CN112858085B - Food drug solubility detection and analysis device - Google Patents
Food drug solubility detection and analysis device Download PDFInfo
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- CN112858085B CN112858085B CN202110069654.XA CN202110069654A CN112858085B CN 112858085 B CN112858085 B CN 112858085B CN 202110069654 A CN202110069654 A CN 202110069654A CN 112858085 B CN112858085 B CN 112858085B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N5/00—Analysing materials by weighing, e.g. weighing small particles separated from a gas or liquid
- G01N5/04—Analysing materials by weighing, e.g. weighing small particles separated from a gas or liquid by removing a component, e.g. by evaporation, and weighing the remainder
Abstract
The invention relates to the technical field of drug analysis and detection, in particular to a food drug solubility detection and analysis device, wherein a dissolving container comprises a bowl body, a filter screen and a shielding cover; the inner surface and the outer surface of the bowl body are concentric hemispheres; the shielding cover is rotatably connected with the bowl body and at least comprises a first working position for shielding the filter screen and a second working position for shielding the open end of the bowl body; the worktable comprises a rotating device, a bowl body supporting structure and a fixed seat; the rotating device comprises a power end and a rotating block, and the rotating block is connected with the bowl body through a spherical hinge; the bowl body supporting structure is provided with a plurality of balls which are horizontally and annularly attached and distributed, and each ball rotates around the center of the ball and is attached to the outer surface of the bowl body. According to the invention, through the control of the stirring track, the stable support of the bowl body and the multi-level arrangement, the uniformity of the stirring process can be improved, and the stirred liquid is directly poured into the filter screen at the bottom through the shielding cover for filtering, so that the detection accuracy is effectively ensured.
Description
Technical Field
The invention relates to the technical field of drug analysis and detection, in particular to a device for detecting and analyzing the solubility of a food drug.
Background
Food medicine solubility is an important index that concerns medicine validity, and at present testing process, mostly at first wait to examine the medicine with the external world and pour into the cavity through dissolving the stirring mouth of cup inside, the manual work stirs the medicine in the cavity through external stirring rod, makes it dissolve can.
However, during manual stirring, the stirring action of the stirring rod inevitably has difference along with the change of time, so that the problem of incomplete dissolution is easily caused, and meanwhile, when the solubility needs to be evaluated, the difficulty in obtaining and measuring undissolved precipitates is higher.
In view of the above-mentioned existing defects, the present inventors have conducted extensive practical experience and professional knowledge for many years in designing and manufacturing such products, and have conducted active research and innovation in cooperation with the application of the theory, in order to create a device for detecting and analyzing the solubility of food and drug, so as to make it more practical.
Disclosure of Invention
The invention provides a device for detecting and analyzing the solubility of food and drugs, thereby effectively solving the problems in the background technology.
In order to achieve the purpose, the invention adopts the technical scheme that:
a food drug solubility detection assay device comprising: a dissolving container, a stirring device and a workbench;
the dissolving container comprises a bowl body, a filter screen and a shielding cover from outside to inside; the inner surface and the outer surface of the bowl body are concentric hemispheres, and the filter screen is attached to at least the bottom of the inner surface of the bowl body and can be separated from the inner surface of the bowl body; the shielding cover is rotatably connected with the bowl body, is provided with a hemispherical inner surface concentric with the inner surface of the bowl body, and at least comprises a first working position for containing liquid and shielding the filter screen and a second working position for pouring the liquid into the bowl body and shielding the open end of the bowl body;
the working table comprises a rotating device, a bowl body supporting structure and a fixed seat; the rotating device comprises a power end and a rotating block which is driven by the power end to move in a circular track in a horizontal plane, and the rotating block is connected with the position, deviated from the bottommost part, of the outer surface of the bowl body through a spherical hinge; the bowl body supporting structure is provided with a plurality of balls which are horizontally and annularly attached and distributed, and each ball rotates around the center of the ball and is attached to the outer surface of the bowl body; the fixing seat fixes the stirring device, and the height of the stirring device is adjustable.
Further, the power end includes: the guide rod, the sliding block, the first connecting rod and the second connecting rod;
the guide bar is fixedly arranged, the sliding block slides along the guide bar, wherein one end of the first connecting rod is hinged to one end of the second connecting rod, the other end of the first connecting rod is hinged to the guide bar, the other end of the second connecting rod is hinged to the sliding block, the length of the second connecting rod is larger than that of the first connecting rod, and the rotating block is connected with the hinged position of the first connecting rod and the hinged position of the second connecting rod.
Further, the filter screen includes dictyosome and frame, the dictyosome passes through the frame is fixed, the frame with the laminating of the internal wall of bowl, just the part is provided with the dog on the inner wall of the bowl body, and is used for right the height of frame is restricted, the frame for the internal indent in bowl edge, the bowl body is through being higher than the part of frame with the shield cover rotates and is connected.
Furthermore, the edge of the frame is provided with a protruding holding part, and the edge of the bowl body is provided with a notch for leading out the holding part.
Further, the edge of the bowl body is provided with a sealing retainer ring, and the sealing retainer ring is attached to the shielding cover.
Further, the sealing retainer ring is attached to the frame.
Further, bowl body bearing structure includes bottom support and top apron, and the two forms the annular cavity after the butt joint, the annular cavity is used for right the ball is installed, wherein, the cross-sectional profile of annular cavity is for being greater than the arc structure of 1/2 circles, the open end confession of arc structure the ball partially expose with bowl body contact.
Further, the turning block is magnetic structure, is provided with the spherical surface recess that is less than 1/2 sphere on it, the settlement position of the bowl body is fixed with the spherical hinge seat, the spherical hinge seat is magnetic structure equally, and is provided with the spherical surface recess that is less than 1/2 sphere on it, the spherical hinge seat with there is the metal ball between the turning block, the spherical surface recess magnetism laminating of the two respectively.
Further, agitating unit is body of rod structure, the fixing base includes first clamp splice and second clamp splice, and the two passes through the connecting piece to be connected, and be provided with between be used for right the body of rod carries out the part of centre gripping.
Through the technical scheme of the invention, the following technical effects can be realized:
according to the invention, through the control of the stirring track, the stable support of the bowl body and the multi-level arrangement, the uniformity of the stirring process can be improved, the stirred liquid is directly poured into the filter screen at the bottom through the shielding cover for filtering, the residual liquid on the inner wall of the shielding cover can have the same time for entering the filter screen in the static process, and the liquid is poured into the filter structure after being stirred, so that the accuracy is better, the filter screen is slowly removed after the liquid is static on the filter screen, the undissolved medicine can be more effectively filtered, and the possibility that solid particles pass through the filter screen is reduced compared with an impacting pouring mode, so that the detection accuracy is effectively ensured.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments described in the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic view of the structure of a device for measuring solubility of a food or drug in accordance with the present invention;
FIG. 2 is a sectional view of the device for measuring solubility of a food drug in accordance with the present invention;
FIG. 3 is an enlarged view of a portion of FIG. 2 at A;
FIG. 4 is a schematic view of the shield of FIG. 3 after changing its operating position;
FIG. 5 is a schematic view of the connection of the dissolution vessel to the bowl support structure and rotation means;
FIG. 6 is a partial enlarged view of FIG. 5 at B;
FIG. 7 is a schematic structural view of a bowl support structure;
FIG. 8 is an enlarged view of a portion of FIG. 7 at C;
FIG. 9 is a schematic structural view of a power end;
FIG. 10 is a partial cross-sectional view of a screen;
FIG. 11 is an enlarged view of a portion of FIG. 5 at D;
FIG. 12 is a schematic view of the fixing base;
reference numerals: 1. a dissolution vessel; 11. a bowl body; 111. a spherical hinge seat; 12. filtering with a screen; 121. a frame; 122. a grip portion; 13. a shield cover; 14. a sealing retainer ring; 2. a stirring device; 3. a work table; 31. a rotating device; 311. rotating the block; 312. a guide bar; 313. a slider; 314. a first link; 315. a second link; 32. a bowl body support structure; 321. a ball bearing; 322. a bottom support; 323. a top cover plate; 33. a fixed seat; 331. a first clamping block; 332. and a second clamping block.
Detailed Description
The invention is further described below with reference to the accompanying drawings. The following examples are only for illustrating the technical solutions of the present invention more clearly, and the protection scope of the present invention is not limited thereby.
In the description of the present invention, it should be noted that the orientations or positional relationships indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like are based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; either directly or indirectly through intervening media, or may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art. This embodiment is written in a progressive manner.
As shown in fig. 1 to 8, a device for detecting and analyzing solubility of food and drug comprises: a dissolving container 1, a stirring device 2 and a workbench 3; the dissolving container 1 comprises a bowl body 11, a filter screen 12 and a shielding cover 13 from outside to inside; the inner surface and the outer surface of the bowl body 11 are concentric hemispheres, and the filter screen 12 is attached to at least the bottom of the inner surface of the bowl body 11 and can be separated from the inner surface and the outer surface; the shielding cover 13 is rotatably connected with the bowl body 11, has a hemispherical inner surface concentric with the inner surface of the bowl body 11, and at least has a first working position for containing liquid and shielding the filter screen 12, and a second working position for pouring the liquid into the bowl body 11 and shielding the open end of the bowl body 11. The workbench 3 comprises a rotating device 31, a bowl body supporting structure and a fixed seat 33; the rotating device 31 comprises a power end and a rotating block 311 driven by the power end to move in a circular track in a horizontal plane, and the rotating block 311 is connected with the outer surface of the bowl body 11 at a position deviated from the bottommost part through a spherical hinge; the bowl body supporting structure is provided with a plurality of balls 321 which are horizontally and annularly attached and distributed, and each ball 321 rotates around the spherical center of the ball 321 and is attached to the outer surface of the bowl body 11; the fixing seat 33 fixes the stirring device 2 and enables the stirring device 2 to be adjustable in height.
According to the invention, the bowl body 11 can obtain a rotating motion form under the support of the bowl body support structure through the power end and the rotating block 311 connected with the power end, and the medicament in the bowl body 11 can form an annular stirring track in the relative rotation process of the bowl body 11 only by arranging the stirring point of the stirring device 2 to deviate from the symmetrical center of the bowl body 11, and the rotation of the bowl body 11 is used for accelerating the stirring and dissolving in the process. The ball 321 supports the bowl 11 directly in the ring body formed by the bowl in the fixing process, so that the use of a connecting piece is avoided, and the bowl 11 is stably supported by rotation. In the stirring process, as shown in fig. 3, the shielding cover 13 is located at the first working position, so as to prevent the stirring device 2 from damaging the filter screen 12, and the shielding cover can be attached to the stirring device 2 or arranged at intervals; after the stirring is completed, as shown in fig. 4, the bowl body is rotated to a second working position, wherein the contained liquid flows into the bowl body 11, and the flowing-in action must be realized through the filter screen 12 in the rotating process of the shielding cover 13, and after the liquid is completely transferred, the shielding cover 13 is in the second working position to carry out sealing protection on the liquid, so as to avoid the influence of the external environment on the liquid; after standing, when there is an undissolved portion, which remains on the screen 12, the amount of undissolved residue can be determined by removing the screen 12 and weighing it.
In the above process, the speed and time of the whole stirring can be manually set according to the type of the medicine. The adjustment of the height of the stirring device 2 can be adaptively adjusted according to the conversion between the height of the bowl body 11 and the position of the shielding cover 13, and the time for standing the liquid after stirring to obtain the precipitate can be specifically set.
As a preferable example of the above embodiment, as shown in fig. 9, the power end includes: a guide bar 312, a slider 313, a first link 314, and a second link 315; the guide rod 312 is fixedly arranged, the sliding block 313 slides along the guide rod 312, wherein one end of the first connecting rod 314 is hinged with one end of the second connecting rod 315, the other end of the first connecting rod 314 is hinged with the guide rod 312, the other end of the second connecting rod 315 is hinged with the sliding block 313, the length of the second connecting rod 315 is larger than that of the first connecting rod 314, and the rotating block 311 is connected with the hinged position of the first connecting rod 314 and the second connecting rod 315.
During operation, the second link 315 is moved and rotated by the movement of the slider 313 relative to the guide rod 312, so that the first link 314 is rotated around a set point by one end of the first link 314. Therefore, in the stirring process, only by applying force to the first link 314 or the slider 313 manually, the rotating block 311 connected with the hinged position of the first link 314 and the second link 315 can be ensured to obtain a stable rotating track, and the uniformity of the stirring action is ensured, so that the structure of the bowl body 11 can be stirred by the relatively consistent stirring action to ensure that the liquid and solid mixture in the bowl body is fully dissolved. In the process of stirring, compared with the control of the rotary motion, the artificial motion is limited to the linear motion of the sliding block 313 or the motion of the second connecting rod 315 under the limitation of the sliding block 313 and the first connecting rod 314, so that the stable control is more easily obtained, and the difficulty of operation is reduced.
As shown in fig. 10 and 11, the filter 12 preferably includes a net body and a frame 121, the net body is fixed by the frame 121, the frame 121 is attached to the inner wall of the bowl 11, a stopper is partially disposed on the inner wall of the bowl 11 for limiting the height of the frame 121, the frame 121 is retracted inward relative to the edge of the bowl 11, and the bowl 11 is rotatably connected to the shielding cover 13 through a portion higher than the frame 121. Wherein, the edge of the frame 121 is provided with a protruding holding portion 122, and the edge of the bowl body 11 is provided with a notch for leading out the holding portion 122.
In the stirring process, the net body is protected by the shielding cover 13 to avoid damage caused by the stirring device 2, the frame 121 can conveniently drive the net body to enter and exit the bowl body 11 through the transformation of the position of the shielding cover 13, the whole dissolving container 1 is convenient to clean and maintain, the rotation of the shielding cover 13 can realize the liquid pouring, and the purpose of filtering through the filter screen 12 is achieved.
As shown in fig. 12, a gasket 14 is provided on the edge of the bowl 11, and the gasket 14 is attached to the shield 13. By means of the sealing collar 14, the gap between the bowl 11 and the shield 13 is effectively sealed, in particular, contamination during standstill is avoided. Preferably the gasket 14 is removable for cleaning. Wherein, the sealing retainer ring 14 is preferably attached to the frame 121, so as to ensure the stability of the position of the frame 121.
As an optimized way of constructing the bowl 11, as shown in fig. 3, 4, 7 and 8, the bowl supporting structure includes a bottom support 322 and a top cover plate 323, which are butted to form an annular cavity for mounting the balls 321, wherein the cross-sectional profile of the annular cavity is an arc structure with a circle larger than 1/2, and the open end of the arc structure is used for partially exposing the balls 321 to contact the bowl 11. The above structure facilitates the installation of the balls 321, and the bottom support 322 and the top cover plate 323 are connected by a connecting member, which facilitates the disassembly and assembly.
As a preferred example of the above embodiment, the rotating block 311 is of a magnetic structure, and is provided with a spherical groove smaller than 1/2 spherical surface, as shown in fig. 6, a spherical hinge seat 111 is fixed at a set position of the bowl body 11, the spherical hinge seat 111 is also of a magnetic structure, and is provided with a spherical groove smaller than 1/2 spherical surface, and a metal ball is arranged between the spherical hinge seat 111 and the rotating block 311, and the spherical grooves of the two are respectively magnetically attached. The ball hinge seat 111 can be fixed with the bowl body 11 through various modes such as bonding or connecting piece connection, the process of connection is established between the ball hinge seat 111 and the rotating block 311, only the metal ball needs to be adsorbed in the spherical groove of the rotating block 311 at first, then the bowl body 11 is installed relative to the bowl body supporting structure, the establishment of the ball hinge can be realized through the bottom hinge seat and the metal ball in a laminating manner, in the process of removing the bowl body 11, only the magnetic contact needs to be removed, the bowl is convenient and rapid, and the bowl body 11 is convenient to clean and use.
In order to facilitate the height adjustment, the stirring device 2 is a rod structure, and the fixing base 33 includes a first clamping block 331 and a second clamping block 332, which are connected by a connecting member, and a portion for clamping the rod is disposed between the first clamping block 331 and the second clamping block 332. The control of the tightness is connected through the connecting piece, so that the height of the rod body structure relative to the fixed seat 33 can be adjusted, and the process is convenient and fast.
According to the invention, through the control of the stirring track, the stable support of the bowl body 11 and the multi-level arrangement, the uniformity of the stirring process can be improved, the stirred liquid is directly poured into the filter screen 12 at the bottom through the shielding cover 13 for filtering, the time for the residual liquid on the inner wall of the shielding cover 13 to enter the filter screen 12 can be ensured in the static process, the liquid is poured into the filter structure with better accuracy after the stirring is finished, and the filter screen 12 is slowly removed after the liquid is static on the filter screen 12, so that the undissolved medicine can be effectively filtered, and the possibility that solid particles pass through the filter screen 12 is reduced for the pouring mode with impact, and the detection accuracy is effectively ensured.
The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (9)
1. A food drug solubility detection and analysis device, comprising: a dissolving container (1), a stirring device (2) and a workbench (3);
the dissolving container (1) comprises a bowl body (11), a filter screen (12) and a shielding cover (13) from outside to inside; the inner surface and the outer surface of the bowl body (11) are concentric hemispheres, and the filter screen (12) is attached to at least the bottom of the inner surface of the bowl body (11) and can be separated from the bowl body; the shielding cover (13) is rotatably connected with the bowl body (11), has a hemispherical inner surface concentric with the inner surface of the bowl body (11), and at least has a first working position for containing liquid and shielding the filter screen (12) and a second working position for pouring the liquid into the bowl body (11) and shielding the open end of the bowl body (11);
the workbench (3) comprises a rotating device (31), a bowl body supporting structure (32) and a fixed seat (33); the rotating device (31) comprises a power end and a rotating block (311) driven by the power end to move in a circular track in a horizontal plane, and the rotating block (311) is connected with the position, deviated from the bottommost part, of the outer surface of the bowl body (11) through a spherical hinge; the bowl body supporting structure (32) is provided with a plurality of balls (321) which are horizontally and annularly attached and distributed, and each ball (321) rotates around the center of the ball and is attached to the outer surface of the bowl body (11); the fixing seat (33) fixes the stirring device (2), and the height of the stirring device (2) is adjustable.
2. The food product drug solubility detection assay device of claim 1 wherein the power end comprises: a guide rod (312), a slider (313), a first link (314), and a second link (315);
the guide rod (312) is fixedly arranged, the sliding block (313) slides along the guide rod (312), one end of the first connecting rod (314) is hinged to one end of the second connecting rod (315), the other end of the first connecting rod (314) is hinged to the guide rod (312), the other end of the second connecting rod (315) is hinged to the sliding block (313), the length of the second connecting rod (315) is larger than that of the first connecting rod (314), and the rotating block (311) is connected with the hinged position of the first connecting rod (314) and the second connecting rod (315).
3. The food and drug solubility detection and analysis device according to claim 1 or 2, wherein the filter screen (12) comprises a screen body and a frame (121), the screen body is fixed through the frame (121), the frame (121) is attached to the inner wall of the bowl body (11), a stopper is locally arranged on the inner wall of the bowl body (11) and used for limiting the height of the frame (121), the frame (121) retracts inwards relative to the edge of the bowl body (11), and the bowl body (11) is rotatably connected with the shielding cover (13) through a part higher than the frame (121).
4. The food drug solubility detection and analysis device according to claim 3, wherein a protruding holding part (122) is arranged on the edge of the frame (121), and a notch for leading out the holding part (122) is arranged on the edge of the bowl body (11).
5. The food drug solubility detection and analysis device according to claim 4, characterized in that a sealing collar (14) is arranged at the edge of the bowl body (11), and the sealing collar (14) is attached to the shielding cover (13).
6. The food drug solubility detection and analysis device of claim 5, wherein the sealing collar (14) is attached to the frame (121).
7. The food drug solubility detection and analysis device of claim 1, wherein the bowl support structure (32) comprises a bottom support (322) and a top cover plate (323) which are butted to form an annular cavity for mounting the ball (321), wherein the annular cavity has a cross-sectional profile of an arc structure with a circle larger than 1/2, and the open end of the arc structure is used for partially exposing the ball (321) to contact the bowl (11).
8. The food and drug solubility detection and analysis device according to claim 1, wherein the rotating block (311) is of a magnetic structure, a spherical groove smaller than 1/2 spherical surface is formed in the rotating block, the bowl body (11) is fixed with a spherical hinge seat (111) at a set position, the spherical hinge seat (111) is of a magnetic structure, a spherical groove smaller than 1/2 spherical surface is formed in the spherical hinge seat (111), and a metal ball is arranged between the spherical hinge seat (111) and the rotating block (311) and is magnetically attached to the spherical grooves of the two.
9. The food and drug solubility detection and analysis device according to claim 1, wherein the stirring device (2) is a rod structure, and the fixing base (33) comprises a first clamping block (331) and a second clamping block (332) which are connected by a connecting piece, and a portion for clamping the rod structure is arranged between the first clamping block and the second clamping block.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110069654.XA CN112858085B (en) | 2021-01-19 | 2021-01-19 | Food drug solubility detection and analysis device |
| PCT/CN2021/113425 WO2022156207A1 (en) | 2021-01-19 | 2021-08-19 | Device for test and analysis of solubility of oral drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110069654.XA CN112858085B (en) | 2021-01-19 | 2021-01-19 | Food drug solubility detection and analysis device |
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| Publication Number | Publication Date |
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| CN112858085A CN112858085A (en) | 2021-05-28 |
| CN112858085B true CN112858085B (en) | 2021-11-02 |
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| CN202110069654.XA Active CN112858085B (en) | 2021-01-19 | 2021-01-19 | Food drug solubility detection and analysis device |
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| WO (1) | WO2022156207A1 (en) |
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| CN112858085B (en) * | 2021-01-19 | 2021-11-02 | 竹简云(天津)生物科技有限公司 | Food drug solubility detection and analysis device |
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