WO2022144044A1 - 一种天冬氨酸铜配合物及其应用 - Google Patents
一种天冬氨酸铜配合物及其应用 Download PDFInfo
- Publication number
- WO2022144044A1 WO2022144044A1 PCT/CN2022/078264 CN2022078264W WO2022144044A1 WO 2022144044 A1 WO2022144044 A1 WO 2022144044A1 CN 2022078264 W CN2022078264 W CN 2022078264W WO 2022144044 A1 WO2022144044 A1 WO 2022144044A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- copper
- feed
- compound
- asp
- animal
- Prior art date
Links
- GUPMWVRHEBLNMF-DKWTVANSSA-N (2s)-2-aminobutanedioic acid;copper Chemical compound [Cu].OC(=O)[C@@H](N)CC(O)=O GUPMWVRHEBLNMF-DKWTVANSSA-N 0.000 title abstract 5
- 241001465754 Metazoa Species 0.000 claims abstract description 77
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims abstract description 66
- 239000010949 copper Substances 0.000 claims abstract description 51
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 47
- 229910052802 copper Inorganic materials 0.000 claims abstract description 47
- 239000000203 mixture Substances 0.000 claims abstract description 46
- 239000000126 substance Substances 0.000 claims abstract description 39
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 claims abstract description 34
- CKLJMWTZIZZHCS-UHFFFAOYSA-N Aspartic acid Chemical compound OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 claims abstract description 19
- 244000144977 poultry Species 0.000 claims abstract description 16
- 244000144972 livestock Species 0.000 claims abstract description 14
- LHBCBDOIAVIYJI-DKWTVANSSA-L copper;(2s)-2-aminobutanedioate Chemical compound [Cu+2].[O-]C(=O)[C@@H](N)CC([O-])=O LHBCBDOIAVIYJI-DKWTVANSSA-L 0.000 claims description 77
- 241000287828 Gallus gallus Species 0.000 claims description 25
- 239000003674 animal food additive Substances 0.000 claims description 24
- 235000019730 animal feed additive Nutrition 0.000 claims description 17
- 238000002360 preparation method Methods 0.000 claims description 17
- 235000013305 food Nutrition 0.000 claims description 14
- 239000003085 diluting agent Substances 0.000 claims description 10
- 239000013589 supplement Substances 0.000 claims description 9
- 239000007952 growth promoter Substances 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 3
- 241000272525 Anas platyrhynchos Species 0.000 claims description 2
- 241000282898 Sus scrofa Species 0.000 claims 1
- 238000009395 breeding Methods 0.000 abstract description 19
- 230000001488 breeding effect Effects 0.000 abstract description 19
- 238000003975 animal breeding Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 description 68
- 238000012360 testing method Methods 0.000 description 42
- 229960005261 aspartic acid Drugs 0.000 description 32
- 230000000694 effects Effects 0.000 description 29
- 239000000047 product Substances 0.000 description 25
- 241000282887 Suidae Species 0.000 description 23
- 235000003704 aspartic acid Nutrition 0.000 description 23
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 22
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 18
- 229910000365 copper sulfate Inorganic materials 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- 235000013330 chicken meat Nutrition 0.000 description 14
- 229940125904 compound 1 Drugs 0.000 description 14
- 235000013594 poultry meat Nutrition 0.000 description 14
- 238000000034 method Methods 0.000 description 13
- 239000002994 raw material Substances 0.000 description 13
- JZCCFEFSEZPSOG-UHFFFAOYSA-L copper(II) sulfate pentahydrate Chemical compound O.O.O.O.O.[Cu+2].[O-]S([O-])(=O)=O JZCCFEFSEZPSOG-UHFFFAOYSA-L 0.000 description 12
- 241000272517 Anseriformes Species 0.000 description 11
- 229910001431 copper ion Inorganic materials 0.000 description 11
- CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 description 10
- 235000019688 fish Nutrition 0.000 description 10
- 239000007787 solid Substances 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 241000251468 Actinopterygii Species 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 229940125782 compound 2 Drugs 0.000 description 9
- 235000016709 nutrition Nutrition 0.000 description 9
- 229940126214 compound 3 Drugs 0.000 description 8
- 235000013312 flour Nutrition 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 230000009102 absorption Effects 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 7
- 239000000654 additive Substances 0.000 description 7
- 230000000996 additive effect Effects 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 235000019786 weight gain Nutrition 0.000 description 7
- 229940125898 compound 5 Drugs 0.000 description 6
- 238000001035 drying Methods 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 230000004584 weight gain Effects 0.000 description 6
- 241000283973 Oryctolagus cuniculus Species 0.000 description 5
- 240000008042 Zea mays Species 0.000 description 5
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 5
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 239000000969 carrier Substances 0.000 description 5
- 235000005822 corn Nutrition 0.000 description 5
- 229910052500 inorganic mineral Inorganic materials 0.000 description 5
- 235000010755 mineral Nutrition 0.000 description 5
- 239000011707 mineral Substances 0.000 description 5
- ZUNFPBNHELLPPP-UHFFFAOYSA-N 3-[4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy-N-[2-(dimethylamino)ethyl]benzamide Chemical compound NCC1=CC(=NC(=C1)C(F)(F)F)OC=1C=C(C(=O)NCCN(C)C)C=CC=1 ZUNFPBNHELLPPP-UHFFFAOYSA-N 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 4
- 241000272201 Columbiformes Species 0.000 description 4
- 241000283086 Equidae Species 0.000 description 4
- 241001494479 Pecora Species 0.000 description 4
- 208000005374 Poisoning Diseases 0.000 description 4
- WGCOQYDRMPFAMN-ZDUSSCGKSA-N [(3S)-3-[4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl]oxypiperidin-1-yl]-pyrimidin-5-ylmethanone Chemical compound NCC1=CC(=NC(=C1)C(F)(F)F)O[C@@H]1CN(CCC1)C(=O)C=1C=NC=NC=1 WGCOQYDRMPFAMN-ZDUSSCGKSA-N 0.000 description 4
- 229940024606 amino acid Drugs 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 4
- 239000006227 byproduct Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- 230000003247 decreasing effect Effects 0.000 description 4
- 238000000921 elemental analysis Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 231100000572 poisoning Toxicity 0.000 description 4
- 230000000607 poisoning effect Effects 0.000 description 4
- 239000012265 solid product Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- -1 superoxide ions Chemical class 0.000 description 4
- 241000252203 Clupea harengus Species 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 125000000570 L-alpha-aspartyl group Chemical group [H]OC(=O)C([H])([H])[C@]([H])(N([H])[H])C(*)=O 0.000 description 3
- 241000282339 Mustela Species 0.000 description 3
- 240000007594 Oryza sativa Species 0.000 description 3
- 235000007164 Oryza sativa Nutrition 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 238000009360 aquaculture Methods 0.000 description 3
- 244000144974 aquaculture Species 0.000 description 3
- 235000021053 average weight gain Nutrition 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 235000019514 herring Nutrition 0.000 description 3
- 235000013372 meat Nutrition 0.000 description 3
- 235000009566 rice Nutrition 0.000 description 3
- 235000002639 sodium chloride Nutrition 0.000 description 3
- 238000004611 spectroscopical analysis Methods 0.000 description 3
- 239000011573 trace mineral Substances 0.000 description 3
- 235000013619 trace mineral Nutrition 0.000 description 3
- JIMDQTNPLVRAES-UHFFFAOYSA-N 3-[4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy-N-(oxetan-3-yl)benzamide Chemical compound NCC1=CC(=NC(=C1)C(F)(F)F)OC=1C=C(C(=O)NC2COC2)C=CC=1 JIMDQTNPLVRAES-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 108010068370 Glutens Proteins 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 241000286209 Phasianidae Species 0.000 description 2
- 235000019779 Rapeseed Meal Nutrition 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 2
- 229940062672 calcium dihydrogen phosphate Drugs 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 150000001879 copper Chemical class 0.000 description 2
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000012065 filter cake Substances 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 210000004211 gastric acid Anatomy 0.000 description 2
- 235000021312 gluten Nutrition 0.000 description 2
- 239000010903 husk Substances 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 235000019691 monocalcium phosphate Nutrition 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 235000006180 nutrition needs Nutrition 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000005416 organic matter Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 239000004456 rapeseed meal Substances 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 235000012424 soybean oil Nutrition 0.000 description 2
- 239000003549 soybean oil Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000002411 thermogravimetry Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- JZCAHRHZFBBFRZ-WCCKRBBISA-N (2s)-2-amino-4-methylsulfanylbutanoic acid;copper Chemical compound [Cu].CSCC[C@H](N)C(O)=O JZCAHRHZFBBFRZ-WCCKRBBISA-N 0.000 description 1
- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 description 1
- MZSAMHOCTRNOIZ-UHFFFAOYSA-N 3-[4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy-N-phenylaniline Chemical compound NCC1=CC(=NC(=C1)C(F)(F)F)OC=1C=C(NC2=CC=CC=C2)C=CC=1 MZSAMHOCTRNOIZ-UHFFFAOYSA-N 0.000 description 1
- JXSRRBVHLUJJFC-UHFFFAOYSA-N 7-amino-2-methylsulfanyl-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile Chemical compound N1=CC(C#N)=C(N)N2N=C(SC)N=C21 JXSRRBVHLUJJFC-UHFFFAOYSA-N 0.000 description 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 208000031295 Animal disease Diseases 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 235000019743 Choline chloride Nutrition 0.000 description 1
- 241001454694 Clupeiformes Species 0.000 description 1
- 102100037529 Coagulation factor V Human genes 0.000 description 1
- 241000252185 Cobitidae Species 0.000 description 1
- 206010010957 Copper deficiency Diseases 0.000 description 1
- QPLDLSVMHZLSFG-UHFFFAOYSA-N Copper oxide Chemical compound [Cu]=O QPLDLSVMHZLSFG-UHFFFAOYSA-N 0.000 description 1
- 239000005751 Copper oxide Substances 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 108010014172 Factor V Proteins 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 235000019733 Fish meal Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
- 235000019738 Limestone Nutrition 0.000 description 1
- 241001124569 Lycaenidae Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 102000014171 Milk Proteins Human genes 0.000 description 1
- 108010011756 Milk Proteins Proteins 0.000 description 1
- 239000006057 Non-nutritive feed additive Substances 0.000 description 1
- JVMRPSJZNHXORP-UHFFFAOYSA-N ON=O.ON=O.ON=O.N Chemical compound ON=O.ON=O.ON=O.N JVMRPSJZNHXORP-UHFFFAOYSA-N 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 235000019764 Soybean Meal Nutrition 0.000 description 1
- 108010073771 Soybean Proteins Proteins 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- XKMRRTOUMJRJIA-UHFFFAOYSA-N ammonia nh3 Chemical compound N.N XKMRRTOUMJRJIA-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000006053 animal diet Substances 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 229940124350 antibacterial drug Drugs 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 229940009098 aspartate Drugs 0.000 description 1
- 239000005667 attractant Substances 0.000 description 1
- 235000014590 basal diet Nutrition 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- ODWXUNBKCRECNW-UHFFFAOYSA-M bromocopper(1+) Chemical compound Br[Cu+] ODWXUNBKCRECNW-UHFFFAOYSA-M 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 230000031902 chemoattractant activity Effects 0.000 description 1
- SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 description 1
- 229960003178 choline chloride Drugs 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 235000014987 copper Nutrition 0.000 description 1
- 229940116318 copper carbonate Drugs 0.000 description 1
- 229910000431 copper oxide Inorganic materials 0.000 description 1
- XTVVROIMIGLXTD-UHFFFAOYSA-N copper(II) nitrate Chemical compound [Cu+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O XTVVROIMIGLXTD-UHFFFAOYSA-N 0.000 description 1
- OMZSGWSJDCOLKM-UHFFFAOYSA-N copper(II) sulfide Chemical compound [S-2].[Cu+2] OMZSGWSJDCOLKM-UHFFFAOYSA-N 0.000 description 1
- OPQARKPSCNTWTJ-UHFFFAOYSA-L copper(ii) acetate Chemical compound [Cu+2].CC([O-])=O.CC([O-])=O OPQARKPSCNTWTJ-UHFFFAOYSA-L 0.000 description 1
- DGOQVPGXOPZESE-XRIGFGBMSA-N copper;(2s)-2,6-diaminohexanoic acid;hydrochloride Chemical compound Cl.[Cu].NCCCC[C@H](N)C(O)=O DGOQVPGXOPZESE-XRIGFGBMSA-N 0.000 description 1
- GEZOTWYUIKXWOA-UHFFFAOYSA-L copper;carbonate Chemical compound [Cu+2].[O-]C([O-])=O GEZOTWYUIKXWOA-UHFFFAOYSA-L 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- ALKZAGKDWUSJED-UHFFFAOYSA-N dinuclear copper ion Chemical class [Cu].[Cu] ALKZAGKDWUSJED-UHFFFAOYSA-N 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000004467 fishmeal Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 235000019138 food restriction Nutrition 0.000 description 1
- 239000004459 forage Substances 0.000 description 1
- 235000013569 fruit product Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000000077 insect repellent Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 239000006028 limestone Substances 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229940037627 magnesium lauryl sulfate Drugs 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- HBNDBUATLJAUQM-UHFFFAOYSA-L magnesium;dodecyl sulfate Chemical compound [Mg+2].CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCOS([O-])(=O)=O HBNDBUATLJAUQM-UHFFFAOYSA-L 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 235000019741 micromineral premix Nutrition 0.000 description 1
- 235000021239 milk protein Nutrition 0.000 description 1
- 239000002366 mineral element Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000020939 nutritional additive Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000000467 phytic acid Substances 0.000 description 1
- 229940068041 phytic acid Drugs 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000033458 reproduction Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
- LIVNPJMFVYWSIS-UHFFFAOYSA-N silicon monoxide Chemical class [Si-]#[O+] LIVNPJMFVYWSIS-UHFFFAOYSA-N 0.000 description 1
- 229910052814 silicon oxide Inorganic materials 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 229940001941 soy protein Drugs 0.000 description 1
- 239000004455 soybean meal Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 239000011232 storage material Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000005891 transamination reaction Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000010455 vermiculite Substances 0.000 description 1
- 229910052902 vermiculite Inorganic materials 0.000 description 1
- 235000019354 vermiculite Nutrition 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 235000015099 wheat brans Nutrition 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/08—Copper compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/76—Metal complexes of amino carboxylic acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/20—Animal feeding-stuffs from material of animal origin
- A23K10/22—Animal feeding-stuffs from material of animal origin from fish
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/20—Animal feeding-stuffs from material of animal origin
- A23K10/24—Animal feeding-stuffs from material of animal origin from blood
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/26—Compounds containing phosphorus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
Definitions
- Copper is one of the essential trace elements for animals, the key center and activity center of some enzymes in animals, the cofactor of various oxidase and the constituents of coagulation factor V and MT, and maintains normal hematopoietic function, bone, blood vessels and blood vessels.
- K.Kaemmerer reported that copper deficiency can seriously delay the growth of animals, and resupply of copper can quickly restore the growth of animals.
- the nutritional requirement of copper for animals is 5mg/kg to 8mg/kg.
- inorganic copper Since a study in 1945 found that high copper can significantly improve the growth performance of pigs, 200mg/kg ⁇ 250mg/kg of high copper raw materials have been used in the breeding of young piglets to improve their growth performance and shorten the breeding cycle.
- the availability of inorganic copper is related to its solubility. High solubility is stronger than low solubility.
- copper sulfate has the best effect, which is almost the same as that of organic copper and chelated copper. Therefore, inorganic copper is especially cost-effective. It is the main source of copper sulfate that becomes the main source of high copper in piglet feed.
- a large amount of copper ions released in gastric acid is absorbed due to the presence of phytic acid or fiber in the diet, so that only a small amount of copper ions can reach the middle and rear of the small intestine to play an antimicrobial role or be absorbed by the small intestine into the body to exert its biological effect. Therefore, it is necessary to add high concentrations of copper ions to the feed to achieve the effect of antibacterial and growth promotion. Copper exceeding the physiological limit brings many side effects, such as high copper damage to body organs, excessive residues in organs affecting food safety, interfering with the absorption of other nutrients, and unused copper polluting the environment through feces.
- Aspartic acid is not essential to mammals and can be produced from oxaloacetate by transamination.
- Objects of the present application include providing a copper aspartate complex that is safe and has improved performance throughout the life of an animal.
- the purpose of this application also includes providing the application of the copper aspartate complex and its feed composition in the preparation of animal feed additives.
- the purpose of the present application also includes providing the application of the copper aspartate complex and its feed composition in preparing animal feed.
- the present application also aims to provide a method for improving animal production performance.
- the present application provides a copper aspartate complex with a chemical structure of [(Cu(II))(Asp)(H 2 O) m ] ⁇ (H 2 O) n , wherein Asp is L -Asp or DL-Asp, m is any integer from 0-10, n is any value from 0-10.
- the chemical structure of the copper aspartate complex is any of the following:
- the present application also provides a feed composition, the composition comprising at least one of the copper aspartate complexes provided by the present invention and at least one of feed, pharmacy or food acceptable excipients .
- the feed composition further comprises additional animal feed additives.
- the additional animal feed additives include nutritional feed additives, non-nutritive feed additives and pharmaceutical feed additives.
- the feed composition further comprises feed raw materials.
- the present application also provides a copper aspartate complex with a chemical structure of [(Cu(II))(Asp)(H 2 O) m ] ⁇ (H 2 O) n and a feed composition thereof Application in the preparation of animal feed additives.
- the animals are livestock, poultry, aquatic animals or pets at various growth stages.
- the present application also provides a copper aspartate complex with a chemical structure of [(Cu(II))(Asp)(H 2 O) m ] ⁇ (H 2 O) n and a feed composition thereof Application in the preparation of animal feed.
- the animals are livestock, poultry, aquatic animals or pets at various growth stages.
- the present application also provides a method for improving animal production performance, comprising: comprising the chemical structure provided by the present invention as [(Cu(II))(Asp)(H 2 O) m ] ⁇ (H 2 O) n copper aspartate complex and feed composition thereof for animal feeding; alternatively, the chemical structure is [(Cu(II))(Asp)(H 2 O) m ] ⁇ (H Copper aspartate complexes of 2 O) n , or feed compositions or feed additives comprising the chemical structure [(Cu(II))(Asp)(H 2 O) m ] ⁇ (H 2 O) n
- the amount of the copper aspartate complex, or the feed composition or the animal feed additive is calculated as copper element and the weight of the animal diet is The standard is 5 mg/kg to 300 mg/kg.
- the present invention finds that the copper aspartate complex whose chemical structure is [(Cu(II))(Asp)(H 2 O) m ] ⁇ (H 2 O) n is used in breeding animals.
- the required amount of use can promote the growth of livestock and poultry at all stages of the growth cycle, and the growth performance of animals is normal when used in high doses, which overcomes the harm caused by excessive use of high-dose inorganic copper in the breeding industry. And other issues.
- any embodiment of any aspect of the present application may be combined with other embodiments provided that there is no conflict between them.
- any technical feature may be applicable to the technical feature in other embodiments, as long as there is no contradiction between them.
- FIG. 1 is an infrared diffraction pattern of a copper aspartate complex whose chemical formula is [Cu(L-Asp)(H 2 O) 2 ].
- FIG. 2 is an infrared diffraction pattern of a raw material mixture for preparing a copper aspartate complex whose chemical formula is [Cu(L-Asp)(H 2 O) 2 ].
- the invention provides a copper aspartate complex whose chemical structure is [(Cu(II))(Asp)(H 2 O) m ] ⁇ (H 2 O) n , wherein Asp is L-Asp or DL -Asp, m is any integer from 0-10, n is any value from 0-10.
- the “complex” involved in the present invention refers to a copper ion of a certain soluble copper salt and an aspartate ion (chemical structure is -OOC - CH 2 -CH(NH 2 )-COO - , referred to in the present invention as ""
- Asp Asp
- water molecules external conditions and internal conditions cause stable substances formed by covalent bonds and/or non-covalent intermolecular forces in a certain chemical molar equivalent and/or non-stoichiometric combination.
- Aspartic acid is also called aspartic acid, its chemical name is aminosuccinic acid, its English name is Aspartic Acid, and its chemical structure is HOOC-CH 2 -CH(NH 2 )-COOH.
- Aspartic acid has asymmetric carbon atoms (denoted as "- * CH(NH 2 )-"), which is optically active. Due to the different arrangement positions in space, it is divided into L-type and D type Enantiomers of each other.
- the racemate of an optically inactive aspartic acid is composed of an equal amount of D-type and L-type aspartic acid, and is recorded as DL type Can be aspartic acid racemic mixture or racemic aspartic acid.
- the aspartic acid racemic mixture is a crystalline mixture of equal amounts of D- and L-form aspartic acids, and the racemic aspartic acid is D-form and L-form alternating in the crystal lattice Arranged compounds.
- the copper aspartate complex can be prepared by the following scheme:
- the sodium hydroxide may be replaced by an equimolar equivalent of potassium hydroxide.
- the copper sulfate pentahydrate can be replaced by equimolar equivalents of copper chloride and its hydrate, copper bromide and its hydrate, copper nitrate and its hydrate, and the like.
- the stirring reaction time is 0-4 hours, and stirring is performed at a low speed, a medium speed or a fast speed, and the solid product [(Cu(II))(Asp)(H 2 O) m ] ⁇ n( In H 2 O), m is any integer from 0 to 10, and n is any value from 0 to 10.
- m is any integer from 0-2.
- the drying by heating is a drying method under reduced pressure
- the heating temperature is 60-110° C.
- the pressure in the drying box is 0-0.1 MPa
- the solid product [(Cu(II))(Asp)(H 2 O) m ] ⁇ (H 2 O) n is a copper aspartate complex in which n is any value selected from 0-1.
- the drying by heating is a drying method under reduced pressure
- the heating temperature is 110-150° C.
- the pressure in the drying box is 0-0.1 MPa
- the solid product [(Cu(II))(Asp)(H 2 O) m ] ⁇ (H 2 O) n is a copper aspartate complex in which m and n are independently 0.
- the 1 stoichiometric aspartic acid is L-aspartic acid
- the product is [(Cu(II))(L-Asp)(H 2 O) m ] ⁇ (H 2 O) n .
- the 1 stoichiometric aspartic acid is DL-type aspartic acid, and the product is [(Cu(II))(DL-Asp)(H 2 O) m ] ⁇ (H 2 O) n .
- the structure of the copper aspartate complex is any one of the following:
- the present invention provides a feed composition comprising at least one of the copper aspartate complexes and at least one of feed, pharmaceutically or food acceptable auxiliary materials.
- composition refers to a compound collective comprising one or more compounds constituting an active ingredient.
- feed, pharmaceutical or food acceptable in the present invention means that the substance or composition must be chemically or toxicologically suitable for the composition of feed, medicine, food or edible farm animals.
- the adjuvants include carriers, diluents, excipients, vehicles or combinations thereof commonly used in the feed, pharmaceutical or food industries.
- the “carrier” of the present invention refers to a feedable substance that can carry active ingredients, improve its dispersibility, and have good chemical stability and adsorption, and is divided into organic carriers and inorganic carriers.
- the organic carrier is generally a material containing a lot of crude fiber, including but not limited to corn flour, corncob flour, wheat bran, rice husk flour, defatted rice bran, traditional bran, corn stalk flour, peanut husk flour and the like.
- the inorganic carriers are generally minerals, mainly divided into calcium salts and silicon oxides, which are used for the preparation of trace element premixes, including but not limited to calcium carbonate, silicate, vermiculite, zeolite, seaweed, etc. Foam, etc.
- the "diluent” involved in the present invention refers to a substance that evenly distributes the additive raw material in the material, and dilutes the high-concentration additive raw material into a low-concentration premix or premix, which can separate trace components from each other and reduce active components. The interaction between them can increase the stability of the active ingredients without affecting the physicochemical properties of the related substances.
- the types of diluents are divided into organic diluents and inorganic diluents.
- Common organic diluents include but are not limited to corn flour, degerminated corn flour, dextrose (glucose), sucrose, semolina with bran, fried soybeans Powder, secondary powder, corn gluten meal, etc.
- commonly used inorganic diluents include but are not limited to limestone, calcium dihydrogen phosphate, shell powder, kaolin (white clay), table salt and sodium sulfate.
- the excipient is a wetting agent that induces the inherent viscosity of the substance, a binder that binds the substance, a disintegrating agent that breaks the entire sheet of the substance into many fine particles, and reduces the size of the particles.
- Retention aids for inter-friction or anti-sticking agents to prevent materials from sticking including but not limited to magnesium stearate, talc, vegetable oil, magnesium lauryl sulfate, starch, starch slurry, water, inorganic salts, dextrin, powdered sugar Wait.
- solvent refers to the solvent required for dissolving or dispersing the solid, including but not limited to water, ethanol, glycerin and the like.
- the feed composition further comprises additional animal feed additives.
- the additional animal feed additives are nutritional feed additives, general feed additives or pharmaceutical feed additives.
- the nutritional feed additive refers to a small or trace amount of substances added to compound feed to balance feed nutrients, improve feed utilization, and directly exert nutritional effects on animals, including amino acids, amino acid salts and their analogs, vitamins and retinoids. , mineral elements and their complexes (chelates), microbial enzymes or non-protein nitrogen.
- the general feed additives are also called non-nutritive additives, which refer to some non-nutritive substances added to the feed to improve feed utilization, ensure feed quality and quality, and be beneficial to animal health or metabolism, including growth promoters, Insect repellent health care agent, flavoring and food attractant, feed conditioner, feed preparation agent, feed storage agent and Chinese herbal medicine additive.
- the pharmaceutical feed additives include, but are not limited to, veterinary drug premixed substances that have the effects of preventing animal diseases, promoting animal growth and can be added to the feed for a long time and incorporated into a carrier or diluent.
- the feed composition may include feed ingredients selected from non-feed additives, such as animal, plant, microorganism or mineral feed substances that can be used for processing and making feed.
- non-feed additives such as animal, plant, microorganism or mineral feed substances that can be used for processing and making feed.
- Described animal feed raw materials are equivalent to the acceptable raw materials in feed, specifically grains and their processed products, oilseeds and their processed products, legume seeds and their processed products, tubers, roots and their processed products, other seeds, Fruit products and their processed products, forage grass, roughage and their processed products, other plants, algae and their processed products, dairy products and their by-products, terrestrial animal products and their by-products, fish, other aquatic organisms and their by-products, minerals Substances, microbial fermentation products and by-products, other feed materials and other feed substances.
- the feed composition is an additive premix, concentrated feed, compound feed, or concentrate supplement.
- the feed additive premixed feed refers to any two or more types of nutritional feed additives in mineral trace elements, vitamins, microorganisms and amino acids, and the copper aspartate complex provided by the present invention. or other feed additives, carriers and (or) diluents prepared according to a certain proportion of the homogeneous mixture, wherein the content of nutritional feed additives can meet the basic nutritional needs of the specific physiological stage of the animal, the copper aspartate complex is in The added amount of compound feed, concentrate supplement or animal drinking water is 5mg/kg to 300mg/kg calculated as copper element.
- the said concentrated feed refers to the feed which mainly consists of protein, minerals and feed additives prepared according to a certain proportion.
- the compound feed refers to a feed prepared by a variety of feed raw materials and feed additives according to a certain proportion according to the nutritional needs of the breeding animals.
- the concentrate supplement refers to a feed prepared by a variety of feed raw materials and feed additives according to a certain proportion in order to supplement the nutrition of herbivorous animals.
- the invention also provides the application of the copper aspartate complex and its feed composition in preparing animal feed additives.
- the copper aspartate complex and its feed composition are used in the preparation of animal feed additives, and the animal feed additives are livestock feed additives, poultry feed additives, aquaculture animal feed additives or pet food additives.
- the "animal” involved in the present invention refers to a person or a breeder who cannot synthesize inorganic matter into organic matter, and can only use organic matter as food for life activities such as ingestion, digestion, absorption, respiration, circulation, excretion, sensation, movement and reproduction. animal.
- farmed animals include poultry, livestock, aquatic animals, and other animals that are legally caught by artificial breeding, including pets.
- the poultry involved in the present invention are food-borne animals such as chickens, ducks, geese, pigeons, quails or turkeys at various growth stages;
- the livestock involved in the present invention are pigs, cattle, sheep, rabbits, Food-borne animals such as horses;
- the aquaculture animals involved in the present invention are fish, shrimp, loach, crab or eel at various growth stages; pets involved in the present invention include but are not limited to cats, dogs, rabbits and the like.
- the copper aspartate complex and its feed composition are used to prepare feed additives for livestock, including but not limited to pigs, cattle, sheep, horses, rabbits, minks, etc. at various growth stages.
- the copper aspartate complex and its feed composition are used to prepare feed additives for poultry, and the poultry includes but not limited to chickens, ducks, geese, pigeons and the like at various growth stages.
- the animal feed additive prepared with the copper aspartate complex and its feed composition is a premix, a compound premix, a water preparation or a granule.
- the present invention also provides the application of the copper aspartate complex and its feed composition in preparing animal feed, where the animal feed is livestock feed, poultry feed, aquaculture animal feed or pet feed.
- the copper aspartate complex and its feed composition are used to prepare feed for livestock, including but not limited to pigs, cattle, sheep, horses, rabbits, minks, etc. at various growth stages.
- the application of the copper aspartate complex and its feed composition is used to prepare poultry feed, and the poultry includes but is not limited to chickens, ducks, geese, pigeons, etc. at various growth stages.
- the feed prepared comprising the copper aspartate complex and its feed composition is a single feed, a concentrated feed, a compound feed, a compound premix or a concentrate supplement.
- the compound feed is full-price compound feed.
- the added amount of the copper aspartate complex in the full-price compound feed is 5 mg/kg to 300 mg/kg calculated as copper element.
- the added amount of the copper aspartate complex is 5 mg/kg to 250 mg/kg calculated as copper element.
- the livestock are pigs, cattle, sheep, horses, rabbits and minks at various growth stages, preferably pigs.
- the full-price compound feed is a full-price compound feed for poultry, and the added amount of the copper aspartate complex is 8 mg/kg-200 mg/kg in terms of copper element.
- the poultry are chickens, ducks, geese, pigeons, etc. at various growth stages, preferably chickens and ducks.
- the present invention also provides a method for improving animal production performance, comprising: feeding animals with the feed containing the copper aspartate complex; or, feeding the copper aspartate complex and its feed
- the composition or feed additive is added to the ration of the animal according to the corresponding animal growth requirements for animal feeding, and the usage amount of the copper aspartate complex, or the feed composition or the additive thereof, is calculated as copper element It is 5mg/kg ⁇ 300mg/kg.
- breeding Technical personnel with professional feeding knowledge (referred to as “breeders") know from experience that the lack of copper in the animal's diet will delay the growth and development of animals, and it is necessary to supplement the supply of copper in time to restore the normal growth and development of animals.
- breeders can freely choose different copper sources for animal consumption, and the copper sources include the copper aspartate chelate provided by the present invention and the copper aspartate complex containing the copper aspartate complex.
- the feed composition, feed or feed additive, and the breeder gives the animal food containing the copper aspartate complex in a sufficient required amount according to the nutritional requirement of the copper element for the animal at each growth stage.
- the animal food includes, but is not limited to, animal feed, feed compositions, basal diets, and the like.
- the animals are livestock at various growth stages, preferably pigs at various growth stages.
- the feed intake, average daily gain and feed reward of the test pigs were improved.
- the animals are poultry at various growth stages, preferably chickens and ducks at various growth stages.
- the animal food was used as animal food, compared with the test chickens or ducks of the copper sulfate breeding example, the aspartic acid breeding example or the control breeding example, an improvement effect appeared in the feed reward of the test chicken or duck, and when the aspartic acid was When the experimental dosage of copper complexes reached 100-300 mg/kg, no animal poisoning phenomenon similar to that of high-dose copper sulfate breeding cases occurred in the test chickens.
- the copper aspartate complex provided by the present invention can not only meet the growth needs of animals but also significantly improve the production performance of animals in terms of improving animal growth performance.
- Fig. 1 is the infrared diffraction spectrum detection result of the product
- Fig. 2 is the infrared diffraction of the mixture obtained by simply mixing the raw materials aspartic acid and copper sulfate pentahydrate required for the preparation of the product in the above-mentioned preparation scheme. Spectral detection results.
- mice 900 1-day-old Lingnan Huangkuai broilers; 150 weaned piglets;
- Test samples Compound 1, Compound 2, Compound 3, Compound 4, Compound 5, Compound 6, Compound 7, (Compound 8, prepared by the method provided in "Chemical World", 2005, 02, 94-96), L-aspartic acid, and copper sulfate pentahydrate.
- 900 1-day-old Lingnan Huangkuai large broilers were randomly divided into 18 groups with 50 chickens in each group.
- the control group was only supplemented with a physiologically recommended amount of copper sulfate of 5 mg/kg, and the other groups were not supplemented with any copper element.
- Compound 1-100 50 50 Compound 1 100 Compounds 1-50 50 50 Compound 1 50 Compound 1 50 Compound 1-35 50 50 Compound 1 35 Compounds 1-5 50 50 Compound 1 5 Compound 2-50 50 50 Compound 2 50 Compound 3-50 50 50 Compound 3 50 Compound 4-50 50 50 Compound 4 50 Compounds 5-50 50 50 Compound 5 50 Compounds 6-50 50 50 Compound 6 50 Compounds 7-50 50 50 Compound 7 50 Compounds 8-50 50 50 Compound 8 50 L-Aspartic Acid 50 50 L-Aspartic Acid 105
- the added amount of different growth promoters is calculated based on the copper ion in the compound, and the added amount of the L-aspartic acid group is the same mole as the L-aspartic acid contained in the use amount of the compound 1-50 group quality.
- the additive amount of different growth promoters is calculated according to the copper ion in the compound; the additive amount of the L-aspartic acid group is the same mole as the L-aspartic acid contained in the use amount of the compound 1-50 group quality.
- Lingnan Huangkuai broilers During the feeding test of Lingnan Huangkuai broilers, in the copper sulfate group of 150 mg/kg and 100 mg/kg of copper ions, in the second week of the experiment, Lingnan Huangkuai broilers had poisoning symptoms such as messy feathers and dry skin. A small number of dead chickens appeared before the end of the test, indicating that the long-term use of feed with a copper sulfate dosage of 100 mg/kg has toxic and side effects on broilers.
- the copper sulfate group with 50mg/kg copper ions had no clinically visible symptoms of poisoning, but the relative weight gain rate during the test period was 98.9%, which was close to that of the control group without administration, but the feed meat was 0.048 higher than the control group, and the feed remuneration was good. Not improved.
- Each test group of compound 1, compound 2, compound 3, compound 4, compound 5, compound 6 and compound 7 basically showed a good growth-promoting effect and the body surface characteristics of the test chickens were normal, and the relative weight gain rate could be increased by 4.9%- 19.6%, the feed remuneration decreased by 2.95%-6.34%, and the experimental effect of the experimental group with the addition amount of compound 1 was 50-100 mg/kg showed a dose effect.
- the high-dose copper sulfate pentahydrate group (250 mg/kg) had obvious growth-promoting effect.
- the average weight gain during the experiment was 12.66% higher than that of the non-administration control group, and the feed reward decreased by 7.8%.
- Compound 1, compound 2, compound 3, compound 4, compound 5, compound 6, compound 7 and compound 8 were used in this experiment.
- the first seven compounds all had the effect of promoting the growth of test pigs, but at the same dose
- Compound 1, compound 2 and compound 3 improved the feed reward of test pigs about twice as much as compound 4, and the dosage of compound 1, compound 2 and compound 3 was less than that of compound 4 under similar feed reward.
- the production performance of the test pigs of compound 8 at the dose was basically close to that of the control group.
- compound 1 showed a dose effect in improving the production performance of the test pigs.
- the dose was 50 mg/kg
- the growth-promoting effect and feed rate of the high-dose copper sulfate group were similar (Table 4). The results suggest that the compound of 50 mg/kg 1 It can be used to replace high-dose copper sulfate in pig breeding.
- mice The experimental fish used were herring, and the fingerlings of the year were provided by Dafeng Fish Breeding Farm, Huizhou City, Guangdong province. Healthy and lively herring species with consistent specifications were raised in large cages (4 ⁇ 2 ⁇ 1.5m 3 ) for 4 weeks before being used for formal breeding experiments. Each small cage is equipped with an inflation head, which is inflated 24 hours a day. Both the small cage and the temporary cage were placed in a pond of 3500 m 2 in the test site, the pond depth was about 1.5 m, and the pond water was fully aerated bottom water. During the experiment, 480 herrings that were starved for 1 day were randomly divided into 10 groups, each group had 4 replicates, and 12 fish were placed in each replicate. After weighing the whole, they were randomly placed into 28 cages and fed with different experimental feeds respectively. .
- Test feed The test feed was prepared according to the formula in Table 5, and different copper supplements (calculated as copper ions) were added to different test groups according to Table 6.
- the feed raw materials used were ultrafinely pulverized and then passed through the Jiangsu Muyang extruding unit to make a 3mm floating extruded feed.
- the mold temperature was 130°C, and 3% soybean oil was sprayed externally through an oil injection device, and sealed and stored in a cool place for later use.
- Raw material composition content(%) Raw material composition content(%) fish meal 9.0 soybean oil 3.0 casing powder 3.0 phospholipid rapeseed meal 9.0
- Test management The test adopts artificial food restriction feeding, and the feeding amount is adjusted once a week.
- the feeding level (according to the initial body weight) of each group is exactly the same, and the feeding is twice a day (7:30 and 15:00).
- the test lasts for 8 weeks. .
- the water quality was monitored regularly.
- the water temperature of the whole breeding process was 26.88 ⁇ 3.08°C, DO>5.0mg OL -1 , pH 7.8, ammonia nitrogen ⁇ 0.50mg NL -1 , nitrite nitrogen ⁇ 0.05mg NL -1 .
- Average weight gain (g) average final weight - average initial weight
- Feed to meat ratio food intake/fish body weight gain
- the growth-promoting test results of copper aspartate complexes on fish are shown in Table 6.
- the results show that the copper aspartate complex provided by the present invention can significantly increase the daily gain of the test fish and improve the ratio of feed to meat within the limited range of animal physiological requirements.
- the improvement of production performance has a better effect.
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Physiology (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Marine Sciences & Fisheries (AREA)
- Biomedical Technology (AREA)
- Insects & Arthropods (AREA)
- Botany (AREA)
- Mycology (AREA)
- Fodder In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
组别 | 动物数量 | 平均初重(g) | 生长促进剂 | 浓度(mg/kg)* |
对照组 | 50 | 50 | 五水硫酸铜 | 5 |
五水硫酸铜-150 | 50 | 50 | 五水硫酸铜 | 150 |
五水硫酸铜-100 | 50 | 50 | 五水硫酸铜 | 100 |
五水硫酸铜-50 | 50 | 50 | 五水硫酸铜 | 50 |
化合物1-300 | 50 | 50 | 化合物1 | 300 |
化合物1-200 | 50 | 50 | 化合物1 | 200 |
化合物1-100 | 50 | 50 | 化合物1 | 100 |
化合物1-50 | 50 | 50 | 化合物1 | 50 |
化合物1-35 | 50 | 50 | 化合物1 | 35 |
化合物1-5 | 50 | 50 | 化合物1 | 5 |
化合物2-50 | 50 | 50 | 化合物2 | 50 |
化合物3-50 | 50 | 50 | 化合物3 | 50 |
化合物4-50 | 50 | 50 | 化合物4 | 50 |
化合物5-50 | 50 | 50 | 化合物5 | 50 |
化合物6-50 | 50 | 50 | 化合物6 | 50 |
化合物7-50 | 50 | 50 | 化合物7 | 50 |
化合物8-50 | 50 | 50 | 化合物8 | 50 |
L-天冬氨酸 | 50 | 50 | L-天冬氨酸 | 105 |
组别 | 动物数量 | 平均初重(kg) | 生长促进剂 | 浓度(mg/kg)* |
不加促长剂对照组 | 10 | 8.36 | 五水硫酸铜 | 8 |
五水硫酸铜-250 | 10 | 8.31 | 五水硫酸铜 | 250 |
化合物1-150 | 10 | 8.42 | 化合物1 | 150 |
化合物1-100 | 10 | 8.38 | 化合物1 | 100 |
化合物1-50 | 10 | 8.25 | 化合物1 | 50 |
化合物1-35 | 10 | 8.31 | 化合物1 | 35 |
化合物1-8 | 10 | 8.44 | 化合物1 | 8 |
化合物2-50 | 10 | 8.35 | 化合物2 | 50 |
化合物3-50 | 10 | 8.32 | 化合物3 | 50 |
化合物4-50 | 10 | 8.40 | 化合物4 | 50 |
化合物5-50 | 10 | 8.51 | 化合物5 | 50 |
化合物6-50 | 10 | 8.37 | 化合物6 | 50 |
化合物7-50 | 10 | 8.44 | 化合物7 | 50 |
化合物8-50 | 10 | 8.29 | 化合物8 | 50 |
L-天冬氨酸 | 10 | 8.43 | L-天冬氨酸 | 104 |
原料组成 | 含量(%) | 原料组成 | 含量(%) |
鱼粉 | 9.0 | 豆油 | 3.0 |
肠衣粉 | 3.0 | 磷脂菜粕 | 9.0 |
豆粕 | 12.0 | 谷朊粉 | 4.0 |
菜粕 | 12.0 | 血球粉 | 2.0 |
味精蛋白 | 3.0 | Vc-磷酸酯 | 0.1 |
次粉 | 12.6 | 磷酸二氢钙 | 1.8 |
面粉 | 17.0 | 氯化胆碱 | 0.2 |
膨润土 | 0.70 | 多维 | 0.1 |
米糠 | 10.0 | 微矿预混剂 | 0.5 |
Claims (12)
- 一种化学结构为[(Cu(II))(Asp)(H 2O) m]·(H 2O) n的天冬氨酸铜配合物,其中,Asp为L-Asp或DL-Asp,m为0-10中的任意整数,n为0-10中的任意值。
- 根据权利要求1所述的天冬氨酸铜配合物,其特征在于,所述的m为2,n为0-0.62中的任意值。
- 权利要求1-3任一项所述的天冬氨酸铜配合物在制备动物饲料添加剂中的应用。
- 根据权利要求4所述的应用,其特征在于,所述的动物饲料添加剂为适用于各个生长阶段的家畜、家禽、水产动物或宠物的饲料添加剂。
- 根据权利要求4所述的应用,其特征在于,所述的天冬氨酸铜配合物在动物饲料中添加量以铜元素计为5mg/kg~300mg/kg。
- 根据权利要求6所述的应用,其特征在于,所述的天冬氨酸铜配合物为铜元素补充剂,以铜元素计,在动物饲料中添加量为5mg/kg-35mg/kg。
- 根据权利要求5所述的应用,其特征在于,所述的天冬氨酸铜配合物为促进动物生长促进剂。
- 根据权利要求8所述的应用,其特征在于,所述的天冬氨酸铜配合物在动物饲料中添加量以铜元素计为5mg/kg~250mg/kg,所述动物为各个生长阶段的猪、鸡或鸭。
- 一种饲用组合物,其特征在于,包含权利要求1-3任一项所述的天冬氨酸铜配合物中的至少一种以及药学、食品或饲料可接受的载体、赋形剂、稀释剂、溶媒中的至少一种。
- 根据权利要求10所述的饲用组合物,其特征在于,还包括附加的动物饲料添加剂。
- 根据权利要求10或11所述的饲用组合物,其特征在于,还包括饲料原料。
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2023011724A MX2023011724A (es) | 2021-04-07 | 2022-02-28 | Complejo de acido aspartico y cobre, y uso de este. |
KR1020237034800A KR20230156392A (ko) | 2021-04-07 | 2022-02-28 | 구리 아스파르테이트 착물 및 이의 응용 |
AU2022205117A AU2022205117A1 (en) | 2021-04-07 | 2022-02-28 | Aspartic acid copper complex, and use thereof |
JP2023558206A JP2024511428A (ja) | 2021-04-07 | 2022-02-28 | アスパラギン酸銅錯体及びその応用 |
PE2023002742A PE20240122A1 (es) | 2021-04-07 | 2022-02-28 | Complejo de acido aspartico y cobre, y uso de este |
CA3213900A CA3213900A1 (en) | 2021-04-07 | 2022-02-28 | Aspartic acid copper complex, and use thereof |
BR112023020065A BR112023020065A2 (pt) | 2021-04-07 | 2022-02-28 | Complexo de ácido aspártico e cobre e uso do mesmo |
IL307375A IL307375A (en) | 2021-04-07 | 2022-02-28 | Aspartic acid copper compound, and its use |
EP22734769.7A EP4295698A1 (en) | 2021-04-07 | 2022-02-28 | Aspartic acid copper complex, and use thereof |
CONC2023/0014258A CO2023014258A2 (es) | 2021-04-07 | 2023-10-24 | Complejo de ácido aspártico y cobre, y uso de este |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110372778.5 | 2021-04-07 | ||
CN202110372778.5A CN113170837A (zh) | 2021-04-07 | 2021-04-07 | 一种天冬氨酸铜配合物及其应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2022144044A1 true WO2022144044A1 (zh) | 2022-07-07 |
Family
ID=76923206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CN2022/078264 WO2022144044A1 (zh) | 2021-04-07 | 2022-02-28 | 一种天冬氨酸铜配合物及其应用 |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP4295698A1 (zh) |
JP (1) | JP2024511428A (zh) |
KR (1) | KR20230156392A (zh) |
CN (1) | CN113170837A (zh) |
AR (1) | AR125660A1 (zh) |
AU (1) | AU2022205117A1 (zh) |
BR (1) | BR112023020065A2 (zh) |
CA (1) | CA3213900A1 (zh) |
CL (1) | CL2023002961A1 (zh) |
CO (1) | CO2023014258A2 (zh) |
IL (1) | IL307375A (zh) |
MX (1) | MX2023011724A (zh) |
PE (1) | PE20240122A1 (zh) |
WO (1) | WO2022144044A1 (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113170837A (zh) * | 2021-04-07 | 2021-07-27 | 彭险峰 | 一种天冬氨酸铜配合物及其应用 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1484971A (zh) * | 2003-08-12 | 2004-03-31 | 石家庄市科星动物保健品有限公司 | 氨基酸螯合物预混合饲料 |
US20040077714A1 (en) * | 2002-10-16 | 2004-04-22 | Zinpro Corporation | Metal complexes of alpha amino dicarboxylic acids |
WO2010074602A1 (ru) * | 2008-12-25 | 2010-07-01 | Voronin Sergei Petrovich | Биодоступная форма микроэлементных добавок в кормовые смеси для животных и птиц |
WO2020159399A1 (ru) * | 2019-01-31 | 2020-08-06 | Акционерное Общество "Биоамид" | Способ получения комплексной микроэлементной добавки в корма на основе органических соединений железа, марганца, цинка, меди, кобальта |
EA201900072A2 (ru) * | 2019-01-31 | 2020-08-31 | Акционерное Общество "Биоамид" | Способ получения комплексной микроэлементной добавки в корма на основе органических соединений железа, марганца, цинка, меди, кобальта |
CN113170837A (zh) * | 2021-04-07 | 2021-07-27 | 彭险峰 | 一种天冬氨酸铜配合物及其应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1887902B (zh) * | 2006-07-28 | 2011-09-07 | 北京华美天意科技开发有限公司 | 氨基酸短肽螯合物及其制备方法 |
CN102578394A (zh) * | 2010-03-12 | 2012-07-18 | 广州英赛特生物技术有限公司 | 谷氨酸铜或其衍生物作为动物促生长饲料添加剂的应用 |
CN101756042B (zh) * | 2010-03-12 | 2012-07-04 | 广州英赛特生物技术有限公司 | 谷氨酸铜或其衍生物作为动物促生长饲料添加剂的应用 |
CN102599346A (zh) * | 2010-03-12 | 2012-07-25 | 广州英赛特生物技术有限公司 | 谷氨酸铜或其衍生物作为动物促生长饲料添加剂的应用 |
CN102599347A (zh) * | 2010-03-12 | 2012-07-25 | 广州英赛特生物技术有限公司 | 谷氨酸铜或其衍生物作为动物促生长饲料添加剂的应用 |
-
2021
- 2021-04-07 CN CN202110372778.5A patent/CN113170837A/zh active Pending
-
2022
- 2022-02-28 MX MX2023011724A patent/MX2023011724A/es unknown
- 2022-02-28 WO PCT/CN2022/078264 patent/WO2022144044A1/zh active Application Filing
- 2022-02-28 CA CA3213900A patent/CA3213900A1/en active Pending
- 2022-02-28 AU AU2022205117A patent/AU2022205117A1/en active Pending
- 2022-02-28 BR BR112023020065A patent/BR112023020065A2/pt active Search and Examination
- 2022-02-28 KR KR1020237034800A patent/KR20230156392A/ko unknown
- 2022-02-28 JP JP2023558206A patent/JP2024511428A/ja active Pending
- 2022-02-28 PE PE2023002742A patent/PE20240122A1/es unknown
- 2022-02-28 IL IL307375A patent/IL307375A/en unknown
- 2022-02-28 EP EP22734769.7A patent/EP4295698A1/en active Pending
- 2022-04-07 AR ARP220100869A patent/AR125660A1/es unknown
-
2023
- 2023-10-03 CL CL2023002961A patent/CL2023002961A1/es unknown
- 2023-10-24 CO CONC2023/0014258A patent/CO2023014258A2/es unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040077714A1 (en) * | 2002-10-16 | 2004-04-22 | Zinpro Corporation | Metal complexes of alpha amino dicarboxylic acids |
CN1484971A (zh) * | 2003-08-12 | 2004-03-31 | 石家庄市科星动物保健品有限公司 | 氨基酸螯合物预混合饲料 |
WO2010074602A1 (ru) * | 2008-12-25 | 2010-07-01 | Voronin Sergei Petrovich | Биодоступная форма микроэлементных добавок в кормовые смеси для животных и птиц |
WO2020159399A1 (ru) * | 2019-01-31 | 2020-08-06 | Акционерное Общество "Биоамид" | Способ получения комплексной микроэлементной добавки в корма на основе органических соединений железа, марганца, цинка, меди, кобальта |
EA201900072A2 (ru) * | 2019-01-31 | 2020-08-31 | Акционерное Общество "Биоамид" | Способ получения комплексной микроэлементной добавки в корма на основе органических соединений железа, марганца, цинка, меди, кобальта |
CN113170837A (zh) * | 2021-04-07 | 2021-07-27 | 彭险峰 | 一种天冬氨酸铜配合物及其应用 |
Non-Patent Citations (1)
Title |
---|
CHEMICAL WORLD, vol. 02, 2005, pages 94 - 96 |
Also Published As
Publication number | Publication date |
---|---|
AR125660A1 (es) | 2023-08-02 |
PE20240122A1 (es) | 2024-01-22 |
EP4295698A1 (en) | 2023-12-27 |
CL2023002961A1 (es) | 2024-01-26 |
CO2023014258A2 (es) | 2023-11-20 |
MX2023011724A (es) | 2023-10-12 |
BR112023020065A2 (pt) | 2023-11-14 |
JP2024511428A (ja) | 2024-03-13 |
KR20230156392A (ko) | 2023-11-14 |
AU2022205117A1 (en) | 2023-10-26 |
IL307375A (en) | 2023-11-01 |
CA3213900A1 (en) | 2022-07-07 |
CN113170837A (zh) | 2021-07-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPH05500755A (ja) | カルニチン補充のナマズ飼料 | |
ES2907015T3 (es) | Sal compuesta de N,N-dimetilglicina y un ácido orgánico y composición y uso de la misma | |
CN107573253B (zh) | N,n-二甲基甘氨酸有机酸共轭酸盐及其组合物和应用 | |
WO2022144044A1 (zh) | 一种天冬氨酸铜配合物及其应用 | |
RU2285399C1 (ru) | Способ повышения мясной продуктивности молодняка свиней на откорме | |
CN108029863B (zh) | 丁酰甘氨酸及其衍生物在制备动物饲料添加剂中的应用 | |
CN108218739B (zh) | 丁酰谷氨酸衍生物及其组合物和应用 | |
WO2020093187A1 (zh) | 天门冬氨酸衍生物在制备动物饲料添加剂中的应用 | |
CN110582207B (zh) | 一种谷氨酰胺衍生物在制备动物饲料添加剂中的应用 | |
CN111869791A (zh) | 半胱胺镁作为一种动物饲料添加剂的应用 | |
WO2020093188A1 (zh) | 天门冬氨酸脂肪酰基衍生物在制备动物饲料添加剂中的应用 | |
CN113768046B (zh) | 呋喃甲酸类化合物在制备动物饲料添加剂中的应用 | |
WO2022253361A1 (zh) | 呋喃甲酸类化合物在制备动物饲料添加剂中的应用 | |
AU2019432401B9 (en) | USE OF γ-QUATERNARY AMMONIUM BUTYRATE COMPOUND IN PREPARATION OF ANIMAL FEED ADDITIVE | |
RU2770763C1 (ru) | Пути применения дифенилпропенонового соединения в получении кормовой добавки для животных или корма для животных и кормовая композиция, содержащая указанное соединение | |
JP2024524755A (ja) | 動物用飼料添加物の調製におけるフランカルボン酸化合物の使用 | |
WO2019223630A1 (zh) | N-乙酰甘氨酰谷氨酰胺在动物饲料添加剂中的应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 22734769 Country of ref document: EP Kind code of ref document: A1 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2023558206 Country of ref document: JP Ref document number: 2022734769 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 3213900 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 307375 Country of ref document: IL Ref document number: 002742-2023 Country of ref document: PE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 18285264 Country of ref document: US |
|
WWE | Wipo information: entry into national phase |
Ref document number: MX/A/2023/011724 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2301006590 Country of ref document: TH |
|
ENP | Entry into the national phase |
Ref document number: 2022734769 Country of ref document: EP Effective date: 20230921 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 804429 Country of ref document: NZ Ref document number: AU2022205117 Country of ref document: AU Ref document number: 2022205117 Country of ref document: AU |
|
REG | Reference to national code |
Ref country code: BR Ref legal event code: B01A Ref document number: 112023020065 Country of ref document: BR |
|
ENP | Entry into the national phase |
Ref document number: 20237034800 Country of ref document: KR Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020237034800 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2023126470 Country of ref document: RU |
|
ENP | Entry into the national phase |
Ref document number: 2022205117 Country of ref document: AU Date of ref document: 20220228 Kind code of ref document: A |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 112023020065 Country of ref document: BR Kind code of ref document: A2 Effective date: 20231002 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 523450696 Country of ref document: SA |