WO2022156206A1

WO2022156206A1 - Active drug dissolution precipitate obtaining device

Info

Publication number: WO2022156206A1
Application number: PCT/CN2021/113423
Authority: WO
Inventors: 刘合义; 陈英
Original assignee: 竹简云(天津)生物科技有限公司
Priority date: 2021-01-19
Filing date: 2021-08-19
Publication date: 2022-07-28
Also published as: CN112892251A; CN112892251B

Abstract

The present invention relates to the technical field of drug analysis and detection, and in particular, to an active drug dissolution precipitate obtaining device. A stirring device comprises a fixing base, an adaptation ball, a power end, and a stirring rod; the stirring rod comprises an inner tube and an outer tube; the top end of the outer tube penetrates through the adaptation ball, such that the outer tube and the adaptation ball synchronously rotate with respect to the rotation of the fixing base; the bottom end of the inner tube extends into a dissolution vessel; the top end of the outer tube is connected to the power end by means of a ball hinge, and is driven by the power end to move in a circular track in the horizontal plane; a rotation center of the top end of the outer tube and a rotation center of the adaptation ball are located on the same longitudinal axis; the end portion of the outer tube is provided with a cavity; a spring is provided in the cavity; and the inner tube extends into the cavity to press the spring. According to the present invention, the stirring process is more uniform and stable; when a precipitate is measured at different stirring times, relatively consistent stirring behaviors can be obtained, so that the relation between the stirring time and the precipitation amount is established under a relatively unified standard, and the measurement accuracy is ensured.

Description

An active drug-dissolved sediment acquisition device

technical field

The invention relates to the technical field of drug analysis and detection, in particular to an active drug-dissolved sediment acquisition device.

Background technique

The solubility of food and drugs is an important indicator related to the effectiveness of drugs. In the current testing process, most of the external drugs to be tested are poured into the cavity through the stirring port of the dissolving cup, and the external stirring rods are used to manually adjust the chemical in the cavity. The medicine can be stirred to dissolve.

However, during manual stirring, the stirring action of the stirring rod must vary with time, and it is extremely difficult to control the degree of stirring. Difficult to control, making it difficult to guarantee the accuracy of the measurement.

In view of the above-mentioned existing defects, the inventor of the present invention, based on the rich practical experience and professional knowledge engaged in the design and manufacture of such products for many years, and with the application of academic theory, actively conducts research and innovation, in order to create an active drug-dissolved sediment acquisition device, which enables It is more practical.

SUMMARY OF THE INVENTION

The present invention provides an active drug-dissolving sediment obtaining device, so as to effectively solve the problems in the background technology.

In order to achieve the above object, the technical scheme adopted in the present invention is:

An active drug dissolution sediment acquisition device, comprising: a dissolution container, a stirring device and a workbench;

The stirring device includes a fixed seat, a transfer ball, a power end and a stirring rod; the stirring rod includes an inner tube and an outer tube, the outer tube is arranged on the top of the inner tube, and the top of the outer tube is connected with the rotating rod. The ball is fixedly connected, so that the outer tube and the transfer ball rotate synchronously with respect to the rotation of the fixed seat, and the bottom end of the inner tube extends into the dissolving container for liquid stirring; the top end of the outer tube It is connected with the power end through a ball hinge, and is driven by the power end to move in a circular orbit in the horizontal plane. The rotation center of the top end of the outer tube and the rotation center of the transfer ball are on the same longitudinal axis. ;

The end of the outer tube is provided with a cavity, the cavity is provided with a spring, the inner tube extends into the cavity and squeezes the spring, and the inner tube is fitted with the dissolving container The end of the spherical structure.

Further, the dissolving container includes a bowl body, a filter screen and a shielding cover from outside to inside; the inner and outer surfaces of the bowl body are concentric hemispherical surfaces, and the filter screen and the inner surface of the bowl body are fitted at least at the bottom And the two can be set separately; the shielding cover is rotatably connected with the bowl body, has an inner surface of a hemispherical surface concentric with the inner surface of the bowl, and at least has a first part that holds liquid and shields the filter screen. A working position, and a second working position where the liquid is poured into the bowl body and the open end of the bowl body is shielded.

Further, the power end includes a guide rod, a slider, a first connecting rod and a second connecting rod;

The guide rod is fixedly arranged, and the slider slides along the guide rod, wherein one end of the first link and the second link are hinged, and the other end of the first link is hinged with the guide rod, The other end of the second link is hinged with the slider, the length of the second link is greater than the length of the first link, and the ball hinge is connected to the first link and the second link hinged position connection.

Further, the fixing base includes two clamping blocks arranged at a horizontally symmetrical interval, and the two clamping blocks are respectively attached to the transfer ball through a part of the spherical surface.

Further, the adapter ball is provided with a through hole for the outer tube to pass through, and the side wall of the through hole is provided with a through threaded hole, and an extrusion bolt is arranged in the threaded hole. The outer tube is squeezed and fixed.

Further, the filter screen includes a mesh body and a frame, the mesh body is fixed by the frame, the frame is attached to the inner wall of the bowl, and the inner wall of the bowl is partially provided with a stopper, It is used to limit the height of the frame, the frame is indented inward relative to the edge of the bowl body, and the bowl body is rotatably connected to the shielding cover through a portion higher than the frame.

Further, the edge of the frame is provided with a protruding holding portion, and the edge of the bowl body is provided with a notch for the holding portion to be drawn out.

Further, the edge of the bowl body is provided with a sealing retaining ring, and the sealing retaining ring is arranged in a fit with the shielding cover.

Further, the sealing retaining ring is attached to the frame.

Through the technical scheme of the present invention, the following technical effects can be achieved:

In the present invention, the setting of the transfer ball enables the stirring rod to obtain a stable rotation center, and during the rotation around the rotation center, a uniform circular stirring track is formed at the bottom of the stirring rod, thereby making the entire stirring process more uniform and stable , when it is necessary to measure the sediment under different stirring times, a relatively consistent stirring behavior can be obtained, so that the relationship between the stirring time and the amount of sediment can be established under a relatively uniform standard to ensure the accuracy of the measurement.

Description of drawings

In order to explain the embodiments of the present invention or the technical solutions in the prior art more clearly, the following briefly introduces the accompanying drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description are only These are some embodiments described in the present invention. For those of ordinary skill in the art, other drawings can also be obtained based on these drawings without any creative effort.

1 is a schematic diagram of the connection between a stirring device and a workbench in the active drug-dissolving sediment obtaining device of the present invention;

Fig. 2 is the rotation mode schematic diagram of stirring rod;

Fig. 3 is the partial enlarged view of A place in Fig. 1;

Fig. 4 is the structural representation of dissolving container;

Fig. 5 is the connection schematic diagram of inner pipe and outer pipe;

6 is a partial cross-sectional view of a stirring rod;

7 is a cross-sectional view of a dissolving vessel;

Fig. 8 is a partial enlarged view at A in Fig. 7 (the shield is at the first working position);

Fig. 9 is the schematic diagram of the shielding cover in the second working position in Fig. 7;

Figure 10 is a schematic diagram of the structure of the power end;

Fig. 11 is a partial enlarged view at B in Fig. 1;

Figure 12 is a partial cross-sectional view of the filter screen;

Figure 13 is a partial enlarged view at C in Figure 4;

Reference numerals: 1. Dissolving container; 11. Bowl body; 12. Filter screen; 121. Frame; 122. Holding part; 13. Cover; 14. Sealing retaining ring; 22, transfer ball; 23, power end; 231, guide rod; 232, slider; 233, first connecting rod; 234, second connecting rod; 24, stirring rod; 241, inner tube; 242, outer tube; 243, spring; 244, ball hinge; 245, squeeze bolt; 3, table.

Detailed ways

The present invention will be further described below in conjunction with the accompanying drawings. The following examples are only used to illustrate the technical solutions of the present invention more clearly, and cannot be used to limit the protection scope of the present invention.

In the description of the present invention, it should be noted that "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. The indicated orientation or positional relationship is based on the orientation or positional relationship shown in the accompanying drawings, which is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the indicated device or element must have a specific orientation or a specific orientation. construction and operation, and therefore should not be construed as limiting the invention.

In the description of the present invention, it should be noted that, unless otherwise expressly specified and limited, the terms "installed", "connected" and "connected" should be understood in a broad sense, for example, it may be a fixed connection or a detachable connection , or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or an indirect connection through an intermediate medium, or the internal communication between the two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood in specific situations. This embodiment is written in a progressive manner.

As shown in Figures 1-7, an active drug dissolution sediment acquisition device includes: a dissolution container 1, a stirring device 2 and a workbench 3; the stirring device 2 includes a fixed seat 21, a transfer ball 22, a power end 23 and The stirring rod 24; the stirring rod 24 includes an inner pipe 241 and an outer pipe 242, the outer pipe 242 is arranged on the top of the inner pipe 241, and the top of the outer pipe 242 is fixedly connected with the adapter ball 22, so that the outer pipe 242 and the adapter ball 22 are fixed relative to each other The base 21 rotates and rotates synchronously, the bottom end of the inner tube 241 extends into the dissolving container 1 for liquid stirring; the top end of the outer tube 242 is connected with the power end 23 through the spherical hinge 244, and is driven by the power end 23 to form a circle in the horizontal plane The rotation center of the top of the outer tube 242 and the rotation center of the transfer ball 22 are on the same longitudinal axis; the end of the outer tube 242 is provided with a cavity, a spring 243 is arranged in the cavity, and the inner tube 241 extends into the cavity , and the spring 243 is squeezed, and the end part of the inner tube 241 that is attached to the dissolution container 1 has a spherical structure.

In the present invention, the setting of the transfer ball 22 enables the stirring rod 24 to obtain a stable rotation center. During the rotation around the rotation center, a uniform circular stirring trajectory is formed at the bottom of the stirring rod 24, thereby making the entire stirring process more efficient. Uniform and stable, when it is necessary to measure the sediment under different stirring times, a relatively consistent stirring behavior can be obtained, so that the relationship between the stirring time and the amount of sediment can be established under a relatively uniform standard to ensure the accuracy of the measurement . When setting, the center of the stirring ball can be set up and down correspondingly with the center of the dissolving container 1; wherein, the power end 23 is connected with the outer tube 242, the outer tube 242 has a strong structure and can ensure stable rotation, and the inner tube 241 is connected to the outer tube 242. The tube 242 is elastically stretched and can be effectively attached to the bottom of the dissolution container 1, thereby ensuring the rolling of solid particles, and the liquid in the cavity can flow out by gravity without causing liquid residue.

As a preferred embodiment of the above embodiment, as shown in FIGS. 7 to 9 , the dissolving container 1 includes a bowl body 11 , a filter screen 12 and a shielding cover 13 from outside to inside; the inner and outer surfaces of the bowl body 11 are concentric hemispherical surfaces, and the filter screen 12 At least the bottom of the inner surface of the bowl body 11 is attached and the two can be separated; the shielding cover 13 is rotatably connected to the bowl body 11, has a hemispherical inner surface concentric with the inner surface of the bowl body 11, and has at least a liquid-holding and A first working position for shielding the filter screen 12 , and a second working position for pouring the liquid into the bowl body 11 and shielding the open end of the bowl body 11 .

During the stirring process, as shown in FIG. 8 , the shielding cover 13 is in the first working position to avoid damage to the filter screen 12 caused by the stirring device 2 , and it is arranged to fit with the stirring device 2 ; when the stirring is completed, as shown in FIG. 9 , turn it to the second working position, the liquid contained therein flows into the bowl body 11, and during the rotation of the shielding cover 13, the above-mentioned inflow action must be realized through the filter screen 12, after all the liquid transfer is completed, the shielding cover 13 In the second working position, the liquid is sealed and protected to avoid the influence of the external environment; after static, when there is an undissolved part, it will remain on the filter screen 12, and the filter screen 12 is removed and weighed. In this way, the amount of undissolved residue can be determined.

In the present invention, through the control of the stirring trajectory, the stable support of the bowl 11 and the multi-level arrangement, the uniformity of the stirring process can be improved, and the stirred liquid is directly poured into the filter screen 12 at the bottom through the shielding cover 13 for filtering. , the liquid remaining on the inner wall of the shielding cover 13 can also have the time to enter the filter screen 12 during the static process, which is more accurate than pouring into the filter structure after the stirring is completed, and the liquid is still on the filter screen 12. Then, slowly remove the filter screen 12, which can ensure that the undissolved drugs can be filtered more effectively. Compared with the impact dumping method, the possibility of solid particles passing through the filter screen 12 is reduced, thereby effectively guaranteeing detection accuracy.

As a preferred example of the above embodiment, the power end 23 includes a guide rod 231, a slider 232, a first link 233 and a second link 234; the guide rod 231 is fixedly arranged, and the slider 232 slides along the guide rod 231, wherein the first One end of the link 233 and the second link 234 are hinged, the other end of the first link 233 is hinged with the guide rod 231, the other end of the second link 234 is hinged with the slider 232, and the length of the second link 234 is greater than that of the first link 234. The length of the connecting rod 233, the ball joint 244 is connected with the hinge position of the first connecting rod 233 and the second connecting rod 234.

As shown in FIGS. 10 and 11 , during the working process, the movement of the slider 232 relative to the guide rod 231 enables the second link 234 to drive the first link 233 through one end of the first link 233 during the movement and rotation process. A link 233 rotates about the set point. Therefore, during the stirring process, only by manually applying force to the first link 233 or the slider 232, the position of the ball hinge 244 connected to the hinge position of the first link 233 and the second link 234 can be guaranteed to be obtained. The stable rotation track ensures the uniformity of the stirring action. During the stirring process, relative to the control of the rotational motion, the artificially active action is limited to the linear motion of the slider 232, or the movement of the second link 234 under the restriction of the slider 232 and the first link 233, and more It is easy to obtain stable control and reduce the difficulty of operation.

As a preferable example of the above-mentioned embodiment, the fixing base 21 includes two clamping blocks arranged horizontally symmetrically at intervals, and the two clamping blocks are respectively attached to the transfer ball 22 through a partial spherical surface. Among them, the distance between the two clamping blocks is a set value, and the two can be connected through a transition block or directly, so as to ensure the convenience of installation.

The adapter ball 22 is provided with a through hole for the outer tube 242 to pass through, and the side wall of the through hole is provided with a through threaded hole, and an extrusion bolt 245 is arranged in the threaded hole to extrude and fix the outer tube 242 . As shown in FIG. 3 , by controlling the extrusion degree of the extrusion bolt 245 , the height of the outer tube 242 can be quickly adjusted.

As a preference of the above-mentioned embodiment, the filter screen 12 includes a mesh body and a frame 121, the mesh body is fixed by the frame 121, the frame 121 is attached to the inner wall of the bowl body 11, and the inner wall of the bowl body 11 is partially provided with a stopper for The height of the frame 121 is limited, the frame 121 is retracted inward relative to the edge of the bowl body 11 , and the bowl body 11 is rotatably connected to the shielding cover 13 through a portion higher than the frame 121 . The edge of the frame 121 is provided with a protruding holding portion 122 , and the edge of the bowl body 11 is provided with a notch for the holding portion 122 to be drawn out.

Referring to FIGS. 12 and 13 , during the stirring process, the mesh body is protected by the shielding cover 13 to avoid damage to the stirring device 2 , and by changing the position of the shielding cover 13 , the frame 121 can easily drive the mesh body into and out of the bowl. 11 , the cleaning and maintenance of the entire dissolving container 1 is relatively convenient, and the rotation of the shielding cover 13 can realize the pouring of the liquid, so as to achieve the purpose of filtering through the filter screen 12 .

As a preferable example of the above-mentioned embodiment, the edge of the bowl body 11 is provided with a sealing retaining ring 14 , and the sealing retaining ring 14 is arranged to fit with the shielding cover 13 . Through the arrangement of the sealing retaining ring 14, the gap between the bowl body 11 and the shielding cover 13 is effectively sealed, and contamination during the stationary process is especially avoided. Preferably, the sealing ring 14 is detachable for cleaning. Among them, it is preferable that the sealing ring 14 is attached to the frame 121 so as to ensure the stability of the position of the frame 121 . As a preference of the above-mentioned embodiment, the sealing ring 14 is attached to the frame 121 , so as to ensure the stability of the position of the frame 121 .

The foregoing has shown and described the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited by the above-mentioned embodiments, and the descriptions in the above-mentioned embodiments and the description are only to illustrate the principle of the present invention. Without departing from the spirit and scope of the present invention, the present invention will have Various changes and modifications fall within the scope of the claimed invention. The claimed scope of the present invention is defined by the appended claims and their equivalents.

Claims

An active drug dissolution sediment acquisition device, characterized in that it comprises: a dissolution container (1), a stirring device (2) and a workbench (3);

The stirring device (2) comprises a fixed seat (21), an adapter ball (22), a power end (23) and a stirring rod (24); the stirring rod (24) comprises an inner tube (241) and an outer tube ( 242), the outer tube (242) is arranged on the top of the inner tube (241), and the top of the outer tube (242) is fixedly connected with the adapter ball (22), so that the outer tube (242) is connected to the The transfer ball (22) rotates synchronously with respect to the rotation of the fixing seat (21), and the bottom end of the inner tube (241) extends into the dissolving container (1) for liquid stirring; the outer tube The top end (242) is connected with the power end (23) through a spherical hinge (244), and is driven by the power end (23) to move in a circular orbit in the horizontal plane. The top end of the outer tube (242) The rotation center is on the same longitudinal axis as the rotation center of the transfer ball (22);

A cavity is arranged at the end of the outer tube (242), a spring (243) is arranged in the cavity, and the inner tube (241) extends into the cavity and squeezes the spring (243). , the end part of the inner tube (241) and the dissolving container (1) that is attached is a spherical structure.
The active drug-dissolving sediment obtaining device according to claim 1, characterized in that, the dissolving container (1) comprises a bowl (11), a filter screen (12) and a shield (13) from outside to inside ; The inner and outer surfaces of the bowl body (11) are concentric hemispherical surfaces, and the filter screen (12) and the inner surface of the bowl body (11) are fitted at least at the bottom and the two can be set separately; the shielding cover ( 13) It is rotatably connected to the bowl body (11), has an inner surface of a hemispherical surface concentric with the inner surface of the bowl body (11), and at least has an inner surface that holds liquid and shields the filter screen (12). A first working position, and a second working position where the liquid is poured into the bowl body (11) and the open end of the bowl body (11) is shielded.
The active drug-dissolving sediment obtaining device according to claim 2, wherein the power end (23) comprises a guide rod (231), a slider (232), a first connecting rod (233) and a second connecting rod (233) connecting rod (234);

The guide rod (231) is fixedly arranged, the slider (232) slides along the guide rod (231), wherein one end of the first link (233) and the second link (234) are hinged, so The other end of the first link (233) is hinged with the guide rod (231), the other end of the second link (234) is hinged with the slider (232), and the second link ( The length of the first link (234) is greater than the length of the first link (233), and the ball joint (244) is connected with the hinge position of the first link (233) and the second link (234).
The active drug-dissolving sediment obtaining device according to claim 1, characterized in that, the fixing base (21) comprises two clamping blocks arranged at a horizontally symmetrical interval, and the two clamping blocks are connected to the rotating block respectively through a part of a spherical surface. The catch (22) fits.
The active drug-dissolving sediment obtaining device according to claim 1 or 4, characterized in that, the adapter ball (22) is provided with a through hole through which the outer tube (242) passes, and the through hole is provided on the adapter ball (22). A through threaded hole is arranged on the side wall of the hole, and an extrusion bolt (245) is arranged in the threaded hole to extrude and fix the outer tube (242).
The active drug-dissolving sediment obtaining device according to claim 2, wherein the filter screen (12) comprises a mesh body and a frame (121), and the mesh body is fixed by the frame (121), The frame (121) is attached to the inner wall of the bowl body (11), and a stopper is partially provided on the inner wall of the bowl body (11) to limit the height of the frame (121), so The frame (121) is retracted inward relative to the edge of the bowl body (11), and the bowl body (11) is rotatably connected to the shielding cover (13) through a portion higher than the frame (121).
The active drug-dissolving sediment obtaining device according to claim 6, characterized in that, the edge of the frame (121) is provided with a protruding grip portion (122), and the edge of the bowl (11) is provided with a protruding grip portion (122). A notch for the holding part (122) to be drawn out.
The active drug-dissolving sediment obtaining device according to claim 7, characterized in that, a sealing ring (14) is provided on the edge of the bowl body (11), and the sealing ring (14) is connected to the shielding ring (14). The cover (13) is fitted to fit.
The active drug-dissolving sediment obtaining device according to claim 8, characterized in that, the sealing retaining ring (14) is fitted with the frame (121).