WO2022036738A1 - Procédé de traitement de fluide et dispositif de traitement de fluide - Google Patents

Procédé de traitement de fluide et dispositif de traitement de fluide Download PDF

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Publication number
WO2022036738A1
WO2022036738A1 PCT/CN2020/111881 CN2020111881W WO2022036738A1 WO 2022036738 A1 WO2022036738 A1 WO 2022036738A1 CN 2020111881 W CN2020111881 W CN 2020111881W WO 2022036738 A1 WO2022036738 A1 WO 2022036738A1
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Prior art keywords
fluid
separation
enrichment
pipeline
membrane
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PCT/CN2020/111881
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English (en)
Chinese (zh)
Inventor
李祥海
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上海心光生物医药有限责任公司
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Priority to EP20949945.8A priority Critical patent/EP4183432A1/fr
Priority to CN202080101880.5A priority patent/CN115697430B/zh
Publication of WO2022036738A1 publication Critical patent/WO2022036738A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3424—Substitution fluid path
    • A61M1/3437—Substitution fluid path downstream of the filter, e.g. post-dilution with filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3455—Substitution fluids
    • A61M1/3468—Substitution fluids using treated filtrate as substitution fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3479—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate by dialysing the filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3482—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate by filtrating the filtrate using another cross-flow filter, e.g. a membrane filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B01D61/146—Ultrafiltration comprising multiple ultrafiltration steps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/22—Controlling or regulating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/04—Specific process operations in the feed stream; Feed pretreatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/08—Specific process operations in the concentrate stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/16—Flow or flux control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/25—Recirculation, recycling or bypass, e.g. recirculation of concentrate into the feed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/10—Cross-flow filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2317/00—Membrane module arrangements within a plant or an apparatus
    • B01D2317/02—Elements in series

Definitions

  • the present application relates to the technical field of fluid processing, and in particular, to a fluid processing method, a fluid processing device, a circulating separation device, a circulating processing system, medical equipment, and a computer-readable storage medium.
  • the common way is to achieve by the method of membrane separation.
  • membrane separation In the separation of substances, the common way is to achieve by the method of membrane separation.
  • the filtration or concentration change of a specific component in various human tissue fluids such as blood and plasma is based on membrane separation.
  • membrane separation In water treatment, membrane separation is used. Separation realizes purification, and the mixed gas is purified by membrane separation.
  • the membrane separation technology especially the application in the medical field as an example, usually when filtering a specific component that needs to be separated, removed or changed in concentration, waste liquid that needs to be discarded is inevitably generated.
  • the membrane often contains other beneficial components, that is, the existing membrane separation technology is difficult to achieve directional or selective separation of specific components. Since the membrane separation process is accompanied by the loss of beneficial components such as glucose, amino acids, albumin, vitamins, hormones, electrolytes, etc., in order to avoid a large loss of beneficial components, the separation technology has many limitations in clinical application.
  • the purpose of the present application is to provide a fluid processing device, a circulating separation device and a fluid processing method, so as to solve the problem of poor selectivity in membrane separation existing in the prior art, doping with beneficial components and leading to beneficial effects. Continued loss of ingredients, lack of sustainability, etc.
  • the present application discloses a fluid processing method in a first aspect, comprising the following steps: introducing a fluid into an enrichment pipeline; wherein the enrichment pipeline includes a first section and a second Two stages, the inlet of the first stage is connected to at least one first inlet, and the outlet of the second stage is connected to the first stage; the target substance in the fluid is intercepted based on at least one first separation module; wherein , the first separation module has a first side and a second side separated by a first separation component, the opposite ends of the first side are respectively connected to the first section and the second section, and the second side is connected to at least one a first discharge port; based on at least one first driving device driving the fluid to circulate and flow in the enrichment pipeline at a preset flow rate to enrich the target substance, wherein the at least one first driving device is arranged in the first and control the dynamic balance of the total amount of fluid in the enrichment pipeline.
  • the present application also discloses a fluid processing method, comprising the following steps: introducing fluid into a separation pipeline based on at least one second separation module; wherein the separation pipeline has an inlet and an outlet; the second separation module The separation module has a first side and a second side separated by a second separation component, and opposite ends of the first side of the second separation module are respectively connected to at least one second inlet and at least one second outlet, and the second separation The opposite ends of the second side of the module are respectively connected to the inlet and the outlet of the separation pipe; based on at least one second driving device, the fluid in the separation pipe is driven to flow from the inlet to the outlet at a preset flow rate, so as to control the separation pipe The total amount of fluid in the circuit is dynamically balanced.
  • the present application also discloses a fluid processing device in a third aspect, comprising at least one circulation enrichment module, wherein the circulation enrichment module includes: an enrichment pipeline, including a first section and a second section; wherein, the The inlet of the first section communicates with at least one first inlet, and the outlet of the second section communicates with the first section; at least one first separation module includes a first separation component to separate the first separation module A first side and a second side are formed, wherein the opposite ends of the first side are respectively connected to the first section and the second section; the second side is connected to at least one first discharge port; at least one first driving device is set in the first section, and is used to drive the fluid circulation flow of the enrichment pipeline to control the dynamic balance of the total amount of fluid in the enrichment pipeline, so that the first separation module is in the enrichment cycle.
  • the target substance was enriched in the mode.
  • the present application further discloses a circulation separation device for fluid processing, the circulation separation device includes at least one circulation separation module, wherein the circulation separation module includes: a separation pipeline with an inlet and an outlet a second separation module, comprising a second separation assembly to separate the second separation module to form a first side and a second side, wherein the opposite ends of the first side of the second separation module are respectively connected to at least one second inflow port and at least one second discharge port, the opposite ends of the second side of the second separation module are respectively connected to the inlet and the outlet of the separation pipeline; at least one second driving device is arranged in the separation pipeline for The fluid in the separation line is driven to flow from the inlet to the outlet at a preset flow rate, so as to dynamically balance the total amount of fluid in the separation line in the circulating separation mode.
  • the circulation separation module includes: a separation pipeline with an inlet and an outlet a second separation module, comprising a second separation assembly to separate the second separation module to form a first side and a second side, wherein the opposite ends of
  • a fifth aspect of the present application further discloses a circulation treatment system, comprising at least one fluid treatment device according to any one of the embodiments provided in the third aspect of the present application or/and at least one of the fluid treatment devices provided in the fourth aspect of the present application
  • the circulating separation device described in the embodiment the pipeline system, including the fluid outlet pipeline and the fluid return pipeline.
  • the present application further discloses a medical device, comprising the circulatory processing system according to any one of the embodiments provided in the fifth aspect of the present application.
  • a computer-readable storage medium which stores at least one program, and when the at least one program is executed by a processor, implements any one of the embodiments provided in the first aspect of the present application.
  • the fluid processing method described above, or the fluid processing method described in any one of the embodiments provided in the second aspect of the present application is implemented.
  • the fluid processing method, fluid processing device, circulating separation device, circulating processing system and medical equipment of the present application have the following beneficial effects: intercepting the target substance in the fluid through the enrichment pipeline and the first separation module and making all the The target substance is cyclically enriched in the enrichment pipeline.
  • the fluid in the enrichment pipeline flows at a preset flow rate according to the drive of the first driving device, thereby ensuring that the fluid in the enrichment pipeline flows.
  • the total amount is dynamically balanced, so that the fluid treatment method of the present application is sustainable in the treatment, and can realize the collection or treatment of some components in the fluid, that is, the target substance, and the duration can be flexibly controlled.
  • the fluid drawn from the first discharge port can be connected to the processing module or storage space, avoiding the continuous loss of beneficial components during the separation or exchange of components in the fluid.
  • the processing device is connected to any pipeline that transports the fluid to be treated. To collect/remove the target substance while maintaining proper flow pattern and airtightness, the processing device is connected to any container storing the fluid to be treated, and to enrich/remove the target substance while maintaining the balance of the total amount of fluid.
  • FIG. 1 shows a schematic flowchart of the fluid processing method of the present application in an embodiment.
  • FIG. 2 shows a simplified schematic diagram of the circulating enrichment module of the present application in one embodiment.
  • Figure 3a shows a simplified schematic diagram of the circulating enrichment module of the present application in one embodiment.
  • Figure 3b shows a simplified schematic diagram of the circulating enrichment module of the present application in one embodiment.
  • Figure 4 shows a simplified schematic diagram of the circulating enrichment module of the present application in one embodiment.
  • Figure 5 shows a simplified schematic diagram of the circulating enrichment module of the present application in one embodiment.
  • 6a-6c are simplified schematic diagrams showing different working states of the circulating enrichment module of the present application in an embodiment.
  • FIGS. 7a-7b are simplified schematic diagrams showing different working states of the circulating enrichment module of the present application in an embodiment.
  • Figure 8 shows a simplified schematic diagram of the circulating enrichment module of the present application in one embodiment.
  • Figure 9 shows a simplified schematic diagram of the cascaded loop enrichment modules of the present application in one embodiment.
  • FIG. 10 shows a flowchart included in an embodiment of the fluid processing method of the present application.
  • Figure 11 shows a simplified schematic diagram of the cascaded cycle enrichment module and cycle separation module of the present application in one embodiment.
  • Figure 12 shows a simplified schematic diagram of the cycle separation module of the present application in one embodiment.
  • FIG. 13 shows a schematic flowchart of the fluid processing method of the present application in an embodiment.
  • Figure 14 shows a simplified schematic diagram of the cascaded loop separation modules of the present application in one embodiment.
  • Figure 15a shows a simplified schematic diagram of the cascaded cycle separation module and cycle enrichment module of the present application in one embodiment.
  • Figure 15b shows a simplified schematic diagram of the cascaded cycle separation module and cycle enrichment module of the present application in another embodiment.
  • FIG. 16 shows a flowchart included in an embodiment of the fluid processing method of the present application.
  • Figure 17 shows a simplified schematic diagram of the cascaded loop separation module and loop enrichment module of the present application in one embodiment.
  • FIG. 18 shows a simplified schematic diagram of the cyclic processing system of the present application in one embodiment.
  • FIG. 19 shows a simplified schematic diagram of the cyclic processing system of the present application in one embodiment.
  • FIG. 20 shows a simplified schematic diagram of the cyclic processing system of the present application in one embodiment.
  • first, second, etc. are used herein to describe various elements or parameters, these elements or parameters should not be limited by these terms. These terms are only used to distinguish one element or parameter from another element or parameter.
  • a first separation module could be referred to as a second separation module, and similarly, a second separation module could be referred to as a first separation module without departing from the scope of the various described embodiments.
  • the first separation module and the second separation module are both describing a separation module, but unless the context clearly indicates otherwise, they are not the same separation module.
  • a similar situation also includes a first separation assembly and a second separation assembly, or a first side and a second side.
  • A, B or C or “A, B and/or C” means “any of the following: A; B; C; A and B; A and C; B and C; A, B and C” . Exceptions to this definition arise only when combinations of elements, functions, steps, or operations are inherently mutually exclusive in some way.
  • Membrane separation is a process of separating, purifying and concentrating different components of a mixture by selective separation of membranes. It is an efficient, energy-saving and environmentally friendly separation method.
  • the filtering operation modes include vertical filtering (Normal Flow Filtration, NFF, also known as dead-end filtering), and tangential flow filtering (Tangential/Cross Flow Filtration, TFF).
  • NFF Normal Flow Filtration
  • TFF Tangential/Cross Flow Filtration
  • the liquid moves parallel (tangential to) the membrane surface, and the transmembrane pressure generated by the liquid drives part of the solution and small molecules across the filtration membrane, and retains part of the solution and larger molecules.
  • the liquid continuously flows on the surface of the filter membrane at a certain speed, and the surface of the filter membrane is washed and the particles deposited on the surface of the membrane are taken out of the TFF module.
  • the waste liquid in medical applications may contain glucose. , amino acids, albumin, vitamins, hormones, electrolytes, etc. Therefore, the consumption of beneficial components in filtration is a problem in many membrane separation technology application scenarios.
  • membrane separation based on steric hindrance effect as an example, it is essentially a process of retaining larger molecular weight or particle size components in the mixture and filtering out smaller molecular weight or particle size components, which is the directionality in the separation process.
  • the present application divides the application scenarios of membrane separation in terms of purpose, which can basically be summarized as the following two modes:
  • Mode A Large molecules are beneficial and small molecules are harmful, that is, small molecules are the components that need to be filtered out;
  • Mode B Large molecules are harmful and small molecules are beneficial, that is, large molecules are the components that need to be filtered out.
  • the B mode is more common, and it is also the use that was eventually developed, such as the process of filtration and sterilization, and the process of water treatment and purification.
  • the B mode is generally realized by dead-end filtration, but when the content of large molecular weight molecules is high, dead-end filtration is easy to block, so that the membrane cannot be used continuously or the upper limit of the liquid that can be processed is limited.
  • pretreatment by precipitation, distillation or other physical methods is generally required. If pretreatment cannot be performed, dead-end filtration cannot be used, such as when the mixture is blood, plasma, etc.
  • Mode A is more common in biological applications, such as the concentration and purification of recombinant proteins, as well as hemodialysis and plasma exchange, which are all processes to remove harmful or worthless small molecules in the system.
  • Traditional plasma exchange technology is a typical Problems in A mode. Because macromolecules are beneficial, tangential flow is generally used to facilitate the return of the trapped molecules to the original system, and to avoid the deposition of these components on the surface of the membrane, which affects the continuity of the treatment process.
  • beneficial components such as sugars, amino acids, vitamins, etc. The loss of a large amount of beneficial components makes the treatment process unsustainable.
  • plasma exchange equipment can be used in clinical scenarios such as renal diseases, cryoglobulinemia, and hyperacute or acute antibody-mediated rejection after kidney transplantation.
  • the sustainability of plasma is not high, and the clearance efficiency of pathogenic factors is also limited; in other scenarios, especially in traditional plasma exchange technology, by using plasma separation and delivering plasma substitutes to patients to achieve Blood is renewed, but the replacement fluid of plasma substitutes may cause allergic problems in the human body, which limits the feasible use scenarios.
  • DFPP double filtration plasmapheresis, double plasmapheresis technology
  • the plasma is usually filtered twice in the corresponding filtration system, and the plasma separation technology (that is, the separation of plasma, red blood cells, Platelets and leukocytes) and plasma component separation technology (ie, separation of specific components in plasma) two-stage filtration superposition, in plasma component separation, macromolecular pathogenic factors such as autoantibodies, immunoglobulins, immune complexes, inflammatory molecules Therefore, DFPP is usually used for severe diseases such as myasthenia gravis, Guillain-Barré syndrome, systemic lupus erythematosus (SLE), rheumatoid arthritis where the causative factor is macromolecular substances. , hyperlipidemia, severe acute pancreatitis, sepsis, but it is not suitable for clearing small and medium molecular pathogenic substances bound to albumin, and it is not suitable for clearing free medium
  • DFPP implements is the process of A+B mode.
  • the molecules that are intercepted between the two filtrations corresponding to the membrane pore size or molecular interception amount are the target molecules to be removed.
  • the tangential flow filtration technology can deal with the problems encountered in the B mode, which can effectively avoid the clogging problem caused by dead-end filtration.
  • the pulp rejection rate is generally a pulp rejection rate of 10% to 30%, and the pulp rejection rate is the ratio of the transport rate of the pulp rejection pump to the plasma separation pump; more specifically, in the double plasma exchange process, the pulp rejection flow rate is usually 2.5%.
  • Another example is the adsorption filtration purification system disclosed in the patent CN103263704A, in which a certain amount of plasma is obtained by separating human blood plasma, and the plasma is introduced into the purification unit to perform multiple adsorption processes to regenerate part of the waste plasma and reduce the amount of plasma required in plasma exchange.
  • waste liquid ie filtrate
  • waste liquid is generated at the high-flux filter used in the purification unit, so a certain percentage of regenerated plasma is obtained during the regeneration of waste plasma, while still Waste liquid is generated, so the problem of waste liquid in this application and the problem of continuous loss of beneficial components that may be extended from waste liquid still exist.
  • the replacement liquid is used to supplement the filtrate.
  • the exogenous substances in the aforementioned DFPP bring The risk of allergy still exists; at the same time, the high-pass filter in the adsorption filtration purification system is only suitable for the treatment of small-molecule plasma toxins, and the filtering effect of small-molecule toxins can be improved through multiple filtrations, and the effect achieved is to discard the toxins. A certain proportion of plasma in the plasma is regenerated; in addition, the adsorption filtration purification system cannot remove the pathogenic factors with large molecular weight in the blood, and the usage scenarios are limited, and it is difficult to collect or remove different components in the blood.
  • this application provides a solution for how to remove harmful macromolecules or components while avoiding the continuous loss of beneficial small molecules or components in the B application mode.
  • the present application provides a fluid treatment method, a fluid treatment device, and a separation and circulation device, which can be used to treat various fluids including medical scenarios, so as to enrich or remove (or change the concentration) directionally based on a preset treatment target.
  • the fluid treatment method and fluid treatment device of the present application can be used to perform a sustainable separation process, achieve a controllable removal effect, and effectively avoid or reduce the continuous loss of beneficial components.
  • large and small are relative concepts.
  • the determination of large and small can be based on the size of the molecules or substances themselves, such as particle size or weight, such as lipoproteins compared to amino acids, the former is a large molecule and the latter is a small molecule.
  • the large and small can be due to the molecular size or molecular weight relative to the molecular cut-off or pore size of the membrane, for example, for a separation module with a 0.5 ⁇ m pore size, cells and platelets are large molecules, while plasma proteins are small molecules; and for a 10kD porous membrane, lipoprotein, albumin and cells are macromolecules, while glucose, amino acids, etc. are small molecules, that is, the macromolecules, macromolecular components, small molecules, and small molecules described in this application Components, etc., can be relative concepts that describe molecules that are retained and filtered based on membranes.
  • the present application provides a fluid processing method, comprising the following steps: introducing a fluid into an enrichment pipeline; wherein the enrichment pipeline includes a first section and a second section, and the first section has a The inlet is communicated with at least one first inlet; based on at least one first separation module, the target substance in the fluid is intercepted; wherein, the first separation module has a first side and a second side separated by the first separation component, The opposite ends of the first side are respectively connected to the first section and the second section, and the second side is connected to at least one first discharge port; the fluid is driven in the enrichment pipeline based on at least one first driving device Circulating flow at a preset flow rate to enrich the target substance, wherein the at least one first driving device is arranged in the first section and controls the dynamic balance of the total amount of fluid in the enrichment pipeline.
  • the target substance is determined based on a preset target for fluid processing, and the target substances enriched and circulated in different enrichment pipelines may be of the same type or the same substance component Or molecules, which can also be different substances, and the specific composition of the target substance can be changed based on the fluid composition and the predetermined separation purpose.
  • the target substance is, for example, cells, bacteria, microorganisms, proteins, lipoproteins, antibodies, DNA, etc.; in the fluid processing method, the target substance is the substance trapped in the pipeline , that is, when the fluid is processed by the fluid treatment method provided in this application, any substance that is trapped and enriched in the enrichment pipeline can be regarded as the target substance; in practical applications, the target substance can be collected
  • the target substance can be collected
  • the type and use of the target substance are not limited in this application.
  • FIG. 1 shows a schematic flowchart of an embodiment of the fluid processing method of the present application.
  • step S10 the fluid is introduced into an enrichment pipeline; wherein, the enrichment pipeline includes a first section and a second section, the inlet of the first section is connected to at least one first inlet, and the first section The outlet of the second section communicates with the first section.
  • the communication refers to a mechanical structure capable of circulating fluid, and in some occasions, the communication is often referred to as communication or connection.
  • FIG. 2 shows a simplified schematic diagram of the enrichment pipeline of the fluid processing method in one embodiment.
  • the fluid contains the target substance, and in certain embodiments, the fluid includes but is not limited to blood, plasma, serum, body fluid, tissue fluid, washing fluid, dialysate, recombinant protein solution, cell culture fluid, microbial culture fluid, pharmaceutical and a mixture of one or more of medical water, medicinal liquid, fluid food, animal and plant extracts, natural water, industrial wastewater, reclaimed water, light oil, methane, and liquefied gas; in some examples, the The fluid can also be a material component obtained by processing, eg, filtering, a fluid such as blood, plasma, etc.; in other examples, the fluid can also be a gas mixture, such as a gas mixture including methane.
  • the fluid treatment method of the present application can be applied to the treatment of different types of fluids.
  • the fluid has different material components, such as the fluid has a difference in selective permeation when it is transported in a separation membrane.
  • the components and certain fluidity are sufficient to enable the separation process, such as the above-mentioned liquid mixture or gas mixture, and the fluid may be other solid-liquid mixed phase fluid or colloid, which is not limited in this application.
  • the first section 111 and the second section 112 of the enrichment pipeline 11 can be based on a certain connection relationship, so that the direction of the liquid flow in the enrichment pipeline 11 can form a cycle, and the outlet of the second section 112 is communicated
  • the first section 111 after the fluid enters the first section 111 from the first inlet, it can pass through the first separation module 12 , and then flow to the second section 112 and flow from the outlet of the second section 112 .
  • a flow cycle can be formed.
  • the path graph constituting the cycle can be determined based on the first segment 111 and the second segment 112, for example, in the example shown in FIG. 2, it is a rectangle.
  • the path graph can include multiple polylines such as "Convex" shape, or include arcs, such as arcs, in actual scenarios, the first segment 111 and the second segment 112 communicate and transmit fluids.
  • the first segment The pipe diameter, material, and path of 111 and the second section 112 can be adjusted accordingly, so the method described in this application does not limit the shape and model of the pipe path.
  • the pipeline materials of the first and second sections can be set to special materials corresponding to fluids.
  • the first and second sections or a section or part of them can be set to blood Special pipelines, special pipelines for peristaltic pumps, special pipelines for corrosive liquids, high biocompatibility pipelines, etc.; taking the application of the fluid processing method in medical scenarios as an example, the first and second sections are
  • pipeline materials include but are not limited to soft polyvinyl chloride plastics, high-performance polyolefin thermoplastic elastomers (TPE), nano-biomedical materials, and resin materials.
  • the inlet of the first section is connected to at least one first inlet, and the first inlet is used as the inlet for conveying fluid to the enrichment pipeline, and the first inlet can be set to at least one
  • the introduction of the fluid into the enrichment pipeline is not limited in this application.
  • the multiple first inlets can respectively introduce fluids with different substance components into the enrichment pipeline, for example, from a first inlet
  • the immunoglobulin-filtered plasma is introduced, and the rheumatoid factor-filtered plasma is introduced in another first inlet.
  • step S11 the target substance in the fluid is intercepted based on at least one first separation module; wherein, the first separation module has a first side and a second side separated by a first separation module, and the first side The opposite ends of the duct are respectively communicated with the first section and the second section, and the second side communicates with at least one first outlet.
  • the first separation module 12 can be used to connect the enrichment pipeline 11 and contact the fluid, so as to realize the separation of specific components in the fluid.
  • the retained target substance may be a fluid component that needs to be retained, or a component that needs to be removed from the fluid. That is, the enrichment pipeline 11 can be used to enrich beneficial components in the fluid, and can also be used to enrich the components to be removed in the fluid.
  • the first separation module 12 is a relatively closed cavity structure, that is, the two ends of the first side of the first separation module 12 are respectively connected to the first section 111 and the second section 112.
  • a closed cavity is formed on the first side of the first separation module 12;
  • the first outlet that communicates with the two sides is closed, and the second side of the first separation module 12 also forms a closed cavity.
  • the relatively closed structure It can form a sterile environment or reduce bacterial, microbial, viral and other infections.
  • the fluid processing method of the present application reduces the disturbance of the external environment when the fluid circulates in the enrichment pipeline 11 and is processed by forming a relatively closed circulation environment, so that the reliability of the processing process is increased.
  • the first separation module 12 has a first separation component, the first separation component can contact the fluid and selectively permeate specific material components in the fluid; the first separation component separates the first separation module 12 to The fluid passing through the first separation component and the intercepted fluid may be located on two sides formed by the separation of the first separation component, respectively.
  • the fluid in the enrichment pipeline 11 can flow from the first section 111 to the second section 112 via the first separation module 12 , and return to the first section from the outlet of the second section 112 At the same time, the components other than the target substance in the fluid pass through the first separation module in the first separation module 12 and reach the second side of the first separation module 12, thereby The enrichment pipeline 11 can be left through the first discharge port, that is, the separation effect of the target substance in the fluid is achieved.
  • the separation effect is formed after the fluid passes through the first separation module and is trapped on the first side of the first separation module and the fluid on the second side of the first separation module
  • At least one component (eg a filterable component) in the fluid leaving the circulation creates a concentration difference rather than an absolute separation or scavenging effect, eg components in the fluid on the second side of the first separation module may also be present
  • a very small amount of the target substance may also leave the circulation and flow to the second side of the first separation module, but there is at least one component in the second side of the first separation module. Concentrations are different on both sides of a separation module.
  • the first side of the first separation module 12 and the second side of the first separation module 12 are used to distinguish the fluid components passing through the first separation component from the positions of the intercepted fluid, and the first side is different from the position of the intercepted fluid.
  • the positional relationship of the second side is determined by the cavity structure of the first separation module 12 and the structure of the first separation assembly. For example, when the first separation component is a planar structure and is laterally arranged in the first separation module 12, the first side and the second side are the upper side and the lower side respectively; or when the first separation component The planar structure is vertically arranged in the first separation module 12, and the first side and the second side are the left side and the right side, respectively.
  • the first separation component is a hollow fiber structure and is placed in the first separation module 12, and the first side and the second side are the inner side and the outer side of the hollow fiber, respectively.
  • the second side may share a cavity.
  • the cavity in the first separation module that communicates with the first section and the second section of the enrichment pipeline is the first side, and the cavity in the first separation module is the first side.
  • the other cavity is the second side; in an example, when the first separation module includes a plurality of cavities, for example, the first separation module has a plurality of first separation components in the form of plate membranes to separate the The first separation module is divided into a plurality of cavities, the plurality of cavities connecting the first section and the second section is the first side, and the rest of the cavities are the second sides.
  • the first separation component is a structure or material with selective permeability to some components in the fluid, such as a filter, a filter membrane, a porous material, and the like.
  • the first separation component may be configured as a porous membrane, a reverse osmosis membrane, or a gas separation membrane.
  • the first separation component is a porous membrane, wherein the porous membrane comprises a microfiltration membrane, an ultrafiltration membrane, or a nanofiltration membrane.
  • the average pore diameter or molecular weight cutoff (MWCO for short) of the porous membrane or reverse osmosis membrane is related to the target substance.
  • MWCO molecular weight cutoff
  • a porous membrane suitable for retaining the target substance is selected. For example, when the target substance to be retained in the fluid has a particle size of 10 nm (ie, 0.01 ⁇ m), Then the corresponding separation membrane can use nanofiltration membrane or reverse osmosis membrane to achieve the interception of target substances.
  • the specific type of the separation membrane can be determined based on the difference in physical and chemical properties of each component of the fluid and the target substance, such as: reverse osmosis membrane (average pore size: 0.0001-0.001 ⁇ m), nanofiltration membrane (average pore size: 0.001-0.01 ⁇ m) ⁇ m), ultrafiltration membrane (average pore size 0.01-0.1 ⁇ m), microfiltration membrane (average pore size 0.1-10 ⁇ m), electrodialysis membrane, permeation gasification membrane, liquid membrane, gas separation membrane, electrode membrane, etc.
  • reverse osmosis membrane average pore size: 0.0001-0.001 ⁇ m
  • nanofiltration membrane average pore size: 0.001-0.01 ⁇ m) ⁇ m
  • ultrafiltration membrane average pore size 0.01-0.1 ⁇ m
  • microfiltration membrane average pore size 0.1-10 ⁇ m
  • electrodialysis membrane permeation gasification membrane, liquid membrane, gas separation membrane, electrode membrane, etc.
  • the separation membrane is a high-purity polymer, chemically inactive, and has good hemocompatibility and histocompatibility.
  • the separation membrane achieves the retention, filtration or exchange of target species through steric hindrance effect, Donan effect or electrostatic effect, adsorption, diffusion, charge repulsion effect, pore effect, or dissolution.
  • the substance components selectively permeated by the separation membrane are related to the type of the separation membrane and the composition of the target substance.
  • a corresponding separation membrane can be set based on the predetermined target substance composition to process the fluid.
  • the separation membrane is, for example, a porous membrane with an average pore size smaller than the particle size of the pathogenic factor molecule, so as to separate the macromolecular pathogenic factor from the macromolecular pathogenic factor.
  • the first A separation component can be set as a nanofiltration membrane to realize filtration; for another example, when the fluid is a gas mixture, the corresponding first separation component can be set as a gas separation membrane to allow a specific gas in the fluid to pass through the gas separation membrane, So as to realize the separation and retention of different gas components.
  • the treatment of the target substance may be determined as retention based on the fluid composition and the target substance composition, and the average pore size or retention of the separation membrane suitable for retaining or filtering the target substance is determined based on the molecular size of the target substance.
  • the molecular weight is used to set the separation membrane used in the actual scene; in other examples, when determining the specific type of the separation membrane, the Daunan effect, adsorption, dissolution, etc. Set the membrane to achieve a preset separation effect in .
  • the pore size and type of the corresponding separation membrane can be determined on the basis that the first separation component can intercept more than 90% of the target substance, or the first separation component can be adjusted to the target based on higher separation effect requirements.
  • the rejection rate of substances is set to be above 95% or even above 99% to determine the corresponding pore size and type of separation membrane.
  • the separation membrane may include, for example, a symmetric membrane, an asymmetric membrane, a composite membrane, a multi-layer composite membrane, and the like.
  • the first separation component can also be configured as separation membranes with different geometric shapes to adapt to different fluids or achieve different filtering effects.
  • the first separation module includes one or more of flat membranes, tubular membranes, rolled membranes, spiral membranes, and hollow fiber membranes.
  • the flow angle of the fluid relative to the separation membrane can be set to different angles, such as 0° to 90°.
  • the flow angle of the fluid relative to the separation membrane is 0°, that is, the fluid flows parallel to the surface of the separation membrane. , such as common tangential flow filtration; when the flow angle of the fluid relative to the separation membrane is 90°, that is, the fluid flows in a direction perpendicular to the membrane surface, such as conventional dead-end filtration (also called vertical filtration).
  • the flow channels in the first separation module can be arranged in a folded and reciprocating form, for example, by folding a flat membrane to increase the contact surface area between the fluid and the flat membrane, correspondingly the flow channels are arranged It is folded and reciprocated to match the structure of the separation membrane, so as to ensure that the separation membrane separates the first separation module to form a first side and a second side.
  • the first separation module is a Tangential/Cross Flow Filtration Module (TFFM for short).
  • TFFM Tangential/Cross Flow Filtration Module
  • tubular membranes or hollow fiber membranes may be used in the tangential flow filtration module to achieve filtration, In this setting, increasing the surface area of the fluid in contact with the separation membrane can increase the filtration efficiency.
  • the tangential flow filtration module can use existing tangential flow filtration membrane packages, such as the Pellicon cartridge ultrafiltration membrane package of MERCK company, the leukocyte removal filter, virus removal filter of Asahi Kasei company, LEOCEED dialyzer, membrane type plasma separator, BRAUN plasma separator, etc. It should be noted that, on the one hand, the tangential flow filtration module can be used in different fields to achieve different separation effects, for example, it can be used to achieve material Collection (retaining materials in the enrichment pipeline and circulating collection), industrial wastewater treatment, etc.
  • the tangential flow filtration module is based on the The corresponding membrane pore size or molecular weight cut-off and the membrane geometry are determined for the purpose of filtration or retention of target substances in the fluid, and are not limited to the foregoing examples.
  • one or more first separation modules may be arranged in the enrichment pipeline, wherein the opposite ends of the first side of each first separation module are respectively connected to the enrichment pipeline, The target substance retained by the first separation component can then be circulated in the enrichment pipeline.
  • the number of the first separation modules may be comprehensively determined based on factors such as the diameter of the enrichment pipeline, the length of the enrichment pipeline, the separation efficiency of the first separation module, and the economic cost.
  • step S12 based on at least one first driving device, the fluid is driven to circulate and flow in the enrichment pipeline at a preset flow rate to enrich the target substance, wherein the at least one first driving device is provided in the first section and control the dynamic balance of the total amount of fluid in the enrichment pipeline.
  • the first driving device 13 includes but is not limited to a peristaltic pump, a pressure pump, an electric field, a heater, a hydraulic pump, or a vacuum pump, and is used to provide power to the fluid in the enrichment pipeline 11 to make the fluid conform to the preset It flows in the same flow direction, that is, flows from the first section 111 through the first separation module 12 and then enters the second section 112, and flows from the outlet of the second section 112 to the first section 111 to form a dynamic cycle.
  • the driving device should not directly contact the liquid, but only applies pressure to the pipeline and drives the liquid to flow, and the driving device can be configured as a peristaltic pump.
  • the preset flow rate may be jointly determined based on the safety of the application scenario, the separation effect of the separation by the first separation module 12, the economy of the equipment, and other factors. For example, in a treatment involving blood, when the fluid at the first inlet is human blood, the flow rate of the fluid drained at the first inlet needs to be controlled within a preset range to ensure patient safety.
  • the enrichment of the target substance can be achieved when the fluid circulates in the enrichment pipeline 11 at a preset flow rate.
  • the enrichment pipeline 11 when the enrichment pipeline 11 processes the fluid in the cyclic enrichment mode, the total amount of fluid in the enrichment pipeline 11 is dynamically balanced; in the cyclic enrichment mode , the first inlet keeps introducing the fluid to be treated into the enrichment pipeline 11, and the fluid flows in the enrichment pipeline 11 according to the preset flow direction and intercepts the target substance through the first separation module 12 during the circulating flow process, At the same time, the fluid from which the target substance has been filtered out through the first separation component is drawn out from the first discharge port.
  • the fluid in the enrichment pipeline can be realized based on the power provided by the first driving device 13 . 11, and at the same time, the enrichment pipeline 11 continuously introduces fluid from the first inlet to gradually increase the retained target substance, thereby realizing the enrichment of a specific component, ie, the target substance.
  • the at least one first driving device 13 is arranged in the first section 111 and controls the dynamic balance of the total amount of fluid in the enrichment pipeline 11 .
  • the first section 111 is the upstream of the first separation module 12 according to the direction of fluid circulation in the enrichment pipeline 11 .
  • the first driving device 13 can be used to control the flow rate of the fluid passing through the first separation module 12 . It should be understood that the first driving device 13 can drive the fluid in the pipeline at different positions in the enrichment pipeline 11 , and the flow rate of the first driving device 13 may be caused by factors such as pipeline resistance, temperature, and pressure in accordance with the flow direction of the fluid. The fluid velocity changes.
  • the first driving device 13 is provided at the first section 111 , that is, upstream of the first separation module 12 , and can be used to control the flow rate at the first separation module 12 .
  • the fluid flow rate taking the embodiment in which the first separation component is a separation membrane as an example, the flow direction angle of the fluid relative to the separation membrane can be set to different angles, such as 0° to 90°, and the fluid relative to the separation membrane
  • the flow rate of 1 is related to the separation effect, and the fluid treatment method of the present application can control the separation effect by setting the position of the first driving device 13 .
  • the separation effect includes but is not limited to membrane flux, separation rate, scavenging effect (scavenging rate) of small molecular substances, and retention rate of macromolecular substances.
  • the upstream is used to indicate the flow direction of the fluid between the first section 111 and the first separation module 12, that is, when the first section 111 is located in the first separation Upstream of the module 12 , the fluid flow direction is from the first section 111 to the first separation module 12 .
  • the at least one first driving device 13 controls the flow rate of the first section 111 to be above a preset threshold, so that the target substance flows from the outlet of the first section 111 to the second section Entrance to 112.
  • the flow direction of the fluid is parallel to the separation membrane in the TFFM.
  • a pressure difference perpendicular to the membrane surface is generated on both sides of the membrane to
  • the small molecules in the driving fluid pass through the separation membrane and reach the second side of the first separation module 12.
  • the small molecules passing through the separation membrane can be led out of the enrichment pipeline 11 through the first discharge port, and are trapped at the same time.
  • the macromolecules are washed away from the membrane surface by the fluid momentum and continue to circulate in the enrichment pipeline 11 .
  • the pressure difference between the two sides of the membrane in the TFFM is related to the preset threshold.
  • the at least one first driving device 13 controls the flow rate of the first section 111 to be above a preset threshold, that is, it can be used to control the pressure difference on both sides of the separation membrane to achieve the separation effect, and can be used to prevent polymerization to ensure the Sustainability of circulation in enrichment line 11 .
  • the preset threshold is related to at least one of fluid composition, fluid temperature, membrane structure, membrane material, cavity structure of the first separation module 12 , and the diameter of the enrichment pipeline 11 .
  • the fluid flow rate at the first separation module 12 is related to different parameters, for example, based on the properties of different fluids such as fluid density and viscosity, and the boundary layer shape of the fluid at the first separation module 12 such as the surface shape of the separation membrane ( That is, the membrane structure) and the cavity structure of the first separation module 12, the interaction force between the fluid and the separation membrane, such as the membrane surface roughness determined by the membrane material, and the attractive force between the fluid, are determined by the cavity of the first separation module 12.
  • the flow rate relationship between the first separation module 12 and the enrichment pipeline 11 determined by the body structure and the diameter of the enrichment pipeline 11, the fluid flow rate at the first separation module 12 may change; here, the preset The threshold is used to determine the fluid flow rate to the first separation module 12, and the preset threshold can be used as the initial flow rate at the first separation module 12, based on the initial flow rate and the aforementioned fluid flow rate at the first separation module 12 can determine the flow rate of the fluid in the first separation module 12 based on the control of the preset threshold to generate a pressure difference to achieve separation and prevent the trapped macromolecular substances, that is, the target substances from being blocked on the membrane surface, thereby , the target substance flows from the outlet of the first section 111 to the inlet of the second section 112 .
  • the preset The threshold is used to determine the fluid flow rate to the first separation module 12, and the preset threshold can be used as the initial flow rate at the first separation module 12, based on the initial flow rate and the aforementioned fluid flow rate at the first separation module 12 can determine the
  • the second segment is further provided with the first drive means.
  • the first driving device provided in the first section can be used to control the fluid flow rate at the first separation module
  • the second section is also provided with the first driving device device
  • a plurality of first driving devices in the enrichment pipeline can cooperatively control the fluid flow rate in the enrichment pipeline to determine the flow rate at different positions in the enrichment pipeline; in this example, the first drive devices
  • Both the segment and the second segment are provided with a first drive device.
  • the pipeline connecting the first inlet and the first separation module can be regarded as the first segment.
  • the first inlet can be connected to the first section and the second section at the same time or the first section and the second section are respectively connected to a first inlet, that is, as shown in FIG.
  • the second section 112 can be determined based on the fluid circulation direction in the circulating enrichment mode, that is, the first section 111 is located upstream of the first separation module 12, and the enrichment pipeline is controlled by the first driving device 13 After the circulation direction in 11 is changed, the positions of the first segment 111 and the second segment 112 are also changed accordingly.
  • the fluid processing method of the present application is such that the total volume or total velocity of fluid introduced into the enrichment line from the first inlet and the enrichment drawn from the first outlet The total volume or total velocity of the fluid in the pipeline is equal, cyclically enriching the target substance in a sustainable manner.
  • the total volume or total velocity of the fluid introduced into the enrichment pipeline by the first inlet is equal to the total volume or total velocity of the fluid drawn out of the enrichment pipeline from the first discharge opening, the The total amount of fluid in the enrichment pipeline is in dynamic equilibrium.
  • the total volume of fluid can also be used as volume flow, the total velocity can also be used as average velocity, or the first inflow can be controlled
  • the fluid mass flow at the port is equal to that of the first discharge port.
  • the enrichment cycle when the enrichment cycle is operated alone, while the liquid is filtered out through the first separation module, a negative pressure will be formed inside the enrichment cycle, which will drive the inflow of the liquid at the first inlet, and this driving force will It varies with the filtration efficiency of the first separation module, which means that if the fluid to be treated flowing into the first inlet is not a constant flow rate, but a dynamic flow rate or a non-dynamic liquid, the enrichment cycle can be filtered according to its own. This means that if the filtration efficiency of the first separation module decreases due to the excessive concentration of target molecules in the enrichment cycle, the inflow of the liquid to be treated will also decrease, so as to passively maintain the above dynamic equilibrium.
  • the fluid flow rate is controlled by the first driving device to ensure the dynamic balance of the total amount of fluid in the enrichment pipeline, and the pressure in the enrichment pipeline in the cyclic enrichment mode can maintain a constant value or a fluctuation range determined by the constant value , the problems of pipeline rupture, negative pressure suction, and fluid component destruction, such as rupture of red blood cells in blood, caused by changes in the pressure in the pipeline can be avoided, and the circulating enrichment mode is thus sustainable.
  • the pressure in the enrichment pipeline is related to the total amount of fluid in the pipeline. For example, when the fluid in the enrichment pipeline continues to decrease, negative pressure is easily formed in the relatively closed structure of the enrichment pipeline. If the fluid in the manifold continues to increase, the pressure in the enrichment pipeline will increase. The negative pressure or excessive pressure will have a negative impact on the separation effect of the fluid treatment and the safety of the enrichment pipeline. Taking medical applications as an example, when the The fluid is blood, and if the pressure in the enrichment pipeline is too high, the pipeline ruptures or the first separation component is damaged, which may lead to treatment failure and even endanger the health of the patient.
  • the first driving device can also ensure that the pressure in the enrichment pipeline is in a preset state, or adjust the pressure in the enrichment pipeline to a preset state while providing the power for fluid circulation.
  • the first section is provided with at least one first driving device, and on this basis, any pipeline and position in the enrichment pipeline can also be set
  • the first driving device is used to coordinately control the fluid flow rate of each position in the enrichment pipeline and the overall balance state;
  • the number and position of the first driving devices are determined by setting the flow rate and the like.
  • the fluid circulation in the enrichment pipeline is controlled and the dynamic balance of the total amount of fluid is maintained, and the corresponding first separation is determined based on the fluid components and the target substance.
  • the fluid treatment method can realize the continuous collection of target substances in the enrichment pipeline, that is, it can be used to realize the solution of how to continuously treat the harmful macromolecules with huge content in the aforementioned B mode.
  • the enrichment pipeline can be used not only for circulating fluid, but also as a container for enriching target substances, and in practical scenarios such as medical applications, it can be used to effectively simplify the equipment structure or reduce equipment space for executing the fluid processing method of the present application , correspondingly, a simple device that is easy to use or carry or wear can be formed; in addition, the cycle enrichment time can be determined based on the preset processing goals of the fluid, such as the separation effect, the collection amount of the target substance, etc., that is, enrichment The number or duration of cycles in the circuit can be controlled based on preset treatment goals.
  • the separation efficiency is adjusted by controlling the ratio of the amount of fluid introduced into the enrichment pipeline per unit time to the total amount of fluid in the enrichment pipeline.
  • the amount of fluid introduced into the circulation per unit time is the flow rate of the fluid to be treated at the inlet of the circulation.
  • the enrichment line In an equilibrium state, the enrichment line remains full, and the total volume of the total amount of fluid in the corresponding enrichment line remains relatively constant.
  • the average residence time of the fluid to be treated in the enrichment pipeline can be determined, and correspondingly, the residence time of the fluid to be treated in the enrichment pipeline can be determined. cycle time in .
  • the accommodating space of the enrichment pipeline in the cycle is a relatively certain value, when the enrichment pipeline is fed to the enrichment pipeline.
  • the first aspect of the present application further includes the step of pre-processing or re-processing the fluid by at least one processing module, wherein the pre-processing or re-processing includes filtration, adsorption, heating, catalysis, At least one of enrichment, concentration, chemical treatment, optical treatment, and electrical treatment.
  • the processing modules are, for example, an adsorption device, an extraction device, an ion exchange processing device, a centrifugal device, a filtering device, a heating device, and the like.
  • the processing module pretreats the fluid, ie, processes the initially obtained fluid, so as to introduce the processed fluid into the enrichment pipeline through the first inlet.
  • the fluid processed by the processing module is connected to the first inlet of the enrichment pipeline, and the processing module is to perform pretreatment.
  • the reprocessing of the fluid by the processing module is processing the target substance in the enrichment pipeline; or the processing of the fluid on the second side of the first separation module by the processing module is reprocessing.
  • the type of preprocessing or reprocessing performed by the processing module may be determined based on processing needs. For example, when the target substance retained in the enrichment pipeline is a fluid component that needs to be filtered out, In order to meet the needs of purification of beneficial components, the processing module can concentrate the fluid drawn from the first discharge outlet.
  • FIG. 3a a simplified schematic diagram of the enrichment circuit in one embodiment is shown. Please refer to FIG. 3a and FIG. 3b in combination.
  • FIG. 3b is a simplified schematic diagram of the enrichment pipeline in an embodiment in which the processing module of FIG. 3a is a separation device.
  • the processing module 30 is a separation device, through which the fluid is pretreated, and the separation fluid containing the target substance passing through the separation device is introduced into the enrichment pipeline 11 Reprocess.
  • the separation device for example, pretreats the fluid by means of precipitation, centrifugal separation, ion exchange, membrane separation, etc. to achieve impurity removal.
  • the enrichment line 11 processes the fluid to enrich the target substance in the separation fluid.
  • the initially obtained whole blood is separated by the separation device to obtain plasma and cell components, and the target substance in the plasma is enriched based on the enrichment pipeline 11 .
  • the target substance is a pathogenic factor
  • the filtered plasma on the second side of the first separation module and the cell components obtained by the separation of the processing module are pooled to flow back to the human body, and the human blood circulation can be changed during this cycle enrichment process.
  • the separation device is a porous membrane
  • the pore size or molecular cut-off of the separation device and the separation membrane of the first separation module 12 is determined based on the particle size or molecular weight of the target substance, that is, the porous membrane through which the target molecule can be filtered into the rich
  • the collection cycle can be retained by the porous membrane of the first separation module 12 and enriched in the enrichment cycle.
  • the selection of the membrane pore size is similar to that of the DFPP process.
  • the first inlet and the first outlet are connected to the same storage part, wherein the storage part includes a fluid storage part device, container, or human body.
  • FIG. 4 is a simplified schematic diagram of the enrichment pipeline in one embodiment.
  • the storage part 16 is only used to realize the storage or communication function of the fluid introduced by the first inlet port and the fluid drawn out from the first discharge port. Therefore, the storage part 16 may be a container Or storage space, in a specific application scenario, it can also be the blood circulation of the human body, which is not limited in this application.
  • the first inlet and the first outlet are connected to the same storage device or container, where the first drive means controls the flow of water in the enrichment pipeline.
  • the dynamic balance of the total amount of fluid correspondingly, the dynamic balance of the total amount of fluid in the storage device or container; in the circulating enrichment mode, the fluid is introduced into the enrichment pipeline from the storage device or container and is enriched
  • the target substance is enriched in the pipeline, and the fluid separated from the target substance component is returned to the storage device or container through the second side of the first separation module, and the enrichment is continuously circulated, then the target substance is contained in the fluid in the storage device or container.
  • the substance is gradually reduced while the total amount of fluid remains unchanged, the collection of specific target substance components is achieved without generating waste liquid, and the total amount of fluid in the storage device or container remains unchanged, the cyclic enrichment process can continue.
  • the fluid when the storage part is a human body, can be blood, plasma, serum, tissue fluid or other body fluids of the human body.
  • the first inlet and the first row The connection relationship between the flow port and the human body can be a direct connection or an indirect connection.
  • the direct connection is that the fluids in the first inlet and the first discharge port can be connected to the circulatory system of the human body, and the indirect connection is the first inflow.
  • the port or/and the first outflow port are connected to a processing module, and the processing module is connected to the human circulatory system. The port is then connected to the plasma obtained from the separation.
  • the pathogenic factors to be filtered out such as low-density lipoprotein
  • the beneficial components in the plasma can be continuously separated to On the second side of the first separation module, waste plasma can be avoided in the process of enriching the target substance, which effectively solves the problem of continuous loss of beneficial components.
  • the enrichment pipeline further includes an exhaust gas inlet, which is provided in the first section or/and the second section, and is used to adjust the enrichment pipeline Air pressure inside the road.
  • the exhaust gas port can be used to connect the enrichment pipeline to external atmospheric pressure or to a gas storage device, and the internal air pressure of the enrichment pipeline can be adjusted by performing gas exchange through the exhaust gas inlet.
  • the exhaust gas inlet can be selectively opened or closed.
  • the exhaust gas inlet when the fluid is in a circulating enrichment mode in the enrichment pipeline, the exhaust gas inlet can be set to a closed state to Keep the inside of the pipeline in a relatively airtight state; in another example, the first inlet is closed, and the enrichment pipeline performs the concentration and circulation treatment of the fluid, and the total amount of fluid in the enrichment pipeline is reduced.
  • the exhaust gas inlet can be set to an open state to keep the air pressure in the enrichment pipeline equal to the external atmospheric pressure to avoid the formation of negative vacuum pressure; in another example, in the circulating enrichment mode, all The exhaust gas inlet can be set to open to connect to the gas storage device, which can be used in practical scenarios to prevent the fluid in the enrichment pipeline from being infected, polluted, or reacting with gas components in the air during the enrichment process. In medical applications, a sterile environment can be ensured in the enrichment pipeline by controlling the gas composition stored in the gas storage device.
  • a sterile filter membrane is provided at the exhaust gas inlet, and the enrichment pipeline performs gas exchange with external gas such as air through the sterile filter membrane, thereby increasing the pressure inside the enrichment pipeline.
  • the enrichment pipeline performs gas exchange with external gas such as air through the sterile filter membrane, thereby increasing the pressure inside the enrichment pipeline.
  • the first section or/and the second section are further provided with a flow channel adjustment device, which is used to adjust the flow direction of the fluid in the enrichment pipeline.
  • the flow channel adjustment device can be used to switch the working mode of the enrichment pipeline, for example, to switch the enrichment pipeline from the circulation enrichment mode to the concentration circulation mode or the cleaning mode.
  • the flow channel adjustment device can adjust the flow direction of the fluid in the enrichment pipeline by at least one of the following ways:
  • Adjust the fluid flow direction by adjusting the opening state of the first inlet or/and the first outlet;
  • the fluid flow direction is adjusted by adjusting the open state of at least one adjustment pipe connected to the enrichment pipe.
  • the flow channel adjustment device includes a device provided on the first inlet or/or and the pipeline switch of the first outlet, in an implementation manner, the first inlet is provided with a pipeline switch, which is used to switch the fluid in the enrichment pipeline to concentrate in a closed state cycle mode.
  • the pipeline switch can be configured as, for example, a pipeline clamp, an on-off valve, a water flow switch provided with a sensor, etc., which is not limited in this application.
  • the pipeline switch is used to control the opening or closing of the first inlet.
  • the enrichment pipeline continuously replenishes fluid and discharges the fluid separated by the first separation module.
  • the target substance can be enriched in the enrichment pipeline; when the pipeline switch controls the first inlet to close, the first driving device controls the fluid in the enrichment pipeline to continue to circulate, and the first separation module first
  • the fluid after separation is drawn out from the two sides. In this state, the total amount of fluid in the enrichment pipeline decreases, and the corresponding concentration of the target substance increases, that is, the fluid is switched to the enrichment cycle mode in the enrichment pipeline.
  • a high concentration of the target substance can be obtained by processing the fluid based on the concentrated circulation mode.
  • the target substance is platelets
  • the enrichment cycle is used to concentrate the platelets without going through the separation process in vitro, which can avoid repeated processing in vitro and waste of blood.
  • the platelets obtained through the concentration cycle can be used for cardiac surgery, wound treatment and other applications .
  • the fluid flow direction is adjusted by adjusting the open state of at least one adjustment pipe connected to the enrichment pipeline.
  • the flow path adjustment device includes at least one adjustment pipe and a pipe corresponding to the adjustment pipe switch, thereby forming a cleaning liquid inlet and a waste liquid outlet.
  • FIGS. 6 a to 6 c are simplified schematic diagrams of the enrichment pipeline 11 and the flow channel adjustment device 14 in different circulation modes in an embodiment.
  • the flow channel adjusting device 14 may be configured as a regulating pipeline and a pipeline switch matched with the enrichment pipeline 11 , wherein the regulating pipelines are respectively provided in the enrichment pipeline Road 11, the pipeline switch is arranged on each regulating pipeline and the enrichment pipeline 11 between the regulating pipelines.
  • the enrichment pipeline is switched between a concentration circulation mode and a dilution mode to adjust the separation efficiency of the first separation module.
  • FIG. 2 shown is a simplified schematic diagram of an enrichment line and a first separation module that can be used to perform the fluid processing method of the present application, in one embodiment.
  • the first separation module is TFFM.
  • the enrichment pipeline 11 can be set as a replaceable consumable part, and when the filtration efficiency drops to a certain degree, the enrichment pipeline 11 can be replaced by In other embodiments, as shown in FIG.
  • the flow direction of the fluid in the enrichment pipeline 11 is adjusted by the flow channel adjustment device 14 to realize the enrichment pipeline Sustainable use of Road 11.
  • the fluid flow direction includes the flow direction and flow channel of the fluid in the enrichment pipeline 11 .
  • the flow channel adjusting device 14 is provided in the first section, in an actual scenario, the flow channel adjusting device 14 may also be provided in the second section, or in the One section and the second section are provided with the flow channel adjusting device 14 at the same time, which is not limited in this application.
  • FIGS. 6 a to 6 c in conjunction with, by controlling the pipeline switch in the flow channel adjusting device 14 , the fluid circulation direction and the flow channel in the enrichment pipeline 11 can be changed.
  • the pipeline switch on the regulating pipeline is turned off and the pipeline switch on the enrichment pipeline 11 is turned on, and the fluid in the enrichment pipeline 11 follows the flow channel of the enrichment pipeline 11 .
  • which can be used for cyclic enrichment to collect the target substance in the state shown in FIG.
  • the first inflow can be made
  • the pipeline switch at the port is closed, so that the fluid in the enrichment pipeline 11 is switched to the concentration cycle mode.
  • the step of enriching the target substance obtained by enrichment is optional.
  • the pipeline switch on the regulating pipeline is turned on and the pipeline switch on the enrichment pipeline 11 is closed, and the The pipeline switch of the first inlet is closed, one end of the two regulating pipelines is connected to the enrichment pipeline 11, and the other end can be used as the inlet and outlet of the enrichment pipeline 11 respectively.
  • the two regulating pipelines cooperate with the enrichment pipeline 11.
  • the pipeline 11 forms a new flow channel, and through the inlet and outlet, the fluid obtained by circulating enrichment or concentration cycle treatment in the enrichment pipeline 11 can be led out of the enrichment pipeline 11, and can also be directed to the enrichment pipeline 11.
  • the cleaning liquid is introduced into the channel 11 to adjust the enrichment pipeline 11 to the cleaning mode, the cleaning solution can enter the enrichment pipeline 11 and the first separation module 12 based on the inlet, and flow to the outlet to clean the The wall of the enrichment pipeline 11 and the first separation module 12, after the cleaning is completed, the target substances trapped in the enrichment pipeline 11 and the first separation module 12 are removed, and can continue to be used for cyclic enrichment of the target substances in the fluid , correspondingly, the flow channel adjusting device 14 can be set to the state shown in FIG. 6a to repeat the fluid treatment.
  • the cleaning solution is a solution that does not contain a target substance, and is intended to remove the target substance in the enrichment pipeline 11 and the first separation module 12 .
  • the cleaning solution may contain surfactants or disinfectants; in medical applications, the cleaning solution is, for example, a physiological buffer that can participate in human blood circulation, such as physiological saline, phosphoric acid Phosphate Buffered Saline (PBS for short), etc.
  • the flow channel adjustment device 14 is a four-way valve.
  • the four-way valve can also be configured as a four-way rotary valve.
  • FIGS. 7a-7b are simplified schematic diagrams of the enrichment pipeline 11 and the flow channel adjusting device 14 in different circulation modes in another embodiment.
  • the enrichment pipeline 11 is provided with a four-way valve, and the fluid flow direction in the enrichment pipeline 11 can be controlled by changing the communication state of different pipelines in the four-way valve.
  • the adjustment process performed by the four-way valve is similar to that in the embodiment shown in FIGS. 6 a to 6 c , and details are not repeated here.
  • the four-way valve can also be rotated to realize adjustment or switching of different working modes in the enrichment pipeline 11 .
  • the four-way valve can determine its structural parameters based on the pipeline parameters of the enrichment pipeline 11 and the position set in the enrichment pipeline 11.
  • the four-way valve can be set as the illustrated embodiment
  • the corners of the intermediate enrichment pipeline 11 can also be set in a straight pipeline, and the corresponding internal structure of the four-way valve is changed accordingly; in some implementations, the four-way valve can be obtained by 3D printing.
  • the cleaning solution inlet in the flow channel adjustment device 14 is opened, and the physiological saline or PBS is inhaled, and enters the circulation.
  • the concentrate is diluted, then the cleaning fluid inlet is closed and the concentration cycle is repeated.
  • most of the small molecule components remaining in the target substance concentrate can be removed.
  • the red blood cells in the blood of blood donors are directly enriched in the circulation through the enrichment cycle, and most of the protein and small molecular components are removed through the above-mentioned multiple concentration and dilution processes to reduce the impact of this part of the loss on the blood donor.
  • the influence of allergic and pathogenic factors in the blood of blood donors on the patient can be effectively reduced, and the cleaned red blood cells can be directly input into the patient's body through the flow channel adjustment device 14 to avoid contact with the outside world.
  • the enrichment pipeline further includes at least one collecting device, which is arranged in the first section or/and the second section, for adjusting the total volume of the enrichment pipeline, collecting air bubbles and Collect more of the target substance.
  • FIG. 8 shows a simplified schematic diagram of the enrichment pipeline 11 in an embodiment of the fluid processing method of the present application.
  • the enrichment pipeline 11 also enriches the target substance in the circulating enrichment mode while circulating the fluid. Therefore, the inner cavity of the enrichment pipeline 11 can be At the same time, it serves as the accommodating space for the target substance; in some examples, the collection device 15 is optionally provided in the enrichment pipeline 11 to expand the internal volume of the enrichment pipeline 11 for collecting the target substance,
  • the collection device 15 can be a container or storage space for expanding the volume of the enrichment pipeline 11, such as the collection cylinder shown in FIG. This application is not limited.
  • the position of the collection device 15 provided in the enrichment pipeline 11 is related to the position of the first separation module 12 ; for example, in the embodiment shown in FIG. 8 , the collection device 15 is provided in the first separation module 12 Upstream, in the concentration cycle mode, the fluid in the collection device 15 has a tendency to flow in accordance with the direction of the cycle based on the action of gravity when the enrichment pipeline 11 is placed naturally. Generally, in the concentration cycle mode, the intake air is discharged.
  • the port is in an open state, so that the design can avoid or reduce the generation of air bubbles in the circulation; in another embodiment, the position of the collecting device 15 can be determined based on the position of the outlet of the regulating pipe in the pipe adjusting device, for example, the The collection device 15 is arranged above the outlet of the adjustment pipe, so that when the enrichment pipe 11 is placed naturally, the fluid in the collection device 15 has a tendency to flow to the outlet to be emptied naturally.
  • the collection device 15 may also be used to provide the exhaust air inlet.
  • the exhaust gas inlet is provided at the upper part of the collecting device 15 to communicate the space in the collecting device 15 that is not filled with fluid and the outside atmosphere or the space of the gas storage device.
  • the collecting device 15 can also be used to set the inlet and outlet of the regulating pipeline in the pipeline regulating device; here, the flow channel regulating device can be integrated into the collecting device 15 to form a module.
  • the enrichment pipeline may further include a control device, a storage device, a pressure detection device, a temperature detection device, a temperature control device, a bubble detection and removal device, an alarm device, and a concentration detection device at least one of them.
  • control device can be used to control the first drive device to determine the fluid flow rate in the enrichment pipeline, or to control the switch of the first inlet pipeline to determine the flow rate of the fluid in the enrichment pipeline.
  • the control device controls the temperature control device to perform heating or cooling based on the temperature information detected by the temperature monitoring device.
  • the temperature control device may also be a constant temperature device.
  • the storage device can be used to store the fluid in the enrichment pipeline on the second side of the first separation module after separation and processing, and in some examples, the storage device can also be connected to one of the processing modules.
  • the air bubble detection device can be used to obtain a control signal. For example, during the concentration cycle, the air bubble detection can reflect that the collection device is close to emptying, and can dilute or discharge the concentrated target substance. Alternatively, the air bubble detection device can be used to obtain an early warning signal, indicating that the equipment is not in a normal working state, including but not limited to, the liquid in the circulation is excessively emptied, the collection device is not properly placed, the liquid to be treated contains air bubbles or leaks. Wait.
  • the control device determines the internal state of the enrichment pipeline based on the detection parameter to control the control signal to the alarm device.
  • the control signals are multiple and correspond to different alarm types.
  • the control signal a is triggered to make the alarm device issue an alarm corresponding to the abnormal pressure;
  • the control device judges based on the detection value of the concentration detection device
  • the concentration inside the enrichment pipeline reaches the preset value so that the cyclic enrichment cannot continue or the concentration is abnormal
  • the control signal b is triggered, so that the alarm device sends out an alarm corresponding to the abnormal concentration.
  • the enrichment pipeline further includes a flow rate detection device for detecting the dynamic state inside the enrichment pipeline, so as to form adjustment information for the internal working state of the enrichment pipeline.
  • the flow velocity detection device is, for example, used to detect at least one of the flow velocity of the inlet port, the flow velocity of the outlet port, and the flow velocity of the fluid at the separation module, so as to determine the dynamic state inside the pipeline.
  • it is determined by the flow rate detection device whether the fluid inside the pipeline is in a weak dynamic state for example, the flow rate in the fluid is lower than a preset range or the flow rate of the fluid filtered at the discharge port is significantly decreased etc.
  • the working state of the first separation module can be judged, for example, whether the first separation component has molecular inhibition, blockage, etc., and the flow rate detection device can thus form adjustment information for the internal working state of the pipeline.
  • the adjustment information is, for example, the working mode switching information for adjusting the enrichment pipeline to the concentration circulation mode or the cleaning mode, or the adjustment information for the flow rates of different regions in the enrichment pipeline.
  • the adjustment information may be formed by the control device after receiving the flow velocity signal, and the control device controls the flow channel adjustment device, the drive device, etc. in the pipeline based on the adjustment information to adjust the internal working state of the pipeline.
  • the adjustment information formed by the control device is formed based on at least one of the flow rate detection device, the pressure detection device, and the concentration detection device, for example, the control device receives the management flow rate information, pressure At least one of the information and the fluid concentration information is then integrated to form adjustment information to control the flow channel adjustment device, the drive device, and the like in the pipeline.
  • the fluid processing method further comprises: communicating the fluid drawn from the first discharge port corresponding to the preceding enrichment pipeline to the subsequent enrichment The first inlet port corresponding to the pipeline, so that the fluid circulates in N cascaded enrichment pipelines to enrich the target substance, wherein N is a positive integer of 2 or more (N ⁇ 2).
  • FIG. 9 a simplified schematic diagram of two enrichment circuits in a phase cascade is shown in one embodiment.
  • the preceding enrichment pipeline and the succeeding enrichment pipeline are used to describe any two adjacent enrichment pipelines among the cascaded N enrichment pipelines. That is, the connection order, which is differentiated based on the flow direction of the fluid in the enrichment line, i.e., the fluid always flows from the previous enrichment line after being processed into the later enrichment line for reprocessing, therefore, the fluid Always go from the first outlet of the preceding enrichment line to the first inlet of the succeeding enrichment line.
  • the fluid follows the connection sequence of the enrichment pipelines for N cycles of processing.
  • the first inlet in the cycle enrichment mode It is equal to the fluid flow rate or flow rate at the first discharge outlet, therefore, continuous enrichment of the target substance can be performed in each of the enrichment pipelines, and the N cascaded enrichment pipelines are in The cyclic enrichment mode is in dynamic equilibrium, so the enrichment process is sustainable.
  • the fluids are sequentially retained in the cascaded enrichment pipelines to retain the target substances. Therefore, the fluid components introduced at the first inlet of each enrichment pipeline are different, and the corresponding , the target substances enriched in different enrichment pipelines can be different.
  • the different components of the fluid include: different types of substances in the fluid or/and different concentrations or total amounts of at least one substance in the fluid.
  • the present application provides an example of processing fluids by employing N cascaded enrichment lines, which can be used to treat molecules of different particle sizes or molecular weights, components of different chemical properties, or molecules of different charge properties in the fluid. Enrichment is carried out separately. By setting the corresponding first separation module in the enrichment pipeline, based on the selective permeability of the different first separation modules to the components in the fluid, the difference in fine-grained classification can be realized. enrichment of components.
  • the fluid obtained by circulating and enriching in each enrichment pipeline of the N cascaded enrichment pipelines may be led out of the enrichment pipeline based on the outlet of the adjustment pipeline of the flow channel adjustment device, or based on The processing module leads out the enrichment pipeline, so that the fine-grained target substance can be directionally extracted or processed, thereby realizing the change of the concentration of the target substance under the fine-grained classification in the fluid.
  • the molecular weight of each component in the fluid ranges from 200 to 2000 Dalton
  • the corresponding target substance to be extracted or processed has a molecular weight of 1000 to 1100 Dalton.
  • the front enrichment pipeline 11 correspond to the components above 1100 Daltons in the intercepted fluid of the first separation module 12, and make the first separation module 12 intercept 1000 Daltons in the fluid leading out of the enrichment pipeline in the latter enrichment pipeline 11
  • the following components can be enriched in the post-enrichment pipeline 11 with a target substance of 1000-1100 Dalton.
  • the number of the N cascaded enrichment pipelines is any positive integer greater than 2 (N ⁇ 2).
  • the components are enriched, extracted or processed separately; here, the classification segment may be a classification segment obtained by dividing based on at least one of the chemical properties, molecular weight or molecular particle size, and charge properties of the components, it should be understood that,
  • the classification section has a variety of classification standards, and it is sufficient to have a corresponding first separation component so that the material in the classification section can be enriched.
  • the first separation component as a separation membrane as an example, different types of separation membranes have With different permeabilities, by setting N groups of separation membranes, the fluid components can be classified or intercepted N times.
  • compliance with the connection order can enrich macromolecular components based on molecular weight in the first enrichment circuit and in the second enrichment circuit
  • the non-permeable components corresponding to the first separation module of the enrichment circuit can be enriched based on the chemical properties of the fluid, and the charged components can be enriched in the third enrichment circuit based on the charge properties of the fluid components ion.
  • the N cascaded enrichment pipelines can be used, for example, to enrich antibiotics, amino acids, enzymes, and other proteins in the fluid.
  • the types of components in the fluid are limited.
  • the connection order so that the first separation module corresponding to each enrichment pipeline only intercepts one component in the fluid it can also be understood that because only one fluid component is contained in one of the classification sections, the N cascaded enrichment pipelines can enrich any component in the fluid, and can also remove any component in the fluid. Or change the concentration of any component, or perform reprocessing such as filtration, adsorption, heating, catalysis, enrichment, concentration, chemical treatment, optical treatment, electrical treatment, etc. on any component.
  • the molecular particle size, molecular weight, or component particle size of the N cascaded enrichment pipelines corresponding to the enriched target substance decreases step by step in accordance with the connection order.
  • the components in the fluid are classified according to molecular particle size or molecular weight, and the selective permeability of the first separation module corresponding to the N cascaded enrichment pipelines to the fluid components can be based on the component particle size diameter or molecular weight design, for example, the average pore size of the separation membranes in the first separation modules of the N groups corresponding to the N cascaded enrichment pipelines can be gradually reduced or the molecular weight cut-off can be gradually reduced, then the order of connection is followed.
  • the molecular size or molecular weight corresponding to the target substance obtained by circulating enrichment in the header pipe gradually decreases.
  • the enrichment of any component in the fluid can be achieved by controlling the difference in particle size or molecular weight cut-off between the separation membranes corresponding to the previous enrichment pipeline and the subsequent enrichment pipeline.
  • the smaller the difference in particle size or molecular weight cut-off between the separation membranes the more conducive to reducing the enrichment of interfering molecules, but there is a possibility of reducing the enrichment efficiency of target substances.
  • Factors such as fluid components, target substances, interfering molecules, and enrichment efficiency can also be integrated when the first separation module corresponding to the connected enrichment pipeline is connected.
  • the fluid processing method is exemplified by a practical application scenario.
  • the N cascaded enrichment tubes The different components in the plasma can be divided into finer particle sizes based on particle size or molecular weight, and the components of different particle size categories or molecular weight categories can be enriched in different enrichment pipelines.
  • Targeted collection of fractions, the corresponding disease types can be expanded in clinical use, for example, small molecule pathogenic factors or multiple pathogenic factors can be enriched and processed; at the same time, the N cascades of enrichment
  • the collecting pipeline is sustainable and does not generate waste liquid during the treatment process.
  • the problem of continuous loss of beneficial components during separation can be effectively solved, and the problem of continuous loss of beneficial components in the separation can be effectively reduced.
  • Continued loss of beneficial components, while the duration of the cycle can be determined based on predetermined therapeutic goals such as reducing the concentration of a particular component such as a pathogenic factor below a preset value, i.e., the fluid treatment method can control the impact on pathogenic factors.
  • the removal effect of the factor can be used to determine the processing time, which solves the problem of difficult to control the removal rate.
  • FIG. 10 shows a schematic flowchart of the fluid processing method of the present application in an embodiment.
  • the fluid treatment method further comprises the following steps:
  • step S20 the fluid drawn from the first discharge port corresponding to an enrichment pipeline is introduced into a separation pipeline based on at least one second separation module; wherein, the separation pipeline has an inlet and an outlet; so
  • the second separation module has a first side and a second side separated by the second separation component, and opposite ends of the first side of the second separation module are respectively connected to at least one second inlet port and at least one second outlet port, The opposite ends of the second side of the second separation module are respectively connected to the inlet and the outlet of the separation pipeline;
  • step S21 the fluid is driven to flow from the inlet to the outlet at a preset flow rate in the separation pipeline based on at least one second driving device, so as to control the dynamic balance of the total amount of fluid in the separation pipeline.
  • the first aspect of the present application also provides an embodiment of cascading the enrichment pipeline and the separation pipeline.
  • the embodiment of cascading the enrichment pipeline and the separation pipeline provided in the first aspect of the present application includes the following situation: the fluid is led out from the first discharge port of one enrichment pipeline to the other The second inlet corresponding to the separation pipeline; or, the fluid is processed in the enrichment pipelines with more than N phases cascaded, and the first outlet of the last enrichment pipeline is connected to the connection sequence according to the connection sequence.
  • N is a positive integer of 2 or more (N ⁇ 2).
  • FIG. 11 shows a simplified schematic diagram of an enrichment line and a separation line in a phase cascade in one embodiment.
  • the fluid in the separation pipeline 21 is the separated fluid passing through the second separation module 22 , and the inlet and the outlet of the separation pipeline 21 are connected to opposite ends of the second side of the second separation module 22 , namely, A reversible cyclic separation can be formed.
  • the reversible cyclic separation that is, the separation fluid in the separation pipeline 21 can return to the first side of the second separation module 22 according to the circulation direction.
  • the target substance can be quantitatively collected based on the separation pipeline 21, for example, the active ingredients of traditional Chinese medicine are extracted from the medicinal liquid, and the collected target substance circulates in the separation pipeline 21; At the same time, the target substance exceeding the predetermined collection or processing amount may be separated back to the first side of the second separation module 22 based on the reversible cycle.
  • the fluid treatment method can be used to realize the treatment of specific components in the fluid, for example, the fluid including components a, b, c is introduced into the enrichment pipe
  • the enrichment component a is circulated in the enrichment pipeline 11, and the fluid components b and c drawn from the first discharge port are connected to the second separation module 22 corresponding to the separation pipeline 21, and the component b is
  • the second separation component of the second separation module 22 is intercepted on the first side of the second separation module 22, the fluid in the separation pipeline 21 is the fluid containing only component c, and the processing module 24 can By separating the fluid in the pipeline 21 for treatment, only the specific component c in the fluid can be treated.
  • the fluid drawn from the first discharge port can be intercepted at the second separation module 22 to retain some components, so as to separate the circulating flow in the separation pipeline 21
  • the fluid only contains certain components; the total amount of fluid in the separation pipeline 21 is dynamically balanced, so that the cyclic separation can be continuously performed.
  • the separation pipeline and the second separation module may form different circulation paths, such as rectangles in the example shown in FIG. 11 , of course, in other ways, the circulation paths may include multiple polylines such as “convex” Fonts, or arcs such as arcs.
  • the separation pipeline circulates and transmits fluid. Based on the needs of equipment in different scenarios, the diameter, material, and path of the separation pipeline can be used. Adjust accordingly.
  • the pipeline material of the separation pipeline can be set to a special material corresponding to the fluid, for example, it can be set to a special pipeline for blood, a special pipeline for a peristaltic pump, a special pipeline for corrosive liquids, and a high biocompatibility Pipelines, etc.; taking the application of the fluid processing method in medical scenarios as an example, the separation pipeline is, for example, a blood delivery pipeline or a liquid medicine delivery pipeline, and the pipeline materials include but are not limited to soft polyvinyl chloride plastic, high Performance Polyolefin thermoplastic elastomer (TPE), nano-biomedical materials, resin materials.
  • TPE High Performance Polyolefin thermoplastic elastomer
  • the second separation module 22 has a first side and a second side separated by a second separation component, and opposite ends of the first side of the second separation module are respectively connected to at least one second inlet and at least one second outlet.
  • the second separation module can be used to separate specific components of the fluid drawn from the first discharge port corresponding to the enrichment pipeline 11 .
  • the separated specific component is the separation fluid that reaches the second side of the second separation module, and the separated fluid may be a fluid component that needs to be retained or a component that needs to be removed from the fluid.
  • the second separation module is a relatively closed cavity structure, that is, two ends of the first side of the second separation module are respectively connected to the second inlet and the second outlet.
  • a closed cavity is formed on the first side of the second separation module; in other embodiments, when the second separation module is first
  • the inlet and outlet of the separation pipeline communicated on the two sides are closed, and the second side of the second separation module also forms a closed cavity.
  • the fluid is connected from the first discharge port to the corresponding second inlet port of the second separation module and enters the separation pipeline, in this process, the contact with the external space can be avoided, in some special cases, such as In blood delivery in medical scenarios, the relatively closed structure can form a sterile environment or reduce infections such as bacteria, microorganisms, and viruses.
  • the second separation module has a second separation component, the second separation component can contact the fluid and selectively permeate specific material components in the fluid; the second separation component separates the second separation module and allows the passage of The fluid of the second separation assembly communicates to the second side of the second separation module.
  • the fluid drawn from the first discharge port of the enrichment line 11 can flow from the separation line inlet connected to the second side of the second separation module to the separation line outlet, thereby forming cycle.
  • the first side of the second separation module and the second side of the second separation module are used to distinguish the positions of the separated fluid passing through the second separation component and the intercepted fluid, and the first side and the second side
  • the positional relationship of the sides is determined by the cavity structure of the second separation module and the structure of the second separation assembly.
  • the second separation component is a planar structure and is laterally arranged in the second separation module
  • the first side and the second side are the upper side and the lower side respectively
  • the second separation component is The planar structure is vertically arranged in the second separation module, and the first side and the second side are respectively the left side and the right side.
  • the second separation component is a structure or material having selective permeability to some components in the fluid drawn from the first discharge port of the enrichment pipeline, such as a filter, a filter membrane, and a porous metal material.
  • the second separation component is a separation membrane
  • the specific type of the separation membrane can be determined based on the difference in physical and chemical properties between each component of the fluid and the target substance, for example, including: a reverse osmosis membrane, Nanofiltration membrane, ultrafiltration membrane, microfiltration membrane, electrodialysis membrane, pervaporation membrane, liquid membrane, gas separation membrane, electrode membrane, etc.
  • the separation membrane is a high-purity polymer, chemically inactive, and has good hemocompatibility and histocompatibility.
  • the second separation component may be configured as a porous membrane, a reverse osmosis membrane, or a gas separation membrane.
  • the average pore size or molecular weight cut-off (MWCO) of the porous membrane or reverse osmosis membrane is related to the target substance, wherein the porous membrane includes a microfiltration membrane, an ultrafiltration membrane, or a nanofiltration membrane.
  • a membrane that is suitable for retaining the target substance or filtering the target substance is selected.
  • the corresponding separation membrane can be a nanofiltration membrane or a reverse osmosis membrane to achieve the retention of the target substance.
  • the separation membrane achieves the retention, filtration or exchange of target species through steric hindrance effect, Donan effect or electrostatic effect, adsorption, diffusion, charge repulsion effect, pore effect, or dissolution.
  • the substance components selectively permeated by the separation membrane are related to the type of the separation membrane and the composition of the target substance.
  • a corresponding separation membrane can be set based on the predetermined target substance composition to process the fluid.
  • the separation membrane is, for example, a porous membrane with an average pore size smaller than the molecular diameter of the pathogenic factor, so that the macromolecule is pathogenic
  • the factor is retained on the first side of the second separation module; for another example, when the target substance is a charged ion in a neutral electrolyte liquid, based on the characteristics of the nanofiltration membrane that usually selectively transfers ions according to the charge repulsion effect and the pore effect, so
  • the second separation component can be set as a nanofiltration membrane to realize filtration; for another example, when the fluid is a gas mixture, the corresponding second separation component can be set as a gas separation membrane to separate a specific gas in the fluid through gas separation membrane to achieve the separation of different gas components.
  • the treatment of the target substance may be determined as retention or filtration based on the composition of the fluid and the target substance, thereby determining the average pore size of the separation membrane suitable for retention or filtration of the target substance based on the molecular size of the target substance or molecular weight cut-off to set the separation membrane used in the actual scene; in other examples, when determining the specific type of the separation membrane, reference may also be made to the Daunan effect, adsorption, dissolution, etc. A membrane that can achieve a preset separation effect is set in the separation module.
  • the pore size and type of the corresponding separation membrane can be determined on the basis that the second separation component can intercept more than 90% of the target substance, or the second separation component can be used for the target based on higher separation effect requirements.
  • the rejection rate of substances is set to be above 95% or even above 99% to determine the corresponding pore size and type of separation membrane.
  • the separation membrane may include, for example, a symmetric membrane, an asymmetric membrane, a composite membrane, a multi-layer composite membrane, and the like.
  • the second separation component can also be configured as separation membranes with different geometric shapes to adapt to different fluids or achieve different filtering effects.
  • the second separation module includes one or more of flat membranes, tubular membranes, rolled membranes, spiral membranes, and hollow fiber membranes.
  • the positional relationship between the first side and the second side of the corresponding second separation module may be different based on the different geometrical separation membranes set by the second separation module; for example, when the second separation module is Planar membrane, the first side of the second separation module and the second side of the second separation module are opposite sides of the planar structure barrier; for another example, when the second separation module is a hollow fiber membrane, the first The first side of the two separation modules is the inner side of each fiber membrane tube wall, and the second side of the second separation module is the outer side of each fiber membrane tube wall.
  • the flow angle of the fluid relative to the separation membrane can be set to different angles, such as 0° to 90°.
  • the flow angle of the fluid relative to the separation membrane is 0°, that is, the fluid flows parallel to the surface of the separation membrane. , such as common tangential flow filtration; when the flow angle of the fluid relative to the separation membrane is 90°, that is, the fluid flows in a direction perpendicular to the membrane surface, such as conventional dead-end filtration (also called vertical filtration).
  • the flow channels in the second separation module can be arranged in a folded and reciprocating form, for example, by folding a flat membrane to increase the contact surface area between the fluid and the flat membrane, correspondingly, the flow channels are arranged It is folded and reciprocated to match the structure of the separation membrane, so as to ensure that the separation membrane separates the second separation module to form a first side and a second side.
  • the second separation module is a tangential flow filtration module.
  • step S21 the fluid is driven to flow from the inlet to the outlet at a preset flow rate in the separation pipeline based on at least one second driving device, so as to control the dynamic balance of the total amount of fluid in the separation pipeline.
  • the second driving device 23 includes but is not limited to a peristaltic pump, a pressure pump, an electric field, a heater, a hydraulic pump or a vacuum pump, and is used to provide power to the fluid in the enrichment pipeline to make the fluid
  • the flow follows the preset flow direction, that is, flows from the inlet to the outlet of the separation pipeline 21 to form a dynamic circulation.
  • the total amount of fluid in the separation pipeline 21 is dynamically balanced; in the circulating separation mode, the second feed
  • the flow port keeps the fluid introduced into the second separation module 22, and the specific components in the fluid that pass through the second separation assembly flow into the separation line 21 connected to the second side of the second separation module 22, and the specific components from the separation line
  • the inlet of 21 flows to the second side of the second separation module 22 connected to the outlet of the separation pipeline 21 to form a circulation, and at the same time, the second discharge port on the first side of the second separation module 22 leads the fluid out of the second separation module 22;
  • the total amount of fluid in the separation pipeline 21 is balanced, by controlling the second inlet port to introduce fluid to the first side of the second separation module 22 and the second outlet port to the first side.
  • the flow rates of the fluids drawn from the first side of the two separation modules 22 are equalized.
  • the second driving device 23 can drive the fluid in the pipeline at different positions in the separation pipeline 21 , and the flow rate of the second driving device 23 may be caused by factors such as pipeline resistance, temperature, and pressure due to the flow direction of the fluid. The speed changes.
  • a plurality of second driving devices 23 may be provided in the separation pipeline 21 to control the flow velocity at different positions in the separation pipeline 21 to be preset values.
  • the separation line can also be connected to a processing module 24 to reprocess the separation fluid in the separation line or the fluid drawn from the second outlet; here,
  • the composition of the separation fluid can be controlled based on the second separation module, ie the fluid is thus connected to the second separation module after the target substance has been trapped in the enrichment pipeline via the first separation module, through the second separation module
  • the module allows a specific component to enter the separation pipeline, and through the separation pipeline, it can be used to change the concentration of the specific component in the fluid after the target substance is trapped by the first separation module, or to allow the processing module to adjust the concentration of the specific component.
  • Certain components are reprocessed. Wherein, the reprocessing includes but is not limited to at least one of filtration, adsorption, heating, catalysis, enrichment, concentration, chemical treatment, optical treatment, and electrical treatment.
  • the processing module 24 may be disposed in the separation pipeline to adjust the flow direction or flow path of the separation fluid, that is, the processing module 24 also For the flow channel adjustment device.
  • the flow channel adjustment device can be configured as an adjustment pipeline and a pipeline switch matched with the separation pipeline, wherein the adjustment pipeline is respectively provided in the separate pipeline, and the pipeline switch is provided in each adjustment pipeline. Separation lines on pipes and between conditioning pipes.
  • the fluid circulation direction and the flow channel in the separation pipeline can be changed.
  • the pipeline switch on the regulating pipeline is turned off and the pipeline switch on the separation pipeline is turned on, and the fluid in the separation pipeline flows in accordance with the flow channel of the separation pipeline, which can be used for cyclic separation;
  • the separation pipeline needs to be cleaned, in the cleaning mode, one end of the two adjustment pipelines is connected to the separation pipeline, and the other end can be used as the inlet and outlet of the separation pipeline respectively.
  • the two adjustment pipelines cooperate with each other.
  • the separation line forms a new flow channel, that is, the separation fluid circulated and separated in the separation line can be led out of the separation line from the outlet, and cleaning liquid can also be introduced into the separation line to separate the separation line.
  • the circuit is adjusted to the cleaning mode, the cleaning liquid can enter the separation pipeline and the second separation module based on the inlet, and flow to the outlet to clean the wall of the separation pipeline and the second separation module.
  • the separation tube The target substance in the path and the second separation module is removed.
  • the flow channel adjustment device corresponding to the separation pipeline is a four-way valve.
  • the four-way valve can also be rotated to achieve adjustment or switching of different working modes in the separation pipeline.
  • the four-way valve can determine its structural parameters based on the pipeline parameters of the separation pipeline and the position set in the separation pipeline.
  • the four-way valve can be set at the corner of the separation pipeline, or can be In a straight pipeline, the internal structure of the corresponding four-way valve can be changed accordingly; in some implementations, the four-way valve can be obtained by 3D printing.
  • the processing module 24 is a collection device. It should be understood that in the fluid processing method of the present application, the separation pipeline 21 collects a certain volume of separation fluid in a circulating separation mode while circulating fluid.
  • the target substance therefore, the inner cavity of the separation pipeline 21 can also serve as the accommodating space for the target substance, and the collection device can be a container or storage space for expanding the volume of the separation pipeline 21 .
  • the separation pipeline is further provided with at least one of a control device, a storage device, a pressure detection device, a temperature detection device, a temperature control device, a bubble detection and removal device, an alarm device, and a concentration detection device kind.
  • control device is arranged in the enrichment pipeline or the control device is arranged in the separation pipeline, which does not limit the position of the control device.
  • the device can be electrically connected to each driving device, detection device, or sensor in the enrichment pipeline or separation pipeline, so the control device can of course be located outside the pipeline; the control device is used to obtain the enrichment pipeline. Or the working state information in the separation pipeline, and realize the control of the working state in the enrichment pipeline or the separation pipeline.
  • the second inlet port corresponding to the separation pipeline is communicated with the first outlet port of the enrichment pipeline.
  • the control device is a control device.
  • the central system of the cascaded enrichment pipeline and the separation pipeline, here, the control device connects the enrichment pipeline and the separation pipeline at the same time; in other examples, the enrichment pipeline
  • the circuit and separation line can also be connected to different control devices.
  • step S10, step S11, and step S12 in the fluid processing method is not necessarily limited.
  • step S12 may be executed first, and then executed Step S10; here, the step S10, step S11, and step S12 can be regarded as necessary conditions for the execution of the fluid processing method of the present application, and the fluid processing method of the present application can be implemented if each condition is satisfied.
  • the order of occurrence is not limited, and the implementation manner from step S10 to step S11 to step S12 is only a description manner selected for easy understanding.
  • the fluid treatment method is used in the treatment of diseases, for example, the enrichment and selective removal of target molecules can be achieved by an extracorporeal circulation removal system that can perform the fluid treatment method of the present application
  • target molecules are often pathogenic factors or results in the development of diseases, or are critical to the development of diseases or maintenance of health, and the removal of target molecules is beneficial to the treatment of diseases or the reduction of complications
  • the said Diseases include but are not limited to familial hypercholesterolemia, hyperlipoproteinemia, systemic lupus erythematosus, autoimmune disease, myasthenia gravis, rapidly progressive glomerulonephritis, fatty liver, cirrhosis, acute liver failure, hyperthyroidism
  • the types of diseases that the fluid handling method is adapted to treat are not limited to the foregoing examples, only if The fluid
  • the treatment includes preventative (ie, prophylactic), blocking, curative, or palliative treatments that result in the desired physiological effect.
  • the term “treating” is used herein to mean partially or fully ameliorating, delaying the onset, inhibiting progression, lessening the severity, and/or reducing the appearance of one or more symptoms of a particular disease, abnormality and/or medical condition the purpose of probability.
  • the target substance in blood or interstitial fluid can be subjected to sustainable and Highly selective enrichment and clearance, thereby altering the concentration of pathogenic factors in patients.
  • a corresponding separation module is selected or designed to determine pathogenic factors in blood or tissue fluid for a specific disease type, that is, to enrich or remove specific pathogenic factors in the pipeline.
  • the blood or interstitial fluid drawn from the patient can also be pretreated by the processing module, and then the target substances in the plasma or interstitial fluid obtained by the pretreatment can be enriched or eliminated, and can be controlled based on a preset clearance target. processing time.
  • the target substance enriched by the enrichment circuit circulation or the separation fluid separated by circulation in the separation circuit can also be connected to a processing module for reprocessing, which can treat the target Substances or separated fluids are decomposed, catalyzed, heated, concentrated, etc.
  • the target substance in the fluid is intercepted through the enrichment pipeline and the first separation module, and the target substance is cyclically enriched in the enrichment pipeline, where the cyclic enrichment is carried out.
  • the fluid in the enrichment pipeline flows at a preset flow rate according to the first driving device, so as to ensure the dynamic balance of the total amount of fluid in the enrichment pipeline, so the fluid treatment method of the present application has the advantages of It is sustainable, and can realize the collection or treatment of some components in the fluid, that is, the target substance, and the fluid drawn from the first outlet of the enrichment pipeline can be connected to the processing module or storage space; here, the The fluid treatment method is sustainable, so that a controllable separation effect can be achieved.
  • the total amount of fluid in the enrichment pipeline is balanced during the cyclic enrichment process, which can avoid the separation effect from being greatly reduced with the separation.
  • the target in the fluid Substances can be circulated through the first separation module to be retained, avoiding continuous loss of beneficial components during component separation or exchange of the fluid.
  • the fluid treatment method can realize the treatment of target components in the fluid under fine-grained classification based on cascaded enrichment pipelines or phase cascaded enrichment pipelines and separation pipelines,
  • the collection or processing of any component in the fluid can be realized, which can eliminate or reduce application limitations in different fields.
  • different components in human body fluids including blood
  • the present application also provides a fluid processing method in a second aspect, comprising the steps of: introducing fluid into a separation pipeline based on at least one second separation module; wherein the separation pipeline has an inlet and an outlet; the second The separation module has a first side and a second side separated by a second separation component, and opposite ends of the first side of the second separation module are respectively connected to at least one second inlet and at least one second outlet, and the second separation The opposite ends of the second side of the module are respectively connected to the inlet and the outlet of the separation pipe; based on at least one second driving device, the fluid in the separation pipe is driven to flow from the inlet to the outlet at a preset flow rate, so as to control the separation pipe The total amount of fluid in the circuit is dynamically balanced.
  • the fluid contains the target substance, and in certain embodiments, the fluid includes but is not limited to blood, plasma, serum, body fluid, tissue fluid, washing fluid, dialysate, recombinant protein solution, cell culture fluid, microbial culture fluid, pharmaceutical and a mixture of one or more of medical water, medicinal liquid, fluid food, animal and plant extracts, natural water, industrial wastewater, reclaimed water, light oil, methane, and liquefied gas; in some examples, the The fluid can also be a material component obtained after processing, eg, filtration, of a fluid such as blood, plasma, etc.; in other examples, the fluid can also be a gas mixture, such as a gas mixture including methane.
  • the fluid treatment method of the present application can be applied to the treatment of different types of fluids.
  • the fluid has different material components, such as the fluid has a difference in selective permeation when it is transported in a separation membrane.
  • the components and certain fluidity are sufficient to enable the separation process, such as the above-mentioned liquid mixture or gas mixture, and the fluid may be other solid-liquid mixed phase fluid or colloid, which is not limited in this application.
  • FIG. 13 shows a schematic flowchart of an embodiment of the fluid processing method according to the second aspect of the present application.
  • step S30 the fluid is introduced into a separation pipeline based on at least one second separation module, wherein the separation pipeline has an inlet and an outlet; the second separation module has a first side formed by the separation of the second separation component and On the second side, opposite ends of the first side of the second separation module are respectively connected to at least one second inlet and at least one second outlet, and opposite ends of the second side of the second separation module are respectively connected to the separation pipe Road entrances and exits.
  • step S31 the fluid is driven to flow from the inlet to the outlet at a preset flow rate in the separation pipeline based on at least one second driving device, so as to control the dynamic balance of the total amount of fluid in the separation pipeline.
  • the second separation component is a porous membrane, a reverse osmosis membrane or a gas separation membrane.
  • the average pore size or molecular cut-off of the porous membrane or reverse osmosis membrane is related to the fluid composition, wherein the porous membrane includes microfiltration membranes, ultrafiltration membranes, and nanofiltration membranes.
  • the second separation module includes one or more of sheet membranes, tubular membranes, rolled membranes, spiral membranes, and hollow fiber membranes.
  • the separation pipeline is further provided with a control device, a fluid storage device, a pressure detection device, a temperature detection device, a temperature control device, an oxygen detection device, a bubble detection and removal device, an alarm device, and a concentration detection device at least one of the devices.
  • the optional form of the second separation component is related to the preset processing target of the target substance in the fluid.
  • the fluid in the preceding separation line is communicated to the corresponding second inlet port of the latter separation line, so that the fluid flows through the N cascaded separation lines Circulating flow in the road, wherein, N is a positive integer of 2 or more (N ⁇ 2).
  • FIG. 14 is a simplified schematic diagram of N cascaded separation pipelines in one embodiment.
  • the preceding separation pipeline and the succeeding separation pipeline are used to describe any two adjacent separation pipelines in the cascaded N separation pipelines, and the preceding and succeeding order is the connection order,
  • the connection sequence is differentiated based on the flow direction of the fluid in the separation line, i.e. the fluid always flows from the preceding separation line after being processed into the latter separation line for reprocessing, and therefore the fluid always flows from the preceding separation line.
  • the inlet of the pipeline enters the second inlet connected to the second separation module of the latter separation pipeline, and correspondingly, the second outlet connected to the second separation module of the latter separation pipeline is connected to the preceding separation pipeline. road exit.
  • the fluid follows the connection sequence of the separation pipelines to perform N separation cycles.
  • the second inlet and the second row of The fluid velocity or flow at the orifice is equal, that is, the N cascaded separation pipelines are all in dynamic equilibrium, and therefore, continuous cyclic separation can be performed in each of the separation pipelines.
  • the fluids are sequentially trapped in the first side of the second separation module corresponding to the cascaded separation pipelines. Therefore, the fluid introduced at the second inlet of each separation pipeline is The components are different, correspondingly, the fluid components in different separation pipelines are different.
  • the different components of the fluid include: different types of substances in the fluid or/and different concentrations or total amounts of at least one substance in the fluid.
  • the present application provides an embodiment of processing fluid by adopting N cascaded separation pipelines, which can be used to separate different particle sizes or molecular weights, components of different chemical properties, or molecules of different charge properties in the fluid.
  • N cascaded separation pipelines which can be used to separate different particle sizes or molecular weights, components of different chemical properties, or molecules of different charge properties in the fluid.
  • the separation of different components under fine-grained classification can be realized. Cycle separation.
  • the fluid in the separation pipeline of the present application is reversible in the circulation separation mode, and based on the interception effect of the second separation module, the separation pipeline connected to the second side of the second separation module can be realized.
  • the fluid of the second separation module only contains a specific component, and the fluid on the first side of the second separation module may include the specific component and the intercepted component at the same time. Connection sequence, the fluid component categories in the separation line are gradually reduced.
  • the reversible circulation in the separation goes back to the upstream, for example, in the embodiment shown in Figure 14, when the fluid includes components a, b, c, d, in the separation process, following the connection order, the first separation tube
  • the fluid components in the channel 21 are b, c, and d, wherein the component a is trapped on the first side of the second separation module 22a corresponding to the first separation pipeline 21a; the fluid components in the second separation pipeline 21b
  • component b is retained on the first side of the second separation module 22b corresponding to the second separation line 21b and can flow to the first separation line 21a from there, and at the same time, component b can be based on the
  • the reversible cyclic separation is returned to the first side of the second separation module 22
  • the separation fluid in the separation pipeline may be led out of the separation pipeline based on the adjustment pipeline outlet of the flow channel adjustment device, or led out of the separation pipeline based on the processing module.
  • the pipeline can extract or process the fine-grained target substance directionally, thereby realizing the change of the concentration of the target substance in the fluid under the fine-grained classification. For example, when the molecular weight of each component in the fluid ranges from 200 to 2000 Dalton, taking N as 2 as an example, following the connection sequence, the preceding separation pipeline corresponds to the components above 1100 Dalton in the intercepted fluid of the second separation module.
  • the separation fluid component in the front separation pipeline is 200-1100 Dalton, so that the second separation module corresponding to the rear separation pipeline retains more than 800 Dalton components, and the separation fluid component in the rear separation pipeline is 200 ⁇ 1100 Dalton. 800 Dalton's components.
  • the number of the N cascaded separation pipelines is any positive integer greater than 2.
  • various components in the fluid or components in multiple classification sections can be collected separately. , extraction or processing; here, the classification segment may be a classification segment obtained by dividing based on at least one of the chemical properties of components, molecular weight or molecular particle size, and charge properties, and it should be understood that the classification segment has a variety of The division standard is to have a corresponding second separation component so that the substances in the classification section can be trapped on the first side of the second separation module.
  • the second separation component as a separation membrane as an example, different types of separation membranes have With different permeabilities, by setting N groups of separation membranes, the fluid components can be classified or intercepted N times.
  • the compliance connection order may, based on molecular weight, intercept macromolecular components on the first side of the second separation module corresponding to the first separation line, and at the second The second separation module corresponding to the separation pipeline can intercept the components that do not have selective permeability in the second separation module corresponding to the separation pipeline based on the chemical properties of the fluid, and the third separation pipeline is based on the fluid components
  • the charge properties trap charged ions.
  • the N cascaded separation pipelines can be used, for example, to separate antibiotics, amino acids, enzymes, and other proteins in the fluid.
  • the molecular particle size, molecular weight, or component particle size of the target substance corresponding to the N cascaded separation pipelines decreases step by step according to the connection order.
  • the components in the fluid are classified according to molecular particle size or molecular weight, and the selective permeability of the second separation module corresponding to the N cascaded separation pipelines to the fluid components may be based on the particle size of the components Or molecular weight design, for example, the average pore size of the separation membrane in the second separation module of the N groups corresponding to the N cascaded separation pipelines can be gradually reduced or the molecular weight cut-off can be gradually reduced.
  • the molecular particle size or molecular weight corresponding to the target substance retained on the first side of the corresponding second separation module in the corresponding second separation module gradually decreases.
  • the second separation module corresponding to each separation pipeline can retain part of the components in the fluid on the first side of the second separation module, so the second side of the second separation module can only contain specific components in the fluid.
  • the corresponding separation pipeline can be selected based on the needs, that is, only specific components in the fluid can be processed.
  • the following step is further included: introducing the fluid from a separation pipeline into an enrichment pipeline, wherein the enrichment pipeline includes a first section and a second section segment, the inlet of the first segment is connected to at least one first inlet, and the outlet of the second segment is connected to the first segment; at least one first separation module intercepts the target substance in the fluid; wherein, the The first separation module has a first side and a second side separated by the first separation component, opposite ends of the first side are respectively connected to the first section and the second section, and the second side is connected to at least one first row a flow port; based on at least one first driving device, the fluid is driven to circulate and flow in the enrichment pipeline at a preset flow rate to enrich the target substance, wherein the at least one first driving device is arranged in the first section and controls all the The total amount of fluid in the enrichment pipeline is dynamically balanced.
  • the second aspect of the present application also provides an embodiment of cascading the separation line and the enrichment line.
  • FIG. 15a and FIG. 15b are simplified structural diagrams of cascaded separation pipelines and enrichment pipelines in different embodiments.
  • the fluid is drawn out from one separation pipeline to the corresponding enrichment pipeline.
  • the first inlet is shown in Figure 15a, for example; or, the fluid will be processed in a cascaded separation pipeline of more than N phases, and the fluid in the last separation pipeline will be connected to the enrichment tube according to the connection sequence.
  • the fluid flows from the inlet of the separation pipeline 21 to the first inlet corresponding to the enrichment pipeline 11, and in the enrichment pipeline 11 flows to the first discharge port through the first separation module 12, and the fluid drawn from the first discharge port flows to the outlet of the separation pipeline 21 to form a separation cycle; that is, in this example, the rich
  • the header line 11 can be regarded as a sub-cycle device in the separation cycle.
  • FIG. 16 shows a flowchart of steps included in an embodiment of the fluid processing method of the second aspect of the present application.
  • step S40 the fluid from a separation pipeline is introduced into an enrichment pipeline, wherein the enrichment pipeline includes a first section and a second section, and the inlet of the first section is connected to at least one first section. an inlet, the outlet of the second section communicates with the first section;
  • step S41 the target substance in the fluid is intercepted based on at least one first separation module; wherein, the first separation module has a first side and a second side separated by the first separation module, and the first side is opposite to The two ends are respectively connected to the first section and the second section, and the second side is connected to at least one first discharge port;
  • step S42 the at least one first driving device drives the fluid to circulate and flow in the enrichment pipeline at a preset flow rate to enrich the target substance, wherein the at least one first driving device is arranged in the first section and The dynamic balance of the total amount of fluid in the enrichment line is controlled.
  • the first separation component is a porous membrane, a reverse osmosis membrane, or a gas separation membrane.
  • the average pore size or molecular cut-off of the porous membrane or reverse osmosis membrane is related to the target substance, wherein the porous membrane includes a microfiltration membrane, an ultrafiltration membrane, or nanofiltration membranes.
  • the first separation module comprises one or more of flat membranes, tubular membranes, rolled membranes, spiral membranes, and hollow fiber membranes.
  • the first separation module is a tangential flow filtration module.
  • the at least one first driving device controls the flow rate of the first section to be above a preset threshold, so that the target substance in the first separation module is removed from the The outlet of the first section flows to the inlet of the second section.
  • the preset threshold value is related to at least one of fluid composition, fluid temperature, membrane structure, membrane material, cavity structure of the first separation module, and enrichment pipeline diameter related.
  • the second segment is further provided with the first driving device.
  • the total volume or total velocity of fluid introduced into the enrichment line from the first inlet is equal to the total volume or velocity of fluid drawn out of the enrichment from the first outlet
  • the total volume or total velocity of fluid in the lines is equalized to cyclically enrich the target species.
  • the enrichment efficiency is adjusted by controlling the ratio of the total amount of fluid introduced into the enrichment pipeline per unit time to the total amount of fluid in the enrichment pipeline.
  • the enrichment pipeline is further provided with a flow channel adjustment device for adjusting the flow direction of the fluid in the enrichment pipeline; wherein, the flow channel adjustment device
  • the fluid flow direction in the enrichment pipeline can be adjusted in at least one of the following ways:
  • Adjust the fluid flow direction by adjusting the opening state of the first inlet or/and the first outlet;
  • the fluid flow direction is adjusted by adjusting the open state of at least one adjustment pipe connected to the enrichment pipe.
  • the flow channel adjustment device includes a pipeline switch provided at the first inlet for controlling the opening state of the first inlet to adjust the The processing state of the fluid in the enrichment line is switched to the enrichment circulation mode or the cleaning mode.
  • the flow channel adjustment device further includes at least one adjustment pipeline and a pipeline switch, so that a cleaning liquid inlet and a waste liquid outlet are formed in the enrichment pipeline.
  • the flow channel adjustment device is a four-way valve.
  • the enrichment pipeline is switched between a concentration circulation mode and a dilution mode to adjust the separation efficiency of the first separation module.
  • the enrichment pipeline further includes an exhaust gas inlet, which is provided in the first section or/and the second section, and is used for adjusting the enrichment pipeline The gas state or air pressure state inside the road.
  • the enrichment pipeline further includes at least one collecting device, which is arranged in the first section or/and the second section, and is used to adjust the enrichment pipeline volume to collect target substances, or to collect air bubbles.
  • the enrichment pipeline further comprises a control device, a fluid storage device, a pressure detection device, a temperature detection device, a temperature control device, an oxygen detection device, a bubble detection and removal device, At least one of an alarm device, a flow rate detection device, and a concentration detection device.
  • control device forms adjustment information for the inner working state of the enrichment pipeline based on at least one of a flow rate detection device, a pressure detection device, and a concentration detection device.
  • the specific structures of the enrichment pipeline and the first separation module, the different structures configured in the enrichment pipeline or the connection between modules, the positional relationship, and the first drive device are used to control the enrichment pipeline.
  • the way of removing the fluid, and the structure of the flow channel adjustment device, the collecting device and other equipment configured in the enrichment pipeline and the way of coordinating with each structure to realize different fluid processing functions can be referred to the first aspect of this application.
  • the enrichment pipeline, the first drive device, and the first separation module described in the embodiments of the second aspect of the present application may be the enrichment described in any one of the embodiments shown in FIG. 1 to FIG. 9 .
  • the second aspect of the present application further includes the step of pre-processing or re-processing the fluid by at least one processing module, wherein the pre-processing or re-processing includes filtration, adsorption, heating, catalysis , at least one of enrichment, concentration, chemical treatment, optical treatment, and electrical treatment.
  • the processing modules are, for example, an adsorption device, an extraction device, an ion exchange processing device, a centrifugal device, a filtering device, a heating device, and the like.
  • the processing module pretreats the fluid, ie, processes the initially obtained fluid, so as to introduce the processed fluid into the second separation module through the second inlet.
  • the fluid processed by the processing module is connected to the second inlet corresponding to the separation pipeline, and the processing module performs preprocessing.
  • the processing module reprocesses the fluid, that is, processes the separation fluid in the separation pipeline, so as to process the target substance obtained from the circulating separation.
  • the The separation fluid contains only specific components, and the specific components can be reprocessed in combination with the processing module, such as concentration collection, chemical decomposition, etc.;
  • the processing of the fluid drawn from the second row of flow outlets is reprocessing; alternatively, the reprocessing is that the processing module processes the target substances that are circulated and enriched in the enrichment pipeline, or the first row corresponding to the enrichment pipeline is processed.
  • the fluid drawn from the orifice is processed.
  • the type of preprocessing or reprocessing performed by the processing module may be determined based on processing needs. For example, when the component retained at the first side of the second separation module is a fluid component that needs to be filtered out, the separation pipeline
  • the separation fluid in the separation pipeline is the beneficial component that needs to be purified, and the processing module can perform concentration processing of the fluid in the separation pipeline; for another example, the target substance in the enrichment pipeline is the component that needs to be filtered out , the treatment module can remove the target substance by chemical decomposition.
  • the second inlet port corresponding to the second separation module is connected to the first
  • the two flow ports are connected to the same storage portion, wherein the storage portion includes a fluid storage device, a container, or a human body.
  • the storage part is only used to realize the storage or communication function of the fluid introduced into the second inlet and the fluid drawn out from the second outlet. Therefore, the storage part can be a kind of container or storage
  • the space can also be the blood circulation of the human body in a specific application scenario, which is not limited in this application.
  • FIG. 17 shows a simplified schematic diagram of the cascaded separation pipeline and enrichment pipeline in one embodiment of the present application.
  • the second inlet and the second outlet are connected to the same storage part 26, which is, for example, a storage device or a container.
  • the second The driving device 23 controls the dynamic balance of the total amount of fluid in the separation pipeline 21 to perform cyclic separation
  • the first driving device 13 controls the dynamic balance of the total fluid in the enrichment pipeline 11 to perform cyclic enrichment.
  • the total amount of fluid in the storage unit 26 is dynamically balanced.
  • the fluid in the storage part 26 is separated into specific components at the second separation module 22, that is, the separation fluid, and the separated fluid is introduced into the enrichment pipeline 11, and the enrichment pipeline 11 is enriched in the circulation
  • the separation fluid is enriched with the target substance in the enrichment pipeline 11, and the fluid separated from the target substance components is returned to the outlet of the separation pipeline 21 through the second side of the first separation module, and based on the
  • the reversible cyclic separation in the separation pipeline 21 returns to the storage part 26, and the cyclic separation and cyclic enrichment are continued, and the target substance in the fluid in the storage part 26 gradually decreases while the total amount of fluid remains unchanged.
  • the components are collected, no waste liquid is generated, and the total amount of fluid in the storage part 26 remains unchanged, so the process of cyclic separation and cyclic enrichment can continue.
  • the fluid when the storage part is a human body, can be human blood, plasma, serum, tissue fluid or other body fluids.
  • the second inlet and the first row The connection relationship between the flow port and the human body can be a direct connection or an indirect connection.
  • the first outlet is connected to a processing module, the processing module is connected to the human circulatory system, for example, the processing module is used to separate human whole blood into plasma, and the second inlet is connected to the separation obtained of blood plasma.
  • waste plasma is not generated when the pathogenic factors that need to be filtered out in the plasma are trapped in the enrichment pipeline, and based on the continuous separation treatment of the plasma in the human body, namely It can change the concentration of the target substance in the plasma of the human body and avoid the problem of continuous loss of beneficial components.
  • the separation pipeline or the enrichment pipeline can be used as a separation module. It is easy to understand that both the separation pipeline and the enrichment pipeline can achieve the separation effect based on the corresponding separation module. Therefore, , the separation pipeline and the enrichment pipeline can be used as a separation device or a filter device.
  • the second inlet of the separation pipeline is connected to the human blood circulation system, and the cell components in the blood are trapped on the first side of the second separation module based on the second separation module, and the second separation module passes through the second separation module.
  • the plasma of the separation component circulates in the separation pipeline, and at the same time, the plasma in the separation pipeline is connected to the first inlet of the enrichment pipeline, so that the target substance in the plasma can be enriched.
  • the fluid drawn from the first discharge port of the enrichment pipeline is the purified plasma, which is returned to the separation pipeline after purification and can be based on the reversible circulating separation flow of the separation pipeline. to the first side of the second separation module, whereby the purified plasma can be mixed with cellular components and returned to the human blood circulation system.
  • the removal process of pathogenic factors in plasma is sustainable, and no waste liquid is generated during the plasma purification process; at the same time, other components other than pathogenic factors in plasma can be separated back to the upstream tube based on reversible circulation.
  • the pipeline can be returned to the human body, and the construction method of the pipeline system in practical applications is also simplified.
  • control device is arranged in the enrichment pipeline or the control device is arranged in the separation pipeline, which does not limit the position of the control device, only when all the
  • the control device can be electrically connected with each driving device, detection device or sensor in the enrichment pipeline or separation pipeline, so the control device can of course be located outside the pipeline; the control device is used to obtain the enrichment pipeline.
  • the working state information in the pipeline or the separation pipeline is realized, and the control of the working state in the enrichment pipeline or the separation pipeline is realized.
  • the separation fluid in the separation line is communicated to the first inlet of the enrichment line, and in some examples, the control device is to control the A central system of cascaded separation pipelines and enrichment pipelines, where the control device simultaneously connects the separation pipelines and the enrichment pipelines; in other examples, the separation pipelines and the enrichment pipelines
  • the headers can also be connected to different controls.
  • step S30 and step S31 in the fluid processing method is not necessarily limited.
  • steps S30 and S31 can be regarded as necessary conditions for the execution of the fluid processing method provided in the second aspect of the present application, and the fluid processing method can be implemented if each condition is satisfied.
  • the sequence of occurrences between the two There is no restriction on the sequence of occurrences between the two, and the implementation manner from step S30 to step S31 here is only a description manner selected for ease of understanding.
  • step S40 , step S41 and step S42 can also be used as processing conditions in the enrichment pipeline, and the corresponding actual execution sequence can also be changed accordingly, which will not be repeated here.
  • the fluid treatment method is used in the treatment of diseases, for example, the enrichment and selective removal of target molecules can be achieved by an extracorporeal circulation removal system that can perform the fluid treatment method of the present application
  • target molecules are often pathogenic factors or results in the development of diseases, or are critical to the development of diseases or maintenance of health, and the removal of target molecules is beneficial to the treatment of diseases or the reduction of complications
  • the said Diseases include but are not limited to familial hypercholesterolemia, hyperlipoproteinemia, systemic lupus erythematosus, autoimmune disease, myasthenia gravis, rapidly progressive glomerulonephritis, fatty liver, cirrhosis, acute liver failure, hyperthyroidism
  • the type of disease that the fluid handling method is adapted to treat is not limited to the foregoing examples, only if the type of disease that the fluid handling method is adapted to treat is not limited to the foregoing examples, only if the type of disease that the fluid handling method is adapted to treat is not limited to the fore
  • the target substance in the blood or tissue fluid can be continuously circulated by determining the patient's lesions such as pathogenic factors in blood or other pathogenic factors in tissue fluid separation, thereby changing the concentration of pathogenic factors in the patient's body.
  • a corresponding separation module is selected or designed to determine the pathogenic factor in the blood or tissue fluid for a specific disease type, that is, the specific pathogenic factor is circulated in the separation pipeline, and the pathogenic factor can be combined with the processing module. to be processed.
  • the blood or tissue fluid drawn from the patient can also be pretreated by the processing module, and then the target substance in the blood or tissue fluid obtained by the pretreatment can be enriched or removed, and the control can be based on a preset removal target. processing time.
  • the target substance enriched by the enrichment circuit circulation or the separation fluid separated by circulation in the separation circuit can also be connected to a processing module for reprocessing, which can treat the target Substances or separated fluids are decomposed, reacted, heated, concentrated, etc.
  • the components in the fluid are intercepted by the second separation module and the specific components in the fluid are circulated and separated in the separation pipeline.
  • the separation pipeline The fluid in the fluid flows at a preset flow rate according to the second driving device, so as to ensure the dynamic balance of the total amount of fluid in the separation pipeline, so that the fluid treatment method of the present application is sustainable in the treatment, and can achieve the target of the fluid medium.
  • the collection of substances or the change of the concentration of fluid components can be realized, and the fluid or separated fluid drawn from the second discharge port of the separation pipeline can be connected to the processing module or storage space, which avoids the separation or exchange of components during the process of fluid component separation or exchange. Continued loss of beneficial ingredients.
  • the fluid processing method can be based on cascaded separation pipelines or phase cascaded separation pipelines and enrichment pipelines to achieve the processing of target components in the fluid under fine-grained classification, and at the same time , based on the reversible circulation characteristics of the separation pipeline, the target molecules or the preset specific components that need to be removed or treated can be trapped in different cycles, and other fluid components that do not need to be treated can flow to Upstream pipelines, thereby enabling targeted and selective enrichment, removal, collection or other processing of specific components, while avoiding the problem of the separation effect decreasing over time.
  • the fluid treatment method can be used to achieve the collection or treatment of any component in the fluid, which can eliminate or reduce application limitations in different fields, such as in medical applications, can be used for human body fluids (including blood) Different components in the water are collected or processed, different active ingredients are enriched in the pharmaceutical process, and different solutes are enriched, separated, and processed in the water treatment.
  • the present application further provides a fluid processing device in a third aspect, comprising at least one circulation enrichment module, wherein the circulation enrichment module includes: an enrichment pipeline, including a first section and a second section; wherein, the The inlet of the first section communicates with the first inlet, and the outlet of the second section communicates with the first section; at least one first separation module includes a first separation component to separate the first separation module to form a second separation module.
  • One side and the second side wherein the opposite ends of the first side are respectively connected to the first section and the second section; the second side is connected to at least one first discharge port; at least one first driving device is provided.
  • the first section for driving the fluid circulation flow of the enrichment pipeline to control the dynamic balance of the total amount of fluid in the enrichment pipeline, so that the first separation module is in the enrichment cycle mode
  • the target substance is enriched.
  • the circulation enrichment module includes: an enrichment pipeline 11, including a first section 111 and a second section 112; wherein the inlet of the first section 111 is connected to the first inlet, and the outlet of the second section 112 Connect the first segment.
  • the first section 111 and the second section 112 of the enrichment pipeline 11 can be based on a certain connection relationship, so that the direction of the liquid flow in the enrichment pipeline 11 can form a cycle, and the outlet of the second section 112 is communicated In the first section 111 , after the fluid enters the first section 111 from the first inlet, it can flow to the second section 112 and from the outlet of the second section 112 to the first section 111 . form a flow cycle.
  • the at least one first separation module 12 includes a first separation component to separate the first separation module 12 to form a first side and a second side, wherein the first side communicates with the outlet of the first section 111 and the second side.
  • the inlet of the second section 112; the second side communicates with at least one first discharge port.
  • the fluid comprises a target substance
  • the fluid includes blood, plasma, serum, body fluid, tissue fluid, washing fluid, dialysate, recombinant protein solution, cell culture fluid, microbial culture fluid Liquid, pharmaceutical and medical water, liquid medicine, fluid food, animal and plant extract, natural water, industrial wastewater, reclaimed water, methane, light oil, and a mixture of one or more of liquefied gas.
  • the first separation component is a porous membrane, a reverse osmosis membrane, or a gas separation membrane.
  • the average pore size or molecular cut-off of the porous membrane or reverse osmosis membrane is related to the target substance, wherein the porous membrane includes a microfiltration membrane, an ultrafiltration membrane, and nanofiltration membranes.
  • the first separation module comprises one or more of flat membranes, tubular membranes, rolled membranes, spiral membranes, and hollow fiber membranes.
  • the first separation module is a tangential flow filtration module.
  • the at least one first driving device controls the flow rate of the first section to be greater than a preset threshold, so that the target substance in the first separation module is removed from the The outlet of the first section flows to the inlet of the second section.
  • the preset threshold is related to at least one of fluid composition, fluid temperature, membrane structure, membrane material, cavity structure of the first separation module, and enrichment pipeline diameter related.
  • the second section of the circulation enrichment module is further provided with the first driving device.
  • the total volume or total velocity of the fluid introduced into the enrichment pipeline from the first inlet is the same as the total volume or velocity of the fluid introduced into the enrichment pipeline from the first exhaust.
  • the total volume or total rate of fluid exiting the enrichment line is equal.
  • the circulating enrichment module adjusts the ratio of the total amount of fluid introduced into the enrichment pipeline per unit time to the total amount of fluid in the enrichment pipeline. enrichment efficiency.
  • the enrichment pipeline is further provided with a flow channel adjustment device for adjusting the flow direction of the fluid in the enrichment pipeline; wherein, the flow channel adjustment device
  • the flow direction of the fluid in the enrichment pipeline can be adjusted in at least one of the following ways: by adjusting the opening state of the first inlet or/and the first outlet to adjust the flow direction of the fluid; by adjusting the connection to the enrichment pipe At least one of the channels adjusts the open state of the conduit to adjust the flow direction of the fluid.
  • the flow channel adjustment device includes a pipeline switch provided at the first inlet, for controlling the opening state of the first inlet to adjust the The processing state of the fluid in the enrichment line is switched to the enrichment circulation mode or the cleaning mode.
  • the flow channel adjustment device further includes at least one adjustment pipe and a pipe switch, so that a cleaning liquid inlet and a waste liquid outlet are formed in the enrichment pipe.
  • the flow channel adjustment device is a four-way valve.
  • the circulation enrichment module is switched between a concentration circulation mode and a dilution mode based on the flow channel adjustment device, so as to adjust the separation efficiency of the first separation module.
  • the circulation enrichment module further comprises an exhaust gas inlet, which is arranged in the first section or/and the second section, and is used for adjusting the enrichment pipe The gas state or air pressure state inside the road.
  • the circulation enrichment module further comprises at least one collecting device, which is arranged in the first section or/and the second section, and is used for adjusting the enrichment pipe volume to collect target substances, or to collect air bubbles.
  • the circulation enrichment module further includes a control device, a fluid storage device, a flow rate detection device, a pressure detection device, a temperature detection device, a temperature control device, an oxygen detection device, and a bubble detection device. And at least one of the exclusion device, the alarm device, and the concentration detection device.
  • control device forms adjustment information for the inner working state of the enrichment pipeline based on at least one of a flow rate detection device, a pressure detection device, and a concentration detection device.
  • the first inlet and the first outlet are connected to the same storage portion, wherein the storage portion includes a fluid storage device, a container, and a human body.
  • the circulation enrichment module may be a hardware device for implementing the fluid processing methods described in some embodiments provided in the first aspect of the present application, for example, a An apparatus for forming an enrichment cycle in the fluid treatment method described in any one of the embodiments of 1 to 12 .
  • the fluid treatment device includes N phase-cascaded circulating enrichment modules, where N is a positive integer of 2 or more;
  • N is a positive integer of 2 or more;
  • the first flow outlet of the former circulation enrichment module is connected to the first inlet of the latter circulation enrichment module.
  • connection method between different circulation enrichment modules in the fluid processing device, the processing method for the fluid, and the processing effect can refer to the embodiment provided in the first aspect of the present application.
  • FIG. 9 can be shown as a phase cascade Simplified schematic diagram of the Cyclic enrichment module.
  • the molecular particle size, molecular weight, or component particle size of the N cascaded cyclic enrichment modules corresponding to the enriched target substances decreases step by step according to the connection order.
  • the phase cascaded circulation enrichment module may be a device for implementing the fluid processing method of cascading multiple enrichment pipelines in the embodiment provided in the first aspect of the present application. For specific implementation and processing effects, refer to the first aspect. The provided embodiments are not repeated here.
  • the fluid treatment device further includes at least one circulation separation module, wherein the circulation separation module includes: a separation pipeline having an inlet and an outlet; a second separation module including The second separation component separates the second separation module to form a first side and a second side, wherein opposite ends of the first side of the second separation module are respectively connected to at least one second inlet and at least one second row an outlet, the opposite ends of the second side of the second separation module are respectively connected to the inlet and outlet of the separation pipeline; the second inlet is connected to the first outlet of the circulating enrichment module; at least one The second driving device is arranged in the separation pipeline, and is used for driving the fluid in the separation pipeline to flow from the inlet to the outlet at a preset flow rate, so as to dynamically balance the total amount of fluid in the separation pipeline in the circulation separation mode .
  • the circulation separation module includes: a separation pipeline having an inlet and an outlet; a second separation module including The second separation component separates the second separation module to form a first side and a second side, wherein opposite ends
  • connection method and positional relationship between the separation pipeline, the second separation module and the second drive device in the circulation separation module can refer to the embodiments shown in FIGS. 11 to 12 , and the circulation separation module can be formed in FIGS.
  • the separation cycle (also referred to as cycle separation) in any of the embodiments shown.
  • the fluid introduced from the second inlet can enter the separation pipeline 21 through the separation fluid of the second separation component to form a circulation, and the second outlet is connected to the second outlet.
  • a reversible cycle separation is formed in the cycle separation module.
  • the second separation component is a porous membrane, a reverse osmosis membrane or a gas separation membrane.
  • the average pore size or molecular cut-off of the porous membrane or reverse osmosis membrane is related to the fluid composition, wherein the porous membrane comprises a microfiltration membrane, an ultrafiltration membrane, and nanofiltration membranes.
  • the second separation module comprises one or more of sheet membranes, tubular membranes, rolled membranes, spiral membranes, and hollow fiber membranes.
  • the second separation module is a tangential flow filtration module.
  • the circulation separation module further includes a control device, a fluid storage device, a pressure detection device, a temperature detection device, a temperature control device, an oxygen detection device, a bubble detection and removal device, an alarm at least one of a device and a concentration detection device.
  • the circulation separation module may be a device for forming a separation cycle in the fluid processing method in the embodiments provided in the first aspect of the present application, so as to be used in the circulation separation mode described in the first aspect of the present application Handling fluids.
  • a third aspect of the present application provides an embodiment of a fluid treatment device having a cascade of circulating enrichment modules and circulating separation modules.
  • the fluid is led out from the first discharge port of one circulation enrichment module to the corresponding second inlet port of the circulation separation module; or, the fluid is cascaded in more than N phases Processed in the circulating enrichment module of the above, and conforming to the connection sequence, the first flow outlet of the last circulating enrichment module is connected to the second inlet corresponding to the circulating separation module, wherein, N is a positive integer of 2 or more.
  • the fluid treatment device further comprises at least one treatment module for pre-processing or re-processing the fluid in the fluid-processing device, wherein the pre-processing or re-processing Treatment includes at least one of filtration, adsorption, heating, catalysis, enrichment, concentration, chemical treatment, optical treatment, and electrical treatment.
  • the processing module pretreats the fluid, that is, processes the initially obtained fluid, and introduces the processed fluid into the circulation enrichment module through the first inlet, and the processing module performs the preprocessing. processing; the processing module reprocesses the fluid, that is, processing the fluid or the target substance in the circulating enrichment module or processing the fluid drawn from the first discharge outlet; or, the processing module separates the circulating
  • the processing of the fluid at the second inlet in the module, the processing of the fluid in the separation pipeline, or the processing of the fluid drawn from the second outlet in the circulating separation module can be regarded as reprocessing.
  • the fluid processing device is an extracorporeal circulation device, wherein the extracorporeal circulation device includes but is not limited to hemodialysis equipment, plasma exchange equipment, extracorporeal peritoneal dialysis equipment, or extracorporeal peritoneal dialysis equipment Membrane oxygenation equipment.
  • the extracorporeal circulation device is used alone as a medical device or a treatment device, and can also be integrated into a medical device or device involving extracorporeal treatment of blood or other body fluids to form a new device.
  • the extracorporeal circulation device can be used as a device for selectively processing various tissue fluids, blood, plasma and their specific components from the human body. Based on the characteristics of the fluid treatment device being sustainable and not producing waste fluid and losing beneficial small molecules, the extracorporeal circulation device can collect specific components or change the concentration of specific components during the treatment of human tissue fluid or blood. , or remove specific components, and make other components back into the human body to form tissue fluid or form extracorporeal circulation treatment of blood.
  • the fluid treatment device is used for disease treatment.
  • the manner in which the fluid treatment device realizes disease treatment and the corresponding feasible treatment types may refer to the embodiments provided in the first aspect of the present application, which will not be repeated here.
  • the fluid treatment device provided in the third aspect of the present application may be a device for performing the fluid treatment method described in any one of the embodiments provided in the first aspect of the present application.
  • the specific structure, connection method, connection method with the processing module, and the fluid processing effect achieved by the circulating enrichment module and the circulating separation module in the fluid processing device can all refer to the implementation provided in the second aspect of this application. example.
  • the recycle enrichment module or the recycle separation module in the fluid treatment device can be used as a separate sales unit; here, the fluid treatment device can be represented as a connected device or as available
  • An independent component of the connection relationship that is, an independent circulation enrichment module or a circulation separation module
  • the connection relationship can be one or more, for example, the fluid treatment device includes a plurality of circulation enrichment modules and circulation separation modules , the cycle enrichment module and the cycle separation module can be connected in different connection relationships to suit different processing requirements, or, to suit the needs of scenarios, and optionally only some of the components among the multiple components to connect.
  • the present application further provides a circulation separation device for fluid processing, the circulation separation device includes at least one circulation separation module, wherein the circulation separation module includes: a separation pipeline with an inlet and an outlet a second separation module, comprising a second separation component to separate the second separation module to form a first side and a second side, wherein the opposite ends of the first side of the second separation module are respectively connected to at least one second inflow port and at least one second discharge port, the opposite ends of the second side of the second separation module are respectively connected to the inlet and outlet of the separation pipeline; at least one second driving device is provided in the separation pipeline for The fluid in the separation line is driven to flow from the inlet to the outlet at a preset flow rate, so as to dynamically balance the total amount of fluid in the separation line in the circulating separation mode.
  • the circulation separation module includes: a separation pipeline with an inlet and an outlet a second separation module, comprising a second separation component to separate the second separation module to form a first side and a second side, wherein the opposite ends of the first side
  • FIG. 12 is a simplified schematic diagram of the cycle separation module in one embodiment.
  • the fluid introduced from the second inlet can enter the separation pipeline 21 through the separation fluid of the second separation component to form a circulation, and the second outlet is connected to the second outlet.
  • a reversible cycle separation is formed in the cycle separation module.
  • the fluid comprises a target substance
  • the fluid includes blood, plasma, serum, body fluid, tissue fluid, washing fluid, dialysate, recombinant protein solution, cell culture fluid, microbial culture fluid Liquid, pharmaceutical and medical water, liquid medicine, fluid food, animal and plant extract, natural water, industrial wastewater, reclaimed water, methane, light oil, and a mixture of one or more of liquefied gas.
  • the second separation component is a porous membrane, a reverse osmosis membrane or a gas separation membrane.
  • the average pore size or molecular cut-off of the porous membrane or reverse osmosis membrane is related to the fluid composition, wherein the porous membrane includes a microfiltration membrane, an ultrafiltration membrane, and nanofiltration membranes.
  • the second separation module includes one or more of sheet membranes, tubular membranes, rolled membranes, spiral membranes, and hollow fiber membranes.
  • the second separation module is a tangential flow filter module.
  • the circulation separation module further includes a control device, a fluid storage device, a pressure detection device, a temperature detection device, a temperature control device, a bubble detection and removal device, an alarm device, and a concentration At least one of detection devices.
  • the circulating separation device further comprises at least one processing module, for performing a step of pre-processing or re-processing on the fluid, wherein the pre-processing or re-processing comprises filtering , at least one of adsorption, heating, catalysis, enrichment, concentration, chemical treatment, optical treatment, and electrical treatment.
  • the processing modules are, for example, an adsorption device, an extraction device, an ion exchange processing device, a centrifugal device, a filtering device, a heating device, and the like.
  • the processing module may be disposed in the separation pipeline to adjust the flow direction or flow channel of the separation fluid, that is, the processing module may also be Flow path adjustment device.
  • the processing module in the recycle separation module may also be a collection device.
  • the cycle separation module in the cycle separation device provided in the fourth aspect of the present application may be an execution device or an execution module for forming the separation cycle in any of the embodiments provided in the second aspect of the present application.
  • the processing effect in the embodiment provided by the second aspect of the application is applied.
  • the circulatory separation device includes N phase cascaded circulatory separation modules, and N is a positive integer greater than or equal to 2;
  • the separation pipeline of the preceding circulation separation module is connected to the second inlet and the second outlet of the latter circulation separation module.
  • the molecular particle size, molecular weight, or component particle size of the target substance corresponding to the N phase cascaded cyclic separation modules decreases step by step according to the connection order.
  • the structure and connection method of the circulating separation modules cascaded with N phases, as well as the processing method of the fluid may refer to this application
  • the second aspect provides an embodiment of cascading a plurality of separation pipelines, for example, any implementation manner of the embodiments shown in FIG. 14 .
  • the circulating separation device further includes at least one circulating enrichment module, wherein the circulating enrichment module includes: an enrichment pipeline, including a first section and a second section ; wherein, the inlet of the first section is connected to the first inlet, and the outlet of the second section is connected to the first section; at least one first separation module is connected to the outlet of the first section, including the first a separation assembly to separate the first separation module to form a first side and a second side, wherein the first side communicates with the inlet of the second section; the second side communicates with at least one first discharge port;
  • the first inlet is connected to the separation pipeline of the circulating separation module; at least one first driving device is arranged in the first section, and is used to drive the fluid circulating flow of the enrichment pipeline to control all the The total amount of fluid in the enrichment pipeline is dynamically balanced, so that the first separation module can enrich the target substance in the enrichment cycle mode.
  • the circulation enrichment module includes: an enrichment pipeline 11, including a first section 111 and a second section 112; wherein the inlet of the first section 111 is connected to the first inlet, and the outlet of the second section 112 Connect the first segment.
  • the first section 111 and the second section 112 of the enrichment pipeline 11 can be based on a certain connection relationship, so that the direction of the liquid flow in the enrichment pipeline 11 can form a cycle, and the outlet of the second section 112 is communicated In the first section 111 , after the fluid enters the first section 111 from the first inlet, it can flow to the second section 112 and from the outlet of the second section 112 to the first section 111 . form a flow cycle.
  • the at least one first separation module 12 includes a first separation component to separate the first separation module 12 to form a first side and a second side, wherein the first side communicates with the outlet of the first section 111 and the second side.
  • the inlet of the second section 112; the second side communicates with at least one first discharge port.
  • the fourth aspect of the present application also provides an embodiment of a recycle separation device in which a recycle separation module and a recycle enrichment module are cascaded.
  • the circulation separation device includes a cascaded circulation separation module and a circulation enrichment module
  • the structure and connection method of the circulation separation module and the circulation enrichment module, as well as the processing method of the fluid can refer to this chapter.
  • the second aspect of the application provides the embodiment of cascading the separation pipeline and the enrichment pipeline, for example, any one of the implementations in the embodiments shown in FIGS. 15 a and 15 b .
  • the first separation component is a porous membrane, a reverse osmosis membrane, or a gas separation membrane.
  • the average pore size or molecular cut-off of the porous membrane or reverse osmosis membrane is related to the target substance, and the porous membrane includes microfiltration membranes, ultrafiltration membranes, and nanofiltration membranes. filter membrane.
  • the first separation module comprises one or more of flat membranes, tubular membranes, rolled membranes, spiral membranes, and hollow fiber membranes.
  • the first separation module is a tangential flow filtration module.
  • the at least one first driving device controls the flow rate of the first section to be above a preset threshold, so that the target substance in the first separation module is removed from the The outlet of the first section flows to the inlet of the second section.
  • the preset threshold value is associated with at least one of fluid composition, fluid temperature, membrane structure, membrane material, cavity structure of the first separation module, and enrichment pipeline diameter related.
  • the second segment is further provided with the first driving device.
  • the total volume or total velocity of the fluid introduced into the enrichment pipeline from the first inlet is equal to The total volume or total velocity of the fluid drawn out of the enrichment pipeline from the first outflow port is equal.
  • the circulating enrichment module adjusts the ratio of the total amount of fluid introduced into the enrichment pipeline per unit time to the total amount of fluid in the enrichment pipeline. enrichment efficiency.
  • the circulation enrichment module further includes a flow channel adjustment device, which is arranged in the first section or/and the second section, and is used for adjusting the enrichment pipe
  • the flow direction of the fluid in the pipeline wherein the flow channel adjustment device can adjust the flow direction of the fluid in the enrichment pipeline in at least one of the following ways: by adjusting the open state of the first inlet or/and the first outlet To adjust the fluid flow direction; adjust the fluid flow direction by adjusting the open state of at least one adjustment pipe connected to the enrichment pipeline.
  • the flow channel adjustment device includes a pipeline switch provided at the first inlet, for controlling the opening state of the first inlet to adjust the The fluid in the enrichment line is switched to the enrichment cycle mode or to the purge mode.
  • the flow channel adjustment device further includes at least one adjustment pipe and a pipe switch, so that a cleaning liquid inlet and a waste liquid outlet are formed in the enrichment pipe.
  • the flow channel adjustment device is a four-way valve.
  • the enrichment pipeline is switched between a concentration circulation mode and a dilution mode based on the flow channel adjustment device, so as to adjust the separation efficiency of the first separation module.
  • the circulation enrichment module further comprises an exhaust gas inlet, which is arranged in the first section or/and the second section, and is used for adjusting the enrichment pipe The gas state or air pressure state inside the road.
  • the circulation enrichment module further comprises at least one collecting device, which is arranged in the first section or/and the second section, and is used to adjust the enrichment pipe volume to collect target substances, or to collect air bubbles.
  • the circulation enrichment module further includes a control device, a fluid storage device, a pressure detection device, a temperature detection device, a temperature control device, a bubble detection and removal device, an alarm device, and At least one of the concentration detection devices.
  • the circulation enrichment module further includes a flow rate detection device, which is used to detect the dynamic state inside the enrichment pipeline, so as to form an internal working condition of the enrichment pipeline. Status adjustment information.
  • the cycle enrichment module in the cycle separation device provided in the fourth aspect of the present application may be an execution device or an execution module for forming the enrichment cycle in any of the embodiments provided in the second aspect of the present application.
  • the processing effects in the embodiments provided in the second aspect of the present application will not be repeated here.
  • the separation cycle device further includes at least one treatment module for pre-processing or re-treatment of the fluid in the cycle separation device, wherein the pre-treatment or Reprocessing includes at least one of filtration, adsorption, heating, catalysis, enrichment, concentration, chemical treatment, optical treatment, and electrical treatment.
  • the processing modules are, for example, an adsorption device, an extraction device, an ion exchange processing device, a centrifugal device, a filtering device, a heating device, and the like.
  • the processing module pre-processes the fluid that is initially obtained, and introduces the processed fluid into the circulation separation module through the second inlet, and the processing module performs pre-processing ;
  • the processing module reprocesses the fluid, that is, the separation flow in the circulating separation module is processed or the fluid drawn from the second discharge outlet is processed;
  • the treatment of the fluid at an inlet, the treatment of the fluid in the enrichment pipeline, or the treatment of the fluid drawn from the first outlet in the circulation enrichment module can be regarded as reprocessing.
  • the circulation separation device is an extracorporeal circulation device, wherein the extracorporeal circulation device is hemodialysis equipment, plasma exchange equipment, extracorporeal peritoneal dialysis equipment, or extracorporeal membrane oxygenation equipment. It should be understood that the types of devices that can be formed by the extracorporeal circulation device are not limited thereto.
  • the circulatory separation device is used alone as a medical device or a treatment device, and can also be integrated into a medical device or device involving extracorporeal treatment of blood or other body fluids to form a new device.
  • the circulation separation device is used in the treatment of diseases, such as achieving therapeutic effects through enrichment and selective removal of target molecules, and the circulation separation device achieves disease treatment methods and
  • diseases such as achieving therapeutic effects through enrichment and selective removal of target molecules
  • the circulation separation device achieves disease treatment methods and
  • the circulating separation device provided in the fourth aspect of the present application may be a device for performing the fluid processing method described in any one of the embodiments provided in the second aspect of the present application.
  • the specific structure, connection method, connection method with the processing module, and fluid treatment effect of the circulating separation module and the circulating enrichment module in the circulating separation device can all refer to the implementation provided in the second aspect of this application. example.
  • the recycle separation module or the recycle enrichment module in the recycle separation device can be used as an independent sales unit; here, the recycle separation device can be represented as a connected device or as available
  • An independent component of the connection relationship that is, an independent circulation enrichment module or a circulation separation module
  • the connection relationship can be one or more, for example, the fluid treatment device includes a plurality of circulation enrichment modules and circulation separation modules , the cycle enrichment module and the cycle separation module can be connected in different connection relationships to suit different processing requirements, or, to suit the needs of scenarios, and optionally only some of the components among the multiple components to connect.
  • a circulation treatment system including at least one fluid treatment device according to any one of the embodiments provided in the third aspect of the present application or/and at least one of the fourth aspect of the present application.
  • Aspect provides the circulation separation device according to any one of the embodiments; and a pipeline system, the pipeline system includes a fluid outlet pipeline and a fluid return pipeline.
  • composition of the circulation processing system includes any one of the following:
  • Example B1 consists of one of the circulating separation devices and pipeline system;
  • Example B2 consists of two or more of the circulating separation devices and pipeline systems;
  • Embodiment C is composed of at least one of the fluid processing devices, at least one of the circulation separation devices, and a pipeline system.
  • connection between the fluid treatment devices or/and the circulation separation devices can be connected in series or in parallel; wherein, the serial connection is a connection including a sequence relationship, for example, In two fluid treatment devices connected in series, the fluid is circulated from one fluid treatment device to the next fluid treatment device after being subjected to circulatory treatment; the inflow ports of the different devices or devices connected in parallel can be connected to the same pipe
  • the same pipeline, the same container, or the same module, or, the fluids processed by different fluid treatment devices or circulating separation devices can be connected to the same pipeline, the same container, or the same module.
  • the parallel connection of the fluid treatment devices such as electrical components The parallel form between.
  • the fluid treatment device and the circulation separation device can be used to collect or process specific components in the fluid, whereby the content or concentration of the specific components in the fluid is changed, by changing the fluid treatment device or/and the circulation
  • the connection between the separation devices can achieve different effects of changing the fluid components.
  • the pipeline system further includes an anticoagulation system, a fluid storage device, a control device, a flow rate detection device, a pressure detection device, a temperature detection device, a temperature control device, and an oxygen detection device , at least one of a bubble detection and removal device, an alarm device, and a concentration detection device.
  • FIG. 18 shows a simplified schematic diagram of the circulation processing system of the present application in one embodiment.
  • the pipeline system can optionally include the above-mentioned device.
  • the pipeline system is mainly used for pulling fluids, and the above-mentioned device can be set in the pipeline system according to actual needs in different application scenarios, for example,
  • a bubble detection and removal device 31 and an air capture device can usually be provided in the pipeline system. 32.
  • the anticoagulation system 34 and the tubing system are coupled systems, for example, when the tubing system is used for blood delivery, by adding heparin, tissue fibrinolysis to the tubing system A zymogen activator, an antithrombin, and other components that inhibit coagulation, and the components that inhibit coagulation flow with the fluid in the pipeline system, that is, the pipeline system is an anticoagulant system.
  • the air bubble detection and removal device 31 can be used to ensure that the fluid is removed from air bubbles before entering the fluid processing device or the circulating separation device, or to remove air bubbles when the treated fluid is drawn out of the fluid processing device or the circulating separation device,
  • the fluid such as blood
  • the fluid needs to be freed of air bubbles after being processed before being introduced back into the human blood circulation.
  • FIG. 19 shows a simplified schematic diagram of the circulation processing system of the present application in another embodiment.
  • the circulation processing system includes a pipeline system and a fluid processing device, and the pipeline system includes a fluid outlet pipeline and a fluid return pipeline.
  • the fluid treatment device is also a circulating enrichment module.
  • the fluid outlet pipeline is connected to a processing module, which can also be a separation device, such as a tangential flow filter module or a centrifugal device, and the part of the fluid separated from the separation device is connected to the In the fluid treatment device, the fluid drawn from the first discharge outlet after being processed by the fluid treatment device is connected to the downstream of the separation device, that is, it can be merged with the retained fluid at the separation device and connected to the fluid return pipeline.
  • the fluid extraction pipeline can be used for example to extract whole blood from the human body, and the corresponding separation device separates the whole blood into cell components and whole blood.
  • a plasma component, the cellular component can be connected to a fluid return line as a retentate, the plasma component is communicated to the first inlet of the fluid treatment device, whereby the plasma component can be Certain components such as low-density lipoproteins are enriched in the fluid treatment device, and the filtrate of the plasma fraction treated by the fluid treatment device can be connected to the fluid return line, whereby the treated plasma and cells are Confluence of components achieves targeted removal (enrichment) of low-density lipoproteins in human blood whole blood; in some implementations, the cellular components and the plasma component filtrate at the fluid processing device are optional Connected to a collection device connected to the fluid return line.
  • the separation device can effectively filter out target molecules in plasma, and the fluid processing device can effectively enrich target molecules, resulting in the enrich
  • a collection device is optionally provided in the pipeline system, and an anticoagulation system 34, a pressure detection system 33, a control device, a driving device, a bubble detection and Exclusion device 31 and the like.
  • FIG. 20 shows a simplified schematic diagram of the circulation processing system of the present application in yet another embodiment.
  • the circulation processing system includes a pipeline system and a fluid processing device, and the pipeline system includes a fluid outlet pipeline and a fluid return pipeline.
  • the fluid treatment device is also a circulating enrichment module.
  • the fluid outlet pipeline is connected to a processing module, such as a filtering device or a separation device, for separating the fluid processed by the processing module into a retention fluid and a filtering fluid, which are filtered out from the processing module Or the separated filtered fluid is connected to the first inlet of the circulating enrichment module, and the fluid processed through the circulating enrichment module is drawn out from the first discharge outlet and connected to the upstream of the processing module That is, the fluid processed by the circulating enrichment module is connected to the processing module again for processing, and the retained fluid at the processing module is connected to the pipeline return pipeline.
  • a processing module such as a filtering device or a separation device
  • the circulatory treatment system is, for example, an extracorporeal circulation treatment system.
  • the blood processed by the device is returned to the human body.
  • the processing module is, for example, a filtration module, used for separating partial components such as plasma components from the whole blood drawn from the human body, and the plasma components are drawn to the first inlet of the fluid processing device through the pipeline.
  • the filtered plasma passes through the filter module again After processing, the retained tributary obtained from the filter module is, for example, renewed whole blood, and the renewed whole blood is connected to a fluid return line for delivery to the human body. That is, in this embodiment, the plasma components can be circulated through the fluid processing device, and at the same time, by setting the connection between the fluid processing device and the processing module, the filtration module can also be used to realize the circulating filtration of plasma .
  • a collection device is optionally provided in the pipeline system, and an anticoagulation system 34, a pressure detection system 33, a control device, a driving device, a bubble detection and Exclusion device 31 and the like.
  • the control device (not shown in the figure) can be used to control the temperature control device, bubble detection and elimination device, alarm device, etc. in the pipeline system, and can also be used to receive detection information such as temperature information, oxygen information in the pipeline, pressure information, etc., so as to control the working status of each device in the pipeline system, such as on or off, operating mode, operating power, etc., based on the detection information.
  • the piping system includes a fluid outlet line and a fluid return line; in certain embodiments, the fluid outlet line and the fluid return line may be connected to the same container or storage space or human body, for example, the The fluid outlet line draws blood from the human body to the fluid treatment device or the circulatory separation device, and the fluid return line returns the treated blood to the human body.
  • the tubing material in the tubing system may be set to a special material corresponding to the fluid, for example, the tubing system may be configured as a dedicated blood tubing, a dedicated tubing for a peristaltic pump, a single-use blood tubing Blood tubing for dialysis, autoclaved silicone tubing, tubing dedicated to corrosive liquids, tubing with high biocompatibility, etc.
  • the tubing system For blood delivery pipelines or liquid medicine delivery pipelines, pipeline materials include but are not limited to soft polyvinyl chloride plastics, high-performance polyolefin thermoplastic elastomers (TPE), nano-biomedical materials, and resin materials.
  • the circulatory treatment system is an extracorporeal circulation clearance system, an extracorporeal enrichment and clearance equipment, a hemodialysis equipment, a plasma exchange equipment, an extracorporeal peritoneal dialysis equipment, or an extracorporeal membrane lung oxygenation equipment
  • the circulatory treatment system can also be used as a component to be grafted into other extracorporeal circulation equipment, such as artificial liver, artificial kidney, hemodialysis equipment, peritoneal dialysis equipment, plasma exchange equipment, plasma purification equipment , blood lipid purification equipment, molecular adsorption recycling system, extracorporeal membrane oxygenation equipment, leukocyte removal equipment, extracorporeal circulation life support system, etc.
  • the circulatory treatment system alone forms a medical device or treatment device, and can also be integrated into a medical device or device involving extracorporeal treatment of blood or other body fluids to form a new device.
  • the circulating treatment system is used for at least one of cell collection, microorganism collection, and material collection.
  • both the fluid treatment device and the separation and circulation device in the circulation treatment system can collect specific components, and in specific scenarios, the specific components may be cells, microorganisms or other materials.
  • each of the fluid treatment devices or circulation separation devices can be used as an independent sales unit; by associating the fluid treatment devices with the circulation separation devices in different connection relationships, different effects on fluid treatment can be formed.
  • the circulation processing system formed by determining the connection relationship can also be used as a sales unit, and correspondingly, the circulation processing system can be expressed as a system that has been connected, or can be expressed as each independent component that can obtain a connection relationship
  • the connected system may further include an integrated housing or a module shape, for example, an interface corresponding to the pipeline system is reserved outside the housing to process the outflow.
  • the device and the circulating separation device are integrated inside the casing; or a casing that can be opened and closed is formed to introduce fluid into the circulating treatment system when the casing is opened.
  • the present application further provides a medical device, the medical device comprising the circulatory processing system according to the embodiments provided in the fifth aspect of the present application.
  • the medical equipment can be used for medical purposes, and can be instruments, equipment, appliances, materials or other items used in the human body alone or in combination, and can also include required software; Treatment, monitoring, relief, compensation.
  • the medical equipment is, for example, an extracorporeal circulation clearing system, extracorporeal enrichment clearing equipment, hemodialysis equipment, plasma exchange equipment, extracorporeal peritoneal dialysis equipment, or extracorporeal membrane oxygenation equipment;
  • the medical equipment can also be a component grafted into other extracorporeal circulation equipment, such as artificial liver, artificial kidney, hemodialysis equipment, peritoneal dialysis equipment, plasma exchange equipment, plasma purification equipment, blood lipid purification equipment. , molecular adsorption recycling system, extracorporeal membrane oxygenation equipment, leukocyte removal equipment, extracorporeal circulation life support system, etc.
  • the medical device is used alone as a medical device or therapeutic device, and can also be integrated into a medical device or device involving extracorporeal treatment of blood or other body fluids to form a new device.
  • the circulatory treatment system provided in the fifth aspect of the present application when used for medical purposes, it can be used as a medical device.
  • the medical use includes the treatment of fluids obtained based on the human body, and also includes the use of medicines in the treatment process, pharmaceutical water, medical water, etc.
  • the circulating treatment system can be used to treat tap water to obtain Dilution water for concentrated dialysate.
  • the medical device is used for disease treatment by selectively changing the concentration of specific molecules or molecular combinations, and these specific molecules or molecular combinations (also referred to as target molecules) are often It is a pathogenic factor or result in the process of disease development, or is critical to the development of disease or maintenance of health, and the control of target molecule concentration is beneficial to the treatment of disease or the control of complications, wherein the disease includes but Not limited to familial hypercholesterolemia, hyperlipoproteinemia, systemic lupus erythematosus, autoimmune disease, myasthenia gravis, rapidly progressive glomerulonephritis, fatty liver, cirrhosis, acute liver failure, hyperlipidemia At least one of severe acute pancreatitis, sepsis, Guillain-Barré syndrome, and obesity.
  • the treatment includes preventative (ie, prophylactic), curative, or palliative treatments that result in the desired physiological effect.
  • treating is used herein to mean partially or fully ameliorating, delaying the onset, inhibiting progression, lessening the severity, and/or reducing the appearance of one or more symptoms of a particular disease, abnormality and/or medical condition the purpose of probability.
  • the medical device of the present application can be used to change the concentration of a specific molecule or molecular combination in a patient, but for different disease types, the medical intervention required by the patient may include other means, for example, kidney function.
  • the medical device of this application can help to achieve the removal of pathogenic factors or metabolic wastes accumulated in the patient's body, but at the same time, complications or complications that may be accompanied by renal insufficiency may include anemia, pyelonephritis, urinary tract disease etc.
  • the medical device of the present application can be used for disease treatment by combining medicines and other treatment means such as surgery, dietary care, etc.
  • the medical device is used in combination with a drug for the treatment of a disease.
  • concentration of a specific molecule or a combination of molecules in a patient can be changed through the medical device of the present application, such as: reducing the concentration of a specific molecule or generating a specific molecule, and at the same time, when the patient performs disease treatment based on the medical device, the combination of drug therapy is used.
  • the drugs are drugs for disease complications, anticoagulants for plasma exchange technology, vasoactive drugs for the disease itself, anti-infective drugs and other drugs related to disease treatment, as long as the treatment equipment and drugs described in this application can be treated independently
  • the disease may be beneficial to health, or the combination of the two can achieve or be able to achieve a better therapeutic effect.
  • the present application also provides a computer-readable storage medium storing at least one program.
  • the at least one program is executed when called by the processor and implements the fluid processing method according to any one of the embodiments provided in the first aspect or the second aspect of the present application.
  • the functions, if implemented in the form of software functional units and sold or used as independent products, may be stored in a computer-readable storage medium.
  • the technical solution of the present application can be embodied in the form of a software product in essence, or the part that contributes to the prior art or the part of the technical solution, and the computer software product is stored in a storage medium, including Several instructions are used to cause a computer device (which may be a personal computer, a server, or a network device, etc.) to execute all or part of the steps of the methods described in the various embodiments of the present application.
  • the computer readable and writable storage medium may include read-only memory, random access memory, EEPROM, CD-ROM or other optical disk storage devices, magnetic disk storage devices or other magnetic storage devices, flash memory, A USB stick, a removable hard disk, or any other medium that can be used to store the desired program code in the form of instructions or data structures and that can be accessed by a computer. Also, any connection is properly termed a computer-readable medium.
  • the instructions are sent from a website, server, or other remote source using coaxial cable, fiber optic cable, twisted pair, digital subscriber line (DSL), or wireless technologies such as infrared, radio, and microwave
  • coaxial cable, fiber optic cable, twisted pair, DSL, or wireless technologies such as infrared, radio, and microwave
  • computer-readable storage media and data storage media do not include connections, carrier waves, signals, or other transitory media, but are instead intended to be non-transitory, tangible storage media.
  • Disk and disc includes compact disc (CD), laser disc, optical disc, digital versatile disc (DVD), floppy disk, and blu-ray disc, where disks usually reproduce data magnetically, while discs use lasers to optically reproduce data replicate the data.
  • the functions described in the computer program of the fluid processing method described in the first or second aspect of the present application may be implemented in hardware, software, firmware or any combination thereof.
  • the functions When implemented in software, the functions may be stored on or transmitted over as one or more instructions or code on a computer-readable medium.
  • the steps of the methods or algorithms disclosed herein may be embodied in processor-executable software modules, where the processor-executable software modules may reside on a tangible, non-transitory computer readable and writable storage medium.
  • Tangible, non-transitory computer-readable storage media can be any available media that can be accessed by a computer.
  • each block in the flowchart or block diagrams may represent a module, segment, or portion of code that contains one or more logical functions for implementing the specified functions executable instructions.
  • the functions noted in the blocks may occur out of the order noted in the figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality involved.
  • each block of the block diagrams and/or flowchart illustrations, and combinations of blocks in the block diagrams and/or flowchart illustrations can be implemented by dedicated hardware-based systems that perform the specified functions or operations , or can be implemented by a combination of dedicated hardware and computer instructions.

Abstract

La présente invention concerne un procédé de traitement de fluide, un dispositif de traitement de fluide, un dispositif de séparation de circulation, un système de traitement de circulation, un équipement médical, et un support de stockage lisible par ordinateur. Le procédé de traitement de fluide piège des matériaux cibles dans un fluide à l'aide d'une conduite d'enrichissement et d'un premier module de séparation et enrichit cycliquement les matériaux cibles dans la conduite d'enrichissement, et dans ce mode d'enrichissement cyclique, les débits du fluide au niveau d'un orifice d'entrée de fluide et d'un orifice de sortie de fluide dans la conduite d'enrichissement sont égaux afin d'équilibrer dynamiquement la quantité totale du fluide dans la conduite d'enrichissement. Ainsi, le procédé de traitement de fluide de la présente invention est durable en termes de traitement, et peut recueillir certains composants dans le fluide, qui sont les matériaux cibles. Le fluide évacué d'un premier orifice de drainage de la conduite d'enrichissement peut être relié à un module de traitement ou renvoyé au système d'origine. Ce procédé évite efficacement la perte continue des composants bénéfiques lorsque des composants nuisibles sont séparés durant la séparation de composant ou l'échange du fluide à travers la séparation membranaire.
PCT/CN2020/111881 2020-08-19 2020-08-27 Procédé de traitement de fluide et dispositif de traitement de fluide WO2022036738A1 (fr)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116492848A (zh) * 2023-06-27 2023-07-28 广州汉至蓝能源与环境技术有限公司 一种附带膜分离结构的发酵液成分提取装置及方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4191182A (en) * 1977-09-23 1980-03-04 Hemotherapy Inc. Method and apparatus for continuous plasmaphersis
US4397747A (en) * 1980-07-18 1983-08-09 Kawasumi Laboratories, Inc. Apparatus for plasma separation/exchange by double filtration
CN1845935A (zh) * 2003-09-05 2006-10-11 东丽株式会社 生物体成分组成改变了的溶液的调制方法
CN1934129A (zh) * 2004-01-21 2007-03-21 东丽株式会社 分级装置和分级方法
CN103263704A (zh) 2013-05-09 2013-08-28 浙江大学 配备储浆袋的血浆置换吸附滤过净化系统及其应用方法
US20160022895A1 (en) * 2013-01-15 2016-01-28 Takatori Corporation Stock solution concentrating device, stock solution treatment device, and circulation-type treatment device
CN105408467A (zh) * 2013-07-23 2016-03-16 株式会社钟化 细胞浓缩液的制造方法以及细胞悬浊液处理系统

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7291122B2 (en) * 2000-03-24 2007-11-06 Immunocept, L.L.C. Hemofiltration methods for treatment of diseases in a mammal
US8038638B2 (en) * 2004-02-23 2011-10-18 Hemolife Medical, Inc. Plasma detoxification and volume control system and methods of use
JP2011514182A (ja) * 2008-02-04 2011-05-06 ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク 流体分離装置、システム、及び方法
US9950103B2 (en) * 2016-03-03 2018-04-24 Micromedics Inc. Combination kidney and liver dialysis system and method

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4191182A (en) * 1977-09-23 1980-03-04 Hemotherapy Inc. Method and apparatus for continuous plasmaphersis
US4397747A (en) * 1980-07-18 1983-08-09 Kawasumi Laboratories, Inc. Apparatus for plasma separation/exchange by double filtration
CN1845935A (zh) * 2003-09-05 2006-10-11 东丽株式会社 生物体成分组成改变了的溶液的调制方法
CN1934129A (zh) * 2004-01-21 2007-03-21 东丽株式会社 分级装置和分级方法
US20160022895A1 (en) * 2013-01-15 2016-01-28 Takatori Corporation Stock solution concentrating device, stock solution treatment device, and circulation-type treatment device
CN103263704A (zh) 2013-05-09 2013-08-28 浙江大学 配备储浆袋的血浆置换吸附滤过净化系统及其应用方法
CN105408467A (zh) * 2013-07-23 2016-03-16 株式会社钟化 细胞浓缩液的制造方法以及细胞悬浊液处理系统

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116492848A (zh) * 2023-06-27 2023-07-28 广州汉至蓝能源与环境技术有限公司 一种附带膜分离结构的发酵液成分提取装置及方法
CN116492848B (zh) * 2023-06-27 2023-09-05 广州汉至蓝能源与环境技术有限公司 一种附带膜分离结构的发酵液成分提取装置及方法

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