WO2022156877A1 - Protein formulation - Google Patents
Protein formulation Download PDFInfo
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- WO2022156877A1 WO2022156877A1 PCT/EP2021/051011 EP2021051011W WO2022156877A1 WO 2022156877 A1 WO2022156877 A1 WO 2022156877A1 EP 2021051011 W EP2021051011 W EP 2021051011W WO 2022156877 A1 WO2022156877 A1 WO 2022156877A1
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- 239000000203 mixture Substances 0.000 title claims abstract description 36
- 102000004169 proteins and genes Human genes 0.000 title claims description 65
- 108090000623 proteins and genes Proteins 0.000 title claims description 65
- 238000009472 formulation Methods 0.000 title claims description 15
- 239000002537 cosmetic Substances 0.000 claims abstract description 12
- 239000000839 emulsion Substances 0.000 claims description 113
- 235000018102 proteins Nutrition 0.000 claims description 64
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- 239000006260 foam Substances 0.000 claims description 26
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- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 10
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Definitions
- the present invention belongs to the cosmetic field and relates to a cosmetic composition comprising proteins.
- a beautiful and attractive appearance is a desire for many people.
- One typical sign of such an appearance is a healthy and smooth looking skin. Therefore, in order to take care of the skin, it is for many people a daily routine to apply cosmetic products such as body lotions, sunscreens or deodorant compositions.
- the first approach involves aerosol products, in which a cosmetic composition is stored in pressurized container having a valve suitable to dispense the composition. Depending on the header located on the outer part of the valve the composition may be dispensed in form a dense foam. Looking at this approach from the environmental side, it is not ideal that the formulations has to be put into a pressurized container as this requires significant amount of energy to produce the required overpressure. Furthermore, the release of propellants such as propane and/or butane may not be in the interest of the environment.
- the second approach are products, which are converted into foam in the production process by injecting a gas into a denser formula.
- dense formula is understood as a highly viscose formula comprising considerable amounts of suitable waxes and polymers allowing air to remain within the formulation.
- the sensory is very dense and thick, and it is not possible to obtain light textures by this means.
- the polymers included are usually acrylic polymers.
- Acrylic polymers are polymers formed by homo- or copolymerization with acrylic and/or methacrylic acid.
- foamable compositions which may be converted into foam using household devices suffer a number of disadvantages.
- most foamable composition do not allow to form a foam having a light texture, which can only be obtained with compositions dispensed with propellant from aerosols.
- the foam obtained does often not have a thick, dense appearance.
- the foam is not stable for a prolonged amount of time, meaning that the foam does rapidly collapse after creating it.
- foamable compositions which allow to provide foam with a household stirrer, whereby the foam does not suffer the disadvantages discussed above.
- foamable composition which allow for a thick foam to be obtained using household mixer, whereby the foam is easy to spread and very light during the application on the skin.
- the foamable composition is environmentally acceptable, meaning that the presence of acrylic polymers is not required. Further it is desirable if the foam created is very dense, having small air bubble size, having a creamy appearance and is capable of maintaining its structure if stored at 40°C for a prolonged amount of time, without showing a water separation.
- the present invention is a cosmetic emulsion comprising, based on the total weight of the emulsion, a) at least one protein, b) at least one pH modifier, and c) an emollient system. All weight percentages (% by weight) given below relate, unless otherwise stated, to the total weight of the cosmetic emulsion. If ratios of certain components are disclosed in the following description, these ratios refer, unless otherwise stated, to weight ratios of the components.
- normal conditions refers to 20°C, 1013 hPa and a relative humidity of 50%.
- skin refers solely to human skin.
- a further object of the present invention is the use of an emulsion according to the invention to provide foam upon stirring the emulsion.
- a further object of the invention is a method of providing foam by providing an emulsion according to the invention and consecutively suspending air in the emulsion, preferably by mechanically stirring.
- emulsion according to the invention allowed to create a foam as required, while no foam was observed using instead of proteins hydrolyzed proteins or fragmented proteins.
- Hydrolyzed proteins are derived from the hydrolysis of a protein into its component amino acids and peptides. Accordingly, the original protein is no more intact.
- the emulsion according to the invention is characterized in that it is an oil in water emulsion.
- the invention is characterized in that the emulsion comprises at least one protein. It is preferred if the total content of the proteins in the formulation is ideally from 0.5% to 8.0%, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion.
- the protein is a natural occurring protein.
- Fibrous proteins are linear (long fibrous) in shape. Typical examples are a-Keratin, - Keratin and Collagen. Globular proteins are spherical or globular in shape. Typical examples are a- lactalbumin, p-lactoglobulin, myoglobin and hemoglobin.
- proteins may also be classified according to their composition:
- Simple proteins are composed of only amino acids, whereby the proteins may be fibrous or globular. Typical simple proteins are bovine albumin and casein.
- Conjugate proteins are complex proteins, which contain one or more non-amino acid components. Typical examples are lipoproteins or glycoproteins.
- the at least one protein contained is characterized in that the protein is a globular protein.
- the total content of the globular protein(s) in the formulation is from 0.5% to 8.0%, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion.
- the proteins contained are characterized in that the proteins are simple proteins.
- the total content of the simple protein(s) in the formulation is from 0.5% to 8.0%, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion.
- the proteins according to the invention are simple, globular proteins. Accordingly, it is also most preferred if the emulsion comprises at least one simple, globular protein, whereby the total quantity of those proteins is preferably in the range from 0.5% to 8.0%, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion.
- proteins showed particular effective foaming properties.
- Particular preferred are the a- lactalbumin, p-lactoglobulin and/or casein; whereby a-lactalbumin and/or p-lactoglobulin are most preferred.
- a-lactalbumin, p-lactoglobulin and/or casein are contained in the emulsion according to the invention in a total quantity of from 0.5% to 8.0%, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion. It is further preferred if a-lactalbumin and/or p-lactoglobulin are contained in the emulsion according to the invention in a total quantity of from 0.5% to 8.0%, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion.
- Preferred embodiments of the invention are characterized in that the protein is chosen from the group consisting of sunflower proteins, chickpea proteins, pea proteins, lentil proteins, lupin proteins, rice protein, fava bean protein, collagen, whey protein, casein, keratin, algae derived proteins and yeast derived proteins. It is more preferred if the protein contained is whey protein and/or casein. Most preferred is whey protein.
- the proteins chosen from the group consisting of sunflower proteins, chickpea proteins, pea proteins, lentil proteins, lupin proteins, rice protein, fava bean protein, collagen, whey protein, casein, keratin, algae derived proteins and yeast derived proteins are contained in the emulsion according to the invention in a total quantity of from 0.5% to 8.0%, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion.
- proteins whey protein and/or casein are contained in the emulsion according to the invention in a total quantity of from 0.5% to 8.0%, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion.
- whey protein is contained in the emulsion according to the invention in a total quantity of from 0.5% to 8.0%, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion. Further it is preferred if no further proteins are contained.
- the emulsion comprises at least one pH modifier.
- a pH modifier is understood as, at normal conditions, a water soluble compound, which is an acid or bases. It is particular preferred if the pH modifier is an acid and/or a salt thereof.
- Preferred pH modifier used according to the invention are selected from the group of glycolic acid, lactic acid, mandelic acid, citric acid, salicylic acid, hydroxybutanoic acid, hyaluronic acid, ascorbic acid, tartaric acid, malic acid, azelaic acid, ferulic acid and salts thereof.
- citric acid tartaric acid and/or salts thereof. It is even more preferred if the pH modifier are citric acid and/or potassium acid tartrate.
- At least potassium acid tartrate is contained as pH modifier. Especially for the case that potassium acid tartrate is used, it was surprisingly noted that the foam had a prolonged stability and did not collapse.
- the total content of the pH modifier is in the range from 0.2 to 5.0% by weight, more preferably 0.5 to 3.0% by weight and most preferably 1.0 to 1.8% by weight, calculated to the total weight of the emulsion.
- citric acid is contained in the emulsion of the invention as pH modifier, it is preferred if the total quantity of citric acid is in the range from 0.1 to 2.0% by weight, more preferably 0.15 to 0.8% by weight and most preferably 0.18 to 0.6% by weight, calculated to the total weight of the emulsion.
- potassium acid tartrate is contained in the emulsion of the invention as pH modifier, it is preferred if the total quantity of potassium acid tartrate is in the range from 0.1 to 4.0% by weight, more preferably 0.5 to 2.5% by weight and most preferably 0.8 to 1.5% by weight, calculated to the total weight of the emulsion.
- the ratio between the total content of the total quantities of the protein and the total quantities of the pH modifier is in the range from 10:1 to 1:2, more preferably 8:1 to 1:1 and most preferably 3.5:1 to 2.5:1.
- the emulsion is characterized in that it comprises an emollient system.
- An emollient system comprises at least one emollient.
- Emollients are understood to be all substances which are listed in the International Cosmetic Ingredient Dictionary and Handbook, Thirteenth Edition 2010, (ISBN 1-882621-47-6) under the name "emollient”.
- Preferred emollients to be contained in the emollient system are selected from the group of cosmetic butters. It is particular preferred if cupuacu butter, murumuru butter and/or butyrospermum parkii (shea) butter are contained. It is most preferred if the emollient system comprises at least butyrospermum parkii (shea) butter. For the case that at least one cosmetic butter is contained in the emollient system it is preferred if the total quantity of the cosmetic butters is in the range from 0.5 to 20% by weight, more preferably 5% to 18% by weight and most preferred 8% to 15% by weight, calculated to the total weight of the emulsion.
- cupuacu butter, murumuru butter and/or butyrospermum parkii (shea) butter are contained in the emollient system it is preferred if the total quantity of cupuacu butter, murumuru butter and/or butyrospermum parkii (shea) butter is in the range from 0.5 to 20% by weight, more preferably 5% to 18% by weight and most preferred 8% to 15% by weight, calculated to the total weight of the emulsion.
- butyrospermum parkii (shea) butter is contained in the emollient system it is preferred if the total quantity of butyrospermum parkii (shea) butter is in the range from 0.5 to 20% by weight, more preferably 5% to 18% by weight and most preferred 8% to 15% by weight, calculated to the total weight of the emulsion.
- the ratio of oil and wax components that are liquid under normal conditions to the oil and wax components that are solid, respectively not liquid, under normal conditions is in the range from 1 :1 to 1:1000, more preferably 1:1.5 to 1 :500 and most preferably 1 :2 to 1:25.
- the emulsion comprises further an oil and/or wax component that is liquid under normal conditions it is preferred if at least one natural oil is contained.
- Preferred natural oils are selected from the list soya oil, cotton seed oil, sunflower oil, palm oil, palm kernel oil, linseed oil, almond oil, castor oil, vegetable oil, corn oil, olive oil, rapeseed oil, sesame oil, thistle oil, wheat germ oil, avocado oil, peach kernel oil and/or the liquid fractions of coconut oil. Most preferred is vegetable oil.
- the emulsion comprises further at least one fatty alcohol selected from the group of cetyl alcohol, stearyl alcohol and/or cetearyl alcohol.
- the total quantity of those fatty alcohols is in the range from 0.5 to 6% by weight, more preferably 1.5 to 5.5% by weight and most preferably from 2.2 to 4.2% by weight calculated to the total weight of the emulsion.
- preferred emulsions according to the invention are characterized in that the emulsion comprises an outer aqueous phase and an inner oil phase, li is further preferred if the emulsion is stabilized by emulsifier.
- the emulsifier is preferably selected from the group of anionic emulsifier, whereby sodium stearoyl glutamate is preferred. .
- the emulsifier are present in a total quantity ranging from 0.1 to 0.5% by weight, more preferably 0.2 to 0.4% by weight, calculated to the total weight of the emulsion.
- the anionic emulsifier are present in a total quantity ranging from 0.1 to 0.5% by weight, more preferably 0.2 to 0.4% by weight, calculated to the total weight of the emulsion.
- the foamability of the composition and the resulting foam stability can be improved. Accordingly, it is preferred if the emulsion comprises at least one polymer selected from the group of xanthan gum, succinoglycan, sclerotium gum and hydroxypropyl starch phosphate. Most preferred are xanthan gum and/or succinoglycan.
- succinoglycan is contained in the emulsion, it is preferred if the total quantity of succinoglycan is in the range from 0.2 to 1.5% by weight, more preferably 0.8 to 1.3% by weight, calculated to the total weight of the emulsion.
- xanthan gum is contained in the emulsion, it is preferred if the total quantity of xanthan gum is in the range from 0.1 to 1.2% by weight, more preferably 0.3 to 0.8% by weight, calculated to the total weight of the emulsion.
- succinoglycan and xanthan gum are contained, it is preferred if the ratio by weight of succinoglycan to xanthan gum is from 5:1 to 1 :1 and more preferably 3:1 to 1.5:1.
- the emulsion comprises ethanol in small quantities, ranging from 0.1 to 2% by weight, based on the total weight of the emulsion.
- the emulsion comprises glycerol, whereby it is preferred if the total quantity of glycerol is in the range from 1.0 to 15% by weight, more preferably 1.5 to 10.0% and most preferably 3.0 to 7.0% by weight, calculated to the total weight of the emulsion. Further it is preferred if the emulsion comprises p-anisic acid, levulinic acid and/or sodium levulinate.
- the total quantity of p-anisic acid, levulinic acid and/or sodium levulinate is in the range from 0.1 to 1% by weight, more preferably 0.2 to 0.8% by weight and most preferably 0.3 to 0.6% by weight, calculated to the total weight of the emulsion.
- the composition is characterized in that at least one UV- filter is contained.
- UV filter is understood as a substance which is listed in the IIV-A and IIV-B filter list in the Annex VI of the Regulation (EC) No 1223/2009 of the European Parliament and of the Council.
- emulsion comprises at least one organic UV-filter, which is selected from the group consisting of camphor benzalkonium methosulfate, homosalate, benzophenone-3, butyl methoxydibenzoylmethane, benzylidene camphor sulfonic acid, octocrylene, polyacrylamidomethyl benzylidene camphor, ethylhexyl methoxycinnamate, peg-25 paba, isoamyl p-methoxycinnamate, ethylhexyl triazone, drometrizole trisiloxane, diethylhexyl butamido triazone, 4-methylbenzylidene camphor, ethylhexyl salicylate, ethylhexyl dimethyl paba, methylene bis-benzotriazolyl tetramethylbutylphenol, methylene bis-benzotri
- the emulsion comprises bis-ethylhexyloxyphenol methoxyphenyl triazine, whereby the total quantity of bis-ethylhexyloxyphenol methoxyphenyl triazine is preferably in the range from 0.5 to 12% by weight, preferably 0.6 to 6% by weight, particularly preferably 0.7 to 3.5% by weight based on the total weight of emulsion.
- the emulsion comprises ethylhexyl salicylate, whereby the total quantity of ethylhexyl salicylate is preferably in the range from 0.5 to 12% by weight, preferably 2 to 9% by weight, particularly preferably 3 to 7.5% by weight based on the total weight of emulsion. It is further preferred if the emulsion comprises ethylhexyl triazone, whereby the total quantity of ethylhexyl triazone is preferably in the range from 0.1 to 5% by weight, preferably 0.2 to 3% by weight, particularly preferably 0.3 to 1.5% by weight based on the total weight of emulsion.
- the emulsion comprises butyl methoxydibenzoylmethane, whereby the total quantity of butyl methoxydibenzoylmethane is preferably in the range from 0.5 to 12% by weight, preferably 0.6 to 6% by weight, particularly preferably 0.7 to 2.5% by weight based on the total weight of emulsion.
- the total quantity of all organic UV filters is in the range from 5 to 18% by weight, more preferably 7 to 15% by weight and most preferably 8.5 to 12.5% by weight, calculated to the total weight of the emulsion.
- the emulsion of the invention is free from octocrylene. That means the content of octocrylene is preferably 0% by weight based on the total weight of the emulsion.
- Emulsifiers are understood to be all substances which are listed in the International Cosmetic Ingredient Dictionary and Handbook, Thirteenth Edition 2010, (ISBN 1-882621-47-6) under the name "emulsifying agent”.
- Surfactants are understood to be all substances which are listed in the International Cosmetic Ingredient Dictionary and Handbook, Thirteenth Edition 2010, (ISBN 1-882621-47-6) under the name "surfactant”.
- Some preferred embodiments of the invention are characterized in that the emulsion does not contain a homo- or copolymer of acrylic acid.
- Those formulations are particular environmentally friendly as they rely on plant derived ingredients to set up the rheological profile of the composition.
- the emulsions of the invention may further comprise active ingredients which can have a beneficial aspect for the human skin.
- active ingredients are Glycyrrhetinic acid, arctiin, folic acid, coenzyme Q10 (ubiquinone), alpha-glucosylrutin, carnitine, carnosine, caffeine, natural and I or synthetic isoflavonoids, glycerylglucose, creatine, creatinine, taurine, tocopherol, tocopherol acetate, vitamin C, vitamin C phosphate, vitamin C palmitate, niacinamides, vitamin A palmitate, retinol, panthenol, glycyrrhiza inflata root extract, licochalcon A, 4-butylresorcinol, N - [(2,4-dihydroxyphenyl) thiazol-2-yl] isobutyramide, honociol and magnolol (also as a component of Magnolia-
- compositions were prepared forming an emulsion from all ingredients apart from caprylyl glycol, p-anisic acid, levulinic acid and sodium levulinate, if present.
- To form the emulsion both the water and oil phase were heated and mixed at elevated temperatures.
- the emulsion was formed by homogenization using a Silverson Series L5. Caprylyl glycol, p-anisic acid, levulinic acid and sodium levulinate, if present.
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Abstract
Cosmetic composition.
Description
Protein formulation
The present invention belongs to the cosmetic field and relates to a cosmetic composition comprising proteins.
A beautiful and attractive appearance is a desire for many people. One typical sign of such an appearance is a healthy and smooth looking skin. Therefore, in order to take care of the skin, it is for many people a daily routine to apply cosmetic products such as body lotions, sunscreens or deodorant compositions.
In the search for new textures for skin care products, foam formats have attracted a lot of attention. However, to obtain such textures there are currently two routes:
The first approach involves aerosol products, in which a cosmetic composition is stored in pressurized container having a valve suitable to dispense the composition. Depending on the header located on the outer part of the valve the composition may be dispensed in form a dense foam. Looking at this approach from the environmental side, it is not ideal that the formulations has to be put into a pressurized container as this requires significant amount of energy to produce the required overpressure. Furthermore, the release of propellants such as propane and/or butane may not be in the interest of the environment.
The second approach are products, which are converted into foam in the production process by injecting a gas into a denser formula. Thereby, dense formula is understood as a highly viscose formula comprising considerable amounts of suitable waxes and polymers allowing air to remain within the formulation. However, the sensory is very dense and thick, and it is not possible to obtain light textures by this means. Furthermore, the polymers included are usually acrylic polymers. However, due to the not known degradability of the polymer in the environment it is in the interest of all if formulations do not require the presence of acrylic polymers anymore. Acrylic polymers are polymers formed by homo- or copolymerization with acrylic and/or methacrylic acid.
Due to the environmental impact of the foamed cosmetic compositions described above many consumers are happy to convert a non-foamed composition into a foamed composition
on their own at home. This is in line with the general trend to individualized cosmetics, in which the consumer creates fully formulas or modify commercial formulas to their needs. For the foam conversion it is thereby essential desirable that the foam can easily be created at home, e.g. using a conventional kitchen stirrer/mixer.
Thereby it is problematic that formulations which may be converted into foam using household devices suffer a number of disadvantages. For examples, most foamable composition do not allow to form a foam having a light texture, which can only be obtained with compositions dispensed with propellant from aerosols. Further, the foam obtained does often not have a thick, dense appearance. Furthermore, it is often observed that the foam is not stable for a prolonged amount of time, meaning that the foam does rapidly collapse after creating it. Accordingly, it is desirable to provide foamable compositions which allow to provide foam with a household stirrer, whereby the foam does not suffer the disadvantages discussed above. Further it is desirable to provide foamable composition which allow for a thick foam to be obtained using household mixer, whereby the foam is easy to spread and very light during the application on the skin. Further, it is desirable that the foamable composition is environmentally acceptable, meaning that the presence of acrylic polymers is not required. Further it is desirable if the foam created is very dense, having small air bubble size, having a creamy appearance and is capable of maintaining its structure if stored at 40°C for a prolonged amount of time, without showing a water separation.
It was surprisingly found by the applicant that the points raised above can be addressed by the present invention.
Prior art foaming compositions are disclosed in WO 2000061076 A1 and DE 102010055817 A1. However, the documents could not direct the person skilled in art to the present invention.
The present invention is a cosmetic emulsion comprising, based on the total weight of the emulsion, a) at least one protein, b) at least one pH modifier, and c) an emollient system.
All weight percentages (% by weight) given below relate, unless otherwise stated, to the total weight of the cosmetic emulsion. If ratios of certain components are disclosed in the following description, these ratios refer, unless otherwise stated, to weight ratios of the components.
Unless otherwise stated, all tests and measurements were performed under “normal conditions”. The term "normal conditions" refers to 20°C, 1013 hPa and a relative humidity of 50%.
The term “skin” refers solely to human skin.
A further object of the present invention is the use of an emulsion according to the invention to provide foam upon stirring the emulsion.
A further object of the invention is a method of providing foam by providing an emulsion according to the invention and consecutively suspending air in the emulsion, preferably by mechanically stirring.
It was surprisingly noticed that emulsion according to the invention allowed to create a foam as required, while no foam was observed using instead of proteins hydrolyzed proteins or fragmented proteins. Hydrolyzed proteins are derived from the hydrolysis of a protein into its component amino acids and peptides. Accordingly, the original protein is no more intact.
According to the invention it is preferred if the emulsion according to the invention is characterized in that it is an oil in water emulsion.
The invention is characterized in that the emulsion comprises at least one protein. It is preferred if the total content of the proteins in the formulation is ideally from 0.5% to 8.0%, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion.
It is preferred if the protein is a natural occurring protein.
The person skilled in art is aware that proteins may be subdivided depending on their structure:
Fibrous proteins are linear (long fibrous) in shape. Typical examples are a-Keratin, - Keratin and Collagen.
Globular proteins are spherical or globular in shape. Typical examples are a- lactalbumin, p-lactoglobulin, myoglobin and hemoglobin.
Further, proteins may also be classified according to their composition:
Simple proteins are composed of only amino acids, whereby the proteins may be fibrous or globular. Typical simple proteins are bovine albumin and casein.
Conjugate proteins are complex proteins, which contain one or more non-amino acid components. Typical examples are lipoproteins or glycoproteins.
According to the invention it is preferred if the at least one protein contained is characterized in that the protein is a globular protein. Following this, it is preferred if the total content of the globular protein(s) in the formulation is from 0.5% to 8.0%, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion.
According to the invention, it is also preferred if the proteins contained are characterized in that the proteins are simple proteins. Following this, it is preferred if the total content of the simple protein(s) in the formulation is from 0.5% to 8.0%, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion.
It is most preferred if the proteins according to the invention are simple, globular proteins. Accordingly, it is also most preferred if the emulsion comprises at least one simple, globular protein, whereby the total quantity of those proteins is preferably in the range from 0.5% to 8.0%, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion.
It should be noted that among the named classes of proteins as described above some proteins showed particular effective foaming properties. Particular preferred are the a- lactalbumin, p-lactoglobulin and/or casein; whereby a-lactalbumin and/or p-lactoglobulin are most preferred.
Accordingly it is preferred if a-lactalbumin, p-lactoglobulin and/or casein are contained in the emulsion according to the invention in a total quantity of from 0.5% to 8.0%, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion.
It is further preferred if a-lactalbumin and/or p-lactoglobulin are contained in the emulsion according to the invention in a total quantity of from 0.5% to 8.0%, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion.
Preferred embodiments of the invention are characterized in that the protein is chosen from the group consisting of sunflower proteins, chickpea proteins, pea proteins, lentil proteins, lupin proteins, rice protein, fava bean protein, collagen, whey protein, casein, keratin, algae derived proteins and yeast derived proteins. It is more preferred if the protein contained is whey protein and/or casein. Most preferred is whey protein.
Accordingly it is preferred if the proteins chosen from the group consisting of sunflower proteins, chickpea proteins, pea proteins, lentil proteins, lupin proteins, rice protein, fava bean protein, collagen, whey protein, casein, keratin, algae derived proteins and yeast derived proteins are contained in the emulsion according to the invention in a total quantity of from 0.5% to 8.0%, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion.
It is further preferred if the proteins whey protein and/or casein are contained in the emulsion according to the invention in a total quantity of from 0.5% to 8.0%, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion.
Further it is most preferred if whey protein is contained in the emulsion according to the invention in a total quantity of from 0.5% to 8.0%, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion. Further it is preferred if no further proteins are contained.
According to the invention it is preferred if the emulsion comprises at least one pH modifier. A pH modifier is understood as, at normal conditions, a water soluble compound, which is an acid or bases. It is particular preferred if the pH modifier is an acid and/or a salt thereof.
Preferred pH modifier used according to the invention are selected from the group of glycolic acid, lactic acid, mandelic acid, citric acid, salicylic acid, hydroxybutanoic acid, hyaluronic acid, ascorbic acid, tartaric acid, malic acid, azelaic acid, ferulic acid and salts thereof.
Particular preferred are citric acid, tartaric acid and/or salts thereof.
It is even more preferred if the pH modifier are citric acid and/or potassium acid tartrate.
It is most preferred if at least potassium acid tartrate is contained as pH modifier. Especially for the case that potassium acid tartrate is used, it was surprisingly noted that the foam had a prolonged stability and did not collapse.
According to the invention it is preferred if the total content of the pH modifier is in the range from 0.2 to 5.0% by weight, more preferably 0.5 to 3.0% by weight and most preferably 1.0 to 1.8% by weight, calculated to the total weight of the emulsion.
For the case that citric acid is contained in the emulsion of the invention as pH modifier, it is preferred if the total quantity of citric acid is in the range from 0.1 to 2.0% by weight, more preferably 0.15 to 0.8% by weight and most preferably 0.18 to 0.6% by weight, calculated to the total weight of the emulsion.
For the case that potassium acid tartrate is contained in the emulsion of the invention as pH modifier, it is preferred if the total quantity of potassium acid tartrate is in the range from 0.1 to 4.0% by weight, more preferably 0.5 to 2.5% by weight and most preferably 0.8 to 1.5% by weight, calculated to the total weight of the emulsion.
It is also preferred if the ratio between the total content of the total quantities of the protein and the total quantities of the pH modifier is in the range from 10:1 to 1:2, more preferably 8:1 to 1:1 and most preferably 3.5:1 to 2.5:1.
According to the invention the emulsion is characterized in that it comprises an emollient system. An emollient system comprises at least one emollient.
Emollients are understood to be all substances which are listed in the International Cosmetic Ingredient Dictionary and Handbook, Thirteenth Edition 2010, (ISBN 1-882621-47-6) under the name "emollient".
Preferred emollients to be contained in the emollient system are selected from the group of cosmetic butters. It is particular preferred if cupuacu butter, murumuru butter and/or butyrospermum parkii (shea) butter are contained. It is most preferred if the emollient system comprises at least butyrospermum parkii (shea) butter.
For the case that at least one cosmetic butter is contained in the emollient system it is preferred if the total quantity of the cosmetic butters is in the range from 0.5 to 20% by weight, more preferably 5% to 18% by weight and most preferred 8% to 15% by weight, calculated to the total weight of the emulsion.
For the case that cupuacu butter, murumuru butter and/or butyrospermum parkii (shea) butter are contained in the emollient system it is preferred if the total quantity of cupuacu butter, murumuru butter and/or butyrospermum parkii (shea) butter is in the range from 0.5 to 20% by weight, more preferably 5% to 18% by weight and most preferred 8% to 15% by weight, calculated to the total weight of the emulsion.
For the case that butyrospermum parkii (shea) butter is contained in the emollient system it is preferred if the total quantity of butyrospermum parkii (shea) butter is in the range from 0.5 to 20% by weight, more preferably 5% to 18% by weight and most preferred 8% to 15% by weight, calculated to the total weight of the emulsion.
According to the invention it is also preferred if the ratio of oil and wax components that are liquid under normal conditions to the oil and wax components that are solid, respectively not liquid, under normal conditions is in the range from 1 :1 to 1:1000, more preferably 1:1.5 to 1 :500 and most preferably 1 :2 to 1:25.
For the case that the emulsion comprises further an oil and/or wax component that is liquid under normal conditions it is preferred if at least one natural oil is contained. Preferred natural oils are selected from the list soya oil, cotton seed oil, sunflower oil, palm oil, palm kernel oil, linseed oil, almond oil, castor oil, vegetable oil, corn oil, olive oil, rapeseed oil, sesame oil, thistle oil, wheat germ oil, avocado oil, peach kernel oil and/or the liquid fractions of coconut oil. Most preferred is vegetable oil.
Further, it is preferred if the emulsion comprises further at least one fatty alcohol selected from the group of cetyl alcohol, stearyl alcohol and/or cetearyl alcohol. Thereby, it is preferred if the total quantity of those fatty alcohols is in the range from 0.5 to 6% by weight, more preferably 1.5 to 5.5% by weight and most preferably from 2.2 to 4.2% by weight calculated to the total weight of the emulsion.
Furthermore, preferred emulsions according to the invention are characterized in that the emulsion comprises an outer aqueous phase and an inner oil phase, li is further preferred if
the emulsion is stabilized by emulsifier. The emulsifier is preferably selected from the group of anionic emulsifier, whereby sodium stearoyl glutamate is preferred. .
According to the invention it is preferred if the emulsifier are present in a total quantity ranging from 0.1 to 0.5% by weight, more preferably 0.2 to 0.4% by weight, calculated to the total weight of the emulsion.
According to the invention it is preferred if the anionic emulsifier are present in a total quantity ranging from 0.1 to 0.5% by weight, more preferably 0.2 to 0.4% by weight, calculated to the total weight of the emulsion.
It was further surprisingly noticed that by adding specific polymers the foamability of the composition and the resulting foam stability can be improved. Accordingly, it is preferred if the emulsion comprises at least one polymer selected from the group of xanthan gum, succinoglycan, sclerotium gum and hydroxypropyl starch phosphate. Most preferred are xanthan gum and/or succinoglycan.
For the case that succinoglycan is contained in the emulsion, it is preferred if the total quantity of succinoglycan is in the range from 0.2 to 1.5% by weight, more preferably 0.8 to 1.3% by weight, calculated to the total weight of the emulsion.
For the case that xanthan gum is contained in the emulsion, it is preferred if the total quantity of xanthan gum is in the range from 0.1 to 1.2% by weight, more preferably 0.3 to 0.8% by weight, calculated to the total weight of the emulsion.
For the case that both succinoglycan and xanthan gum are contained, it is preferred if the ratio by weight of succinoglycan to xanthan gum is from 5:1 to 1 :1 and more preferably 3:1 to 1.5:1.
According to the invention it is further preferred if the emulsion comprises ethanol in small quantities, ranging from 0.1 to 2% by weight, based on the total weight of the emulsion.
Further it is preferred if the emulsion comprises glycerol, whereby it is preferred if the total quantity of glycerol is in the range from 1.0 to 15% by weight, more preferably 1.5 to 10.0% and most preferably 3.0 to 7.0% by weight, calculated to the total weight of the emulsion.
Further it is preferred if the emulsion comprises p-anisic acid, levulinic acid and/or sodium levulinate.
It is preferred if the total quantity of p-anisic acid, levulinic acid and/or sodium levulinate is in the range from 0.1 to 1% by weight, more preferably 0.2 to 0.8% by weight and most preferably 0.3 to 0.6% by weight, calculated to the total weight of the emulsion.
According to the present invention the composition is characterized in that at least one UV- filter is contained.
The term UV filter is understood as a substance which is listed in the IIV-A and IIV-B filter list in the Annex VI of the Regulation (EC) No 1223/2009 of the European Parliament and of the Council.
It is preferred if emulsion comprises at least one organic UV-filter, which is selected from the group consisting of camphor benzalkonium methosulfate, homosalate, benzophenone-3, butyl methoxydibenzoylmethane, benzylidene camphor sulfonic acid, octocrylene, polyacrylamidomethyl benzylidene camphor, ethylhexyl methoxycinnamate, peg-25 paba, isoamyl p-methoxycinnamate, ethylhexyl triazone, drometrizole trisiloxane, diethylhexyl butamido triazone, 4-methylbenzylidene camphor, ethylhexyl salicylate, ethylhexyl dimethyl paba, methylene bis-benzotriazolyl tetramethylbutylphenol, methylene bis-benzotriazolyl tetramethylbutylphenol, bis-ethylhexyloxyphenol methoxyphenyl triazine, polysilicone-15, diethylamino hydroxybenzoyl hexyl benzoate, tris-biphenyl triazine / tris-biphenyl triazine and phenylene bis-diphenyltriazine.
It is further preferred if the emulsion comprises bis-ethylhexyloxyphenol methoxyphenyl triazine, whereby the total quantity of bis-ethylhexyloxyphenol methoxyphenyl triazine is preferably in the range from 0.5 to 12% by weight, preferably 0.6 to 6% by weight, particularly preferably 0.7 to 3.5% by weight based on the total weight of emulsion.
It is further preferred if the emulsion comprises ethylhexyl salicylate, whereby the total quantity of ethylhexyl salicylate is preferably in the range from 0.5 to 12% by weight, preferably 2 to 9% by weight, particularly preferably 3 to 7.5% by weight based on the total weight of emulsion.
It is further preferred if the emulsion comprises ethylhexyl triazone, whereby the total quantity of ethylhexyl triazone is preferably in the range from 0.1 to 5% by weight, preferably 0.2 to 3% by weight, particularly preferably 0.3 to 1.5% by weight based on the total weight of emulsion.
It is further preferred if the emulsion comprises butyl methoxydibenzoylmethane, whereby the total quantity of butyl methoxydibenzoylmethane is preferably in the range from 0.5 to 12% by weight, preferably 0.6 to 6% by weight, particularly preferably 0.7 to 2.5% by weight based on the total weight of emulsion.
It is further preferred if the total quantity of all organic UV filters is in the range from 5 to 18% by weight, more preferably 7 to 15% by weight and most preferably 8.5 to 12.5% by weight, calculated to the total weight of the emulsion.
Nevertheless, it is preferred if the emulsion of the invention is free from octocrylene. That means the content of octocrylene is preferably 0% by weight based on the total weight of the emulsion.
Emulsifiers are understood to be all substances which are listed in the International Cosmetic Ingredient Dictionary and Handbook, Thirteenth Edition 2010, (ISBN 1-882621-47-6) under the name "emulsifying agent". Surfactants are understood to be all substances which are listed in the International Cosmetic Ingredient Dictionary and Handbook, Thirteenth Edition 2010, (ISBN 1-882621-47-6) under the name "surfactant".
Some preferred embodiments of the invention are characterized in that the emulsion does not contain a homo- or copolymer of acrylic acid. Those formulations are particular environmentally friendly as they rely on plant derived ingredients to set up the rheological profile of the composition.
The emulsions of the invention may further comprise active ingredients which can have a beneficial aspect for the human skin. Preferred examples of such active ingredients are Glycyrrhetinic acid, arctiin, folic acid, coenzyme Q10 (ubiquinone), alpha-glucosylrutin, carnitine, carnosine, caffeine, natural and I or synthetic isoflavonoids, glycerylglucose, creatine, creatinine, taurine, tocopherol, tocopherol acetate, vitamin C, vitamin C phosphate, vitamin C palmitate, niacinamides, vitamin A palmitate, retinol, panthenol, glycyrrhiza inflata root extract, licochalcon A, 4-butylresorcinol, N - [(2,4-dihydroxyphenyl) thiazol-2-yl]
isobutyramide, honociol and magnolol (also as a component of Magnolia- Extracts), hyaluronic acid and / or silymarin.
Examples:
The following examples should illustrate the compositions of this invention, without intending to limit the invention to these examples. The numerical values in the examples are percentages by weight, based on the total weight of the preparations.
The following preparations were prepared and compared.
Comprises at least 66.3% a-lactalbumin, 25.5% p-lactoglobulin and 8.2% bovine albumin.
The compositions were prepared forming an emulsion from all ingredients apart from caprylyl glycol, p-anisic acid, levulinic acid and sodium levulinate, if present. Caprylyl glycol, p-anisic acid, levulinic acid and sodium levulinate, if present, were added after the emulsion was formed. To form the emulsion both the water and oil phase were heated and mixed at elevated temperatures. The emulsion was formed by homogenization using a Silverson Series L5. Caprylyl glycol, p-anisic acid, levulinic acid and sodium levulinate, if present. Caprylyl glycol, p-anisic acid, levulinic acid and sodium levulinate, if present, were added after homogenization. After cooling a foam formulation was created using a Kitchenaid blender Artisan 4.8 I. The formulations were mixed until the foam created did not obiously change its properties (bubble size, viscosity, thickness, creaminess) anymore.
For example the formed foam was stored at 40°C to evaluate at which point the structure collapses. The results are summarized in the following table:
Claims
1. Cosmetic emulsion comprising, based on the total weight of the emulsion, a) at least one protein, b) at least one pH modifier, and c) an emollient system.
2. Emulsion according to claim 1 characterized in that the content of the proteins in the formulation is from 0.5% to 8.0% by weight, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion.
3. Emulsion according to any proceeding claim characterized in that the emulsion comprises at least one globular protein, whereby it is preferred, if the total content of the globular protein(s) in the formulation is from 0.5% to 8.0% by weight, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion.
4. Emulsion according to any proceeding claim characterized in that the emulsion comprises at least one simple protein, whereby it is preferred if the total content of the simple protein(s) in the formulation is from 0.5% to 8.0% by weight, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion.
5. Emulsion according to any proceeding claim characterized in that the emulsion comprises simple, globular proteins, whereby the total quantity of those proteins is preferably in the range from 0.5% to 8.0% by weight, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion.
6. Emulsion according to any proceeding claim characterized in that the emulsion comprises a-lactalbumin, p-lactoglobulin and/or casein; whereby a-lactalbumin and/or P-lactoglobulin are most preferred.
7. Emulsion according to claim 6 characterized in that a-lactalbumin and/or p- lactoglobulin are contained in the emulsion in a total quantity of from 0.5% to 8.0% by weight, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion.
8. Emulsion according to claim 1 characterized in that that the protein is chosen from the group consisting of sunflower proteins, chickpea proteins, pea proteins, lentil proteins, lupin proteins, rice protein, fava bean protein, collagen, whey protein, casein, keratin, algae derived proteins and yeast derived proteins.
9. Emulsion according to claim 8 characterized the proteins chosen from the group consisting of sunflower proteins, chickpea proteins, pea proteins, lentil proteins, lupin
proteins, rice protein, fava bean protein, collagen, whey protein, casein, keratin, algae derived proteins and yeast derived proteins are contained in the emulsion according to the invention in a total quantity of from 0.5% to 8.0% by weight, more preferably from 1.0% to 6.0% by weight and most preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion. Emulsion according to claim 8 characterized in that whey protein is contained in the emulsion according to the invention in a total quantity of from 0.5% to 8.0% by weight, preferably from 1.0% to 6.0% by weight and more preferably from 2.0 to 3.8% by weight, calculated to the total weight of the emulsion, whereby it is preferred if no further protein is contained. Emulsion according to any proceeding claim characterized in that pH modifier is an acid or a salt thereof. Emulsion according to any proceeding claim characterized in that pH modifier is selected from the group of glycolic acid, lactic acid, mandelic acid, citric acid, salicylic acid, hydroxybutanoic acid, hyaluronic acid, ascorbic acid, tartaric acid, malic acid, azelaic acid, ferulic acid and salts thereof. Emulsion according to any proceeding claim characterized in that pH modifier are citric acid and/or potassium acid tartrate. Emulsion according to any proceeding claim characterized in that the total content of the pH modifier is in the range from 0.2 to 5.0% by weight, more preferably 0.5 to 3.0% by weight and most preferably 1.0 to 1.8% by weight, calculated to the total weight of the emulsion. Emulsion according to any proceeding claim characterized in that citric acid is contained in the emulsion as pH modifier, whereby it is preferred if the total quantity of citric acid is in the range from 0.1 to 2.0% by weight, more preferably 0.15 to 0.8% by weight and most preferably 0.18 to 0.6% by weight, calculated to the total weight of the emulsion. Emulsion according to any proceeding claim characterized in that potassium acid tartrate is contained in the emulsion as pH modifier, whereby it is preferred if the total quantity of potassium acid tartrate is in the range from 0.1 to 4.0% by weight, more preferably 0.5 to 2.5% by weight and most preferably 0.8 to 1.5% by weight, calculated to the total weight of the emulsion. Emulsion according to any proceeding claim characterized in that the ratio between the total content of the total quantities of the protein and the total quantities of the pH modifier is in the range from 10:1 to 1:2, more preferably 8:1 to 1:1 and most preferably 3.5:1 to 2.5:1.
Emulsion according to any proceeding claim characterized in that the emollient system comprises cosmetic butters, in particular cupuacu butter, murumuru butter and/or butyrospermum parkii (shea) butter. Emulsion according to any proceeding claim characterized in that the total quantity of the cosmetic butters is in the range from 0.5 to 20% by weight, more preferably 5% to 18% by weight and most preferred 8% to 15% by weight, calculated to the total weight of the emulsion. Emulsion according to any proceeding claim characterized in that the emulsion comprises at least one polymer selected from the group of xanthan gum, succinoglycan, sclerotium gum and hydroxypropyl starch phosphate. Most preferred are xanthan gum and/or succinoglycan. Method of providing foam by providing an emulsion according to any of the claims 1 to 20 in a first step and in a second step suspending air in the emulsion, preferably by mechanically stirring, to provide foam.
16
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2021/051011 WO2022156877A1 (en) | 2021-01-19 | 2021-01-19 | Protein formulation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2021/051011 WO2022156877A1 (en) | 2021-01-19 | 2021-01-19 | Protein formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2022156877A1 true WO2022156877A1 (en) | 2022-07-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| PCT/EP2021/051011 WO2022156877A1 (en) | 2021-01-19 | 2021-01-19 | Protein formulation |
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| WO (1) | WO2022156877A1 (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000061076A1 (en) | 1999-04-14 | 2000-10-19 | Unilever Plc | Foaming cosmetic products |
| DE102010055817A1 (en) | 2010-12-23 | 2012-06-28 | Henkel Ag & Co. Kgaa | Foaming agent-containing foamable cosmetic composition for skin and body care |
| US20120238489A1 (en) * | 2010-03-18 | 2012-09-20 | Juan Carlos Arboleya Payo | Method for improving functional properties by means of pulsed light, samples with improved functional properties and uses thereof |
| WO2014018929A2 (en) * | 2012-07-26 | 2014-01-30 | Solae, Llc | Foaming agent for use in personal care products and industrial products |
| KR101974405B1 (en) * | 2018-11-30 | 2019-05-02 | 이호 | Cosmetic composition comprising hydrolyzate of colostrum whey protein for skin regeneration |
-
2021
- 2021-01-19 WO PCT/EP2021/051011 patent/WO2022156877A1/en active Application Filing
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000061076A1 (en) | 1999-04-14 | 2000-10-19 | Unilever Plc | Foaming cosmetic products |
| US20120238489A1 (en) * | 2010-03-18 | 2012-09-20 | Juan Carlos Arboleya Payo | Method for improving functional properties by means of pulsed light, samples with improved functional properties and uses thereof |
| DE102010055817A1 (en) | 2010-12-23 | 2012-06-28 | Henkel Ag & Co. Kgaa | Foaming agent-containing foamable cosmetic composition for skin and body care |
| WO2014018929A2 (en) * | 2012-07-26 | 2014-01-30 | Solae, Llc | Foaming agent for use in personal care products and industrial products |
| KR101974405B1 (en) * | 2018-11-30 | 2019-05-02 | 이호 | Cosmetic composition comprising hydrolyzate of colostrum whey protein for skin regeneration |
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| Title |
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| "International Cosmetic Ingredient Dictionary and Handbook", 2010 |
| BEAUTYGLIMPSE.COM: "7 Ultra-Moisturizing Mayonnaise Facial Masks to Look Beautiful Inside Out", 3 June 2020 (2020-06-03), XP055852903, Retrieved from the Internet <URL:https://www.beautyglimpse.com/how-to-treat-your-skin-with-mayonnaise-facial-masks/> [retrieved on 20211019] * |
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