WO2022030607A1 - Moyen d'élimination de micro-organismes pathogènes par micellisation - Google Patents

Moyen d'élimination de micro-organismes pathogènes par micellisation Download PDF

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Publication number
WO2022030607A1
WO2022030607A1 PCT/JP2021/029251 JP2021029251W WO2022030607A1 WO 2022030607 A1 WO2022030607 A1 WO 2022030607A1 JP 2021029251 W JP2021029251 W JP 2021029251W WO 2022030607 A1 WO2022030607 A1 WO 2022030607A1
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Prior art keywords
pathogenic microorganisms
surfactant
micelles
type
oral cavity
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PCT/JP2021/029251
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English (en)
Japanese (ja)
Inventor
裕 道脇
Original Assignee
Ｎｅｘｔ Ｉｎｎｏｖａｔｉｏｎ合同会社
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Priority to JP2022541745A priority Critical patent/JPWO2022030607A1/ja
Publication of WO2022030607A1 publication Critical patent/WO2022030607A1/fr

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058—Chewing gums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds

Definitions

  • the present invention relates to a micellar removing means for removing pathogenic microorganisms from the mucous membrane in the oral cavity.
  • pathogenic microorganisms invade through the mucous membranes of human eyes, nose, and mouth, they cause various diseases.
  • Hands skin are disinfected, sterilized, and washed with inverted soap or a bactericidal agent (see Patent Document 1).
  • the pathogenic microorganism can be removed from the finger, it is possible to prevent the pathogenic microorganism from adhering to the mucous membrane by contacting the finger with the eyes, nose and mouth.
  • pathogenic microorganisms may be contained in fine particles called microdroplets or aerosols that float in the air for a long time, and the fine particles may directly enter the body through the nose or mouth and adhere to the mucous membrane.
  • Patent No. 4450128 Japanese Unexamined Patent Publication No. 2016-174736 Japanese Unexamined Patent Publication No. 2015-67604
  • a virus invades the body by binding to a receptor, and has an infectious ability even in a small amount. Therefore, even if a non-woven fabric mask or the like is worn, it is not possible to prevent pathogenic microorganisms from invading the oral cavity, and there is a problem that sufficient infection prevention measures cannot be taken.
  • the present invention has been made by the intent of the present inventor in view of the above problems, and an object of the present invention is to provide a means for removing pathogenic microorganisms that have invaded the oral cavity and adhered to the mucous membrane by a simple structure. do.
  • the means for removing micelles of pathogenic microorganisms of the present invention is characterized by having a masticator and a surfactant contained in the masticator.
  • the means for removing micelles of pathogenic microorganisms of the present invention is characterized in that the surfactant contains a food-derived component.
  • the means for removing micelles of pathogenic microorganisms of the present invention is characterized in that the surfactant is encapsulated in microcapsules.
  • the means for removing micellarization of pathogenic microorganisms of the present invention is characterized in that a plurality of the microcapsules are present.
  • the means for removing micelles of pathogenic microorganisms of the present invention is characterized in that the masticator is any of a tablet confectionery type, a chew candy type, a gummy candy type, a hard candy type, a soft candy type, and a gum type.
  • the means for removing micelles of pathogenic microorganisms of the present invention is characterized in that the masticator disperses and arranges bubbles inside, and a surfactant is present in the bubbles.
  • the means for removing micellarization of pathogenic microorganisms of the present invention is characterized by having a second microcapsule encapsulated in the chew and containing a diluent.
  • the means for removing micelles of pathogenic microorganisms of the present invention is characterized in that the diluent contains one or more of water, a fragrance, an acidulant, a bitterness agent, a sweetening agent, and a preservative.
  • the means for removing micelles of pathogenic microorganisms of the present invention is characterized in that the surfactant is an aromatic compound having a cyclic structure of a six-membered ring and having a plurality of hydroxyl groups.
  • pathogenic microorganisms that have invaded the oral cavity and adhered to the mucous membrane can be removed.
  • micellar removing means of the present invention will be described.
  • the present invention is not limited to the following examples and the like, and can be arbitrarily modified and carried out without departing from the gist of the present invention.
  • FIG. 1 is a schematic view showing a chewable structure 1 as a means for removing micelles according to the present embodiment.
  • the masticatory structure 1 is a microcapsule 4 in which a surfactant 2 is encapsulated, which is embedded in the masticatory body 10.
  • the masticatory structure 1 has an open cell type, that is, a structure in which bubbles are dispersed in the masticatory body 10.
  • Surfactant 2 includes food-derived substances such as saponin, lecithin, peptide, and sodium caseinate, and synthetic additives such as glycerin fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, sucrose fatty acid ester, and oxyethylene fatty acid alcohol.
  • synthetic additives such as glycerin fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, sucrose fatty acid ester, and oxyethylene fatty acid alcohol.
  • so-called emulsifiers such as sodium oleate and morpholine fatty acid salt, polyoxyethylene higher fatty acid alcohol, stearoyl calcium lactate, and ammonium monoglyceride phosphate, it is preferable to contain at least one kind, and a foaming property is selected.
  • the substance is capable of exfoliating from the mucous membrane while micellarizing pathogenic microorganisms such as viruses and bacteria adhering to the mucous membrane of the upper airway such as the oral cavity and the pharynx by ingesting it into the oral cavity.
  • the surfactant 2 is a linear alkylbenzene sulfonate sodium, an alkyl glycoside, an alkylamine oxide, a benzalkonium chloride, a benzethonium chloride, a dialkyldimethylammonium chloride, a polyoxyethylene alkyl ether, and a pure soap that inactivates bactericidal and pathogenic microorganisms.
  • Min potassium fatty acid
  • pure soap sodium fatty acid
  • the like may be diluted to an appropriate concentration.
  • the microcapsules 4 are formed by coating a surface active agent 2 which is a core substance with a film film, and the film film can be used as a base for hard capsules such as gelatin and hydroxypropylmethyl cellulose, gelatin and the like.
  • a soft capsule base containing glycerin or sorbitol can be used.
  • excipients such as starch, lactose, dextrin, sucrose, and precipitated silica may be used.
  • agar, pectin, sheep intestine, oblate and the like can also be adopted.
  • the microcapsules 4 are embedded in the chewing body 10 and are formed to have a particle size of about 0.1 mm to 3 mm.
  • the method for producing the microcapsules 4 is not particularly limited, but for example, the surfactant 2 may be wrapped in a sheet of gelatin, and the surfactant 2 is placed in a substantially cylindrical hard capsule having one end closed. It may be packed and closed with a cap. Further, a method of dropping into the coagulating liquid using a double or triple nozzle called a dropping method can also be adopted.
  • the masticator 10 is preferably one that can be chewed at least repeatedly and the surfactant 2 can foam in the oral cavity, and is preferably a tablet confectionery type, a chewing candy type, a gummy candy type, a hard candy type, or a soft candy type. , May be gum type.
  • the chewing body 10 may have a structure in which the hardness differs between the outer side and the inner side, and for example, the chewing body 10 may be configured such that the outer side is a hard candy type and the inner side is a gum type.
  • the microcapsules 4 are crushed and the surfactant 2 is released from the inside.
  • the surfactant 2 and saliva are mixed and foamed in the oral cavity, and the foam fills the oral cavity.
  • the bubbles that have expanded to the upper respiratory tract wrap around the virus (pathogenic microorganism) adhering to the mucous membrane and peel it off from the mucous membrane while generating micelles.
  • the lipophilic group of the surfactant 2 binds to the hydrophobic component, which is the surface characteristic of the virus, to generate micelles that enclose each virus on a nanoscale, and from the upper respiratory tract mucosa.
  • the hydrophilic group of the surfactant 2 binds to water such as saliva in the oral cavity to remove the virus.
  • a foaming action is generated in the oral cavity, and the virus that has adhered to the oral cavity, the upper respiratory tract, etc. can be wrapped by the foam and peeled off from the mucous membrane. That is, since the virus that has invaded the oral cavity and adhered to the mucous membrane can be inactivated while being removed, the risk of infection can be reduced.
  • saliva and a surfactant are mixed to generate a foaming action in the oral cavity, but unlike the microcapsules 4, a second microcapsule containing a diluent such as water is enclosed.
  • a diluent, saliva, and a surfactant may be mixed to generate a foaming action, so that a micellar formation precursor state can be created.
  • the foaming action can be easily generated in the oral cavity or a micellar formation precursor state can be created in the oral cavity. be able to.
  • the high-concentration surfactant 2 may be encapsulated in the microcapsules 4, and the surfactant 2 may be mixed with a diluent to an appropriate concentration while chewing the chewing body 10.
  • the diluent may be one containing one or more of a fragrance, an acidulant, a bitterness agent, a sweetening agent, a preservative and the like, for example, one mixed with water.
  • the diluent may contain a refreshing component such as mint or xylitol.
  • air bubbles are arranged inside the chewing body 10, but of course, the chewing body 10 does not necessarily have to contain air bubbles. However, if the chewing body 10 contains air bubbles inside, the surfactant 2 foams in the air bubbles during repeated chewing after the microcapsules are crushed, causing foaming in the oral cavity.
  • the surface active agent 2 can be easily dispersed in the oral cavity, the upper respiratory tract, and the like, and the virus can be removed in a wide range.
  • microcapsules 4 containing the surfactant-like compound may be embedded in the masticatory body to form the masticatory structure 1. That is, among the compounds contained in food / plant tissues, those having an amphipathic molecular structure may be used as a surfactant.
  • Examples of compounds having an amphoteric molecule can be compounds, compound families, and compound classes, including catechols, catechins, flavanoids, flavanols, flavonoids, quercetin, hesperidin, tannins, and the like. Further, ubiquinol, coenzymes Q-12 and Q-10, uric acid, methionine, glutathione, thymol, carvacrol, eugenol, and water-soluble and fat-soluble vitamins may be used.
  • the aromatic compound having a plurality of aromatic compounds has a structure corresponding to a surfactant capable of inactivating pathogenic microorganisms.
  • Surfactant-like compounds strongly bind to proteins and also bind to water such as saliva by their hydrophilic groups to form micelles.
  • especially pathogenic microorganisms such as enveloped viruses have lipophilicity on the surface and are composed of spikes that bind to protein receptors such as ACE2, which are locally distributed in many human mucosa. It can be said that it is a mass of protein.
  • the above compound forms micelles having a pathogenic microorganism as a core while binding to a pathogenic microorganism using a lipophilic group and binding to saliva using a hydrophilic group.
  • the action of this compound inactivates pathogenic microorganisms (particularly enveloped viruses) and prevents pathogenic microorganisms from binding to ACE2 proteins and the like. That is, like the surfactant, by putting the compound in the oral cavity, it adheres to the oral mucosa and inactivates the pathogenic microorganism. This has the effect of preventing the invasion of pathogenic microorganisms into the body.
  • the masticatory structure 1 has been described as being composed of a masticatory body containing microcapsules, the masticatory structure may be formed by at least an edible powder or granular material impregnated with a surfactant.
  • the flours are, for example, wheat flour, rice flour, barley flour, rye flour, corn flour, tef flour, hie flour, kina flour, soybean flour, chick flour, pea flour, soybean flour, kataguri flour, kudzu flour, tapioca flour, potato flour. , Chestnut flour, acorn flour, coconut flour and other flours, sugar and salt.
  • the chewable structure of the present invention may be in the form of tablets or confectionery, which is formed by compression-molding a powdery surfactant.
  • the method for powdering the surfactant is not particularly limited, but for example, it can be dried by using a vacuum freeze-drying technique to be powdered.
  • the chewable structure to be compression-molded includes surfactants and surfactant-like compounds that inactivate pathogenic microorganisms, as well as, for example, excipients, stabilizers, preservatives, disintegrants, flavoring agents, lubricants, etc. It is composed of an isotonic agent and the like.
  • the excipient is lactose, crystalline cellulose, starch or the like, and is used to improve the handling or molding of the chewable structure and to make it convenient to take.
  • the binder is sodium carmellose or the like, and is used when solidifying a powdered surfactant or the like.
  • the stabilizer is sodium bisulfite or the like, and is used to prevent the active ingredient from decomposing.
  • the preservative is paraoxybenzoic acid ester (paraben), benzalkonium chloride, chlorobutanol, cresol and the like, and is used to suppress the growth of microorganisms in the chewable structure and prevent deterioration and putrefaction.
  • the disintegrant is carmellose calcium, crystalline cellulose or the like, and is used to disintegrate the masticatory structure in the oral cavity.
  • the flavoring agent is citric acid or the like, and is used to adjust the taste.
  • Lubricants are magnesium stearate, talc, hydrogenated vegetable oil, etc., which improve the fluidity of powders and granules, improve slippage during compression molding, prevent tableting problems such as sticking, and gloss on the tablet surface. Used to give.
  • the tonicity agent is sodium chloride, glucose, etc., and is used to adjust the osmotic pressure with the body fluid.

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  • Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Oral & Maxillofacial Surgery (AREA)
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Abstract

La présente invention présente un objet à mâcher et un tensioactif encapsulé dans l'objet à mâcher.
PCT/JP2021/029251 2020-08-06 2021-08-06 Moyen d'élimination de micro-organismes pathogènes par micellisation WO2022030607A1 (fr)

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JP2020134247 2020-08-06
JP2020-134247 2020-08-06
JP2020187697 2020-11-11
JP2020-187697 2020-11-11

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Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS565052A (en) * 1979-06-18 1981-01-20 Life Savers Inc Nonncalorie chewing gum base
JPS5615652A (en) * 1979-07-18 1981-02-14 Lotte Co Ltd Production of porous candy gum
JPS63209548A (ja) * 1987-02-26 1988-08-31 アルフア　ガム　インベストメント　インコ−ポレ−テツド チユ−イングガム
JPH0938183A (ja) * 1995-07-31 1997-02-10 Takasago Internatl Corp 消臭剤組成物
JP2006506422A (ja) * 2002-11-12 2006-02-23 キャドバリー・アダムズ・ユーエスエイ・エルエルシー カプセル封入された汚れ除去剤を含むチューイングガムおよび糖菓組成物、その製造方法および使用
US20070134168A1 (en) * 2005-12-02 2007-06-14 Dodds Michael W Chewable compositions with fast release magnolia bark extract
US20110045073A1 (en) * 2008-02-19 2011-02-24 Innopact B.V. Methods and compositions of sphingolipid for preventing and treating microbial infections
JP2011160734A (ja) * 2010-02-10 2011-08-25 Lotte Co Ltd 舌苔除去作用効果を有する食品

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS565052A (en) * 1979-06-18 1981-01-20 Life Savers Inc Nonncalorie chewing gum base
JPS5615652A (en) * 1979-07-18 1981-02-14 Lotte Co Ltd Production of porous candy gum
JPS63209548A (ja) * 1987-02-26 1988-08-31 アルフア　ガム　インベストメント　インコ−ポレ−テツド チユ−イングガム
JPH0938183A (ja) * 1995-07-31 1997-02-10 Takasago Internatl Corp 消臭剤組成物
JP2006506422A (ja) * 2002-11-12 2006-02-23 キャドバリー・アダムズ・ユーエスエイ・エルエルシー カプセル封入された汚れ除去剤を含むチューイングガムおよび糖菓組成物、その製造方法および使用
US20070134168A1 (en) * 2005-12-02 2007-06-14 Dodds Michael W Chewable compositions with fast release magnolia bark extract
US20110045073A1 (en) * 2008-02-19 2011-02-24 Innopact B.V. Methods and compositions of sphingolipid for preventing and treating microbial infections
JP2011160734A (ja) * 2010-02-10 2011-08-25 Lotte Co Ltd 舌苔除去作用効果を有する食品

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