WO2022084888A1 - Articles médicaux emballés à emballage réduit - Google Patents

Articles médicaux emballés à emballage réduit Download PDF

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Publication number
WO2022084888A1
WO2022084888A1 PCT/IB2021/059684 IB2021059684W WO2022084888A1 WO 2022084888 A1 WO2022084888 A1 WO 2022084888A1 IB 2021059684 W IB2021059684 W IB 2021059684W WO 2022084888 A1 WO2022084888 A1 WO 2022084888A1
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WO
WIPO (PCT)
Prior art keywords
article
adhesive
medical article
packaged
segment
Prior art date
Application number
PCT/IB2021/059684
Other languages
English (en)
Inventor
Audrey A. Sherman
Christoph T. R. SCHUELL
Jess W. SMITH
Hironobu Ishiwatari
Original Assignee
3M Innovative Properties Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Company filed Critical 3M Innovative Properties Company
Priority to US18/031,519 priority Critical patent/US20230372158A1/en
Publication of WO2022084888A1 publication Critical patent/WO2022084888A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A61F13/00072—Packaging of dressings
    • A61F13/00076—Packaging of adhesive dressings
    • A61F13/0008—Packaging of adhesive dressings having means for facilitating the removal of the packaging and release liner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A61F13/00072—Packaging of dressings
    • A61F13/00076—Packaging of adhesive dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
    • A61F13/0253—Adhesive bandages or dressings characterised by the skin-adhering layer characterized by the adhesive material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0259—Adhesive bandages or dressings characterised by the release liner covering the skin adhering layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/12—Bandages or dressings; Absorbent pads specially adapted for the head or neck
    • A61F13/122—Bandages or dressings; Absorbent pads specially adapted for the head or neck specially adapted for the face
    • A61F13/124—Bandages or dressings; Absorbent pads specially adapted for the head or neck specially adapted for the face specially adapted for the eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/04—Eye-masks ; Devices to be worn on the face, not intended for looking through; Eye-pads for sunbathing
    • A61F9/045—Eye-shades or visors; Shields beside, between or below the eyes

Definitions

  • the current disclosure relates to medical articles contained within a package, where the medical article is folded to reduce the size of the package required to contain it.
  • a wide variety of medical articles are placed within packages to keep them sterile, clean, secure, and easier to handle.
  • Examples of medical articles include dressings, bandages, and the like.
  • a dressing is a sterile pad or compress applied to a wound to promote healing and protect the wound from further harm.
  • a dressing is designed to be in direct contact with the wound.
  • Many modem dressings are self-adhesive.
  • Bandages are a piece of material to support a medical apparatus, such as wound dressings, or on its own, to administer support to the body. Bandages, additionally, can be used to inhibit bodily fluids from flowing, such as blood, lymph fluid, and more.
  • a wide variety of medical articles are placed within packages to keep them sterile, clean, secure, and easier to handle.
  • the medical article is typically removed from the package, and often the packaging is discarded.
  • the current disclosure relates to medical articles contained within a package, where the medical article has a reduced size to reduce the size of the package required to contain it. Also disclosed are methods of using the medical articles.
  • the packaged medical article comprises a package enclosing a medical article and a medical article contained within the package.
  • the medical article comprises an adhesive article, where the adhesive article comprises at least one fold along a fold line along an axis of symmetry of the adhesive article.
  • the packaged medical article comprises a package enclosing a medical article and a medical article contained within the package where the medical article comprises an adhesive article comprising at least three segments.
  • the first segment comprises a first adhesive layer
  • the second segment, adjacent to the first segment comprises a non-adhesive layer
  • the third segment, adjacent to the second segment comprises a second adhesive layer.
  • the adhesive article also has one fold along a fold line along an axis of symmetry of the adhesive article, where the fold line is located in the second segment.
  • the adhesive article also has a double-sided release liner with a first release surface and a second release surface, where the first release surface is in contact with adhesive layer of the first segment, and the second release surface is in contact with the adhesive layer of the second segment.
  • the packaged medical article comprises a package enclosing a medical article and a medical article contained within the package.
  • the medical article comprises a double-sided release liner with a first release surface with a first release coating and a second release surface with a second release coating, where the first and second release coatings may be the same or different, a first adhesive article attached to the first release surface of the double-sided release liner, and a second adhesive article attached to the second release surface of the double-sided release liner.
  • the method comprises preparing a packaged medical article, opening the package, removing the medical article from the package, unfolding the medical article, and applying the medical article to mammalian skin.
  • the packaged medical article comprises a medical article as described above.
  • Figure 1 is atop view of an adhesive medical article of this disclosure.
  • Figure 2 is a cross-sectional view of another adhesive medical article of this disclosure.
  • Figure 3 is atop view of another adhesive medical article of this disclosure.
  • Figure 4 is a top view of an eye patch article of this disclosure.
  • Figure 5 is a cross-sectional view of another adhesive medical article of this disclosure.
  • Figure 6 is a cross-sectional view of another eye patch article of this disclosure.
  • FIG. 7 is a cross-sectional view of another adhesive medical article of this disclosure.
  • FIG. 7 is a cross-sectional view of another adhesive medical article of this disclosure.
  • a wide variety of medical articles are placed within packages to keep them sterile, clean, secure, and easier to handle.
  • medical articles include dressings, bandages, and eye patches.
  • a dressing is a sterile pad or compress applied to a wound to promote healing and protect the wound from further harm.
  • a dressing is designed to be in direct contact with the wound.
  • Many modem dressings are self-adhesive.
  • Bandages are a piece of material to support a medical apparatus, such as wound dressings, or on its own, to administer support to the body. Bandages, additionally, can be used to inhibit bodily fluids from flowing, such as blood, lymph fluid, and more.
  • eyepatch is used to describe all medical eye coverings including eyepatches and eyepads.
  • An eyepatch is a small patch that is worn in front of one eye.
  • An eyepad or eye pad is a soft medical dressing that can be applied over an eye to protect it, keep it closed, or protect it from entering light.
  • Eyepatches may be made of cloth or a polymeric material. Eyepatches are often worn by people to cover a lost or injured eye, but they also have a therapeutic use in children for the treatment of amblyopia.
  • the medical article When the medical article is desired to be used, it is typically removed from the package, and often the packaging is discarded. This produces waste that needs to be disposed of. If the packaging comes in contact with bodily fluids, the waste becomes medical waste which often has special handling requirements.
  • the medical articles have reduced packaging.
  • the medical articles are folded along a fold line along an axis of symmetry of the medical article to decrease the size of the package and the amount of packaging material needed to make the package.
  • double-sided release liners are used to reduce the size of the package. It has been discovered that a wide range of medical articles can be folded, unpackaged, and used with no ill effects to the medical article.
  • adheresive refers to polymeric compositions useful to adhere together two adherends. Examples of adhesives are non-tacky adhesives (i.e., cold-seal adhesives), heat activated adhesives, pressure sensitive adhesives, curable adhesives, and gel adhesives.
  • Non-tacky adhesives have limited or low tack to most substrates but can have acceptable adhesive strength when paired with specific target substrates or when two layers of the non-tacky adhesives are contacted.
  • the non-tacky adhesive adheres by affinity.
  • Heat activated adhesives are non-tacky at room temperature but become tacky and capable of bonding to a substrate at elevated temperatures. These adhesives usually have a Tg or melting point (Tm) above room temperature. When the temperature is elevated above the Tg or Tm, the storage modulus usually decreases and the adhesive become tacky.
  • PSA compositions are well known to those of ordinary skill in the art to possess properties including the following: (1) aggressive and permanent tack, (2) adherence with no more than finger pressure, (3) sufficient ability to hold onto an adherend, and (4) sufficient cohesive strength to be cleanly removable from the adherend.
  • Materials that have been found to function well as PSAs are polymers designed and formulated to exhibit the requisite viscoelastic properties resulting in a desired balance of tack, peel adhesion, and shear holding power. Obtaining the proper balance of properties is not a simple process.
  • Curable adhesives are reactive compositions that upon activation or mixing begin to react and form an adhesive bond.
  • Examples of curable adhesives include anaerobic adhesives such as cyanoacrylates that polymerize and form bonds upon exposure to oxygen, as well as 2-part adhesives where the 2 parts are mixed and react.
  • Hot melt adhesives are thermoplastic materials that are solid and non-tacky at room temperature but upon heating melt and flow. The hot melt adhesive is applied in the molten state and forms a bond upon cooling to a solid state.
  • gel adhesive refers to a tacky semi-solid crosslinked matrix containing a liquid or a fluid that is capable of adhering to one or more substrates.
  • the gel adhesives may have some properties in common with pressure sensitive adhesives, but they are not pressure sensitive adhesives.
  • “Hydrogel adhesives” are gel adhesives that have water as the fluid contained within the crosslinked matrix.
  • (meth)acrylate refers to monomeric acrylic or methacrylic esters of alcohols. Acrylate and methacrylate monomers or oligomers are referred to collectively herein as “(meth)acrylates”. Materials referred to as “(meth)acrylate functional” are materials that contain one or more (meth)acrylate groups.
  • silicone-based refers to polymers or units of polymers that contain siloxane units.
  • silicone or siloxane are used interchangeably and refer to units with dialkyl or diaryl siloxane (-SiR2O-) repeating units.
  • room temperature and “ambient temperature” are used interchangeably to mean temperatures in the range of 20°C to 25°C.
  • Tg glass transition temperature
  • DSC Differential Scanning Calorimetry
  • adjacent as used herein when referring to two layers means that the two layers are in proximity with one another with no intervening open space between them. They may be in direct contact with one another (e.g. laminated together) or there may be intervening layers.
  • polymer and “macromolecule” are used herein consistent with their common usage in chemistry. Polymers and macromolecules are composed of many repeated subunits. As used herein, the term “macromolecule” is used to describe a group attached to a monomer that has multiple repeating units. The term “polymer” is used to describe the resultant material formed from a polymerization reaction.
  • alkyl refers to a monovalent group that is a radical of an alkane, which is a saturated hydrocarbon.
  • the alkyl can be linear, branched, cyclic, or combinations thereof and typically has 1 to 20 carbon atoms. In some embodiments, the alkyl group contains 1 to 18, 1 to 12, 1 to 10, 1 to 8, 1 to 6, or 1 to 4 carbon atoms.
  • alkyl groups include, but are not limited to, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, n- pentyl, n-hexyl, cyclohexyl, n-heptyl, n-octyl, and ethylhexyl.
  • aryl refers to a monovalent group that is aromatic and carbocyclic.
  • the aryl can have one to five rings that are connected to or fused to the aromatic ring.
  • the other ring structures can be aromatic, non-aromatic, or combinations thereof.
  • Examples of aryl groups include, but are not limited to, phenyl, biphenyl, terphenyl, anthryl, naphthyl, acenaphthyl, anthraquinonyl, phenanthryl, anthracenyl, pyrenyl, perylenyl, and fluorenyl.
  • free radically polymerizable and “ethylenically unsaturated” are used interchangeably and refer to a reactive group which contains a carbon-carbon double bond which is able to be polymerized via a free radical polymerization mechanism.
  • optically transparent refers to an article, fdm or adhesive that has a high light transmittance over at least a portion of the visible light spectrum (about 400 to about 700 nm).
  • optically transparent articles have a visible light transmittance of at least 80% and a haze of less than 10%.
  • optical clear refers to an adhesive or article that has a high light transmittance of at least 90% over at least a portion of the visible light spectrum (about 400 to about 700 nm), and that exhibits low haze, typically less than about 5%, or even less than about 2%.
  • the packaged articles comprise a package enclosing a medical article, and a medical article contained within the package.
  • the medical article comprises an adhesive article, where the adhesive article comprises at least one fold along a fold line along an axis of symmetry of the adhesive article.
  • Other packaged articles of this disclosure comprise a double-sided release liner to reduce the size of the article to be packaged.
  • the adhesive articles are folded and adhered to the double-sided release liner, in other embodiments two adhesive articles are adhered to the opposite sides of the double-sided release liner.
  • packages are suitable for use in the packaged articles of the present disclosure.
  • Packages as used herein are containers having a first substrate layer and a second substrate layer where the entire perimeter of contact between the first substrate layer and second substrate layer is sealed to give a discrete sealed unit.
  • first and second substrate layers A wide variety of materials can be used in the first and second substrate layers.
  • the first and second substrate layers may be the same or they may be different.
  • suitable substrates include paper, polymer-coated paper, nonwovens, polymeric films and metal foils.
  • suitable metal foils include aluminum foil.
  • polymeric films include films comprising one or more polymers such as cellulose acetate butyrate; cellulose acetate propionate; cellulose triacetate; poly (meth)acry late s such as polymethyl methacrylate; polyesters such as polyethylene terephthalate, and polyethylene naphthalate; copolymers or blends based on naphthalene dicarboxylic acids; polyether sulfones; polyurethanes; polycarbonates; polyvinyl chloride; syndiotactic polystyrene; cyclic olefin copolymers; and polyolefins including polyethylene and polypropylene such as cast and biaxially oriented polypropylene.
  • the substrate may comprise single or multiple layers, such as polyethylene-coated polyethylene terephthalate.
  • the substrate may be primed or treated to impart some desired property to one or more of its surfaces. Examples of such treatments include corona, flame, plasma and chemical treatments.
  • the two substrates can be sealed in a wide variety of ways, depending upon the materials comprising the substrates as well as the desired use for the packaged article.
  • the packages can be sealed by melt sealing by the use of heat and pressure.
  • the packages are adhesively sealed.
  • a wide variety of adhesives are suitable including non-tacky adhesives (i.e., cold-seal adhesives), heat activated adhesives, pressure sensitive adhesives, cured adhesives, and hot melt adhesives.
  • Non-tacky adhesives have limited or low tack to most substrates but can have acceptable adhesive strength when paired with specific target substrates or when two layers of the non-tacky adhesives are contacted.
  • the non-tacky adhesive adheres by affinity.
  • Heat activated adhesives are non-tacky at room temperature but become tacky and capable of bonding to a substrate at elevated temperatures. These adhesives usually have a Tg or melting point (Tm) above room temperature. When the temperature is elevated above the Tg or Tm, the storage modulus usually decreases and the adhesive become tacky.
  • PSA compositions are well known to those of ordinary skill in the art to possess properties including the following: (1) aggressive and permanent tack, (2) adherence with no more than finger pressure, (3) sufficient ability to hold onto an adherend, and (4) sufficient cohesive strength to be cleanly removable from the adherend.
  • Materials that have been found to function well as PSAs are polymers designed and formulated to exhibit the requisite viscoelastic properties resulting in a desired balance of tack, peel adhesion, and shear holding power. Obtaining the proper balance of properties is not a simple process.
  • Curable adhesives are reactive compositions that upon activation or mixing begin to react and form an adhesive bond.
  • curable adhesives include anaerobic adhesives such as cyanoacrylates that polymerize and form bonds upon exposure to oxygen, as well as 2-part adhesives where the 2 parts are mixed and react.
  • 2-part adhesives include epoxy and urethane adhesives.
  • Two-part epoxy adhesives have epoxy resins in one part and epoxy curatives in the second part.
  • Hot melt adhesives are thermoplastic materials that are solid and non-tacky at room temperature but upon heating melt and flow. The hot melt adhesive is applied in the molten state and forms a bond upon cooling to a solid state.
  • the choice of method of sealing depends upon a variety of factors, including the needs to environment exposure conditions that the package is to be exposed (such a humidity, heat, etc.), the length of time the package needs to remain sealed, and the desired ease of opening of the package.
  • the adhesive article is a planar article.
  • Planar articles are those that are defined by two primary dimensions a length and a width. Mathematically, these dimensions can be defined by axes, with the length being the x axis and the width being the y axis.
  • the articles are in fact three dimensional objects and have a third dimension, which is the thickness and mathematically is defined as the z axis.
  • the articles are not necessarily in the shape of a regular polygon, i.e. the article may not be in the shape of a square or rectangle for example.
  • the sides of the article may be curved or angled.
  • the articles can have a variety of axes of symmetry. These axes of symmetry can be along the x axis, along the y axis, or can form a variety of angles from the x axis or y axis.
  • the planar adhesive article has a length (x axis) and a width (y axis) and the one fold along a fold line along an axis of symmetry comprises a fold along the y axis.
  • the folded article has half the length of the unfolded article. This decrease in length is achieved by a doubling of the thickness of the article.
  • the thickness of the article is so much less than the length of the article, and since the substrates of the package are flexible, this doubling of thickness does not require a significant change of the thickness of the package.
  • the package can be half the length and substantially the same thickness as the package that contains the same article in an unfolded state.
  • the planar article has a length (x axis) and a width (y axis) and the one fold along a fold line along an axis of symmetry comprises a fold along the x axis.
  • the folded article has half the width of the unfolded article. This decrease in width is achieved by a doubling of the thickness of the article.
  • the thickness of the article is so much less than the width of the article, and since the substrates of the package are flexible, this doubling of thickness does not require a significant change of the thickness of the package.
  • the package can be half the width and substantially the same thickness as the package that contains the same article in an unfolded state.
  • wound dressings comprise a backing layer, an adhesive layer that may be continuous or discontinuous, and optionally may include an absorbent pad.
  • the backing layer is rigid enough to provide stability to the adhesive article but remains flexible.
  • suitable tape backings include breathable conformable backing, on which the adhesive layer is disposed.
  • a wide range of breathable conformable backings are suitable for use in articles of this disclosure.
  • breathable conformable backing include woven or knit textiles, nonwovens, or a polymeric films.
  • the breathable conformable backing comprises a high moisture vapor permeable film backing.
  • a high moisture vapor permeable film backing examples of such backings, methods of making such films, and methods for testing their permeability are described, for example, in US Patent Nos. 3,645,835 and 4,595,001.
  • backings are porous materials.
  • the backing is conformable to anatomical surfaces. As such, when the backing is applied to an anatomical surface, it conforms to the surface even when the surface is moved. Generally, the backing is also conformable to animal anatomical joints. When the joint is flexed and then returned to its unflexed position, the backing stretches to accommodate the flexion of the joint, but is resilient enough to continue to conform to the joint when the joint is returned to its unflexed condition.
  • the backing layer is transparent (and used in conjunction with a transparent adhesive) to prepare a transparent dressing.
  • Transparent dressings are most commonly used when a doctor wants to closely monitor healing of a specific wound. Since transparent dressings are made using a clear film, it’s much easier to monitor wounds using this type of dressing in compared to a cloth or foam bandage. For this reason, transparent dressings are often used on larger, more complicated wounds.
  • the substrate layer has a wide range of thicknesses. In some embodiments, the thickness is at least 10 micrometers, up to 152 micrometers (6 mils), and in some embodiments the thickness will be from 25 micrometers (1 mil) up to 102 micrometers (4 mils) thick. A wide range of intermediate thicknesses are also suitable.
  • the adhesive layer comprises a pressure sensitive adhesive or a gel adhesive.
  • suitable pressure sensitive adhesives are (meth)acrylate pressure sensitive adhesives, siloxane pressure sensitive adhesives, and block copolymer pressure sensitive adhesives.
  • the pressure sensitive adhesive may contain a single polymeric material or may contain a blend of polymeric materials.
  • the pressure sensitive adhesive may be a crosslinked pressure sensitive adhesive.
  • suitable gel adhesives are siloxane gel adhesives which comprise a crosslinked siloxane matrix and a fluid, typically a siloxane fluid. Each of these adhesives is described in detail below.
  • the adhesive is a (meth)acrylate-based pressure sensitive adhesive.
  • Particularly suitable (meth)acrylate-based pressure sensitive adhesives include copolymers derived from: (A) at least one monoethylenically unsaturated alkyl (meth) acrylate monomer (i.e., alkyl acrylate and alkyl methacrylate monomer); and (B) at least one monoethylenically unsaturated free -radically copolymerizable reinforcing monomer.
  • the reinforcing monomer has a homopolymer glass transition temperature (Tg) higher than that of the alkyl (meth)acrylate monomer and is one that increases the glass transition temperature and cohesive strength of the resultant copolymer.
  • Tg homopolymer glass transition temperature
  • copolymer refers to polymers containing two or more different monomers, including terpolymers, tetrapolymers, etc.
  • Monomer A which is a monoethylenically unsaturated alkyl acrylate or methacrylate (i.e., (meth)acrylic acid ester), contributes to the flexibility and tack of the copolymer.
  • monomer A has a homopolymer Tg of no greater than about 0°C.
  • the alkyl group of the (meth)acrylate has an average of about 4 to about 20 carbon atoms, or an average of about 4 to about 14 carbon atoms.
  • the alkyl group can optionally contain oxygen atoms in the chain thereby forming ethers or alkoxy ethers, for example.
  • Examples of monomer A include, but are not limited to, 2-methylbutyl acrylate, isooctyl acrylate, lauryl acrylate, 4- methyl-2 -pentyl acrylate, isoamyl acrylate, sec-butyl acrylate, n-butyl acrylate, n- hexyl acrylate, 2-ethylhexyl acrylate, n-octyl acrylate, n-decyl acrylate, isodecyl acrylate, isodecyl methacrylate, and isononyl acrylate.
  • Suitable monoethylenically unsaturated (meth)acrylates that can be used as monomer A include isooctyl acrylate, 2 -ethyl -hexyl acrylate, and n- butyl acrylate. Combinations of various monomers categorized as an A monomer can be used to make the copolymer.
  • Monomer B which is a monoethylenically unsaturated free- radically copolymerizable reinforcing monomer, increases the glass transition temperature and cohesive strength of the copolymer.
  • monomer B has a homopolymer Tg of at least about 10°C.
  • monomer B is a reinforcing (meth)acrylic monomer, including an acrylic acid, a methacrylic acid, an acrylamide, or a (meth)acrylate.
  • Examples of monomer B include, but are not limited to, acrylamides, such as acrylamide, methacrylamide, N-methyl acrylamide, N-ethyl acrylamide, N- hydroxyethyl acrylamide, diacetone acrylamide, N,N- dimethyl acrylamide, N, N-diethyl acrylamide, N-ethyl-N-aminoethyl acrylamide, N-ethyl-N- hydroxyethyl acrylamide, N,N -dihydroxy ethyl acrylamide, t-butyl acrylamide, N,N- dimethylaminoethyl acrylamide, and N-octyl acrylamide.
  • acrylamides such as acrylamide, methacrylamide, N-methyl acrylamide, N-ethyl acrylamide, N- hydroxyethyl acrylamide, diacetone acrylamide, N,N- dimethyl acrylamide, N, N-diethyl
  • monomer B examples include itaconic acid, crotonic acid, maleic acid, fumaric acid, 2,2-(diethoxy)ethyl acrylate, 2- hydroxyethyl acrylate or methacrylate, 3 -hydroxypropyl acrylate or methacrylate, methyl methacrylate, isobomyl acrylate, 2-(phenoxy)ethyl acrylate or methacrylate, biphenylyl acrylate, t-butylphenyl acrylate, cyclohexyl acrylate, dimethyladamantyl acrylate, 2-naphthyl acrylate, phenyl acrylate, N-vinyl formamide, N-vinyl acetamide, N-vinyl pyrrolidone, and N-vinyl caprolactam.
  • Particularly suitable reinforcing acrylic monomers that can be used as monomer B include acrylic acid and acrylamide. Combinations of various reinforcing monoethylenically unsaturated monomers categorized as a B monomer can be used to make the copolymer.
  • the (meth)acrylate copolymer is formulated to have a resultant Tg of less than about 0°C and more typically, less than about -10°C.
  • Such (meth)acrylate copolymers generally include about 60 parts to about 98 parts per hundred of at least one monomer A and about 2 parts to about 40 parts per hundred of at least one monomer B.
  • the (meth)acrylate copolymers have about 85 parts to about 98 parts per hundred or at least one monomer A and about 2 parts to about 15 parts of at least one monomer B.
  • the adhesive comprises a siloxane pressure sensitive adhesive.
  • siloxane pressure sensitive adhesives are suitable, and typically are referred to as siloxane-based, as the pressure sensitive adhesives may contain additional groups besides siloxane units.
  • the siloxane-based pressure sensitive adhesive compositions comprise at least one siloxane-based elastomeric polymer and typically include tackifying resins.
  • suitable siloxane-based elastomeric polymers include for example, urea- containing siloxane copolymers, oxamide -containing siloxane copolymers, amide-containing siloxane copolymers, urethane-containing siloxane copolymers, and mixtures thereof.
  • Siloxane-based pressure sensitive adhesives are different from the siloxane gel adhesives described below since pressure sensitive adhesives and gel adhesives are different classes of materials.
  • Useful silicone polyurea block copolymers are disclosed in, e.g., U.S. Patent Nos. 5,512,650, 5,214,119, 5,461,134, and 7,153,924 and PCT Publication Nos. WO 96/35458, WO 98/17726, WO 96/34028, WO 96/34030 and WO 97/40103.
  • silicone elastomeric polymers are oxamide -containing polymers such as polydiorganosiloxane polyoxamide block copolymers.
  • polydiorganosiloxane polyoxamide block copolymers are presented, for example, in US Patent Publication No. 2007-0148475.
  • amide-based silicone polymers Another useful class of silicone elastomeric polymers is amide-based silicone polymers. Such polymers are similar to the urea-based polymers, containing amide linkages (-N(D)-C(O)-) instead of urea linkages (-N(D)-C(O)-N(D)-), where C(O) represents a carbonyl group and D is a hydrogen or alkyl group.
  • Such polymers may be prepared in a variety of different ways.
  • the amide-based polymer can be prepared by reaction with a poly-carboxylic acid or a poly-carboxylic acid derivative such as, for example di-esters.
  • an amide-based silicone elastomer is prepared by the reaction of a polydiorganosiloxane diamine and di-methyl salicylate of adipic acid.
  • Silicone polyurea-urethane block copolymers include the reaction product of a polydiorganosiloxane diamine (also referred to as silicone diamine), a diisocyanate, and an organic polyol.
  • a polydiorganosiloxane diamine also referred to as silicone diamine
  • a diisocyanate also referred to as silicone diamine
  • organic polyol such materials are structurally very similar to the structure of Formula I except that the -N(D)-B-N(D)- links are replaced by -O-B-O- links. Examples are such polymers are presented, for example, in US Patent No. 5,214,119.
  • the siloxane block copolymer adhesives typically include a siloxane tackifying resin.
  • Siloxane tackifying resins have in the past been referred to as “silicate” tackifying resins, but that nomenclature has been replaced with the term “siloxane tackifying resin”.
  • the siloxane tackifying resins are added in sufficient quantity to achieve the desired tackiness and level of adhesion. In some embodiments, a plurality of siloxane tackifying resins can be used to achieve desired performance.
  • Suitable siloxane tackifying resins include MQ siloxane tackifying resins. Suitable siloxane tackifying resins are commercially available from sources such as Dow Coming (e.g., DC 2-7066), Momentive Performance Materials (e.g., SR545 and SR1000), and Wacker Chemie AG (e.g., BELSIL TMS-803).
  • Dow Coming e.g., DC 2-7066
  • Momentive Performance Materials e.g., SR545 and SR1000
  • Wacker Chemie AG e.g., BELSIL TMS-803
  • the adhesive comprises a block copolymer pressure sensitive adhesive that are not siloxane-based like the polymers described above.
  • suitable block copolymers comprise polyurethane block copolymers, polyurea block copolymers, or hydrocarbon block copolymers.
  • Suitable polyurethane block copolymers and polyurea block copolymers include the non-siloxane polymers described in US Patent No. 9,738,818.
  • block copolymer pressure sensitive adhesives is hydrocarbon-based block copolymer pressure sensitive adhesives.
  • suitable hydrocarbon-based block copolymer pressure sensitive adhesives are styrene block copolymer pressure sensitive adhesives and (meth)acrylate block copolymer pressure sensitive adhesives.
  • Styrene block copolymer pressure sensitive adhesives generally comprise elastomers of the A-B or A-B-A type, where A represents a thermoplastic polystyrene block and B represents a rubbery block of polyisoprene, polybutadiene, or poly(ethylene/butylene), and resins.
  • block copolymers useful in block copolymer pressure sensitive adhesives include linear, radial, star and tapered styrene-isoprene block copolymers such as “KRATON D1107P”, available from KRATON Corp., and “EUROPRENE SOL TE 9110”, available from EniChem Elastomers Americas, Inc.; linear styrene-(ethylene- butylene) block copolymers such as “KRATON G1657”, available from KRATON Corp.; linear styrene-(ethylene-propylene) block copolymers such as “KRATON G1750X”, available from KRATON Corp.; and linear, radial, and star styrene-butadiene block copolymers such as “KRATON D1118X”, available from KRATON Corp., and “EUROPRENE SOL TE 6205”, available from EniChem Elastomers Americas, Inc.
  • the polystyrene blocks tend to
  • the (meth)acrylate-based block pressure sensitive adhesives include copolymers that are the reaction product of at least two A block polymeric units and at least one B block polymeric unit (i.e., at least two A block polymeric units are covalently bonded to at least one B block polymeric unit).
  • Each A block which has a Tg of at least 50°C, is the reaction product of a first monomer composition that contains an alkyl methacrylate, an aralkyl methacrylate, an aryl methacrylate, or a combination thereof.
  • the B block which has a Tg no greater than 20°C, is the reaction product of a second monomer composition that contains an alkyl(meth)acrylate, a heteroalkyl(meth)acrylate, a vinyl ester, or a combination thereof.
  • the block copolymer contains 20 to 50 weight percent A block and 50 to 80 weight percent B block based on the weight of the block copolymer.
  • Suitable block copolymers can be purchased from Kuraray Co., LTD. (Tokyo, Japan) under the trade designations LA POLYMER or KURARITY.
  • LA POLYMER Kuraray Co., LTD. (Tokyo, Japan) under the trade designations LA POLYMER or KURARITY.
  • Some of these block copolymers such as LA2140E, LA2250, LA2330, and LA410L are triblock copolymers with poly(methyl methacrylate) endblocks and a poly(n-butyl acrylate) midblock.
  • the adhesive layer comprises a gel adhesive composition.
  • Gel adhesives comprise a crosslinked polymeric siloxane matrix and a fluid, typically a siloxane fluid.
  • a wide variety of crosslinked polymeric siloxane matrices are suitable for use in the gel adhesive compositions.
  • the matrices can be prepared in a variety of ways.
  • the crosslinked polymeric siloxane matrix can be prepared by thermal curing, condensation curing, radiation curing, or a combination thereof. Particularly suitable is the technique described, for example, in US Patent Publication No.
  • the siloxane gel adhesives can include siloxane tackifying resin.
  • Siloxane tackifying resins are described above.
  • the adhesive layer may be continuous or discontinuous.
  • the thickness of the coated adhesive layer typically in the form of a liquid is in part dependent on the nature of the materials used and the specific properties desired, but those properties and the relationship of thickness to the properties is well understood in the art.
  • Exemplary thicknesses of an adhesive layer may be in the range from about 0.05 to about 100 micrometers.
  • the wound dressing articles may also include an optional absorbent pad.
  • the pad is designed to contact a wound and absorb exudate from the wound.
  • suitable pad materials include cloth and cloth-like materials such as gauze and non-woven fabrics, or foams. Absorbent pad materials are readily known in the art.
  • the articles may include additional optional layers.
  • the primer layer comprises materials that are commonly referred to as “primers” or “adhesion promoters”.
  • Primers and adhesion promoters are materials that are applied as thin coatings on a surface and strongly adhere to the surface and provide a modified surface chemistry to the surface.
  • suitable coating materials include polyamides, poly(meth)acrylates, chlorinated polyolefins, rubbers, chlorinated rubbers, polyurethanes, siloxanes, silanes, polyester, epoxies, polycarbodiimides, phenolics, and combinations thereof.
  • the adhesive layer is covered with a release liner to protect the adhesive layer until used.
  • release liners are suitable for use in the adhesive articles of this disclosure.
  • a wide variety of release liners are suitable.
  • Release liners are commonly used and well understood in the adhesive arts.
  • Exemplary release liners include those prepared from paper (e.g., Kraft paper) or polymeric material (e.g., polyolefins such as polyethylene or polypropylene, ethylene vinyl acetate, polyurethanes, polyesters such as polyethylene terephthalate, and the like, and combinations thereof).
  • At least some release liners are coated with a layer of a release agent such as a silicone -containing material or a fluorocarbon-containing material.
  • Exemplary release liners include, but are not limited to, liners commercially available from CP Film (Martinsville, Va.) under the trade designation "T-30" and "T-10" that have a silicone release coating on polyethylene terephthalate film.
  • the above described packaged articles are typical planar adhesive articles that are folded prior to placement in a package.
  • the regular processing steps to prepare the article are followed, and the prepared article is then folded for packaging.
  • the folding permits a reduction in the amount of packaging material necessary to make the packaged article.
  • packaged medical articles that are not simply folded versions of planar articles.
  • the articles utilize double-sided release liners. Double-sided release liners are well known in the adhesive arts, and are release liners as described above, with release coatings on both major surfaces of the release liner. The release coatings may be the same or they may be different.
  • the first class of articles are folded articles, where the article is folded such that two surfaces of the article are folded such that the two surfaces of the article contact the two release surfaces of the double-sided release liner.
  • the second class of adhesive articles that use a double-sided release liner are articles that have two separate elements disposed on the two release surfaces of the double-sided release liner.
  • the packaged medical article comprises a package enclosing a medical article, and a medical article contained within the package where the medical article comprises an adhesive article comprising a backing layer that has at least three segments.
  • the three segments are a first segment comprising a first adhesive layer, a second segment, adjacent to the first segment, comprising a non-adhesive layer, and a third segment, adjacent to the second segment, comprising a second adhesive layer.
  • the adhesive article has one fold along a fold line along an axis of symmetry of the adhesive article, where the one fold is located in the second segment.
  • the adhesive article also comprises a double-sided release liner with a first release surface and a second release surface, where the first release surface is in contact with adhesive layer of the first segment, and the second release surface is in contact with the adhesive layer of the second segment.
  • the second segment may be a very thin segment and may comprise a non-adhesive line along the axis of symmetry that permits the folding of the article.
  • the segment is larger and may comprise uncoated backing or it may include, for example an absorbent pad as described above.
  • the adhesive layer on the first segment may be the same or different from the adhesive layer on the third segment. Each also may be a continuous or a discontinuous coating of adhesive. Suitable adhesives are described above in detail.
  • Double sided release liners have been described above, with release coatings on both major surfaces of the release liner.
  • the release coatings may be the same or they may be different.
  • the selection of release coatings on the double-sided release liner depends upon a wide variety of factors. For example, if the adhesive coatings on the first segment and the second segment are the same, the release coatings may be the same or they may be different.
  • a similar feature can be achieved through the use of two different adhesive layers and the same release coating on the double-sided release liner.
  • a wide variety of articles of the second class of articles are disclosed. These articles reduce the amount of packaging by including two articles in the same package by using both sides of the double-sided release liner. In these embodiments, the two articles may be the same or they may be different.
  • the packaged medical article comprises a package enclosing a medical article, and a medical article contained within the package where the medical article comprises a double-sided release liner and two adhesive articles adhered to the double-sided release liner.
  • the double-sided release liner has a first release surface with a first release coating and a second release surface with a second release coating, where the first and second release coatings may be the same or different.
  • the first adhesive article is attached to the first release surface of the double-sided release liner, and the second adhesive article is attached to the second release surface of the double-sided release liner.
  • the first and second adhesive articles may be the same or they may be different.
  • Eye patches include an adhesive to hold the patch over the eye.
  • the eye patch article comprises two eye patches, one disposed on each release surface of the double-sided release liner. In this way, a health care worker that is covering the eyes of a patient is able to use a single package to cover both eyes.
  • the packaged article can have different articles disposed on the two release surfaces of the double-sided release liner.
  • an eye patch may be disposed on one of the surfaces of the double-sided release liner and a different adhesive article, such as an attachment article, can be disposed on the second surface of the double-sided release liner, such that the attachment article is available to help to secure the eye patch in place.
  • articles that are not simply folded embodiments of planar articles are articles that specifically designed to be folded. These embodiments include articles where the fold line comprises a gap or division in part of the article, such as the absorbent pad.
  • the gap or division can be imparted in the article by, for example, by cutting or slitting. The gap or division does not pass through the entire article so that the article is not sub-divided into two articles.
  • the methods comprise preparing a packaged medical article, wherein the packaged medical article comprises a packaged medical adhesive article as described above, opening the package, removing the medical article from the package, unfolding the medical article, and applying the medical article to mammalian skin.
  • the packaged medical article comprises a package enclosing the medical article, and a medical article contained within the package wherein the medical article comprises an adhesive article, and wherein the adhesive article comprises at least one fold along an axis of symmetry of the adhesive article.
  • the adhesive article comprises at least three segments where the first segment comprises a first adhesive layer, the second segment, adjacent to the first segment, comprises a non-adhesive layer, and the third segment, adjacent to the second segment, comprising a second adhesive layer, and one fold along an axis of symmetry of the adhesive article, where the one fold is located in the second segment.
  • the article also comprises a double-sided release liner with a first release surface and a second release surface, wherein the first release surface is in contact with the adhesive layer of the first segment, and the second release surface is in contact with the adhesive layer of the second segment.
  • the method further comprises removing the first and second adhesive layers from the double-sided release liner.
  • the method for preparing the packaged medical article comprises preparing an adhesive medical article, folding the adhesive medical article along an axis of symmetry of the adhesive medical article to form a folded medical article, and placing the folded medical article in a package.
  • Figure 1 shows a top view of medical article 100.
  • Article 100 can be folded either along fold line 10 or fold line 20.
  • Figure 2 shows a cross-sectional view of article 100, showing the different segments of the article.
  • Article 100 has backing layer 110. Disposed on backing layer 110 are two adhesive segments 120 and 130, and absorbent segment 140. Release liner 125 is disposed on adhesive segment 120 and release line 135 is disposed on adhesive segment 130. Absorbent segment 140 is bisected by fold line 20.
  • Figure 3 shows a top view of medial article 400, looking down upon the backing layer. Removable liner segments 465 surround transparent absorbent segment 460. Fold line 40 bisects the article.
  • Figure 4 shows a top view of eye patch article 500.
  • Article 500 has non-adhesive region 550 and eye patch 560.
  • Fold line 50 bisects the article.
  • Figure 5 show a cross-sectional view of folded article 600.
  • Folded article 600 has backing layer 610. Disposed on backing layer 610 are two adhesive segments 620 and 330, and absorbent segment 640.
  • Double sided release liner 670 has release surfaces 671 and 672, where release surface 671 is disposed on adhesive segment 620 and release surface 672 is disposed on adhesive segment 630.
  • Figure 6 shows a cross-sectional view of article 700.
  • the article 700 has two adhesive articles (800 and 900) disposed on double sided release liner 770 with release surface 771 and 772.
  • Adhesive article 800 has backing layer 810 and adhesive layer 820.
  • Adhesive layer 820 is disposed on release surface 771.
  • Adhesive article 900 has backing layer 910 and adhesive layer 920.
  • Adhesive layer 920 is disposed on release surface 772.
  • Adhesive articles 800 and 900 may be the same or different. In some embodiments, at least one of 800 and 900 is any eye patch.
  • Figure 7 shows a cross-sectional view of article 1000.
  • the article 1000 demonstrates a gap formed in an adhesive medical article as is described above.
  • article 1000 comprises backing layer 1070 (in this embodiment backing layer 1070 is shown as an optional 2-layer backing layer) with adhesive laver 1020 disposed on it.
  • the article contains a 2-layer absorbent construction, layers 1040 (subdivided into subsegments 1040A and 1040B) and 1041 (subdivided into subsegments 1041A and 105 IB), where layer 1040 is an absorbent pad and layer 1041 is an absorbent foam layer.
  • the absorbent construction is bisected by fold line 20 and by gap 25.
  • the absorbent subsections are disposed on release liner 1025. The gap aids in the folding of the article.
  • a general procedure was used to prepare and test samples of medical adhesive articles.
  • a packaged adhesive article sample with the dimensions shown in Table 1 was removed from the package, folded, and placed into a new package with the dimensions shown in Table 1.
  • the folded sample (Example E) was removed from the package, unfolded and tested by adhering to a stainless-steel plate.
  • An identical unfolded sample (Comparative Example CE) was tested by adhering to a stainless-steel plate.
  • the resulting adhesive attributes of the unfolded and folded samples were compared, and the result is recorded as “Unchanged” if the adhesive sample performed the same as an unfolded sample or “Different” if they behaved differently.
  • the back section of the packages was removed, as the packages were fully self-contained after folding using only the front half of the packaging.
  • the packages were weighed before and after removal of the package backing to show the weight decrease from the material eliminated.
  • 3M OPTICLUDE eye patches are provided with two liners with overlap. Liner overlap was oriented along the long axis of the eye patch. Eye patches were folded along the liner overlap to reduce packaging dimensions. Dimensions before and after folding are shown in Table 4. The sample dimension can be reduced by 50% through folding without compromising the required product design for the designated application.
  • Weight of two patches with one liner (2 * Sample weight of patch without liner) + Sample weight of liner.
  • the weight savings per eye patch have been calculated according to the following formula:
  • Weight savings per eye patch (%>) ((((2 * sample weight initial) (Weight of two patches with one liner)/(2 * sample weight initial))/2) * 100%.
  • Relative Weight Reduction ((Weight Sum of Patch 1 and 2 - Weight of Patch 1 and 2 on double-sided liner) / Weight Sum of Patch 1 and 2) * 100%.
  • the relative packaging dimension reduction from folding each eye patch in half is 50% for all samples, as shown in Table 6.
  • 3M TEGADERM CLEAR ACRYLIC DRESSING is a wound dressing for low to medium exudating wounds.
  • the transparent absorbent pad enables the medical professional to monitor the wound during weartime.
  • Example E16 The commercial sample for Example E16 was folded along the middle axis to not comprise the integrity of the absorbent pad. The same folding procedure can be done for Example E14-E15, and E17-E18. The size reductions of packaged articles in this product family are shown in Table 8.
  • 3M TEGADERM + PAD is a transparent wound dressing with a non-adherent absorbent wound contact layer.
  • the dressings were easily be folded along the middle axis.
  • the absorbent pad and the carrier can be cut along the middle axis folding line to support the fold along folding line.
  • the size reductions of packaged articles in this product family are shown in Table 9.
  • 3M MEDIPORE + PAD is a Soft Cloth Adhesive Wound Dressing.
  • the product construction is basically the same as 3M TEGADERM + PAD except that there is no product carrier and a soft-cloth material is used instead of a transparent polymeric film carrier.
  • the dressings can be folded as described above for 3M TEGADERM + PAD described above.
  • the size reductions of packaged articles in this product family are shown in Table 10.
  • the dressing is a self-adhered, transparent film layer, a honeycomb-shaped absorbent pad, and a release liner.
  • Example E36 a simple cut along the folding axis through the honeycomb-shaped foam material was made using a knife to form a folding line without compromising the product design or the integrity of the absorbent material.
  • Examples E37-E41 a similar cut could be made to form a folding line.
  • the size reductions of packaged articles in this product family are shown in Table 11.
  • BSN LEUKOMED CONTROL is a transparent, absorbent wound dressing.
  • the dressing comprises a transparent film with a transparent carrier for application support as well as several clear absorbent pads.
  • LEUKOMED CONTROL is commercially available in a non-folded, single-packaged sterile package.
  • the separated pads can easily be folded along the short edge of the dressing.
  • the size reductions of packaged articles in this product family are shown in Table 12.
  • 3M TEGADERM SILICONE FOAM BORDER is a highly absorbent wound dressing, which is gentle-to-skin with a long wear time.
  • 3M TEGADERM HP FOAM DRESSING has a multi-layer design, which provides high absorbency with high breathability to reduce the risk of maceration.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Packages (AREA)
  • Adhesives Or Adhesive Processes (AREA)

Abstract

L'invention concerne un article médical emballé qui comprend un emballage renfermant un article médical et un article médical contenu à l'intérieur de l'emballage. L'article médical est un article adhésif, l'article adhésif comprenant au moins un pli le long d'une ligne de pliage le long d'un axe de symétrie de l'article adhésif. Certains des articles adhésifs pliés présentent trois segments, deux segments adhésifs et un tampon absorbant, les deux segments adhésifs étant fixés à une couche de libération à double face.
PCT/IB2021/059684 2020-10-21 2021-10-20 Articles médicaux emballés à emballage réduit WO2022084888A1 (fr)

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US20210238463A1 (en) * 2018-08-23 2021-08-05 3M Innovative Properties Company Tackified and filled silicone adhesive compositions

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