WO2022108728A1 - Procédé, système et appareil pour une unité de traitement sanguin - Google Patents
Procédé, système et appareil pour une unité de traitement sanguin Download PDFInfo
- Publication number
- WO2022108728A1 WO2022108728A1 PCT/US2021/057146 US2021057146W WO2022108728A1 WO 2022108728 A1 WO2022108728 A1 WO 2022108728A1 US 2021057146 W US2021057146 W US 2021057146W WO 2022108728 A1 WO2022108728 A1 WO 2022108728A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- lysing
- sample
- lvc
- syringe
- transfer assembly
- Prior art date
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 36
- 239000008280 blood Substances 0.000 title claims abstract description 36
- 238000000034 method Methods 0.000 title claims description 42
- 238000012545 processing Methods 0.000 title description 22
- 239000000523 sample Substances 0.000 claims abstract description 108
- 230000002934 lysing effect Effects 0.000 claims abstract description 52
- 238000012546 transfer Methods 0.000 claims abstract description 45
- 239000012528 membrane Substances 0.000 claims abstract description 33
- 244000052769 pathogen Species 0.000 claims abstract description 27
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- 230000001717 pathogenic effect Effects 0.000 claims abstract description 16
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- 238000005406 washing Methods 0.000 claims description 7
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- 241000700605 Viruses Species 0.000 abstract description 12
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0668—Trapping microscopic beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/16—Reagents, handling or storing thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8822—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving blood
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Ecology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Les modes de réalisation de l'invention peuvent être utilisés, entre autres, pour extraire des particules du sang. Les particules peuvent comprendre des agents pathogènes, des virus, des bactéries et d'autres micro-organismes présents dans le sang de mammifère. Un mode de réalisation de l'invention concerne un système pour détecter un ou plusieurs agents pathogènes transmis par le sang. Le système donné à titre d'exemple comprend : un ensemble de transfert présentant un tube et une aiguille creuse, l'aiguille creuse étant située au centre à l'intérieur du tube d'ensemble de transfert et conçue pour communiquer un matériau d'échantillon à travers celle-ci; une seringue de lyse destinée à être accouplée à l'ensemble de transfert, la seringue de lyse comprenant un ou plusieurs réactifs de lyse et un piston pouvant être activé pour recevoir le matériau d'échantillon à travers l'ensemble de transfert; et un concentrateur à grand volume (LVC) destiné à être accouplé de manière étanche à la seringue de lyse et à séparer au moins un agent pathogène à partir du matériau d'échantillon, le LVC comprenant en outre : un support de filtre, une membrane, un élément de retenue et une partie filetée.
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063117446P | 2020-11-23 | 2020-11-23 | |
| US202063117442P | 2020-11-23 | 2020-11-23 | |
| US202061117434P | 2020-11-23 | 2020-11-23 | |
| US63/117,446 | 2020-11-23 | ||
| US61/117,434 | 2020-11-23 | ||
| US63/117,442 | 2020-11-23 | ||
| PCT/US2021/045630 WO2022108634A1 (fr) | 2020-11-23 | 2021-08-12 | Procédé, système et appareil de détection |
| US17/400,136 US20220162714A1 (en) | 2020-11-23 | 2021-08-12 | Method, system and apparatus for detection |
| US17/400,136 | 2021-08-12 | ||
| USPCT/US2021/045630 | 2021-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2022108728A1 true WO2022108728A1 (fr) | 2022-05-27 |
Family
ID=81709621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2021/057146 WO2022108728A1 (fr) | 2020-11-23 | 2021-10-28 | Procédé, système et appareil pour une unité de traitement sanguin |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2022108728A1 (fr) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100288060A1 (en) * | 2009-05-15 | 2010-11-18 | BIOMéRIEUX, INC. | Device for sampling a specimen container |
| US20140305196A1 (en) * | 2013-04-15 | 2014-10-16 | Becton, Dickinson And Company | Biological Fluid Collection Device and Biological Fluid Separation and Testing System |
| US20180250636A1 (en) * | 2015-11-05 | 2018-09-06 | Eiken Kagaku Kabushiki Kaisha | Discharge member with filter |
| US20180289304A1 (en) * | 2015-07-24 | 2018-10-11 | Kurin, Inc. | Blood sample optimization system and blood contaminant sequestration device and method |
| US20190091681A1 (en) * | 2016-03-28 | 2019-03-28 | Tangen Biosciences, Inc. | Apparatus and method for extracting pathogens from biological samples |
-
2021
- 2021-10-28 WO PCT/US2021/057146 patent/WO2022108728A1/fr active Application Filing
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100288060A1 (en) * | 2009-05-15 | 2010-11-18 | BIOMéRIEUX, INC. | Device for sampling a specimen container |
| US20140305196A1 (en) * | 2013-04-15 | 2014-10-16 | Becton, Dickinson And Company | Biological Fluid Collection Device and Biological Fluid Separation and Testing System |
| US20180289304A1 (en) * | 2015-07-24 | 2018-10-11 | Kurin, Inc. | Blood sample optimization system and blood contaminant sequestration device and method |
| US20180250636A1 (en) * | 2015-11-05 | 2018-09-06 | Eiken Kagaku Kabushiki Kaisha | Discharge member with filter |
| US20190091681A1 (en) * | 2016-03-28 | 2019-03-28 | Tangen Biosciences, Inc. | Apparatus and method for extracting pathogens from biological samples |
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