WO2022162620A2 - Cleansing composition providing enhanced deposition of salicylic acid for acne treatment - Google Patents
Cleansing composition providing enhanced deposition of salicylic acid for acne treatment Download PDFInfo
- Publication number
- WO2022162620A2 WO2022162620A2 PCT/IB2022/050780 IB2022050780W WO2022162620A2 WO 2022162620 A2 WO2022162620 A2 WO 2022162620A2 IB 2022050780 W IB2022050780 W IB 2022050780W WO 2022162620 A2 WO2022162620 A2 WO 2022162620A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- cationic
- acid
- cosmetic composition
- gum
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 238
- 230000008021 deposition Effects 0.000 title claims abstract description 37
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 32
- 206010000496 acne Diseases 0.000 title claims abstract description 32
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical group OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 title claims description 98
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 title claims description 54
- 229960004889 salicylic acid Drugs 0.000 title claims description 49
- 239000002537 cosmetic Substances 0.000 claims abstract description 65
- 229920006317 cationic polymer Polymers 0.000 claims abstract description 59
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 52
- 150000001277 beta hydroxy acids Chemical class 0.000 claims abstract description 46
- 239000004094 surface-active agent Substances 0.000 claims abstract description 34
- 230000014759 maintenance of location Effects 0.000 claims abstract description 20
- 239000008365 aqueous carrier Substances 0.000 claims abstract description 6
- 125000002091 cationic group Chemical group 0.000 claims description 34
- 229920000642 polymer Polymers 0.000 claims description 34
- 150000003839 salts Chemical class 0.000 claims description 29
- -1 hydroxypropyl Chemical group 0.000 claims description 28
- 239000003755 preservative agent Substances 0.000 claims description 26
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 18
- 229920001661 Chitosan Polymers 0.000 claims description 17
- 239000003945 anionic surfactant Substances 0.000 claims description 12
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 11
- 239000003906 humectant Substances 0.000 claims description 11
- 244000303965 Cyamopsis psoralioides Species 0.000 claims description 10
- 239000002280 amphoteric surfactant Substances 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 239000002736 nonionic surfactant Substances 0.000 claims description 9
- 239000011780 sodium chloride Substances 0.000 claims description 9
- 229940048109 sodium methyl cocoyl taurate Drugs 0.000 claims description 9
- WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical compound CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 claims description 8
- 229920000591 gum Polymers 0.000 claims description 8
- 238000005259 measurement Methods 0.000 claims description 8
- 229920000058 polyacrylate Polymers 0.000 claims description 8
- 244000215068 Acacia senegal Species 0.000 claims description 7
- 239000004599 antimicrobial Substances 0.000 claims description 7
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims description 7
- MQFYRUGXOJAUQK-UHFFFAOYSA-N 2-[2-[2-(2-octadecanoyloxyethoxy)ethoxy]ethoxy]ethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOCCOCCOCCOC(=O)CCCCCCCCCCCCCCCCC MQFYRUGXOJAUQK-UHFFFAOYSA-N 0.000 claims description 6
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 6
- 230000009918 complex formation Effects 0.000 claims description 6
- 229920001577 copolymer Polymers 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 6
- 229910052751 metal Inorganic materials 0.000 claims description 6
- 239000002184 metal Substances 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 5
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 5
- 229920000084 Gum arabic Polymers 0.000 claims description 5
- 235000010489 acacia gum Nutrition 0.000 claims description 5
- 239000001110 calcium chloride Substances 0.000 claims description 5
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 5
- 239000002738 chelating agent Substances 0.000 claims description 5
- 230000003750 conditioning effect Effects 0.000 claims description 5
- 229940075529 glyceryl stearate Drugs 0.000 claims description 5
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 5
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 5
- VBSTXRUAXCTZBQ-UHFFFAOYSA-N 1-hexyl-4-phenylpiperazine Chemical compound C1CN(CCCCCC)CCN1C1=CC=CC=C1 VBSTXRUAXCTZBQ-UHFFFAOYSA-N 0.000 claims description 4
- GLJADRYELJNXDG-UHFFFAOYSA-N 2-oxopyrrolidine-1-carboxylic acid;zinc Chemical compound [Zn].OC(=O)N1CCCC1=O GLJADRYELJNXDG-UHFFFAOYSA-N 0.000 claims description 4
- WUYGEUSUCRMJJG-UHFFFAOYSA-N 3-hydroxy-3,7,11-trimethyldodecanoic acid Chemical compound CC(C)CCCC(C)CCCC(C)(O)CC(O)=O WUYGEUSUCRMJJG-UHFFFAOYSA-N 0.000 claims description 4
- 235000006491 Acacia senegal Nutrition 0.000 claims description 4
- 229920000289 Polyquaternium Polymers 0.000 claims description 4
- 241000124033 Salix Species 0.000 claims description 4
- 229920002472 Starch Polymers 0.000 claims description 4
- JACRWUWPXAESPB-QMMMGPOBSA-N Tropic acid Natural products OC[C@H](C(O)=O)C1=CC=CC=C1 JACRWUWPXAESPB-QMMMGPOBSA-N 0.000 claims description 4
- 235000010418 carrageenan Nutrition 0.000 claims description 4
- 229920001525 carrageenan Polymers 0.000 claims description 4
- 239000000679 carrageenan Substances 0.000 claims description 4
- 229940113118 carrageenan Drugs 0.000 claims description 4
- 239000002826 coolant Substances 0.000 claims description 4
- 239000000945 filler Substances 0.000 claims description 4
- 229960004025 sodium salicylate Drugs 0.000 claims description 4
- ABBQHOQBGMUPJH-UHFFFAOYSA-N sodium;2-hydroxybenzoic acid Chemical compound [Na+].OC(=O)C1=CC=CC=C1O ABBQHOQBGMUPJH-UHFFFAOYSA-N 0.000 claims description 4
- 235000019698 starch Nutrition 0.000 claims description 4
- 239000002562 thickening agent Substances 0.000 claims description 4
- 229950003914 trethocanic acid Drugs 0.000 claims description 4
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 4
- IXIGWKNBFPKCCD-UHFFFAOYSA-N 2-hydroxy-5-octanoylbenzoic acid Chemical compound CCCCCCCC(=O)C1=CC=C(O)C(C(O)=O)=C1 IXIGWKNBFPKCCD-UHFFFAOYSA-N 0.000 claims description 3
- OYINQIKIQCNQOX-UHFFFAOYSA-M 2-hydroxybutyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCC(O)C[N+](C)(C)C OYINQIKIQCNQOX-UHFFFAOYSA-M 0.000 claims description 3
- 229920001817 Agar Polymers 0.000 claims description 3
- 241000416162 Astragalus gummifer Species 0.000 claims description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- 229920001615 Tragacanth Polymers 0.000 claims description 3
- 235000010419 agar Nutrition 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
- 239000003093 cationic surfactant Substances 0.000 claims description 3
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 3
- 239000001095 magnesium carbonate Substances 0.000 claims description 3
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 3
- 229920001277 pectin Polymers 0.000 claims description 3
- 239000001814 pectin Substances 0.000 claims description 3
- 235000010987 pectin Nutrition 0.000 claims description 3
- 239000001103 potassium chloride Substances 0.000 claims description 3
- 235000011164 potassium chloride Nutrition 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- 235000010356 sorbitol Nutrition 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 229920001285 xanthan gum Polymers 0.000 claims description 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 2
- 244000106483 Anogeissus latifolia Species 0.000 claims description 2
- 235000011514 Anogeissus latifolia Nutrition 0.000 claims description 2
- 229920002261 Corn starch Polymers 0.000 claims description 2
- 229920002148 Gellan gum Polymers 0.000 claims description 2
- 229920002907 Guar gum Polymers 0.000 claims description 2
- 239000001922 Gum ghatti Substances 0.000 claims description 2
- 229920000569 Gum karaya Polymers 0.000 claims description 2
- 229920000161 Locust bean gum Polymers 0.000 claims description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 2
- 229920001218 Pullulan Polymers 0.000 claims description 2
- 239000004373 Pullulan Substances 0.000 claims description 2
- 241001558929 Sclerotium <basidiomycota> Species 0.000 claims description 2
- 241001424341 Tara spinosa Species 0.000 claims description 2
- 239000000205 acacia gum Substances 0.000 claims description 2
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- 235000019314 gum ghatti Nutrition 0.000 claims description 2
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- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 2
- 235000010494 karaya gum Nutrition 0.000 claims description 2
- 235000010445 lecithin Nutrition 0.000 claims description 2
- 239000000787 lecithin Substances 0.000 claims description 2
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- CXMXRPHRNRROMY-UHFFFAOYSA-N n-Decanedioic acid Natural products OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 claims description 2
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- 229920002635 polyurethane Polymers 0.000 claims 2
- 239000004814 polyurethane Substances 0.000 claims 2
- AAIXGPLMFDSDPW-UHFFFAOYSA-K magnesium;potassium;chloride;sulfate Chemical compound [Mg+2].[K]Cl.[O-]S([O-])(=O)=O AAIXGPLMFDSDPW-UHFFFAOYSA-K 0.000 claims 1
- 210000003491 skin Anatomy 0.000 description 33
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
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- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229920001221 xylan Polymers 0.000 description 1
- 150000004823 xylans Chemical class 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- 239000002888 zwitterionic surfactant Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/737—Galactomannans, e.g. guar; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Definitions
- the present disclosure is directed to a skin care composition, in particular, cosmetic cleansing composition with high efficacy to deliver actives for addressing acne.
- Acne is a common skin disorder and is treated using a variety of different agents.
- Salicylic acid a mild beta-hydroxy acid, known for facilitating sloughing of dead skin cells and other cellular debris, is often used in treating acne, as well as other skin conditions that include psoriasis, keratoses, and ichthyoses.
- Commercial forms of cosmetic products that include salicylic acid include peels, cleansers, and leave on treatment in the forms of lotions, creams, and make ups.
- a challenge with many of these product forms is that they delivery salicylic acid that is only transiently available on the skin, such as in cleansers and peels, or that is in relatively low amounts, thus precluding sustained effectiveness on the skin for addressing acne and other skin conditions that benefit from the agent.
- composition that overcomes the shortcomings of the prior art and provides benefits that include the ability to cleanse skin and provide persistent delivery of a skin active, for example salicylic acid, after cleansing to enhance the treatment of skin with acne or that is prone to acne.
- a skin active for example salicylic acid
- a cosmetic composition for cleansing the skin in a rinse-off formulation that provides a stable disposition of an acne treatment active, for example, beta hydroxy acid, on the skin that is resistant to removal by rinsing and/or use of a cleansing apparatus, such as a cleansing brush.
- the inventive composition includes at least one or a combination of cationic polymers. The retention of acne treatment active on the skin even beyond cleansing, in some embodiments with a cleansing brush, effectively extends the duration of the acne treatment active availability on the skin for addressing acne and other skin conditions that are responsive to acne treatment actives, in particular, salicylic acid and other beta hydroxy acids, thereby providing sustained treatment in an otherwise rinsible formulation.
- the composition is formulated as a cleanser.
- the disclosure provides a cosmetic composition that includes at least acne treatment active comprising at least one beta hydroxy acid selected from -n- octanoylsalicylic acid, salicylate, sodium salicylate, willow extract, beta hydroxybutanoic acid, tropic acid, and trethocanic acid.
- the acne treatment active comprising at least one beta hydroxy acid is present in an aqueous carrier that includes one or more cationic polymers.
- the composition comprises at least one surfactant, or a combination of surfactants.
- composition when applied to a keratinous tissue demonstrates deposition and retention of the beta hydroxy acid on the keratinous tissue after rinsing with water in an amount representing about 60% to about 250% as compared with an amount deposited with a composition that lacks the one or more cationic polymers, wherein the deposition and enhanced salicylic acid retention may be demonstrated by measurement of color change resulting from complex formation between the acid and a metal salt, such as FeCh.
- the acne treatment active comprising at least one beta hydroxy acid is present in the composition in a range from about 0.1% to about 2%, by weight, based on the total weight of the composition.
- the at least one beta hydroxy acid is salicylic acid.
- the composition has a pH that is in the range from about 3 to about 7, or from about 3 to about 5, or from about 3 to about 4, or from about 4 to about 5.
- the composition includes one or more salts, for example, the composition may include one or more salts selected from, but not limited to, sodium chloride, calcium chloride, potassium chloride, magnesium sulfate, magnesium carbonate, calcium carbonate, and zinc pyrrolidone carboxylic acid.
- the one or more salts when present, are present in the composition in a range from about 0.01% to about 2%, by weight, based on the total weight of the composition.
- the at least one cationic polymer is a cationic nature-based polymer selected from polysaccharides.
- the at least one cationic polymer is selected from chitosan, cationic guar, guar gum, guar hydroxypropyltrimonium chloride, hydroxypropyl guar, acacia Senegal gum, Caesalpinia spinosa gum, agar, carob gum, carrageenan, carrageenan (lambda, iota kappa), cellulose gum, corn starch modified, dehydroxanthan gum, gellan gum, gum acacia, gum arabic, gum ghatti, gum karaya, gum tragacanth, hydroxypropyl methyl cellulose, lecithin, microcrystalline cellulose, pectin, potato starch modified, pullulan, sclerotium gum, sodium carboxymethyl starch, sorbitol
- the at least one nature based polymer is selected from chitosan and cationic guar. In some embodiments, the at least one nature based polymer includes only chitosan or only cationic guar. In some embodiments, the at least one nature based polymer includes a combination of chitosan with one or more of cationic guar or another cationic form of guar. In some embodiments, the at least one cationic polymer is a synthetic cationic polymer selected from the group consisting of polyquaterniums, cationic acrylic polymers, and combinations thereof.
- the at least one cationic polymer is selected from the group consisting of chitosan, cationic guar, an amorphous functional acrylic polymer grafted onto a polyethylene backbone, polyquaternium-47, and combinations thereof.
- each of the at least one cationic polymer is present in an amount that ranges from about 0.1% to about 0.5% by weight.
- the composition includes at least one surfactant selected from the group consisting of nonionic surfactants, cationic surfactants, anionic surfactants, amphoteric surfactants, and combinations thereof. In some embodiments the composition includes a combination of amphoteric, nonionic, and anionic surfactants.
- the composition includes a combination of amphoteric, nonionic, and anionic surfactants comprising Coco Betaine, Glyceryl Stearate, PEG-150 Distearate, and Sodium Methyl Cocoyl Taurate.
- each of the at least one surfactant is present in an amount that ranges from about 0.1% to about 20% by weight.
- the composition includes one or more of other optional ingredients selected from the group consisting of skin care actives, humectants, conditioning agents, thickeners, viscosity adjusters, cooling agents, fillers, antimicrobials, preservatives, pH adjusters, chelating agents, and combinations thereof.
- the composition includes a blend of humectants, antimicrobials, preservatives, actives, pH adjusters and chelating agents comprising C12-15 alkyl lactate and C12-15 alcohols, citric acid, trisodium ethylenediamine disuccinate, phenoxyethanol, caprylyl glycol, chlorphenesin, ammonium polyacryloyldimethyl taurate, propylene glycol and PEG-55 propylene glycol oleate, and kaolin.
- the disclosure provides a method for delivering to skin a cleansing composition capable of depositing salicylic acid for persistent retention on the skin after rinsing, the composition comprising: at least one beta hydroxy acid selected from -n- octanoylsalicylic acid, salicylate, sodium salicylate, willow extract, beta hydroxybutanoic acid, tropic acid, and trethocanic acid, and a aqueous carrier comprising: at least one cationic polymer, particularly a nature-based polymer selected from cationic polysaccharides; a blend of surfactants; and water; and, wherein the cosmetic composition is applied to skin that is prone to acne, followed by washing or scrubbing, optionally with a provided brush or other applicator, followed by rinsing.
- a cleansing composition capable of depositing salicylic acid for persistent retention on the skin after rinsing
- the composition comprising: at least one beta hydroxy acid selected from -n- octanoy
- Use of the cosmetic cleansing composition for treatment of skin conditions such as acne is characterized by deposition and retention on the skin after rinsing of the beta hydroxy acid, for example, salicylic acid, in an amount representing about 60% to about 250% as compared with an amount deposited with a composition that lacks the one or more cationic polymers, wherein the deposition and enhanced salicylic acid retention may be demonstrated by measurement of color change resulting from complex formation between the acid and a metal salt, such as FeCh.
- the beta hydroxy acid for example, salicylic acid
- cleaning can be any cosmetic composition utilized for application to a keratinous tissue for cleansing the skin, removal of make-up and the like.
- Nature-based means and refers to cosmetically acceptable materials and components that are one or more of directly obtained from nature, are obtained from nature with minimal processing, and are derivatives of materials that are obtained from nature.
- Cosmetic compositions according to the instant disclosure are in some embodiments up to 99.11% natural.
- Skin as used herein includes skin materials containing keratin such as facial and body skin, scalp, eyebrows, and lips.
- stable disposition of an acne treatment active means deposition, for example, beta hydroxy acid, on the skin that is resistant to removal by rinsing and/or use of a cleansing apparatus, such as a cleansing brush.
- the cosmetic composition can comprise, consist of, or consist essentially of the essential elements and limitations of the invention described herein, as well as any additional or optional ingredients, components, or limitations described herein or otherwise useful.
- the cosmetic composition may be formulated as a cleanser, as described herein, for cleansing the skin in a rinse-off formulation that provides a stable disposition of an acne treatment active, for example, beta hydroxy acid, on the skin that is resistant to removal by rinsing and/or use of a cleansing apparatus, such as a cleansing brush.
- an acne treatment active for example, beta hydroxy acid
- a cleansing apparatus such as a cleansing brush.
- the retention of salicylic acid on the skin even beyond cleansing with our without a cleansing brush effectively extends the duration of the salicylic acid availability on the skin for addressing acne and other skin conditions that are responsive to salicylic acid and other beta hydroxy acids, thereby providing sustained treatment in an otherwise rinsible formulation.
- the inventive composition includes at least one or a combination of cationic polymers.
- the acne treatment active is salicylic acid.
- the cosmetic composition overcomes shortcomings in the art pertinent to salicylic acid induced instability in cosmetic compositions.
- the composition demonstrates deposition and retention of beta hydroxy acid, after rinsing, that may be shown by measurement of color change resulting from complex formation between the acid and a metal salt, such as FeCh.
- the deposition and enhanced salicylic acid retention was demonstrated herein in the in vitro tests by measurement of color change resulting from complex formation between the acid and a metal salt, such as FeCh.
- the composition when applied to a keratinous tissue demonstrates deposition and retention of the beta hydroxy acid on the keratinous tissue after rinsing with water in an amount representing about 60% to about 250% as compared with an amount deposited with a composition that lacks the one or more cationic polymers, wherein the deposition and enhanced salicylic acid retention may be demonstrated by measurement of color change resulting from complex formation between the acid and a metal salt, such as FeCh. .
- a metal salt such as FeCh.
- the cosmetic composition is suitable for application to keratinous tissue for cleansing, particularly for addressing acne.
- the cosmetic composition is free of, or substantially free of, or devoid of one or more of oils, silicones, and film formers.
- the composition may comprise any one or more of ingredients comprising oils, silicone oils, silicone polymers, and film formers.
- the cosmetic composition comprises at least one acne treatment active comprising beta hydroxy acid.
- the composition includes a beta hydroxy acid comprising salicylic acid.
- the composition includes salicylic acid present in the cosmetic composition in an amount that ranges from about 0.2 % to about 2% by weight, based on the total weight of the composition.
- beta-hydroxy acid is understood to mean, according to the present invention, a carboxylic acid having a hydroxyl functional group and a carboxylic functional group separated by two carbon atoms.
- a beta hydroxy acid can be present in the cosmetic composition in the form of the free acid and/or in the form of one of its associated salts (salts with an organic base or an alkali metal, in particular), especially according to the final pH imposed on the composition.
- the beta hydroxy acid is selected from one or more of salicylic acid and derivatives thereof (including 5-n-octanoylsalicylic acid, salicylate, sodium salicylate, and willow extract), capryloyl salicylic acid, beta hydroxybutanoic acid, tropic acid, and trethocanic acid.
- the total amount of beta hydroxy acid includes, in some particular embodiments, from about 0.1% up to and not more than about 2% of beta hydroxy acid, by weight, based on the total weight of the cosmetic composition. In some embodiments, the cosmetic composition includes and up to and not more than about 2%, or about 1.9% of beta hydroxy acid. In some embodiments, the cosmetic composition includes from about 0.1% to about 1% of beta hydroxy acid. In some embodiments, the cosmetic composition includes and up to and not more than about 1% of beta hydroxy acid. In some embodiments, the cosmetic composition includes more than about 2% beta hydroxy acid.
- the amount of beta-hydroxy acid present in the compositions is in the range from about 0.1% to about 2%, and in some embodiments from about 0.1% to about 1.5%, and in some embodiments from about 0.1% to about 1%, including increments and all ranges and subranges therein and there between, by weight, based on the total weight of the composition.
- the amount of beta-hydroxy acid present in the compositions is in the range from about 0.1% to about 2%, and in some embodiments from about 0.1% to about 1.5%, and in some embodiments from about 0.1% to about 1%, including increments and all ranges and subranges therein and there between, by weight, based on the total weight of the composition.
- the at least one beta hydroxy acid is present in the cosmetic composition from about 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, to about 2.0 weight percent, including increments and all ranges and subranges therein and there between.
- the cosmetic composition comprises at least one cationic polymer selected from nature-based polymers that are polysaccharides, and other natural (i.e., plant, animal, or bacterial based), synthetic, or modified cationic nature-based or synthetic polymers.
- the cationic polymer is a nature-based polymer.
- a cationic nature-based polymer may be selected from cationic forms and cationic derivatives of polysaccharides isolated from algae, polysaccharides produced by microorganisms, and polysaccharides from higher plants, such as homogeneous polysaccharides.
- cationic nature-based polymer selected from polysaccharides may be chosen from polysaccharides that include chitosan, chitin, starches, alginates, celluloses, galactomannans such as guar gums, particularly cationic derivatives thereof, and combinations thereof.
- the at least one cationic nature-based polymer selected from polysaccharides may be chosen from chitosan, chitosan derivatives, chitin, starch, starch derivatives, cellulose (for example, but not limited to, ethylcellulose, nitrocellulose, hemicellulose, and hemicellulose derivatives), alginates, including but not limited to, sodium alginate, and combinations thereof.
- each of the at least one cationic nature-based polymer selected from polysaccharides may be chosen from chitosan and galactomannans such as guar gums, particularly cationic derivatives thereof.
- cationic nature-based polymer selected from polysaccharides may be chosen from one or more of methylcelluloses, hydroxyalkylcelluloses, ethylhydroxyethylcelluloses and carboxymethylcelluloses, mannans, xylans, lignins, arabans, galacturonans, alginate-based compounds, chitin, glucuronoxylans, arabinoxylans, xyloglucans, glucomannans, fructosans such as inulin, pectic acids and pectins, arabinogalactans, agars, glycosaminoglycans, gum arabics, tragacanth gums, ghatti gums, karaya gums, locust bean gums, biopolysaccharide gums of microbial origin such as scleroglucan or xanthan gums, mucopolysaccharides, chondroitin sulfates
- the amount of each of the at least one cationic nature-based polymer present in the compositions can range from about 0.01% to about 10%, or from about 0.01% to about 5%, or from about 0.01% to about 0.5%, or from about 0.1% to about 0.5%, or from about 0.1% to about 0.2%, or from about 0.1% to about 5% or from about 1% to about 3.5% or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
- One of ordinary skill in the art will appreciate that other ranges are within the scope of the invention.
- the total amount of cationic naturebased polymer that may be present in the composition can range from about 0.01% to about 20%, or from about 0.05% to about 10%, or from about 0.1% to about 5%, or from about 0.05% to about 1%, or from about 0.01% to about 0.5%, or from about 0.1% to about 0.5%, or from about 0.1% to about 0.2%, or about 0.2% or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
- One of ordinary skill in the art will appreciate that other ranges are within the scope of the invention.
- any one of the at least cationic nature-based polymer, when present, is present, by weight, based on the total weight of the composition, from about 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, 4, 5, 6, 7, 8, 9, to about 10 weight percent, including increments and ranges therein and there between.
- the cationic polymer is not a nature-based polymer and may be selected from synthetic polymers.
- the synthetic polymers are non-silicone based, and in some embodiments may be selected from the group consisting of polyquaterniums, that is polymers having quaternary ammonium centers in the polymer, for example, including polyquaternium-47 (1-Propanaminium, N,N,N-trimethyi-3-[(2-methyl-l-oxo- 2-propenyl)aminoj-, chloride, polymer with methyl 2-propenoate and 2-propenoic acid).
- polyquaternium compounds may be selected from diallyidimethylammonium chloride/acrylic acid copolymers sold under the names MERQUAT 280 POLYMER or MERQUAT 280NP POLYMER or MERQUAT 281 POLYMER or MERQUAT 295
- POLYMER by the company Nalco (Lubrizol) (INCI name: Polyquaternium-22); the copolymer of methacrylamidopropyltrimonium chloride, of acrylic acid and or methyl acrylate, sold under the name MERQUAT 2001 POLYMER OR MERQUAT 2001N POLYMER by the company Nalco (Lubrizol) (INCI name: Polyquaternium-47); the acrylamide/dimethyldiallylammonium chloride/acrylic acid terpolymer sold under the name MERQUAT 3330DRY POLYMER or MERQUAT 3330PR POLYMER or MERQUAT 3331PR POLYMER or MERQUAT 3940 POLYMER or MERQUAT PLUS 3330
- Polyquaternium-39 an ampholytic terpolymer consisting of methacrylamidopropyl trimethyl ammonium chloride (MAPTAC), acrylamide and acrylic acid, sold under the name MERQUAT
- the cationic polymer is a synthetic polymer selected from cationic acrylic polymers, for example, an amorphous functional acrylic polymer grafted onto a polyethylene backbone such as SYNTRAN (TM) 5330, which is a quaternary modified olefin grafted technology. More generally, such synthetic polymers selected from, but are not limited to, cationic polymers comprising polyacrylates such as those identified in the International Cosmetic Ingredient Dictionary and Handbook (9 th ed.
- Such (co)polymers, or similar (co)polymers can be combined individually or with other (co)polymers in such a way to form suitable bimodal agents having both cationic and anionic functionalities.
- the amount of cationic polymer is not a nature-based polymer and is selected from synthetic cationic polymers that may be present in the composition can range from about 0.01% to about 20%, or from about 0.05% to about 10%, or from about 0.1% to about 5%, or from about 0.5% to about 2%, or about 1%, or from about 0.05% to about 1%, or from about 0.01% to about 0.5%, or from about 0.1% to about 0.5%, or from about 0.1% to about 0.2% or any suitable combination, sub-combination, range, or subrange thereof by weight, based on the weight of the composition.
- any one of the at least synthetic cationic polymer, when present, is present, by weight, based on the total weight of the composition, from about 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, 4, 5, 6, 7, 8, 9, to about 10 weight percent, including increments and ranges therein and there between.
- the amount of each of the at least one cationic polymer which may be either nature-based or synthetic cationic polymer, alone or in combination with another cationic polymer, present in the compositions can range from about 0.01% to about 10%, or from about 0.01% to about 5%, or from about 0.01% to about 0.5%, or from about 0.1% to about 0.5%, or from about 0.1% to about 0.2%, or from about 0.1% to about 5% or from about l%to about 3.5%, or from about 0.5% to about 2%, or about 1%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
- One of ordinary skill in the art will appreciate that other ranges are within the scope of the invention.
- the composition may include one or more salts, for example, the composition may include one or more salts selected from sodium chloride, calcium chloride, potassium chloride, magnesium sulfate, magnesium carbonate, calcium carbonate, and zinc pyrrolidone carboxylic acid, and other suitable mineral salts of sodium, calcium, magnesium, potassium, zinc, and the like.
- the amount of each of the one or more salts, when present, is in a range from about 0.01% to about 5%, or from about 0.01% to about 1%, or from about 0.01% to about 0.5%, or from about 0.1% to about 0.5%, or from about 0.1% to about 0.2%, or about 0.2%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
- a range from about 0.01% to about 5%, or from about 0.01% to about 1%, or from about 0.01% to about 0.5%, or from about 0.1% to about 0.5%, or from about 0.1% to about 0.2%, or about 0.2%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
- any one of the added salts when present, is present, by weight, based on the total weight of the composition, from about 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, 4, to about 5 weight percent, including increments and ranges therein and there between.
- the cosmetic composition comprises at least one surfactant.
- the cosmetic composition comprises more than one surfactant.
- the at least one surfactant may be an nonionic, cationic, anionic, or an amphoteric or zwitterionic surfactant.
- the composition includes one or a combination of surfactants selected from the group consisting of amphoteric, nonionic, anionic surfactants and combinations thereof.
- the amphoteric surfactant may include coco betaine
- the nonionic surfactant may include glyceryl stearate or PEG-150 distearate or a combination thereof
- the anionic surfactant may include sodium methyl cocoyl taurate.
- the composition includes the combination of surfactants that comprise coco betaine, glyceryl stearate, PEG-150 distearate, and sodium methyl cocoyl taurate.
- the composition includes one or a combination of surfactants that include surfactants selected from the group consisting of amphoteric, nonionic, anionic surfactants and combinations thereof.
- the amphoteric surfactant may include Cocamidopropyl Hydroxysultaine
- the nonionic surfactants may include PEG-150 Pentaerythrityl Tetrastearate
- the anionic surfactants may include Sodium Lauroyl Sarcosinate or Sodium Methyl Cocoyl Taurate or a combination thereof.
- the composition includes the combination of surfactants that comprise Cocamidopropyl Hydroxysultaine, PEG-150 Pentaerythrityl Tetrastearate, Sodium Lauroyl Sarcosinate, and Sodium Methyl Cocoyl Taurate.
- surfactants that comprise Cocamidopropyl Hydroxysultaine, PEG-150 Pentaerythrityl Tetrastearate, Sodium Lauroyl Sarcosinate, and Sodium Methyl Cocoyl Taurate.
- the composition includes one or a combination of surfactants that include surfactants selected from the group consisting of amphoteric, nonionic, anionic surfactants and combinations thereof.
- the amphoteric surfactant may include Coco Betaine
- the nonionic surfactants may include Decyl Glucoside or PEG-150 Pentaerythrityl Tetrastearate or PEG-6 Caprylic/Capric Glycerides or a combination thereof
- the anionic surfactants may include Sodium Laureth Sulfate.
- the composition includes the combination of surfactants that comprise Coco Betaine, Decyl Glucoside, PEG-150 Pentaerythrityl Tetrastearate, PEG-6 Caprylic/Capric Glycerides and Sodium Laureth Sulfate.
- surfactants that comprise Coco Betaine, Decyl Glucoside, PEG-150 Pentaerythrityl Tetrastearate, PEG-6 Caprylic/Capric Glycerides and Sodium Laureth Sulfate.
- the at least one surfactant may be selected from the group consisting of cocamidopropyl hydroxysultaine, sodium lauroyl sarcosinate, sodium methyl cocoyl taurate (and) sodium chloride (and) coconut acid, PEG-150 distearate, PEG- 150 pentaerythrityl tetrastearate and combinations thereof.
- the composition comprises more than one or all of the surfactants selected from the group consisting of cocamidopropyl hydroxysultaine, sodium lauroyl sarcosinate, sodium methyl cocoyl taurate (and) sodium chloride (and) coconut acid, PEG-150 distearate, PEG-150 pentaerythrityl tetrastearate and combinations thereof.
- the surfactants selected from the group consisting of cocamidopropyl hydroxysultaine, sodium lauroyl sarcosinate, sodium methyl cocoyl taurate (and) sodium chloride (and) coconut acid, PEG-150 distearate, PEG-150 pentaerythrityl tetrastearate and combinations thereof.
- the at least one surfactant may be selected from the group consisting of polyoxyethylene sorbitan monolaureate, laureth-23, polyoxyethylated octyl phenol, 3-((3-cholamidopropyl) dimethylammonio)-l propane sulfonate, sodium dilauramidoglutamide lysine, cholate, deoxycholate, sodium dodecylsulfate, TWEEN-80, and combinations thereof.
- the at least one surfactant may exclude esters.
- the at least one surfactant may be present in the composition in a range from about 1% to about 5%, based on the weight of the composition.
- the at least one surfactant may be selected from the group consisting of surfactants with a C10-C20 fatty alcohol or acid hydrophobe condensed with from about 2 to about 100 moles of ethylene oxide or propylene oxide per mole of hydrophobe; C2- CIO alkyl phenols condensed with from 2 to 20 moles of alkylene oxide; mono- and di-fatty acid esters of ethylene glycol; fatty acid monoglyceride; sorbitan; mono- and di- C8-C20 fatty acids; polyoxyethylene sorbitan; alkyl polyglycosides and saccharide fatty amides (e.g.
- alkyl ether sulfate and sulfonates alkyl sulfates and sulfonates; alkylbenzene sulfonates; alkyl and dialkyl sulfosuccinates; C8-C20 acyl isethionates; C8-C20 alkyl ether phosphates; alkylethercarboxylate and combinations thereof.
- the at least one surfactant may be selected from the group consisting of PEG-100 Stearate; PEG-20 Stearate and other esters of PolyfEthylene Glycol); Sucrose Stearate and other emulsifiers based on sugar esters; Glyceryl Stearate and other glycerol esters; Disodium Ethylene Dicocamide PEG-15 Disulfate; Sodium Steroyl Glutamate and other fatty amides; Steareth-100 and other fatty ethers sodium C14-16 olefin sulfonate, disodium laureth sulfosuccinate (and) sodium lauryl sulfoacetate, sodium lauroyl sarcosinate, sodium methyl cocoyl taurate, sodium methyl lauroyl taurate, sodium cocoyl alaninate, sodium cocoyl isethionate, cocamidopropyl hydroxysultaine, cocamidopropyl be
- each of the at least one surfactant may be present in an amount in the range of from about 0.1% to about 20%, and the total amount of surfactant may be present in a range from about 0.1% to about 40% or more.
- each of the at least one surfactant when present, is present in an amount that is at least 0.1%, or about 1%, to about 20%, or up to 20%, or about 0.1% to about 5%, or to about 3% or to about 8%, or from about 5% to about 10%, or from about 7% to about 15%, or from about 10% to about 30%, or about 30% to about 50%, or any value, range, or sub-range therebetween by weight, based on the weight of the composition.
- each of the at least one surfactant may be present in a composition according to the disclosure from 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 120, 21, 22, 23, 24, 25, 26, 27,28,29, 30, 3, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 to about 50 percent, including increments and ranges therein and there between.
- the cosmetic composition includes water.
- the cosmetic composition comprises from about 5% to about 90% water, and in some embodiments from about 20% to about 85% water, and in some embodiments from about 50% to about 85% water, and in some embodiments from about 60% to about 80% water, and in some embodiments from about 65% to about 75%, water, including increments and all ranges and subranges therein and there between, by weight, based on the total weight of the composition.
- the cosmetic composition comprises from about 5% to about 90% water, and in some embodiments from about 20% to about 85% water, and in some embodiments from about 50% to about 85% water, and in some embodiments from about 60% to about 80% water, and in some embodiments from about 65% to about 75%, water, including increments and all ranges and subranges therein and there between, by weight, based on the total weight of the composition.
- water is present, by weight, based on the total weight of the composition, from about 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 80, 85, to about 90 weight percent, including increments and all ranges and subranges therein and there between.
- the water used in the cosmetic composition may be sterile demineralized water and/or a floral water such as rose water, cornflower water, chamomile water or lime water, and/or a natural thermal or mineral water such as, for example: water from Vittel, water from the Vichy basin, water from Uriage, water from La Roche Posay, water from La Bourboule, water from Enghien-les-Bains, water from Saint Gervais-les-Bains, water from Neris-les-Bains, water from Allevar-les-Bains, water from Digne, water from Maizieres, water from Neyrac-les-Bains, water from Lons-le-Saunier, water from Eaux Bonnes, water from Rochefort, water from Saint Christau, water from Les Fumades, water from Tercis-les-Bains or water from Avene.
- the water phase may also comprise reconstituted thermal water, that is to say a water comprising trace elements such as zinc, copper, magnesium, etc., reconstituting the
- the pH of the cosmetic composition is in the range from about 3 to about 7, or from about 3 to about 5, or from about 3 to about 4, or from about 4 to about 5.
- the pH can be adjusted to the desired value by addition of a base or an acid (organic or inorganic).
- the pH is typically adjusted using a base, which in some examples is sodium hydroxide, or using an acid, which in some examples is citric acid.
- the cleansing composition may include at least one water-soluble solvent.
- water-soluble solvent is interchangeable with the term “water-miscible solvent” and means a compound that is liquid at 25 9 C and at atmospheric pressure (760 mmHg), and it has a solubility of at least 50% in water under these conditions.
- the water-soluble solvent has a solubility of at least 60%, 70%, 80%, or 90% in water under these conditions.
- Non-limiting examples of water-soluble solvents include, for example, glycerin, alcohols (for example, C1-C30, C1-C15, C1-C10, or C1-C4 alcohols), polyols, glycols, and combinations thereof.
- organic solvents non-limiting mentions can be made of monoalcohols and polyols such as ethyl alcohol, isopropyl alcohol, propyl alcohol, benzyl alcohol, and phenylethyl alcohol, or glycols or glycol ethers such as, for example, monomethyl, monoethyl and monobutyl ethers of ethylene glycol, propylene glycol or ethers thereof such as, for example, monomethyl ether of propylene glycol, butylene glycol, hexylene glycol, dipropylene glycol as well as alkyl ethers of diethylene glycol, for example monoethyl ether or monobutyl ether of diethylene glycol.
- organic solvents are ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, propane diol, and glycerin.
- the organic solvents can be volatile or non-volatile compounds.
- water-soluble solvents include alkanols (polyhydric alcohols such as glycols and polyols) such as glycerin, 1,2,6-hexanetriol, trimethylolpropane, ethylene glycol, propylene glycol, diethylene glycol, butylene glycol, hexylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol, dipropylene glycol, 1,3-butanediol, 2,3- butanediol, 1,4-butanediol, 3-methyl-l,3-butanediol, 1,5-pentanediol, tetraethylene glycol, 1,6- hexanediol, 2-methyl-2,4-pentanediol, polyethylene glycol, 1,2,4-butanetriol, 1,2,6-hexanetriol, 2-butene-l,4-diol,
- a water-soluble solvent may be selected from the group consisting of one or more glycols, Cl-4 alcohols, glycerin, and combinations thereof.
- total amount of the at least one water- soluble solvent when present, may vary, is from about 0.5% to about 25%, or from about 0.5% to about 20%, or from about 1% to about 20%, or from about 1% to about 10%, or from about 2% to about 5% or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
- total amount of the at least one water- soluble solvent when present, may vary, is from about 0.5% to about 25%, or from about 0.5% to about 20%, or from about 1% to about 20%, or from about 1% to about 10%, or from about 2% to about 5% or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
- any one water-soluble solvent when present, is present, by weight, based on the total weight of the composition, from about 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24 to about 25 weight percent, including increments and ranges therein and there between.
- the humectant may comprise one or more of polyols, including, for example, glycerin, glycerol, glycols, such as, caprylyl glycol, butylene glycol, propylene glycol, isoprene glycol, dipropylene glycol, hexylene glycol and polyethylene glycols, monoethylene glycol, diethylene glycol, triethylene glycol, diethylene glycol, hexylene glycol, glycol ethers, such as, monopropylene, dipropylene and tripropylene glycol alkyl(Cl-C4)ethers, squalane, triacetin, sugars, such as, glucose, xylitol, maltitol, sorbitol, sucrose pentaerythritol, inositol, pyrrolidone carboxylic acid, lactic
- polyols including, for example, glycerin, glycerol, glycols, such as, cap
- the amount of humectant or conditioning agent present in the composition can range from about 1% to about 10%, or from about 1% to about 8%, or from about 1% to about 5%, or from about 2% to about 3%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
- the amount of humectant or conditioning agent present in the composition can range from about 1% to about 10%, or from about 1% to about 8%, or from about 1% to about 5%, or from about 2% to about 3%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
- any one of or a combination of humectant, when present, may be present, by weight, based on the total weight of the composition, is from about 1, 2, 3, 4, 5, 6, 7, 8, 9, to about 10 weight percent, including increments and ranges therein and there between.
- one or more preservatives and/or antimicrobials may be present in the composition.
- Any preservative commonly used in cosmetic cleansing compositions is an acceptable preservative for the cleansing compositions herein, such as phenoxyethanol, members from the paraben family such as the methyl, ethyl, propyl, butyl or isobutyl parabens, 4-hydroxy benzoic acid, benzoic acid, sorbic acid, dehydroacetic acid, triclosan, benzyl alcohol, chlorophenesin, or salicylic acid, for example.
- suitable solvents for optional additives in particular, suitable solvents for antimicrobials and preservatives, members from the paraben family may be used as a preservative.
- the preservative may comprise one or more of preservatives selected from the group consisting of organic acids, parabens, formaldehyde donors, phenol derivatives, quaternary ammoniums, alcohols, isothiazolinones, and combinations thereof.
- Preservatives having antibacterial activity are optionally present in the cleansing compositions of the present invention.
- organic acid preservatives include, but are not limited to, sodium benzoate, potassium sorbate, benzoic acid and dehydroacetic acid, sorbic acid, and combinations thereof.
- a preferred organic acid preservative system includes a mixture of sodium benzoate and potassium sorbate.
- paraben preservatives include, but are not limited to, alkyl para-hydroxybenzoates, wherein the alkyl radical has from 1, 2, 3, 4, 5 or 6 carbon atoms and for example, from 1 to 4 carbon atoms e.g., methyl para-hydroxybenzoate (methylparaben), ethyl para-hydroxybenzoate (ethylparaben), propyl para-hydroxybenzoate (propylparaben), butyl para-hydroxybenzoate (butylparaben) and isobutyl para-hydroxybenzoate (isobutylparaben).
- alkyl para-hydroxybenzoates wherein the alkyl radical has from 1, 2, 3, 4, 5 or 6 carbon atoms and for example, from 1 to 4 carbon atoms e.g., methyl para-hydroxybenzoate (methylparaben), ethyl para-hydroxybenzoate (ethylparaben), propyl para-hydroxybenzoate (propylparaben), but
- formaldehyde donor preservatives include, but are not limited to, l,3-Dimethylol-5,5-dimethylhydantoin (DMDM hydantoin), imidazolidinyl urea, gluteraldehyde, and combinations thereof.
- quaternary ammonium preservatives include, but are not limited to, benzalkonium chloride, methene ammonium chloride, benzethonium chloride, and combinations thereof.
- alcohol preservatives include, but are not limited to, ethanol, benzyl alcohol, dichlorobenzyl alcohol, phenoxyethanol, and combinations thereof.
- isothiazolone preservatives include, but are not limited to, methylchloroisothiazolinone, methylisothiazolinone, and combinations thereof.
- appropriate preservatives include, but are not limited to, phenoxyethanol, Tetrasodium EDTA, Zinc Gluconate, Hydroxyacetophenone, Caprylyl glycol, Chlorphenesin, or combinations thereof.
- the preservative includes one or more preservatives, the one or combination present at a concentration, by weight of about 0.001% to about 5%, or alternatively about 0.05% to about 2.5% or alternatively about 0.1% to about 2.0%, based upon weight of the composition.
- concentration by weight of about 0.001% to about 5%, or alternatively about 0.05% to about 2.5% or alternatively about 0.1% to about 2.0%, based upon weight of the composition.
- any one of or a combination of preservatives, when present, may be present, by weight, based on the total weight of the composition, is from about 0.001, 0.002, 0.003 ,0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.01, 0.02, 0.03 ,0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 3, 4, to about 5 weight percent, including increments and ranges therein and there between.
- the composition includes one or more of other optional ingredients selected from the group consisting of skin care actives, humectants, conditioning agents, thickeners, viscosity adjusters, cooling agents, fillers, antimicrobials, preservatives, pH adjusters, chelating agents, and combinations thereof.
- a cleansing composition includes at least one additive used in the cosmetics field which does not affect the properties of the composition according to the invention, such as, fragrances, pH adjusters (citric acid, sodium chloride, lactic acid); neutralizing or pH-adjusting agents (e.g., triethylamine (TEA) and sodium hydroxide, Trisodium ethylenediamine disuccinate, and combinations thereof), other cosmetically acceptable additives, such as but not limited to, pearlescent agents, silica, and coloring materials; essential oils; fruit extracts, for example, Pyrus Malus (Apple) Fruit Extract, and Aloe Barbadensis Leaf Juice Powder; conditioning agents such as C12-15 Alkyl lactate and C12-15 Alcohols; Thickeners, for example Ammonium polyacryloyldimethyl taurate, Propylene glycol and PEG-55 propylene glycol oleate; viscosity adjusters, for example, Sodium chloride and Hexylene Glycol; cooling agents such as
- the composition includes a blend of humectants, antimicrobials, preservatives, actives, pH adjusters and chelating agents comprising C12-15 Alkyl lactate and C12-15 Alcohols, citric acid, trisodium ethylenediamine disuccinate, phenoxyethanol, caprylyl glycol, chlorphenesin, ammonium polyacryloyldimethyl taurate, propylene glycol and PEG-55 propylene glycol oleate, and kaolin.
- the amount of one or more additives, alone or in combination, present in the composition can be present in the composition according to the disclosure in a range from about 0.001% to about 20%, by weight, or from about 0.005% to about 0.01%, or from about 0.01% to about 0.1%, or from about 0.15% to about 5%, or from about 0.40% to about 4%, or from about 0.5% to about 2.5% by weight, or from about 1% to about 2%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the total weight of the composition.
- One of ordinary skill in the art will appreciate that other ranges are within the scope of the invention.
- any one or a combination of additives may be present, by weight, based on the total weight of the composition, each one or the combination present from about 0.001, 0.002, 0.003, 0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80, 0.90, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 to about 20 weight percent, including increments and ranges therein and there between.
- optional additives are given as examples, it will be appreciated that other optional components compatible with cosmetic applications known in the art may be used that are suitable. It will be appreciated by a skilled artisan that any optional additives are present only to the extent and in amounts that do not materially adversely affect the basic and novel characteristic(s) of the claimed disclosure. Thus, in some embodiments that include optional additives, such optional additives will not materially adversely affect the composition.
- Embodiments of the inventive cleanser composition were prepared using one the exemplified base compositions and are further described herein below. It will be appreciated that the exemplified base compositions are not limiting, and that yet other embodiments of the inventive cleanser composition may be prepared in accordance with the scope of the disclosure and may include the same or other ingredients that do not materially adversely affect the basic and novel characteristics of the claimed invention.
- Inventive Compositions were prepared with the exemplified BASE 3 plus a cationic polymer, as shown in these examples, chosen from Syntran PC 5330* ("Syntran”), Chitosan, Cationic Guar (“Guar”), and Polyquaternium-47** ("PQ-47"). Specific examples of Inventive Compositions that include one of these exemplified cationic polymers are shown below in Table 5.
- Inventive Compositions were prepared with the bases BASE 1 and BASE 2, + a cationic polymer, as shown in these examples, chosen from Syntran, Chitosan, Cationic Guar, and
- Comparative Compositions include the above listed BASE 1 and BASE 2 compositions and were prepared with addition of water. The Comparative Compositions and are shown below in Table 7.
- compositions were evaluated for demonstration of salicylic acid deposition on a synthetic skin material after application of the various tested compositions.
- the test set up is shown below.
- BIOSKIN samples of about 2 in by 2 inches were provides. Each bioskin sample was treated with one of an inventive, example and comparative composition by application of about 0.5 g of the tested composition with a cleansing brush (Clarisonic (TM) brush). Cleansed samples were soaked in water for about 30 seconds, then massaged using the cleansing brush for about one minute. The samples were then rinsed under water at forty degrees C then air dried for about an hour. Samples were then soaked in a solution of iron chloride (0.01% FeCIs) for about an hour then air dried overnight.
- TM cleansing brush
- Comparative compositions that did not include any cationic polymer demonstrated the lowest amount of post-rinse deposited salicylic acid.
- each of the Inventive compositions that included one of the exemplified cationic polymers selected from Syntran, Chitosan, Cationic Guar, and Polyquaternium-47 demonstrated significantly increased post-rinse deposited salicylic acid. While these results are obtained with the specifically exemplified cationic polymers, the invention includes other embodiments of cationic polymers and combinations thereof according to the disclosure that would be contemplated to provide the same or comparable deposition of salicylic acid.
- compositions according to the disclosure confer deposition and retention of the beta hydroxy acid, after rinsing, in a range from about 50% to about 250% greater, or more, than the deposition and retention, after rinsing, that is obtained by a similar composition that lacks a cationic polymer.
- the relative increase in deposition of beta hydroxy acid, for example, salicylic acid, obtained using an inventive composition containing a cationic polymer is greater than what is obtained in the absence of cationic polymer in a range from about 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123,
- compositions were evaluated for demonstration of the effect of salt on salicylic acid deposition on a synthetic skin material after application of the various tested compositions on the BIOSKIN.
- the tested composition is shown in Table 11 and results of the effect of added salt on deposition are shown in Table 12.
- Table 12 PERCENT SALICYLIC ACID COVERAGE WITHOUT AND WITH ADDITION OF
- At least one or “one or more” as used herein means that there may be one, two, three or more and thus includes individual components as well as mixtures/combinations.
- the terms “free” and “devoid” indicates that no reliably measurable excluded material is present in the cosmetic composition, typically 0% by weight, based on the total weight of the cosmetic composition.
- the term “essentially free” means that, while it prefers that no excluded material is present in the cosmetic composition, it is possible to have very small amounts of the excluded material in the cosmetic composition of the invention, provided that these amounts do not materially affect the advantageous properties of the cosmetic composition.
- "essentially free” means that excluded material can be present in the cosmetic composition at an amount of less than about 0.1% by weight, based on the total weight of the cosmetic composition.
- weight percent of an ingredient refers to the amount of the raw material comprising the ingredient, wherein the raw material may be described herein to comprise less than and up to 100% activity of the ingredient. Therefore, weight percent of an active in a composition is represented as the amount of raw material containing the active that is used and may or may not reflect the final percentage of the active, wherein the final percentage of the active is dependent on the weight percent of active in the raw material.
- a range from 1-5 includes specifically 1, 2, 3, 4 and 5, as well as subranges such as and 2-5, 3-5, 2-3, 2-4, 1-4, etc.
- a range of ratios is meant to include every specific ratio within, and combination of subranges between the given ranges.
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CN202280012295.7A CN116940331A (en) | 2021-01-29 | 2022-01-28 | Cleansing compositions providing enhanced salicylic acid deposition for acne treatment |
EP22702052.6A EP4284328A2 (en) | 2021-01-29 | 2022-01-28 | Cleansing composition providing enhanced deposition of salicylic acid for acne treatment |
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US17/162,392 US20220249341A1 (en) | 2021-01-29 | 2021-01-29 | Cleansing composition providing enhanced deposition of salicylic acid for acne treatment |
US17/162,392 | 2021-01-29 | ||
FR2104695A FR3122576B1 (en) | 2021-05-04 | 2021-05-04 | CLEANSING COMPOSITION PROVIDING AN IMPROVED SALICYLIC ACID DEPOSIT FOR THE TREATMENT OF ACNE |
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US20210093724A1 (en) * | 2019-09-30 | 2021-04-01 | Concept Matrix Solutions | Topical anti-acne composition |
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