WO2022073479A1 - 用于收集人体与动物呼吸道病毒样本的口罩 - Google Patents

用于收集人体与动物呼吸道病毒样本的口罩 Download PDF

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Publication number
WO2022073479A1
WO2022073479A1 PCT/CN2021/122664 CN2021122664W WO2022073479A1 WO 2022073479 A1 WO2022073479 A1 WO 2022073479A1 CN 2021122664 W CN2021122664 W CN 2021122664W WO 2022073479 A1 WO2022073479 A1 WO 2022073479A1
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layer
mask
sample collection
adjacent
collection layer
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PCT/CN2021/122664
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English (en)
French (fr)
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刘静怡
张武修
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刘静怡
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Publication of WO2022073479A1 publication Critical patent/WO2022073479A1/zh

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    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D13/00—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches
    • A41D13/05—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches protecting only a particular body part
    • A41D13/11—Protective face masks, e.g. for surgical use, or for use in foul atmospheres
    • A—HUMAN NECESSITIES
    • A62—LIFE-SAVING; FIRE-FIGHTING
    • A62B—DEVICES, APPARATUS OR METHODS FOR LIFE-SAVING
    • A62B23/00—Filters for breathing-protection purposes
    • A62B23/02—Filters for breathing-protection purposes for respirators

Definitions

  • the present application relates to a mask for collecting human and animal respiratory virus samples; specifically, the mask is provided with a sample collection layer coated with a nuclease inhibitor.
  • Infectious diseases continue to pose a major threat to human society, usually the seasonal influenza virus that spreads every year, or the new coronavirus (Covid-19), which usually causes considerable damage to human life and property and society.
  • Most infectious diseases with the potential to cause a pandemic can be transmitted to the external environment or other groups through droplets expelled from the respiratory tract. Therefore, in disease prevention, preventing airborne droplets to avoid transmission through the respiratory tract is a top priority.
  • wearing a face shield or mask can effectively prevent ambient airborne droplets from contacting another person through the mouth and respiratory tract, especially medical masks are more effective. Therefore, wearing masks can effectively reduce the spread of human and animal infectious microorganisms, and is also the main equipment for national epidemic prevention.
  • the viability of the collected microorganisms may decrease in a short period of time and may be degraded over time, resulting in insufficient effective virus samples, increasing the chance of false negatives in the test, and making subsequent diagnosis difficult.
  • a sample collection device that can collect potentially infectious microorganisms from the respiratory tract, while reducing the discomfort of the subject being diagnosed.
  • the present application provides a mask for collecting human and animal respiratory virus samples, comprising: a body and at least one strap connecting the body.
  • the body includes: an inner layer; a sample collection layer adjacent to the inner layer; a middle layer adjacent to the sample collection layer; and an outer layer adjacent to the middle layer.
  • the inner layer is a hydrophilic material
  • the middle layer is a melt-blown non-woven fabric with an electric charge
  • the outer layer is a hydrophobic material.
  • the sample collection layer is a meltblown nonwoven fabric coated with a nuclease inhibitor.
  • the sample collection layer is used to collect viruses, bacteria, or fungi.
  • the nuclease inhibitor is an RNase inhibitor or a DNase inhibitor.
  • the melt-blown non-woven fabric is made of a plurality of melt-blown fibers or a plurality of melt-blown fibers through a hot pressing process.
  • the body has a width W, and the length of the sample collection layer along the width W direction is about 4 cm.
  • the body further includes a flexible member adjacent to an edge in the longitudinal direction; wherein the sample collection layer has a first edge and a second edge opposite to it, the first edge is adjacent to the flexible member One side of the member, and the second edge is far away from the other side of the flexible member, from the second edge to the side of the body adjacent to the flexible member 20 has a second width W', the second width W' is about 1/2W.
  • the second width W' is about 8.5 cm.
  • the body has a plurality of folds, and through the folds, the body is folded to form a plurality of inner folds.
  • FIG. 1 is a schematic structural diagram of a mask used for collecting human and animal respiratory virus samples according to the present application.
  • FIG. 2 is a partial cross-sectional view of the mask of FIG. 1 .
  • This application is about a mask for collecting human and animal respiratory virus samples.
  • the microorganisms released from the wearer's mouth and nose can be effectively adsorbed and blocked on the sample collection layer, and the sample collection layer can be further taken out for laboratory testing.
  • such microorganisms include, but are not limited to, viruses, bacteria, or fungi.
  • a mask 100 for collecting human and animal respiratory virus samples including: a body 10, a flexible member 20, and at least one strap 30 for fixing the mask to the face.
  • the body 10 has a length L and a width W, and the flexible member 20 is adjacent to an edge in the length direction.
  • FIG. 2 is a partial cross-sectional view of the mask 100 of FIG. 1 .
  • the mask 100 of the present application is provided with an inner layer 111 , a sample collection layer 112 , a middle layer 113 , and an outer layer 114 from the inside to the outside.
  • the inner layer 111 can be a hydrophilic material, such as a hydrophilic non-woven fabric, which can effectively absorb moisture.
  • the middle layer 113 is a filter layer, which is a melt-blown non-woven fabric with electric charge, and is used to block microorganisms.
  • the outer layer 114 is a waterproof layer, which can be a hydrophobic material, such as a hydrophobic non-woven fabric, for preventing the penetration of water and liquid.
  • the middle layer 113 is made of meltblowing technology.
  • Melt-blown technology is a non-woven sheet product that extrudes molten polymer through a nozzle surrounded by high-speed blowing gas, thereby randomly depositing a non-woven sheet product, which is suitable for filtering and adsorbing air particles.
  • a meltblown nonwoven fabric can be produced by the following method: the nonwoven fabric material is melted at a high temperature, and after the melt is ejected from the spinning nozzle in a fibrous form, the fibrous melt is drawn by a high-temperature and high-speed gas. to obtain a plurality of meltblown fibers on the collecting device.
  • meltblown nonwoven fabric can be obtained by directly collecting a plurality of meltblown fibers.
  • the present application is not limited thereto, and in other embodiments, the collected meltblown fibers can be subjected to a hot pressing process to obtain a meltblown fiber nonwoven film.
  • the sample collection layer 112 is made of melt-blown non-woven fabric.
  • the difference from the middle layer 113 is that the sample collection layer 112 is coated with a nuclease inhibitor.
  • Ribonuclease inhibitors are large molecular weight ( ⁇ 49kDa), acidic (pI ⁇ 4.7), leucine-rich repeat proteins that can form tight complexes with specific nucleases body (complex).
  • the nuclease inhibitor should use a nuclease inhibitor with biocompatibility and low toxicity. More specifically, the nuclease inhibitor can be an RNase (RNase) inhibitor or a DNAse (DNase) inhibitor, which can be replaced according to actual needs.
  • RNase RNase
  • DNase DNAse
  • the sample collection layer 112 has a collection area 1121 located at the center in the length direction of the sample collection layer.
  • the collection area is the main area for collecting microbial particles, and also the area where most of the microorganisms released from the nose and mouth droplets adhere to the collection layer. Accordingly, the collection area 1121 can be configured to be separated or torn from the sample collection layer 112 .
  • the mask 100 of the present application can prolong the period during which microorganisms are attached to the mask, which is helpful for diagnosing whether the wearer has or is infected with related pathogens or diseases. For example, if a patient is suspected of being infected with the coronavirus disease, the patient can be made to wear the mask 100 of the present application, and the collection area 1121 of the sample collection layer 112 can be removed within a certain period of time, and further test in the laboratory for infection with specific microorganisms .
  • the mask 100 of the present application is helpful for diagnosing whether a patient is infected with specific microorganisms, so that the time for collecting samples is not limited to the period during which medical testing personnel collect samples, and it is easier to collect for a longer time, which is beneficial to quarantine and epidemic prevention measures.
  • the strips 30 are preferably two sets of strips, which can be ear-hook or strap-type strips, or other strips that can be used to fix the position of the mask.
  • One end of the strap 30 is fixed to the upper end of the main body 10 , and the other end is fixed to the lower end of the main body 10 .
  • the body 10 has a length L and a width W.
  • the width W is between 15-20 centimeters (cm). In a more preferred embodiment, the width W is about 17.5 cm.
  • the length of the sample collection layer 112 along the width W direction is about 4 cm.
  • the length of the collection area 1121 along the length L direction is about 6 cm.
  • the body 10 has a plurality of folds 101 , and through the folds, the body 10 can be folded to form a plurality of inner pleats.
  • the sample collection layer 112 has a first edge and a second edge opposite to it, wherein the first edge is adjacent to one side of the flexible member 20 , and the second edge is away from the flexible member 20 on the other side. From the second edge to the side of the body 10 adjacent to the flexible member 20, there is a second width W', and the second width W' is about 1/2W. Or in another embodiment, the second width W' is about 8.5 cm.
  • the virus used in this application is coronavirus (Coronavirus OC43), but the mask of this application is not limited to collecting viruses, but can also be applied to other infectious microorganisms.
  • the aseptically treated sample collection layer 112 is obtained, coated with nuclease inhibitor, divided into 5 experimental groups, and then placed in a culture plate. 10 microliters ( ⁇ l) of virus samples (TCID 50 : 10 2 , 10 1 , and 10 0 /ml) with different virus amounts were taken, dropped on the aforementioned sample collection layer 112, and placed at room temperature.
  • the sample collection layer 112 was taken out at 0, 24, 48, and 72 hours, respectively, and immediately immersed in a virus transport medium (VTM) to effectively release and separate out virus particles.
  • VTM virus transport medium
  • the detectable qPCR critical cycles were 31.46, 30.83, and 32.86.
  • the detectable qPCR critical cycles were 37.09, 34.69, and 36.22, respectively.
  • the mask 100 of the present application can retain virus particles on the sample collection layer 112 for up to 48 hours due to the sample collection layer 112, which can overcome the shortcoming that ordinary viruses cannot be stored for a long time at room temperature.
  • this disclosure will be beneficial to diagnosis and quarantine.
  • the filtration efficiency and pressure loss are not significantly reduced, and the standard of a general mask can still be maintained.
  • the mask used for collecting samples of the present application has several advantages, including: on the one hand, it has the purpose of general medical masks, which can isolate foreign microorganisms, and at the same time avoid the release of droplets emitted by the wearer from the upper respiratory tract On the other hand, due to the provision of the sample collection layer, which is coated with nuclease inhibitors, the droplets released by the wearer can stay on it for a longer time. The face of the infected person is removed after a period of time for further detection and diagnosis. After testing, the mask of the present application can adsorb microorganisms (especially viruses) for up to 48 hours, and the virus can still be detected in the sample collection layer after 48 hours. Therefore, in addition to reducing the possibility of infection, the mask used for collecting human and animal respiratory virus samples of the present application can also be helpful for quarantine, making the diagnosis of infectious diseases easier.

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  • General Health & Medical Sciences (AREA)
  • Business, Economics & Management (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
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  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Abstract

一种用于收集人体与动物呼吸道病毒样本的口罩（100），包括：一本体（10），以及连接该本体（10）的至少一条带（30）。该本体（10）包括：一内层（111）；一样本收集层（112），与该内层（111）相邻；一中层（113），与该样本收集层（112）相邻；以及一外层（114），与该中层（113）相邻。该内层（111）为亲水材料，该中层（113）为具有电荷的熔喷不织布，该外层（114）为疏水材料，该样本收集层（112）为涂布核酸酶抑制剂的熔喷不织布。

Description

用于收集人体与动物呼吸道病毒样本的口罩 技术领域
本申请是关于一种用于收集人体与动物呼吸道病毒样本的口罩；具体而言，该口罩设有涂布核酸酶抑制剂的一样本收集层。
背景技术
传染性疾病持续地对人类社会造成重大威胁，通常是每年传播的季节性流感病毒、或者是新型冠状病毒(Covid-19)，通常会造成相当大的人类生命与财产及社会损害。另一方面，大多数可能引发大流行的传染病可通过呼吸道所排出的飞沫传播到外界环境或其他族群。因此，在疾病预防中，防止经由空气传播的飞沫以避免通过呼吸道传播，是首要之务。
据研究报导指出，配戴面罩或口罩可以有效地防止环境空气传播的飞沫通过口腔和呼吸道与另一人接触，尤其医用口罩更有显著功效。因此，配戴口罩可有效减少人类与动物传染性微生物的扩散，亦为全民防疫的主要配备。
此外，收集可能的样本以诊断呼吸道感染时，医生通常必须沿受测对象的鼻腔和咽腔或口咽腔伸入带有棉签的样本收集棒，经常会引起受测者或动物的极大不适感。棉签通常会造成接受样品采集的个人的鼻腔刺激，并使采集过程变得难耐且只能短暂进行采样。目前所用样品收集的方法还严重降低了受测者根据需要而须定时进行采样的意愿。此外，样品采集过程中对受测者的异常刺激也会引起喷嚏和咳嗽，进一步触发恶心感、呕吐、或干咳。这些反射性反应常造成受测者体内部位异常的口沫排放，提高执行收集样本的医护人员吸入和被传染的风险。再者，所收集的微生物生存力可能在短时间内降低并可能因时而降解，造成有效病毒样本不足，增加检验假阴性的机会，造成后续诊断困难。鉴于上述情况，本领域亟需开发可自呼吸道收集可能具感染性微生物的样本收集器材，同时减轻接受诊断的受试者的不适。
发明内容
为解决上述的问题并达成发明的目的，本申请提供一种用于收集人体与动物呼吸道病毒样本的口罩，包括：一本体，以及连接该本体的至少一条带。该本体包括：一内层；一样本收集层，与该内层相邻；一中层，与该样本收集层相邻；以及一外层，与该中层相邻。该内层 为亲水材料，该中层为具有电荷的熔喷不织布，该外层为疏水材料。
于一实施例，该样本收集层为涂布核酸酶抑制剂的熔喷不织布。
于一实施例，该样本收集层用于收集病毒、细菌、或真菌。
于一实施例，该核酸酶抑制剂为RNA酶抑制剂或DNA酶抑制剂。
于一实施例，熔喷不织布为多条熔喷纤维或多条熔喷纤维经热压制程而制成。
于一实施例，该本体一宽度W，该样本收集层沿宽度W方向的长度约为4cm。
于一实施例，该本体另包括一可挠构件，相邻于长度方向的一边缘；其中该样本收集层具有一第一边缘及与其相对的一第二边缘，该第一边缘邻近该可挠构件的一边，而该第二边缘远离该可挠构件的另一边，自第二边缘起至该本体邻近该可挠构件20的一边具有一第二宽度W’，该第二宽度W’约为1/2W。
于一实施例，该第二宽度W’约为8.5cm。
于一实施例，该本体具有复数个折痕，通过该些折痕，该本体折叠构成复数个内褶。
附图说明
图1为本申请的用于收集人体与动物呼吸道病毒样本的口罩的结构示意图。
图2为图1的口罩的部分剖面图。
附图标记说明
100   用于收集人体与动物呼吸道病毒样本的口罩
10    本体
101   折痕
20    可挠构件
30    条带
111   内层
112   样本收集层
1121  收集区
113   中层
114   外层
L     长度
W     宽度
W’    第二宽度。
具体实施方式
本申请的技术特征，包含特定特征，揭示于申请专利范围，针对本申请的技术特征，较佳的理解兹配合说明书、依据本申请原理的实施例、和附图将本申请详细说明如下。
本申请说明书及申请专利范围中所述的所有技术性及科学用语，除非另有所定义，皆为本申请所属技术领域具有通常知识者可知晓的定义。其中单数用语“一”、“一个”、“该”、或其近似用语，除非另有说明，皆可指涉多于一个对象。本说明书使用的“或”、“以及”、“和”，除非另有说明，皆指涉“或/和”。此外，用语“包含”、“包括”皆非有所限制的开放式连接词。前述定义仅说明用语定义的指涉而不应解释为对目标的限制。除非另有说明，本申请所用的材料皆为市售易于取得。
本说明书和权利要求所提及的序数，例如“第一”、“第二”等，仅用于说明所揭示的组件，而非指出或表示组件之间具有任何执行次序，亦非指出或表示于一组件和另一组件之间的次序、或制程的步骤次序。该些序数仅用于使具有某命名的一组件得以和另一具有相同命名的组件能清楚区分。
本申请是关于一种用于收集人体与动物呼吸道病毒样本的口罩。通过设置于口罩中层以及内层中的样本收集层，自配戴者的口鼻所释放的微生物可有效地被吸附以及阻隔于该样本收集层，进一步可取出样本收集层，用于实验室检测。于本申请，该微生物包括但不限于病毒、细菌、或真菌。
图1为本申请的用于收集人体与动物呼吸道病毒样本的口罩100，包括：一本体10、一可挠构件20、以及用于将口罩固定于脸部的至少一条带30。该本体10具有一长度L以及一宽度W，该可挠构件20相邻于长度方向的一边缘。
图2为图1的口罩100的部分剖面图。本申请的口罩100由内而外设有内层111、样本收集层112、中层113、和外层114。内层111可为亲水材料，例如亲水性不织布，可有效吸收水气。中层113为过滤层，为具有电荷的熔喷不织布，用于阻绝微生物。外层114为防水层，可为疏水材料，例如疏水性不织布，用于防止水份、液体渗入。
更特定而言，该中层113由熔喷技术(Meltblowing)所制成。熔喷技术是将熔融的聚合物通过被高速吹塑气体包围的喷嘴挤出，从而随机 沉积的非织造片材产品，可适用于过滤及吸附空气微粒。
于本申请，可通过如下方式来制造熔喷不织布：使不织布材料高温熔融，并使熔融物从纺丝喷嘴呈纤维状喷出后，通过高温高速的气体来牵引所喷出呈纤维状的熔融物，以于收集装置上获得多条熔喷纤维。
于本申请，直接收集多条熔喷纤维即可得到熔喷不织布。然而，本申请不限于此，于其他实施方式，收集到的多条熔喷纤维可再经过热压制程，从而得到熔喷纤维不织布膜。
该样本收集层112是熔喷不织布所构成，与中层113的差异在于，该样本收集层112涂布核酸酶抑制剂。具体而言，核酸酶抑制剂(Ribonuclease inhibitor)为大分子量(～49kDa)且为酸性(pI～4.7)、富白胺酸重复(leucine-rich repeat)的蛋白质，可与特定核酸酶形成紧密复合体(complex)。于本申请，核酸酶抑制剂应使用具有生物兼容性、低毒性的核酸酶抑制剂。更具体而言，该核酸酶抑制剂可为RNA酶(RNase)抑制剂或DNA酶(DNase)抑制剂，可依实际需求替换。
该样本收集层112具有一收集区1121，位于该样本收集层长度方向的中央。该收集区为收集微生物颗粒的主要区域，亦为大多自口鼻飞沫释放的微生物附着于收集层的区域。据此，该收集区1121可组态为：可自该样本收集层112分离或撕取。
通过设置包含核酸酶抑制剂的样本收集层112，本申请的口罩100可延长微生物附着于口罩上的期间，有利于诊断配戴受测者是否带有或感染相关病原体或疾病。例如，若有患者疑似感染冠状病毒疾病，则可令该患者配戴本申请的口罩100，于一定期间内取下该样本收集层112的收集区1121，并于实验室进一步检测是否感染特定微生物。本申请的口罩100有助于诊断患者是否感染特定微生物，让收集样本的时间不限于医疗检测人员收集样本的期间，且较容易更长时间收集，有利于检疫及防疫措施。
此外，该条带30较佳地为二组条带，可为耳挂式或绑带式条带，或其他可用于固定口罩位置的条带。该条带30的一端固定于本体10的上侧端，另一端则固定于本体10的下侧端。
该本体10具有一长度L以及一宽度W。于一较佳实施例，该宽度W介于15-20公分(cm)。于一更佳实施例，该宽度W约17.5cm。
此外，该样本收集层112沿宽度W方向的长度约为4cm。该收集区1121沿长度L方向的长度约6cm。
于另一实施例，该本体10具有复数个折痕101，通过该些折痕， 该本体10可折叠构成复数个内褶。
于另一实施例，该样本收集层112具有一第一边缘及与其相对的一第二边缘，其中该第一边缘邻近该可挠构件20的一边，而该第二边缘远离该可挠构件20的另一边。自第二边缘起至本体10邻近该可挠构件20的一边具有一第二宽度W’，该第二宽度W’约为1/2W。或于另一实施例，该第二宽度W’约为8.5cm。
为测试本申请的口罩100采集样本效率，遂进行以下实验。本申请所使用的病毒为冠状病毒(Coronavirus OC43)，但本申请的口罩不限于收集病毒，亦可应用于其他传染性微生物。
首先取得经无菌处理的样本收集层112，并涂布核酸酶抑制剂，分为5个实验组别后，再放置于培养盘。取不同病毒量的10微升(μl)病毒样本(TCID 50：10 2、10 1、和10 0/ml)，滴于前述样本收集层112，并放置于室温。
于0、24、48、和72小时分别取出样本收集层112，立即浸泡于病毒输送介质(viral transport medium，VTM)中，以有效释放及析出病毒颗粒。
而后，以离心分离病毒后，再萃取病毒RNA，以进行定量PCR(qPCR)。各时间点取得的病毒量揭示于表1。
表1
时间(小时) 病毒量 Rnase抑制剂 Ct
0 100 有 22.82
0 10 有 27.90
0 1 有 31.46
24 100 有 31.46
24 10 有 30.83
24 1 有 32.86
48 100 有 37.09
48 10 有 34.69
48 1 有 36.22
72 100 有 N/a
72 10 有 N/a
72 1 有 N/a
正控制组     20.19
负控制组     N/a
依据表1，于滴入病毒后24小时，若样本收集层112的初始病毒量分别为100、10、1 TCID 50/ml，则可侦测的qPCR临界循环(Ct)分别 为31.46、30.83、及32.86。于滴入病毒后48小时，若样本收集层112的初始病毒量分别为100、10、1 TCID 50/ml，则可侦测的qPCR临界循环(Ct)分别为37.09、34.69、及36.22。于滴入病毒后72小时之后，便无法侦测任何病毒量。
因此，依据表1可得知，本申请的口罩100由于设置样本收集层112，于样本收集层112上可保留病毒颗粒长达48小时，可克服一般病毒无法于室温下长时间保存的缺点，避免病毒于口罩上快速分解而无法侦测其核酸，此揭示将有利于诊断以及检疫。
再者，本申请的口罩100设置样本收集层112后，其滤效及压损并无显著降低，仍可维持一般口罩的标准。
本申请的口罩100的滤效及压损揭示于表2。
表2
  滤效(％) 压损(mmH 2O)
成人口罩1 96.24 4.4
成人口罩2 96.91 4.6
成人口罩3 97.21 3.1
儿童口罩1 94.62 3.8
儿童口罩2 92.08 3.1
儿童口罩3 94.52 2.9
一般合乎国际标准的外科口罩，其滤效应高于90％，而压损应低于8.0，方为合格、可用于医疗用途的口罩。依据表2，无论是制成成人口罩或儿童口罩，本申请的口罩10的滤效均大于90％，以及压损均低于4.5，由此可知本申请的口罩100虽另设置一样本收集层112，但不影响其滤效功能及压损差，仍可有效过滤微生物以及维持其压损值。
综上所述，本申请的用于收集样本的口罩具有多项优势，包括：一方面具有一般医用口罩的用途，可隔绝外来的微生物，同时避免配戴者自上呼吸道所喷发的飞沫释放；另一方面，由于设置样本收集层，其中涂布核酸酶抑制剂，可使配戴者所释放的飞沫停留于其上达更持久时间，除了延长微生物存活停留期间，可配戴于疑似感染者的脸部，待一段时间后取下，进一步用于检测及诊断。经测试，本申请的口罩 可吸附微生物(特别是病毒)长达48小时，于48小时后仍可于样本收集层侦测到病毒。因此，本申请的用于收集人体与动物呼吸道病毒样本的口罩除了有助于降低传染的可能性之外，对于检疫亦可带来帮助，使传染性疾病的诊断更加简便。
于本说明书实施例揭示的内容，本申请所属领域具有通常知识者可明显得知前述实施例仅为例示而非限制；本说明书中的各实施例可单独实施或彼此结合；具本申请所属技术领域通常知识者可通过诸多变换、替换而实施，并不与本申请的技术特征有所差异。依据说明书实施例，本申请可有多种变换仍无碍于实施。本说明书提供的权利要求界定本申请的范围，该范围涵盖前述方法与结构及与其相等的发明。

Claims (9)

  1. 一种用于收集人体与动物呼吸道病毒样本的口罩，包括：
    一本体，包括：
    一内层；
    一样本收集层，与该内层相邻；
    一中层，与该样本收集层相邻；以及
    一外层，与该中层相邻；以及
    至少一条带，连接该本体；
    其中该内层为亲水材料，该中层为具有电荷的熔喷不织布，该外层为疏水材料。
  2. 如权利要求1所述的口罩，其中该样本收集层为涂布核酸酶抑制剂的熔喷不织布。
  3. 如权利要求1所述的口罩，其中该样本收集层用于收集病毒、细菌、或真菌。
  4. 如权利要求2所述的口罩，其中该核酸酶抑制剂为RNA酶抑制剂或DNA酶抑制剂。
  5. 如权利要求1所述的口罩，其中熔喷不织布为多条熔喷纤维或多条熔喷纤维经热压制程而制成。
  6. 如权利要求1所述的口罩，其中该本体具有一宽度W，该样本收集层沿宽度W方向的长度约为4cm。
  7. 如权利要求1所述的口罩，其中该本体另包括一可挠构件，相邻于长度方向的一边缘；
    其中该样本收集层具有一第一边缘及与其相对的一第二边缘，该第一边缘邻近该可挠构件的一边，而该第二边缘远离该可挠构件的另一边，自第二边缘起至该本体邻近该可挠构件的一边具有一第二宽度W’，该第二宽度W’约为1/2W。
  8. 如权利要求1所述的口罩，其中该第二宽度W’约为8.5cm。
  9. 如权利要求1所述的口罩，其中该本体具有复数个折痕，通过该些折痕，该本体折叠构成复数个内褶。
PCT/CN2021/122664 2020-10-06 2021-10-08 用于收集人体与动物呼吸道病毒样本的口罩 WO2022073479A1 (zh)

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