WO2022091403A1 - 生体組織のための測定装置、吸引装置、生体組織のための測定方法、及びプログラム - Google Patents

生体組織のための測定装置、吸引装置、生体組織のための測定方法、及びプログラム Download PDF

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Publication number
WO2022091403A1
WO2022091403A1 PCT/JP2020/041022 JP2020041022W WO2022091403A1 WO 2022091403 A1 WO2022091403 A1 WO 2022091403A1 JP 2020041022 W JP2020041022 W JP 2020041022W WO 2022091403 A1 WO2022091403 A1 WO 2022091403A1
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WIPO (PCT)
Prior art keywords
measuring device
temperature
optical sensor
unit
optical
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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PCT/JP2020/041022
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English (en)
French (fr)
Japanese (ja)
Inventor
啓貴 内藤
雄太 吉村
啓之 久保田
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Japan Tobacco Inc
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Japan Tobacco Inc
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Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Priority to PCT/JP2020/041022 priority Critical patent/WO2022091403A1/ja
Priority to EP20959918.2A priority patent/EP4238487A1/en
Priority to KR1020227040624A priority patent/KR20230002917A/ko
Priority to JP2022558800A priority patent/JP7453407B2/ja
Publication of WO2022091403A1 publication Critical patent/WO2022091403A1/ja
Priority to US18/071,374 priority patent/US12023125B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0088—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for oral or dental tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/087—Measuring breath flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/14517—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for sweat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/443—Evaluating skin constituents, e.g. elastin, melanin, water
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
    • A61B5/4538—Evaluating a particular part of the muscoloskeletal system or a particular medical condition
    • A61B5/4542—Evaluating the mouth, e.g. the jaw
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
    • A61B5/4538—Evaluating a particular part of the muscoloskeletal system or a particular medical condition
    • A61B5/4542—Evaluating the mouth, e.g. the jaw
    • A61B5/4552—Evaluating soft tissue within the mouth, e.g. gums or tongue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A61B5/682—Mouth, e.g., oral cavity; tongue; Lips; Teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6887—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient mounted on external non-worn devices, e.g. non-medical devices
    • A61B5/6898—Portable consumer electronic devices, e.g. music players, telephones, tablet computers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4738—Diffuse reflection, e.g. also for testing fluids, fibrous materials
    • G01N21/474—Details of optical heads therefor, e.g. using optical fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0242—Operational features adapted to measure environmental factors, e.g. temperature, pollution
    • A61B2560/0247—Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value
    • A61B2560/0252—Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value using ambient temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0271—Thermal or temperature sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3554—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for determining moisture content
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/121—Correction signals
    • G01N2201/1211—Correction signals for temperature

Definitions

  • the present disclosure relates to a measuring device for a living tissue, a suction device, a measuring method for a living tissue, and a program.
  • a measuring device for measuring the amount of a substance of a living tissue such as water in the oral cavity is known.
  • various sensors are adopted for measuring a living tissue.
  • An example of a sensor applied to a measuring device for a living tissue is a sensor (optical sensor) using an optical element.
  • a measuring mechanism for measuring the amount of substance in a living tissue to a smoking device carried by a user such as a smoking device.
  • a smoking device equipped with a measuring device for measuring the amount of substance of a living tissue is also an example of a measuring device for a living tissue.
  • the amount and concentration of nicotine metabolites in the saliva of a user who is a smoker are measured.
  • the measuring device to which the optical sensor is applied is greatly affected by the temperature at the time of heat generation, and in order to apply a sufficient heat dissipation mechanism, it is usually a large-sized device used in a laboratory or a factory. Further, since it takes time from the activation of the optical sensor to the stabilization of the operation, the measurement time is usually long. That is, the biological tissue measuring device to which the optical sensor is applied has not been easily available to the user.
  • the measuring mechanism is applied to smoking equipment, it is assumed that heating is accompanied when the smoking component is generated, and it is necessary to particularly consider the influence of heating on the optical sensor.
  • a measuring device for living tissue is provided.
  • the light emitting portion irradiates the measured object with light through the measuring surface in contact with the measured object, which is a part of the biological tissue, and the light receiving portion receives the reflected light reflected from the measured object.
  • An optical sensor that measures the optical data of the object to be measured, a temperature sensor that measures the temperature of the optical sensor, and the object to be measured that processes the optical data based on the temperature of the optical sensor and based on the processed optical data. It is provided with a data processing unit for deriving the measurement result.
  • the measuring device of the second aspect includes that in the measuring device of the first aspect, the processing of the optical data by the data processing unit selects the optical data in which the temperature of the optical sensor substantially corresponds to the specified temperature.
  • the measuring device of the third viewpoint is configured such that the designated temperature is dynamically determined in the measuring device of the second viewpoint based on the environmental temperature when the measuring device is started.
  • the processing of the optical data by the data processing unit produces the optical data for each wavelength of the reflected light based on the temperature of the optical sensor. Includes correction.
  • a model of the rate of change of the light intensity with respect to the temperature of the optical sensor is predetermined for each wavelength and stored in the storage unit, and the optical data uses the model. Is configured to be corrected.
  • the light emitting portion when the temperature of the optical sensor is equal to or less than a predetermined threshold value, the light emitting portion is activated and the temperature of the optical sensor is predetermined.
  • the light emitting part is configured to be deactivated when the temperature is higher than the threshold value.
  • the measuring device of the seventh viewpoint includes a window whose measuring surface has light transmission in any of the measuring devices of the first to sixth viewpoints.
  • the measuring device of the eighth viewpoint is arranged so that the measuring surface of the measuring device of the seventh viewpoint is located between the light receiving unit and the light emitting unit on the gradient surface.
  • the measuring device of the ninth viewpoint is the measuring device of the eighth viewpoint, and the angle of the gradient of the gradient surface is 15 degrees or less.
  • the light emitting unit, the light receiving unit, and the measuring surface are connected to each other through an optical fiber in any of the measuring devices of the first to sixth viewpoints.
  • the measuring device is the measuring device according to the tenth aspect, wherein the optical fiber includes a first fiber connecting the light emitting portion and the measuring surface and a second fiber connecting the light receiving portion and the measuring surface.
  • the distance between the end of the fiber on the measurement surface side and the end of the second fiber on the measurement surface side is within the range of 0 to 3 mm.
  • the measuring device of the twelfth viewpoint is any of the measuring devices of the first to eleventh viewpoints, in which the measuring device is provided in the suction device and is integrally configured with the suction device.
  • the temperature sensor is arranged between the air flow path included in the suction device and the optical sensor in the measuring device of the thirteenth viewpoint.
  • the measuring device of the 14th viewpoint is detachably attached to the suction device in any of the measuring devices of the 1st to 11th viewpoints.
  • the object to be measured is the oral tissue in any of the measuring devices of the twelfth viewpoint to the fourteenth viewpoint.
  • a suction device provided with any measuring device from the 1st viewpoint to the 15th viewpoint is provided.
  • a measuring method for living tissue is provided.
  • Such a measurement method is a step in which a temperature sensor measures the temperature of an optical sensor and a step in which the optical sensor measures optical data, and the measurement is performed through a measurement surface in contact with an object to be measured, which is a part of a biological tissue.
  • processing the optical data based on the temperature of the optical sensor, and processing the optical data.
  • the method of the 18th viewpoint includes, in the method of the 17th viewpoint, the step of processing the optical data is to select the optical data in which the temperature of the optical sensor substantially corresponds to the specified temperature.
  • the method of the 19th viewpoint includes, in the method of the 17th viewpoint or the 18th viewpoint, the step of processing the optical data is to correct the optical data for each wavelength of the reflected light based on the temperature of the optical sensor.
  • a program for causing the measuring device to execute any of the methods of the 17th viewpoint to the 19th viewpoint is provided.
  • FIG. 3 is a plan view of the measuring unit of the measuring device of FIG. 1 as viewed from the front. It is a cutting view which looked at the measuring part of the measuring apparatus of FIG. 1 from the side view.
  • It is a schematic diagram which shows the structural example of the measuring apparatus of FIG.
  • It is an operation flow diagram which shows the measurement method for the living tissue which concerns on embodiment.
  • It is operation flow diagram which shows the modification of the schematic operation flow of FIG.
  • It is a schematic graph which shows the temperature transition example of the optical sensor with the temperature control operation.
  • It is a schematic graph which shows the model example of the change rate of a light intensity.
  • FIG. 3 is a plan view of the measuring unit of the measuring device of FIG. 1 as viewed from the front. It is a cutting view which looked at the measuring part of the measuring apparatus of FIG. 1 from the side view.
  • It is a schematic diagram which shows the structural example of the measuring apparatus of FIG.
  • It is an operation flow diagram which shows the measurement method for the living tissue which concerns on
  • FIG. 1 It is a schematic diagram which shows the other configuration example of a suction device. It is a schematic diagram which shows the external view of the suction device of FIG. It is a schematic diagram which shows the arrangement example of the element of the suction device of FIG. It is a schematic diagram which shows the other arrangement example of the element of the suction device of FIG. It is a schematic diagram which shows the other arrangement example of the element of the suction device of FIG. It is a schematic diagram which shows the other arrangement example of the element of the suction device of FIG. It is a schematic diagram which shows the other arrangement example of the element of the suction device of FIG. It is a schematic diagram which shows the example which attached the measuring device to the suction device of FIG. It is a schematic diagram which shows the other example which attached the measuring device to the suction device of FIG.
  • the measuring device for living tissue is a device using an optical sensor, which is miniaturized so that the user can hold it with one hand. That is, the measurement is performed by irradiating the living tissue with light using an optical sensor.
  • an optical sensor includes a light receiving unit and a light emitting unit. Then, the measuring device is brought into contact with the object to be measured, which is a part of the biological tissue, the light emitting portion irradiates the light, and the light receiving portion receives the reflected light reflected from the measured object, whereby the optics of the measured object is received. Measure the data.
  • an optical sensor has high robustness without exposing the measuring element (optical element). Further, since a film or the like for protecting the element is not required, the possibility of use is high. Further, since it is not necessary to bring the optical element into direct contact with the living tissue, it does not cause discomfort to the user.
  • a measuring device using an optical sensor which is miniaturized so that the user can hold it with one hand, is susceptible to noise due to heat generation when the light emitting element emits light. Specifically, when the light emitting element generates heat and the temperature of the light emitting element rises, the peak wavelength emitted from the light emitting element becomes large. As a result, the light intensity of the reflected light received by the light receiving element is relatively reduced.
  • the measuring device since the user will carry a miniaturized measuring device, it is expected that the measuring device will be used seasonally and indoors and outdoors. That is, it is easily affected by the temperature change of the external environment. It is expected that the measurement data will fluctuate greatly due to these temperature factors, which will adversely affect the measurement accuracy of the measuring device.
  • the measuring device for living tissue further includes a temperature sensor for measuring the temperature of the optical sensor in addition to the above-mentioned optical sensor configuration. Then, the temperature information and the optical data of the optical sensor are associated with each other. More specifically, the optical data acquired by the optical sensor is appropriately processed based on the temperature of the optical sensor acquired by the temperature sensor, and the measurement result regarding the biological tissue is derived based on the processed optical data. As a result, even in a miniaturized measuring device, it is possible to derive an appropriate measurement result while considering the influence of noise due to heat generation when the light emitting element emits light.
  • the object to be measured measured by the measuring device for living tissue may be any as long as it can be measured by an optical sensor. Since the optical sensor can measure a plurality of wavelengths, it is possible to simultaneously measure a wide variety of substances in living tissue.
  • Living tissues include the oral cavity, skin on the surface of the body, and the like.
  • substances in saliva moisture, glucose, etc.
  • physical characteristics of the oral tissue for example, color of the oral tissue, degree of roughness of the tongue
  • etc. are analyzed to derive the measurement result. ..
  • the object to be measured is the skin on the surface of the body, for example, substances in sweat (moisture, etc.) and physical properties of the skin (dryness of the skin, etc.) may be mentioned.
  • This measuring device can also be applied to measure the amount and physical properties of substances other than living tissues.
  • FIG. 1 is an overall perspective view of the measuring device 10 for a living tissue according to the present embodiment.
  • 2A and 2B are schematic views of the measuring unit 20 included in the measuring device 10. Specifically, FIG. 2A is a plan view of the measuring unit 20 as viewed from the front, and FIG. 2B is a cross-sectional view of the side surface of the measuring unit 20 cut along the line AA of FIG.
  • FIGS. 1, 2A and 2B define an XYZ Cartesian coordinate system. That is, the Z-axis faces vertically upward, the XY plane cuts the measuring device 10 in the horizontal direction, and the Y-axis faces the direction extending from the front surface to the back surface of the measuring device 10.
  • the illustrated XYZ coordinate system will be used in this sense.
  • the measuring device 10 is a device that has been miniaturized so that the user can hold it with one hand.
  • the measuring device 10 includes a measuring unit 20 for contacting with a living tissue for measurement, and a main body unit 30.
  • the measuring unit 20 is arranged so as to extend in the Z-axis direction from the upper surface of the main body unit 30. Further, the measuring unit 20 forms the measuring surface 21 along the XZ plane. That is, the living tissue is measured by the user bringing the object to be measured, which is a part of the living tissue, into contact with the measurement surface 21.
  • the measurement surface 21 may be an opening.
  • the measuring unit 20 includes an optical sensor 24 including a light receiving unit 22 and a light emitting unit 23, a temperature sensor 25, and a heat emitting unit 26 inside.
  • the light receiving unit 22 and the light emitting unit 23 are arranged close to each other. More specifically, the light receiving unit 22 and the light emitting unit 23 are arranged close to each other along the vertical direction (+ Z direction) so that the light receiving unit 22 is in the upper position and the light emitting unit 23 is in the lower position. In the light emitting unit 23, each element is oriented in the ⁇ Y direction. Then, through the measuring unit 20, the light emitting unit 23 irradiates the object to be measured with light, and the light receiving unit 22 receives the reflected light reflected from the object to be measured.
  • the object to be measured is the oral cavity
  • the light emitted from the light emitting unit 23 is irradiated by the tongue and lips in the oral cavity, and the reflected light is received by the light receiving unit 22.
  • the optical data of the object to be measured is measured.
  • the arrangement of the light receiving unit 22 and the light emitting unit 23 is not limited to the above, and the light receiving unit 22 may be in the lower position and the light emitting unit 23 may be in the upper position along the + Z direction.
  • the optical data is not limited to this, and preferably includes a plurality of wavelength data of light and light intensity for each wavelength.
  • the light receiving unit 22 of the optical sensor 24 is composed of a light receiving element.
  • a photodiode (PD) is adopted as the light receiving element in order to reduce the size of the measuring device 10.
  • the light receiving unit 22 is not limited to this, and is a phototube using an external photoelectric effect (photomultiplier tube), a photomultiplier tube, a photoresistor using the internal photoelectric effect of a semiconductor, an avalanche photodiode, a photoconductive cell, and an image sensor.
  • Photomultiplier tubes, radiating photodiodes that detect heat due to light absorption, thermopile, photoelectric detectors that utilize the photoelectric effect, and the like may be adopted.
  • the light receiving unit 22 of the optical sensor 24 may include a wavelength specifying unit (not shown) that specifies and receives one or more wavelengths such as a spectroscopic element or an optical filter.
  • the spectroscopic element is not limited to this, but a diffraction grating, a prism, or the like having a mechanism having wavelength selectivity is preferable. This makes it possible to acquire a plurality of types of biological information as optical data relating to a plurality of wavelengths. That is, it is possible to measure the amounts of a plurality of substances in a living tissue at the same time.
  • the wavelength specifying portion may be integrally formed with the light receiving element.
  • the light emitting unit 23 of the optical sensor 24 is composed of a light emitting element.
  • the light emitting unit 23 is not limited to this, but may be configured by a temperature radiation light source, a heat radiation light source, an electroluminescent light source, a laser, or the like.
  • a light emitting diode (LED) is adopted as the light emitting element in order to reduce the size of the measuring device 10.
  • the light emitting element is not limited to this, and a laser diode (LD), a fluorescent lamp, or an incandescent lamp may be adopted.
  • a wideband LED may be adopted as a light emitting element.
  • the measurement surface 21 is placed on the light receiving unit 22 side (+ Y in the case of FIG. 2B) with respect to the vertical direction (+ Z direction). It is better to form a sloped surface that is sloped by an angle ⁇ (in the direction).
  • the direction of the gradient is such that the incident angle from the light emitting unit 23 to the measurement surface 21 is smaller in the + Z direction than in the case where there is no gradient. The reason for inclining the measurement surface 21 in this way is as follows.
  • the light radiated from the LED that can be adopted as the light emitting unit 23 spreads in all directions and travels straight.
  • those skilled in the art are known to maintain an intensity of 50% or more as compared with light traveling straight in the range of a radiation angle of 0 ° to 60 °.
  • a mechanism having a slit such as an optical filter
  • the angle at which the reflected light is incident on the light receiving unit 22 affects the light receiving intensity.
  • the gradient angle ⁇ is preferably adjusted in the range of 0 ° to 15 °, more preferably adjusted in the range of 1 ° to 5 ° (for example, 2 °). Is good. It should be noted that those skilled in the art will understand that when the arrangement relationship of the light receiving unit 22 and the light emitting unit 23 is exchanged in FIG. 2B, the direction of gradient is opposite (that is, it becomes ⁇ degree with respect to the + Z direction). ..
  • the temperature sensor 25 measures the temperature of the optical sensor 24.
  • the heat generated by the light emitting unit 23 itself may affect the optical data of the optical sensor 24, so it is necessary to consider the temperature of the light emitting unit 23 when measuring the data. That is, the temperature sensor 25 is arranged in the vicinity of the light emitting unit 23 so as to measure at least the temperature of the light emitting unit 23.
  • the temperature sensor 25 may be arranged at any position as long as it is in the vicinity of the light emitting unit 23.
  • the temperature of the optical sensor 24 (particularly the light emitting unit 23) measured by the temperature sensor 25 may be associated with optical data.
  • the temperature of the light receiving unit 22 may affect the measured optical data.
  • the temperature of the light receiving unit 22 can greatly affect the optical data to be measured. That is, a temperature sensor 25 for measuring the temperature of the light receiving unit 22 may be separately installed, or the temperature of both the light receiving unit 22 and the light emitting unit 23 may be measured by one temperature sensor 25.
  • the temperature sensor 25 may be configured by any one of an NTC (Negative Temperature Coefficient) thermistor, a thermocouple, a thermocouple, a platinum temperature sensor, and the like.
  • NTC Negative Temperature Coefficient
  • the heat emitting unit 26 is configured as a mechanism for releasing heat generated when the light emitting unit 23 is operating. That is, it is preferable to arrange it in the vicinity of the light emitting unit 23.
  • the heat emitting section 26 is often composed of a heat conductive plate, and in particular, is arranged behind the light emitting section 23 along the XX plane. As a result, the heat generated by the light emitting unit 23 can be released along the Z-axis direction.
  • the heat conductive plate it is preferable to use a substance having a thermal conductivity of 0.20 W / (m ⁇ K) or more, more preferably 20 W / (m ⁇ K) or more.
  • the heat release unit 26 is not limited to the heat conduction plate, and an air-cooling fan, a Pelche-type cooling mechanism, or the like may be adopted in addition to the heat conduction plate.
  • FIG. 3 is a schematic diagram of a functional configuration example of the measuring device 10 for a living tissue according to the present embodiment.
  • the measuring device 10 according to this configuration example includes a power supply unit 11, a sensor unit 12, a notification unit 13, a storage unit 14, a communication unit 15, and a control unit 16.
  • the control unit 16 includes a data processing unit 17.
  • the power supply unit 11 stores electric power and supplies electric power to each component of the measuring device 10 based on the control by the control unit 16.
  • the power supply unit 11 may be configured by, for example, a rechargeable battery such as a lithium ion secondary battery.
  • the power supply unit 11 may be configured by a primary battery such as a manganese dry battery or an alkaline manganese battery.
  • the sensor unit 12 acquires various information about the measuring device 10.
  • the sensor unit 12 includes the above-mentioned optical sensor 24 and temperature sensor 25.
  • the optical sensor 24 emits light from the light emitting unit 23 to the object to be measured through the measurement surface 21, and receives the reflected light from the object to be measured by the light receiving unit 22.
  • the temperature sensor 25 is arranged in the vicinity of the light emitting unit 23 and measures the temperature of the optical sensor 24 (particularly the light emitting unit 23).
  • the sensor unit 12 includes an input device including a button, a switch, and the like, which receives input of information from the user.
  • the notification unit 13 notifies the user of various information.
  • the notification unit 13 is composed of, for example, a light emitting device (for example, an LED) that emits light, a display device that displays information such as an image and text, a sound output device that outputs sound, a vibrating vibration device, and the like. For example, it is preferable to display the measurement result of the object to be measured measured by the measuring device 10 on the display device.
  • the storage unit 14 stores various information for the operation of the measuring device 10.
  • the various information includes the measurement data acquired by the optical sensor 24, the temperature data acquired by the temperature sensor 25, and the measurement results derived for the living tissue.
  • the storage unit 14 is composed of a non-volatile storage medium such as a flash memory. Further, the storage unit 14 stores a program such as firmware in addition to the computer-executable instructions for operating the measuring device 10.
  • the communication unit 15 is a communication interface capable of performing communication conforming to any wired or wireless communication standard.
  • a communication standard in the case of wireless communication, for example, Wi-Fi (registered trademark), Bluetooth (registered trademark), or the like can be adopted.
  • wired communication for example, a data communication cable is connected through an external connection terminal such as a micro USB. As a result, data related to the operation of the measuring device 10 is input / output to / from the external device.
  • the control unit 16 functions as an arithmetic processing unit and a control device, and controls the overall operation in the measuring device 10 according to various programs.
  • the control unit 16 is realized by, for example, an electronic circuit such as a CPU (Central Processing Unit) and a microprocessor.
  • the data processing unit 17 activates the sensor unit 12 including the optical sensor 24 and the temperature sensor 25 to acquire data, and derives a measurement result regarding a living tissue based on the acquired optical data and temperature.
  • the configuration example of the measuring device 10 has been described above.
  • the configuration of the measuring device 10 is not limited to the above, and various configurations exemplified below may be adopted.
  • the measuring device 10 for living tissue is miniaturized to fit in one hand of the user by using the optical sensor 24, and can be easily used by the user. Further, such a measuring device 10 improves the measurement accuracy of the substance amount of the living tissue by appropriately processing the optical data acquired by the optical sensor 24. Further, in such a measuring device 10, a measuring mechanism using the optical sensor 24 can be applied to a suction device such as a smoking tool.
  • FIG. 4 is a flow chart showing a measuring method for a living tissue according to the present embodiment, and shows a schematic operation flow regarding the operation of the measuring device 10.
  • the operation executed by the control unit 16 as the main body to derive the measurement result of the living tissue will be shown, but the operation of the measuring device 10 is not limited to this. That is, each step shown here is merely an example, and any other step may be included, and the operation order of each step is not limited unless otherwise specified below.
  • This operation flow starts when the power of the measuring device 10 is turned on and the measuring device 10 is started.
  • the temperature sensor 25 is activated.
  • the control unit 16 causes the temperature sensor 25 to measure the temperature of the optical sensor 24 (step S10).
  • the temperature of the optical sensor 24 includes at least the temperature of the light emitting unit 23. In addition to this, the temperature of the light receiving unit 22 may be included.
  • both the temperature of the light emitting unit 23 and the temperature of the light receiving unit 22 are acquired and thereafter. Good to use for processing.
  • the light receiving unit 22 and the light emitting unit 23 are arranged close to each other (for example, when they are arranged within 10 mm), it is assumed that the temperature of the light emitting unit 23 and the temperature of the light receiving unit 22 are the same. , The temperature of only the light emitting unit 23 may be used.
  • the control unit 16 determines whether the measured temperature of the temperature sensor 24 satisfies a predetermined temperature condition (step S20).
  • Predetermined temperature conditions may be defined, for example, using a predetermined temperature threshold (eg, 60 degrees Celsius (° C.)).
  • the temperature conditions are preset and stored in the storage unit 14. By providing a predetermined temperature condition, the operation of the optical sensor 24 is limited to a desired range.
  • the optical sensor 24 when the measured temperature of the optical sensor 24 satisfies a predetermined temperature condition, for example, when it is equal to or less than a predetermined temperature threshold (Yes), the optical sensor can be appropriately measured by the measuring device 10. 24 is activated (step S30). On the other hand, when the temperature of the optical sensor 24 does not satisfy the predetermined temperature condition and is higher than the predetermined temperature threshold value (No), the process returns to step S10 without activating the optical sensor 24. In particular, when the optical sensor 24 has already been activated, it is preferable to deactivate the optical sensor 24 (step S25).
  • the target to be activated and deactivated may be the entire optical sensor 24. Alternatively, the target may be only the light emitting unit 23 of the optical sensor 24, or both the light receiving unit 22 and the light emitting unit 23 of the optical sensor 24.
  • the measuring device 10 can be operated stably under appropriate temperature conditions, and the accuracy of measurement can be improved. Further, the battery of the power supply unit 11 can be saved.
  • control unit 16 causes the optical sensor 24 to measure the optical data of the object to be measured, which is a part of the biological tissue (step S40).
  • the measured optical data is associated with the temperature of the optical sensor 24 measured in step S10.
  • the optical data may include, for example, a plurality of wavelength data of light and light intensity for each wavelength.
  • the data processing unit 17 of the control unit 16 processes the optical data based on the measured temperature of the optical sensor 24 (step S50). More specifically, the data processing unit 17 specifies the optical data by selecting the optical data in which the temperature of the optical sensor 24 substantially corresponds to the designated temperature.
  • the designated temperature is a predetermined set value. Further, selecting optical data in which the temperature of the optical sensor 24 substantially corresponds to the designated temperature means that when the temperature of the light emitting unit 23 is within a certain designated temperature section, light is emitted from the measured optical data. It refers to selecting the optical data associated with the temperature of the unit 23.
  • the constant designated temperature section is a section having a lower limit value (48.0 ° C.) and an upper limit value (52.0 ° C.) of the temperature, for example, 50 ° C. ⁇ 2.0 ° C. .. Such information is preset and stored in the storage unit 14.
  • any method may be adopted as long as the optical data corresponding to the predetermined set value can be acquired.
  • the target optical data may be selectively acquired in real time at the timing when the temperature of the optical sensor 24 corresponds to the set value.
  • the target optical data is selectively stored, and the other optical data is deleted from the storage unit 14. It is also good.
  • the data processing unit 17 of the control unit 16 derives the measurement result regarding the object to be measured based on the optical data processed in step S50 (step S60). For example, the relative ratios of these are calculated using the two wavelength data contained in the optical data selected as substantially corresponding to the specified temperature. Then, it is preferable to specify the state at the time of measurement with respect to the reference state by comparing the calculated relative ratio with the reference state value calculated and determined in advance.
  • the measuring device 10 is used to measure the amount of water in the oral cavity of a person (that is, the amount of saliva).
  • the object to be measured is the human tongue.
  • the reflection ratio of the reflected light having wavelengths of 900 nm and 970 nm can be applied. That is, among the optical data processed in step S50, the light intensity data of the reflected light having wavelengths of 900 nm and 970 nm is selectively used to calculate the relative ratio.
  • the calculated relative ratio is the reflection ratio of the reflected light having wavelengths of 900 nm and 970 nm.
  • the light intensity of the reflected light with respect to the wavelengths of 900 nm and 970 nm can be acquired by the wavelength specifying unit included in the optical sensor 24.
  • the light intensity of reflected light having a wavelength of 900 nm and 970 nm is measured in advance, the reflection ratio is calculated, and the light intensity is stored in the storage unit 14. Keep it. Then, by comparing the reflection ratio measured by the measuring device 10 with the reflection ratio of the stored virtual dry tongue, it is possible to determine whether the tongue is in a normal state or in a dry state. In addition, a specific amount of saliva can be calculated. That is, by using the measuring device 10 for the living tissue according to the present embodiment, the amount of saliva in the oral cavity of a person can be easily measured.
  • the reflection ratio of the tongue in the normal state is uniform with respect to the reflection ratio of the virtual dry tongue. It was confirmed that the relative ratio was about 1.03 times and calculated as a significant difference.
  • control unit 16 causes the notification unit 13 to notify the measurement result derived in step S60 (step S70). For example, it is preferable to notify the user of the measurement result by displaying information such as an image on the display device.
  • the specific oral health condition such as the tongue being in a normal state or a dry state
  • the calculated saliva amount since the amount of saliva in the oral cavity of a person is also related to the amount of saliva in a person, the level of bad breath in a person may be further calculated from the calculated amount of saliva and notified to the user.
  • step S70 When the measurement result is notified in step S70, this operation flow ends.
  • optical data in which the temperature of the optical sensor 24 substantially corresponds to the designated temperature is selected. That is, since a desired one may be selected from a plurality of optical data, the calculation load applied to the control unit 16 can be small. Further, since such optical data is raw data, by using this, the accuracy of the finally obtained measurement result is higher than that of using the edited data.
  • Example of change in operation of measuring device (1-4-1) Example of change 1
  • the temperature conditions for the operation of the measuring device 10 are set in step S20. That is, the control unit 16 determines in step 20 whether the temperature of the temperature sensor 25 satisfies a predetermined temperature condition, and makes it possible to execute the processes after step S30 according to the result.
  • further temperature conditions for the operation of the measuring device 10 are set, and after the optical sensor 24 is activated in step S30, the operation of the measuring device 10 is further performed by the control unit 16. May be restricted.
  • FIG. 5 is a modification related to the schematic operation flow of FIG. 4, and is a schematic operation flow diagram in which further temperature conditions are added for the operation of the measuring device 10 between steps S30 and S70 of FIG. ..
  • the notification unit 13 notifies the activation of the optical sensor 24 in step S30 of FIG. For example, the LED is turned on to notify the user to that effect.
  • the optical sensor 24 When the optical sensor 24 is activated in step S30, the optical sensor 24 goes into a temperature rise stage as the light emitting unit 23 emits light.
  • the control unit 16 causes the temperature sensor 25 to detect that the optical sensor 24 has reached the first temperature (step S35).
  • the first temperature is the lower limit of the allowable temperature range that allows the measurement operation to be performed.
  • the temperature may be set to a temperature (for example, 20 ° C.) that can be reached within a few seconds after the optical sensor 24 is activated.
  • the first temperature may be the designated temperature used in steps S40 and S50 described above.
  • one designated temperature is set, but the temperature is not limited to this.
  • a plurality of designated temperatures may be set.
  • one designated temperature used at the time of measurement is dynamically determined from among the plurality of designated temperatures. For example, it is preferable to dynamically determine the temperature that is higher than the environmental temperature (for example, room temperature) at the time of starting the measuring device 10 and is closest to the environmental temperature as the designated temperature. It is advantageous to set a plurality of designated temperatures because more appropriate set values can be flexibly selected even when the measuring device 10 is used in an environment where the change in the environmental temperature is large. ..
  • the environmental temperature may be measured by the temperature sensor 25 before the optical sensor 24 is activated, or may be measured by a temperature sensor separately installed in a measuring device or the like.
  • control unit 16 sequentially executes the measurement operations of step S60 from the above-mentioned step S40 to derive the measurement result.
  • control unit 16 causes the temperature sensor 25 to detect that the optical sensor 24 has reached the second temperature (step S62).
  • the second temperature is a temperature higher than the first temperature, and is an upper limit value of an allowable temperature range that allows the measurement operation to be performed.
  • the control unit 16 determines that the temperature of the optical sensor 24 exceeds the allowable limit for the measurement operation, and deactivates the optical sensor 24 (step). S64). When the optical sensor 24 is deactivated, the control unit 16 may further notify the notification unit 13 to that effect. For example, it is preferable to turn off or blink the LED to notify the user that the measuring device 10 has exceeded the allowable limit.
  • the control unit 16 causes the temperature sensor 25 to detect that the optical sensor 24 has dropped to the third temperature (step S66).
  • the third temperature is a restart temperature for allowing the measurement operation to be performed again, and may be the same as the first temperature which is the lower limit of the allowable temperature range, or may be lower than the first temperature.
  • the control unit 16 may further notify the notification unit 13. to that effect. For example, it is preferable to turn on the LED that was turned off in step S64 again to notify the user that the measuring device 10 can restart the measurement.
  • step S68 the control unit 16 determines whether to end the measurement operation of the measuring device 10 (step S68). For example, it is preferable to determine whether or not an instruction from the user has been received through a button, a switch, or the like.
  • the measurement operation is terminated (Yes)
  • the process continues to step S70 in FIG. 3, the measurement result is displayed on the notification unit 13, and then the measurement operation is terminated.
  • the measurement operation is not completed (No)
  • the operation flow may return to, for example, step S30 in FIG.
  • the measuring device 10 by adding further temperature conditions for the operation of the measuring device 10, for example, it is possible to prevent the optical sensor 24 (particularly the light emitting unit 23) from overheating, and the safety of the measuring device 10 can be improved. Can be improved.
  • the measuring device 10 can be operated stably under appropriate temperature conditions, and the accuracy of measurement can be improved. Further, by appropriately deactivating the optical sensor 24, the battery of the power supply unit 11 can be saved.
  • FIG. 6 is a schematic graph of the temperature transition of the optical sensor 24 when the control unit 16 executes the temperature control operation.
  • the horizontal axis (x axis) is time (seconds)
  • the vertical axis (y axis) is the temperature (° C.) of the optical sensor 24.
  • the control unit 16 may, for example, measure the pulse of light with the optical sensor 24, carry out a known lock-in detection method using the pulse frequency, and execute the noise processing of the light.
  • the temperature of the optical sensor 24 can be maintained for about 8 seconds in the designated temperature interval (48 ° C to 52 ° C) with respect to the designated temperature of 50 ° C.
  • the measuring device 10 By executing such a temperature control operation, the measuring device 10 can be stabilized in a desired state. In addition, the accuracy of the measurement data can be improved. Further, the battery of the power supply unit 11 can be saved.
  • a model of the rate of change in light intensity with respect to the temperature of the optical sensor 24 is predetermined for each wavelength and stored in the storage unit 14.
  • the model of the rate of change in light intensity is created based on the experimental data obtained through the experiment.
  • FIG. 7 shows an example of such a model of the rate of change in light intensity.
  • the horizontal axis (x axis) is the temperature (° C.) of the optical sensor 24, and the vertical axis (y axis) is the relative emission intensity of the optical sensor 24.
  • the emission intensity is a relative emission intensity standardized so that the value is 1.0 when the temperature is 0 ° C.
  • the creation of a model of the rate of change in light intensity is not limited to this, and various models may be generated by machine learning using a huge number of data.
  • the optical data acquired by the optical sensor 24 may be corrected by using the model M of the rate of change of the light intensity.
  • the corrected light intensity I c1 ( ⁇ ) corrected based on the temperature of the optical sensor 24 is as follows. It is defined as the formula (1) of.
  • I c1 ( ⁇ ) I ( ⁇ ) / I ⁇ (t) (1)
  • I ( ⁇ ) is a measured value of the actual (before correction) light intensity with respect to the wavelength ⁇ measured by the optical sensor 24.
  • the heat generated by the operation of the light emitting unit 23 affects the optical data of the optical sensor 24.
  • the temperature of the light receiving unit 22 may also affect the optical data to be measured. Therefore, in this modification, in order to further improve the measurement accuracy of the measuring device 10, the optical data obtained by the light receiving unit 22 is corrected based not only on the temperature of the light emitting unit 23 but also on the temperature of the light receiving unit 22. Is good. In particular, when the light receiving unit 22 and the light emitting unit 23 are arranged apart from each other (for example, when they are separated by 10 mm or more), the optical data is based on both the temperature of the light emitting unit 23 and the temperature of the light receiving unit 22. It is better to correct.
  • the temperature of the light receiving unit 22 is t D
  • the temperature of the light emitting unit 23 is t S.
  • the intensity change rate of the light receiving unit 22 with respect to the temperature t D is I ⁇ D (t D )
  • the intensity change rate of the light emitting unit 23 with respect to the temperature t S is I ⁇ S (t S ).
  • the corrected light intensity I c2 ( ⁇ ) corrected based on both the temperature of the light receiving unit 22 and the temperature of the light emitting unit 23 is defined by the following mathematical formula (2).
  • I c2 ( ⁇ ) I ( ⁇ ) / (I ⁇ S (t S ) ⁇ I ⁇ D (t D )) (2)
  • the process related to the correction of the optical data in step S50 can be executed.
  • the process relating to the correction of the optical data in step S50 may be executed based on the mathematical formula (2).
  • the accuracy of the corrected light intensity is corrected by correcting the optical data.
  • the upper limit of such a temperature range may be set to the operation guarantee value of the light receiving unit 22 (for example, a spectroscope) and the light emitting unit 23 (for example, LED) instead of the above 60 ° C.
  • the measurement timing is not restricted by the temperature conditions of the optical sensor 24. That is, since the measuring device 10 can perform measurement at an arbitrary timing, the measuring device 10 becomes easier for the user to use. In particular, when the measuring device 10 is miniaturized and the user carries the measuring device 10, it is possible to perform measurement with stable and constant accuracy without being affected by the seasons and places where the temperature is various.
  • the method of correcting the optical data of this modification for each wavelength of the reflected light is the above-mentioned optical data in which the temperature of the optical sensor 24 substantially corresponds to the designated temperature. Can be performed together in combination with the method of selecting.
  • the measuring device 10 for a living tissue according to the first embodiment described above constitutes the measuring device 10 by itself.
  • the suction device 100 is provided with a measuring device 10 for living tissue. That is, the measuring device 10 for the living tissue according to the second embodiment is configured integrally with the suction device 100, with the object to be measured which is a part of the living tissue as the oral tissue.
  • the measuring device 10 is provided in the suction device 100 and is used as a part thereof.
  • the suction device 100 according to the present embodiment is miniaturized to the extent that it fits in one hand of the user, and the user can easily carry and use it. It can also be used as a measuring device 10 for oral tissue.
  • the suction device 100 is a device that generates a substance to be sucked by the user, and includes, but is not limited to, an electronic cigarette and a nebulizer. Further, the suction device 100 may be a heated flavor suction device or a non-heated flavor suction device, and may include various suction devices that generate an aerosol to be sucked by the user or an aerosol to which a flavor is imparted. In addition to aerosols, the generated suction component can also include invisible vapor-like gases.
  • FIG. 8 is a schematic view of a first configuration example of the suction device.
  • the suction device 100A includes a power supply unit 110, a cartridge 120, and a flavoring cartridge 130.
  • the power supply unit 110 includes a power supply unit 111A, a sensor unit 112A, a notification unit 113A, a storage unit 114A, a communication unit 115A, and a control unit 116A.
  • the cartridge 120 includes a heating unit 121A, a liquid guiding unit 122, and a liquid storage unit 123.
  • the flavoring cartridge 130 includes a flavor source 131 and a mouthpiece 124.
  • An air flow path 180 is formed in the cartridge 120 and the flavoring cartridge 130.
  • the power supply unit 111A, the sensor unit 112A, the notification unit 113A, the storage unit 114A, the communication unit 115A, and the control unit 116A included in the power supply unit 110 are the power supply unit 11 included in the measuring device 10 of the first embodiment.
  • Each configuration of the sensor unit 12, the notification unit 13, the storage unit 14, the communication unit 15, and the control unit 16 (data processing unit 17) is substantially included. The configuration that functions as a suction device will be described below.
  • the sensor unit 112A acquires various information about the suction device 100A.
  • the sensor unit 112A is composed of a pressure sensor such as a microphone capacitor, a flow rate sensor, a temperature sensor, or the like, and acquires a value associated with suction by the user.
  • the storage unit 114A stores various information for the operation of the suction device 100A. Further, the storage unit 114A stores a program such as firmware in addition to a computer-executable instruction for operating the suction device 100A.
  • the liquid storage unit 123 stores the aerosol source.
  • the atomization of the aerosol source produces an aerosol.
  • Aerosol sources are, for example, polyhydric alcohols such as glycerin and propylene glycol, and liquids such as water. Aerosol sources may contain tobacco-derived or non-tobacco-derived flavor components.
  • the suction device 100A is a medical inhaler such as a nebulizer
  • the aerosol source may include a drug.
  • the liquid guiding unit 122 guides and holds the aerosol source, which is the liquid stored in the liquid storage unit 123, from the liquid storage unit 123.
  • the liquid guiding portion 122 is a wick formed by twisting a fiber material such as glass fiber or a porous material such as a porous ceramic. In that case, the aerosol source stored in the liquid storage unit 123 is induced by the capillary effect of the wick.
  • the heating unit 121A heats the aerosol source to atomize the aerosol source and generate an aerosol.
  • the heating unit 121A is configured as a coil and is wound around the liquid induction unit 122.
  • the heating unit 121A generates heat, the aerosol source held in the liquid induction unit 122 is heated and atomized to generate an aerosol.
  • the heating unit 121A generates heat when power is supplied from the power supply unit 111A.
  • power may be supplied when the sensor unit 112A detects that the user has started suction and / or that predetermined information has been input. Then, when it is detected by the sensor unit 112A that the user has finished the suction and / or that the predetermined information has been input, the power supply may be stopped.
  • the flavor source 131 is a component for imparting a flavor component to the aerosol.
  • the flavor source 131 may contain a tobacco-derived or non-tobacco-derived flavor component.
  • the air flow path 180 is a flow path of air sucked by the user.
  • the air flow path 180 has a tubular structure having an air inflow hole 181 which is an inlet of air into the air flow path 180 and an air outflow hole 182 which is an outlet of air from the air flow path 180 at both ends.
  • the liquid guiding portion 122 is arranged on the upstream side (the side close to the air inflow hole 181), and the flavor source 131 is arranged on the downstream side (the side close to the air outflow hole 182).
  • the air flowing in from the air inflow hole 181 due to the suction by the user is mixed with the aerosol generated by the heating unit 121A, and is transported to the air outflow hole 182 through the flavor source 131 as shown by the arrow 190.
  • the flavor component contained in the flavor source 131 is imparted to the aerosol.
  • the mouthpiece 124 is a member that can be held by the user during suction.
  • An air outflow hole 182 is arranged in the mouthpiece 124. The user can take in the mixed fluid of aerosol and air into the oral cavity by holding and sucking the mouthpiece 124.
  • the configuration example 1 of the suction device 100A has been described above.
  • the configuration of the suction device 100A is not limited to the above, and various configurations exemplified below can be adopted.
  • the suction device 100A does not have to include the flavoring cartridge 130.
  • the cartridge 120 is provided with the mouthpiece 124.
  • the suction device 100A may include a plurality of types of aerosol sources.
  • a plurality of types of aerosols generated from a plurality of types of aerosol sources may be mixed in the air flow path 180 to cause a chemical reaction, whereby another type of aerosol may be produced.
  • the means for atomizing the aerosol source is not limited to heating by the heating unit 121A.
  • the means for atomizing the aerosol source may be oscillating atomization or induction heating.
  • FIG. 9 is a schematic view of a second configuration example of the suction device.
  • a stick-type base material 150 having a flavor-generating base material such as an aerosol source which is a suction component source and a filler containing a flavor source is inserted.
  • the aerosol source is not limited to a liquid, but may be a solid.
  • the inserted stick-type base material 150 is heated from its outer circumference to generate an aerosol containing a flavor.
  • the suction device 100B includes a power supply unit 111B, a sensor unit 112B, a notification unit 113B, a storage unit 114B, a communication unit 115B, a control unit 116B, a heating unit 121B, a holding unit 140, and a holding unit 140. Includes insulation 144.
  • Each of the power supply unit 111B, the sensor unit 112B, the notification unit 113B, the storage unit 114B, the communication unit 115B, and the control unit 116B functions substantially the same as the corresponding components included in the suction device 100A according to the first configuration example 1. do.
  • the holding portion 140 has an internal space 141, and holds the stick-type base material 150 while accommodating a part of the stick-type base material 150 in the internal space 141.
  • the holding portion 140 has an opening 142 that communicates the internal space 141 to the outside, and holds the stick-type base material 150 inserted into the internal space 141 from the opening 142.
  • the holding portion 140 is a tubular body having an opening 142 and a bottom portion 143 as a bottom surface, and defines a columnar internal space 141.
  • the holding portion 140 also has a function of defining an air flow path supplied to the stick-type base material 150.
  • An air inflow hole which is an inlet for air to such a flow path, is arranged, for example, at the bottom 143.
  • the air outflow hole which is an outlet for air from such a flow path, is an opening 142.
  • the stick-type base material 150 includes a base material portion 151 and a mouthpiece portion 152.
  • the base material portion 151 contains an aerosol source.
  • At least a part of the base material portion 151 is housed in the internal space 141, and at least a part of the mouthpiece portion 152 protrudes from the opening 142.
  • the heating unit 121B has the same configuration as the heating unit 121A according to the first configuration example. However, in the example shown in FIG. 9, the heating portion 121B is formed in a film shape and is arranged so as to cover the outer periphery of the holding portion 140. Then, when the heating unit 121B generates heat, the base material portion 151 of the stick-type base material 150 is heated from the outer periphery to generate an aerosol.
  • the heat insulating portion 144 prevents heat transfer from the heating portion 121B to other components.
  • the heat insulating portion 144 is made of a vacuum heat insulating material, an airgel heat insulating material, or the like.
  • the configuration example 2 of the suction device 100B has been described above.
  • the configuration of the suction device 100B is not limited to the above, and various configurations exemplified below can be adopted.
  • the heating portion 121B may be configured in a blade shape and may be arranged so as to project from the bottom portion 143 of the holding portion 140 to the internal space 141.
  • the blade-shaped heating portion 121B is inserted into the base material portion 151 of the stick-type base material 150, and the base material portion 151 of the stick-type base material 150 is heated from the inside.
  • the heating portion 121B may be arranged so as to cover the bottom portion 143 of the holding portion 140.
  • the heating unit 121B is a combination of two or more of a first heating unit that covers the outer periphery of the holding unit 140, a blade-shaped second heating unit, and a third heating unit that covers the bottom portion 143 of the holding unit 140. It may be configured as.
  • the holding portion 140 may include an opening / closing mechanism such as a hinge that opens / closes a part of the outer shell forming the internal space 141. Then, the holding portion 140 may sandwich the stick-type base material 150 inserted in the internal space 141 by opening and closing the outer shell.
  • the heating unit 121B may be provided at the holding portion of the holding unit 140 and may be heated while pressing the stick-type base material 150.
  • the means for atomizing the aerosol source is not limited to heating by the heating unit 121B.
  • the means for atomizing the aerosol source may be induction heating.
  • the suction device 100B may further include a heating unit 121A, a liquid induction unit 122, a liquid storage unit 123, and an air flow path 180 according to the first configuration, and the air outflow hole 182 of the air flow path 180 is inside. It may also serve as an air inflow hole to the space 141.
  • the mixed fluid of the aerosol and air generated by the heating unit 121A flows into the internal space 141, is further mixed with the aerosol generated by the heating unit 121B, and reaches the user's oral cavity.
  • FIG. 10 is a schematic view showing a schematic appearance of the suction device according to the present embodiment.
  • the suction device 100 includes a measuring device 10 for living tissue.
  • the suction device 100A according to the configuration example 1 shown in FIG. 8 will be described as an example, but the present invention is not limited to this, and the same applies to the suction device 100B according to the configuration example 2 shown in FIG.
  • the suction device 100A forms the outermost housing of the suction device 100A by assembling the power supply unit 110, the cartridge 120, the flavoring cartridge 130, and the mouthpiece shown in FIG.
  • the housing of the suction device 100A includes a hand-held portion 200 and a mouthpiece portion 210. The user can take in the mixed fluid of aerosol and air into the oral cavity by holding the mouthpiece portion 210 with one hand and sucking it from the Z-axis direction.
  • FIG. 11 is an example of the proximity type, and is a schematic enlarged view of the mouthpiece portion 210.
  • FIG. 12 is an example of a separated type. 11 and 12 mainly schematically show the arrangement relationship between the optical sensor 24 (light receiving unit 22 and light emitting unit 23) and the measurement surface 21.
  • a measuring surface 21 and a heat releasing portion 26 are provided on the surface of the suction device 210 of the suction device 100A, and an optical sensor 24 and a temperature sensor 25 are arranged inside the suction device 210.
  • the measurement surface 21 and the heat release unit 26 are provided on the side surface 210a of the mouthpiece portion 210, and an optical sensor 24 including the light receiving unit 22 and the light emitting unit 23 is arranged in the vicinity of the measurement surface 21.
  • the light receiving unit 22 and the light emitting unit 23 are arranged along the + Z direction so as to be parallel to the Z axis in the order of the light emitting unit 23 and the light receiving unit 22. Further, each element of the light receiving unit 22 and the light emitting unit 23 is directed in the + Y direction.
  • the temperature sensor 25 is arranged in the vicinity of the optical sensor 24 (particularly, the light emitting unit 23).
  • the measurement surface 21 should be provided with a measurement window in contact with the oral tissue to be measured.
  • the measurement window is preferably formed using a material that is highly safe for living tissues and has light transmission. For example, but not limited to this, acrylic resin, glass, or the like may be used.
  • the shape may be a film shape, a plate shape, or the like.
  • the area of the measurement window (that is, the area of the measurement surface 21 that comes into contact with the object to be measured) is preferably, for example, 300 mm 2 or less.
  • the measurement surface 21 is provided on the mouthpiece portion 210, the object to be measured may be an oral tissue, but the measurement surface 21 is not necessarily limited to this. That is, it may be widely applied to body surface skin and the like as well as oral tissues such as the tongue and lower lip.
  • the heat release unit 26 is arranged side by side along the side surface 210a.
  • the heat emitting unit 26 is preferably arranged adjacent to the light emitting unit 23 in order to release the heat generated by the light emitting unit 23 of the optical sensor 24 to the outside of the mouthpiece portion 210.
  • the heat release unit 26 is preferably composed of a heat conductive plate, and may be configured as a part of the measurement surface 21. As a result, the released heat can be conducted to the oral tissue, which is the object to be measured, and saliva secretion can be promoted.
  • the side surface 210a of the mouthpiece portion 210 forms a gradient surface (or a tapered surface) inclined by an angle ⁇ toward the light receiving portion 22 with respect to the Z direction.
  • the mouthpiece portion 210 has a tapered shape along the + Z direction.
  • the angle ⁇ should be adjusted in the range of 0 ° to 15 °. More preferably, the angle ⁇ is adjusted within the range of 1 ° to 5 ° (for example, 2 °).
  • the measurement surface 21 is preferably arranged at a position between the light receiving portion 22 and the light emitting portion 23 from the tip of the mouthpiece portion 210.
  • the light receiving unit 22 can be configured to receive the light emitted from the light emitting unit 23 and reflected from the object to be measured through the measurement surface 21.
  • the distance between the light receiving unit 22 and the light emitting unit 23 is preferably 3 mm to 20 mm. It is more preferable to adjust within the range of 5 mm to 15 mm.
  • the distance between the light emitting unit 23 and the measurement surface 21 may be 20 mm, more preferably 10 mm or less.
  • the temperature sensor 25 is preferably located near the light emitting unit 23 and at a position between the optical sensor 24 and the air flow path (dotted arrow) provided in the suction device 100A.
  • the heat of the aerosol may fluctuate the temperature of the optical sensor 24. .. Therefore, it is preferable to secure a distance between the optical sensor 24 and the air flow path, and further, it is preferable to arrange the temperature sensor 25 between them.
  • the sensor unit 12 including the optical sensor 24 and the temperature sensor 25 is arranged inside the suction port portion 210 of the suction device 100A.
  • other elements such as the control unit 16 are arranged inside the handheld portion 200 of the suction device 100A.
  • the sensor unit 12 and the control unit 16 are electrically wired by wires inside the suction device 100A.
  • the measurement surface 21 and the optical sensor 24 are arranged close to each other, and the heat emitting unit 26 and the temperature sensor 25 are also close to each other. It is arranged inside the mouthpiece portion 210. As a result, the influence of heat generation of the optical sensor 24 can be avoided, and the measuring device 10 can be provided even for a miniaturized device such as the suction device 100A.
  • an optical sensor 24 and a temperature sensor 25 are arranged inside the handheld portion 200 of the suction device 100A (note that the heat emitting portion 26 is not shown). Further, the suction port portion 210 of the suction device 100A is provided with a measurement surface 21.
  • the light receiving unit 22, the light emitting unit 23, and the measuring surface 21 are connected to each other through two optical fibers 27 (27A, 27B). That is, in the separated type arrangement example, by applying the optical fiber 27, the light receiving portion 22 and the light emitting portion 23 inside the handheld portion 200 can be separated from the measurement surface 21 inside the mouthpiece portion 210.
  • the separated type arrangement example is advantageous because the measurement surface 21 provided on the mouthpiece portion 210 side can be narrowed by applying the optical fiber 27.
  • the optical fiber 27 is not limited to this, but is preferably a quartz fiber. Quartz fibers are known to be mounted with a diameter of about 200 ⁇ m to 600 ⁇ m.
  • FIGS. 13 and 14 are plan views schematically showing the suction port portion 210 of the suction device 100A shown in FIG. 12 from the Z-axis direction
  • FIG. 14 is a plan view schematically showing the YY plane of the suction device 100A. It is a figure.
  • two optical fibers 27A and 27B are used. Then, as shown in FIG. 13, the end faces of the two optical fibers 27A and 27B form the measurement surface 21.
  • the distance between the end faces of the optical fibers 27A and 27B is preferably 0 ⁇ m to 20 mm. In particular, when measuring a substance on the surface of a living tissue such as the surface of the oral cavity, the distance between the end faces of the optical fibers 27A and 27B should be adjusted within the range of 0 ⁇ m to 3 mm.
  • the distance between the end faces of the optical fibers 27A and 27B is 0 when the end faces of the optical fibers 27A and 27B come into contact with each other. In this way, the accuracy of the measurement result can be improved by bringing the end faces of the optical fibers 27A and 27B close to each other or in contact with each other on the measurement surface 21.
  • the two optical fibers 27A and 27B are arranged so as to face each other at a predetermined angle with respect to the Z-axis direction. That is, it is preferable to arrange the optical sensors 24 (light receiving unit 22 and light emitting unit 23) so that the distance between the two optical fibers 27A and 27B is shortened toward the end faces of the optical fibers 27A and 27B.
  • the predetermined angle is preferably 10 ° or less.
  • the end face of the fiber is usually 90 ° with respect to the axial direction of the fiber, it may be inclined to 80 ° to 90 ° so that the sloped surfaces face each other. As a result, the light receiving unit 22 can receive the reflected light more effectively.
  • one optical fiber 27 that can be bifurcated may be used instead.
  • the end surface of the optical fiber 27 on the measurement surface 21 side is composed of one, while the opposite side is bifurcated and connected to the light receiving unit 22 and the light emitting unit 23, respectively.
  • the temperature sensor 25 is in the vicinity of the light emitting unit 23 and is between the optical sensor 24 and the air flow path (dotted arrow) provided in the suction device 100A. It should be placed in a position.
  • the heat of the aerosol may fluctuate the temperature of the optical sensor 24. .. Therefore, it is preferable to secure a distance between the optical sensor 24 and the air flow path and arrange the temperature sensor 25 between them.
  • the light receiving portion 22 and the light emitting portion 23 inside the handheld portion 200 and the measurement surface 21 inside the mouthpiece portion 210 are separated from each other through the optical fiber 27.
  • the mouthpiece portion 210 can be further miniaturized, and the measuring device 10 can be provided even for a miniaturized device such as the suction device 100A.
  • the control unit 16 executes the measurement operation (steps S40 to S60 in FIG. 4) only when the intensity of the light received by the light receiving unit 22 (particularly, the amount of light) is equal to or higher than a predetermined threshold value. It may be controlled to do so.
  • various information related to the user's suction operation can be used for measurement results as a suction device or associated with it. You may.
  • the measuring device 10 for a living tissue independently constitutes the measuring device 10. Further, in the second embodiment, the measuring device 10 for the living tissue is provided in the suction device 100 and integrally configured with the suction device 100. On the other hand, in the third embodiment, the measuring device 10 for the living tissue is configured to be detachably attached to the suction device 100.
  • the suction device 100A according to the configuration example 1 shown in FIG. 8 will be described as an example, but the present invention is not limited thereto.
  • a mechanism may be provided such that the measuring device 10 that can operate as a single unit is mechanically attached to the suction device 100A.
  • the measuring device 10 may be configured to perform the measurement at the same time.
  • the measuring device 10 may be configured to be electrically connected to the suction device 100A in response to the measuring device 10 being attached to the suction device 100A.
  • the power supply unit 111A of the suction device 100 may supply power to the measuring device 10 to operate the sensor unit 12 and the control unit 16.
  • the measuring device 10 may be configured to make various programs and / or setting information stored in the storage unit 114A of the suction device 100A available to the measuring device 10. Further, the measurement result may be notified by the notification unit 113A of the suction device 100A.
  • the measuring device 10 for a living tissue includes at least a sensor unit 13 and a measuring unit 21.
  • 15 and 16 are schematic views schematically showing a state in which such a measuring device 10 is attached to the suction device 100A.
  • the measuring device 10A of FIG. 15 is an example of a cap type device that can be attached to the tip of the suction portion 210 of the suction device 100A.
  • the cap type measuring device 10A may be configured as, for example, the adjacent type suction device 10A described in the second embodiment.
  • the measurement surface 21 is provided on the tapered surface, and the optical sensor 24 is arranged in the vicinity of the measurement surface. Further, the optical sensor 24 is preferably provided on the inner wall of the measuring device 10A.
  • the arrangement relationship between the measurement surface 21 and the optical sensor 24 is as described in the second embodiment. (The temperature sensor 25 and the heat release unit 26 are not shown here.)
  • the measuring device 10B of FIG. 16 is an example of a case-type device that can be attached so as to be penetrated by the tip of the suction portion 210 of the suction device 100A.
  • the case-type measuring device 10B may be configured as, for example, the discrete suction device 10A described in the second embodiment.
  • the optical sensor 24 and the optical fiber 27 are preferably provided on the inner wall of the measuring device 10A. Then, as shown in the figure, the optical fiber 27 wired from the optical sensor 24 is aligned so as to form the measurement surface 21 in contact with the suction portion 210 of the suction device 100A with the measurement device 10B attached. It should be done. (Similar to FIG. 15, the temperature sensor 25 and the heat release unit 26 are not shown here.)
  • the measuring devices 10A and 10B for the living tissue according to the present embodiment can be freely attached to and detached from the suction device 100A.
  • the suction device 100A may be made operable while the measuring devices 10A and 10B are attached to the suction device 100A.
  • the measuring devices 10A and 10B are sufficiently miniaturized devices, and the user can easily use the measuring device 10 together with the suction device 100A.
  • measuring devices, suction devices, and methods according to some embodiments have been described with reference to the drawings. It is understood that the present disclosure, when executed by a processor, can also be implemented as a program that causes the processor to execute a method of operating a measuring device or a suction device, or as a computer-readable storage medium containing the program. To.
  • Control unit, 120 ... Cartridge, 121A, 121B ... Heating unit, 122 ... Liquid induction unit, 123 ... Liquid storage unit, 124 ... Mouthpiece, 130 ... Flavoring cartridge, 131 ... Flavor source, 140 ... Holding unit, 141 ... Internal space, 142 ... Opening, 143 ... Bottom, 144 ... Insulation, 150 ... Stick-type base material, 151 ... Base material, 152 ... Mouthpiece, 180 ... Air flow path, 181 ... Air inflow hole, 182 ... Air Outflow hole, 200 ... handheld part, 210 ... mouthpiece part

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PCT/JP2020/041022 2020-11-02 2020-11-02 生体組織のための測定装置、吸引装置、生体組織のための測定方法、及びプログラム Ceased WO2022091403A1 (ja)

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PCT/JP2020/041022 WO2022091403A1 (ja) 2020-11-02 2020-11-02 生体組織のための測定装置、吸引装置、生体組織のための測定方法、及びプログラム
EP20959918.2A EP4238487A1 (en) 2020-11-02 2020-11-02 Measurement device for living tissue, suction device, measurement method for living tissue, and program
KR1020227040624A KR20230002917A (ko) 2020-11-02 2020-11-02 생체 조직을 위한 측정 장치, 흡인 장치, 생체 조직을 위한 측정 방법, 및 프로그램
JP2022558800A JP7453407B2 (ja) 2020-11-02 2020-11-02 生体組織のための測定装置、吸引装置、生体組織のための測定方法、及びプログラム
US18/071,374 US12023125B2 (en) 2020-11-02 2022-11-29 Measurement device for living tissue, suction device, measurement method for living tissue, and program

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