WO2022180609A1 - Gel stabilized o/w emulsion with alpha-arbutin and azelaic acid dispersion - Google Patents
Gel stabilized o/w emulsion with alpha-arbutin and azelaic acid dispersion Download PDFInfo
- Publication number
- WO2022180609A1 WO2022180609A1 PCT/IB2022/051705 IB2022051705W WO2022180609A1 WO 2022180609 A1 WO2022180609 A1 WO 2022180609A1 IB 2022051705 W IB2022051705 W IB 2022051705W WO 2022180609 A1 WO2022180609 A1 WO 2022180609A1
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- WO
- WIPO (PCT)
- Prior art keywords
- skin care
- care composition
- present
- range
- anionic polymer
- Prior art date
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- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 title claims abstract description 76
- BJRNKVDFDLYUGJ-ZIQFBCGOSA-N alpha-Arbutin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-ZIQFBCGOSA-N 0.000 title claims description 10
- 229940033280 alpha-arbutin Drugs 0.000 title claims description 10
- 239000006185 dispersion Substances 0.000 title description 4
- 239000007764 o/w emulsion Substances 0.000 title description 2
- 239000000203 mixture Substances 0.000 claims abstract description 156
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims abstract description 42
- 150000001875 compounds Chemical class 0.000 claims abstract description 41
- 125000000687 hydroquinonyl group Chemical class C1(O)=C(C=C(O)C=C1)* 0.000 claims abstract description 38
- 229920006318 anionic polymer Polymers 0.000 claims abstract description 37
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims abstract description 35
- 229960003966 nicotinamide Drugs 0.000 claims abstract description 35
- 235000005152 nicotinamide Nutrition 0.000 claims abstract description 35
- 239000011570 nicotinamide Substances 0.000 claims abstract description 35
- 239000002562 thickening agent Substances 0.000 claims abstract description 24
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229940032094 squalane Drugs 0.000 claims abstract description 21
- 239000000839 emulsion Substances 0.000 claims abstract description 17
- 229920006007 hydrogenated polyisobutylene Polymers 0.000 claims abstract description 17
- 150000002148 esters Chemical class 0.000 claims abstract description 14
- 239000003921 oil Substances 0.000 claims abstract description 14
- 239000003974 emollient agent Substances 0.000 claims abstract description 13
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 13
- 229920002545 silicone oil Polymers 0.000 claims abstract description 11
- 239000003755 preservative agent Substances 0.000 claims description 24
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 19
- -1 other actives Substances 0.000 claims description 19
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 239000004480 active ingredient Substances 0.000 claims description 15
- 229920001577 copolymer Polymers 0.000 claims description 14
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 claims description 13
- 229940100554 isononyl isononanoate Drugs 0.000 claims description 13
- 239000003021 water soluble solvent Substances 0.000 claims description 12
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims description 11
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 11
- 229940104261 taurate Drugs 0.000 claims description 11
- 239000000284 extract Substances 0.000 claims description 9
- 239000003906 humectant Substances 0.000 claims description 9
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- 235000011187 glycerol Nutrition 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 6
- 239000002738 chelating agent Substances 0.000 claims description 4
- 239000003205 fragrance Substances 0.000 claims description 4
- 239000000377 silicon dioxide Substances 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 238000005191 phase separation Methods 0.000 claims description 3
- 239000000049 pigment Substances 0.000 claims description 3
- 239000013078 crystal Substances 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 208000002874 Acne Vulgaris Diseases 0.000 abstract description 5
- 206010000496 acne Diseases 0.000 abstract description 5
- 230000000887 hydrating effect Effects 0.000 abstract description 4
- 230000002757 inflammatory effect Effects 0.000 abstract description 3
- 230000003902 lesion Effects 0.000 abstract description 3
- 230000036555 skin type Effects 0.000 abstract description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 12
- 239000000463 material Substances 0.000 description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 9
- 239000000654 additive Substances 0.000 description 9
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 9
- 230000002335 preservative effect Effects 0.000 description 7
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 6
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
- 150000001298 alcohols Chemical class 0.000 description 6
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 5
- 230000002411 adverse Effects 0.000 description 5
- 125000004432 carbon atom Chemical group C* 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 229940051250 hexylene glycol Drugs 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 230000000087 stabilizing effect Effects 0.000 description 4
- 240000008067 Cucumis sativus Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 229920006037 cross link polymer Polymers 0.000 description 3
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 150000002334 glycols Chemical class 0.000 description 3
- 230000036571 hydration Effects 0.000 description 3
- 238000006703 hydration reaction Methods 0.000 description 3
- 150000007524 organic acids Chemical class 0.000 description 3
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 3
- 229920005862 polyol Polymers 0.000 description 3
- 150000003077 polyols Chemical class 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 150000003892 tartrate salts Chemical class 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
- ARXKVVRQIIOZGF-UHFFFAOYSA-N 1,2,4-butanetriol Chemical compound OCCC(O)CO ARXKVVRQIIOZGF-UHFFFAOYSA-N 0.000 description 2
- ZWVMLYRJXORSEP-UHFFFAOYSA-N 1,2,6-Hexanetriol Chemical compound OCCCCC(O)CO ZWVMLYRJXORSEP-UHFFFAOYSA-N 0.000 description 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 2
- POAOYUHQDCAZBD-UHFFFAOYSA-N 2-butoxyethanol Chemical compound CCCCOCCO POAOYUHQDCAZBD-UHFFFAOYSA-N 0.000 description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 description 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- 239000005711 Benzoic acid Substances 0.000 description 2
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 2
- 239000004287 Dehydroacetic acid Substances 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- XPJVKCRENWUEJH-UHFFFAOYSA-N Isobutylparaben Chemical compound CC(C)COC(=O)C1=CC=C(O)C=C1 XPJVKCRENWUEJH-UHFFFAOYSA-N 0.000 description 2
- 235000011430 Malus pumila Nutrition 0.000 description 2
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- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 2
- 206010039792 Seborrhoea Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229920002385 Sodium hyaluronate Polymers 0.000 description 2
- UWHCKJMYHZGTIT-UHFFFAOYSA-N Tetraethylene glycol, Natural products OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 2
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- 235000010233 benzoic acid Nutrition 0.000 description 2
- 229960004365 benzoic acid Drugs 0.000 description 2
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 2
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- DLAHAXOYRFRPFQ-UHFFFAOYSA-N dodecyl benzoate Chemical compound CCCCCCCCCCCCOC(=O)C1=CC=CC=C1 DLAHAXOYRFRPFQ-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 2
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- 238000005259 measurement Methods 0.000 description 2
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- ABEXEQSGABRUHS-UHFFFAOYSA-N 16-methylheptadecyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC(C)C ABEXEQSGABRUHS-UHFFFAOYSA-N 0.000 description 1
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- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Definitions
- the present disclosure is directed to a skin care composition that includes a high level of active ingredients including azelaic acid, hydroquinone derivative, and niacinamide for treating target skin conditions in a pleasing and stable composition.
- compositions for addressing dryness and tightness often include a high oil content with high amounts of stabilizing thickeners that can cause them to be heavy and leave a greasy skin feel.
- These compositions may include silicones and silicone oils that can be thinning and adversely affect the pleasant feel associated with a creamy hydrating formulation.
- alcohols and silicones are often used, which can be drying and irritating to skin.
- compositions that overcomes the shortcomings of the prior art and provides benefits that include delivery of hydration and high actives to address pigmentation and acne issues, in a creamy, light formulation that is creamy upon initial application to skin and breaks into a watery gel upon rubbing and does not leave the skin oily.
- the present invention provides such a composition.
- the invention provides a skin care composition that includes a high level of active ingredients including azelaic acid, at least one hydroquinone derivative, and niacinamide and at least one anionic polymer thickener to provide a temperature-stable gel stabilized emulsion type architecture that upon initial application to a keratinous tissue breaks into a watery gel upon rubbing.
- active ingredients including azelaic acid, at least one hydroquinone derivative, and niacinamide and at least one anionic polymer thickener to provide a temperature-stable gel stabilized emulsion type architecture that upon initial application to a keratinous tissue breaks into a watery gel upon rubbing.
- the combination of the active ingredients that include the azelaic acid, the at least one hydroquinone derivative, and the niacinamide are present together as a combination (the "active ingredient combination").
- the skin care composition also includes an "oily" phase components that include squalane, and one or more other fatty compounds that comprise emollient esters, for example, isononyl isononanoate, hydrogenated polyisobutene, or combinations of these.
- the skin care composition also includes in the water phase or the oily phase additional components that include one or more water-soluble solvents, humectants, other actives, preservatives, pH adjusters, chelating agents, dyes, pigments, fragrance, or any combinations of these.
- the skin care composition is free or essentially free of monoalcohols, silicones, silicone oils, and oils other than fatty compounds that comprise emollient esters, hydrogenated polyisobutene, and squalane.
- the skin care composition comprises a gel stabilized emulsion comprising: i. an active ingredient combination comprising a combination of actives that include azelaic acid present in a range from about 0.5% to about 5%, at least one hydroquinone derivative present in a range from about 0.5% to about 5%, and niacinamide present in a range from about 0.5% to about 4.0%, all based on the total weight of the skin care composition; ii. at least one anionic polymer thickener; and iii. at least one fatty compound.
- azelaic acid is present in a range from about 0.5% to about 4.5%, based on the total weight of the skin care composition. In some embodiments azelaic acid is present in a range from about 0.5% to about 3.5%. In some embodiments azelaic acid is present in a range from about 0.5% to about 3.0%. In some embodiments azelaic acid is present in a range from about 1% to about 3.5%. In some embodiments azelaic acid is present in a range from about 2.5% to about 3.5%.
- the at least one hydroquinone derivative is present in a range from about 0.5% to about 4.5%, based on the total weight of the skin care composition. In some embodiments hydroquinone derivative is present in a range from about 0.5% to about 4.0%. In some embodiments hydroquinone derivative is present in a range from about 0.5% to about 3.0%. In some embodiments hydroquinone derivative is present in a range from about 1% to about 3.0%. In some embodiments hydroquinone derivative is present in a range from about 1.5% to about 2.5%.
- the at least one hydroquinone derivative is alpha arbutin.
- niacinamide is present in a range from about 0.5% to about 3.5%, based on the total weight of the skin care composition. In some embodiments niacinamide is present in a range from about 0.5% to about 3.0%. In some embodiments niacinamide is present in a range from about 1% to about 3.5%. In some embodiments niacinamide is present in a range from about 0.5% to about 2.5%. In some embodiments niacinamide is present in a range from about 2.0% to about 3.0%.
- the at least one anionic polymer is present in a range from about 0.05% to about 3%, based on the total weight of the skin care composition. In some embodiments, each of the at least one anionic polymer is present in a range from about 0.05% to about 3%. In some embodiments, the total amount of anionic polymer is present in a range from about 0.05% to about 3%.
- the at least one anionic polymer comprises one or more of ammonium polyacryloyldimethyl taurate, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, or a combination thereof. In some embodiments the at least one anionic polymer comprises both ammonium polyacryloyldimethyl taurate, and hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.
- the at least one fatty compound is present in a range from about l%to about 15%, based on the total weight of the skin care composition. In some embodiments, each of the at least one fatty compound is present in a range from about 1% to about 15%. In some embodiments, the total amount of fatty compound is present in a range from about 1% to about 15%.
- the at least one fatty compound comprises one or more of hydrogenated polyisobutene, isononyl isononanoate, squalane, or a combination thereof.
- the at least one fatty compound comprises each of hydrogenated polyisobutene, isononyl isononanoate, and squalane.
- the skin care composition comprises a gel stabilized emulsion comprising a combination of actives that include azelaic acid, at least one hydroquinone derivative, and niacinamide; at least one anionic polymer thickener; and at least one fatty compound, wherein: i. in the combination of actives that include azelaic acid, at least one hydroquinone derivative, and niacinamide, a. azelaic acid is present in a range from about 0.5% to about 5%; b. the at least one hydroquinone derivative is present in a range from about 0.5% to about 5%; and c.
- niacinamide is present in a range from about 0.5% to about 4%; ii. the at least one anionic polymer is present in a range from about 0.05% to about 3%; and iii. the at least one fatty compound is present in a range from about 1% to about 15%, all amounts by weight based on the total weight of the skin care composition.
- the skin care composition comprises a gel stabilized emulsion comprising a combination of actives that include azelaic acid present in a range from about 0.5% to about 5%, at least one hydroquinone derivative present in a range from about 0.5% to about 5%, and niacinamide present in a range from about 0.5% to about 4.0%, all amounts by weight, based on the total weight of the skin care composition; at least one anionic polymer thickener; and at least one fatty compound, wherein: i. in the combination of actives that include azelaic acid, at least one hydroquinone derivative, and niacinamide, the at least one hydroquinone derivative is alpha arbutin; ii.
- the at least one anionic polymer comprises ammonium polyacryloyldimethyl taurate and hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer; and iii. the at least one fatty compound comprises hydrogenated polyisobutene, isononyl isononanoate, and squalane.
- the invention also provides a method for forming a skin care composition comprising a combination of actives that include azelaic acid, at least one hydroquinone derivative, and niacinamide; at least one anionic polymer thickener; and at least one fatty compound, the method comprising: providing the at least one hydroquinone derivative and niacinamide solubilized in a water phase; blending azelaic acid with the water phase; combining an oil phase with the water phase to provide an emulsion.
- cosmetically acceptable means a carrier that is compatible with any keratinous substrate.
- emulsion architecture means that the skin care composition has the properties generally associated with an oil in water emulsion.
- keratinous substrate and “keratinous tissue” each includes but is not limited to skin, hair, and nails.
- skin means and includes skin materials containing keratin such as facial and body skin, scalp, eyebrows, and lips.
- the invention provides a skin care composition that includes a high level of active ingredients including azelaic acid, at least one hydroquinone derivative, and niacinamide and at least one anionic polymer thickener to provide a temperature-stable gel stabilized emulsion type architecture that is creamy upon initial application to a keratinous tissue and breaks into a watery gel upon rubbing.
- active ingredients including azelaic acid, at least one hydroquinone derivative, and niacinamide and at least one anionic polymer thickener to provide a temperature-stable gel stabilized emulsion type architecture that is creamy upon initial application to a keratinous tissue and breaks into a watery gel upon rubbing.
- the skin care composition when applied provides the sensorial effect of creamy initial application that breaks into a watery gel upon rubbing. This provides the user with a sense of hydration without a heavy oily feeling and is well suited for users with oily skin or those that prefer a light-weight moisturizer.
- the skin care composition is an emulsion with a water phase containing the actives and any "oily-type" phase that excludes typical oils and silicone oils often found in similar types of skin care formulations.
- the "oil” phase includes of isononyl isononanoate and squalane, and anionic polymer thickeners that include ammonium polyacryloyldimethyl taurate and hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, present in a total amount of about 0.05% to about 3% and in some such embodiments, these are present at about 1.5%.
- the anionic polymer thickeners stabilize the emulsion by stabilizing the isononyl isononanoate and squalane and likewise stabilizing the azelaic acid dispersion, particularly when the azelaic acid is present in a high amount, for example, at about 3%, together with about 2.5% niacinamide and about 2% alpha-arbutin, all by weight, based on the weight of the skin care composition.
- the skin care composition also includes other active ingredients that include a blend of botanicals, such as cucumber extract, and olive leaf extract, as well as about 5% glycerin, about 3% propylene glycol, and silica silylate to produce a mattifying finish.
- active ingredients such as cucumber extract, and olive leaf extract, as well as about 5% glycerin, about 3% propylene glycol, and silica silylate to produce a mattifying finish.
- the skin care composition is optimal for users with acne-prone skin, post- inflammatory hyperpigmentation, post-inflammatory erythema, oily skin, and skin in need of hydration.
- the skin care composition demonstrates surprising benefits wherein the inventive skin care composition comprises relatively high amounts of the actives, particularly in the combination of actives that include azelaic acid, at least one hydroquinone derivative, and niacinamide, and remains stable without separation of the actives over a wide temperature range for at least two months/8 weeks.
- the skin care composition may be especially hydrating and comfortable for the wearer and is oil free, without appearing shiny or greasy on the skin, and includes actives to treat the appearance of dark spots and inflammatory lesions, including acne, for all skin types.
- stable and “stability” with respect to the emulsion architecture of the skin care composition refers to the skin care composition remaining in a creamy emulsion state and not phase separating as evidenced by the formation of significant fluid droplets.
- stable or stability may include the absence of or minimal formation of crystals. Such properties may be achieved even with the inclusion of high amounts of actives and in the absence of silicones and silicone oils. Stability is evidenced by one or both of direct measurement of viscosity, pH stability, and microscopic inspection, and by visual inspection.
- an inventive composition remains stable at temperatures in the range from about 5 °C to about 45 °C, over a time period of at least two months, and may remain stable for longer, for example for at least three months, or at least four months, or at least six months, and up to about at least 3 years, or any value, range, or sub-range therebetween.
- inventive skin care compositions shown in the examples herein demonstrated stability at each of 5 °C, 25 °C, 37 °C, and 45 °C for a period of eight weeks. And such exemplified compositions demonstrated stability for 10 freeze-thaw cycles at -20 °C /25 °C.
- the skin care composition is free or essentially free of monoalcohols, silicones, silicone oils, and oils other than fatty compounds that comprise emollient esters, hydrogenated polyisobutene, and squalane.
- the skin care composition may comprise one or more of fatty compounds that comprise emollient esters, hydrogenated polyisobutene, and squalane.
- any excluded agent is absent or if present, is present in an amount that is at or below 1%, or 0.5%, or 0.1% of such excluded agent, based on the total weight of the skin care composition.
- the skin care composition is devoid of any or all of the excluded agents.
- the skin care composition is free or essentially free of monoalcohols, for example, but not limited to, monohydric C ⁇ -C 8 alcohols selected from the group consisting of ethanol, propanol, butanol, isopropanol, isobutanol, and benzyl alcohol, and phenylethyl alcohol.
- monoalcohols for example, but not limited to, monohydric C ⁇ -C 8 alcohols selected from the group consisting of ethanol, propanol, butanol, isopropanol, isobutanol, and benzyl alcohol, and phenylethyl alcohol.
- the skin care composition is free or essentially free of silicones.
- the skin care composition is free or essentially free of silicone oils, for example, silicone oils selected from, but not limited to, the group consisting of dimethicone, dimethiconol, silicone crosspolymers, silicone copolymers, and polysiloxanes.
- the skin care composition includes, in various embodiments, a combination of the active ingredients that include azelaic acid, at least one hydroquinone derivative, and niacinamide, present together as a combination of active ingredients (the "active ingredient combination"), with at least one anionic polymer thickener.
- the active ingredient combination relative to the total amount of anionic polymer thicker is present in a ratio of about 4.5:1 wherein there is about 7.5% of the active ingredient combination and about 1.6% of the anionic polymer thicker, all weights based on the total weight of the skin care composition.
- the skin care composition also includes an "oily" phase components that include squalane, and one or more other fatty compounds that comprise emollient esters, for example, isononyl isononanoate, hydrogenated polyisobutene, or combinations of these.
- the skin care composition also includes in the water phase additional components that include one or more water-soluble solvents, humectants, other actives, preservatives, pH adjusters, chelating agents, pigments, fragrance, or any combinations of these, together with water and the at least one hydroquinone derivative, and the niacinamide.
- the skin care composition is free or essentially free of monoalcohols, silicones, silicone oils, and oils other than fatty compounds that comprise emollient esters, hydrogenated polyisobutene, and squalane.
- the skin care composition includes an active ingredient combination comprising azelaic acid, at least one hydroquinone derivative, and niacinamide.
- the hydroquinone derivative is alpha arbutin.
- the azelaic acid is present in the skin care composition in a range from about 0.5% to about 5% by weight, based on the weight of the skin care composition, or from about 0.5% to about 4.5%, or from about 0.5% to about 3.5%, or from about 0.5% to about 3.0%, or from about 1% to about 3.5%, or from about 1.0% to about 3.5%, or from about 2.5% to about 3.5%, or from about 0.75% to about 1%, or from about 0.5% to about 2.5%, or from about 0.5% to about 0.75%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the skin care composition.
- ranges are within the scope of the invention.
- the azelaic acid is present in the skin care composition, by weight, based on the total weight of the skin care composition, from about 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3.0, 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, 4.0, 4.1, 4.2, 4.3, 4.4, 4.5, 4.6, 4.7, 4.8, 4.9 to about 5.0 percent, including increments and ranges therein and there between.
- the at least one hydroquinone derivative is present in the skin care composition in a range from about 0.5% to about 5% by weight, based on the weight of the skin care composition, or from about 0.5% to about 4.5%, or from about 0.5% to about 4.0%, or from about 0.5% to about 3.0%, or from about 1% to about 3.0%, or from about 1.5% to about 2.5%, or from about 1.0% to about 3.5%, or from about 1.0% to about 3.0%, or from about 2.5% to about 3.5%, or from about 0.75% to about 1%, or from about 0.5% to about 2.5%, or from about 0.5% to about 0.75%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the skin care composition.
- ranges are within the scope of the invention.
- the at least one hydroquinone derivative is present in the skin care composition, by weight, based on the total weight of the skin care composition, from about 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3.0, 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, 4.0, 4.1, 4.2, 4.3, 4.4, 4.5, 4.6, 4.7, 4.8, 4.9 to about 5.0 percent, including increments and ranges therein and there between.
- niacinamide is present in the skin care composition in a range from about 0.5% to about 4% by weight, based on the weight of the skin care composition, or from about 0.5% to about 3.5%, or from about 0.5% to about 3.0%, or from about 1% to about 3.5%, or from about 0.5% to about 2.5%, or from about 2.0% to about 3.0%, or from about 2.5% to about 3.5%, or from about 0.75% to about 1%, or from about 0.5% to about 2.5%, or from about 0.5% to about 0.75%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the skin care composition.
- ranges are within the scope of the invention.
- niacinamide is present in the skin care composition, by weight, based on the total weight of the skin care composition, from about 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3.0, 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, to about 4.0 percent, including increments and ranges therein and there between.
- the skin care composition includes at least one anionic polymer thickener.
- the at least one anionic polymer thickener may be selected from, for example, ammonium polyacryloyldimethyl taurate copolymer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, or a combination thereof.
- the skin care composition includes at least two anionic polymer thickeners.
- suitable anionic polymer thickeners include at least one of a thickener selected from xanthan gum, cellulose gum, acrylate crosspolymers, acrylate copolymers, sodium polyacrylate, poly acrylate cross polymers, or a combination thereof.
- each anionic polymer thickener is present in the skin care composition in an amount from about 0.05% to about 3%, or from about 0.075% to about 1%, or from about 0.5% to about 2.5%, or from about 0.5% to about 0.75%, or from about 0.1% to about 0.2%, or from about 1% to about 1.5%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the skin care composition.
- the total amount of thickener present in the skin care composition in an amount from about 0.05% to about 3%, or any suitable combination, sub combination, range, or sub-range thereof by weight, based on the weight of the skin care composition.
- the skin care composition includes at least two anionic polymer thickeners, comprising, for example, each of ammonium polyacryloyldimethyl taurate copolymer and hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, each present in a range from about 0.05% to about 3%, or as combined in a range from about 0.05% to about 3%, and in some particular embodiments the total amount is about 1.5% to about 1.75% .
- anionic polymer thickeners comprising, for example, each of ammonium polyacryloyldimethyl taurate copolymer and hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, each present in a range from about 0.05% to about 3%, or as combined in a range from about 0.05% to about 3%, and in some particular embodiments the total amount is about 1.5% to about 1.75% .
- the at least one anionic polymer thickener is present by weight, based on the total weight of the skin care composition, from about 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, to about 3.0 percent, including increments and ranges therein and there between.
- the skin care composition includes at least one fatty compound selected from emollient esters, hydrogenated polyisobutene, and squalane. In some embodiments, the skin care composition comprises more than one fatty compound. In some particular embodiments, the skin care composition includes a combination of fatty compounds comprising hydrogenated polyisobutene, isononyl isononanoate, and squalane.
- the at least one fatty compound is an emollient ester, which has a carbon chain length of C12 to C24. In some embodiments, the at least one emollient ester is an alkylated alcohol ester.
- the at least one emollient ester has a formula RCOOR' in which R represents a linear or branched fatty acid residue containing from 1 to 40 carbon atoms and R' represents a hydrocarbon-based chain that is especially branched, containing from 1 to 40 carbon atoms on condition that R+R' is y 10, for instance Purcellin oil (cetearyl octanoate), isopropyl myristate, isopropyl palmitate, C12-C15 alkyl benzoate, such as the product sold under the trade name Finsolv TN ® or Witconol TN ® by Witco or Tegosoft TN ® by Evonik Goldschmidt, 2-ethylphenyl benzoate, such as the commercial product sold under the name X-Tend 226 by ISP, isopropyl lanolate, hexyl laurate, diisopropyl adipate, isononyl isononano
- the at least one fatty compound is present from about 1% to about 15% by weight of the skin care composition, and in some embodiments, from about 1% to about 10%, and in some embodiments, from about 1% to about 7%, and in some embodiments, from about 2% to about 5%, and in some embodiments, about 5% or about 2%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the skin care composition.
- the skin care composition comprises more than one fatty compound, the combination thereof present in the skin care composition at a concentration, from about 1% to about 20%, and each of the more than one present in the skin care composition at a concentration from about 1% to about 15%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the skin care composition.
- fatty compound the combination thereof present in the skin care composition at a concentration, from about 1% to about 20%
- each of the more than one present in the skin care composition at a concentration from about 1% to about 15%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the skin care composition.
- each one or a combination of the at least one fatty compound is present in a composition according to the disclosure from about 1, 2, 3, 4, 5, 6, 7, 8, 9,10, 11, 12, 13, 14, to about 15 percent, by weight, including increments and ranges therein and there between.
- the skin care composition includes water, by weight, in an amount from about 20% to about 90%, or about 30% to about 80%, or about 40% to about 70%, or any value, range, or sub-range therebetween.
- water by weight, in an amount from about 20% to about 90%, or about 30% to about 80%, or about 40% to about 70%, or any value, range, or sub-range therebetween.
- any water is present, by weight, based on the total weight of the skin care composition, from about 20, 21, 22, 23, 23, 25, 26, 27, 28, 29, 30, 31, 32 ,33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, to about 50 weight percent, including increments and ranges therein and there between.
- the skin care composition may include one or more water-soluble solvent.
- water-soluble solvent is interchangeable with the term “water-miscible solvent” and means a compound that is liquid at 25 °C and at atmospheric pressure (760 mmHg), and it has a solubility of at least 50% in water under these conditions. In some cases, the water-soluble solvent has a solubility of at least 60%, 70%, 80%, or 90% in water under these conditions.
- Non-limiting examples of water-soluble solvents include, for example, glycerin, alcohols (for example, C1-C30, C1-C15, C1-C10, or C1-C4 alcohols), polyols, glycols, and combinations thereof.
- water-soluble solvents examples include ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, propane diol, and glycerin.
- the organic solvents can be volatile or non-volatile compounds.
- water-soluble solvents include alkanols (polyhydric alcohols such as glycols and polyols) such as glycerin, 1,2,6-hexanetriol, trimethylolpropane, ethylene glycol, propylene glycol, diethylene glycol, butylene glycol, hexylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol, dipropylene glycol, 1,3-butanediol, 2,3-butanediol, 1,4-butanediol, 3-methyl-l,3-butanediol, 1,5- pentanediol, tetraethylene glycol, 1,6-hexanediol, 2-methyl-2,4-pentanediol, polyethylene glycol, 1,2,4-butanetriol, 1,2,6-hexanetriol, 2-butene-l,4-diol, 2-ethyl
- the total amount of the water-soluble solvent, when present, is present from about 0.5% to about 25%, or from about 0.5% to about 20%, or from about 1% to about 20%, or from about 1% to about 10%, or from about 2% to about 5% or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the skin care composition.
- the total amount of the water-soluble solvent when present, is present from about 0.5% to about 25%, or from about 0.5% to about 20%, or from about 1% to about 20%, or from about 1% to about 10%, or from about 2% to about 5% or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the skin care composition.
- any one water-soluble solvent when present, is present, by weight, based on the total weight of the skin care composition, from about 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24 to about 25 weight percent, including increments and ranges therein and there between.
- the humectant may comprise one or more of polyols, including, for example, glycerin, glycerol, glycols, such as, caprylyl glycol, butylene glycol, propylene glycol, isoprene glycol, dipropylene glycol, hexylene glycol and polyethylene glycols, monoethylene glycol, diethylene glycol, triethylene glycol, diethylene glycol, hexylene glycol, glycol ethers, such as, monopropylene, dipropylene and tripropylene glycol alkyl(Cl-C4)ethers, squalane, triacetin, sugars, such as, glucose, xylitol, maltitol, sorbitol, sucrose pentaerythritol, inositol, pyrrolidone carboxylic acid,
- polyols including, for example, glycerin, glycerol, glycols, such as, capryly
- the amount of humectant present in the skin care composition can range from about 1% to about 10%, or from about 1% to about 8%, or from about 1% to about 5%, or from about 2% to about 3%, or any suitable combination, sub combination, range, or sub-range thereof by weight, based on the weight of the skin care composition.
- humectant present in the skin care composition.
- any one of or a combination of humectant, when present, may be present, by weight, based on the total weight of the skin care composition, is from about 1, 2, 3, 4, 5, 6, 7, 8, 9, to about 10 weight percent, including increments and ranges therein and there between.
- any humectants are present only to the extent and in amounts that do not materially adversely affect the basic and novel characteristic(s) of the claimed disclosure.
- one or more preservatives and/or antimicrobials may be present in the skin care composition.
- Any preservative commonly used in cosmetic skin care compositions is an acceptable preservative for the skin care compositions herein, such as phenoxyethanol, members from the paraben family such as the methyl, ethyl, propyl, butyl or isobutyl parabens, 4-hydroxy benzoic acid, benzoic acid, sorbic acid, dehydroacetic acid, triclosan, benzyl alcohol, chlorophenesin, or salicylic acid, for example.
- suitable solvents for optional additives in particular, suitable solvents for antimicrobials and preservatives, members from the paraben family may be used as a preservative.
- the preservative may comprise one or more of preservatives selected from the group consisting of organic acids, parabens, formaldehyde donors, phenol derivatives, quaternary ammoniums, alcohols, isothiazolinones, and combinations thereof.
- Preservatives having antibacterial activity are optionally present in the skin care compositions of the present invention.
- organic acid preservatives include, but are not limited to, sodium benzoate, potassium sorbate, benzoic acid and dehydroacetic acid, sorbic acid, and combinations thereof.
- a preferred organic acid preservative system includes a mixture of sodium benzoate and potassium sorbate.
- paraben preservatives include, but are not limited to, alkyl para-hydroxybenzoates, wherein the alkyl radical has from 1, 2, 3, 4, 5 or 6 carbon atoms and for example, from 1 to 4 carbon atoms e.g., methyl para-hydroxybenzoate (methylparaben), ethyl para-hydroxybenzoate (ethylparaben), propyl para-hydroxybenzoate (propylparaben), butyl para-hydroxybenzoate (butylparaben) and isobutyl para hydroxybenzoate (isobutylparaben).
- alkyl para-hydroxybenzoates wherein the alkyl radical has from 1, 2, 3, 4, 5 or 6 carbon atoms and for example, from 1 to 4 carbon atoms e.g., methyl para-hydroxybenzoate (methylparaben), ethyl para-hydroxybenzoate (ethylparaben), propyl para-hydroxybenzoate (propylparaben), but
- formaldehyde donor preservatives include, but are not limited to, l,3-Dimethylol-5,5-dimethylhydantoin (DMDM hydantoin), imidazolidinyl urea, gluteraldehyde, and combinations thereof.
- quaternary ammonium preservatives include, but are not limited to, benzalkonium chloride, methene ammonium chloride, benzethonium chloride, and combinations thereof.
- alcohol preservatives include, but are not limited to, ethanol, benzyl alcohol, dichlorobenzyl alcohol, phenoxyethanol, and combinations thereof.
- isothiazolone preservatives include, but are not limited to, methylchloroisothiazolinone, methylisothiazolinone, and combinations thereof.
- the preservative includes one or more preservatives, the one or combination present at a concentration, by weight of about 0.001% to about 5%, or alternatively about 0.05% to about 2.5% or alternatively about 0.1% to about 2.0%, based upon weight of the skin care composition.
- concentration by weight of about 0.001% to about 5%, or alternatively about 0.05% to about 2.5% or alternatively about 0.1% to about 2.0%, based upon weight of the skin care composition.
- any one of or a combination of preservatives, when present, may be present, by weight, based on the total weight of the skin care composition, is from about 0.001, 0.002, 0.003 ,0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.01, 0.02, 0.03 ,0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 3, 4, to about 5 weight percent, including increments and ranges therein and there between.
- a skin care composition includes at least one additive used in the cosmetics field which does not affect the properties of the skin care composition according to the invention, such as, other actives, for example, sodium hyaluronate or hyaluronic acid, hydroxyacetophenone and other antioxidants, fragrances, chelating agents, pH adjusters (citric acid, sodium chloride; neutralizing or pH-adjusting agents (e.g., triethylamine (TEA) and sodium hydroxide), and combinations thereof), other cosmetically acceptable additives, such as but not limited to, pearlescent agents, silica silylate, dyes, and coloring materials; essential oils; fruit extracts, for example, cucumis sativus fruit extract, Rosmarinus Officinalis leaf extract, Citrus Grandis fruit extract, Thymus Vulgaris flower/leaf extract, Morus Alba root extract, Olea Europaea leaf extract, Pyrus Malus (Apple) Fruit Extract, and Aloe Barbadensis Leaf Juice Powder
- other actives for example,
- the amount of one or more additives, alone or in combination, present in the skin care composition can be present in the skin care composition according to the disclosure in a range from about 0.001% to about 20%, by weight, or from about 0.005% to about 0.01%, or from about 0.01% to about 0.1%, or from about 0.15% to about 5%, or from about 0.40% to about 4%, or from about 0.5% to about 2.5% by weight, or from about 1% to about 2%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the total weight of the skin care composition.
- One of ordinary skill in the art will appreciate that other ranges are within the scope of the invention.
- any one or a combination of additives may be present, by weight, based on the total weight of the skin care composition, each one or the combination present from about 0.001, 0.002, 0.003, 0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80, 0.90, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 to about 20 weight percent, including increments and ranges therein and there between.
- any optional additives are present only to the extent and in amounts that do not materially adversely affect the basic and novel characteristic(s) of the claimed disclosure.
- TABLE 1 lists the ingredients of two embodiments of the Inventive skin care composition. [0090] TABLE 1
- the skin care composition includes about 3% azelaic acid, together with about 2.5% niacinamide and about 2% alpha-arbutin, anionic polymer that includes both ammonium polyacryloyldimethyl taurate, and hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer present in a total amount of about 1.6% the ammonium polyacryloyldimethyl taurate present in a range from about 0.05% to about 0.2% and the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer present from about 1.2% to about 1.5%, at least one fatty compound including polyisobutene present from about 0.8% to about 1%, isononyl isononanoate present from about 3.5% to about 4%, squalane present from about 1.5% to about 2%, all by weight based on the weight of the skin care composition, and also including other active ingredients that include hydroxyace
- compositions according to the formulae shown in Example 1 were evaluated for stability. Each of the inventive compositions demonstrated stability including no phase separation.
- At least one means one or more and thus includes individual components as well as mixtures/combinations.
- the terms “free” and “devoid” indicates that no reliably measurable excluded material is present in the skin care composition, typically 0% by weight, based on the total weight of the skin care composition.
- the term “essentially free” means that, while it prefers that no excluded material is present in the skin care composition, it is possible to have very small amounts of the excluded material in the skin care composition of the invention, provided that these amounts do not materially affect the advantageous properties of the skin care composition.
- "essentially free” means that excluded material can be present in the skin care composition at an amount of less than about 0.1% by weight, based on the total weight of the skin care composition.
- weight percent of an ingredient refers to the amount of the raw material comprising the ingredient, wherein the raw material may be described herein to comprise less than and up to 100% activity of the ingredient. Therefore, weight percent of an active in a composition is represented as the amount of raw material containing the active that is used and may or may not reflect the final percentage of the active, wherein the final percentage of the active is dependent on the weight percent of active in the raw material.
Abstract
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EP22706931.7A EP4312963A1 (en) | 2021-02-26 | 2022-02-25 | Gel stabilized o/w emulsion with alpha-arbutin and azelaic acid dispersion |
CN202280009103.7A CN116669697A (en) | 2021-02-26 | 2022-02-25 | Gel-stabilized O/W emulsion with alphA-Arbutin and azelaic acid dispersion |
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US17/187,084 US20220273543A1 (en) | 2021-02-26 | 2021-02-26 | Gel stabilized o/w emulsion with alpha-arbutin and azelaic acid dispersion |
US17/187,084 | 2021-02-26 | ||
FRFR2104188 | 2021-04-22 | ||
FR2104188A FR3122090B1 (en) | 2021-04-22 | 2021-04-22 | GEL-STABILIZED O/W EMULSION WITH ALPHA-ARBUTIN AND AZELAIC ACID DISPERSION |
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CN108113920A (en) * | 2017-06-21 | 2018-06-05 | 曲平波 | A kind of sustained release compound moisturizing face cream matrix of whitening and its preparation method and application |
US20180271760A1 (en) * | 2017-03-24 | 2018-09-27 | Jamie Nicole Baca | Skin Care Compositions |
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US20180271760A1 (en) * | 2017-03-24 | 2018-09-27 | Jamie Nicole Baca | Skin Care Compositions |
CN108113920A (en) * | 2017-06-21 | 2018-06-05 | 曲平波 | A kind of sustained release compound moisturizing face cream matrix of whitening and its preparation method and application |
Non-Patent Citations (1)
Title |
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LABORATOIRES FILORGA: "Meso-White Flash Whitening", GNPD, 1 September 2009 (2009-09-01), XP002751961 * |
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