WO2022172517A1

WO2022172517A1 - System including weighing mixer

Info

Publication number: WO2022172517A1
Application number: PCT/JP2021/039583
Authority: WO
Inventors: 善郎水野; 一樹前田
Original assignee: 善郎水野; 一樹前田
Priority date: 2021-02-15
Filing date: 2021-10-27
Publication date: 2022-08-18
Also published as: JP6969764B1; JP2022123992A

Abstract

The present invention addresses the problem of providing a weighing mix system that is capable of generating a final mixture having a desired blend, by using a plurality of stick intermediates in which an active component has been homogeneously produced ahead of time over a specific length, measuring a separation length, and acquiring and mixing a necessary quantity of the active component via a simple operation for separating the stick intermediates of said length.　A system is employed that includes a weighing mixer that generates the final mixture having the desired blend, by using the plurality of types of stick intermediates, which were produced by mixing a necessary additive into the active component and are such that the active component is homogeneous over the specific length, so as to measure, cut, and separate individual lengths for the stick intermediates.

Description

A system including a metering mixer

The present invention relates to systems including meter mixers that produce final blends of intended formulations, particularly systems including meter mixers using stick intermediates.

Conventionally, when producing a mixture from a plurality of types of materials, it was common to measure the amount of each material by measuring the weight of each material. Weighing a portion by weight measurement is a complicated task that requires a skilled technique to operate a weighing device.
In conventional dispensing or self-adjustment, there was scoring to divide the length or position provided at the time of manufacture, such as 1/2, 1/4, according to the dividing line previously provided on the tablet. It was a system that could not be divided in the length or position of . In the case of dividing by a length or a position other than the dividing line provided in advance, a very sophisticated and complicated work is required to measure the amount accurately.

Patent Literature 1 describes a technique for measuring doses by using a large amount of small granular material and varying the volume to be administered.
This is a technique for a dosing device having an adjustment device for setting the volume of the dosing chamber. The dosing device is characterized in one way by a dosing unit having at least one movably mounted adjustment element that can be moved back and forth parallel to the axis of rotation by a drive to vary the volume of said dosing chamber. .

As a result of the arrangement between the transfer openings and the substantially horizontal alignment of the axis of rotation, it is possible in a simple manner to guide the adjusting device for varying the volume in the dosing chamber, independently of the position of the chamber. It is stated that it is possible to keep the administration device compact.

However, when focusing on the metering and mixing function, a dosing chamber for containing irregularly shaped small granular formulations is required, and an adjusting device for changing the volume in the dosing chamber is required for metering. It was something to do.

Japanese Patent Publication No. 2006-526629

The object of the present invention is to prepare the final mixture of the intended formulation by measuring the length corresponding to the required amount by using a plurality of stick intermediates in which the active ingredient per length is uniformly produced in advance, and measuring the length. To provide a system including a weighing mixer capable of producing a required amount of active ingredients by weighing and mixing them with a simple operation of cutting and separating a stick intermediate.
Here, the stick intermediate is formed by mixing a predetermined active ingredient and necessary additives into a rod shape in which the active ingredient per unit length is uniform. A term used to refer to materials used in intermediate processes before production.

In the first aspect of the present invention, a stick intermediate manufacturer mixes additives necessary for the active ingredient in advance to produce a rod having a predetermined diameter or cross-sectional area, and a plurality of sticks having a uniform active ingredient per length. A system for dispensing or self-regulating drugs required for drug therapy using a variety of stick intermediates, wherein individual said stick intermediates are weighed by measuring the length and cut apart to achieve the intended A system is provided that includes a metering mixer that produces a final blend of formulations.
Here, the plurality of types of intermediate sticks may include intermediate sticks having the same type of active ingredient but different cross-sectional areas or uniform concentrations.
Furthermore, the shape of the non-use end portion (hereinafter referred to as the rear end portion) of the intermediate stick may be changed according to the type or size of the active ingredient. Changes in the shape that characterizes the rear end of the stick intermediate, such as the length of the rear end, cross-sectional shape, and cross-sectional area, make the intermediate stick more identifiable and remove the intermediate stick. mistakes can be prevented.

Here, the additive may be at least one selected from base solvents, binders, lubricants, and pH adjusters.

The intermediate stick may be coated.

The system may further include a magazine capable of storing a plurality of the intermediate sticks, which is used for supplying and distributing the intermediate sticks.
Including the magazine in the system facilitates handling in the supply and distribution of intermediate sticks, as well as facilitates quality assurance.

In the above system, a) tableting means for mixing necessary additives after producing the final mixture and tableting, b) after producing the final mixture, mixing necessary additives to form a liquid It may further include at least one selected from: liquid generating means for generating; c) packaging means for packaging the final mixture after generating the final mixture.

The weighing and mixing machine may be capable of using a stick intermediate having a cross-sectional area increased or decreased by changing the cross-sectional diameter or the like according to the required amount of the raw material to be the active ingredient.

The system may include an automated dispensing machine adapted to an individual's medication regimen, wherein the metering and mixing machine is incorporated into the automated dispensing machine.

The system may be a system for blending cooking spices.

The system may be a system used for weighing and mixing raw materials in a factory manufacturing process.

The system may be a system used for weighing and mixing raw materials in at least one of personalized cosmetics, quasi-drugs or perfume refining, paint color production.

FIG. 1 is a schematic diagram showing the hardware configuration of the system of this embodiment. FIG. 2 is a schematic diagram of a stick intermediate and a magazine used in the metering mixer of this embodiment. FIG. 3 is a flow chart showing the stick intermediate production process of the present embodiment. FIG. 4 is a schematic diagram showing the main configuration of the weighing mixer of this embodiment. FIG. 5 is a schematic diagram showing the main configuration of the tablet press of this embodiment. FIG. 6 is a schematic diagram showing the main configuration of the liquid generator of this embodiment. FIG. 7 is a schematic diagram showing the main configuration of the packaging machine of this embodiment. FIG. 8 is a schematic side see-through view showing the main configuration of the dispensing machine of this embodiment. FIG. 9 is an image diagram showing a state in which the final mixture produced by the metering mixer of this embodiment is discharged into the cylinder. FIG. 10 is an image diagram showing how the final mixture in the cylinder is dispensed by pushing out the plunger rod.

For the purpose of providing a system that can accurately produce the final mixture of the intended combination with simple operation, multiple stick intermediates in which the active ingredients per length are uniformly manufactured are used. It was realized by a system including a weighing mixer equipped with a function to measure the length to separate the body and separate the stick intermediate for that length.

(system configuration diagram)
FIG. 1 is a schematic diagram showing the hardware configuration included in the system of this embodiment. Although this embodiment applies the system of the present invention to dispensing work or self-regulation, the application of the present invention is not limited to this. For example, it can be applied to a system used for weighing and mixing raw materials in refining cosmetics, quasi-drugs, or perfumes, or producing paint colors. It can also be applied to a system for blending cooking spices. Furthermore, the scale of the system is applicable from a compact system for personal use to a factory production process.

Continuing with the description of the features included in this embodiment. It is composed of

magazines

1001a, 1001b and 1001c for storing different types of intermediate sticks, a weighing mixer 1003, a tableting machine 1010, a liquid generator 1011 and a packaging machine 1012.

Three types of stick intermediates are used by the weigh mixer 1003, here

stick intermediates

1002a, 1002b, 1002c. A linear actuator that interlocks with the rotation of

dials

1004a, 1004b, and 1004c by the user linearly moves the intermediate stick whose tip is aligned with the cutting position.

The length to be cut and separated from each of the intermediate sticks is measured from the initial position and the amount of linear movement of the intermediate sticks, and displayed on the

display portions

1005a, 1005b, 1005c corresponding to the

intermediate sticks

1002a, 1002b, 1002c. be.

After completing the linear movement to the position where the desired length is cut, the user presses the cut button 1006 . Intermediate sticks of the desired length are cut and separated by the cutter of the cutting and separating section, which operates in conjunction with the depression of the cutting button. The cutting/separating portion will be described later with reference to FIG.

The cut and separated intermediate sticks are collected and mixed by a collection/mixing unit 1007 . Then, it is homogenized in a homogenization section 1008 to produce a final mixture 1009 .

The produced final mixture 1009 is supplied to a tableting machine 1010 to be tableted, supplied to a liquid generator 1011 to be liquefied, and supplied to a packaging machine 1012 to be packaged. is constructed.

Here, three types of stick intermediates are used, but the types of stick intermediates that can be employed in the present invention are not limited to these, and can be changed as appropriate according to the desired final mixture composition. can be
In addition, the weighing and mixing machine and at least one selected from a tableting machine, a liquid generator, and a packaging machine are configured as an automatic dispensing machine, and control is performed by inputting a dispensing recipe in advance to control the built-in equipment. The device may operate the linear actuator, the chuck, and the cutting/separating section.

FIG. 2 is a schematic diagram of a stick intermediate and a magazine used in the metering mixer of this embodiment.
Here, the stick intermediate is shaped like a bar having a circular cross section. Here, the cross-sectional diameters 2001a, 2001b, 2001c of the

stick intermediates

1002a, 1002b, 1002c are Ra, Rb, Rc, respectively. Depending on the amount of active ingredient required in the final mixture, intermediate sticks of varying diameters and cross-sectional areas are employed.
Here, a rod-shaped intermediate stick with a circular cross section was adopted, and a stick intermediate with a different cross-sectional area depending on the size of the active ingredient was adopted, but the valuation of the stick intermediate that can be used in the present invention is , but not limited to. Stick intermediates having different lengths, cross-sectional shapes, or cross-sectional areas may be employed depending on not only the size of the required active ingredient but also the type of active ingredient.

The trailing

end

2002a, 2002b, 2002c of each intermediate stick is modified in shape to identify the type of intermediate stick.
The rear end portion 2002a has a square cross section and is partially reduced in size to form a characteristic notch.
The rear end portion 2002b is modified to form two flange-like protruding portions larger than the diameter of the main body.
The rear end portion 2002c has a diameter smaller than that of the main body and is modified by forming a flange-like protrusion at one location.
In this way, depending on the type and size of the active ingredient, by changing the shape of the rear end of the stick intermediate that is not used for weighing and mixing, the identification of which type of stick intermediate is increased, and the weighing and mixing work can be improved. It is effective in preventing the person concerned from taking the wrong intermediate.

The surface of the stick intermediate is coated and protected. Further, each stick intermediate is stored in a

magazine

1001a, 1001b, 1001c for protection from damage during supply or distribution and for convenient handling during transportation.
When used in the metering mixer, it is taken out from magazine take-out

openings

2002a, 2002b, 2002c.
Here, a micro RFID may be attached or embedded in each magazine or individual intermediate sticks for management of transportation and storage of the magazines, and management of transportation and storage may be made efficient by reading the RFID.

FIG. 3 is a flow chart showing the stick intermediate production process of the present embodiment.
In the active ingredient charging step S3001, the active ingredient in the quantity necessary for the stick intermediate to be produced is introduced into the stick intermediate producing tank by the stick intermediate manufacturer.
Here, for intermediate sticks having the same active ingredient, intermediate sticks having different concentrations are added by changing the amount of each intermediate stick to be added.

In the additive mixing step S3002, additives necessary for the charged active ingredients are mixed by the intermediate stick manufacturer.
Here, base solvents, binders, lubricants, pH adjusters and the like are used as additives.

In the homogenization step S3003, the charged active ingredients and additives are stirred and homogenized by the stick intermediate manufacturer.

In the molding step S3004, the mixture is put into a mold whose main body is a stick with a predetermined cross-sectional shape and whose rear end has a deformed shape by a stick intermediate manufacturer, and the homogenized active ingredient and additive are added. A mixture of is injected and solidified into a bar shape with a deformed rear end.
Among the above additives, the binder may be mixed in this molding step.

In the coating step S3005, the stick intermediate body manufacturer coats the surface of the mixture solidified into a rod shape to complete the stick intermediate body.

In the magazine storage step S3006, a predetermined number of coated intermediate sticks are stored in the magazine by the stick intermediate manufacturer.

In the supply/distribution step S3007, the intermediate stick manufacturer, supplier, or distributor distributes the magazine containing the intermediate sticks and supplies them to the users of the intermediate sticks.

In this way, the active ingredient density is uniformly generated, and the stick intermediate molded into a rod shape with a predetermined diameter or cross-sectional area is easier to handle than the small-particle active ingredient, and the length does not require skill. There is an effect that the weighing accuracy can be obtained by the weighing operation.
In addition, by producing stick intermediates with the same type of active ingredient but different concentrations of the active ingredient, the desired dosage can be achieved by utilizing stick intermediates with different concentrations in the field of dispensing or self-regulation. has the effect of facilitating accurate weighing.
Furthermore, since the coating is applied to the surface and stored in the magazine, there is little risk of damage during transportation and storage, and handling is facilitated to maintain quality during supply and distribution. In addition, it becomes easier for consumers to whom the product is supplied to store and use it.

FIG. 4 is a schematic diagram showing the functional configuration of the weighing mixer of this embodiment.
Here, the parts described in FIG. 1 are indicated by the same figure numbers.
The weighing and mixing machine 1003 includes

insertion ports

4001a, 4001b, and 4001c for intermediate sticks,

linear actuators

4002a, 4002b, and 4002c, chucks 4003a, 4003b, and 4003c for fixing the intermediate sticks moved by the linear actuators at their positions, cutting and separating It is composed of

sections

4004a, 4004b, 4004c, a collection/mixing section 1007, and a homogenization section 1008. FIG.

　The weighing and mixing machine is used by first selecting the stick intermediates that you need and inserting them into any or all of the outlets.

The intermediate stick inserted until the tip is aligned with the cutting position is linearly moved by the

linear actuators

4002a, 4002b, 4002c interlocking with the rotation of the

dials

1004a, 1004b, 1004c shown in FIG.

The length of each stick intermediate to be cut and separated is measured from the initial position set by aligning the tip with the cutting position and the amount of linear movement, and is displayed on the

display portions

1005a, 1005b, and 1005c shown in FIG. be.

A plurality of intermediate sticks whose lengths corresponding to required capacities are measured are fixed by

chucks

4003a, 4003b, and 4003c in a state of protruding from the cutting/

separating portions

4004a, 4004b, and 4004c by that length, and cut. It is cut and separated by separating parts 4004a to 4004c.
The operation for weighing is to initially set the tip of the stick intermediate to a predetermined initial position, and measure the length, which is the linear movement amount, so that the length corresponding to the required capacity protrudes from the cut separation part. Therefore, no special operation or mastery of operation is required, and it is possible to achieve the accuracy of weighing a portion more easily than the measurement of weight or volume.

Although the number of inlets, linear actuators, cutting separators and chucks is three here, the number of inlets, linear actuators, cutting separators and chucks of the metering mixer of the present invention is limited to three. Instead, it is possible to employ a configuration that increases or decreases as necessary.

The intermediate sticks 4005 that are cut and separated from the original intermediate sticks are collected and mixed in the collecting/mixing section 1007 .
The collected and mixed intermediate sticks are chopped into fine pieces and homogenized by a homogenizer 4006 in a homogenizer 1008 to produce a final mixture 1009 .
The final mixture produced is discharged from the discharge port 4007 .

Stick intermediates having different cross-sectional areas are used by increasing or decreasing the cross-sectional diameters such as Ra, Rb, or Rc, as described above, depending on the required amount of the raw material to be the active ingredient.

FIG. 5 is a schematic plan view showing the main configuration of the tablet press 1010. As shown in FIG.
A tablet press feeder 5001 adapted to the shape of the discharge port 4007, a plurality of recesses 5002 for receiving the final mixture supplied from the tablet press feeder, and a pressure unit 5003 for compressing the final mixture stored in the recesses with a punch. , and a discharge section 5004 for discharging a compressed tablet.

FIG. 6 is a schematic side see-through view showing the main configuration of the liquid generator 1011. As shown in FIG.
It consists of a liquid generator inlet 6001 adapted to the shape of the outlet 4007, a solution inlet 6002, a stirrer 6003, and an outlet 6004 for taking out the liquid product.

FIG. 7 is a schematic side see-through view showing the main configuration of the packing machine 1012. As shown in FIG.
A storage section 7002 having a packaging machine input port 7001 adapted to the shape of the discharge port 4007, a distribution section 7003 distributing the final mixture that has been input, a packing section 7004 that packs the distributed final mixture, and the final mixture is It is composed of a discharge section 7005 for discharging the packed medicine pack and a medicine pack 7006 for which the packaging is completed and discharged.

A combination of the above configurations may be applied to a system including an automatic dispensing machine adapted to individual drug treatment. An automatic dispensing machine may incorporate a metering mixer as described herein. The active ingredients required for drug dispensing or self-regulation required for drug therapy of targeted individuals are provided as intermediate sticks contained in magazines.

(Dosing machine and weighing and mixing machine incorporated into the dosing machine)
FIG. 8 is a schematic side see-through view showing the main configuration of the dispensing machine of this embodiment.
A dosing machine 8001 incorporates a metering/mixing machine 8002 having the configuration shown in the first embodiment inside the housing of the dosing machine. A mixture produced by a metering mixer 8002 is discharged to a cylinder 8004 from a discharge port 8003 having a valve mechanism. A plunger rod 8005 is operated to administer medication from an administration port 8006 .
Here, by setting the size of the dosing machine housing to at least 8 cm or less in the horizontal direction and 15 cm or less in the vertical direction of this schematic side perspective view, which is the so-called smartphone size or less, so that an individual can easily carry it in a pocket or the like. and

FIG. 9 is an image diagram showing a state in which the final mixture 9001 produced by the weighing mixer 8002 of this embodiment is discharged into the cylinder 8004. As shown in FIG.

FIG. 10 is an image diagram showing how the final mixture 10001 in the cylinder is dispensed by pushing out the plunger rod 8005 by the user.

Here, the final mixture is administered as it is, but a method of injecting a solvent such as water into the cylinder while the final mixture is contained in the cylinder to form a solution and then administering may be used.

By providing a dosing machine incorporating the weighing and mixing machine as described above, an individual can easily self-adjust and administer drugs necessary for their own drug treatment using intermediate sticks that are easy to handle. becomes possible.

INDUSTRIAL APPLICABILITY The present invention is applicable in the pharmaceutical industry, the pharmaceutical industry, the cosmetic industry, the cooking industry, or the coating industry. Moreover, it is applicable in the production process of various factories.

1001a magazine 1002a intermediate stick 1003 weigh mixer 1010 tablet press
1011 Liquid generator 1012 Packaging machine

Claims

Using multiple types of stick intermediates with uniform active ingredients per length, which are produced in rods of a predetermined diameter or cross-sectional area by mixing additives necessary for active ingredients at a stick intermediate manufacturer in advance. A system for dispensing or self-regulating drugs required for drug therapy,
A system comprising a weigh mixer that weighs and cuts apart individual said stick intermediates by measuring their length to produce a final blend of intended formulation.
2. The intermediate stick according to claim 1, wherein the plurality of types of intermediate sticks include intermediate sticks having the same type of active ingredient but different cross-sectional areas of cross sections or different concentrations to be uniform. system.
2. The system according to claim 1, wherein the shape of the non-use end of the intermediate stick is changed according to the type or size of the active ingredient.
2. The system according to claim 1, wherein said additive is at least one selected from base solvents, binders, lubricants and pH adjusters.
3. The system of claim 1, wherein said intermediate stick is coated.
2. The system according to claim 1, further comprising a magazine capable of accommodating a plurality of said intermediate sticks used for supplying and distributing said intermediate sticks.
In the system of claim 1, a) tableting means for mixing necessary additives after producing the final mixture and tableting, b) mixing necessary additives after producing the final mixture 2. The system according to claim 1, further comprising at least one selected from: a liquid generating means for generating a liquid by mixing and c) a packaging means for packaging the final mixture after generating the final mixture.
2. The system according to claim 1, wherein said metering and mixing machine is capable of using a stick intermediate having a cross-sectional area of said cross-section that is increased or decreased according to the required amount of the raw material that will be the active ingredient.
2. The system of claim 1, wherein said system includes an automated dispensing machine adapted to individual medication, wherein said metering and mixing machine is incorporated into said automated dispensing machine.