WO2022068377A1 - Binary herbicidal composition and use thereof - Google Patents

Binary herbicidal composition and use thereof Download PDF

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Publication number
WO2022068377A1
WO2022068377A1 PCT/CN2021/110412 CN2021110412W WO2022068377A1 WO 2022068377 A1 WO2022068377 A1 WO 2022068377A1 CN 2021110412 W CN2021110412 W CN 2021110412W WO 2022068377 A1 WO2022068377 A1 WO 2022068377A1
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herbicidal composition
binary
active ingredient
methyl
crops
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PCT/CN2021/110412
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French (fr)
Chinese (zh)
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李平生
金涛
张景远
彭学岗
赵德
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青岛清原化合物有限公司
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Publication of WO2022068377A1 publication Critical patent/WO2022068377A1/en

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A01N43/18—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with sulfur as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/44—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom three- or four-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/66—1,3,5-Triazines, not hydrogenated and not substituted at the ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/88—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with three ring hetero atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/16—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof the nitrogen atom being part of a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/18—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P13/00—Herbicides; Algicides

Definitions

  • the invention belongs to the field of pesticides, and in particular relates to a binary herbicidal composition and application thereof.
  • Chemical weeding is the most economical and effective method for weed control in farmland.
  • the long-term continuous and high-dose use of chemical herbicides of a single species or single mode of action is likely to cause problems such as weed resistance and resistance evolution.
  • the rational compounding or compounding of herbicide compounds has the advantages of expanding the weed spectrum, improving the control effect, delaying the occurrence and development of drug resistance and drug resistance of weeds, etc., and is one of the most effective methods to solve the above problems. Therefore, there is an urgent need to develop herbicidal compositions with high safety, broad herbicidal spectrum, synergistic effects and solving the problem of resistant weeds.
  • the present invention provides a binary herbicidal composition and application thereof.
  • the composition can effectively control weeds in crop fields, such as Maijiagong, Niu chickweed, Baogai grass, sausage, wild carrot, coriander chrysanthemum, and blue cabbage, etc. Synergistic effect and address characteristics such as resistant weeds.
  • a binary herbicidal composition comprising herbicidal effective amounts of active ingredient A and active ingredient B, wherein,
  • Active ingredient A is ciclopirox (CAS number: 1855929-45-1), diflufenazone (CAS number: 1622908-18-2), diflufenazone (CAS number: 1992017-55-6) , Sulfurtrazone (CAS No.: 1911613-97-2),
  • Active ingredient B is selected from one of the following compounds and their acids/salts/esters:
  • Cyptofen (CAS No.: 87818-31-3), trifludimoxazin (CAS No.: 1258836-72-4), Indazine (CAS No.: 950782-86-2), tetflupyrolimet (CAS No.: 2053901- 33-8), dichloroclomazone (CAS number: 81777-95-9), dimesulfazet (CAS number: 1215111-77-5), epyrifenacil (CAS number: 353292-31-6), cyclopyrimorate (CAS number: 353292-31-6) :499231-24-2).
  • the weight ratio of A and B is 1:100 ⁇ 2000:1 or 1:90 ⁇ 1500:1; preferably 1:80 ⁇ 1000:1 or 1:70 ⁇ 800:1; more preferably 1:60 ⁇ 500:1 or 1:50-300:1; more preferably 1:40-200:1 or 1:30-100:1; still more preferably 1:20-80:1, 1:10-50:1 , 1:5 ⁇ 30:1 or 1:1 ⁇ 10:1.
  • the mass percentage content of A and B in the herbicidal composition accounts for 1-95% of the total, preferably 10-80%.
  • the herbicidal composition also includes conventional adjuvants including carriers and/or surfactants.
  • carrier means an organic or inorganic, natural or synthetic substance. They facilitate application of the active ingredient, the carrier being generally inert and must be agriculturally acceptable, especially by the plants being treated.
  • the carrier can be solid, such as clay, natural or synthetic silicates, silica, resins, waxes, solid fertilizers, etc.; or liquid, such as water, alcohols, ketones, petroleum fractions, aromatic or waxy hydrocarbons, chlorine Substitute hydrocarbons, liquefied gas, etc.
  • Surfactants may include emulsifying agents, dispersing agents or wetting agents, which may be ionic or non-ionic. Examples which may be mentioned are the salts of polyacrylic acid, lignosulfonate, phenolsulfonic acid or naphthalenesulfonic acid, ethylene oxide with aliphatic alcohols or with aliphatic acids or with aliphatic amines with substituted phenols (particularly polymers of alkylphenols or arylphenols), sulfosuccinates, taurine derivatives (especially taurine alkyl esters) and phosphate esters of alcohols or polyhydroxyethylated phenols, Alkyl sulfonates, alkylaryl sulfonates, alkyl sulfates, lauryl ether sulfates, fatty alcohol sulfates, and sulfated hexadec-, heptadeca-, and octadecanol and
  • compositions may also contain various other components such as protective colloids, binders, thickeners, thixotropic agents, penetrants, stabilizers, chelating agents, dyes, colorants and polymers.
  • composition of the present invention can be mixed with the following active substances, such as known substances in "World Encyclopedia of Pesticide New Variety Technology", China Agricultural Science and Technology Press, 2010.9 and the documents cited herein.
  • active substances such as known substances in "World Encyclopedia of Pesticide New Variety Technology", China Agricultural Science and Technology Press, 2010.9 and the documents cited herein.
  • the herbicidal active substances mentioned below (Note: the name of the compound, or the common name according to the International Organization for Standardization (ISO), or the chemical name, with a code name when appropriate): Acetochlor, Butachlor, Alachlor, Metolachlor, Metolachlor, Spermatachlor, Pretolachlor, Toxachlor, Clochlor, Naprochlor, R-Levonachlor, Propionil , fenflufen, fenflufen, difenafen, dichlorfen, fenbutafen, brombutafen, dimethafen, high-efficiency dimethafen, ethoxy
  • the herbicidal composition further comprises at least one safener selected from:
  • Dichlorophenylpyrazole carboxylic acid derivatives preferred compounds are, for example, ethyl 1-(2,4-dichlorophenyl)-5-methylpyrazole-3-carboxylate (S1-2), 1-(2,4-Dichlorophenyl)-5-isopropylpyrazole-3-carboxylic acid ethyl ester (S1-3), 1-(2,4-dichlorophenyl)-5-(1 ,1-Dimethyl-ethyl)pyrazole-3-carboxylic acid ethyl ester (S1-4), 1-(2,4-dichlorophenyl)-5-phenylpyrazole-3-carboxylic acid ethyl ester Esters (S1-5), and related compounds described in EP-A-333131 and EP-A-269806.
  • Triazole carboxylic acid (S1) compounds the preferred compound is for example fenchlorazole, namely 1-(2,4-dichlorophenyl)-5-trichloromethyl-(1H)-1 , 2,4-triazole-3-carboxylic acid ethyl ester (S1-6) and related compounds (see EP-A-174562 and EP-A-346620).
  • S2 8-quinolineoxyacetic acid (S2) compounds, preferably 1-methylhex-1-yl (5-chloro-8-quinolineoxy) acetate (S2-1, cloquintocet- mexyl), such as PM (pp. 195-196), (1,3-dimethylbutan-1-yl)(5-chloro-8-quinolinyloxy)acetate (S2-2), 4- Allyloxybutyl (5-chloro-8-quinolinyloxy) acetate (S2-3), 1-allyloxyprop-2-yl (5-chloro-8-quinolinyloxy) yl) acetate (S2-4), (5-chloro-8-quinolinyloxy) ethyl acetate (S2-5), (5-chloro-8-quinolinyloxy) methyl acetate (S2- 6), (5-chloro-8-quinolineoxy) allyl acetate (S2-7), 2-(2-propyleneiminooxy)-1-ethy
  • 5-chloro-8-quinolinyloxy)malonic acid compounds preferred compounds are for example (5-chloro-8-quinolinyloxy)diethyl malonate, (5-chloro-8 -quinolinyloxy)diallyl malonate, (5-chloro-8-quinolinyloxy)-malonate methylethyl ester and related compounds described in EP-A-0582198.
  • phenoxyacetic acid phenoxypropionic acid or aromatic carboxylic acid type active compounds such as 2,4-dichlorophenoxyacetic acid (and ester) (2,4-D), 4-chloro-2- Methylphenoxypropionate (2-methyl-4-chloropropionic acid (mecoprop)), MCPA or 3,6-dichloro-2-methoxybenzoic acid (and ester) (dicamba) .
  • aromatic carboxylic acid type active compounds such as 2,4-dichlorophenoxyacetic acid (and ester) (2,4-D), 4-chloro-2- Methylphenoxypropionate (2-methyl-4-chloropropionic acid (mecoprop)), MCPA or 3,6-dichloro-2-methoxybenzoic acid (and ester) (dicamba) .
  • the safeners are preferably bisfenoxazole acid (CAS: 163520-33-0), cyprosulfamide (CAS: 221667-31-8), pyraclostrobin (CAS: 135590-91-9), quinoquine (CAS: 135590-91-9) : 99607-70-2), one or more of gibberellic acid (CAS: 7-06-5), furilazole (CAS: 121776-33-8), metcamifen (CAS: 129531-12-0).
  • the abbreviated form of the generic name of the active compound includes in each case all customary derivatives, such as esters and salts, as well as isomers, in particular optical isomers, in particular one or more commercially available forms.
  • the common name denotes esters or salts, it also includes in each case all other customary derivatives, such as other esters and salts, free acids and neutral compounds, as well as isomers, especially optical isomers, especially in one or more commercially available forms.
  • the chemical names of compounds given represent at least one compound covered by the generic name, usually the preferred compound.
  • salts also include salts formed by the exchange of cations with hydrogen atoms in the sulfonamide group.
  • 2 methyl 4 chloride derivatives include but are not limited to: 2 methyl 4 chloride sodium salt, potassium salt, dimethylammonium salt, isopropylamine salt, etc., and 2 methyl 4 chloro methyl ester, ethyl ester, isooctyl ester, ethyl sulfide Esters, etc.
  • 2,4-D derivatives include, but are not limited to: 2,4-D salts such as sodium, potassium, dimethylammonium, triethanolammonium, isopropylamine, choline, etc., and 2,4 -D esters such as methyl ester, ethyl ester, butyl ester, isooctyl ester, etc.
  • compositions of the present invention may be diluted or used directly by the user prior to use. Its preparation can be prepared by the usual processing method, that is, after mixing the active substance with a liquid solvent or a solid carrier, and then adding one or more of surfactants such as dispersing agent, stabilizer, wetting agent, adhesive, defoaming agent, etc. kind.
  • surfactants such as dispersing agent, stabilizer, wetting agent, adhesive, defoaming agent, etc. kind.
  • the specific formulations of the herbicidal composition are dispersible oil suspensions, water suspensions, suspoemulsions, wettable powders, emulsifiable concentrates, water dispersible granules (dry suspensions), water emulsions, and microemulsions.
  • compositions of the present invention can be mixed with solid and liquid additives conventionally used in prior art formulations.
  • the amount of active ingredient used varies with external conditions, such as temperature, humidity, properties of herbicides used, and the like. It can vary widely, eg between 0.001 and 1.0 kg/ha, or more active substance, but is preferably between 0.005 and 750 g/ha, especially between 0.005 and 500 g/ha.
  • compositions of the present invention can be applied by spraying to the foliage of the plants to be treated, ie to weeds, especially to surfaces that are infested or susceptible to infestation.
  • the present invention also provides an application of the herbicidal composition in controlling weeds; and a method for controlling unwanted plant growth, comprising applying the herbicidal composition to plants, plant parts, plants The area where seeds or plants grow.
  • the herbicidal composition is used to selectively control weeds in useful crops, more preferably, the useful crops are transgenic crops or crops treated with genome editing technology.
  • the compounds of the present invention can be used to treat all plants and plant parts.
  • Plant varieties and cultivars can be obtained by conventional propagation and breeding methods or by genetic engineering methods.
  • Genetically modified plants are those in which a heterologous gene (transgene) has been stably integrated into the genome of the plant.
  • a transgene defined by its specific location in the plant genome is called a transformation event or transgenic event.
  • Genetically modified plant cultivars that can be treated according to the invention include those resistant to one or more biotic stresses (pests, such as nematodes, insects, mites, fungi, etc.) or abiotic stresses (drought, low temperature, soil salinization etc.), or it contains other desirable features. Plants can be genetically modified to exhibit traits such as herbicide tolerance, insect tolerance, modified oil characteristics or drought tolerance. Useful genetically modified plants comprising a single gene transformation event or a combination of transformation events can be found in CN106659159A. Additional information on the genetic modifications listed therein can be obtained, for example, from publicly available databases maintained by the United States Department of Agriculture.
  • the herbicidal composition of the present invention When the herbicidal composition of the present invention is applied, an unexpected synergistic effect is obtained, and the herbicidal activity is more pronounced than the expected sum of the activities of the individual herbicides, and the activity of the individual herbicides.
  • the synergistic effects are reduced application rates, a wider weed control spectrum, and faster and longer lasting herbicidal action, characteristics that are desirable in weed control practice.
  • these new compositions are clearly superior to existing herbicides, resulting in reduced use and more environmentally friendly.
  • composition of the present invention is environmentally friendly and is easily degraded in the environment.
  • the herbicidal composition of the present invention has low cost and convenient use, and its popularization and application have huge economic and social benefits.
  • the original medicines were all made of acetone as solvent, diluted with 0.1% emulsifier Tween-80 aqueous solution, and diluted with current use.
  • the soil surface should be sprayed evenly before the weeds germinate, and the spraying amount should be 450 kg/ha.
  • the whole seedlings of surviving weeds were cut off along the soil surface with a blade, and the fresh weight of the weeds was weighed with an analytical balance. For dead weeds, the fresh weight is zero.
  • E-E0 values greater than 10% are synergistic effects, less than -10% are antagonistic effects, and between -10% and 10% are additive effects.
  • X is the fresh weight inhibition rate when the amount of active ingredient A is P
  • Y the fresh weight inhibition rate when the amount of active ingredient B is Q.
  • Table 1 The actual control effect and combined effect evaluation of ciclopirox mixed with indazine diflufenacil on Maijiagong
  • Table 8 The actual control effect and combined effect evaluation of bispyrifone mixed with epyrifenacil on bovine chickweed (post-emergence stem and leaf spray treatment)
  • Table 16 The actual control effect and combined effect evaluation of sulfentrazone mixed with epyrifenacil on lichen (post-emergence stem and leaf spray treatment)
  • the present invention unexpectedly found that the composition is used for controlling grasses, sedges, broad-leaved weeds such as Makjiagong, bovine chickweed, sorghum, sausage, wild carrot, Coriander chrysanthemum, blue cabbage, etc., have surprising and unexpected synergistic effects. This synergistic effect is more pronounced at low doses, which can reduce the dosage of drugs and reduce environmental pollution. Reasonable compounding The agricultural cost is reduced, the weeds with resistance to ALS and ACCase inhibitors are efficient, and the invention has a good application prospect.
  • broad-leaved weeds such as Makjiagong, bovine chickweed, sorghum, sausage, wild carrot, Coriander chrysanthemum, blue cabbage, etc.

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  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The present invention belongs to the field of pesticides, and particularly relates to a binary herbicidal composition and the use thereof. The binary herbicidal composition comprises herbicidally effective amounts of active ingredient A and active ingredient B, wherein active ingredient A is cypyrafluone, bipyrazone, fenpyrazone or tripyrasulfone; and active ingredient B is selected from one of the following compounds and acids/salts/esters thereof: cinmethylin, trifludimoxazin, indaziflam, tetflupyrolimet, bixlozone, dimesulfazet, epyrifenacil and cyclopyrimorate. The composition is capable of effectively preventing and controlling various weed problems, and has characteristics such as expanding the herbicide controlling spectrum, reducing the application amount, being able to produce a synergistic effect, and eliminating resistant weeds.

Description

一种二元除草组合物及其应用A kind of binary herbicidal composition and its application 技术领域technical field
本发明属于农药领域，具体涉及一种二元除草组合物及其应用。The invention belongs to the field of pesticides, and in particular relates to a binary herbicidal composition and application thereof.
背景技术Background technique
化学除草是农田杂草防除中最为经济、有效的手段，但长期连续高剂量地使用单一品种或单一作用方式的化学除草剂，容易造成杂草耐药和抗性演化等问题。除草剂化合物的合理复配或混配具有扩大杂草谱、提高防除效果、延缓杂草耐药性和抗药性的发生与发展等优点，是解决上述问题的最为有效的方法之一。因此生产上亟需开发安全性高、杀草谱广、能够产生增效作用并解决抗性杂草问题的除草组合物品种。Chemical weeding is the most economical and effective method for weed control in farmland. However, the long-term continuous and high-dose use of chemical herbicides of a single species or single mode of action is likely to cause problems such as weed resistance and resistance evolution. The rational compounding or compounding of herbicide compounds has the advantages of expanding the weed spectrum, improving the control effect, delaying the occurrence and development of drug resistance and drug resistance of weeds, etc., and is one of the most effective methods to solve the above problems. Therefore, there is an urgent need to develop herbicidal compositions with high safety, broad herbicidal spectrum, synergistic effects and solving the problem of resistant weeds.
发明内容SUMMARY OF THE INVENTION
为解决现有技术中存在的上述问题，本发明提供一种二元除草组合物及其应用。该组合物能有效防除作物田中的麦家公、牛繁缕、宝盖草、醴肠、野胡萝卜、芫荽菊、遏蓝菜等杂草问题，具有扩大杀草谱、减少施用量、能够产生增效作用并解决抗性杂草等特点。In order to solve the above problems existing in the prior art, the present invention provides a binary herbicidal composition and application thereof. The composition can effectively control weeds in crop fields, such as Maijiagong, Niu chickweed, Baogai grass, sausage, wild carrot, coriander chrysanthemum, and blue cabbage, etc. Synergistic effect and address characteristics such as resistant weeds.
一种二元除草组合物，包括除草有效量的活性成分A和活性成分B，其中，A binary herbicidal composition, comprising herbicidal effective amounts of active ingredient A and active ingredient B, wherein,
活性成分A为环吡氟草酮(CAS号:1855929-45-1)、双唑草酮(CAS号:1622908-18-2)、苯唑氟草酮(CAS号:1992017-55-6)、三唑磺草酮(CAS号:1911613-97-2)、Active ingredient A is ciclopirox (CAS number: 1855929-45-1), diflufenazone (CAS number: 1622908-18-2), diflufenazone (CAS number: 1992017-55-6) , Sulfurtrazone (CAS No.: 1911613-97-2),
Figure PCTCN2021110412-appb-000001
Figure PCTCN2021110412-appb-000001
活性成分B选自以下化合物及其酸/盐/酯中的一种：Active ingredient B is selected from one of the following compounds and their acids/salts/esters:
环庚草醚(CAS号:87818-31-3)、trifludimoxazin(CAS号:1258836-72-4)、茚嗪氟草胺(CAS号:950782-86-2)、tetflupyrolimet(CAS号:2053901-33-8)、二氯异噁草松(CAS号:81777-95-9)、dimesulfazet(CAS号:1215111-77-5)、epyrifenacil(CAS号:353292-31-6)、cyclopyrimorate(CAS号:499231-24-2)。Cyptofen (CAS No.: 87818-31-3), trifludimoxazin (CAS No.: 1258836-72-4), Indazine (CAS No.: 950782-86-2), tetflupyrolimet (CAS No.: 2053901- 33-8), dichloroclomazone (CAS number: 81777-95-9), dimesulfazet (CAS number: 1215111-77-5), epyrifenacil (CAS number: 353292-31-6), cyclopyrimorate (CAS number: 353292-31-6) :499231-24-2).
其中，A、B的重量比为1:100～2000:1或1:90～1500:1；优选为1:80～1000:1或1:70～800:1；更优选为1:60～500:1或1:50～300:1；进一步优选为1:40～200:1或1:30～100:1；更进一步优选为1:20～80:1、1:10～50:1、1:5～30:1或1:1～10:1。Among them, the weight ratio of A and B is 1:100～2000:1 or 1:90～1500:1; preferably 1:80～1000:1 or 1:70～800:1; more preferably 1:60～ 500:1 or 1:50-300:1; more preferably 1:40-200:1 or 1:30-100:1; still more preferably 1:20-80:1, 1:10-50:1 , 1:5～30:1 or 1:1～10:1.
所述除草组合物中A、B的质量百分含量占总量的1-95％，优选10-80％。The mass percentage content of A and B in the herbicidal composition accounts for 1-95% of the total, preferably 10-80%.
所述除草组合物中还包含常规助剂，所述常规助剂包括载体和/或表面活性剂。The herbicidal composition also includes conventional adjuvants including carriers and/or surfactants.
本文中的术语“载体”表示一种有机或无机、天然或合成的物质。它们有助于活性成分的施用，该载体一般是惰性的且必须是农业上可接受的，特别是被处理的植物所接受。载体可以是固体的，如陶土、天然或合成的硅酸盐、二氧化硅、树脂、蜡、固体肥料等；或者液体的，如水、醇类、酮类、石油馏分、芳烃或蜡烃、氯代烃、液化气等。The term "carrier" as used herein means an organic or inorganic, natural or synthetic substance. They facilitate application of the active ingredient, the carrier being generally inert and must be agriculturally acceptable, especially by the plants being treated. The carrier can be solid, such as clay, natural or synthetic silicates, silica, resins, waxes, solid fertilizers, etc.; or liquid, such as water, alcohols, ketones, petroleum fractions, aromatic or waxy hydrocarbons, chlorine Substitute hydrocarbons, liquefied gas, etc.
表面活性剂可包括乳化剂、分散剂或润湿剂，它可以是离子型或非离子型的。可提及的实例是聚丙烯酸的盐、木质素磺酸盐、苯酚磺酸或萘磺酸的盐、环氧乙烷与脂肪族醇或与脂族酸或与脂肪族胺与取代苯酚(特别是烷基苯酚或芳基苯酚)的聚合物、磺基琥珀酸盐、牛磺酸衍生物(特别是牛磺酸烷脂)及醇的磷酸酯或多羟乙基化的苯酚的磷酸酯、烷基磺酸盐、烷基芳基磺酸盐、烷基硫酸盐、月桂基醚硫酸盐、脂肪醇硫酸盐，以及硫酸化十六-、十七-和十八烷醇以及硫酸化脂肪醇乙二醇醚，此外还有萘或萘磺酸与苯酚和甲醛的缩合物、聚氧乙烯辛基苯基醚、乙氧基化异辛基酚、辛基酚或壬基酚、烷基苯基聚乙二醇醚、三丁基苯基聚乙二醇醚、三硬脂基苯基聚乙二醇醚、烷基芳基聚醚醇、醇和脂肪醇/氧化乙烯缩合物、乙氧基化蓖麻油、聚氧乙烯烷基醚、乙氧基化聚氧丙烯、月桂醇聚乙二醇醚缩醛、山梨醇酯、木素亚硫酸盐废液，以及蛋白质、变性蛋白、多糖(例如甲基纤维素)、疏水改性淀粉、聚乙烯醇、聚羧酸盐、聚烷氧基化物、聚乙烯胺、聚乙烯吡咯烷酮及其共聚物。至少需要一种表面活性剂存在，以有利于活性成分在水中的分散并有利于使它们能正确地施用于植物。Surfactants may include emulsifying agents, dispersing agents or wetting agents, which may be ionic or non-ionic. Examples which may be mentioned are the salts of polyacrylic acid, lignosulfonate, phenolsulfonic acid or naphthalenesulfonic acid, ethylene oxide with aliphatic alcohols or with aliphatic acids or with aliphatic amines with substituted phenols (particularly polymers of alkylphenols or arylphenols), sulfosuccinates, taurine derivatives (especially taurine alkyl esters) and phosphate esters of alcohols or polyhydroxyethylated phenols, Alkyl sulfonates, alkylaryl sulfonates, alkyl sulfates, lauryl ether sulfates, fatty alcohol sulfates, and sulfated hexadec-, heptadeca-, and octadecanol and sulfated fatty alcohols Glycol ethers, in addition to naphthalene or naphthalenesulfonic acid condensates with phenol and formaldehyde, polyoxyethylene octylphenyl ether, ethoxylated isooctylphenol, octylphenol or nonylphenol, alkylbenzene polyglycol ethers, tributylphenyl polyglycol ethers, tristearylphenyl polyglycol ethers, alkyl aryl polyether alcohols, alcohol and fatty alcohol/ethylene oxide condensates, ethoxy Castor oil, polyoxyethylene alkyl ether, ethoxylated polyoxypropylene, lauryl polyglycol ether acetal, sorbitol ester, lignin sulfite waste liquor, and protein, denatured protein, polysaccharide (such as methylcellulose), hydrophobically modified starch, polyvinyl alcohol, polycarboxylates, polyalkoxylates, polyvinylamine, polyvinylpyrrolidone and their copolymers. At least one surfactant needs to be present in order to facilitate dispersion of the active ingredients in water and to facilitate their proper application to plants.
上述组合物也可含有各种其他的组分，如保护胶体、粘合剂、增稠剂、触变剂、渗透剂、稳定剂、螯合剂、染料、着色剂和聚合物。The above compositions may also contain various other components such as protective colloids, binders, thickeners, thixotropic agents, penetrants, stabilizers, chelating agents, dyes, colorants and polymers.
另外，本发明的组合物可以与以下活性物质混合，例如《世界农药新品种技术大全》，中国农业科学技术出版社，2010.9和这里引用的文献中的已知物质。例如以下提到的除草剂活性物质，(备注:化合物的名称，或者为根据国际标准化组织(ISO)的普通名称，或者为化学名称，适当的时候有代号):乙草胺、丁草胺、甲草胺、异丙草胺、异丙甲草胺、精异丙甲草胺、丙草胺、毒草胺、克草胺、萘丙酰草胺、R-左旋萘丙酰草胺、敌稗、苯噻酰草胺、双苯酰草胺、吡氟酰草胺、杀草胺、氟丁酰草胺、溴丁酰草胺、二甲噻草胺、高效二甲噻草胺、乙氧苯草胺、氟噻草胺、甲氧噻草胺、吡草胺、异恶草胺、高效麦草伏甲酯、高效麦草伏丙酯、二丙烯草胺、烯草胺、丁酰草胺、环丙草胺、氟磺酰草胺、庚酰草胺、异丁草胺、丙炔草胺、特丁草胺、二甲苯草胺、二甲草胺、落草胺、三甲环草胺、氯甲酰草胺、炔苯酰草胺、戊酰苯草胺、卡草胺、新燕灵、三环赛草胺、丁烯草胺、牧草胺、苄草胺、醌萍胺、苯氟磺胺、萘丙胺、乙酰甲草胺、萘草胺、噻草胺、吡氰草胺、苯草多克死、草克乐、氯酞亚胺、丁脒胺、氟吡草胺、莠去津、西玛津、扑草净、氰草净、西草净、莠灭净、扑灭津、异丙净、 氟草净、特丁净、特丁津、三嗪氟草胺、环丙津、甘扑津、草达津、扑灭通、西玛通、叠氮净、敌草净、异戊乙净、环丙青津、灭莠津、另丁津、仲丁通、特丁通、甲氧丙净、氰草净、抑草津、可乐津、莠去通、灭草通、甘草津、三聚氰酸、Indaziflam、氯磺隆、甲磺隆、苄嘧磺隆、氯嘧黄隆、苯磺隆、噻磺隆、吡嘧黄隆、甲基二磺隆、甲基碘磺隆钠盐、甲酰氨基嘧磺隆、醚磺隆、醚苯磺隆、甲嘧磺隆、烟嘧磺隆、胺苯磺隆、酰嘧磺隆、乙氧嘧磺隆、环丙嘧磺隆、砜嘧磺隆、四唑嘧磺隆、啶嘧黄隆、单嘧磺隆、单嘧磺酯、氟唑磺隆、氟啶嘧磺隆、氟吡嘧磺隆、环氧嘧磺隆、唑吡嘧磺隆、氟嘧磺隆、丙苯磺隆、三氟丙磺隆、磺酰磺隆、三氟啶磺隆、氟胺磺隆、三氟甲磺隆、甲磺隆钠盐、氟吡磺隆、甲硫嘧磺隆、嘧苯胺磺隆、Propyrisulfuron(丙嗪嘧磺隆)、嗪吡嘧磺隆、三氟羧草醚、氟磺胺草醚、乳氟禾草灵、乙羧氟草醚、乙氧氟草醚、草枯醚、苯草醚、氯氟草醚乙酯、甲羧除草醚、三氟甲草醚、甲氧除草醚、三氟硝草醚、氟化除草醚、氟呋草醚、除草醚、甲草醚、二甲草醚、氟酯肟草醚、氟草醚酯、Halosafen、绿麦隆、异丙隆、利谷隆、敌草隆、莎扑隆、氟草隆、苯噻隆、甲基苯噻隆、苄草隆、磺噻隆、异恶隆、特丁噻草隆、炔草隆、氯溴隆、甲基杀草隆、酰草隆、甲氧杀草隆、溴谷隆、甲氧隆、绿谷隆、灭草隆、环草隆、非草隆、氟硫隆、草不隆、枯草隆、草完隆、异草完隆、环莠隆、噻氟隆、丁噻隆、枯莠隆、对氟隆、甲胺噻唑隆、隆草特、三甲异脲、恶唑隆、Monisouron、Anisuron、Methiuron、Chloreturon、四氟隆、甜菜宁、甜菜宁-乙酯、甜菜安、磺草灵、特草灵、燕麦灵、苯胺灵、氯苯胺灵、二氯苄草酯、灭草灵、氯炔灵、Carboxazole、Chlorprocarb、Fenasulam、BCPC、CPPC、Carbasulam、丁草特、禾草丹、灭草猛、禾草特、野麦畏、哌草丹、禾草畏、稗草丹、环草敌、燕麦敌、菌达灭、乙硫草特、坪草丹、克草猛、苄草丹、仲草丹、硫烯草丹、草灭散、Isopolinate、Methiobencarb、2,4-D异辛酯丁酯、2甲4氯钠、2,4-D异辛酯异辛酯、2甲4氯异辛酯、2,4-D异辛酯钠盐、2,4-D异辛酯二甲胺盐、2甲4氯乙硫酯、2甲4氯、2,4-D异辛酯丙酸、高2,4-D异辛酯丙酸盐、2,4-D异辛酯丁酸、2甲4氯丙酸、2甲4氯丙酸盐、2甲4氯丁酸、2,4,5-涕、2,4,5-涕丙酸、2,4,5-涕丁酸、2甲4氯胺盐、麦草畏、抑草蓬、伐草克、赛松、三氯苯酸、氨二氯苯酸、甲氧三氯苯酸、禾草灵、吡氟禾草灵、精吡氟禾草灵、氟吡甲禾灵、高效吡氟氯禾灵、喹禾灵、精喹禾灵、恶唑禾草灵、精恶唑禾草灵、喔草酯、氰氟草酯、恶唑酰草胺、炔草酯、噻唑禾草灵、炔禾灵、羟戊禾灵、三氟禾草肟、异恶草醚、百草枯、敌草快、安磺灵、乙丁烯氟灵、异丙乐灵、甲磺乐灵、环丙氟灵、氨基丙氟灵、乙丁氟灵、氯乙氟灵、氨基乙氟灵、地乐灵、氯乙地乐灵、Methalpropalin、丙硝酚、草甘膦、莎稗膦、草铵膦、甲基胺草磷、草硫膦、哌草膦、双丙氨膦、地散磷、抑草磷、蔓草磷、伐垅磷、双甲胺草磷、草特磷、咪唑烟酸、咪唑乙烟酸、咪唑喹啉酸、甲氧咪草烟、甲氧咪草烟铵盐、甲咪唑烟酸、咪草酯、氯氟吡氧乙 酸、氯氟吡氧乙酸异辛酯、二氯吡啶酸、氨氯吡啶酸、三氯吡氧乙酸、氟硫草定、卤草定、三氯吡啶酚、噻草啶、氟啶草酮、氯氨吡啶酸、氟吡草腙、三氯吡氧乙酸丁氧基乙酯、Cliodinate、稀禾啶、烯草酮、噻草酮、禾草灭、环苯草酮、丁苯草酮、肟草酮、吡喃草酮、Buthidazole、嗪草酮、环嗪酮、苯嗪草酮、乙嗪草酮、Ametridione、Amibuzin、溴苯腈、辛酰溴苯腈、辛酰碘苯腈、碘苯腈、敌草腈、二苯乙腈、双唑草腈、羟敌草腈、Iodobonil、唑嘧磺草胺、双氟磺草胺、五氟磺草胺、磺草唑胺、氯酯磺草胺、双氯磺草胺、啶磺草胺、氟草黄、双草醚、嘧啶肟草醚、环酯草醚、嘧草醚、嘧硫草醚、双环磺草酮、硝磺草酮、磺草酮、Tembotrione、Tefuryltrione、Bicyclopyrone、Ketodpiradox、异恶唑草酮、异恶氯草酮、Fenoxasulfone、Methiozolin、异丙吡草酯、吡草醚、吡唑特、野燕枯、苄草唑、吡草酮、吡氯草胺、Pyrasulfotole、苯唑草酮、Pyroxasulfone、唑草胺、氟胺草唑、杀草强、氨唑草酮、唑啶草酮、氟唑草酮、甲磺草胺、Bencarbazone、双苯嘧草酮、氟丙嘧草酯、除草定、异草定、环草啶、特草定、Flupropacil、吲哚酮草酯、氟烯草酸、丙炔氟草胺、炔草胺、酞苄醚、Flumezin、五氯酚(钠)、地乐酚、特乐酚、特乐酯、戊硝酚、二硝酚、氯硝酚、地乐施、地乐特、丙炔恶草酮、恶草酮、环戊恶草酮、氟唑草胺、嗪草酸甲酯、四唑酰草胺、氟哒嗪草酯、杀草敏、溴莠敏、二甲达草伏、哒草醚、草哒酮、草哒松、哒草伏、Pyridafol、二氯喹啉酸、氯甲喹啉酸、苯达松、哒草特、恶嗪草酮、草除灵、异恶草酮、环庚草醚、异丙酯草醚、丙酯草醚、茚草酮、氯酸钠、茅草枯、三氯醋酸、一氯醋酸、六氯丙酮、四氟丙酸、牧草快、溴酚肟、三唑磺、灭杀唑、呋草酮、呋草磺、乙呋草磺、嘧草胺、氯酞酸、氟咯草酮、稗草稀、丙烯醛、苯草灭、灭草环、燕麦酯、噻二唑草胺、棉胺宁、羟草酮、甲氧苯酮、苯嘧磺草胺、氯酰草膦、三氯丙酸、Alorac、Diethamquat、Etnipromid、Iprymidam、Ipfencarbazone、Thiencarbazone-methyl、Pyrimisulfan、Chlorflurazole、Tripropindan、Sulglycapin、甲硫磺乐灵、Cambendichlor、环丙嘧啶酸、硫氰苯胺、解草酮、解草啶、解草安、解草唑、解草喹、解草腈、解草烷、解草胺腈、解草烯、吡唑解草酯、呋喃解草唑、肟草安、双苯噁唑酸、二氯丙烯胺、氟氯吡啶酯、DOW氯氟吡啶酯、UBH-509、D489，LS 82-556、KPP-300、NC-324、NC-330、KH-218、DPX-N8189、SC-0744、DOWCO535、DK-8910、V-53482、PP-600、MBH-001、KIH-9201、ET-751、KIH-6127和KIH-2023。In addition, the composition of the present invention can be mixed with the following active substances, such as known substances in "World Encyclopedia of Pesticide New Variety Technology", China Agricultural Science and Technology Press, 2010.9 and the documents cited herein. For example, the herbicidal active substances mentioned below, (Note: the name of the compound, or the common name according to the International Organization for Standardization (ISO), or the chemical name, with a code name when appropriate): Acetochlor, Butachlor, Alachlor, Metolachlor, Metolachlor, Spermatachlor, Pretolachlor, Toxachlor, Clochlor, Naprochlor, R-Levonachlor, Propionil , fenflufen, fenflufen, difenafen, dichlorfen, fenbutafen, brombutafen, dimethafen, high-efficiency dimethafen, ethoxy Benzochlor, Flufentrachlor, Cycloxachlor, Metazachlor, Clomazachlor, Betadine, Betadine, Propylchloride, Diacloprid, Clethachlor, Butyroxychlor, Cypropachlor, Fenfenac, Heptachlor, Mebutachlor, Proclamichlor, Tebuchlor, Xyloxychlor, Dimethachlor, Nocloxachlor, Trimethachlor, Chlorine carboxychlor, propargachlor, valerate, carboxychlor, Xinyanling, tricyclic chlorfenapyr, chlorfenapyr, chlorfenapyr, pendimethalin, quinafenamide, benfluenamide , naphthromycin, acetochlor, naphtachlor, cyclachlor, cyatrachlor, azathioprine, chlorpyrifos, chlorphthalimide, butamidine, fenoxachlor, atrazine, Simazine, promethazine, cyanapyridine, simazine, atrazine, permethazine, promethazine, fluroxypyr, terbutazone, terbutyramine, triazine haloxychlor, ciprofloxacin, glycine Promethazine, Caudain, Promethazine, Simatone, Azide, Dipyridine, Isopentyl, Cyclopropazine, Methorazine, Dibutin, Zhongbuton, Tebutin, Methoxypropyl net, cyanapyridine, oxazine, clozine, atrazine, imazapyr, licorice, cyanuric acid, Indaziflam, chlorsulfuron, metsulfuron, bensulfuron, chlorsulfuron, besulfuron Thiosulfuron-methyl, pyrazosulfuron-methyl, methyldisulfuron-methyl, mesosulfuron-methyl sodium salt, formisulfuron-methyl, ethersulfuron-methyl, ethersulfuron-methyl, metsulfuron-methyl, nicosulfuron-methyl , ethametsulfuron, rimsulfuron, ethoxysulfuron, cyprosulfuron, rimsulfuron, tetrazosulfuron, flazasulfuron, monosulfuron, monosulfuron, fluoro Triflusulfuron-methyl, Flusulfuron-methyl, Flupyrisulfuron-methyl, Episulfuron-methyl, Azazosulfuron-ethyl, Flusulfuron-ethyl, Triflusulfuron-methyl, Triflusulfuron-methyl, Sulfosulfuron-ethyl Fluosulfuron-methyl, Flumisulfuron-methyl, Triflusulfuron-methyl, Sulfuron-methyl sodium salt, Flutopsulfuron-methyl, Methiosulfuron-methyl, Trifensulfuron-methyl, Propyrisulfuron (promethazulfuron), azithromycin Sulfuron-methyl, acifluorfen, fomesafen, lactofen, acifluorfen, oxyfluorfen, acifluorfen, acifluorfen, chlorofluorfen ethyl ester, carboxyl herbicide Ether, dicoflofen, methoxyfen, fenflufen, fluorinated fenflufen, fenflufen, fenflufen, dicoflofen, dicoflofen, fenflufen, fluorfen Esters, Halosafen, Chlormeron, Isoproturon, Liguron, Diuron, Saprolon, Fluoxuron, Benthiuron, Methylbenthione, Benzoturon, Sulfonthiron, Isoxauron, Tebufendiuron, Clodinafuron, Chlorbromone, Methiuron, Acyloxyuron, Methiuron, Bromuron, Methoxyuron, Methuron, Methuron, Cydiauron, Feluron, Fluthiuron, Turbulon, Subtillon , oxawan, isoxawan, cyclouron, tifluron, buthiuron, cumuron, p-fluron, metthiazolone, longoxate, trimethylisourea, oxazolone, Monisouron, Anisuron, Methiuron , Chloreturon, Tetraflon, Betaine, Betaine-Ethyl, Betadine, Sulcoprop, Tetrapyr, Avenaline, Aniline, Chloraniline, Dichlorobenzyl, Methalazine, Chlorpropargyl , Carboxazole, Chlorprocarb, Fenasulam, BCPC, CPPC, Carbasulam, clovet, chlorpyrifos, chlorfenuron, chlorpyrifos, wild dicamba, piperazine, chlorfen, barnyardgrass dan, ring grass dimethicone, oat dimethicone , Bacteriostat, thiocyanate, Tengcaodan, Kecaomeng, Bencaodan, Zhongcaodan, Thiclothopyr, Clomid, Isopolinate, Methiobencarb, 2,4-D Isooctyl Butyl Ester, 2 methyl 4 sodium chloride, 2,4-D isooctyl isooctyl ester, 2 methyl 4 chloro isooctyl ester, 2,4-D isooctyl ester sodium salt, 2,4-D isooctyl ester dimethylamine salt, 2 methyl 4 chloroethyl thioester, 2 methyl 4 chlorine, 2,4-D isooctyl propionate, homo 2,4-D isooctyl propionate, 2,4-D isooctyl butyrate, 2 methyl 4-chloropropionic acid, 2-methyl-4-chlorobutyric acid, 2-methyl-4-chlorobutyric acid, 2,4,5-alginic acid, 2,4,5-alginic acid, 2,4,5-altibutyric acid, 2-methyl-4-chlorobutyric acid 4 chloramine salts, dicamba, pyrimethamine, valeric, saisone, trichlorobenzoic acid, dichlorobenzoic acid, methoxytrichlorobenzoic acid, chlorfenapyr, fenflufenox, pyridoxine Chlorfenapyr, Diflufenthofop-ethyl, halofop-p-ethyl, quizalofop-p-ethyl, quizalofop-p-ethyl, oxaflufen-ethyl, oxaflufen-ethyl, oxalop-prop, cyhalofop-prop, oxazole Acetamide, clodinafop-propargyl, diflufenapyr, propinoxop-ethyl, oxalofop-ethyl, triflufenacil, clomazone, paraquat, diquat, sulfamethoxazole, diflufenac, Ipromethazine, Mesulfuron, Cyproflurometh, Aminopropalin, Ebutaflume, Chlorethalin, Aminoethfluralin, Dipyralin, Chlorethalazine, Methalpropalin, Propofol , glyphosate, sedge phosphine, glufosinate ammonium, methamidophos, glufosinate, piperazine, bialaphos, disanphos, pyruvate, philphos, vallophos, dimethylamine glufosinate, glufosinate, imazamox, imazethapyr, imazamox, imazethapyr, imazamox ammonium salt, imazamox, imazamox, chlorofluoropyrrole, chlorofluoropyr Isooctyl oxyacetate, clopyralid, amlpyralid, triclopyr, dithiopyr, halopyr, chlorpyridine, fenpyridine, clopyralid, chlorpyridine, Diflufenzopyr, Butoxyethyl Trichloropyridine, Cliodinate, Sethoxydim, Clethodim, Cyclodim, Diflufen, Cyclothim, Butafenone, Oximetrione, Pyran Diflufenone, Buthidazole, Diflufenazone, Cyclazinone, Methoxyfen, Amethoxazone, Ametridione, Amibuzin, Bromoxynil, Octanoyl Bromoxynil, Octanoyl Iodophenil, Iodoxynil, Dibenzonil , Diphenylacetonitrile, Bispyrazone, Oxydioxynil, Iodobonil, sulfentrazone, dioxsulam, penoxsulam, sulfentrazone, sulfentrazone, diclofenac, penoxsulam, fluorfenapyr, bispyrazone, sulfentrazone, cycifenafen, cycifenapyr, sulfentrazone, bicyclosulfuron, mesotrione, sulcotrione, Tembotrione, Tefuryltrione, Bicyclopyrone, Ketodpiradox, isoxaflutole, isoxachlor Tripodone, Fenoxasulfone, Methiozolin, Disopyr, Metazapyr, Pyrazotide, Amphetamine, Carfenapyr, Metazapyr, Dichlorfen, Pyrasulfotole, Toxafen, Pyroxasulfone, Carachlor , Flumepyr, Diflufen, Azafenazone, Penoxazone, Flufenazone, Sulfentrazone, Bencarbazone, Diflufenazone, Flufenapyr , Cyclidine, Tetrachlor, Flupropacil, Indoxamethox-ethyl, Diflufenacil, Profenachlor, Clodintrax, Phthalobenzyl Ether, Flumezin, Pentachlorophenol (Sodium), Dinofen, Terox Phenol, teroxetate, pentrofenol, dinitrophenol, clonofol, dioxazone, diloxet, oxadiazone, oxadiazone, cyclopentazone, fenoxafen, oxadiazon Ester, Tetrafenapyr, Flupyrafen, Methalazine, Bromcarbazine, Dimethapyr, Pyridafen, Pyridone, Pyridasone, Pyridafen, Pyridafol, Quinclorac , quinolinic acid, bentazon, pyridoxate, oxaflutole, chlorfenapyr, clomazone, cycloheptafen, isoprofen, profenafen, indanone, chlorfenapyr Sodium, dichroquat, trichloroacetic acid, monochloroacetic acid, hexachloroacetone, tetrafluoropropionic acid, forage, bromophenol oxime, triazole sulfonic acid, fenazol, furafenone, furasulfonic acid, dioxymethylenesulfonic acid , pyrimethoxamine, chlorophthalic acid, flulotrizone, barnyard grass, acrolein, saflufenacil, imazapyr, avenate, thiadiazole, mesamine, oxydiadone, methoxybenzone , Sulfentrazone, Chlorophosphine, Trichloropropionic Acid, Alorac, Diethamquat, Etnipromid, Iprymidam, Ipfencarbazone, Thiencarbazone-methyl, Pyrimisulfan, Chlorflurazole, Tripropindan, Sulglycapin, Sulfolam, Cambendichlor, Cypro , thiocyananilide, chlorfenazone, chlorfenapyr, fenfen, fenfen, fenox, fennitrile, fenox, fennitrile, fenfen, fenfenac, furan Oxaconazole, Oximefon, Diphenoxazole, Dichloropropenamine, Chlorpyridine, DOW Chlorpyridine, UBH-509, D489, LS 82-556, KPP-300, NC-324, NC- 330, KH-218, DPX-N8189, SC-0744, DOWCO535, DK-8910, V-53482 , PP-600, MBH-001, KIH-9201, ET-751, KIH-6127 and KIH-2023.
所述除草组合物进一步包括至少一种安全剂，其选自：The herbicidal composition further comprises at least one safener selected from:
a)二氯苯基吡唑啉-3-羧酸(S1)类化合物，优选的化合物为例如1-(2,4-二氯苯基)-5-(乙氧基羰基)-5-甲基-2-吡唑啉-3-羧酸乙酯(S1-1，吡唑解草酯(mefenpyr-diethyl)，PM，第594-595页)，以及记载于例如WO91/07874和PM(第594-595页)中的相关化合物。a) Dichlorophenylpyrazoline-3-carboxylic acid (S1) compounds, the preferred compound is for example 1-(2,4-dichlorophenyl)-5-(ethoxycarbonyl)-5-methyl Ethyl-2-pyrazoline-3-carboxylate (S1-1, mefenpyr-diethyl, PM, pp. 594-595), and described, for example, in WO91/07874 and PM (p. 594-595) related compounds in pp. 594-595).
b)二氯苯基吡唑羧酸衍生物，优选的化合物为例如1-(2,4-二氯苯基)-5-甲基吡唑-3-羧酸乙 酯(S1-2)、1-(2,4-二氯苯基)-5-异丙基吡唑-3-羧酸乙酯(S1-3)、1-(2,4-二氯苯基)-5-(1,1-二甲基-乙基)吡唑-3-羧酸乙酯(S1-4)、1-(2,4-二氯苯基)-5-苯基吡唑-3-羧酸乙酯(S1-5)，以及记载于EP-A-333131和EP-A-269806中的相关化合物。b) Dichlorophenylpyrazole carboxylic acid derivatives, preferred compounds are, for example, ethyl 1-(2,4-dichlorophenyl)-5-methylpyrazole-3-carboxylate (S1-2), 1-(2,4-Dichlorophenyl)-5-isopropylpyrazole-3-carboxylic acid ethyl ester (S1-3), 1-(2,4-dichlorophenyl)-5-(1 ,1-Dimethyl-ethyl)pyrazole-3-carboxylic acid ethyl ester (S1-4), 1-(2,4-dichlorophenyl)-5-phenylpyrazole-3-carboxylic acid ethyl ester Esters (S1-5), and related compounds described in EP-A-333131 and EP-A-269806.
c)三唑羧酸(S1)类化合物，优选的化合物为例如解草唑(fenchlorazole)，即1-(2,4-二氯苯基)-5-三氯甲基-(1H)-1,2,4-三唑-3-羧酸乙酯(S1-6)及相关化合物(参见EP-A-174562和EP-A-346620)。c) Triazole carboxylic acid (S1) compounds, the preferred compound is for example fenchlorazole, namely 1-(2,4-dichlorophenyl)-5-trichloromethyl-(1H)-1 , 2,4-triazole-3-carboxylic acid ethyl ester (S1-6) and related compounds (see EP-A-174562 and EP-A-346620).
d)5-苄基-或5-苯基-2-异噁唑啉-3-羧酸类或5,5-二苯基-2-异噁唑啉-3-羧酸类化合物，优选的化合物为例如5-(2,4-二氯苄基)-2-异噁唑啉-3-羧酸乙酯(S1-7)或5-苯基-2-异噁唑啉-3-羧酸乙酯(S1-8)及记载于WO91/08202中的相关化合物，或记载于专利申请(WO-A-95/07897)中的5,5-二苯基-2-异噁唑啉-3-羧酸乙酯(S1-9，双苯噁唑酸(isoxadifen-ethyl))或5,5-二苯基-2-异噁唑啉-3-羧酸正丙酯(S1-10)或5-(4-氟苯基)-5-苯基-2-异噁唑啉-3-羧酸乙酯(S1-11)。d) 5-benzyl- or 5-phenyl-2-isoxazoline-3-carboxylic acid or 5,5-diphenyl-2-isoxazoline-3-carboxylic acid compounds, preferred Compounds such as ethyl 5-(2,4-dichlorobenzyl)-2-isoxazoline-3-carboxylate (S1-7) or 5-phenyl-2-isoxazoline-3-carboxylate Acid ethyl ester (S1-8) and related compounds described in WO91/08202, or 5,5-diphenyl-2-isoxazoline- Ethyl 3-carboxylate (S1-9, isoxadifen-ethyl) or n-propyl 5,5-diphenyl-2-isoxazoline-3-carboxylate (S1-10) or ethyl 5-(4-fluorophenyl)-5-phenyl-2-isoxazoline-3-carboxylate (S1-11).
e)8-喹啉氧基乙酸(S2)类化合物，优选1-甲基己-1-基(5-氯-8-喹啉氧基)乙酸酯(S2-1，解毒喹(cloquintocet-mexyl)，如PM(第195-196页)，(1,3-二甲基丁-1-基)(5-氯-8-喹啉氧基)乙酸酯(S2-2)，4-烯丙基氧基丁基(5-氯-8-喹啉氧基)乙酸酯(S2-3)，1-烯丙基氧基丙-2-基(5-氯-8-喹啉氧基)乙酸酯(S2-4)，(5-氯-8-喹啉氧基)乙酸乙酯(S2-5)，(5-氯-8-喹啉氧基)乙酸甲酯(S2-6)，(5-氯-8-喹啉氧基)乙酸烯丙酯(S2-7)，2-(2-亚丙基亚氨基氧基)-1-乙基(5-氯-8-喹啉氧基)乙酸酯(S2-8)，2-氧代丙-1-基(5-氯-8-喹啉氧基)乙酸酯(S2-9)，以及记载于EP-A-86750、EP-A-94349和EP-A-191736或EP-A-0492366中的相关化合物。e) 8-quinolineoxyacetic acid (S2) compounds, preferably 1-methylhex-1-yl (5-chloro-8-quinolineoxy) acetate (S2-1, cloquintocet- mexyl), such as PM (pp. 195-196), (1,3-dimethylbutan-1-yl)(5-chloro-8-quinolinyloxy)acetate (S2-2), 4- Allyloxybutyl (5-chloro-8-quinolinyloxy) acetate (S2-3), 1-allyloxyprop-2-yl (5-chloro-8-quinolinyloxy) yl) acetate (S2-4), (5-chloro-8-quinolinyloxy) ethyl acetate (S2-5), (5-chloro-8-quinolinyloxy) methyl acetate (S2- 6), (5-chloro-8-quinolineoxy) allyl acetate (S2-7), 2-(2-propyleneiminooxy)-1-ethyl (5-chloro-8- Quinolinyloxy) acetate (S2-8), 2-oxoprop-1-yl (5-chloro-8-quinolinyloxy) acetate (S2-9), and described in EP-A - 86750, EP-A-94349 and related compounds in EP-A-191736 or EP-A-0492366.
f)(5-氯-8-喹啉氧基)丙二酸类化合物，优选的化合物为例如(5-氯-8-喹啉氧基)丙二酸二乙酯、(5-氯-8-喹啉氧基)丙二酸二烯丙酯、(5-氯-8-喹啉氧基)-丙二酸甲基乙酯和记载于EP-A-0582198中的相关化合物。f) (5-chloro-8-quinolinyloxy)malonic acid compounds, preferred compounds are for example (5-chloro-8-quinolinyloxy)diethyl malonate, (5-chloro-8 -quinolinyloxy)diallyl malonate, (5-chloro-8-quinolinyloxy)-malonate methylethyl ester and related compounds described in EP-A-0582198.
g)苯氧基乙酸、苯氧基丙酸或芳族羧酸类活性化合物，例如2,4-二氯苯氧基乙酸(和酯)(2,4-D)、4-氯-2-甲基苯氧基丙酸酯(2-甲-4-氯丙酸(mecoprop))、MCPA或3,6-二氯-2-甲氧基苯甲酸(和酯)(麦草畏(dicamba))。g) phenoxyacetic acid, phenoxypropionic acid or aromatic carboxylic acid type active compounds such as 2,4-dichlorophenoxyacetic acid (and ester) (2,4-D), 4-chloro-2- Methylphenoxypropionate (2-methyl-4-chloropropionic acid (mecoprop)), MCPA or 3,6-dichloro-2-methoxybenzoic acid (and ester) (dicamba) .
h)嘧啶类活性化合物，例如“解草啶(fenclorim)”(PM，第386-387页)(＝4,6-二氯-2-苯基嘧啶)，h) pyrimidine-type active compounds, for example "fenclorim" (PM, pages 386-387) (=4,6-dichloro-2-phenylpyrimidine),
i)二氯乙酰胺类活性化合物，其常用作苗前安全剂(作用于土壤的安全剂)，例如“二氯丙烯胺(dichloromid)”(PM，第270-271页)(＝N,N-二烯丙基-2,2-二氯乙酰胺)，“AR-29148”(＝3-二氯乙酰基-2,2,5-三甲基-1,3-噁唑烷酮，购自Stauffer)，“解草嗪(benoxacor)”(PM，第74-75页)(＝4-二氯乙酰基-3,4-二氢-3-甲基-2H-1,4-苯并噁嗪)，“APPG-1292”(＝N-烯丙基-N[(1,3-二氧戊环-2-基)-甲基]二氯乙酰胺，购自PPG Industries)，“ADK-24”(＝N-烯丙基-N-[(烯丙基氨基 羰基)-甲基]-二氯乙酰胺，购自Sagro-Chem)，“AAD-67”或“AMON4660”(＝3-二氯乙酰基-1-氧杂-3-氮杂-螺[4,5]癸烷，购自Nitrokemia或Monsanto)，“diclonon”或“ABAS145138”或“ALAB145138”(＝(＝3-二氯乙酰基-2,5,5-三甲基-1,3-二氮杂双环[4.3.0]壬烷，购自BASF)，和“furilazol”或“AMON13900”(参见PM，482-483)(＝(RS)-3-二氯乙酰基-5-(2-呋喃基)-2,2-二甲基噁唑烷酮)，i) Active compounds of the dichloroacetamide type, which are commonly used as pre-emergence safeners (soil-acting safeners), such as "dichloromid" (PM, pp. 270-271) (=N,N - diallyl-2,2-dichloroacetamide), "AR-29148" (=3-dichloroacetyl-2,2,5-trimethyl-1,3-oxazolidinone, purchased from From Stauffer), "benoxacor" (PM, pp. 74-75) (=4-dichloroacetyl-3,4-dihydro-3-methyl-2H-1,4-benzo oxazine), "APPG-1292" (=N-allyl-N[(1,3-dioxolan-2-yl)-methyl]dichloroacetamide, available from PPG Industries), "ADK -24" (=N-allyl-N-[(allylaminocarbonyl)-methyl]-dichloroacetamide, available from Sagro-Chem), "AAD-67" or "AMON4660" (=3 - Dichloroacetyl-1-oxa-3-aza-spiro[4,5]decane, available from Nitrokemia or Monsanto), "diclonon" or "ABAS145138" or "ALAB145138" (=(=3-dichloroacetyl-1-oxa-3-aza-spiro[4,5]decane) Chloroacetyl-2,5,5-trimethyl-1,3-diazabicyclo[4.3.0]nonane, available from BASF), and "furilazol" or "AMON13900" (see PM, 482-483 )(=(RS)-3-dichloroacetyl-5-(2-furyl)-2,2-dimethyloxazolidinone),
j)二氯丙酮衍生物类活性化合物，例如，“AMG191”(CAS登记号96420-72-3)(＝2-二氯甲基-2-甲基-1,3-二氧戊环，购自Nitrokemia)，j) Active compounds like dichloroacetone derivatives, for example, "AMG191" (CAS Reg. No. 96420-72-3) (=2-dichloromethyl-2-methyl-1,3-dioxolane, available from from Nitrokemia),
k)氧基亚氨基化合物类活性化合物，其被称为拌种材料，例如，“解草腈(oxabetrinil)”(PM，第689页)(＝(Z)-1,3-二氧戊环-2-基甲氧基亚氨基(苯基)乙腈)，其在拌种中称为安全剂，以防止异丙甲草胺(metolachlor)的损害，“氟草肟(fluxofenim)”(PM，第467-468页)(＝1-(4-氯苯基)-2,2,2-三氟-1-乙酮O-(1,3-二氧戊环-2-基甲基)-肟，其在拌种中称为安全剂，以防止异丙甲草胺(metolachlor)的损害，和“解草胺腈(cyometrinil)”或“A-CGA-43089”(PM，第983页)(＝(Z)-氰基甲氧基亚氨基(苯基)乙腈)，其在拌种中称为安全剂，以防止异丙甲草胺(metolachlor)的损害，k) Active compounds of the class of oxyimino compounds, known as seed dressing materials, eg "oxabetrinil" (PM, p. 689) (=(Z)-1,3-dioxolane -2-ylmethoxyimino(phenyl)acetonitrile), which is called a safener in seed dressing to prevent damage from metolachlor, "fluxofenim" (PM, Pages 467-468) (=1-(4-chlorophenyl)-2,2,2-trifluoro-1-ethanone O-(1,3-dioxolan-2-ylmethyl)- Oximes, which are called safeners in seed dressing to prevent damage from metolachlor, and "cyometrinil" or "A-CGA-43089" (PM, p. 983) (=(Z)-cyanomethoxyimino(phenyl)acetonitrile), which is called a safener in seed dressing to prevent damage from metolachlor,
l)噻唑羧酸酯类活性化合物，其被称为拌种材料，例如“解草安(flurazol)”(PM，第450-451页)(＝2-氯-4-三氟甲基-1,3-噻唑-5-羧酸苄酯)，其在拌种中被称为安全剂，以防止甲草胺(alachlor)和异丙甲草胺的损害，l) Active compounds of the thiazole carboxylate class, known as seed dressing materials, eg "flurazol" (PM, p. 450-451) (=2-chloro-4-trifluoromethyl-1 , benzyl 3-thiazole-5-carboxylate), which is known as a safener in seed dressing to prevent damage from alachlor and metolachlor,
m)萘二羧酸衍生物类活性化合物，其被称为拌种剂，例如“萘二甲酸酐”(PM，第1009-1010页)(＝1,8-萘二甲酸酐)，其在玉米拌种中称为安全剂，以防止硫代氨基甲酸酯除草剂的损害，m) Active compounds of the class of derivatives of naphthalene dicarboxylic acid, which are known as seed dressings, for example "Naphthalenedicarboxylic anhydride" (PM, pages 1009-1010) (=1,8-naphthalenedicarboxylic anhydride), which are Known as a safener in corn seed dressing to prevent damage from thiocarbamate herbicides,
n)色满乙酸(chromaneaceticacid)衍生物类活性化合物，例如，“ACL304415”(CAS登记号31541-57-8)(＝2-84-羧基色满-4-基)乙酸，购自AmericanCyanamid)，n) chromaneacetic acid derivative type active compounds, for example, "ACL304415" (CAS Registry No. 31541-57-8) (=2-84-carboxychroman-4-yl)acetic acid, available from American Cyanamid),
o)除了对有害植物具有除草作用外还对植物具有安全剂作用的活性化合物，例如，“哌草丹(dimepiperate)”或“AMY-93”(PM，第302-303页)(＝S-1-甲基-1-苯基乙基哌啶-1-硫代羧酸酯)，“杀草隆(daimuron)”或“ASK23”(PM，第247页)(＝1-(1-甲基-1-苯基乙基)-3-对甲苯基脲)，“苄草隆(cumyluron)”＝“AJC-940”(＝3-(2-氯苯基甲基)-1-(1-甲基-1-苯基-乙基)脲，参见JP-A-60087254)，“苯甲酮(methoxyphenon)”或“ANK049”(＝3,3'-二甲基-4-甲氧基-二苯甲酮)，“CSB”(＝1-溴-4-(氯甲基磺酰基)苯)(CAS登记号54091-06-4，购自Kumiai)。o) Active compounds which, in addition to their herbicidal action against harmful plants, have a plant safener action, for example, "dimepiperate" or "AMY-93" (PM, pp. 302-303) (=S- 1-Methyl-1-phenylethylpiperidine-1-thiocarboxylate), "daimuron" or "ASK23" (PM, p. 247) (=1-(1-methyl) yl-1-phenylethyl)-3-p-tolylurea), "cumyluron" = "AJC-940" (=3-(2-chlorophenylmethyl)-1-(1 -methyl-1-phenyl-ethyl)urea, see JP-A-60087254), "methoxyphenon" or "ANK049" (=3,3'-dimethyl-4-methoxy - benzophenone), "CSB" (=1-bromo-4-(chloromethylsulfonyl)benzene) (CAS Reg. No. 54091-06-4, available from Kumiai).
所述安全剂优选双苯噁唑酸(CAS：163520-33-0)、cyprosulfamide(CAS：221667-31-8)、吡唑解草酯(CAS：135590-91-9)、解毒喹(CAS：99607-70-2)、赤霉酸(CAS：7-06-5)、furilazole(CAS：121776-33-8)、metcamifen(CAS：129531-12-0)中的一种或多种。The safeners are preferably bisfenoxazole acid (CAS: 163520-33-0), cyprosulfamide (CAS: 221667-31-8), pyraclostrobin (CAS: 135590-91-9), quinoquine (CAS: 135590-91-9) : 99607-70-2), one or more of gibberellic acid (CAS: 7-06-5), furilazole (CAS: 121776-33-8), metcamifen (CAS: 129531-12-0).
在本说明书的上下文中，如果使用活性化合物的通用名称的缩写形式，则在每种情况下 包括所有的常规衍生物，例如酯和盐，以及异构体，特别是光学异构体，特别是一种或多种市售形式。如果通用名称表示酯或盐，则在每种情况下还包括所有其他的常规衍生物，例如其他的酯和盐、游离酸和中性化合物，以及异构体，特别是光学异构体，特别是一种或多种市售形式。给出的化合物的化学名称表示至少一种被通用名称涵盖的化合物，通常是优选的化合物。在磺酰胺如磺酰脲的情况下，盐还包括通过阳离子与磺酰胺基团中的氢原子交换而形成的盐。例如，2甲4氯衍生物包含但不限于：2甲4氯钠盐、钾盐、二甲铵盐、异丙胺盐等，以及2甲4氯甲酯、乙酯、异辛酯、乙硫酯等；2,4-D衍生物包含但不限于：2,4-D盐如钠盐、钾盐、二甲铵盐、三乙醇铵盐、异丙胺盐、胆碱等，以及2,4-D酯如甲酯、乙酯、丁酯、异辛酯等。In the context of this specification, if the abbreviated form of the generic name of the active compound is used, this includes in each case all customary derivatives, such as esters and salts, as well as isomers, in particular optical isomers, in particular one or more commercially available forms. If the common name denotes esters or salts, it also includes in each case all other customary derivatives, such as other esters and salts, free acids and neutral compounds, as well as isomers, especially optical isomers, especially in one or more commercially available forms. The chemical names of compounds given represent at least one compound covered by the generic name, usually the preferred compound. In the case of sulfonamides such as sulfonylureas, salts also include salts formed by the exchange of cations with hydrogen atoms in the sulfonamide group. For example, 2 methyl 4 chloride derivatives include but are not limited to: 2 methyl 4 chloride sodium salt, potassium salt, dimethylammonium salt, isopropylamine salt, etc., and 2 methyl 4 chloro methyl ester, ethyl ester, isooctyl ester, ethyl sulfide Esters, etc.; 2,4-D derivatives include, but are not limited to: 2,4-D salts such as sodium, potassium, dimethylammonium, triethanolammonium, isopropylamine, choline, etc., and 2,4 -D esters such as methyl ester, ethyl ester, butyl ester, isooctyl ester, etc.
本发明的组合物可以由使用者在使用前经稀释或直接使用。其配制可由通常的加工方法制备，即将活性物质与液体溶剂或固体载体混合后，再加入表面活性剂如分散剂、稳定剂、湿润剂、粘合剂、消泡剂等中的一种或几种。The compositions of the present invention may be diluted or used directly by the user prior to use. Its preparation can be prepared by the usual processing method, that is, after mixing the active substance with a liquid solvent or a solid carrier, and then adding one or more of surfactants such as dispersing agent, stabilizer, wetting agent, adhesive, defoaming agent, etc. kind.
所述除草组合物的具体制剂为可分散油悬浮剂、水悬浮剂、悬乳剂、可湿性粉剂、乳油、水分散粒剂(干悬浮剂)、水乳剂、微乳剂。The specific formulations of the herbicidal composition are dispersible oil suspensions, water suspensions, suspoemulsions, wettable powders, emulsifiable concentrates, water dispersible granules (dry suspensions), water emulsions, and microemulsions.
简而言之，本发明的组合物可以和现有技术的配方中常规使用的固体和液体添加剂混合。随着外部条件的变化，有效成分的使用量也不同，外部条件为，例如温度、湿度、使用的除草剂的性质等等。它可以有大的变化幅度，例如在0.001到1.0kg/ha之间，或更多的活性物质，但优选在0.005到750g/ha之间，特别是在0.005到500g/ha之间。Briefly, the compositions of the present invention can be mixed with solid and liquid additives conventionally used in prior art formulations. The amount of active ingredient used varies with external conditions, such as temperature, humidity, properties of herbicides used, and the like. It can vary widely, eg between 0.001 and 1.0 kg/ha, or more active substance, but is preferably between 0.005 and 750 g/ha, especially between 0.005 and 500 g/ha.
另外，本发明的组合物可通过喷雾的方法被施用于待处理植物叶片上，即施用于杂草，特别是杂草侵扰或易侵扰影响的表面上。In addition, the compositions of the present invention can be applied by spraying to the foliage of the plants to be treated, ie to weeds, especially to surfaces that are infested or susceptible to infestation.
进一步，本发明还提供一种所述除草组合物在防治杂草上的应用；以及提供一种防治不想要的植物生长的方法，其包括将所述除草组合物施用于植物、植物部位、植物种子或植物生长的区域。优选地，将所述的除草组合物用于选择性防除有用作物中的杂草，更优选地，所述有用作物为转基因作物或者基因组编辑技术处理过的作物。Further, the present invention also provides an application of the herbicidal composition in controlling weeds; and a method for controlling unwanted plant growth, comprising applying the herbicidal composition to plants, plant parts, plants The area where seeds or plants grow. Preferably, the herbicidal composition is used to selectively control weeds in useful crops, more preferably, the useful crops are transgenic crops or crops treated with genome editing technology.
本发明化合物可用于处理所有植株和植株部分。植株品种和栽培品系可通过常规的繁殖和育种方法或通过基因工程方法获得。经基因修饰的植株(转基因植物)为其中异源性基因(转基因)已被稳定整合进植株的基因组的那些。由它在植物基因组中的特定位置所限定的转基因被称为转化事件或转基因事件。The compounds of the present invention can be used to treat all plants and plant parts. Plant varieties and cultivars can be obtained by conventional propagation and breeding methods or by genetic engineering methods. Genetically modified plants (transgenic plants) are those in which a heterologous gene (transgene) has been stably integrated into the genome of the plant. A transgene defined by its specific location in the plant genome is called a transformation event or transgenic event.
经基因修饰的可根据本发明处理的植株栽培品系包括抵抗一种或多种生物胁迫的那些(害虫，诸如线虫动物、昆虫、螨虫、真菌等)或非生物胁迫(干旱、低温、土壤盐化等)，或其包含其它期望的特征。植株可经基因修饰以表现出性状，例如除草剂耐受性、昆虫耐受性、 修饰的油特征或耐旱性。包含单个基因转化事件或转化事件的组合的可用的经基因修饰的植株可参见CN106659159A。其中所列的基因修饰的另外的信息可得自例如通过美国农业部保持的公共可得的数据库。Genetically modified plant cultivars that can be treated according to the invention include those resistant to one or more biotic stresses (pests, such as nematodes, insects, mites, fungi, etc.) or abiotic stresses (drought, low temperature, soil salinization etc.), or it contains other desirable features. Plants can be genetically modified to exhibit traits such as herbicide tolerance, insect tolerance, modified oil characteristics or drought tolerance. Useful genetically modified plants comprising a single gene transformation event or a combination of transformation events can be found in CN106659159A. Additional information on the genetic modifications listed therein can be obtained, for example, from publicly available databases maintained by the United States Department of Agriculture.
当施用本发明的除草组合物时，获得了预料不到的增效效果，并且除草活性比使用单个除草剂的活性预期总和，以及单个除草剂的活性更为显著。增效效果表现为施用量减少、更宽的杂草控制谱、除草作用更快、更持久，这些特性是杂草控制实践过程中所需要的。就所描述的特性来说，这些新组合物明显地优越于现有的除草剂，达到减量使用，对环境更友好。When the herbicidal composition of the present invention is applied, an unexpected synergistic effect is obtained, and the herbicidal activity is more pronounced than the expected sum of the activities of the individual herbicides, and the activity of the individual herbicides. The synergistic effects are reduced application rates, a wider weed control spectrum, and faster and longer lasting herbicidal action, characteristics that are desirable in weed control practice. In terms of the described properties, these new compositions are clearly superior to existing herbicides, resulting in reduced use and more environmentally friendly.
本发明的增效除草组合物还具有下述优点:The synergistic herbicidal composition of the present invention also has the following advantages:
(1)本发明的组合物为环境友好型，在环境中均易于降解。(1) The composition of the present invention is environmentally friendly and is easily degraded in the environment.
(2)本发明的除草组合物成本低、使用方便，其推广应用有巨大的经济效益和社会效益。(2) The herbicidal composition of the present invention has low cost and convenient use, and its popularization and application have huge economic and social benefits.
具体实施方式Detailed ways
下列实施例并非限制本发明，而只是用来说明本发明是如何实现的。对于某些杂草，这些实施例显示出特别显著的有效性。举例如下：The following examples are not intended to limit the invention, but to illustrate how the invention can be implemented. For certain weeds, these examples show particularly significant effectiveness. An example is as follows:
药效试验：Efficacy test:
1)、供试靶标：1), the test target:
麦家公、牛繁缕、宝盖草、醴肠、野胡萝卜、芫荽菊、遏蓝菜。Maijiagong, beef chickweed, Baogai grass, sausage sausage, wild carrot, coriander chrysanthemum, curly blue cabbage.
2)、试剂：2), reagents:
所需活性成分A中环吡氟草酮、双唑草酮、苯唑氟草酮、三唑磺草酮、
Figure PCTCN2021110412-appb-000002
为本公司生产，其他由试剂公司购买。原药均采用丙酮作溶剂，用含量0.1％乳化剂吐温-80水溶液稀释，现用现稀释。 Among the desired active ingredients A, cyclofenazone, diflufenazone, oxaflutole, triflufenazone,
Figure PCTCN2021110412-appb-000002
Produced by the company, others purchased by the reagent company. The original medicines were all made of acetone as solvent, diluted with 0.1% emulsifier Tween-80 aqueous solution, and diluted with current use.
其中，
Figure PCTCN2021110412-appb-000003
来自专利CN202010281666.4，其制备方法如下： in,
Figure PCTCN2021110412-appb-000003
From patent CN202010281666.4, its preparation method is as follows:
(1)在200毫升的EtOH中加入a(20g,98.3mmol,1.0eq)，然后反应液在0℃条件下 逐滴加入NH 2OHHCl(7.5g,108.1mmol,1.1eq)水溶液(30ml)。滴加完毕后反应液在0℃条件下搅拌3小时，LCMS检测显示原料几乎消耗完毕，有一个主要的新峰生成。将反应液浓缩除去一部分乙醇后倒入100毫升水中，有固体析出，过滤，滤饼用水洗涤后干燥后得到b(20g,93％收率)(白色固体)。 (1) a (20g, 98.3mmol, 1.0eq) was added to 200ml of EtOH, and then the reaction solution was added dropwise NH 2 OHHCl (7.5g, 108.1mmol, 1.1eq) aqueous solution (30ml) at 0°C. After the dropwise addition, the reaction solution was stirred at 0°C for 3 hours. LCMS detection showed that the raw material was almost consumed, and a major new peak was generated. The reaction solution was concentrated to remove a part of ethanol, poured into 100 ml of water, a solid was precipitated, filtered, and the filter cake was washed with water and dried to obtain b (20 g, 93% yield) (white solid).
Figure PCTCN2021110412-appb-000004
Figure PCTCN2021110412-appb-000004
(2)在50毫升的EtOH中依次加入b(5g,22.9mmol,1.0eq)，Fe粉(3.8g,68.6mmol,3eq)，NH 4Cl(2.5g,45.8mmol,2eq)和水(10ml)。然后反应液在80℃条件下反应1小时后LCMS检测到产品峰。反应液用硅藻土过滤后浓缩除去乙醇后加入水(20ml)，乙酸乙酯萃取后经浓缩得到黑色粗品。粗品经柱层析分离纯化之后得到c(2g,46.4％收率)(灰色固体)。 (2) b (5g, 22.9mmol, 1.0eq), Fe powder (3.8g, 68.6mmol, 3eq), NH 4 Cl (2.5g, 45.8mmol, 2eq) and water (10ml) were added to 50ml of EtOH in sequence ). Then the reaction solution was reacted at 80°C for 1 hour, and the product peak was detected by LCMS. The reaction solution was filtered through celite, concentrated to remove ethanol, water (20 ml) was added, extracted with ethyl acetate, and concentrated to obtain a black crude product. The crude product was purified by column chromatography to give c (2 g, 46.4% yield) (grey solid).
Figure PCTCN2021110412-appb-000005
Figure PCTCN2021110412-appb-000005
(3)在20ml醋酸中加入c(1g,5.3mmol,1.0eq)和d(1.1g,5.3mmol,1.0eq)，反应液在110℃条件下反应1小时。LCMS检测到原料基本反应完毕，主峰为产品。浓缩溶剂后粗品经柱层析分离后得到e(1.5g，80.5％产率)(白色固体)。(3) c (1 g, 5.3 mmol, 1.0 eq) and d (1.1 g, 5.3 mmol, 1.0 eq) were added to 20 ml of acetic acid, and the reaction solution was reacted at 110° C. for 1 hour. LCMS detected that the basic reaction of the raw materials was completed, and the main peak was the product. After concentrating the solvent, the crude product was separated by column chromatography to give e (1.5 g, 80.5% yield) (white solid).
Figure PCTCN2021110412-appb-000006
Figure PCTCN2021110412-appb-000006
(4)在8ml DMF中依次加入e(0.4g,1.1mmol,1.5eq)，f(0.18g,1.5mmol,1.3eq)和K 2CO 3(0.2g,1.5mmol,1.3eq)，然后反应液在25℃条件下反应4小时，LCMS检测到产品。向反应液中加入水(10ml)后用乙酸乙酯萃取，有机相用饱和食盐水洗涤(10ml*1)，浓缩有机相后粗品经柱层析分离后得到g(0.3g，60.2％产率)(白色固体)。 (4) In 8ml DMF, e (0.4g, 1.1mmol, 1.5eq), f (0.18g, 1.5mmol, 1.3eq) and K 2 CO 3 (0.2g, 1.5mmol, 1.3eq) were sequentially added, and then reacted The solution was reacted at 25°C for 4 hours, and the product was detected by LCMS. Water (10ml) was added to the reaction solution, extracted with ethyl acetate, the organic phase was washed with saturated brine (10ml*1), the organic phase was concentrated and the crude product was separated by column chromatography to obtain g (0.3g, 60.2% yield). ) (white solid).
Figure PCTCN2021110412-appb-000007
Figure PCTCN2021110412-appb-000007
(5)在6ml DMF中依次加入g(0.3g,0.69mmol,1.0eq)，MeI(0.13g,0.9mmol,1.3eq)和K 2CO 3(0.12g,0.9mmol,1.3eq)，然后反应液在25℃条件下反应2小时。LCMS检测到产品。向反应液中加入水(10ml)后用乙酸乙酯萃取，有机相用饱和食盐水洗涤(10ml*1)，浓缩有机相后粗品经柱层析分离后得到目标产物(0.2g，64.6％产率，R/S＝99/1)(白色固体)。 (5) g (0.3 g, 0.69 mmol, 1.0 eq), MeI (0.13 g, 0.9 mmol, 1.3 eq) and K 2 CO 3 (0.12 g, 0.9 mmol, 1.3 eq) were sequentially added to 6 ml of DMF, and then reacted The solution was reacted at 25°C for 2 hours. Product detected by LCMS. Water (10ml) was added to the reaction solution, extracted with ethyl acetate, the organic phase was washed with saturated brine (10ml*1), the organic phase was concentrated and the crude product was separated by column chromatography to obtain the target product (0.2g, 64.6% yield). ratio, R/S=99/1) (white solid).
Figure PCTCN2021110412-appb-000008
Figure PCTCN2021110412-appb-000008
1H NMR(500MHz,DMSO)δ8.52(s,1H),7.93(d,J＝7.5Hz,1H),7.88(d,J＝9.5Hz,1H),6.61(s,1H),4.89-4.87(m,1H),3.70(s,3H),3.43(s,3H),1.48(d,J＝7.0Hz,3H). 1 H NMR(500MHz,DMSO)δ8.52(s,1H),7.93(d,J=7.5Hz,1H),7.88(d,J=9.5Hz,1H),6.61(s,1H),4.89- 4.87(m, 1H), 3.70(s, 3H), 3.43(s, 3H), 1.48(d, J=7.0Hz, 3H).
3)、试验方法3), test method
3.1)、苗后茎叶喷雾处理:3.1), post-emergence stem and leaf spray treatment:
采用盆栽法培养杂草，待杂草处于3-4叶期时，采用茎叶喷雾均匀喷雾，喷液量按450公斤/公顷计。Weeds were cultivated by potted method, and when the weeds were at the 3-4 leaf stage, the stems and leaves were sprayed evenly, and the spray amount was calculated at 450 kg/ha.
3.2)、土壤封闭处理:3.2), Soil sealing treatment:
对播种覆土的盆钵，于杂草发芽前采用土壤表面均匀喷雾，喷液量按450公斤/公顷计。For the pots that are sown and covered with soil, the soil surface should be sprayed evenly before the weeds germinate, and the spraying amount should be 450 kg/ha.
4)、数据调查与统计分析4), data investigation and statistical analysis
4.1)、调查方法4.1), investigation method
采用绝对数调查法，用刀片沿土壤表面切断存活杂草整株幼苗，用分析天平称量杂草鲜重。对于已经死亡的杂草，按鲜重为零计。Using the absolute number investigation method, the whole seedlings of surviving weeds were cut off along the soil surface with a blade, and the fresh weight of the weeds was weighed with an analytical balance. For dead weeds, the fresh weight is zero.
4.2)、调查时间和次数4.2), investigation time and frequency
处理后移入温室常规培养21天调查，共调查1次。After treatment, they were transferred to the greenhouse for routine cultivation for 21 days for investigation, and the investigation was conducted once.
4.3)、数据统计分析4.3), statistical analysis of data
用Gowing法计算各处理混合组合的理论鲜重抑制率(E0＝X+Y-X*Y/100)，然后与实测抑制率(E)相比较，评价二者混用对杂草的联合作用类型，当E-E0值大于10％为增效作用、 小于-10％为拮抗作用、在-10％～10％之间为加成作用。并根据实际防效和除草剂特点、配方的平衡性等因素确定最佳配比。式中X为活性成分A用量为P时的鲜重抑制率；Y为活性成分B用量为Q时的鲜重抑制率。The theoretical fresh weight inhibition rate (E0=X+Y-X*Y/100) of the mixed combination of each treatment was calculated by the Gowing method, and then compared with the measured inhibition rate (E) to evaluate the combined effect of the two on weeds. E-E0 values greater than 10% are synergistic effects, less than -10% are antagonistic effects, and between -10% and 10% are additive effects. And according to the actual control effect and herbicide characteristics, formula balance and other factors to determine the best ratio. In the formula, X is the fresh weight inhibition rate when the amount of active ingredient A is P; Y is the fresh weight inhibition rate when the amount of active ingredient B is Q.
统计结果见下表1-34，除已标记苗后茎叶喷雾处理外，其他均为土壤封闭处理。Statistical results are shown in Table 1-34 below. Except for the spray treatment of post-emergence stems and leaves that have been marked, all others are soil sealing treatments.
表1环吡氟草酮混配茚嗪氟草胺对麦家公的实际防效与联合作用评价Table 1 The actual control effect and combined effect evaluation of ciclopirox mixed with indazine diflufenacil on Maijiagong
Figure PCTCN2021110412-appb-000009
Figure PCTCN2021110412-appb-000009
表2环吡氟草酮混配tetflupyrolimet对麦家公的实际防效与联合作用评价Table 2 The actual control effect and combined effect evaluation of ciclopirox mixed with tetflupyrolimet on Maijiagong
Figure PCTCN2021110412-appb-000010
Figure PCTCN2021110412-appb-000010
表3环吡氟草酮混配dimesulfazet对麦家公的实际防效与联合作用评价Table 3 The actual control effect and combined effect evaluation of ciclopirox mixed with dimesulfazet on Maijiagong
Figure PCTCN2021110412-appb-000011
Figure PCTCN2021110412-appb-000011
表4环吡氟草酮混配epyrifenacil对麦家公的实际防效与联合作用评价(苗后茎叶喷雾处理)Table 4 The actual control effect and combined effect evaluation of ciclopirox mixed with epyrifenacil on Maijiagong (post-emergence stem and leaf spray treatment)
Figure PCTCN2021110412-appb-000012
Figure PCTCN2021110412-appb-000012
表5双唑草酮混配茚嗪氟草胺对牛繁缕的实际防效与联合作用评价Table 5. The actual control effect and combined effect evaluation of fenoxazone mixed with indazine and diflufenacil on bovine chickweed
Figure PCTCN2021110412-appb-000013
Figure PCTCN2021110412-appb-000013
表6双唑草酮混配tetflupyrolimet对牛繁缕的实际防效与联合作用评价Table 6 The actual control effect and combined effect evaluation of bispyrazone mixed with tetflupyrolimet on bovine chickweed
Figure PCTCN2021110412-appb-000014
Figure PCTCN2021110412-appb-000014
Figure PCTCN2021110412-appb-000015
Figure PCTCN2021110412-appb-000015
表7双唑草酮混配dimesulfazet对牛繁缕的实际防效与联合作用评价Table 7 Evaluation of the actual control effect and combined effect of dicarbazone mixed with dimesulfazet on bovine chickweed
Figure PCTCN2021110412-appb-000016
Figure PCTCN2021110412-appb-000016
表8双唑草酮混配epyrifenacil对牛繁缕的实际防效与联合作用评价(苗后茎叶喷雾处理)Table 8 The actual control effect and combined effect evaluation of bispyrifone mixed with epyrifenacil on bovine chickweed (post-emergence stem and leaf spray treatment)
Figure PCTCN2021110412-appb-000017
Figure PCTCN2021110412-appb-000017
表9苯唑氟草酮混配茚嗪氟草胺对宝盖草的实际防效与联合作用评价Table 9 Evaluation of the actual control effect and combined effect of fenoxafen mixed with indazine and fenoxafen on Baogai grass
Figure PCTCN2021110412-appb-000018
Figure PCTCN2021110412-appb-000018
表10苯唑氟草酮混配tetflupyrolimet对宝盖草的实际防效与联合作用评价Table 10 Evaluation of the actual control effect and combined effect of fenoxafen mixed with tetflupyrolimet on Baogai grass
Figure PCTCN2021110412-appb-000019
Figure PCTCN2021110412-appb-000019
表11苯唑氟草酮混配dimesulfazet对宝盖草的实际防效与联合作用评价Table 11 Evaluation of the actual control effect and combined effect of fenoxafen mixed with dimesulfazet on Baocai
Figure PCTCN2021110412-appb-000020
Figure PCTCN2021110412-appb-000020
表12苯唑氟草酮混配epyrifenacil对宝盖草的实际防效与联合作用评价(苗后茎叶喷雾处理)Table 12 Evaluation of the actual control effect and combined effect of fenoxafen mixed with epyrifenacil on Baogai (post-emergence stem and leaf spray treatment)
Figure PCTCN2021110412-appb-000021
Figure PCTCN2021110412-appb-000021
Figure PCTCN2021110412-appb-000022
Figure PCTCN2021110412-appb-000022
表13三唑磺草酮混配茚嗪氟草胺对醴肠的实际防效与联合作用评价Table 13 The actual control effect and combined effect evaluation of sulfentrazone mixed with indazine fluorachlor on lichen
Figure PCTCN2021110412-appb-000023
Figure PCTCN2021110412-appb-000023
表14三唑磺草酮混配tetflupyrolimet对醴肠的实际防效与联合作用评价Table 14 The actual control effect and combined effect evaluation of sulfentrazone mixed with tetflupyrolimet on lichen
Figure PCTCN2021110412-appb-000024
Figure PCTCN2021110412-appb-000024
表15三唑磺草酮混配dimesulfazet对醴肠的实际防效与联合作用评价Table 15 The actual control effect and combined effect evaluation of sulfentrazone mixed with dimesulfazet on lichen
Figure PCTCN2021110412-appb-000025
Figure PCTCN2021110412-appb-000025
表16三唑磺草酮混配epyrifenacil对醴肠的实际防效与联合作用评价(苗后茎叶喷雾处理)Table 16 The actual control effect and combined effect evaluation of sulfentrazone mixed with epyrifenacil on lichen (post-emergence stem and leaf spray treatment)
Figure PCTCN2021110412-appb-000026
Figure PCTCN2021110412-appb-000026
表17
Figure PCTCN2021110412-appb-000027
混配trifludimoxazin对野胡萝卜的实际防效与联合作用评价(苗后茎叶喷雾处理) Table 17
Figure PCTCN2021110412-appb-000027
Evaluation of the actual control effect and combined effect of mixed trifludimoxazin on wild carrot (post-emergence stem and leaf spray treatment)
Figure PCTCN2021110412-appb-000028
Figure PCTCN2021110412-appb-000028
表18
Figure PCTCN2021110412-appb-000029
混配茚嗪氟草胺对野胡萝卜的实际防效与联合作用评价 Table 18
Figure PCTCN2021110412-appb-000029
Evaluation of the actual control effect and combined effect of mixed indazine diflufenacil on wild carrot
Figure PCTCN2021110412-appb-000030
Figure PCTCN2021110412-appb-000030
Figure PCTCN2021110412-appb-000031
Figure PCTCN2021110412-appb-000031
表19
Figure PCTCN2021110412-appb-000032
混配tetflupyrolimet对野胡萝卜的实际防效与联合作用评价 Table 19
Figure PCTCN2021110412-appb-000032
Evaluation of actual control effect and combined effect of mixed tetflupyrolimet on wild carrot
Figure PCTCN2021110412-appb-000033
Figure PCTCN2021110412-appb-000033
表20
Figure PCTCN2021110412-appb-000034
混配dimesulfazet对野胡萝卜的实际防效与联合作用评价 Table 20
Figure PCTCN2021110412-appb-000034
Evaluation of actual control effect and combined effect of mixed dimesulfazet on wild carrot
Figure PCTCN2021110412-appb-000035
Figure PCTCN2021110412-appb-000035
表21
Figure PCTCN2021110412-appb-000036
混配epyrifenacil对野胡萝卜的实际防效与联合作用评价(苗后茎叶喷雾处理) Table 21
Figure PCTCN2021110412-appb-000036
Evaluation of the actual control effect and combined effect of mixed epyrifenacil on wild carrot (post-emergence stem and leaf spray treatment)
Figure PCTCN2021110412-appb-000037
Figure PCTCN2021110412-appb-000037
表22
Figure PCTCN2021110412-appb-000038
混配cyclopyrimorate对野胡萝卜的实际防效与联合作用评价 Table 22
Figure PCTCN2021110412-appb-000038
Evaluation of actual control effect and combined effect of mixed cyclopyrimorate on wild carrot
Figure PCTCN2021110412-appb-000039
Figure PCTCN2021110412-appb-000039
表23
Figure PCTCN2021110412-appb-000040
混配环庚草醚对芫荽菊的实际防效与联合作用评价 Table 23
Figure PCTCN2021110412-appb-000040
Evaluation of the actual control effect and combined effect of mixed cyptofen on Coriander chrysanthemum
Figure PCTCN2021110412-appb-000041
Figure PCTCN2021110412-appb-000041
Figure PCTCN2021110412-appb-000042
Figure PCTCN2021110412-appb-000042
表24
Figure PCTCN2021110412-appb-000043
混配trifludimoxazin对芫荽菊的实际防效与联合作用评价(苗后茎叶喷雾处理) Table 24
Figure PCTCN2021110412-appb-000043
Evaluation of the actual control effect and combined effect of mixed trifludimoxazin on Coriander chrysanthemum (post-emergence stem and leaf spray treatment)
Figure PCTCN2021110412-appb-000044
Figure PCTCN2021110412-appb-000044
表25
Figure PCTCN2021110412-appb-000045
混配茚嗪氟草胺对芫荽菊的实际防效与联合作用评价 Table 25
Figure PCTCN2021110412-appb-000045
Evaluation of the actual control effect and combined effect of mixed indazine difluchlor on Coriander chrysanthemum
Figure PCTCN2021110412-appb-000046
Figure PCTCN2021110412-appb-000046
表26
Figure PCTCN2021110412-appb-000047
混配tetflupyrolimet对芫荽菊的实际防效与联合作用评价 Table 26
Figure PCTCN2021110412-appb-000047
Evaluation of actual control effect and combined effect of mixed tetflupyrolimet on Coriander chrysanthemum
Figure PCTCN2021110412-appb-000048
Figure PCTCN2021110412-appb-000048
表27
Figure PCTCN2021110412-appb-000049
混配二氯异噁草松对芫荽菊的实际防效与联合作用评价 Table 27
Figure PCTCN2021110412-appb-000049
Actual control effect and combined effect evaluation of mixed dichlorocloxazone against Coriander chrysanthemum
Figure PCTCN2021110412-appb-000050
Figure PCTCN2021110412-appb-000050
表28
Figure PCTCN2021110412-appb-000051
混配dimesulfazet对芫荽菊的实际防效与联合作用评价 Table 28
Figure PCTCN2021110412-appb-000051
Evaluation of the actual control effect and combined effect of mixed dimesulfazet on Coriander chrysanthemum
Figure PCTCN2021110412-appb-000052
Figure PCTCN2021110412-appb-000052
表29
Figure PCTCN2021110412-appb-000053
混配epyrifenacil对芫荽菊的实际防效与联合作用评价(苗后茎叶喷雾处理) Table 29
Figure PCTCN2021110412-appb-000053
Evaluation of the actual control effect and combined effect of mixed epyrifenacil on Coriander chrysanthemum (post-emergence stem and leaf spray treatment)
Figure PCTCN2021110412-appb-000054
Figure PCTCN2021110412-appb-000054
表30
Figure PCTCN2021110412-appb-000055
混配cyclopyrimorate对芫荽菊的实际防效与联合作用评价 Table 30
Figure PCTCN2021110412-appb-000055
Evaluation of actual control effect and combined effect of mixed cyclopyrimorate on Coriander chrysanthemum
Figure PCTCN2021110412-appb-000056
Figure PCTCN2021110412-appb-000056
表31
Figure PCTCN2021110412-appb-000057
混配tetflupyrolimet对遏蓝菜的实际防效与联合作用评价 Table 31
Figure PCTCN2021110412-appb-000057
Evaluation of the actual control effect and combined effect of mixed tetflupyrolimet on C. chinensis
Figure PCTCN2021110412-appb-000058
Figure PCTCN2021110412-appb-000058
表32
Figure PCTCN2021110412-appb-000059
混配dimesulfazet对遏蓝菜的实际防效与联合作用评价 Table 32
Figure PCTCN2021110412-appb-000059
Evaluation of the actual control effect and combined effect of mixed dimesulfazet on Radix chinensis
Figure PCTCN2021110412-appb-000060
Figure PCTCN2021110412-appb-000060
表33
Figure PCTCN2021110412-appb-000061
混配epyrifenacil对遏蓝菜的实际防效与联合作用评价(苗后茎叶喷雾处理) Table 33
Figure PCTCN2021110412-appb-000061
Evaluation of the actual control effect and combined effect of mixed epyrifenacil on blueberry (post-emergence stem and leaf spray treatment)
Figure PCTCN2021110412-appb-000062
Figure PCTCN2021110412-appb-000062
表34
Figure PCTCN2021110412-appb-000063
混配cyclopyrimorate对遏蓝菜的实际防效与联合作用评价 Table 34
Figure PCTCN2021110412-appb-000063
Evaluation of the actual control effect and combined effect of mixed cyclopyrimorate on C. chinensis
Figure PCTCN2021110412-appb-000064
Figure PCTCN2021110412-appb-000064
经过大量试验和探索，本发明意外地发现，所述组合物用于防除禾本科、莎草科、阔叶类杂草例如麦家公、牛繁缕、宝盖草、醴肠、野胡萝卜、芫荽菊、遏蓝菜等，具有令人惊讶的、意想不到的增效作用，这种增效作用在低剂量下表现更为显著，可降低用药量，降低对环境的污染，且合理复配降低了农用成本，对ALS、ACCase抑制剂抗性杂草高效，具有很好的应用前景。同时经过测试在小麦田、玉米田、水稻田、花生、甘蔗、高粱、谷子、马铃薯、油菜、大豆、棉花、蔬菜、早熟禾、高羊茅、结缕草等植物显示良好的选择性和优异的增效作用，可以开发成具有广泛市场价值的除草剂混剂。After a lot of experiments and explorations, the present invention unexpectedly found that the composition is used for controlling grasses, sedges, broad-leaved weeds such as Makjiagong, bovine chickweed, sorghum, sausage, wild carrot, Coriander chrysanthemum, blue cabbage, etc., have surprising and unexpected synergistic effects. This synergistic effect is more pronounced at low doses, which can reduce the dosage of drugs and reduce environmental pollution. Reasonable compounding The agricultural cost is reduced, the weeds with resistance to ALS and ACCase inhibitors are efficient, and the invention has a good application prospect. At the same time, it has been tested in wheat fields, corn fields, rice fields, peanuts, sugarcane, sorghum, millet, potatoes, rapeseed, soybeans, cotton, vegetables, bluegrass, tall fescue, Zoysia and other plants to show good selectivity and excellent The synergistic effect can be developed into herbicide mixtures with wide market value.

Claims (8)

  1. 一种二元除草组合物，其特征在于，包括除草有效量的活性成分A和活性成分B，其中，A binary herbicidal composition is characterized in that it comprises active ingredient A and active ingredient B in herbicidal effective amounts, wherein,
    活性成分A为环吡氟草酮、双唑草酮、苯唑氟草酮、三唑磺草酮、
    Figure PCTCN2021110412-appb-100001
    Active ingredient A is cyclopyrazone, diflufenazone, fenoxaflutole, triflufenazone,
    Figure PCTCN2021110412-appb-100001
    活性成分B选自以下化合物及其酸/盐/酯中的一种：环庚草醚、trifludimoxazin、茚嗪氟草胺、tetflupyrolimet、二氯异噁草松、dimesulfazet、epyrifenacil、cyclopyrimorate。Active ingredient B is selected from one of the following compounds and their acids/salts/esters: cycloheptachlor, trifludimoxazin, indoxafen, tetflupyrolimet, dichlorocloxazone, dimesulfazet, epyrifenacil, cyclopyrimorate.
  2. 根据权利要求1所述的一种二元除草组合物，其特征在于，所述除草组合物中A、B的重量比为1:100～2000:1或1:90～1500:1；优选为1:80～1000:1或1:70～800:1；更优选为1:60～500:1或1:50～300:1；进一步优选为1:40～200:1或1:30～100:1；更进一步优选为1:20～80:1、1:10～50:1、1:5～30:1或1:1～10:1。A binary herbicidal composition according to claim 1, wherein the weight ratio of A and B in the herbicidal composition is 1:100-2000:1 or 1:90-1500:1; preferably 1:80～1000:1 or 1:70～800:1; more preferably 1:60～500:1 or 1:50～300:1; further preferably 1:40～200:1 or 1:30～ 100:1; more preferably 1:20 to 80:1, 1:10 to 50:1, 1:5 to 30:1, or 1:1 to 10:1.
  3. 根据权利要求1或2所述的一种二元除草组合物，其特征在于，所述除草组合物中A、B的质量百分含量占总量的1-95％，优选10-80％。The binary herbicidal composition according to claim 1 or 2, wherein the mass percentage of A and B in the herbicidal composition accounts for 1-95% of the total, preferably 10-80%.
  4. 根据权利要求1或2所述的一种二元除草组合物，其特征在于，所述除草组合物中还包括常规助剂，优选地，所述常规助剂包括载体和/或表面活性剂。A binary herbicidal composition according to claim 1 or 2, characterized in that, the herbicidal composition further comprises a conventional adjuvant, preferably, the conventional adjuvant comprises a carrier and/or a surfactant.
  5. 根据权利要求1或2所述的一种二元除草组合物，其特征在于，所述除草组合物进一步包括至少一种安全剂，优选地，所述安全剂选自双苯噁唑酸、cyprosulfamide、吡唑解草酯、解毒喹、赤霉酸、furilazole、metcamifen中的一种或多种。A binary herbicidal composition according to claim 1 or 2, characterized in that, the herbicidal composition further comprises at least one safener, preferably, the safener is selected from the group consisting of bisoxazole, cyprosulfamide , one or more of pyraclostrobin, quincetaxel, gibberellic acid, furilazole, metcamifen.
  6. 根据权利要求1或2所述的一种二元除草组合物，其特征在于，所述除草组合物的具体制剂为可分散油悬浮剂、水悬浮剂、悬乳剂、可湿性粉剂、乳油、水分散粒剂、水乳剂或微乳剂。A kind of binary herbicidal composition according to claim 1 or 2, is characterized in that, the concrete preparation of described herbicidal composition is dispersible oil suspending agent, water suspending agent, suspoemulsion, wettable powder, emulsifiable concentrate, water Dispersible granules, aqueous emulsions or microemulsions.
  7. 如权利要求1-6任意一项所述的一种二元除草组合物在防治杂草上的应用，优选地，将所述的除草组合物用于选择性防除有用作物中的杂草，更优选地，所述有用作物为转基因作物或者基因组编辑技术处理过的作物。The application of a binary herbicidal composition in controlling weeds according to any one of claims 1-6, preferably, the herbicidal composition is used for selectively controlling weeds in useful crops, more Preferably, the useful crops are transgenic crops or crops treated with genome editing technology.
  8. 一种防治不想要的植物生长的方法，其包括将权利要求1-6任意一项所述的一种二元除草组合物施用于植物、植物部位、植物种子或植物生长的区域，优选地，将所述的除草组合物用于选择性防除有用作物中的杂草，更优选地，所述有用作物为转基因作物或者基因组编辑技术处理过的作物。A method for controlling unwanted plant growth, comprising applying a binary herbicidal composition according to any one of claims 1 to 6 to plants, plant parts, plant seeds or areas of plant growth, preferably, The herbicidal composition is used to selectively control weeds in useful crops, more preferably, the useful crops are transgenic crops or crops treated with genome editing technology.
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CN116849220A (en) 2023-10-10
CN114304165B (en) 2023-07-07

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