WO2022164300A1 - Appareil d'irradiation par ultrasons focalisés pour animal de laboratoire utilisant des données d'image tridimensionnelle - Google Patents

Appareil d'irradiation par ultrasons focalisés pour animal de laboratoire utilisant des données d'image tridimensionnelle Download PDF

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WO2022164300A1
WO2022164300A1 PCT/KR2022/095012 KR2022095012W WO2022164300A1 WO 2022164300 A1 WO2022164300 A1 WO 2022164300A1 KR 2022095012 W KR2022095012 W KR 2022095012W WO 2022164300 A1 WO2022164300 A1 WO 2022164300A1
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focused ultrasound
experimental animal
head
transducer
base frame
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PCT/KR2022/095012
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English (en)
Korean (ko)
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이지현
김봉수
나영철
장원석
Original Assignee
가톨릭관동대학교산학협력단
연세대학교 산학협력단
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Publication of WO2022164300A1 publication Critical patent/WO2022164300A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
    • A61B5/004—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0042—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
    • A61B5/4064—Evaluating the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • A61B6/032—Transmission computed tomography [CT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/501—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of the head, e.g. neuroimaging or craniography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D3/00—Appliances for supporting or fettering animals for operative purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D3/00—Appliances for supporting or fettering animals for operative purposes
    • A61D2003/003—Appliances for supporting or fettering animals for operative purposes with head or neck restraining means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0021—Neural system treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0082—Scanning transducers

Definitions

  • the present invention relates to a focused ultrasound irradiation apparatus for laboratory animals, and more particularly, when irradiating focused ultrasound waves to a specific region in the brain of an experimental animal, a specific location through information obtained through a three-dimensional anatomical image without cutting the scalp It relates to a focused ultrasound irradiation device for laboratory animals using three-dimensional image data that can automatically position a transducer on a pole and irradiate focused ultrasound waves.
  • blood vessels in the brain have a structure called the blood-brain barrier.
  • the cells of the blood-brain barrier function as an important barrier to maintain brain homeostasis by preventing toxic substances in the blood from penetrating into the cerebral parenchyma and maintaining physiological functions such as metabolism.
  • a brain disease state it acts as an obstacle to administering various therapeutic substances such as drugs or genes in the blood into the brain parenchyma, making treatment difficult.
  • the present invention sets up a focused ultrasound irradiation area through preprocessing of anatomical image data obtained in advance prior to focused ultrasound irradiation
  • An object of the present invention is to provide a focused ultrasound irradiation device for laboratory animals using 3D image data that can automatically fix the position of the deucator and has non-invasiveness that does not require scalp incision.
  • the present invention relates to a focused ultrasound irradiation apparatus for laboratory animals used in preclinical studies using laboratory animals, comprising: a base frame in which the laboratory animal is located on the upper side; at least one first fixing part installed on the upper side of the base frame and fixing the experimental animal; at least one second fixing part installed on the upper side of the base frame and fixing the head of the experimental animal; a plurality of first markers attached to the head of the experimental animal and detectable by an external imaging device that performs any one imaging method selected from CT, MRI, fMRI, and ultrasound; a plurality of optical cameras for photographing a plurality of the first markers; A transducer for generating a focused ultrasound is installed, and is installed so as to be movable on the upper side of the base frame, and a moving unit for attaching the transducer to a specific part of the head of the experimental animal; at least one or more second markers attached to the side of the transducer and photographed by the optical camera; and a control device including a matching unit and a control unit.
  • the matching unit receives the 3D image data of the head of the experimental animal to which the first marker is attached from the photographing device, and based on the positions of the plurality of first markers photographed by the optical camera, the first marker and the position of the second marker may be matched with the coordinate system of the image data.
  • control unit may control the moving unit so that the specific portion and the transducer are in close contact with the specific portion of the input device.
  • the transducer may generate a focused ultrasound wave having a depth and focus received by the input device.
  • the moving unit a first moving frame located above the base frame; a second moving frame installed to be slidably movable in both directions along the longitudinal direction of the first moving frame from an upper side of the first moving frame; a third moving frame installed to be slidably movable in both directions along the longitudinal direction of the second moving frame from one side of the second moving frame; and a rotating part fixed to one side of the lower portion of the third moving frame and installed, and moving upward or downward as the third moving frame moves.
  • the transducer may be rotatably installed at a lower portion of the rotating part so that the focused ultrasound is irradiated while forming a predetermined angle with a specific part of the head of the experimental animal.
  • first joint is a rotation axis horizontal to the base frame, the rotation unit; and a second joint that is a rotational axis perpendicular to the base frame, wherein each of the first joint and the second joint is controlled by the controller and can be rotated so that the transducer forms a specific angle with the head of the experimental animal. can be adhered to.
  • the base frame is formed with a plurality of through holes
  • the second fixing portion is a flat body to be installed on the upper side of the base frame; a pair of fitting posts formed by bending one end and the other end of the body downward; a protruding pillar formed to protrude upward from the body; One end of the spring of an elastic material is fixed to one side of the inside of the protruding pillar; and a control bar having one end coupled to the other end of the spring and the other end fixing the head of the experimental animal.
  • the second fixing part may further include a contact bar attached to the other end of the control bar to be in close contact with the head of the experimental animal.
  • the contact band may be made of a sponge or leather having elasticity.
  • the apparatus for irradiating focused ultrasound for laboratory animals using 3D image data of the present invention uses 3D anatomical images such as MRI, CT or fMRI and ultrasound to irradiate focused ultrasound despite differences in the shape of laboratory animals. Focused ultrasound can be accurately irradiated to the location.
  • the process for the focused ultrasound irradiation can be simplified.
  • FIG. 1 is a perspective view of a focused ultrasound irradiation apparatus for laboratory animals using three-dimensional image data according to an embodiment of the present invention.
  • FIG. 2 is a perspective view illustrating a base frame according to an embodiment of the present invention.
  • FIG. 3 is a perspective view illustrating a second fixing part according to an embodiment of the present invention.
  • FIG. 4 is a perspective view of a rotating part according to an embodiment of the present invention.
  • FIG. 5 is a conceptual diagram schematically illustrating the main configuration of a focused ultrasound irradiation apparatus for laboratory animals using three-dimensional image data according to an embodiment of the present invention.
  • FIG. 6 is a perspective view illustrating a state in which the transducer according to an embodiment of the present invention is in close contact with a specific part of the head of an experimental animal.
  • FIG. 7 shows a method of irradiating focused ultrasound to the head of an experimental animal according to an embodiment of the present invention.
  • FIG. 1 is a perspective view of a focused ultrasound irradiation apparatus 100 for laboratory animals using three-dimensional image data according to an embodiment of the present invention
  • FIG. 2 is a base frame 110 according to an embodiment of the present invention
  • 3 is a perspective view showing the second fixing part 130 according to an embodiment of the present invention
  • FIG. 4 is a perspective view of the rotating part 164 according to an embodiment of the present invention
  • FIG. 5 is It is a conceptual diagram briefly illustrating the main configuration of the focused ultrasound irradiation apparatus 100 for laboratory animals using three-dimensional image data according to an embodiment of the present invention.
  • the base frame 110 in the focused ultrasound irradiation apparatus 100 for laboratory animals used in preclinical studies using laboratory animals according to an embodiment of the present invention, the base frame 110, the first high Government 120 , second fixing unit 130 , a plurality of first markers 140 , a plurality of optical cameras 150 , a moving unit 160 , at least one or more second markers 170 , and a control device 180 . ) is included.
  • the base frame 110 may be fixed to the upper side in a flat rectangular shape using one or more of the first fixing part 120 and the second fixing part 130 so that the anesthetized experimental animal 60 does not move.
  • a plurality of through-holes 111 through which the first fixing part 120 penetrates and is bound or the second fixing part 130 can be fitted may be formed in the base frame 110 .
  • At least one or more of the first fixing part 120 is installed on the upper side of the base frame 110 to fix the body of the experimental animal 60, when the experimental animal 60 is a mouse as in an embodiment of the present invention.
  • the front legs and the hind legs are bound and fixed by the first fixing part (120).
  • the first fixing part 120 may be a string made of leather or textile material that can tighten the arms and legs of the experimental animal 60 , and in this case, the first fixing part 120 has one end of the base frame 110 .
  • the arm of the experimental animal 60 or A fixed space 121 into which the legs can enter may be formed.
  • At least one second fixing part 130 is installed on the upper side of the base frame 110 to fix the head of the experimental animal 60 so that the irradiation part of the focused ultrasound does not move.
  • the second fixing part 130 includes a flat body 131 to be installed on the upper side of the base frame 110 , and a pair formed by bending one end and the other end of the body 131 downward.
  • a spring 134 of an elastic material having one end fixed to one side of the fitting post 132 of the body 131 and a protruding post 133 protruding upward of the body 131 and one end of the protruding post 133, and one end is the It is coupled to the other end of the spring 134 and the other end is attached to the control rod 135 for fixing the head of the experimental animal 60 and the other end of the control rod 135 to be in close contact with the head of the experimental animal 60 .
  • It may include a contact stand 136 .
  • the contact table 136 is made of a sponge or leather having elasticity to prevent the head of the experimental animal 60 from sliding.
  • the fitting post 132 is fitted while being inserted into any one of the plurality of through-holes 111 formed in the base frame 110 and the other one, the second fixing part 130 is formed in the base frame 110 . ) can be fixed on the upper side.
  • the first fixing part 120 is bound to the base frame 110 in response to the position of the limbs of the experimental animal 60 having different sizes, and the experimental animal 60 by the first fixing part 120 of the limbs are fixed on the base frame 110 , and the fitting post 132 of the second fixing part 130 corresponds to the size of the head of the experimental animal 60 , and the through hole 111 of the base frame 110 and After fitting, the head of the experimental animal 60 and the contact rod 136 are brought into close contact with each other by the spring 134 and the control rod 135 , and the head of the experimental animal 60 may be fixed so as not to move.
  • the head of the experimental animal 60 is fixed by using two of the second fixing units 130 , and any one of the two second fixing units 130 is the experimental animal 60 . ) in close contact with one side of the head, and the other of the two second fixing parts 130 is in close contact with the other side of the head of the experimental animal 60, so that the head of the experimental animal 60 is in close contact with the second fixing part 130 is fixed by
  • the experimental animals 60 having different sizes can be effectively and easily fixed on the base frame 110, so that the movement of the experimental animal 60 in irradiating the focused ultrasound to a specific region 40 in the brain can be minimized.
  • the plurality of first markers 140 may be attached to the head of the experimental animal 60 and detectable by any one imaging device 20 selected from CT, MRI, fMRI, and ultrasound.
  • each of the first markers 140 may be formed of a light reflective material that reflects the light used by the optical camera 150 .
  • the first marker 140 may be formed of a material that reflects infrared rays so that the infrared camera can detect the infrared rays by reflecting the infrared rays irradiated from the infrared camera.
  • a marker used for motion capture, etc. uses a spherical marker to enable uniform reflection in any direction, but in the present embodiment, a hemispherical, semi-cylindrical, etc.
  • each of the first markers 140 may be attached to the front of the head of the experimental animal 60 at a predetermined distance from each other, and in order to measure the precise position of the head of the experimental animal 60, the experimental animal ( 60) can be further attached to both sides and rear of the head.
  • Each of the plurality of optical cameras 150 photographed the first marker 140 attached to the head of the experimental animal 60 in a state of being fixed to the focused ultrasound irradiation apparatus 100 for an experimental animal using three-dimensional image data. do.
  • the plurality of optical cameras 150 are photographing the first marker 140 and the second marker 170 using the five optical cameras 150 , and the plurality of optical cameras 150 .
  • ) is installed to be spaced apart from the front of the head of the experimental animal 60 by a predetermined distance, and the first marker 140 attached to the front of the head of the experimental animal 60 among the first markers 140 can be photographed. It was installed to be fixed to the focused ultrasound irradiation apparatus 100 for laboratory animals using three-dimensional image data so that the remaining optical cameras 150 are respectively installed in a diagonal direction on the base frame 110 to the first marker 140. and the second marker 170 is being photographed.
  • the positions of the first marker 140 and the second marker 170 can be accurately tracked, but at least one of the plurality of optical cameras 150 is 60) is preferably installed to be fixed to the focused ultrasound irradiation apparatus 100 for laboratory animals using three-dimensional image data so that the first marker 140 attached to the front of the head can be photographed.
  • the moving unit 160 is provided with a transducer 190 that generates a focused ultrasound, is installed to be movable on the upper side of the base frame 110, and is controlled by the control device 180 to control the transducer. (190) can be in close contact with a specific part (40) of the head of the experimental animal (60).
  • the moving unit 160 is a first moving frame 161, a second controlled using three motors.
  • the moving frame 162, the third moving frame 163 and the transducer 190 are in close contact with the specific part 40 of the experimental animal a specific angle ( ⁇ ) and a rotating part 164 that can precisely control the position ) may be included.
  • the first moving frame 161 may be installed above the base frame 110 .
  • a first moving guide 1611 for guiding the movement of the second moving frame 162 is formed on the first moving frame 161, and the first moving frame along the first moving guide 1611.
  • a first movable assembly 1612 slidable in both directions D1 along the longitudinal direction of the first moving frame 161 from the upper side of the 161 is installed, and is installed at one end of the first moving frame 161,
  • a first rail (not shown, 1614 ) may be installed inside the first moving frame 161 .
  • the second moving frame 162 may be installed above the first moving frame 161 to be slidably movable in both directions D1 along the longitudinal direction of the first moving frame 161 .
  • the second moving frame 162 is installed on one side of the first moving assembly 1612, and the first moving assembly 1612 is a first moving frame along the first moving guide 1611 ( As it moves in the longitudinal direction of 161 , the second moving frame 162 is slidably movable on the upper side of the first moving frame 161 .
  • a second moving guide 1621 for guiding the movement of the third moving frame 163 is formed on one side of the second moving frame 162 , and a second moving frame 162 is formed along the second moving guide 1621 .
  • a second moving assembly 1622 that is slidable in both directions (D2) is installed, and is installed at one end of the second moving frame 162,
  • a second rail (not shown, 1626) that is movable in both directions (D2) along the second movement guide 1621 according to the driving of the second motor 1625 that is controlled by the control device 180 to generate a driving force. It may be installed inside the second moving frame 162 .
  • the third moving frame 163 is installed to be movable from one side of the second moving frame 162 to the upper side (D3) or the lower side (D4) in the longitudinal direction of the second moving frame 162 to be movable.
  • the third moving frame 163 is installed on one side of the second moving assembly 1622, and the second moving assembly 1622 is controlled by the control device 180 to generate a driving force.
  • a motor 1623 is installed, and on one side of the second moving assembly 1622, a guide assembly 1624 for guiding the movement to the upper side (D3) or the lower side (D4) of the third moving frame 163 is provided.
  • the third motor 1623 may move the third rail (not shown, 1632 ) installed inside or outside the third moving frame 163 to the upper side D3 or the lower side D4 .
  • a third moving guide 1631 into which the guide assembly 1624 is inserted may be formed along the longitudinal direction of the third moving frame 163 .
  • the rotating part 164 according to an embodiment of the present invention is fixed to one side of the lower portion of the third moving frame 163 and installed, and as the third moving frame 163 moves, It can move upward (D3) or downward (D4).
  • the transducer 190 may be installed rotatably so that the focused ultrasound is irradiated while forming a specific angle ⁇ with a specific part 40 of the head of the experimental animal 60 at the lower part of the rotating part 164.
  • the rotating part 164 is a first joint 1641 which is a rotation axis horizontal to the base frame 110 controlled by the control device 180 and a first joint 1641 which is a rotation axis perpendicular to the base frame 110 . It may include two joints 1642 . As each of the first joint 1641 and the second joint 1642 is rotatable, the transducer 190 may be in close contact with the head of the experimental animal 60 while forming a specific angle ⁇ .
  • At least one or more of the second markers 170 may be attached to the outer surface of the transducer 190 installed in the rotating part 164 and may be detectable by the optical camera 150 .
  • Each of the second markers 170 may be formed of a light reflective material that reflects the light used by the optical camera 150 , like the first marker 140 .
  • the second marker 170 may be formed of a material that reflects infrared rays so that the infrared camera can detect the infrared rays by reflecting the infrared rays irradiated from the infrared camera.
  • the second marker 170 may be attached to the outer surface of the transducer 190 installed on the rotating part 164 , and for precise position measurement of the head of the experimental animal 60 . At least one or more second markers 170 may be attached to the outer surface of the transducer 190 and installed by the optical camera 150 .
  • the control device 180 may include a matching unit 181 and a control unit 182 .
  • the control device 180 may be provided on one side of the base frame, or connected to the optical camera, the moving unit, and the transducer by wire, and may be provided outside.
  • the matching unit 181 is the head of the experimental animal 60 to which the first marker 140 is attached from an external imaging device 20 that performs any one imaging method selected from CT, MRI, fMRI, and ultrasound.
  • the position of the first marker 140 and the second marker 170 based on the positions of the plurality of first markers 140 photographed by the optical camera 150 by receiving the 3D image data of the image Match the coordinate system of the data.
  • the focused ultrasound irradiation apparatus 100 for laboratory animals using three-dimensional image data uses the first marker 140 photographed through the optical camera 150 through the experimental animal 60.
  • the position of the first marker 140 photographed by the optical camera 150 is detected by the position of the head of A specific region 40 in the brain of the experimental animal 60 to which the focused ultrasound is irradiated through an external image display device 70 (not shown) and an input device 50 in which the image data is displayed in three dimensions by matching with It can be selected, and it is possible to recognize the location of a specific region 40 in the brain of the actual experimental animal 60 to which the focused ultrasound is irradiated.
  • the focused ultrasound irradiation apparatus 100 for laboratory animals using three-dimensional image data is the first marker 140 and the second marker 170 photographed through the optical camera 150.
  • the relative coordinates of the second marker 170 are calculated based on the position of the first marker 140 through It can be calculated and tracked.
  • the image data captured by the selected photographing device 20 through the matching unit 181 matches the actual position of the head of the experimental animal 60 and the position of the transducer 190, and the actual experimental animal ( The position of the head of 60 and the position of the transducer 190 can be tracked.
  • the controller 182 may control the moving unit 160 so that the specific part 40 and the transducer 190 are in close contact with the specific part 40 in the input device 50 .
  • the image data captured by the selected photographing device 20 is displayed on the image display device 70 (not shown) in three dimensions, and the experimenter of the pre-clinical test stage is the three-dimensional image display device 70 , not shown), while viewing the three-dimensional image data taken by the selected imaging device 20 displayed on the input device 50, a specific part 40 in the brain of the experimental animal 60 to which the focused ultrasound is irradiated can be selected through
  • the focused ultrasound irradiation apparatus for laboratory animals using three-dimensional image data is a laboratory animal 60 to which the focused ultrasound is irradiated by the input device 50.
  • the controller 182 controls the position of the head of the experimental animal 60 calculated through the first marker 140 and the position of the head of the experimental animal 60 calculated through the second marker 170 .
  • the first motor 1613 and the second By controlling the motor 1625 and the third motor 1623, the transducer 190 is moved above the specific part 40 of the experimental animal.
  • the control unit 182 calculates a specific angle ⁇ at which the transducer 190 is in close contact with the specific part 40 in order to make the transducer 190 in close contact with the specific part 40, By controlling the rotation unit 164 at the angle ⁇ and controlling the third motor 1623, the transducer 190 may be in close contact with the specific portion 40 while forming the specific angle ⁇ .
  • the focus and depth of the focused ultrasound irradiated through the transducer 190 may be input through the input device 50, the transducer 190 is the specific portion 40 ), the focused ultrasound waves having a focus and a depth input through the input device 50 can be irradiated to a specific region 40 in the brain of the experimental animal 60 .
  • the method of irradiating the focused ultrasound to the head of the experimental animal (60) by the focused ultrasound irradiation apparatus for laboratory animals using the three-dimensional image data of the present invention is a first marker on the head of the experimental animal (60) Attaching 140, imaging the head of the experimental animal 60 by any one imaging device 20 selected from CT, MRI, fMRI and ultrasound, removing the anesthetized experimental animal 60
  • a step of fixing on the base frame 110 using the first fixing part 120 and the second fixing part 130 , the first marker 140 and the second marker 170 are photographed by the optical camera 150 .
  • the control unit 182 matching the first marker 140 photographed by the optical camera 150 to the position where the first marker 140 appearing on the image data is displayed, the control unit 182 is the image Step of matching the second marker 170 to the image data based on the position of the first marker 140 matched to the data, the specific intracerebral of the experimental animal 60 to be irradiated with the focused ultrasound by the input device 50
  • the step of selecting the part 40, the step of setting the focus and distance of the focused ultrasound irradiated from the transducer 190 by the input device 50, is controlled by the control unit 182 and installed in the moving unit 160
  • the rotating unit 164 is controlled by the control unit 182 so that the transducer 190 moves with the head of the experimental animal 60
  • a step of close contact while forming a specific angle ( ⁇ ) is made, including the step of irradiating the focused ultrasound from the transducer (190).
  • the focused ultrasound irradiation apparatus for laboratory animals using three-dimensional image data in the preclinical stage, in order to accurately and non-invasively irradiate the focused ultrasound energy to a desired area, prior to the focused ultrasound irradiation
  • pre-processing of the acquired anatomical image data it is possible to set the focused ultrasound irradiation area and to automatically fix the position of the transducer, and there is no need to cut the scalp.

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  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

La présente invention concerne un appareil d'irradiation par ultrasons focalisés, pour un animal de laboratoire, utilisé dans une étude préclinique utilisant un animal de laboratoire, l'appareil d'irradiation par ultrasons focalisés comprenant : un cadre de base ayant un animal de laboratoire positionné sur le côté supérieur de celui-ci; au moins une première partie de fixation disposée sur le côté supérieur du cadre de base et destinée à fixer l'animal de laboratoire; au moins une seconde partie de fixation disposée sur le côté supérieur du cadre de base et destinée à fixer la tête de l'animal de laboratoire; une pluralité de premiers marqueurs qui sont fixés à la tête de l'animal de laboratoire et qui peuvent être détectés par un dispositif d'imagerie externe effectuant n'importe quel procédé d'imagerie sélectionné parmi TDM, IRM, IRMf et par ultrasons; une pluralité de caméras optiques pour capturer des images de la pluralité de premiers marqueurs; une unité de déplacement sur laquelle est disposé un transducteur pour générer des ultrasons focalisés, disposée de façon mobile sur le côté supérieur du cadre de base, et amener le transducteur en contact avec une partie spécifique de la tête de l'animal de laboratoire; au moins un second marqueur fixé à la surface latérale du transducteur pour être capturé en image par les caméras optiques ; et un appareil de commande comprenant une unité d'adaptation et une unité de commande.
PCT/KR2022/095012 2021-01-27 2022-01-14 Appareil d'irradiation par ultrasons focalisés pour animal de laboratoire utilisant des données d'image tridimensionnelle WO2022164300A1 (fr)

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