WO2022131880A3 - 2종 이상의 서로 다른 조성물을 함유한 제제학적으로 안정한 연질캡슐제 - Google Patents

2종 이상의 서로 다른 조성물을 함유한 제제학적으로 안정한 연질캡슐제 Download PDF

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Publication number
WO2022131880A3
WO2022131880A3 PCT/KR2021/019367 KR2021019367W WO2022131880A3 WO 2022131880 A3 WO2022131880 A3 WO 2022131880A3 KR 2021019367 W KR2021019367 W KR 2021019367W WO 2022131880 A3 WO2022131880 A3 WO 2022131880A3
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WO
WIPO (PCT)
Prior art keywords
different compositions
soft capsule
pharmaceutically stable
stable soft
pharmaceutically
Prior art date
Application number
PCT/KR2021/019367
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English (en)
French (fr)
Other versions
WO2022131880A2 (ko
Inventor
박명훈
윤소희
홍수봉
최지혜
Original Assignee
코스맥스파마 주식회사
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Publication date
Application filed by 코스맥스파마 주식회사 filed Critical 코스맥스파마 주식회사
Priority to AU2021402764A priority Critical patent/AU2021402764A1/en
Priority to JP2023537548A priority patent/JP2024503248A/ja
Publication of WO2022131880A2 publication Critical patent/WO2022131880A2/ko
Publication of WO2022131880A3 publication Critical patent/WO2022131880A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

2종 이상의 서로 다른 조성물을 함유한 제제학적으로 안정한 연질캡슐제에 관한 것으로, 각각의 단일제를 복합제형으로 제제화할 수 있으며, 2종 이상의 서로 다른 조성물 간의 반응을 최소화하여 안정성이 향상된 제제를 제공할 수 있다.
PCT/KR2021/019367 2020-12-18 2021-12-20 2종 이상의 서로 다른 조성물을 함유한 제제학적으로 안정한 연질캡슐제 WO2022131880A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2021402764A AU2021402764A1 (en) 2020-12-18 2021-12-20 Pharmaceutically stable soft capsule comprising two or more different compositions
JP2023537548A JP2024503248A (ja) 2020-12-18 2021-12-20 ２種以上の異なる組成物を含有する薬剤学的に安定な軟質カプセル剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2020-0178666 2020-12-18
KR1020200178666A KR102607454B1 (ko) 2020-12-18 2020-12-18 2종 이상의 서로 다른 조성물을 함유한 제제학적으로 안정한 연질캡슐제

Publications (2)

Publication Number Publication Date
WO2022131880A2 WO2022131880A2 (ko) 2022-06-23
WO2022131880A3 true WO2022131880A3 (ko) 2023-03-30

Family

ID=82060136

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2021/019367 WO2022131880A2 (ko) 2020-12-18 2021-12-20 2종 이상의 서로 다른 조성물을 함유한 제제학적으로 안정한 연질캡슐제

Country Status (4)

Country Link
JP (1) JP2024503248A (ko)
KR (2) KR102607454B1 (ko)
AU (1) AU2021402764A1 (ko)
WO (1) WO2022131880A2 (ko)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150033405A (ko) * 2013-09-24 2015-04-01 한국화학연구원 고지혈증치료제 및 오메가-3 지방산을 함유하는 복합제제
JP2015512945A (ja) * 2012-04-13 2015-04-30 バナー ファーマキャップス，インコーポレイティド 錠剤と液体または半固体の充填剤とを含む軟質弾性カプセル、ならびにそれらの製造方法
KR20190077096A (ko) * 2016-12-23 2019-07-02 알.피.쉐러 테크놀러지즈 엘엘씨 다중 충전/챔버 소프트겔 다이
KR102050069B1 (ko) * 2019-03-29 2019-11-28 (주)알피바이오 안정성이 향상된 연질캡슐 제제용 충진조성물 및 이를 포함하는 연질캡슐 제제
KR102140014B1 (ko) * 2019-03-25 2020-09-02 유엠에스엔지니어링 주식회사 연질캡슐 제조 장치
KR102164913B1 (ko) * 2020-06-10 2020-10-13 정수영 이종(異種)의 약액으로 이루어진 캡슐성형을 위한 연질 캡슐 성형장치
KR20200134403A (ko) * 2019-05-22 2020-12-02 정수영 약제 성형기

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015512945A (ja) * 2012-04-13 2015-04-30 バナー ファーマキャップス，インコーポレイティド 錠剤と液体または半固体の充填剤とを含む軟質弾性カプセル、ならびにそれらの製造方法
KR20150033405A (ko) * 2013-09-24 2015-04-01 한국화학연구원 고지혈증치료제 및 오메가-3 지방산을 함유하는 복합제제
KR20190077096A (ko) * 2016-12-23 2019-07-02 알.피.쉐러 테크놀러지즈 엘엘씨 다중 충전/챔버 소프트겔 다이
KR102140014B1 (ko) * 2019-03-25 2020-09-02 유엠에스엔지니어링 주식회사 연질캡슐 제조 장치
KR102050069B1 (ko) * 2019-03-29 2019-11-28 (주)알피바이오 안정성이 향상된 연질캡슐 제제용 충진조성물 및 이를 포함하는 연질캡슐 제제
KR20200134403A (ko) * 2019-05-22 2020-12-02 정수영 약제 성형기
KR102164913B1 (ko) * 2020-06-10 2020-10-13 정수영 이종(異種)의 약액으로 이루어진 캡슐성형을 위한 연질 캡슐 성형장치

Also Published As

Publication number Publication date
KR20220088036A (ko) 2022-06-27
JP2024503248A (ja) 2024-01-25
KR102607454B1 (ko) 2023-11-29
KR20230169000A (ko) 2023-12-15
AU2021402764A1 (en) 2023-08-03
WO2022131880A2 (ko) 2022-06-23

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