WO2022124138A1 - Procédé d'embellissement destiné à favoriser la génération de collagène cutané - Google Patents

Procédé d'embellissement destiné à favoriser la génération de collagène cutané Download PDF

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Publication number
WO2022124138A1
WO2022124138A1 PCT/JP2021/043861 JP2021043861W WO2022124138A1 WO 2022124138 A1 WO2022124138 A1 WO 2022124138A1 JP 2021043861 W JP2021043861 W JP 2021043861W WO 2022124138 A1 WO2022124138 A1 WO 2022124138A1
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Prior art keywords
skin
electrode
current
beauty
sheet
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PCT/JP2021/043861
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English (en)
Japanese (ja)
Inventor
デイヴィッド ディアズ オーディナリオ
和之 宮沢
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株式会社 資生堂
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Priority to JP2022568205A priority Critical patent/JPWO2022124138A1/ja
Publication of WO2022124138A1 publication Critical patent/WO2022124138A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation

Definitions

  • the present invention relates to a cosmetological method for promoting collagen production in the skin.
  • Patent Document 1 is an ultrasonic beauty treatment apparatus having an electric function in the main body of the apparatus for generating an ultrasonic excitation mode that changes between the maximum output and the minimum output, and the DC output voltage from a DC power supply is variable. Disclose a device configured to allow it.
  • Patent Document 2 is a treatment device including a high-frequency signal generation circuit that continuously and repeatedly changes the oscillation output of a high-frequency signal between a maximum value and a minimum value with the passage of time to give a high-frequency signal to an ultrasonic vibrator. To disclose.
  • Patent Document 3 has a magnetic field generating portion that generates a magnetic field that irradiates the fibroblasts and collagen tissue inside the epidermis on the outside of the epidermis, and irradiates the fibroblasts and collagen tissue inside the epidermis with the magnetic field through the epidermis. By doing so, the collagen tissue inside the epidermis is contracted, and a beauty device having an anti-wrinkle effect is disclosed.
  • the present inventor has surprisingly found that application of a pulsed current to a skin cell promotes the collagen-producing ability of the cell. Therefore, the present invention provides a cosmetological method for promoting collagen production in the skin.
  • the present invention includes the following inventions.
  • a cosmetic method for promoting collagen production in the skin which comprises applying a pulse current to the target skin.
  • the beauty method of (1) wherein the pulse current has a frequency in the range of 200 Hz to 5000 Hz.
  • the beauty method of (2) wherein the current value of the pulse current is in the range of 100 to 1000 ⁇ A.
  • the conductive material is between a flexible base layer, an adhesive layer attached to one side surface of the base layer and having adhesiveness to the user's skin, and the base layer and the adhesive layer.
  • the beauty method according to (4) wherein the conductive layer is composed of a conductive layer arranged in the above, and the conductive layer is electrically coupled to an electrode to which a current is applied from a current generating portion.
  • the drug layer is further arranged between the conductive layer and the adhesive layer or on the surface of the adhesive layer.
  • the beauty method according to any one of (1) to (9) for improving wrinkles on the skin (11) The beauty method according to any one of (1) to (10), wherein the step of applying the pulse current to the target skin is performed for 1 to 120 minutes. (12)
  • the conductive material has first and second sheet-shaped electrodes that are independent of each other, and each of the first and second sheet-shaped electrodes is connected to a current generating portion through a conductive cable.
  • the conductive material includes one sheet-shaped electrode including a first electrode portion, a second electrode portion, and an insulating portion provided between the first and second electrode portions.
  • the single sheet-shaped electrode has first and second terminals electrically connected to each of the first electrode portion and the second electrode portion, and the first and second terminals are provided.
  • the beauty method according to any one of (5) to (11), wherein the terminal is connected to the current generating portion.
  • the beauty method is carried out by using a beauty device, and the beauty device is It is equipped with a device unit and a sheet-shaped skin electrode that contacts the user's skin and gives electrical stimulation.
  • the device unit is a current generation unit for generating a pulse current, a control unit for controlling the current generation unit, and a skin electrode connection electrode for electrically connecting the current generation unit and the skin electrode.
  • the skin electrode is made of a conductive material that applies the current from the current generating part to the skin via the sheet connection electrode.
  • the hollow housing has a flat plate-shaped bottom wall, and the sheet connecting electrode and the ground electrode are arranged on the outer surface of the bottom wall.
  • Example 1 of an apparatus applied to the target skin via a conductive material Example 2 of an apparatus applied to the target skin via a conductive material.
  • It is a perspective view which shows the state at the time of wearing the beauty apparatus by a preferable embodiment of this invention. It is a side view of the device body of a beauty device. It is a bottom view of the mounting body of FIG. It is a schematic diagram of the inside of a mounting body which shows the closed part of a housing opened. It is sectional drawing of the mounting body along the arrow line-of-sight line VV of FIG. It is a schematic diagram which shows an example of the laminated structure of a sheet electrode. It is a schematic diagram which shows another example of the laminated structure of a sheet electrode.
  • FIG. 1 It is a schematic diagram which shows still another example of the laminated structure of a sheet electrode. Similar to FIG. 1, which shows a state in which the first electrode, which is the electrode for connecting the sheet, is brought into contact with the second portion 50b of the sheet electrode 50, and the second electrode, which is the electrode for skin, is brought into contact with the skin of the user. It is a perspective view. It is a chart which shows an example of the pulse wave generated by the pulse wave generation part. It is a perspective view which shows the state at the time of wearing the beauty apparatus by another preferable embodiment of this invention. It is a figure which shows the collagen amount (ng / cell) in Example 1. FIG. It is a figure which shows the change (au) of the water content of the skin in Example 2. FIG.
  • FIG. shows the change of the wrinkle in Example 2.
  • FIG. The figure below is an actual photograph of the skin taken with an ANTERA 3D camera, and the figure above is an image of the surface morphology of the skin portion corresponding to the figure below. It is a figure which shows the change of the depression index (Indentation Index) in Example 3.
  • FIG. Shows the effect of reducing wrinkles on facial facial devices from other companies on the market. The comparison test result between the apparatus of this invention and the product of another company is shown.
  • the present invention relates to a method of applying a pulse wave having a predetermined frequency to the skin.
  • a pulse wave having a predetermined frequency By applying the cosmetological method of the present invention, it becomes possible to produce collagen in the skin, moisturize the skin, and improve wrinkles.
  • collagen production of the skin is promoted, moisturized, and wrinkles are improved, the skin is effective for moisturizing, maintaining elasticity and elasticity.
  • a cosmetic method comprising a step of applying an electrical stimulus to the skin by a pulse wave having a frequency in the range of 100 to 5000 Hz, more preferably 200 to 5000 Hz, still more preferably 500 to 2000 Hz. ..
  • This cosmetological method may be performed by using a cosmetological device designed to apply a pulsed current to the skin.
  • the method of the present invention promotes the production of skin collagen.
  • the measurement of the ability to produce skin collagen may be performed by a well-known method and is not particularly limited.
  • the amount of collagen in fibroblasts can be measured using, for example, a commercially available collagen measurement kit.
  • it can be measured by utilizing the fact that 3,4-DHPAA selectively binds to a peptide having glycine at the N-terminal and emits fluorescence, as in the collagen quantification kit of Cosmo Bio Co., Ltd. described in Examples. ..
  • Collagen constituting the skin includes type I, type III, type IV, type V, type XII, type XIV and the like, and is not particularly limited in the present invention. good.
  • the beauty method of the present invention is applied, for example, 1 to 480 minutes, 1 to 240 minutes, 1 to 180 minutes, 1 to 120 minutes, 20 to 180 minutes, 20 to 120 minutes, 60 to 120 minutes, and fibroblasts.
  • the amount of collagen in skin cells such as cells is, for example, 1.1 times, 1.2 times, 1.3 times, 1.4 times, 1.5 times, 2.0 times, as compared with the case where nothing is applied.
  • the effect of increasing by 3.0 times, 6.0 times, or more is achieved.
  • the beauty method of the present invention can be applied for a long time, it is easy to apply a period longer than the above time. Further, such electrical stimulation may be performed a plurality of times.
  • the collagen production promoting effect of the present invention is achieved by applying a pulse wave to the skin at a constant frequency.
  • the pulse wave is 100 Hz to 5000 Hz, preferably 200 Hz to 5000 Hz, and more preferably 500 Hz to 2000 Hz.
  • the microcurrent generated by commercially available cosmetic devices and devices for wounds is about 0.1 Hz to 10 Hz, but the inventors of the present application apply skin collagen by applying a specific frequency higher than these. Was found to promote the production of.
  • facial equipment, massage equipment, and the like include those using electromagnetic waves having a frequency of about 0.3 to 300 MHz such as RF waves, and those using ultrasonic waves having a frequency of about 1 MHz to 7 MHz. Compared with these frequencies, the frequency adopted by the beauty method of the present invention is extremely low.
  • the current used to generate the pulse wave for example, the alternating current can be arbitrarily selected from 100 ⁇ A to 1000 ⁇ A, 150 ⁇ A to 1000 ⁇ A, 200 ⁇ A to 500 ⁇ A, and the like. It is preferably 200 ⁇ A to 500 ⁇ A. Since the current value in such a range is equivalent to the current value in human skin, there is little adverse effect on the skin.
  • the voltage can be arbitrarily selected from 1.0 V to 10.0 V, etc., 5.0 V to 10.0 V, etc., 1.0 V to 5.0 V, etc., within a range that does not adversely affect the skin.
  • the pulse wave and voltage waveform can be arbitrarily set such as a pulse wave, a square wave, a sine wave, a triangular wave, and a sawtooth wave.
  • the pulse wave applied to the skin is 1 to 480 minutes, 1 to 240 minutes, 1 to 120 minutes, 5 to 120 minutes, 20 to 180 minutes, 20 to 120 minutes, 60 to 120 minutes, 20 to 60 minutes. It can be arbitrarily selected within a range that does not adversely affect the skin, such as minutes, 20 to 40 minutes. It is preferably 1 to 120 minutes.
  • the pulse wave of the present invention to the skin for the above time, collagen production in the skin is promoted, moisturization is promoted, and wrinkles are improved.
  • the stimulus for the above time can be applied a plurality of times, such as twice, three times, four times, etc., or the stimulus for a time longer than the above time can be applied.
  • the frequency is daily, 2 days, 3 days, 4 days, 5 days, 6 days, 7 days, once every 1, 2, 3, 4 weeks, etc., continuously or intermittently, regularly or irregularly. It may be done in a targeted manner.
  • the cosmetological method of the present invention has the effect of promoting moisturizing of the skin.
  • the moisturizing promoting effect can be measured, for example, the amount of water in the skin, the amount of transepidermal water loss (TEWL), or the like using an arbitrary skin water content checker such as a corneometer.
  • TEWL transepidermal water loss
  • the pulse wave specified in the present invention is subjected to 1 to 480 minutes, 1 to 240 minutes, 1 to 120 minutes, 20 to 120 minutes, 60 to 120 minutes, 20 to 60 minutes, 20 to 40 minutes.
  • the beauty method of the present invention has a wrinkle improving effect.
  • the wrinkle improvement effect is obtained by visual inspection, judgment by a trained measurer, or image analysis, for example, image analysis of a photographic drawing taken by an Intera 3D camera (Gaderius) specifically shown in the embodiment of the present application. ) Can be measured.
  • the beauty method of the present invention is applied for 1 to 480 minutes, 1 to 240 minutes, 1 to 120 minutes, 20 to 120 minutes, 60 to 120 minutes, 20 to 60 minutes, 20 to 40 minutes, 2 hours after application, Wrinkle improvement effect of 5 hours, 7 hours, 12 hours, 24 hours, 36 hours, 48 hours, 60 hours, 72 hours or more can be expected.
  • the beauty method of the present invention is applied for 20 minutes and repeated once, or twice, three times or more at specific time intervals such as 6 hours, 12 hours, 24 hours and 48 hours. Therefore, for example, according to the dent index by image analysis using an Antera 3D camera, a wrinkle improving effect such as a reduction of 5.0, 6.0, 7.0, 8.0, 9.0 or more can be achieved. Further, since the beauty method of the present invention can be applied for a long time, further wrinkle improving effect is expected.
  • the subject to which the method of the present invention is applied is a subject to which collagen deficiency, water content deficiency, and wrinkles are objectively or subjectively recognized, but it is desired to prevent collagen deficiency, water content deficiency, and wrinkles. It may be the desired object.
  • the subject may be a subject judged to be deficient in collagen or water content or deeply wrinkled, or may be a subject to be concerned about, for example, dry skin, wrinkles, swelling, or decreased elasticity.
  • the amount of collagen, the amount of water, wrinkles, elasticity, elasticity and the like can be determined by using a known index such as visual judgment, subjective or objective evaluation, a cute meter value, or the above-mentioned method.
  • the collagen production promoting effect, moisturizing promoting effect, and wrinkle improving effect of the present invention can be measured not only by the above-mentioned methods but also by any method such as in vivo, in vitro, ex vivo, in situ.
  • the pulsed current can be applied to the skin of interest, for example via a conductive material.
  • the conductive material has first and second sheet-like electrodes that are independent of each other, and each of the first and second sheet-like electrodes is connected to a current generating portion through a conductive cable.
  • a pulsed current can be applied to the skin.
  • FIG. 1 the conductive material has first and second sheet-shaped electrodes 72a and 72b.
  • the first and second sheet-shaped electrodes 72a and 72b are independent of each other and can be attached to a desired portion of the skin S by the user.
  • the first and second sheet-shaped electrodes 72a and 72b are electrically connected to the current generating unit 70 by the cable 76.
  • FIG. 1 the example shown in FIG.
  • the cable 76 has a first and second branched cables 76a and 76b that are bifurcated.
  • the first and second branch cables 76a and 76b are connected to the first and second sheet-shaped electrodes 72a and 72b, respectively.
  • the cable 76 has a common pin jack or pin plug 76c at the other end for connecting to the current generating unit 70.
  • the conductive material is a single sheet-shaped electrode including a first electrode portion, a second electrode portion, and an insulating portion provided between the first and second electrode portions.
  • the one sheet-shaped electrode has first and second terminals electrically connected to each of the first electrode portion and the second electrode portion, and the first and second terminals are provided.
  • the terminal 2 can be connected to the current generator and the pulsed current can be applied to the skin.
  • FIG. 2 the conductive material has a single sheet-like electrode 82.
  • the sheet-shaped electrode 82 includes a first electrode portion 82a and a second electrode portion 82b, and an insulating portion 82c is provided between them.
  • the first and second electrode portions 82a and 82b and the insulating portion 82c are formed as a single sheet-like member.
  • the sheet-shaped electrode 82 has first and second electrode-side terminals 84a and 84b connected to the first and second electrode portions 82a and 82b.
  • the current generating unit 80 includes first and second power supply side terminals (not shown) that can be hooked or snapped to and separated from the first and second electrode side terminals 84a and 84b. By connecting the first and second electrode side terminals 84a and 84b to the first and second electrode side terminals, the sheet-shaped electrode 82 is connected to the current generation unit 80 without using a cable. At this time, the current generating unit 80 is attached to the sheet-shaped electrode 82.
  • the material of the conductive material is arbitrary, such as a conductive polymer having flexibility so as to be able to follow the unevenness of the skin, carbon black, resin, a dielectric elastomer actuator (DEA), an IPMC actuator, a PVC gel, and the like. Further, it may be thin so that it can be attached to the user's skin and transparent so that the wearing is not conspicuous, or it may be an embodiment matching the color of the user's skin.
  • the conductive material may be reusable or disposable, and a make-up or sunscreen may be applied over it.
  • the conductive material itself may have adhesiveness, and an adhesive layer for attaching the pulse wave having the frequency of the present invention to the skin of the user may be provided to the extent that the pulse wave can be applied to the skin. Further, the attachment of the conductive material to the skin may be achieved by providing an adhesive layer on the device portion or by providing the device with a mounting portion such as a belt, or may be achieved by the adhesiveness of the sheet electrode. A chemical layer may be arranged between the conductive layer and the adhesive layer. Alternatively, in addition to the conductive layer and the adhesive layer 56, a microneedle layer having microneedles made of hyaluronic acid or the like can be included. The microneedle layer can be provided on the adhesive layer on the opposite side of the conductive layer, that is, on the surface in contact with the user's skin.
  • the adhesive layer used for the electrode may be any material as long as it has a holding force when it adheres to the skin and does not cause pain when peeled off, and is applied, impregnated, adhered, or cast on one surface of the support material. It is provided by means such as.
  • Preferred examples of the adhesive component include various water-soluble polymers, oil-soluble polymers, and gel agents obtained by partially modifying these by means such as cross-linking.
  • the type of cross-linking agent, compounding agent, and compounding condition can be selected from known methods.
  • water-soluble polymers examples include polyacrylic acid, polyacrylic acid salt, polymethacrylic acid, polymethacrylate, polyvinyl alcohol, polyvinylpyrrolidone, polyacrylamide, polyacrylamide salt, polymethacrylamide, polymethacrylate salt, and methacryloyl.
  • oil-soluble polymer examples include a pressure-sensitive adhesive composed of a vinyl acetate / crotonic acid copolymer, a vinyl propionate / crotonic acid copolymer, a vinyl acetate resin, a trimethylsiloxysilicate polymer, a silicon resin or an acrylic polymer.
  • Rubber-based pressure-sensitive adhesives such as styrene-isoprene-styrene block copolymer, styrene-butadiene-styrene block copolymer, polyisoprene, poloisobutylene, and polybutadiene, silicone-based pressure-sensitive adhesives such as silicone rubber, dimethylsiloxane base, and diphenylsiloxane base.
  • Vinyl ether-based pressure-sensitive adhesives such as polyvinyl methyl ether, polyvinyl ethyl ether, polyvinyl isobutyl ether, vinyl ester-based pressure-sensitive adhesives such as vinyl acetate-ethylene copolymer, carboxylic acid components such as dimethyl terephthalate, dimethyl isophthalate, and dimethyl phthalate, and ethylene.
  • Polyester-based pressure-sensitive adhesive composed of polyhydric alcohol components such as glycol, various rubber-based polymers, acrylic-modified silicon resin, acrylic-modified silicon resin, epoxy resin, polyacrylonitrile, or co-polymerization of these polymerizable monomer raw materials with other polymerizable monomers. Examples include polymers.
  • the material for forming the microneedles that can be applied to the adhesive layer may be any material that exhibits a certain degree of hardness so as to pierce the skin and cause irritation, and the material itself is not particularly limited. However, since it is applied to the skin for a long time, it needs to be a biocompatible material, and is preferably formed of a material that can be dissolved or swollen in the living body. Examples of such a material include polysaccharides such as hyaluronic acid, chitosan, maltose, arginate, amylose and agarose, celluloses such as carboxymethyl cellulose and hydroxypropyl cellulose, starch and the like, which are formed by each material alone.
  • a particularly preferred material is hyaluronic acid.
  • it may be formed of a resin that does not dissolve or swell in the living body and does not affect the living body.
  • a resin that does not dissolve or swell in the living body and does not affect the living body.
  • the drug layer may be arranged between the conductive layer and the adhesive layer or on the surface of the adhesive layer, or the adhesive layer or the microneedle itself may contain the drug.
  • the drug is, for example, a water-soluble drug and a component of cosmetics conventionally used as a transdermal absorption preparation, for example, ascorbyl palmitate, kodiic acid, lucinol, tranexamic acid, potassium 4-methoxysalicylate, oily licorice extract, vitamin.
  • Whitening ingredients such as A derivatives; Anti-wrinkle ingredients such as retinol, retinoic acid, retinol acetate, retinol palmitate; Blood circulation promoting ingredients such as tocopherol acetate, capsine, and vanillylamide norylate; Diet ingredients such as raspberry ketone, evening primrose extract, and seaweed extract; Antibacterial components such as isopropylmethylphenol, photosensitizer, and zinc oxide; may be medicinal components such as vitamins such as vitamin D2, vitamin D3, and vitamin K.
  • One aspect of the present invention relates to a beauty device. Since the beauty device of the present invention, preferably a wearable beauty device, can be used hands-free, it can be used in various scenes such as wearing while working. Moreover, since the beauty device of the present invention is small and light, it is easy to carry.
  • the beauty device 100 includes a device main body 10 and a sheet electrode 50.
  • the sheet electrode 50 forming the sheet portion is detachably attached to the surface of the user's skin S, and the device main body 10 as the device portion comes into contact with both the user's skin S and the sheet electrode 50. It is designed to be arranged and used like this. That is, the beauty device 100 constitutes a beauty device used by being attached to the surface of the human body, particularly the skin S.
  • the apparatus main body 10 includes a housing main body portion 12 and a lid closing portion 14 that form a hollow housing.
  • the lid closing portion 14 is detachably attached to the housing main body portion 12.
  • the housing main body portion 12 is a bottomed hollow member having one end opened and the other end closed by a bottom wall 12a.
  • both the housing main body portion 12 and the lid closing portion 14 are cylindrical, but in another preferred embodiment, the housing main body portion 12 has a disk-shaped bottom wall and a lid closing portion as shown in FIG. 14 may constitute a housing with, for example, a dome-shaped closure coupled along the outer peripheral edge of the bottom wall.
  • the shape of the closed lid is not particularly limited and can be arbitrarily changed depending on the mounting site and form.
  • a circuit board 20 constituting a pulse wave generation unit for generating a pulse wave and a control unit for controlling the pulse wave generation unit is arranged.
  • the control unit controls the frequency, waveform, amplitude, etc. of the pulse wave of the pulse wave generation unit.
  • a battery 28 is further housed as a power source for supplying electric power to the pulse wave generation unit and the control unit.
  • the battery 28 can be a rechargeable rechargeable battery.
  • the device main body 10 also has a switch 22 for turning on / off the device main body 10, particularly the pulse wave generation unit on the circuit board 20.
  • a part of the switch 22 protrudes from the side surface of the housing main body portion 12 or the lid closing portion 14, and is pushed in in the radial direction to perform an on / off operation.
  • the switch 22 may be provided on the upper part of the dome-shaped closing portion 14 and the switch may be pushed downward to perform an on / off operation.
  • the apparatus main body 10 can include terminals 24 and 26 for connecting a charger (not shown) for charging the battery 28.
  • the terminals 24 and 26 are arranged so that the cord of the charger (not shown) can be connected from the side surface of the housing main body portion 12 or the lid closing portion 14.
  • the terminals 24 and 26 are separate types in which the positive pole and the negative pole are separated, but may be a coaxial type terminal having a positive pole and a negative pole.
  • the charging terminal may be a terminal for connecting a Type-A or Type-C USB cable, a Lightning (registered trademark) cable, or the like.
  • the circuit board 20 can also include a wireless communication port (not shown) capable of wireless communication with an external operating device.
  • the control unit can control the frequency and voltage of the pulse wave generated by the transmitter based on the signal from the operating device.
  • the operating device can be formed by a dedicated wireless operating device (not shown).
  • the operating device can be wirelessly connected to the wireless communication port by analog or digital communication of a specific frequency.
  • the operating device may be a commercially available handheld device such as a smartphone or tablet.
  • the operation application can be installed on the handheld device, and the operation device can be wirelessly connected to the wireless communication port via WIFI or Bluetooth (registered trademark).
  • a data receiving unit is provided instead of the switch 22, and the control unit may be remotely operated wirelessly by, for example, an operating device that uses data stored in a mobile phone, cloud, or the like. ..
  • the first and second electrodes 16 and 18 are arranged on the outer side of the housing of the bottom wall 12a of the housing main body portion 12.
  • the first and second output terminals 30 and 32 connected to the first and second electrodes 16 and 18 are provided on the inner side of the housing of the bottom wall 12a.
  • the circular first electrode 16 is a sheet connecting electrode for contacting the sheet electrode 50 and electrically connecting the pulse wave generating portion and the sheet electrode 50.
  • a substantially semicircular second electrode 18 larger than the electrode 16 serves as a skin electrode for contacting the surface of the user's skin S and electrically connecting the pulse wave generating portion and the skin S. ing.
  • the shapes of the first and second electrodes are arbitrary as long as the desired pulse wave can reach the skin S.
  • the sheet electrode 50 is made of a conductive material that applies a pulse wave from a pulse wave generating portion to the skin S via a first electrode 16 which is a sheet connecting electrode.
  • the material of the sheet electrode 50 is arbitrary, such as a conductive polymer having flexibility so as to be able to follow the unevenness of the skin, carbon black, resin, a dielectric elastomer actuator (DEA), an IPMC actuator, a PVC gel, and the like.
  • a first portion 50a which is a main part to be attached to the surface of the user's skin S and a pulse wave is applied to the skin S, and a second portion, which is a protruding portion extending outward from the first portion 50a. It has a portion 50b of.
  • the first portion 50a can have an area sufficient to effectively and effectively promote collagen production for the skin S in the desired region when the pulse wave is applied to the skin S of the user.
  • the sheet electrode 50 can take any shape. As shown in FIG. 1, the first portion 50a may have a circular shape, or may match the shape of a desired sticking portion such as a cheek.
  • the shape of the second portion 50b is also arbitrary as long as it has a sufficient length so that the apparatus main body 10 can be arranged apart from the first portion 50a.
  • the sheet electrode 50 may be thin so that it can be attached to the user's skin, and may be transparent so that the wearing is not conspicuous, or may be an embodiment that matches the color of the user's skin.
  • the sheet electrode 50 may be used repeatedly or may be disposable, and it may be possible to apply make-up or a sunscreen agent on the sheet electrode.
  • the sheet electrode 50 itself may have adhesiveness, and the sheet electrode 50 may be adhered to the user's skin S to the extent that the pulse wave having the frequency of the present invention can be applied to the skin.
  • a layer may be provided.
  • the attachment of the apparatus main body 10s to the skin may be achieved by providing an adhesive layer on the device portion or by providing the device with a mounting portion such as a belt, or may be achieved by the adhesiveness of the sheet electrode.
  • the sheet electrode 50 can have a laminated structure composed of three layers as an example.
  • the sheet electrode 50 can have, for example, a flexible and stretchable stretchable layer 52, a conductive layer 54, and an adhesive layer 56.
  • the elastic layer 52 can be formed from, for example, a non-woven fabric.
  • the conductive layer 54 can be formed of, for example, a conductive polymer, carbon black, resin, a dielectric elastomer actuator (DEA), an IPMC actuator, a PVC gel, or the like.
  • the sheet electrode 50 may have four layers. As shown in FIG. 9, the sheet electrode 50 can include a drug layer 58 arranged between the conductive layer 54 and the adhesive layer 56 in addition to the elastic layer 52, the conductive layer 54 and the adhesive layer 56. Alternatively, the sheet electrode 50 can include a microneedle layer 60 having microneedles made of hyaluronic acid or the like, in addition to the elastic layer 52, the conductive layer 54 and the adhesive layer 56. The microneedle layer 60 can be provided on the opposite side of the conductive layer 64 in the adhesive layer 56, that is, on the surface in contact with the user's skin when the sheet electrode 50 is attached to the user's skin.
  • the sheet electrode 50 is attached to a desired position on the user's skin S.
  • the orientation of the second portion 50b is determined so that the apparatus main body 10 can be arranged at an appropriate position on the surface of the user's skin S.
  • the bottom wall 12a of the housing main body 12 is made to face the user's skin S, and as shown in FIG. 11, the first electrode 16 is brought into contact with the second portion 50b of the sheet electrode 50, and the second electrode is used.
  • the device body 10 is attached to the surface of the user's skin S by arranging the 18 so as to be in contact with the user's skin S.
  • the switch 22 is turned on to apply a pulse wave to the user's skin S.
  • the pulse wave it may be a pulse-shaped pulse wave as shown in FIG. 120.
  • the pulse wave waveform shown in FIG. 12 is an example, and the present invention is not limited to this, and a square wave, a sine wave, a triangular wave, a sawtooth wave, or the like can be arbitrarily set.
  • the beauty device 100 when the beauty device 100 is attached to the user's skin S, the first electrode 16 and the sheet electrode 50, which are skin electrodes, come into contact with the user's skin S, and the apparatus main body 10 is operated.
  • the pulse wave is applied to the skin S from the pulse wave generation portion, the first electrode 16 and the sheet electrode 50 are electrically conducted through the user's skin S, and the pulse wave is applied to the user's skin S.
  • the beauty device of the present invention is provided with additional functions such as ion introduction function, ion derivation function, EMS, sound wave vibration, radio wave generation function, LED generation function, heating function, cooling function and the like, if necessary. May be good.
  • the cosmetology device / method of the present invention may be used in combination with other treatments.
  • Other treatments include, but are not limited to, application of various stimuli such as the above-mentioned light stimulus and physical stimulus, application of stimulus by human hand, application of cosmetics, and the like.
  • any cosmetics such as gel, cream, lotion, hyaluronic acid, collagen, vitamins, and moisturizers that promote the beauty effect are used in combination with the skin, and the present invention is applied on the skin. You may apply the beauty equipment by wearing the sheet.
  • the method of the present invention is intended for beauty and may not be a treatment method used by doctors and medical professionals.
  • the present invention also provides a cosmetological counseling method that supports a cosmetological act of the subject, including presenting the cosmetological method / device of the present invention to the subject.
  • Example 1> ⁇ Collagen production promoting action by electrical stimulation> METHODS:
  • a cell reactor was prepared by the method described in N. Tandon et al., Nat. Protocol. 4 (2009) 155-173.
  • a resistance of 1 k ⁇ was applied to human fibroblasts (Normal Human Thermal Fiberblast manufactured by ATCC in the United States) in a cell reactor using a voltage divider, and a pulse wave generating device was used to generate 1 Hz, 500 Hz, 2000 Hz pulse waves (5 V, 5 ⁇ A). The stimulus was given for 2 hours.
  • FIG. 120 shows a waveform at 2000 Hz. Even in the case of 1 Hz and 500 Hz, they have the same pulse-like waveform except that only the frequency is different.
  • the amount of collagen in fibroblasts was measured as follows using a Sircol TM soluble collagen assay kit (Biocolor Ltd.). 1.0 ml of Sircol TM dye reagent is added to a tube containing 100 ⁇ l of the above fibroblast supernatant. Cover the tube and mix manually at 5 minute intervals for a total of 30 minutes. The tube is then transferred to a microcentrifuge to remove unbound dye by suction. After adding 750 ⁇ l of ice-cold acid-salt wash reagent, transfer the tube to a microcentrifuge and centrifuge at 12,000 rpm for 10 minutes. The acid-salt cleaning reagent is removed by suction and 250 ⁇ l of alkaline reagent is added to each tube.
  • a Sircol TM soluble collagen assay kit Biocolor Ltd.
  • the collagen-binding pigment is released into the solution using a vortex mixture. Then, 200 ⁇ l of the solution in each tube is transferred to the wells of the 96-well plate. Read at 555 nm using a plate reader (Thermo Electron Corporation). The quantification is performed by triplicate, and the case where no electrical stimulation is applied to the cells is used as a control and contrasted. The concentration of collagen produced is determined by contrasting with the calibration curve and standardized by the number of cells lysed by the assay.
  • the results are shown in FIG.
  • the frequencies were 500 Hz and 2000 Hz
  • high collagen production promoting effects were observed, about 2.0 times and about 6.0 times, respectively, as compared with the subject.
  • remarkable collagen production is observed when the frequency is 2000 Hz, and it can be seen that the higher the frequency, the more the collagen production is promoted.
  • the apparatus of the present invention has the effect of promoting collagen production in skin cells simply by applying a skin electrode to the skin and applying a pulse wave at a high frequency.
  • the gel pad was connected to the device of the present invention, and the skin was subjected to electrical stimulation of a pulse wave of 5 V, 250 ⁇ A, 500 Hz for 20 minutes.
  • the pad was removed from the skin, and at 15, 30, 45, and 60 minutes, the water content of the skin was measured over time with a corneometer. As a control, the water content was also measured when the cosmetic was applied for the same time without the pulse wave and when neither the pulse wave nor the cosmetic was given.
  • the result of skin water content is shown in FIG. It can be seen that after 20 minutes of application, a water content of 20 au or more is maintained for 60 minutes or more after application. The effect was remarkable even when compared with the control using only the cosmetics.
  • the device of the present invention can increase the water content of the skin and moisturize the skin simply by applying a skin electrode to the skin and applying a pulse wave at a high frequency.
  • Example 3> ⁇ Wrinkle improvement effect by pulse wave stimulation> The same electrical stimulation was applied to the same subjects as in Example 2 except that wrinkles were measured by the following method instead of water content measurement, and the wrinkle improvement effect was investigated. Skin wrinkles were imaged using an ANTERA 3D camera for skin analysis.
  • the results are shown in FIG.
  • the figure below shows an actual photograph of the skin taken with an ANTERA 3D camera
  • the figure above is an image of the surface morphology of the part of the skin corresponding to the figure below. It can be seen that the wrinkle improving effect is maintained even after 7 hours have passed and 48 hours have passed since the stimulus was applied for 20 minutes.
  • the device of the present invention has an effect of improving wrinkles on the skin simply by applying a skin electrode to the skin and applying a pulse wave at a high frequency.
  • Example 4> ⁇ Wrinkle improving effect by multiple electrical stimuli> The same subjects as in Examples 2 and 3 were given the same 20-minute electrical stimulation except that the electrical stimulation was applied three times after 0 hour, 24 hours, and 48 hours. Skin wrinkles were imaged using an ANTERA 3D camera and the wrinkle depth was quantified by determining the Indentation Index ( ⁇ m) using Miravex 1 software.
  • the result of wrinkle measurement is shown in FIG. It decreased by about 6.0 by the first stimulus, but then returned to the original level, but decreased by about 2.0 by the second stimulus and further decreased by the third stimulus. It was found that the wrinkle improving effect was further enhanced by applying a plurality of stimuli in this way as compared with a single stimulus.
  • the beauty device of the present invention has the effects of promoting collagen production in the skin, moisturizing, and improving wrinkles.
  • the collagen production of the skin is promoted, moisturized, and wrinkles are improved, it is effective for the elasticity and elasticity of the skin.
  • Example 5 For the purpose of demonstrating that the device of the present invention exerts an excellent cosmetic effect, the effect was compared with a commercially available facial device. As a commercially available facial device, another company's product was used. The device activates the skin by passing a weak electric current through the skin. The wrinkle reducing effect was investigated by determining the indentation index ( ⁇ m) and quantifying the wrinkle depth in the same manner as in Example 4. The result is shown in FIG. “Before application” in measurement 1 on the left side of the figure indicates the dent index of the application site immediately before application by another company's product. “Gel application” in measurement 2 indicates the dent index of the skin area to which only gel application is applied.
  • the dent index in which only the gel application was applied was measured. “After application” in measurement 3 indicates the dent index at the location where the gel was applied and the current stimulus was applied.
  • the current stimulation was performed by giving the current stimulation to the skin for 5 minutes according to the instruction manual of the product of another company. Since there is no difference in the dent index between measurements 2 and 3, it is considered that the effect seen by applying the products of other companies is not the effect of electrical stimulation but the effect of gel application. Therefore, it can be seen that the wrinkle reduction effect of the current stimulation of other companies' products cannot be expected so much if it is limited to the effect using the dent index as an index.
  • the right side of FIG. 18 shows the amount of change in the depression index with respect to “before application” of measurement 1.
  • the amount of change "after application” is the value obtained by subtracting the amount of change in ⁇ gel application only> from the amount of change in ⁇ gel application + current stimulation>, and the effect of using the dent index as an index is the current stimulation by other companies' products. It is clear from this figure that we cannot expect it.
  • FIG. 197 A direct comparison test was conducted between the apparatus of the present invention and a product of another company under the same environment. The result is shown in FIG. 197.
  • "Before application” on the left side of the figure shows the dent index of the part where only the gel is applied in the case of another company's product, and in the case of the present invention, shows the dent index of the skin in the state where no treatment is applied.
  • “After application” indicates the dent index of the portion where the gel is applied and the current stimulus is applied in the case of another company's product, and in the case of the present invention, the dent index measured after applying a 0.5 kHz pulse for 20 minutes is indicated. In the case of the device of the present invention, no cosmetics such as gel is used.
  • the right side of FIG. 19 shows the amount of change in the depression index with respect to “before application”. From both figures, the wrinkle improvement effect using the dent index as an index cannot be expected with the current stimulation by the products of other companies, but the clear effect was confirmed by the apparatus of

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Abstract

L'objet de la présente invention concerne un procédé d'embellissement destiné à favoriser la génération de collagène cutané.　L'invention concerne un procédé d'embellissement pour favoriser la génération de collagène cutané, ledit procédé comprenant l'application d'un courant pulsé à la peau d'un sujet.
PCT/JP2021/043861 2020-12-11 2021-11-30 Procédé d'embellissement destiné à favoriser la génération de collagène cutané WO2022124138A1 (fr)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0647096A (ja) * 1992-06-22 1994-02-22 Drug Delivery Syst Inc 電気的経皮薬剤マルチシグナルアプリケータ
JP2008539051A (ja) * 2005-04-28 2008-11-13 キャロル コール カンパニー マイクロダーマルトーン皮膚刺激装置
JP2015150271A (ja) * 2014-02-17 2015-08-24 Ｙｓｉ株式会社 美容器具
JP2017534592A (ja) * 2014-09-29 2017-11-24 イーエルシー マネージメント エルエルシー マスク又はパッチ形態でのマイクロカレントによるスキンケアトリートメントの標的化及び個別化送達
CN109789306A (zh) * 2016-09-27 2019-05-21 株式会社 Lg 生活健康 皮肤管理装置
JP2020185207A (ja) * 2019-05-15 2020-11-19 ヤーマン株式会社 美容器、及びその制御方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0647096A (ja) * 1992-06-22 1994-02-22 Drug Delivery Syst Inc 電気的経皮薬剤マルチシグナルアプリケータ
JP2008539051A (ja) * 2005-04-28 2008-11-13 キャロル コール カンパニー マイクロダーマルトーン皮膚刺激装置
JP2015150271A (ja) * 2014-02-17 2015-08-24 Ｙｓｉ株式会社 美容器具
JP2017534592A (ja) * 2014-09-29 2017-11-24 イーエルシー マネージメント エルエルシー マスク又はパッチ形態でのマイクロカレントによるスキンケアトリートメントの標的化及び個別化送達
CN109789306A (zh) * 2016-09-27 2019-05-21 株式会社 Lg 生活健康 皮肤管理装置
JP2020185207A (ja) * 2019-05-15 2020-11-19 ヤーマン株式会社 美容器、及びその制御方法

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