WO2022027747A1

WO2022027747A1 - Liquid medicine filling method

Info

Publication number: WO2022027747A1
Application number: PCT/CN2020/111390
Authority: WO
Inventors: 龙煌辉; 柏天桥; 易波; 黄少友; 李�杰; 于宁
Original assignee: 楚天科技股份有限公司
Priority date: 2020-08-05
Filing date: 2020-08-26
Publication date: 2022-02-10
Also published as: CN111846307B; CN111846307A

Abstract

Disclosed is a liquid medicine filling method. A front weighing station (1), a filling station (2), a rear weighing station (3), a liquid distribution container (4) and a filling needle frame are involved. The bottom of the liquid distribution container (4) is obliquely arranged, and is provided with a plurality of liquid outlets (41) in the lengthwise direction thereof; filling needles (5) arranged side by side are disposed on the filling needle frame; each of the liquid outlets (41) is connected to each of the filling needles (5) by means of a flexible pipe (6); and each flexible pipe (6) is provided with a filling pump (61). The filling method comprises: the front weighing station (1) carrying out front weighing on empty bottles; the filling needle frame moving, such that some of the filling needles (5) are located above the rear weighing station (3), and the remaining filling needles (5) are located above the filling station (2); and the filling needles (5) above the filling station (2) performing quantitative filling on medicine bottles, and then the filling needles (5) above the rear weighing station (3) weighing the medicine bottles and also supplementing liquid in same, such that the medicine amount in each medicine bottle reaches the standard. The liquid medicine filling method can reduce the amount of liquid medicine wasted, reduce the manufacturing cost and improve the production efficiency.

Description

A kind of liquid medicine filling method

technical field

The invention relates to the technical field of food and medicine packaging machinery and equipment, in particular to a liquid medicine filling method.

Background technique

The existing liquid medicine filling device includes a filling needle, a filling station, a pre-weighing station located in front of the filling station for weighing empty bottles, and a pre-weighing station located after the filling station for weighing the filled liquid. In the post-weighing station of the total bottle, the filling needle is fixed above the filling station, so that a liquid replenishing mechanism must be set up on the subsequent station of the filling station to replenish the bottle body that has not been filled with liquid up to the standard. , the manufacturing cost of the liquid medicine filling device is increased, and the production efficiency is low. Moreover, the existing fluid replenishment mechanism has low fluid replenishment efficiency, and it is difficult to fill the high-efficiency fluid replenishment requirements. In addition, when the existing medicinal liquid filling device is used to fill the medicinal liquid, a large amount of medicinal liquid is wasted. At the same time, the filling volume of liquid medicine needs to be strictly controlled. Especially in the initial stage of medicine filling, there is air in the pipeline of the filling device. It is difficult to accurately and quantitatively fill the filling. If it does not meet the filling standard, it must be rejected, resulting in waste of medicines. Moreover, at the end of a batch of medicinal liquid filling process, due to the insufficient total medicinal liquid volume, when filling multiple medicinal liquids with medicinal liquids, it is difficult to ensure that the filling volume in the medicinal liquids is qualified, and the medicinal liquid Bottles with substandard fillings must also be rejected, again resulting in waste of medicines.

In the emptying and tail liquid filling stages of the production preparation stage of the filling system, manual intervention is generally used for processing, which has low efficiency, high risk of pollution, and large residues of liquid medicine. According to different filling specifications and the number of filling heads, the general residual amount ranges from 500ml to 2000ml. If the residual liquid medicine is used well, according to the 2ml bottle size, one batch can produce more than 500-1000 bottles of qualified products. According to the market value of 100 yuan per bottle, one batch can produce more than 100 bottles. Products with a market value of 50,000-100,000 can be calculated in 100 batches a year, and more products with a market value of 5-10 million can be produced. For high value-added biological drugs and innovative drugs, the economic benefits generated are huge.

technical problem

The technical problem to be solved by the present invention is to overcome the deficiencies of the prior art, and to provide a liquid medicine filling method that can reduce manufacturing costs, improve production efficiency and reduce waste of liquid medicine.

technical solutions

In order to solve the above-mentioned technical problems, the present invention adopts the following technical solutions:

A medicinal liquid filling method is carried out by using a medicinal liquid filling device, the medicinal liquid filling device comprises a front weighing station, a filling station, a rear weighing station, a liquid separation container and a movable needle filling rack, The bottom of the liquid dispensing container is inclined and provided with a plurality of liquid outlets along the length direction, and a plurality of irrigation needles arranged side by side are arranged on the injection needle rack, and each of the liquid outlets and each injection needle respectively pass through a hose connection, each of the hoses is provided with a filling pump, and the filling method includes:

The pre-weighing station pre-weighs the empty bottles;

The filling needle rack moves so that some filling needles are located above the rear weighing station, and the rest of the filling needles are located above the filling station;

The irrigation needle above the filling station is quantitatively filled with medicine bottles, and the irrigation needle above the post-weighing station is used to refill the medicine bottle while weighing, so that the amount of medicine in each medicine bottle reaches the standard.

As a further improvement of the above technical solution:

The filling method further includes: moving the filling needle rack so that each filling needle is located above the filling station for quantitative filling.

The filling needle above the post-weighing station is connected to the lower liquid outlet on the liquid dispensing container, and the filling needle above the filling station is connected to the upper liquid outlet of the liquid separation container.

The part of the irrigation needle is a single irrigation needle.

The filling needle above the post-weighing station is connected to the liquid outlet at the lowest position on the liquid dispensing container.

The liquid medicine filling device also includes a medicine supply device, a liquid inlet valve and a buffer tank. The medicine supply device and the buffer tank are connected by a liquid inlet pipeline, and a liquid inlet valve is arranged on the liquid inlet pipeline. The tank and the liquid separation container are connected by connecting pipes.

The top of the liquid separation container is provided with a liquid inlet, and the buffer tank is connected with the liquid inlet of the liquid separation container through a connecting pipeline.

The inclination angle of the liquid separation container is a, 0°<a≤10°.

beneficial effect

Compared with the prior art, the advantages of the present invention are:

The liquid medicine filling method of the present invention is carried out by using a liquid medicine filling device. The liquid medicine filling device includes a pre-weighing station, a filling station, a post-weighing station, a liquid separation container and a movable needle filling rack. The bottom of the liquid container is inclined and is provided with a plurality of liquid outlets along the length direction, and a plurality of irrigation needles arranged side by side are arranged on the filling needle rack. A filling pump is provided, and the filling method includes: pre-weighing the empty bottles at the front weighing station; moving the filling needle rack so that some filling needles are located above the rear weighing station, and the rest of the filling needles are located above the filling station; The bottle above the filling station is quantitatively filled with the bottle, and the bottle above the weighing station is filled with liquid while weighing, so that the amount of medicine in each bottle reaches the standard. The irrigation needle above the filling station is quantitatively filled with medicine bottles, and the irrigation needle above the post-weighing station is used to refill the medicine bottle while weighing, so that the amount of medicine in each medicine bottle reaches the standard. Since the filling needles are installed on the filling needle rack, each filling needle can adjust the position with the filling needle rack. In this liquid medicine filling method, some filling needles on the filling needle frame are located above the rear weighing station to replace the original one. The refilling mechanism performs refilling, thereby reducing the manufacturing cost. Through the irrigation above the post-weighing station, the medicine bottle is filled with liquid while weighing, which improves the production efficiency and reduces the waste of liquid medicine.

Description of drawings

FIG. 1 is a schematic structural diagram of the liquid medicine filling device of the present invention in the preparation stage.

2 is a schematic structural diagram of the liquid medicine filling device of the present invention during normal filling and production.

3 is a schematic structural diagram of the liquid medicine filling device of the present invention when the tail liquid is filled.

FIG. 4 is a schematic structural diagram of the liquid dispensing container of the liquid medicine filling device of the present invention.

The symbols in the figure represent:

1. Front weighing station; 2. Filling station; 3. Rear weighing station; 4. Dispensing container; 41. Liquid outlet; 42. Liquid inlet; 5. Filling needle; 6. Hose; 61 , filling pump; 7, drug supply device; 8, liquid inlet valve; 9, buffer tank.

Embodiments of the present invention

The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

Figures 1 to 4 show an embodiment of the liquid medicine filling method of the present invention. The liquid medicine filling method adopts a liquid medicine filling device. The liquid medicine filling device includes a pre-weighing station 1, a filling station Position 2, post-weighing station 3, liquid dispensing container 4 and movable needle filling rack, the bottom of liquid dispensing container 4 is inclined and is provided with a plurality of liquid outlets 41 along the length direction, and the needle filling rack is provided with a plurality of side-by-side For the arranged filling needles 5, each liquid outlet 41 is connected with each filling needle 5 through a hose 6, and each hose 6 is provided with a filling pump 61. The filling method includes:

Pre-weighing station 1 pre-weighs the empty bottles;

The needle filling rack moves, so that some filling needles 5 are located above the rear weighing station 3, and the rest of the filling needles 5 are located above the filling station 2;

The filling needle 5 above the filling station 2 fills the medicine bottle quantitatively, and the filling needle 5 above the post-weighing station 3 weighs and replenishes the medicine bottle, so that the amount of medicine in each medicine bottle reaches the standard. Since the filling needles are installed on the filling needle rack, the positions of each filling needle can be adjusted with the filling needle rack. In this liquid medicine filling method, some of the filling needles 5 on the filling needle frame are located above the rear weighing station 3 to replace the The original refilling mechanism performs refilling, thereby reducing the manufacturing cost. The medicine bottle is filled with liquid while weighing through the filling needle 5 above the rear weighing station 3, which improves the production efficiency and reduces the waste of liquid medicine.

In this embodiment, the filling method further includes: moving the filling needle rack so that each filling needle 5 is positioned above the filling station 2 to perform quantitative filling. Specifically, the filling needle rack moves so that each filling needle 5 is located above the filling station 2, and normal filling production is performed.

In this embodiment, the filling needle 5 above the post-weighing station 3 is connected to the lower liquid outlet 41 of the liquid dispensing container 4 , and the filling needle 5 above the filling station 2 is connected to the upper liquid outlet 41 of the liquid dispensing container 4 41 connections. For example, the number of filling needles 5 is 8, and each filling needle 5 is numbered 1-8 filling needles 5 from front to back along the bottle feeding direction F of the medicine bottle, and each liquid outlet 41 is numbered 1-8 from low to high. No. 8 liquid outlet 41, No. 1-8 filling needle 5 and No. 1-8 liquid outlet 41 are connected in one-to-one correspondence according to the serial number. The filling needle 5 (referred to as the low filling needle 5 ) at the lower liquid outlet 41 on the liquid dispensing container 4 is used for liquid replenishment, thereby reducing the residual amount of medicinal liquid in the liquid dispensing container 4 and reducing the waste of medicinal liquid.

In this embodiment, some of the irrigation needles 5 are one irrigation needle 5 . That is to say, the filling needle holder only needs to move forward one position, so that a filling needle 5 (No. 1 filling needle 5) can be located on the rear weighing station 3, and back to a position, it can make No. 1 filling needle 5 times. to the filling station 2, thereby reducing the movement of the needle filling rack to improve work efficiency. The filling needle 5 (No. 1 filling needle 5) above the post-weighing station 3 is connected to the lowest liquid outlet 41 (No. 1 liquid outlet 41) on the liquid separation container 4, and the liquid is replenished through the lowest liquid outlet 41 , so that the liquid medicine in the liquid dispensing container 4 can be completely filled, which further reduces the wasted amount of the liquid medicine.

Specific steps are as follows:

S1: As shown in Figure 1, in the preparation stage, each filling needle 5 is placed above the filling station 2; after the pre-weighing station 1 pre-weighs the medicine bottle, the medicine bottle is transported to the filling station 2 Align each medicine bottle on the filling station 2 with each filling needle 5, turn on each filling pump 61, and perform quantitative filling and emptying; move each filling needle 5 forward by one position, so that the moving frame The frontmost filling needle 5 (A1 size filling needle 5) is located on the rear weighing station 3; move the medicine bottle on the filling station 2 forward one position at a time, so that the frontmost medicine bottle is moved to the rear weighing station. Position 3; carry out quantitative filling of a single bottle, and add liquid while weighing, until the amount of medicine in the bottle reaches the standard; (the filling needle rack moves one position, one bottle at a time, using quantitative filling + supplementary filling)

S2: As shown in Figure 2, for normal quantitative filling production, move each filling needle 5 backward by one position, so that each filling needle 5 is returned to the top of the filling station 2, and perform normal quantitative filling production. Packing multiple bottles; (return the needle holder, 8 bottles at a time, quantitative filling)

S3: As shown in Figure 3, the tail fluid is filled, and each filling needle 5 is moved forward by one position, so that the frontmost filling needle 5 on the moving frame is aligned with the rearmost weighing device 31 on the rear weighing station 3 On the top, as the refilling needle 5 , other filling needles 5 quantitatively fill the medicine bottle below, and the medicine bottle that does not meet the standard is refilled through the rehydration filling needle 5 until the liquid in the liquid separation container 4 is emptied. (The filling needle holder is moved to one position, 1 bottle at a time, 80% quantitative filling + rehydration)

In the pre-filling preparation stage, the air in the pipeline is drained. At this time, due to the influence of the air in the pipeline, the filling volume of the medicine bottle does not meet the standard. cause waste of medicines. When the amount of medicine in the dispensing container 4 is insufficient, the high-level filling needle 5 will be filled quantitatively first, and the low-level filling needle 5 will be filled one by one, so as to effectively utilize the tail liquid (remaining liquid medicine) and ensure that at most one bottle of liquid medicine is filled. Failed.

In this embodiment, the liquid medicine filling device further includes a medicine supply device 7, a liquid inlet valve 8 and a buffer tank 9. The medicine supply device 7 and the buffer tank 9 are connected by a liquid inlet pipeline, and a liquid inlet valve is provided on the liquid inlet pipeline. 8. The buffer tank 9 is connected with the liquid separation container 4 through the connecting pipeline. The top of the liquid separation container 4 is provided with a liquid inlet 42, and the buffer tank 9 is connected with the liquid inlet 42 of the liquid separation container 4 through a connecting pipeline. The inclination angle of the liquid separation container 4 is a, 0°<a≤10°.

The filling method of the liquid medicine filling device is as follows:

The first step, filling and emptying (for example, the number of filling needles 5 is 8, and the number of scales in the rear weighing station 3 is 8, for example, the filling needles 5 are labeled from front to back as A1-A8 filling needles 5, and the scales are The scales are labeled B1-B8 from front to back, and 8 medicine bottles are in a group, and the bottles are labeled C1-C8 from front to back)

a) The buffer tank 9 is intermittently supplied with liquid to realize bubble-free filling in the liquid separation container 4;

b) Move the filling rack to move the A2-A8 filling needles 5 to the front weighing station 1, and the A1 filling needle 5 to the rear weighing station 3;

c) The number of bottles in a single pass is 1, and the bottles are continuously fed;

d) When the C2-C8 medicine bottle is aligned with the A2-A8 filling needle 5 respectively, and the C1 medicine bottle is aligned with the A1 filling needle 5, the bottle feeding is suspended;

e) According to the parameters of the pipe length and pipe diameter from the liquid dispensing container 4 to each filling needle 5, the filling pump 61 is used to continuously pump medicine to empty and fill the corresponding pipeline, and the number of emptying is controlled to ensure that the filling volume is within the target filling volume. If the filling amount is insufficient, the follow-up filling is made up through the A1 filling needle 5 while filling;

f) After obtaining the tare weight of the C2-C8 medicine bottle, fill it once, and continue to pass the bottle individually;

g) The deviation values of the C2-C8 bottles are obtained one by one at the post-weighing station 3, and the liquids are replenished one by one;

h) After completing a group of medicine bottles, continue to tare the next C2-C8 medicine bottles, fill them, and move the bottles individually;

i) Cache the net weight value of each medicine bottle for a single filling, which is used to judge whether to perform filling calibration;

j) Judging whether the filling amount of each bottle is qualified, if qualified, continue to the next group of bottle filling; if not qualified, then jump to step f, and the target filling amount at this time is the deviation value obtained in the previous round of the bottle;

k) Continuously judge the net weight value of 2 groups of single filling, and measure the comparative deviation value, if it is within a certain range (for example: within 1% of the internal deviation), calculate the average value for calibration;

m) Continue filling until 5 single fillings per filling needle are qualified.

The second step, enter the normal filling

The third step, tail liquid filling

a) When the low liquid level of the medicinal liquid in the buffer tank 9 is detected by the load cell of the buffer tank 9, the tail liquid filling mode is entered;

b) By detecting the weight of the remaining medicinal liquid in the buffer tank 9 and the volume of the input liquid dispensing container 4 and the hose 6, combined with the current filling amount, through calculation, a certain number of groups of normal filling can be maintained, and the entire remaining medicinal liquid can be roughly filled. 50% (can be set according to the loading);

g) Obtain the deviation values of the C2-C8 bottles one by one on the B8 scale on the rear weighing station 3, and replenish the liquid one by one;

h) After completing a group of bottles, continue to tare the next C2-C8 bottles, fill them, and move the bottles individually;

i) If the filling volume of a filling pump 61 connected to the filling needle 5 of A2-A8 is lower than 20%, the filling corresponding to the filling pump 61 is stopped, and the waste is directly rejected;

j) Finally, only the C2 bottle is fed, and when the corresponding filling pump 61 runs for more than 30s and the filling volume does not reach the target filling volume, the whole process ends and the production stops.

Although the present invention has been disclosed above with preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art, without departing from the scope of the technical solution of the present invention, can make many possible changes and modifications to the technical solution of the present invention by using the technical content disclosed above, or modify it into an equivalent implementation of equivalent changes. example. Therefore, any simple modifications, equivalent changes and modifications made to the above embodiments according to the technical essence of the present invention should fall within the protection scope of the technical solutions of the present invention without departing from the content of the technical solutions of the present invention.

Claims

A medicinal liquid filling method, characterized in that: the medicinal liquid filling device is used, and the medicinal liquid filling device comprises a pre-weighing station (1), a filling station (2), and a post-weighing station (3). ), a liquid dispensing container (4) and a movable needle filling rack, the bottom of the liquid dispensing container (4) is inclined and provided with a plurality of liquid outlets (41) along the length direction, and the needle filling rack is provided with A plurality of filling needles (5) arranged side by side, each of the liquid outlets (41) is connected with each filling needle (5) through a hose (6), and each of the hoses (6) is provided with filling The pump (61), the filling method comprises:

Pre-weighing station (1) Pre-weighing the empty bottles;

The filling needle rack moves so that some filling needles (5) are located above the rear weighing station (3), and the remaining filling needles (5) are located above the filling station (2);

The filling needle (5) above the filling station (2) fills the medicine bottle quantitatively, and the filling needle (5) above the post-weighing station (3) weighs and replenishes the medicine bottle, so that each medicine bottle is filled with liquid. The dosage of the drug is up to standard.
The liquid medicine filling method according to claim 1, characterized in that: the filling method further comprises: moving the filling needle rack, so that each filling needle (5) is located above the filling station (2), and quantitative filling is performed. Pack.
The liquid medicine filling method according to claim 1, characterized in that: the filling needle (5) above the post-weighing station (3) is connected to the liquid outlet (41) at the upper and lower positions of the liquid dispensing container (4). , the filling needle (5) above the filling station (2) is connected with the high liquid outlet (41) on the liquid separation container (4).
The liquid medicine filling method according to claim 1, characterized in that: the part of the filling needle (5) is a filling needle (5).
The liquid medicine filling method according to claim 4, characterized in that: the filling needle (5) above the post-weighing station (3) and the liquid outlet (41) at the lowest position on the liquid dispensing container (4) connect.
The liquid medicine filling method according to any one of claims 1 to 5, wherein the liquid medicine filling device further comprises a medicine supply device (7), a liquid inlet valve (8) and a buffer tank (9). ), the medicine supply device (7) and the buffer tank (9) are connected through a liquid inlet pipeline, and the liquid inlet pipeline is provided with a liquid inlet valve (8), and the buffer tank (9) is connected to the liquid separation container ( 4) Connect by connecting pipeline.
The liquid medicine filling method according to claim 6, characterized in that: a liquid inlet (42) is provided on the top of the liquid separation container (4), and the buffer tank (9) and the liquid separation container (4) are provided with a liquid inlet (42). The liquid inlet (42) is connected by connecting pipeline.
The liquid medicine filling method according to any one of claims 1 to 5, characterized in that: the inclination angle of the liquid separation container (4) is a, where 0°<a≤10°.