WO2022109250A1 - Bouchons et procédés pour leur translation à travers un tube - Google Patents
Bouchons et procédés pour leur translation à travers un tube Download PDFInfo
- Publication number
- WO2022109250A1 WO2022109250A1 PCT/US2021/060060 US2021060060W WO2022109250A1 WO 2022109250 A1 WO2022109250 A1 WO 2022109250A1 US 2021060060 W US2021060060 W US 2021060060W WO 2022109250 A1 WO2022109250 A1 WO 2022109250A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stopper
- force
- proximal end
- plunger rod
- rib
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 100
- 238000003780 insertion Methods 0.000 claims abstract description 173
- 230000037431 insertion Effects 0.000 claims abstract description 173
- 238000007789 sealing Methods 0.000 claims abstract description 113
- 229920000642 polymer Polymers 0.000 claims abstract description 97
- 230000009467 reduction Effects 0.000 claims abstract description 54
- 230000004888 barrier function Effects 0.000 claims abstract description 8
- 229920001296 polysiloxane Polymers 0.000 claims description 12
- 230000001225 therapeutic effect Effects 0.000 claims description 10
- 238000013519 translation Methods 0.000 abstract description 54
- 239000000314 lubricant Substances 0.000 abstract description 32
- 229940090047 auto-injector Drugs 0.000 abstract description 6
- 239000010410 layer Substances 0.000 description 66
- 239000004223 monosodium glutamate Substances 0.000 description 18
- 238000012546 transfer Methods 0.000 description 17
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- 238000013459 approach Methods 0.000 description 11
- 230000006835 compression Effects 0.000 description 11
- 238000007906 compression Methods 0.000 description 11
- 239000007788 liquid Substances 0.000 description 11
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 11
- 239000004810 polytetrafluoroethylene Substances 0.000 description 11
- 238000004519 manufacturing process Methods 0.000 description 10
- 239000000463 material Substances 0.000 description 10
- 229920002313 fluoropolymer Polymers 0.000 description 9
- 239000004811 fluoropolymer Substances 0.000 description 9
- 239000013536 elastomeric material Substances 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 6
- 229920001971 elastomer Polymers 0.000 description 6
- 230000002093 peripheral effect Effects 0.000 description 5
- 230000007704 transition Effects 0.000 description 5
- 229960000074 biopharmaceutical Drugs 0.000 description 4
- 229920001577 copolymer Polymers 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000806 elastomer Substances 0.000 description 4
- 229920000295 expanded polytetrafluoroethylene Polymers 0.000 description 4
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 4
- 229920001774 Perfluoroether Polymers 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 239000012633 leachable Substances 0.000 description 3
- 239000010687 lubricating oil Substances 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 239000004812 Fluorinated ethylene propylene Substances 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 239000012632 extractable Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920009441 perflouroethylene propylene Polymers 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 239000005060 rubber Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229920002725 thermoplastic elastomer Polymers 0.000 description 2
- 229920006342 thermoplastic vulcanizate Polymers 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
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- 238000012228 RNA interference-mediated gene silencing Methods 0.000 description 1
- 239000002174 Styrene-butadiene Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- 229920005557 bromobutyl Polymers 0.000 description 1
- MTAZNLWOLGHBHU-UHFFFAOYSA-N butadiene-styrene rubber Chemical compound C=CC=C.C=CC1=CC=CC=C1 MTAZNLWOLGHBHU-UHFFFAOYSA-N 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000003486 chemical etching Methods 0.000 description 1
- 229920005556 chlorobutyl Polymers 0.000 description 1
- 229920006026 co-polymeric resin Polymers 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
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- 238000005520 cutting process Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 210000001671 embryonic stem cell Anatomy 0.000 description 1
- HQQADJVZYDDRJT-UHFFFAOYSA-N ethene;prop-1-ene Chemical group C=C.CC=C HQQADJVZYDDRJT-UHFFFAOYSA-N 0.000 description 1
- 229920001973 fluoroelastomer Polymers 0.000 description 1
- 230000009368 gene silencing by RNA Effects 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 229920005555 halobutyl Polymers 0.000 description 1
- 125000004968 halobutyl group Chemical group 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
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- 150000002825 nitriles Chemical class 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920001084 poly(chloroprene) Polymers 0.000 description 1
- 239000002952 polymeric resin Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920000379 polypropylene carbonate Polymers 0.000 description 1
- 229920002620 polyvinyl fluoride Polymers 0.000 description 1
- 229940071643 prefilled syringe Drugs 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
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- 239000000376 reactant Substances 0.000 description 1
- 238000007788 roughening Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000011115 styrene butadiene Substances 0.000 description 1
- 229920003048 styrene butadiene rubber Polymers 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M5/31513—Piston constructions to improve sealing or sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M2005/3131—Syringe barrels specially adapted for improving sealing or sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
- A61M2207/10—Device therefor
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202180077767.2A CN116457043A (zh) | 2020-11-20 | 2021-11-19 | 止挡件和使止挡件平移通过管的方法 |
KR1020237020492A KR20230110316A (ko) | 2020-11-20 | 2021-11-19 | 스토퍼 및 튜브를 통한 스토퍼 병진 방법 |
AU2021382676A AU2021382676A1 (en) | 2020-11-20 | 2021-11-19 | Stoppers and methods of translating the same through a tube |
JP2023530616A JP2023550943A (ja) | 2020-11-20 | 2021-11-19 | ストッパ及びこれをチューブの中で並進させる方法 |
EP21827310.0A EP4247459A1 (fr) | 2020-11-20 | 2021-11-19 | Bouchons et procédés pour leur translation à travers un tube |
US18/038,080 US20240001036A1 (en) | 2020-11-20 | 2021-11-19 | Stoppers and methods of translating the same through a tube |
CA3196910A CA3196910A1 (fr) | 2020-11-20 | 2021-11-19 | Bouchons et procedes pour leur translation a travers un tube |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063116209P | 2020-11-20 | 2020-11-20 | |
US63/116,209 | 2020-11-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2022109250A1 true WO2022109250A1 (fr) | 2022-05-27 |
Family
ID=79024397
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2021/060060 WO2022109250A1 (fr) | 2020-11-20 | 2021-11-19 | Bouchons et procédés pour leur translation à travers un tube |
Country Status (8)
Country | Link |
---|---|
US (1) | US20240001036A1 (fr) |
EP (1) | EP4247459A1 (fr) |
JP (1) | JP2023550943A (fr) |
KR (1) | KR20230110316A (fr) |
CN (1) | CN116457043A (fr) |
AU (1) | AU2021382676A1 (fr) |
CA (1) | CA3196910A1 (fr) |
WO (1) | WO2022109250A1 (fr) |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5708044A (en) | 1994-09-02 | 1998-01-13 | W. L. Gore & Associates, Inc. | Polyetrafluoroethylene compositions |
US6541589B1 (en) | 2001-10-15 | 2003-04-01 | Gore Enterprise Holdings, Inc. | Tetrafluoroethylene copolymer |
US7531611B2 (en) | 2005-07-05 | 2009-05-12 | Gore Enterprise Holdings, Inc. | Copolymers of tetrafluoroethylene |
US8637144B2 (en) | 2007-10-04 | 2014-01-28 | W. L. Gore & Associates, Inc. | Expandable TFE copolymers, method of making, and porous, expended articles thereof |
US9139669B2 (en) | 2009-03-24 | 2015-09-22 | W. L. Gore & Associates, Inc. | Expandable functional TFE copolymer fine powder, the expandable functional products obtained therefrom and reaction of the expanded products |
EP3058975A1 (fr) * | 2015-02-18 | 2016-08-24 | Sumitomo Rubber Industries Limited | Seringue préremplie, joint destiné à être utilisé avec une seringue pré-remplie, et procédé de production de joint |
WO2017123835A1 (fr) * | 2016-01-15 | 2017-07-20 | W.L. Gore & Associates, Inc. | Ensembles piston de seringue |
EP3342439A1 (fr) * | 2016-12-28 | 2018-07-04 | Sumitomo Rubber Industries, Ltd. | Seringue médicale |
EP3409311A1 (fr) * | 2017-06-02 | 2018-12-05 | Sumitomo Rubber Industries, Ltd. | Procédé de fabrication d'un joint de seringue et seringue comprenant le joint |
WO2020112612A1 (fr) * | 2018-11-27 | 2020-06-04 | W. L. Gore & Associates, Inc. | Procédé d'insertion d'un bouchon exempt de lubrifiant dans un cylindre exempt de lubrifiant ou un tube de cartouche exempt de lubrifiant, et système d'assemblage associé |
WO2020118275A1 (fr) * | 2018-12-07 | 2020-06-11 | Abrams Robert S | Systèmes de seringues et de joints améliorés |
-
2021
- 2021-11-19 US US18/038,080 patent/US20240001036A1/en active Pending
- 2021-11-19 KR KR1020237020492A patent/KR20230110316A/ko unknown
- 2021-11-19 CA CA3196910A patent/CA3196910A1/fr active Pending
- 2021-11-19 WO PCT/US2021/060060 patent/WO2022109250A1/fr active Application Filing
- 2021-11-19 AU AU2021382676A patent/AU2021382676A1/en active Pending
- 2021-11-19 JP JP2023530616A patent/JP2023550943A/ja active Pending
- 2021-11-19 EP EP21827310.0A patent/EP4247459A1/fr active Pending
- 2021-11-19 CN CN202180077767.2A patent/CN116457043A/zh active Pending
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5708044A (en) | 1994-09-02 | 1998-01-13 | W. L. Gore & Associates, Inc. | Polyetrafluoroethylene compositions |
US6541589B1 (en) | 2001-10-15 | 2003-04-01 | Gore Enterprise Holdings, Inc. | Tetrafluoroethylene copolymer |
US7531611B2 (en) | 2005-07-05 | 2009-05-12 | Gore Enterprise Holdings, Inc. | Copolymers of tetrafluoroethylene |
US8637144B2 (en) | 2007-10-04 | 2014-01-28 | W. L. Gore & Associates, Inc. | Expandable TFE copolymers, method of making, and porous, expended articles thereof |
US9139669B2 (en) | 2009-03-24 | 2015-09-22 | W. L. Gore & Associates, Inc. | Expandable functional TFE copolymer fine powder, the expandable functional products obtained therefrom and reaction of the expanded products |
EP3058975A1 (fr) * | 2015-02-18 | 2016-08-24 | Sumitomo Rubber Industries Limited | Seringue préremplie, joint destiné à être utilisé avec une seringue pré-remplie, et procédé de production de joint |
WO2017123835A1 (fr) * | 2016-01-15 | 2017-07-20 | W.L. Gore & Associates, Inc. | Ensembles piston de seringue |
EP3342439A1 (fr) * | 2016-12-28 | 2018-07-04 | Sumitomo Rubber Industries, Ltd. | Seringue médicale |
EP3409311A1 (fr) * | 2017-06-02 | 2018-12-05 | Sumitomo Rubber Industries, Ltd. | Procédé de fabrication d'un joint de seringue et seringue comprenant le joint |
WO2020112612A1 (fr) * | 2018-11-27 | 2020-06-04 | W. L. Gore & Associates, Inc. | Procédé d'insertion d'un bouchon exempt de lubrifiant dans un cylindre exempt de lubrifiant ou un tube de cartouche exempt de lubrifiant, et système d'assemblage associé |
WO2020118275A1 (fr) * | 2018-12-07 | 2020-06-11 | Abrams Robert S | Systèmes de seringues et de joints améliorés |
Also Published As
Publication number | Publication date |
---|---|
AU2021382676A1 (en) | 2023-07-06 |
KR20230110316A (ko) | 2023-07-21 |
EP4247459A1 (fr) | 2023-09-27 |
JP2023550943A (ja) | 2023-12-06 |
US20240001036A1 (en) | 2024-01-04 |
CA3196910A1 (fr) | 2022-05-27 |
CN116457043A (zh) | 2023-07-18 |
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