
图4使用者手捏在检测装置的上端，从样品小管中取出检测装置的示意图。
图5本发明的一种检测装置示意图，支撑板的前端未被吸水垫覆盖。
图6本发明带有不干胶贴纸的检测装置示意图。
图7本发明带有阻挡块的检测装置示意图，阻挡块位于吸水垫的下游。
图8覆盖有不干胶贴纸的支撑板示意图。
图9是检测装置安装在检测板中的分解图。
具体实施方式
如图5所示的检测装置103为侧向横流检测装置，包括支撑板1，在支撑板1上从上游到下游依次相互叠加的粘附有样品垫2、标记结合物释放垫3、反应膜4和吸水垫5，在反应膜上设有检测线41和对照线42，吸水垫5的下游端设有疏水性元件7，疏水性元件的区域可以作为手捏区，使用者的手拿捏在此处以拿取试纸。在一个优选的示例中，疏水性元件的区域大小以能满足使用者手指能拿住检测装置但又不会碰到吸水垫为宜。
与图1相比，图5、图6、图7所示吸水垫的上边沿51与支撑板的上边沿11不对齐，具有一定的距离。在一个优选的实例中，该距离的具体数值以能满足使用者手指能拿住检测装置但又不会碰到吸水垫为宜，这样可以尽量降低使用者触碰到吸水垫的概率。
在图5所示检测装置103和图6所示检测装置104的示例中，吸水垫的下游端即支撑板1的前端不被吸水垫覆盖，该前端的材料为疏水性的材料，作为本发明所述的疏水性元件。样品垫上的待测溶液顺次流过标记结合物释放垫、反应膜到达吸水垫后，吸水垫上的样品溶液不会被疏水性的支撑板进一步吸收，因此手 捏区不会残留测试溶液。使用者捏在检测装置的手捏区上后，不用担心被感染的风险。
如图7所示的检测装置105，包括支撑板1，在支撑板1上从上游到下游依次相互叠加的粘附有样品垫2、标记结合物释放垫3、反应膜4、吸水垫5和作为疏水性元件的阻挡块8。阻挡块8的材料是疏水性的，流动至吸水垫上的样品溶液不会被阻挡块吸收。
在其他的实施例中，检测装置与图5、6、7类似，区别是吸水垫的上边沿与支撑板的上边沿对齐，在检测装置的手捏区安装一个手柄，该手柄为疏水性材料。
图6所示的检测装置是在图5的基础上，在检测装置的样品垫和标记结合物释放垫上粘贴有不干胶贴纸6，在吸水垫和部分支撑板上粘贴有不干胶贴纸6。图7所示检测装置的相应部位也可以粘贴上不干胶贴纸。
在一个优选的方案中，如图6所示，对应于手捏区的不干胶贴纸上设一个手捏区指示标记，用于提示使用者将手指捏在此处，从而进一步避免使用者拿错位置而被残存的待测溶液污染。所述的指示标记可以是图案，例如手的图案61，或者是不同于其他区域的颜色指示。
在另一个优选的方案中，为避免反应膜上残存的样品溶液接触到使用者或降低对外环境的污染，在反应膜上粘贴了一层透明的不干胶贴纸。
在一些实施例中，样品垫和标记结合物释放垫可以加工成一个垫子，选用同样的材料，例如检测装置包括支撑板，在支撑板上从上游到下游依次相互叠加的粘附有样品处理垫、反应膜和吸水垫，吸水垫5的上边沿51与支撑板1的上边沿11之间设有疏水元件，所述样品处理垫上处理有标记结合物，样品添加在样品处理垫上后，样品的被分析物与该垫上的标物结合物发生反应。
支撑板的材料选自疏水性的聚酯(PET)胶板、聚氯乙烯(PVC)胶板、聚丙烯(PP)胶板、聚碳酸酯(PC)胶板这些疏水性的材料也可以作为疏水元件的材料。
样品垫的材料选自玻璃纤维素、聚酯膜、聚酯纤维膜、无纺布、滤纸。
标记结合物释放垫材料选自玻璃纤维素、聚酯膜、聚酯纤维膜、无纺布。
反应膜的材料选自NC膜、硝酸纤维素膜。
吸水垫的材料选自纤维素滤纸、吸水纸、滤纸。
不干胶贴纸的材料选自疏水性的铜版纸、透明聚氯乙烯(PVC)、静电聚氯乙烯(PVC)、聚酯(PET)、镭射纸、耐温纸、聚丙烯(PP)、聚碳酸酯(PC)、牛皮纸、荧光纸、镀金纸、镀银纸、合成纸、铝箔纸、易碎(防伪)纸、美纹纸、布标(泰维克/尼龙)纸、珠光纸、夹心铜版纸、热敏纸。
图5所述检测装置的制备方法。提供图8所示支撑板10，支撑板1对应检测装置的疏水元件处预先粘贴了不干胶贴纸12，对应吸水垫的位置预先粘贴不干胶贴纸13，对应反应膜的位置预先粘贴不干胶贴纸14，对应样品垫和标记结合物释放垫的位置粘贴不干胶贴纸15。首先，除去不干胶贴纸14，将反应膜粘贴在去除了不干胶贴纸14的支撑板处，在反应膜的检测线41和对照线42处理上对应的检测试剂。待反应膜上的检测试剂干燥后，除去不干胶贴纸13，在此处贴上吸水垫5，吸水垫的一端与不干胶贴纸12对齐，另一端叠加粘贴在反应膜上。除去不干胶15，依次粘贴上标记结合物释放垫和样品垫，标记结合物释放垫一端与反应膜叠加，另一端与样品垫叠加。在不除去不干胶贴纸12的情况下粘贴吸水垫，吸水垫的上边沿与不干胶贴纸12的下边沿对齐，不干胶贴纸12可以起到吸水垫粘贴定位的作用。在制作完成图5所示检测装置后，不干胶贴纸12可以除去，也可以不除去。在另一个实施方式中，除去不干胶贴纸12后，在此处贴上阻挡块8，然后再除去不干胶贴纸13，吸水垫上边沿沿着阻挡块8的下边沿粘贴。阻挡块8起到粘贴吸水垫粘贴的定位作用。
如图9所示，将本发明所述检测装置装配在检测板中，所述检测板包括可相互扣合的上盖111和下板112。由于检测装置具有疏水性元件7，可以避免残留测试溶液经疏水元件慢慢渗透到检测板外。从而有效避免或降低使用者因接触残留测试溶液而被感染的风险。

Claims (10)

  1. 一种检测装置，包括支撑板，在支撑板上从上游到下游依次叠加的粘附有样品处理垫、反应膜和吸水垫，其特征在于，在检测装置的吸水垫下游端设有疏水性元件。
  2. 根据权利要求1所述的检测装置，其特征在于，疏水性元件为支撑板的前端，所述前端的材料为疏水性材料并且不被吸水垫覆盖。
  3. 根据权利要求1所述的检测装置，其特征在于，所述疏水性元件为一个阻挡块。
  4. 根据权利要求3所述的检测装置，其特征在于，阻挡块粘附在位于吸水垫下游的支撑板上。
  5. 根据权利要求1所述的检测装置，其特征在于，所述疏水性元件为手柄。
  6. 根据权利要求1至5之一所述的检测装置，其特征在于，所述样品处理垫可包括独立的样品垫和标记结合物释放垫，样品垫和标记结合物释放垫从上游到下游依次相互叠加的粘附在支撑板上。
  7. 根据权利要求6所述的检测装置，其特征在于，在样品处理垫、吸水垫上粘贴有不干胶贴纸。
  8. 根据权利要求7所述的检测装置，其特征在于，不干胶贴纸相应于疏水元件处设有手捏区指示标记。
  9. 根据权利要求1所述的检测装置，其特征在于，疏水性元件的区域大小以能满足使用者手指能拿住检测装置但又不会碰到吸水垫。
  10. 根据权利要求1所述的检测装置，其特征在于，所述检测装置装配在检测板中，所述检测板包括可相互扣合的上盖和下板。
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