WO2022175956A1 - Production d'une substance radioactive pour une capsule d'imagerie intra-lumière - Google Patents
Production d'une substance radioactive pour une capsule d'imagerie intra-lumière Download PDFInfo
- Publication number
- WO2022175956A1 WO2022175956A1 PCT/IL2022/050196 IL2022050196W WO2022175956A1 WO 2022175956 A1 WO2022175956 A1 WO 2022175956A1 IL 2022050196 W IL2022050196 W IL 2022050196W WO 2022175956 A1 WO2022175956 A1 WO 2022175956A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- canister
- radiation source
- imaging capsule
- radiation
- initial substance
- Prior art date
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 48
- 238000003384 imaging method Methods 0.000 title claims abstract description 47
- 239000000941 radioactive substance Substances 0.000 title description 34
- 230000005855 radiation Effects 0.000 claims abstract description 66
- 238000000034 method Methods 0.000 claims abstract description 47
- 239000000126 substance Substances 0.000 claims abstract description 39
- 230000004907 flux Effects 0.000 claims abstract description 15
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims abstract description 12
- 229910052805 deuterium Inorganic materials 0.000 claims abstract description 12
- 230000002285 radioactive effect Effects 0.000 claims abstract description 11
- 239000010931 gold Substances 0.000 claims description 57
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 30
- 229910052753 mercury Inorganic materials 0.000 claims description 30
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims description 28
- 229910052737 gold Inorganic materials 0.000 claims description 25
- 229920000247 superabsorbent polymer Polymers 0.000 claims description 19
- 239000007788 liquid Substances 0.000 claims description 14
- 238000001311 chemical methods and process Methods 0.000 claims description 11
- 239000000843 powder Substances 0.000 claims description 11
- 150000001875 compounds Chemical class 0.000 claims description 8
- 239000002250 absorbent Substances 0.000 claims description 7
- 230000002745 absorbent Effects 0.000 claims description 7
- 239000000853 adhesive Substances 0.000 claims description 6
- 230000001070 adhesive effect Effects 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 description 13
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 10
- 229910017604 nitric acid Inorganic materials 0.000 description 10
- 239000002245 particle Substances 0.000 description 10
- 230000000694 effects Effects 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
- 229940100892 mercury compound Drugs 0.000 description 7
- 150000002731 mercury compounds Chemical class 0.000 description 7
- 239000010453 quartz Substances 0.000 description 7
- 238000010586 diagram Methods 0.000 description 6
- 239000012857 radioactive material Substances 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- 238000001994 activation Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 229910001987 mercury nitrate Inorganic materials 0.000 description 5
- DRXYRSRECMWYAV-UHFFFAOYSA-N nitrooxymercury Chemical compound [Hg+].[O-][N+]([O-])=O DRXYRSRECMWYAV-UHFFFAOYSA-N 0.000 description 5
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 229910052782 aluminium Inorganic materials 0.000 description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 4
- 239000004568 cement Substances 0.000 description 4
- 239000002872 contrast media Substances 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- 239000003292 glue Substances 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 239000000460 chlorine Substances 0.000 description 3
- 229910052801 chlorine Inorganic materials 0.000 description 3
- 238000004587 chromatography analysis Methods 0.000 description 3
- 239000011888 foil Substances 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- ZVUZTTDXWACDHD-UHFFFAOYSA-N gold(3+);trinitrate Chemical compound [Au+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O ZVUZTTDXWACDHD-UHFFFAOYSA-N 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 241000167880 Hirundinidae Species 0.000 description 2
- 208000037062 Polyps Diseases 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 231100001261 hazardous Toxicity 0.000 description 2
- 239000003999 initiator Substances 0.000 description 2
- BQPIGGFYSBELGY-UHFFFAOYSA-N mercury(2+) Chemical compound [Hg+2] BQPIGGFYSBELGY-UHFFFAOYSA-N 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 239000012780 transparent material Substances 0.000 description 2
- 238000004876 x-ray fluorescence Methods 0.000 description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- 229920002785 Croscarmellose sodium Polymers 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- KZNMRPQBBZBTSW-UHFFFAOYSA-N [Au]=O Chemical compound [Au]=O KZNMRPQBBZBTSW-UHFFFAOYSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- QZPSXPBJTPJTSZ-UHFFFAOYSA-N aqua regia Chemical compound Cl.O[N+]([O-])=O QZPSXPBJTPJTSZ-UHFFFAOYSA-N 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 229920003020 cross-linked polyethylene Polymers 0.000 description 1
- 239000004703 cross-linked polyethylene Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 239000001064 degrader Substances 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000003818 flash chromatography Methods 0.000 description 1
- 229910001922 gold oxide Inorganic materials 0.000 description 1
- PCHJSUWPFVWCPO-YPZZEJLDSA-N gold-195 Chemical compound [195Au] PCHJSUWPFVWCPO-YPZZEJLDSA-N 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- GKOZUEZYRPOHIO-OUBTZVSYSA-N iridium-193 Chemical compound [193Ir] GKOZUEZYRPOHIO-OUBTZVSYSA-N 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 150000002730 mercury Chemical class 0.000 description 1
- 238000001471 micro-filtration Methods 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- BASFCYQUMIYNBI-IGMARMGPSA-N platinum-195 Chemical compound [195Pt] BASFCYQUMIYNBI-IGMARMGPSA-N 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 150000003839 salts Chemical group 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 239000002594 sorbent Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 239000013077 target material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G4/00—Radioactive sources
- G21G4/04—Radioactive sources other than neutron sources
- G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
- G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/40—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for generating radiation specially adapted for radiation diagnosis
- A61B6/4057—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for generating radiation specially adapted for radiation diagnosis by using radiation sources located in the interior of the body
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
Abstract
La présente invention concerne un procédé de préparation d'une substance de rayonnement destinée à libérer le rayonnement d'une capsule d'imagerie intra-lumière, comprenant : le bombardement d'une substance initiale avec un flux de neutrons, des noyaux de protons, des noyaux de deutérium ou des électrons, la production de produits comprenant un ou plusieurs isotopes et/ou isomères dont certains sont radioactifs avec une demi-vie supérieure à 48 heures, la collecte d'au moins l'un des produits dudit bombardement pour servir de source de rayonnement d'une capsule d'imagerie, l'introduction de la source de rayonnement dans une cartouche configurée pour s'adapter à une capsule d'imagerie qui peut être avalée par un utilisateur.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163151724P | 2021-02-21 | 2021-02-21 | |
| US63/151,724 | 2021-02-21 | ||
| US202163195717P | 2021-06-02 | 2021-06-02 | |
| US63/195,717 | 2021-06-02 | ||
| US202163286163P | 2021-12-06 | 2021-12-06 | |
| US63/286,163 | 2021-12-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2022175956A1 true WO2022175956A1 (fr) | 2022-08-25 |
Family
ID=82931487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IL2022/050196 WO2022175956A1 (fr) | 2021-02-21 | 2022-02-20 | Production d'une substance radioactive pour une capsule d'imagerie intra-lumière |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2022175956A1 (fr) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4532021A (en) * | 1983-07-18 | 1985-07-30 | Desoto, Inc. | Adherent ultraviolet cured coatings |
| SU1717197A1 (ru) * | 1988-01-20 | 1992-03-07 | Невинномысский Республиканский Электромеханический Завод | Способ обогащени изотопов |
| CA2380131A1 (fr) * | 2000-05-31 | 2001-12-06 | Owens Corning | Enduits super-absorbants durcissables aux ultraviolets |
| US20090162278A1 (en) * | 2005-01-14 | 2009-06-25 | Helge Leif Ravn | Method for Production of Radioisotope Preparations and Their Use in Life Science, Research, Medical Application and Industry |
| EP2476649A2 (fr) * | 2009-09-09 | 2012-07-18 | Consejo Superior de Investigaciones Cientificas (CSIC) | Procédé de stabilisation de mercure liquide au moyen de ciment polymère de soufre, à l'aide de sulfure de mercure |
| DE102011106880A1 (de) * | 2011-07-07 | 2013-01-24 | Clemens Wett | Bauplan für ein Elementsynthese |
| US20160324492A1 (en) * | 2014-02-05 | 2016-11-10 | Check-Cap Ltd. | Radiation source for intra-lumen imaging capsule |
-
2022
- 2022-02-20 WO PCT/IL2022/050196 patent/WO2022175956A1/fr active Application Filing
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4532021A (en) * | 1983-07-18 | 1985-07-30 | Desoto, Inc. | Adherent ultraviolet cured coatings |
| SU1717197A1 (ru) * | 1988-01-20 | 1992-03-07 | Невинномысский Республиканский Электромеханический Завод | Способ обогащени изотопов |
| CA2380131A1 (fr) * | 2000-05-31 | 2001-12-06 | Owens Corning | Enduits super-absorbants durcissables aux ultraviolets |
| US20090162278A1 (en) * | 2005-01-14 | 2009-06-25 | Helge Leif Ravn | Method for Production of Radioisotope Preparations and Their Use in Life Science, Research, Medical Application and Industry |
| EP2476649A2 (fr) * | 2009-09-09 | 2012-07-18 | Consejo Superior de Investigaciones Cientificas (CSIC) | Procédé de stabilisation de mercure liquide au moyen de ciment polymère de soufre, à l'aide de sulfure de mercure |
| DE102011106880A1 (de) * | 2011-07-07 | 2013-01-24 | Clemens Wett | Bauplan für ein Elementsynthese |
| US20160324492A1 (en) * | 2014-02-05 | 2016-11-10 | Check-Cap Ltd. | Radiation source for intra-lumen imaging capsule |
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